Toxicologic Pathology

Papers
(The TQCC of Toxicologic Pathology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
Postnatal Hepatobiliary and Gastrointestinal Systems Development and Impact on ADME98
Expression of Concern71
Deep Learning–Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure24
A Pathologist’s Guide to Non-clinical Safety Assessment of Adoptive Cell Therapy Products22
Toxicologic Pathology Forum Opinion: Interpretation of Gliosis in the Brain and Spinal Cord Observed During Nonclinical Safety Studies20
Results of the European Society of Toxicologic Pathology Survey on the Use of Artificial Intelligence in Toxicologic Pathology17
Evaluation of Adrenal Cortical Function in Neonatal and Weanling Laboratory Beagle Dogs17
Methodologies and Emerging Technologies for the Evaluation of the Hematopoietic System16
A Critical Assessment of the Requirement for a Single Time Point Vaginal Cytology on the Day of Necropsy in Rats16
Translational Relevance of Rodent Models to Predict Human Liver Disease14
Guide for Combining Primary Tumors for Statistical Analysis in Rodent Carcinogenicity Studies13
Symmetric Dimethylarginine Is a Sensitive Biomarker of Glomerular Injury in Rats11
Intra-abdominal Abscesses in Two Göttingen Minipigs11
Immunosuppression Profile of CFZ533 (Iscalimab), a Non-Depleting Anti-CD40 Antibody, and the Presence of Opportunistic Infections in a Rhesus Monkey Toxicology Study10
Kidney Effects by Alternative Classes of Medicines in Patients and Relationship to Effects in Nonclinical Toxicity Studies10
Whole Slide Imaging (WSI) in Toxicologic Pathology10
Early-Onset Asymptomatic Polypoid Cystitis in Two Adolescent Male Beagle Dogs9
Antisense Oligonucleotide-Related Macrovesicular Vacuolation of Hippocampal Neurons in Nonhuman Primates9
Mitigating Nephrotoxicity Risks and Ranking Drug Candidates Using MALDI Mass Spectrometry Imaging: A Case Study9
Toxicity and Local Tolerance of COVID- eVax, a Plasmid DNA Vaccine for SARS-CoV-2, Delivered by Electroporation9
Morphologic Features and Deep Learning–Based Analysis of Canine Spermatogenic Stages8
Does Geographical Origin of Long-Tailed Macaques (Macaca fascicularis) Matter in Drug Safety Assessment?: A Literature Review and Proposed Conclusion8
Toxicologic Pathology Forum: Opinion on Interpretive Challenges for Procedure-Related Effects Associated With Direct Central Nervous System Delivery of Oligonucleotides to Rodents, Dogs, and Nonhuman 8
Characterizing Antisense Oligonucleotide-Induced Histopathology Findings in Spinal Cord of Mauritius Cynomolgus Monkeys by Molecular Localization Investigation8
Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop8
Thank You to Reviewers8
Mucocutaneous Squamous Cell Carcinoma in a Yucatan Minipig7
Scientific and Regulatory Policy Committee Points to Consider* for Determining and Reporting Cause of Death/Moribundity in Non-Rodent Species in Toxicity Studies7
Points to Consider From the ESTP Pathology 2.0 Working Group: Overview on Spatial Omics Technologies Supporting Drug Discovery and Development7
Recent Neuropathology Concepts7
Development of a Deep Learning Tool to Support the Assessment of Thyroid Follicular Cell Hypertrophy in the Rat7
Spontaneous Findings in the Reproductive System of Sexually Mature Male Cynomolgus Macaques7
Can Historical Control Group Data Be Used to Replace Concurrent Controls in Animal Studies?6
Safety and Performance Evaluation of Su2ura Approximation, a New Suturing Device, in Pigs6
Historical Control Background Incidence of Spontaneous Nonneoplastic Lesions of Sprague Dawley Rats in 104-Week Carcinogenicity Studies6
Proceedings of the 2022 National Toxicology Program Satellite Symposium6
Biocompatible Solutions: Evaluating the Safety of Repeated Intra-Articular Injections of pMPCylated Liposomes for Knee Osteoarthritis Therapy in Rat Models5
Adeno-Associated Virus-Mediated Dorsal Root Ganglion Toxicity in the New Zealand White Rabbit5
Opinion on the Use of Animal Models in Nonclinical Safety Assessment: Pros and Cons5
Intrathecal sc-AAV9-CB-GFP: Systemic Distribution Predominates Following Single-Dose Administration in Cynomolgus Macaques5
Scientific and Regulatory Policy Committee Best Practices: Recommended (“Best”) Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies5
European Society of Toxicologic Pathology—Pathology 2.0 Mass Spectrometry Imaging Special Interest Group: Mass Spectrometry Imaging in Diagnostic and Toxicologic Pathology for Label-Free Detection of 4
Scientific and Regulatory Policy Committee Points to Consider: Primary Digital Histopathology Evaluation and Peer Review for Good Laboratory Practice (GLP) Nonclinical Toxicology Studies4
Chronic Inhalation Exposure to Antimony Trioxide Exacerbates the MAPK Signaling in Alveolar Bronchiolar Carcinomas in B6C3F1/N Mice4
Retraction Notice: “Role of Quercetin in Preventing Thioacetamide-Induced Liver Injury in Rats”4
Neuropathology Evaluation in Juvenile Toxicity Studies in Rodents: Comparison of Developmental Neurotoxicity Studies for Chemicals With Juvenile Animal Studies for Pediatric Pharmaceuticals4
Brief Synopsis: “Instruction Manual for Juvenile Clinical Pathology”4
Toxicologic Pathology Forum: mRNA Vaccine Safety–Separating Fact From Fiction4
Integration of Chromogenic RNAscope In Situ Hybridization for Target Validation in Drug Discovery3
Possible Cytoprotection of Low Dose Lipopolysaccharide in Rat Thioacetamide-Induced Liver Lesions, Focusing on the Analyses of Hepatic Macrophages and Autophagy3
Nervous System Sampling for General Toxicity and Neurotoxicity Studies in the Laboratory Minipig With Emphasis on the Göttingen Minipig3
Toxicologic Pathology Forum: Tissue Evaluation in Nonclinical Toxicity Studies for Prophylactic Vaccines3
Toxicity and Local Tolerance of a Novel Spike Protein RBD Vaccine Against SARS-CoV-2, Produced Using the C1 Thermothelomyces Heterothallica Protein Expression Platform3
Artificial Intelligence in Toxicological Pathology: Quantitative Evaluation of Compound-Induced Follicular Cell Hypertrophy in Rat Thyroid Gland Using Deep Learning Models3
Causes of Mortality and Profile of Spontaneous Tumors in Young CD-1 Mice3
Scientific and Regulatory Policy Committee Points to Consider: Biological Sample Retention From Nonclinical Toxicity Studies3
Mass Spectrometry Imaging Distinguishes Biliary Toxicants on the Basis of Cellular Distribution3
Complex In Vitro Model Characterization for Context of Use in Toxicologic Pathology: Use Cases by Collaborative Teams of Biologists, Bioengineers, and Pathologists3
Multiplexed siRNA Immunoassay Unveils Spatial and Quantitative Dimensions of siRNA Function, Abundance, and Localization In Vitro and In Vivo3
Modeling SARS-CoV-2: Comparative Pathology in Rhesus Macaque and Golden Syrian Hamster Models3
Characterization of Pulmonary Pathology in the Golden Syrian Hamster Model of COVID-19 Using Micro-Computed Tomography3
Assessment of Mouse Liver Histopathology Following Exposure to HFPO-DA With Emphasis on Understanding Mechanisms of Hepatocellular Death3
Proceedings of the 2023 Annual Scientific Meeting of the French Society of Toxicologic Pathology (SFPT) on Preclinical Development and Therapeutic Applications of mRNA-Based Technologies3
Idiopathic Aneurysms of the Ascending Aorta in the Mouse and Rat3
Effects of 0.5% and 2.0% Sodium Lauryl Sulfate in Male CD-1 Mice From a 3-Month Oral Gavage Toxicity Study3
Society of Toxicologic Pathology Neuropathology Interest Group Article: Neuropathologic Findings in Nonhuman Primates Associated With Administration of Biomolecule-Based Test Articles3
Assessing the Carcinogenicity of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, in Rodents3
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