American Journal of Physiology-Endocrinology and Metabolism

Article	Citations
COVID-19 pandemic, coronaviruses, and diabetes mellitus	554
Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes	148
New insights into purine metabolism in metabolic diseases: role of xanthine oxidoreductase activity	132
COVID-19 and vitamin D—Is there a link and an opportunity for intervention?	102
Bilirubin as a metabolic hormone: the physiological relevance of low levels	90
Melatonin ameliorates excessive PINK1/Parkin-mediated mitophagy by enhancing SIRT1 expression in granulosa cells of PCOS	89
DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K/Akt/mTOR signaling pathway	81
COVID-19-associated SIADH: a clue in the times of pandemic!	77
Mitochondrial-derived peptides in energy metabolism	66
Blueberry proanthocyanidins and anthocyanins improve metabolic health through a gut microbiota-dependent mechanism in diet-induced obese mice	61
Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity	60
COVID-19 endocrinopathy with hindsight from SARS	52
An update on brown adipose tissue biology: a discussion of recent findings	51
Biological plausibility for interactions between dietary fat, resveratrol, ACE2, and SARS-CoV illness severity	50
Sex-derived attributes contributing to SARS-CoV-2 mortality	50
Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8	48
Can phytotherapy with polyphenols serve as a powerful approach for the prevention and therapy tool of novel coronavirus disease 2019 (COVID-19)?	46
The controversial role of IL-6 in adipose tissue on obesity-induced dysregulation of glucose metabolism	46
Is there an impact of the COVID-19 pandemic on male fertility? The ACE2 connection	46
Cholesterol: A new game player accelerating vasculopathy caused by SARS-CoV-2?	44
Differential intestinal and oral microbiota features associated with gestational diabetes and maternal inflammation	43
Endothelial dysfunction due to selective insulin resistance in vascular endothelium: insights from mechanistic modeling	41
Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases	40
A ketogenic diet combined with exercise alters mitochondrial function in human skeletal muscle while improving metabolic health	39
SARS-CoV-2: influence of phosphate and magnesium, moderated by vitamin D, on energy (ATP) metabolism and on severity of COVID-19	37

Insulin Action in the Brain regulates both Central and Peripheral Functions	37
Vitamin D and lumisterol novel metabolites can inhibit SARS-CoV-2 replication machinery enzymes	37
Type 2 diabetes: one disease, many pathways	35
100th anniversary of the discovery of insulin perspective: insulin and adipose tissue fatty acid metabolism	34
Diabetic ferroptosis plays an important role in triggering on inflammation in diabetic wound	34
Mitochondrial dysfunction plays a key role in the development of neurodegenerative diseases in diabetes	34
IGF-1 inhibits MPTP/MPP+-induced autophagy on dopaminergic neurons through the IGF-1R/PI3K-Akt-mTOR pathway and GPER	34
High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling	34
Irisin counteracts high glucose and fatty acid-induced cytotoxicity by preserving the AMPK-insulin receptor signaling axis in C2C12 myoblasts	33
β-Hydroxybutyrate is reduced in humans with obesity-related NAFLD and displays a dose-dependent effect on skeletal muscle mitochondrial respiration in vitro	32
Apigenin promotes osteogenic differentiation of mesenchymal stem cells and accelerates bone fracture healing via activating Wnt/β-catenin signaling	32
Alanine, arginine, cysteine, and proline, but not glutamine, are substrates for, and acute mediators of, the liver-α-cell axis in female mice	32
Caloric restriction recovers impaired β-cell-β-cell gap junction coupling, calcium oscillation coordination, and insulin secretion in prediabetic mice	32
Glucose-dependent activation, activity, and deactivation of beta cell networks in acute mouse pancreas tissue slices	30
Is GLUT4 translocation the answer to exercise-stimulated muscle glucose uptake?	30
Role of enhanced glucocorticoid receptor sensitivity in inflammation in PTSD: insights from computational model for circadian-neuroendocrine-immune interactions	30
Glucagon-like peptide-1 alleviates diabetic kidney disease through activation of autophagy by regulating AMP-activated protein kinase-mammalian target of rapamycin pathway	29
Resveratrol mediates the miR-149/HMGB1 axis and regulates the ferroptosis pathway to protect myocardium in endotoxemia mice	29
Mitochondria-associated ER membranes in glucose homeostasis and insulin resistance	28
Insulin Signaling In the Heart	28
Lower oxygen consumption and Complex I activity in mitochondria isolated from skeletal muscle of fetal sheep with intrauterine growth restriction	27
Paracrine and autocrine control of insulin secretion in human islets: evidence and pending questions	27
Adipose tissue macrophage burden, systemic inflammation, and insulin resistance	27
Diabetic ketoacidosis and COVID-19: what have we learned so far?	27
Aerobic exercise training regulates serum extracellular vesicle miRNAs linked to obesity to promote their beneficial effects in mice	27
Diet during early life defines testicular lipid content and sperm quality in adulthood	27
Maternal and neonatal response to COVID-19	26
MOTS-c reduces myostatin and muscle atrophy signaling	26
Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis	26
Obesity and chronic kidney disease	25
DPP4 deletion in adipose tissue improves hepatic insulin sensitivity in diet-induced obesity	25
Luteolin alleviates polycystic ovary syndrome in rats by resolving insulin resistance and oxidative stress	25
Supplementation of a propionate-producing consortium improves markers of insulin resistance in an in vitro model of gut-liver axis	25
Persistent organic pollutants and β-cell toxicity: a comprehensive review	25
Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes	25
The emerging role of lactate as a mediator of exercise-induced appetite suppression	25
NOD2 in hepatocytes engages a liver-gut axis to protect against steatosis, fibrosis, and gut dysbiosis during fatty liver disease in mice	24
Loss of CTRP4 alters adiposity and food intake behaviors in obese mice	24
Androgen aggravates liver fibrosis by activation of NLRP3 inflammasome in CCl4-induced liver injury mouse model	24
Fecal microbiota transplantation from high caloric-fed donors alters glucose metabolism in recipient mice, independently of adiposity or exercise status	24
Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms	24
Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver disease	23
Higher protein intake during resistance training does not potentiate strength, but modulates gut microbiota, in middle-aged adults: a randomized control trial	23
Can spironolactone be used to prevent COVID-19-induced acute respiratory distress syndrome in patients with hypertension?	23
Relative lipid oxidation associates directly with mitochondrial fusion phenotype and mitochondria-sarcoplasmic reticulum interactions in human skeletal muscle	23
SARS-CoV-2 perturbs the renin-angiotensin system and energy metabolism	23
Human blood contains circulating cell-free mitochondria, but are they really functional?	22
Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40	22
Macrophage HIF-1α mediates obesity-related adipose tissue dysfunction via interleukin-1 receptor-associated kinase M	22
Exploring the link between vitamin D and clinical outcomes in COVID-19	21

Estradiol treatment or modest exercise improves hepatic health and mitochondrial outcomes in female mice following ovariectomy	20
Overexpression of histone deacetylase SIRT1 exerts an antiangiogenic role in diabetic retinopathy via miR-20a elevation and YAP/HIF1α/VEGFA depletion	20
The contribution of the mouse tail to thermoregulation is modest	20
Improved recovery from skeletal muscle damage is largely unexplained by myofibrillar protein synthesis or inflammatory and regenerative gene expression pathways	20
Transcription factor EB and TFE3: new metabolic coordinators mediating adaptive responses to exercise in skeletal muscle?	20
Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women	19
Relation of diet-induced thermogenesis to brown adipose tissue activity in healthy men	19
GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism	19
c-Myc overexpression increases ribosome biogenesis and protein synthesis independent of mTORC1 activation in mouse skeletal muscle	19
Neurodegeneration in juvenile Iberian pigs with diet-induced nonalcoholic fatty liver disease	19
RANKL induces beige adipocyte differentiation in preadipocytes	19
Increased vascular permeability and severe renal tubular damage after ischemia-reperfusion injury in mice lacking adiponectin or T-cadherin	19
Considerations and challenges of islet transplantation and future therapies on the horizon	19
Gut-to-brain signals in feeding control	18
Metabolic responses to intermittent hypoxia are regulated by sex and estradiol in mice	18
Deficiency of arcuate nucleus kisspeptin results in postpubertal central hypogonadism	18
Comparison of the effects of soluble corn fiber and fructooligosaccharides on metabolism, inflammation, and gut microbiome of high-fat diet-fed mice	18
Statins activate the NLRP3 inflammasome and impair insulin signaling via p38 and mTOR	18
Effects of carbohydrate restriction on postprandial glucose metabolism, β-cell function, gut hormone secretion, and satiety in patients with Type 2 diabetes	18
Testosterone supplementation upregulates androgen receptor expression and translational capacity during severe energy deficit	18
β-Cell autophagy in the pathogenesis of type 1 diabetes	18
Long-term, high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration	18
Reply to Jakovac and to Rocha et al.: Can vitamin D prevent or manage COVID-19 illness?	17
Proteome analysis of human adipocytes identifies depot-specific heterogeneity at metabolic control points	17
Emerging roles of extracellular vesicles in the intercellular communication for exercise-induced adaptations	17
Combined effects of a ketogenic diet and exercise training alter mitochondrial and peroxisomal substrate oxidative capacity in skeletal muscle	17
Exercise and estrogen: common pathways in Alzheimer's disease pathology	17
CTRP12 ablation differentially affects energy expenditure, body weight, and insulin sensitivity in male and female mice	17
Glucagon-like peptide-1 receptor mediates the beneficial effect of liraglutide in an acute lung injury mouse model involving the thioredoxin-interacting protein	17
Sleeve gastrectomy enhances glucose utilization and remodels adipose tissue independent of weight loss	17
The promising future of insulin therapy in diabetes mellitus	16
Downregulation of microRNA-873 attenuates insulin resistance and myocardial injury in rats with gestational diabetes mellitus by upregulating IGFBP2	16
Oral and intestinal microbial features in pregnant women with hypothyroidism and their correlations with pregnancy outcomes	16
Fight against fibrosis in adipose tissue remodeling	16
Holistic characterization of single-hepatocyte transcriptome responses to high-fat diet	16
Downregulated microRNA-130b-5p prevents lipid accumulation and insulin resistance in a murine model of nonalcoholic fatty liver disease	16
Astragaloside IV ameliorates preeclampsia-induced oxidative stress through the Nrf2/HO-1 pathway in a rat model	15
GRP94 regulates M1 macrophage polarization and insulin resistance	15
Worsening baroreflex sensitivity on progression to type 2 diabetes: localized vs. systemic inflammation and role of antidiabetic therapy	15
Impact of prolonged fasting on insulin secretion, insulin action, and hepatic versus whole body insulin secretion disposition indices in healthy young males	15
Utilization of biomarkers as predictors of skeletal muscle mitochondrial content after physiological intervention and in clinical settings	15
The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism	15
Involvement of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in mPRα (PAQR7)-mediated progesterone induction of vascular smooth muscle relaxation	15
Sugar causes obesity and metabolic syndrome in mice independently of sweet taste	15
The neuronal (pro)renin receptor and astrocyte inflammation in the central regulation of blood pressure and blood glucose in mice fed a high-fat diet	15
Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1	15
Intestinal NAPE-PLD contributes to short-term regulation of food intake via gut-to-brain axis	15
Peripheral and central regulation of insulin by the intestine and microbiome	15
Separating insulin-mediated and non-insulin-mediated glucose uptake during and after aerobic exercise in type 1 diabetes	15
Skeletal muscle mitochondrial adaptations induced by long-term cigarette smoke exposure	15
HDL-apoA-I kinetics in response to 16 wk of exercise training in men with nonalcoholic fatty liver disease	14
Myostatin deficiency not only prevents muscle wasting but also improves survival in septic mice	14
Mitochondrial transformations in the aging human placenta	14
Adrenal insufficiency in the COVID-19 era	14
Metformin prevents endothelial oxidative stress and microvascular insulin resistance during obesity development in male rats	14
Genetically increasing flux through β-oxidation in skeletal muscle increases mitochondrial reductive stress and glucose intolerance	14
Role of creatine and creatine kinase in UCP1-independent adipocyte thermogenesis	14
Reproductive and metabolic adaptation to multistressor training in women	14
Regulation of ANGPTL8 in liver and adipose tissue by nutritional and hormonal signals and its effect on glucose homeostasis in mice	14
The effect of acute dual SGLT1/SGLT2 inhibition on incretin release and glucose metabolism after gastric bypass surgery	14
Mesenchymal stem cells alleviate palmitic acid-induced endothelial-to-mesenchymal transition by suppressing endoplasmic reticulum stress	14
Dietary carbohydrates modulate metabolic and β-cell adaptation to high-fat diet-induced obesity	14
High-resolution analysis of the cytosolic Ca2+ events in β cell collectives in situ	14
Chronic high-fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice	13
Local myostatin inhibition improves skeletal muscle glucose uptake in insulin-resistant high-fat diet-fed mice	13
Increased postprandial nonesterified fatty acid efflux from adipose tissue in prediabetes is offset by enhanced dietary fatty acid adipose trapping	13
Skeletal muscle transcriptome response to a bout of endurance exercise in physically active and sedentary older adults	13
Elevated plasma lactate levels via exogenous lactate infusion do not alter resistance exercise-induced signaling or protein synthesis in human skeletal muscle	13
miR-30a targets gene networks that promote browning of human and mouse adipocytes	13
Hydroxysteroid (17β) dehydrogenase 12 is essential for metabolic homeostasis in adult mice	13
Amelioration of bone fragility by pulsed electromagnetic fields in type 2 diabetic KK-Ay mice involving Wnt/β-catenin signaling	13
Sex differences in fat taste responsiveness are modulated by estradiol	13
NUPR1 preserves insulin secretion of pancreatic β-cells during inflammatory stress by multiple low-dose streptozotocin and high-fat diet	13
Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity	13
Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner	12
The prorenin receptor and its soluble form contribute to lipid homeostasis	12
GPR40 deficiency is associated with hepatic FAT/CD36 upregulation, steatosis, inflammation, and cell injury in C57BL/6 mice	12
Uncoupling protein-1 expression does not protect mice from diet-induced obesity	12
Inosine, gut microbiota, and cancer immunometabolism	12
High-glucose mixed-nutrient meal ingestion impairs skeletal muscle microvascular blood flow in healthy young men	12

Cumulative insulin resistance and hyperglycemia with arterial stiffness and carotid IMT progression in 1,779 adolescents: a 9-yr longitudinal cohort study	12
Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice	12
Levels of β-klotho determine the thermogenic responsiveness of adipose tissues: involvement of the autocrine action of FGF21	12
Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs	12