OOIR: Observatory of International Research

Papers

(The TQCC of Toxicologic Pathology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
A Pathologist’s Guide to Non-clinical Safety Assessment of Adoptive Cell Therapy Products	91
Early-Onset Asymptomatic Polypoid Cystitis in Two Adolescent Male Beagle Dogs	32
Guide for Combining Primary Tumors for Statistical Analysis in Rodent Carcinogenicity Studies	30
Spontaneous Findings in the Reproductive System of Sexually Mature Male Cynomolgus Macaques	26
Kidney Effects by Alternative Classes of Medicines in Patients and Relationship to Effects in Nonclinical Toxicity Studies	26
Toxicologic Pathology Forum Opinion: Interpretation of Gliosis in the Brain and Spinal Cord Observed During Nonclinical Safety Studies	21
In Utero Exposure to 3,3′,4,4′, 5-Pentachlorobiphenyl Dose-Dependently Induces N-butyl-4-(hydroxybutyl) Nitrosamine in Rats With Urinary Bladder Carcinoma	18
Toxicologic Pathology Forum: Opinion on Interpretive Challenges for Procedure-Related Effects Associated With Direct Central Nervous System Delivery of Oligonucleotides to Rodents, Dogs, and Nonhuman	18
Retraction Notice: “Role of Quercetin in Preventing Thioacetamide-Induced Liver Injury in Rats”	16
Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats	13
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity	13
Scientific and Regulatory Policy Committee Points to Consider: Proposal and Recommendations to Reduce Euthanasia of Control Nonhuman Primates in Nonclinical Toxicity Studies	13
Toxicologic Pathology Forum: mRNA Vaccine Safety–Separating Fact From Fiction	13
Toxicologic Pathology Forum*: Opinion on Assessing and Communicating Adversity for Implantable Medical Devices	13
Society of Toxicologic Pathology Nonhuman Primate Special Interest Group: Idiopathic Femoral Head Chondrolysis in Nonclinical Research Macaques	12
Scientific and Regulatory Policy Committee Points to Consider for Medical Device Implant Site Evaluation in Nonclinical Studies	12
Difference in the Mechanism of Iron Overload–Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats	10
Toxicologic Pathology Forum*: Opinion on the Interpretation of Statistical Significance Testing Results From Anatomic and Clinical Pathology Data in Nonclinical Safety Studies	10
Interpretative Challenges in Animal Studies: Review of Case Studies and Implications for Toxicologic Pathology	10
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studi	9
Virtual Control Groups in Non-clinical Toxicity Studies: Impacts on Toxicologic Clinical Pathology Data Interpretation	8
Opinion on the Optimal Histologic Evaluation of the Bone Marrow in Nonclinical Toxicity Studies	8
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice	8
Organ Weights in Relation to Age and Sex in Cynomolgus Monkeys (Macaca fascicularis)	8
Cardiac Rhabdomyoma in Four Göttingen Minipigs	7

Selected Resources for Pathology Evaluation of Nonhuman Primates in Nonclinical Safety Assessment	7
Comparative Impact of Various Fasting Periods on the Welfare of Sprague-Dawley Rats With or Without Supplementation	7
Applications of Cell-Based Protein Array Technology to Preclinical Safety Assessment of Biological Products	6
Identifying Erythrocyte Injury in Toxicology Studies	6
Neurofilament Light Chain: A Translational Safety Biomarker for Drug-Induced Peripheral Neurotoxicity	6
Deep Learning Methodology for Quantification of Normal Pancreas Structures	6
Toxicologic Pathology Forum: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry	6
Proceedings of the 2022 National Toxicology Program Satellite Symposium	5
Neurobiomarkers: Basic Aspects and Their Relevance in Nonclinical Studies	5
Bortezomib-Induced Ovarian Toxicity in Mice	5
Scientific and Regulatory Policy Committee Best Practices: Recommended (“Best”) Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies	5
Morphologic Features and Deep Learning–Based Analysis of Canine Spermatogenic Stages	5
Deep Learning–Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure	5
Toxicologic Pathology Forum: Tissue Evaluation in Nonclinical Toxicity Studies for Prophylactic Vaccines	5
Idiopathic Aneurysms of the Ascending Aorta in the Mouse and Rat	5
Thank You to Reviewers	5
Safety and Performance Evaluation of Su2ura Approximation, a New Suturing Device, in Pigs	5
Possible Cytoprotection of Low Dose Lipopolysaccharide in Rat Thioacetamide-Induced Liver Lesions, Focusing on the Analyses of Hepatic Macrophages and Autophagy	5
Immunotoxicology From a Pathology Perspective: A Continuing Education Course Presented at the Annual STP Meeting in Baltimore, MD, Held June 16-19, 2024	5
Histology Atlas of the Developing Mouse Respiratory System From Prenatal Day 9.0 Through Postnatal Day 30	4
IT/QA and Regulatory Aspects of Digital Pathology: Results of the 8th ESTP International Workshop	4
Reliable Identification of Alpha2u-Globulin and Lysozyme Accumulation in Rat Kidney by Label-Free MALDI Mass Spectrometry Imaging	4
Historical Control Data of Spontaneous Pathological Findings in C57BL/6J Mice Used in 18-Month Dietary Carcinogenicity Assays	4
Corrigendum to Histology Atlas of the Developing Mouse Placenta	4
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review—Are We There Yet?	4
Toxicologic Pathology Forum*: Opinion on the Future of Histopathology Using Whole Slide Images in Toxicologic Pathology of Preclinical Studies and Its Successful Implementation in Compliance With Good	4
Scientific and Regulatory Policy Committee Points to Consider: Integration of Clinical Pathology Data With Anatomic Pathology Data in Nonclinical Toxicology Studies	4
Assessing the Carcinogenicity of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, in Rodents	4
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review—Diving Head-First Into the Deep Digital Pool!	4
Effects of LRRK2 Inhibitors in Nonhuman Primates	4
Case Report: Glioneuronal Hamartoma in the Cerebral Cortex of a Juvenile Cynomolgus Monkey ( Macaca fascicularis )	4
Mass Spectrometry Imaging Distinguishes Biliary Toxicants on the Basis of Cellular Distribution	4
An Overview of Nonclinical and Clinical Liver Toxicity Associated With AAV Gene Therapy	4
Red Deads, Ghosts, and the Afterlife: A Guide to Neuronal Cell Death	4