OOIR: Observatory of International Research

Papers

(The TQCC of Toxicologic Pathology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Toxicologic Pathology Forum Opinion: Interpretation of Gliosis in the Brain and Spinal Cord Observed During Nonclinical Safety Studies	52
Early-Onset Asymptomatic Polypoid Cystitis in Two Adolescent Male Beagle Dogs	27
Guide for Combining Primary Tumors for Statistical Analysis in Rodent Carcinogenicity Studies	24
Toxicologic Pathology Forum: Opinion on Interpretive Challenges for Procedure-Related Effects Associated With Direct Central Nervous System Delivery of Oligonucleotides to Rodents, Dogs, and Nonhuman	22
A Pathologist’s Guide to Non-clinical Safety Assessment of Adoptive Cell Therapy Products	17
Comparative Study of Chemically Induced Renal Mesenchymal and Mammary Tumors in Female Sprague-Dawley and Wistar Rats	15
Thymic Epithelial Hyperplasia and Thymoma in Control rasH2 Transgenic Mice From 26-Week Carcinogenicity Assays	14
Time-Dependent Autolysis in Ex Vivo–Maintained Rat Tissue in Saline: A Descriptive Study and Practical Guidance for Histopathologic Assessment	13
Toxicologic Pathology Forum*: Opinion on Assessing and Communicating Adversity for Implantable Medical Devices	12
Retraction Notice: “Role of Quercetin in Preventing Thioacetamide-Induced Liver Injury in Rats”	12
Scientific and Regulatory Policy Committee Points to Consider: Proposal and Recommendations to Reduce Euthanasia of Control Nonhuman Primates in Nonclinical Toxicity Studies	12
Spontaneous Abdominal Hemangiosarcoma With Metastases to the Lungs in a Control Sprague-Dawley Rat	11
Toxicologic Pathology Forum: mRNA Vaccine Safety–Separating Fact From Fiction	11
Neuro Omics: Translational Neuropathology Applications of Spatial Technologies From Nonclinical Models to Human Disease	10
Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats	10
Toxicologic Pathology Forum*: Opinion on the Interpretation of Statistical Significance Testing Results From Anatomic and Clinical Pathology Data in Nonclinical Safety Studies	9
Hemangiosarcomas in Intercostal Brown Adipose Tissues of the Sternum Induced by Urethane in TgrasH2 Mice	9
Interpretative Challenges in Animal Studies: Review of Case Studies and Implications for Toxicologic Pathology	9
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity	9
Difference in the Mechanism of Iron Overload–Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats	9
Placental Lesions in CD-1 Mouse Placenta Following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)	8
Navigating the Pathology Minefield: Harnessing the Value of Historical Control Data in Rodent Carcinogenicity Studies	8
Oligonucleotides: Evolution of Carcinogenicity and Risk Assessment Strategy	8
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studi	8
Comparative Impact of Various Fasting Periods on the Welfare of Sprague-Dawley Rats With or Without Supplementation	8

Injection-Site Sarcomas in Rodent Carcinogenicity Studies: Human Relevance and Labeling Implications	8
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice	8
Neurofilament Light Chain: A Translational Safety Biomarker for Drug-Induced Peripheral Neurotoxicity	7
Virtual Control Groups in Non-clinical Toxicity Studies: Impacts on Toxicologic Clinical Pathology Data Interpretation	7
Cardiac Rhabdomyoma in Four Göttingen Minipigs	7
Scientific and Regulatory Policy Committee Points to Consider*: Sample Selection, Assay Design, Data Generation and Interpretation, and Reporting Practices for Chromogenic Immunohistochemical (IHC) As	7
Toxicologic Pathology Forum: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry	7
Adeno-Associated Virus Gene Therapy: Is There a Risk of Insertional Mutagenesis?	7
Transmission Electron Microscopy of the Peripheral Nervous System: Methods, Sample Preparation, and Case Studies	6
Pathophysiology of Ischemic Cell Death in the Central Nervous System	6
New Approach Methodologies (NAMs) for Carcinogenicity Evaluation	6
Proceedings of the 2024 Classic Examples in Toxicologic Pathology XXXI	6
Applications of Cell-Based Protein Array Technology to Preclinical Safety Assessment of Biological Products	6
Morphologic Features and Deep Learning–Based Analysis of Canine Spermatogenic Stages	5
Identifying Erythrocyte Injury in Toxicology Studies	5
Thank You to Reviewers	5
Deep Learning–Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure	5
Proceedings of the 2022 National Toxicology Program Satellite Symposium	5
Red Deads, Ghosts, and the Afterlife: A Guide to Neuronal Cell Death	4
Deep Learning Methodology for Quantification of Normal Pancreas Structures	4
Neurobiomarkers: Basic Aspects and Their Relevance in Nonclinical Studies	4
Assessing the Carcinogenicity of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, in Rodents	4
Toxicologic Pathology Forum: Tissue Evaluation in Nonclinical Toxicity Studies for Prophylactic Vaccines	4
Mass Spectrometry Imaging Distinguishes Biliary Toxicants on the Basis of Cellular Distribution	4
Reliable Identification of Alpha2u-Globulin and Lysozyme Accumulation in Rat Kidney by Label-Free MALDI Mass Spectrometry Imaging	4
An Overview of Nonclinical and Clinical Liver Toxicity Associated With AAV Gene Therapy	4
Immunotoxicology From a Pathology Perspective: A Continuing Education Course Presented at the Annual STP Meeting in Baltimore, MD, Held June 16-19, 2024	4
Scientific and Regulatory Policy Committee Best Practices: Recommended (“Best”) Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies	4
Effects of LRRK2 Inhibitors in Nonhuman Primates	3
Case Report: Glioneuronal Hamartoma in the Cerebral Cortex of a Juvenile Cynomolgus Monkey ( Macaca fascicularis )	3
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing	3
IT/QA and Regulatory Aspects of Digital Pathology: Results of the 8th ESTP International Workshop	3
Histology Atlas of the Developing Mouse Respiratory System From Prenatal Day 9.0 Through Postnatal Day 30	3
Nonproliferative and Proliferative Lesions of the Rat and Mouse Female Reproductive System: Revised INHAND Terms for Ovarian Sex Cord/Stromal Lesions	3
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review—Are We There Yet?	3
Scientific and Regulatory Policy Committee Points to Consider: Integration of Clinical Pathology Data With Anatomic Pathology Data in Nonclinical Toxicology Studies	3
Corrigendum to Histology Atlas of the Developing Mouse Placenta	3
Historical Control Data of Spontaneous Pathological Findings in C57BL/6J Mice Used in 18-Month Dietary Carcinogenicity Assays	3
Absolute Versus Relative Approaches to Severity Scoring of Histopathologic Findings in Pre-Clinical Toxicology Studies: What’s the Difference, and How, When, and Why This Matters	3
Toxicologic Pathology Forum*: Opinion on New Technologies and Trends Disrupting Drug Discovery and Development: How Can the Next Generation of Toxicologic Pathologists Be Prepared for Evolving Roles?	3
Immune-Mediated Liver Effects Associated With Administration of a Human Anti-IL-21 Receptor Antibody (ATR-107) in Rats	3
Meeting Report Session 3: Neurobiomarkers STP 44th Annual Symposium 2025 Development and Utility of Neurobiomarkers in Nonclinical Toxicology Studies	3
Post-Pandemic Pathology Practice	3
Toxicologic Pathology Forum: Opinion on Approaches for Reporting Toxic and Adverse Dose Levels in Nonclinical Toxicology Studies Supporting the Development of Anticancer Pharmaceuticals	3
Toxicologic Pathology Forum*: Opinion on the Future of Histopathology Using Whole Slide Images in Toxicologic Pathology of Preclinical Studies and Its Successful Implementation in Compliance With Good	3
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review—Diving Head-First Into the Deep Digital Pool!	3
Pathological Characterization of Spontaneous AA Amyloidosis in Microminipigs	3
Historical Control Background Incidence of Spontaneous Neoplastic Lesions of Sprague-Dawley Rats in 104-Week Toxicity Studies	3
Toxicologic Pathology Forum*: Opinion on Qualitative Severity Descriptors to Express Magnitude of Changes in Clinical Pathology Endpoints in Nonclinical Toxicity Studies	3
To Clot or Not to Clot: Deepening Our Understanding of Alterations in the Hemostatic System	3

Toxicologic Pathology Forum*: Opinion on Remote Digital Toxicologic Pathology in Practice—Lessons From a Digital Team and Approach to Scientific Quality, Flexibility, and Well-Being