OOIR: Observatory of International Research

Papers

(The TQCC of Toxicologic Pathology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Kidney Effects by Alternative Classes of Medicines in Patients and Relationship to Effects in Nonclinical Toxicity Studies	109
A Pathologist’s Guide to Non-clinical Safety Assessment of Adoptive Cell Therapy Products	74
Toxicity and Local Tolerance of COVID- eVax, a Plasmid DNA Vaccine for SARS-CoV-2, Delivered by Electroporation	28
Symmetric Dimethylarginine Is a Sensitive Biomarker of Glomerular Injury in Rats	26
Early-Onset Asymptomatic Polypoid Cystitis in Two Adolescent Male Beagle Dogs	22
Guide for Combining Primary Tumors for Statistical Analysis in Rodent Carcinogenicity Studies	20
Spontaneous Findings in the Reproductive System of Sexually Mature Male Cynomolgus Macaques	19
Toxicologic Pathology Forum: Opinion on Interpretive Challenges for Procedure-Related Effects Associated With Direct Central Nervous System Delivery of Oligonucleotides to Rodents, Dogs, and Nonhuman	17
Toxicologic Pathology Forum Opinion: Interpretation of Gliosis in the Brain and Spinal Cord Observed During Nonclinical Safety Studies	16
Retraction Notice: “Role of Quercetin in Preventing Thioacetamide-Induced Liver Injury in Rats”	14
Toxicologic Pathology Forum: mRNA Vaccine Safety–Separating Fact From Fiction	14
In Utero Exposure to 3,3′,4,4′, 5-Pentachlorobiphenyl Dose-Dependently Induces N-butyl-4-(hydroxybutyl) Nitrosamine in Rats With Urinary Bladder Carcinoma	12
Scientific and Regulatory Policy Committee Points to Consider: Proposal and Recommendations to Reduce Euthanasia of Control Nonhuman Primates in Nonclinical Toxicity Studies	12
Artificial Intelligence in Toxicological Pathology: Quantitative Evaluation of Compound-Induced Follicular Cell Hypertrophy in Rat Thyroid Gland Using Deep Learning Models	12
Toxicologic Pathology Forum*: Opinion on Assessing and Communicating Adversity for Implantable Medical Devices	11
Magnitude of Urine Albumin and KIM-1 Changes Can be Used to Differentiate Glomerular Injury From Tubular Injury in Rats	10
Scientific and Regulatory Policy Committee Points to Consider for Medical Device Implant Site Evaluation in Nonclinical Studies	10
Scientific and Regulatory Policy Committee Points to Consider: Nonclinical Research and Development of In Vivo Gene Therapy Products, Emphasizing Adeno-Associated Virus Vectors	10
Difference in the Mechanism of Iron Overload–Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats	10
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity	10
Society of Toxicologic Pathology Nonhuman Primate Special Interest Group: Idiopathic Femoral Head Chondrolysis in Nonclinical Research Macaques	10
Toxicologic Pathology Forum*: Opinion on the Interpretation of Statistical Significance Testing Results From Anatomic and Clinical Pathology Data in Nonclinical Safety Studies	9
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studi	9
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice	9
Interpretative Challenges in Animal Studies: Review of Case Studies and Implications for Toxicologic Pathology	9

Selected Resources for Pathology Evaluation of Nonhuman Primates in Nonclinical Safety Assessment	8
Opinion on the Optimal Histologic Evaluation of the Bone Marrow in Nonclinical Toxicity Studies	8
Organ Weights in Relation to Age and Sex in Cynomolgus Monkeys (Macaca fascicularis)	8
Comparative Impact of Various Fasting Periods on the Welfare of Sprague-Dawley Rats With or Without Supplementation	7
Neurofilament Light Chain: A Translational Safety Biomarker for Drug-Induced Peripheral Neurotoxicity	7
Identifying Erythrocyte Injury in Toxicology Studies	7
Applications of Cell-Based Protein Array Technology to Preclinical Safety Assessment of Biological Products	7
Cardiac Rhabdomyoma in Four Göttingen Minipigs	7
Virtual Control Groups in Non-clinical Toxicity Studies: Impacts on Toxicologic Clinical Pathology Data Interpretation	7
Toxicologic Pathology Forum: A Roadmap for Building State-of-the-Art Digital Image Data Resources for Toxicologic Pathology in the Pharmaceutical Industry	6
Proceedings of the 2022 National Toxicology Program Satellite Symposium	6
Idiopathic Aneurysms of the Ascending Aorta in the Mouse and Rat	5
Scientific and Regulatory Policy Committee Points to Consider: Biological Sample Retention From Nonclinical Toxicity Studies	5
Thank You to Reviewers	5
Toxicologic Pathology Forum: Tissue Evaluation in Nonclinical Toxicity Studies for Prophylactic Vaccines	5
Safety and Performance Evaluation of Su2ura Approximation, a New Suturing Device, in Pigs	5
Morphologic Features and Deep Learning–Based Analysis of Canine Spermatogenic Stages	5
Possible Cytoprotection of Low Dose Lipopolysaccharide in Rat Thioacetamide-Induced Liver Lesions, Focusing on the Analyses of Hepatic Macrophages and Autophagy	5
Deep Learning–Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure	5
Brief Synopsis: “Instruction Manual for Juvenile Clinical Pathology”	4
Mass Spectrometry Imaging Distinguishes Biliary Toxicants on the Basis of Cellular Distribution	4
Bortezomib-Induced Ovarian Toxicity in Mice	4
Immunotoxicology From a Pathology Perspective: A Continuing Education Course Presented at the Annual STP Meeting in Baltimore, MD, Held June 16-19, 2024	4
Scientific and Regulatory Policy Committee Best Practices: Recommended (“Best”) Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies	4
Assessing the Carcinogenicity of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, in Rodents	4
Effects of LRRK2 Inhibitors in Nonhuman Primates	3
Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling	3
Corrigendum to Histology Atlas of the Developing Mouse Placenta	3
Toxicologic Pathology Forum: Opinion on Approaches for Reporting Toxic and Adverse Dose Levels in Nonclinical Toxicology Studies Supporting the Development of Anticancer Pharmaceuticals	3
Proceedings of the 2021 National Toxicology Program Satellite Symposium	3
An Overview of Nonclinical and Clinical Liver Toxicity Associated With AAV Gene Therapy	3
The Impact of Functional and Structural Maturation of the Kidney on Susceptibility to Drug and Chemical Toxicity in Neonatal Rodents	3
Phthalate Toxicity in Rats and Its Relation to Testicular Dysgenesis Syndrome in Humans	3
Case Report: Glioneuronal Hamartoma in the Cerebral Cortex of a Juvenile Cynomolgus Monkey ( Macaca fascicularis )	3
Pathological Characterization of Spontaneous AA Amyloidosis in Microminipigs	3
Characterization of Urothelial Inclusions in Male Wistar Han Rats Treated Orally With the Novel α2A-Adrenoceptor Agonist Tasipimidine	3
Toxicologic Pathology Forum: Opinion on Digital Primary Read and Peer Review—Diving Head-First Into the Deep Digital Pool!	3
Historical Control Data of Spontaneous Pathological Findings in C57BL/6J Mice Used in 18-Month Dietary Carcinogenicity Assays	3
IT/QA and Regulatory Aspects of Digital Pathology: Results of the 8th ESTP International Workshop	3
Scientific and Regulatory Policy Committee Points to Consider: Integration of Clinical Pathology Data With Anatomic Pathology Data in Nonclinical Toxicology Studies	3
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing	3
Scientific and Regulatory Policy Committee Points to Consider: Fixation, Trimming, and Sectioning of Nonrodent Eyes and Ocular Tissues for Examination in Ocular and General Toxicity Studies	3
Historical Control Background Incidence of Spontaneous Neoplastic Lesions of Sprague-Dawley Rats in 104-Week Toxicity Studies	3
Neurobiomarkers: Basic Aspects and Their Relevance in Nonclinical Studies	3