OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Endocrinology and Metabolism is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
The impact of glucagon to support postabsorptive glucose flux and glycemia in healthy rats and its attenuation in male Zucker diabetic fatty rats	124
Comparison of an oral mixed meal plus arginine and intravenous glucose, GLP-1 plus arginine to unmask residual islet function in longstanding type 1 diabetes	92
Corrigendum for Zhang et al., volume 325, 2023, p. E363–E375	51
Duodenal mucosal resurfacing with a GLP-1 receptor agonist increases postprandial unconjugated bile acids in patients with insulin-dependent type 2 diabetes	47
Liver Androgen Receptor Knockout Attenuates High-Fructose Diet-Induced Glucose Dysregulation in Female Mice	43
Quantitative estimation of disposition index from postprandial glucose data across the spectrum of glucose tolerance	39
Identification of newly synthetized proteins by mass spectrometry to understand palmitate-induced early cellular changes in pancreatic islets	36
Mammary tumor development induces perturbation of liver glucose metabolism with inflammation and fibrosis	35
O-linked N-acetylglucosamine modification is essential for physiological adipose expansion induced by high-fat feeding	35
A reduction of skeletal muscle DHA content does not result in impaired whole body glucose tolerance or skeletal muscle basal insulin signaling in otherwise healthy mice	35
Human skeletal muscle methylome after low-carbohydrate energy-balanced exercise	34
Human liver afferent and efferent nerves revealed by 3-D/Airyscan super-resolution imaging	34
Persistent organic pollutants and β-cell toxicity: a comprehensive review	28
Metabolic labeling unveils alterations in the turnover of HDL-associated proteins during diabetes progression in mice	28
Editorial Board	27
Early complete weaning in mice induces hepatic steatosis, which is associated with changes in phospholipids, metabolites, gene expression, and epigenome	23
Inhibition of protein kinase C-α and activation of ezrin by Lactobacillus acidophilus restore Na⁺/H⁺ exchange activity and fluid absorption in db/db mice	23
α- or β-Adrenergic blockade does not affect transplanted islet cell responses to hypoglycemia in type 1 diabetes	23
BRCA1 influences whole body metabolism in humanized mice	21
Phosphorylation of AS160-serine 704 is not essential for exercise-increase in insulin-stimulated glucose uptake by skeletal muscles from female or male rats	21
More than meets the islet: aligning nutrient and paracrine inputs with hormone secretion in health and disease	21
A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice	20
Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency	20
NADPH oxidase 4-derived hydrogen peroxide counterbalances testosterone-induced endothelial dysfunction and migration	20
Epigenetic reprogramming of H3K4me3 in adipose-derived stem cells by HFS diet consumption leads to a disturbed transcriptomic profile in adipocytes	19

Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review	19
Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata	19
Genetic ablation of the preptin-coding portion of Igf2 impairs pancreatic function in female mice	19
Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan	19
Breaking the vicious cycle: bitter compounds targeting metabolic defects and inflammation in Alzheimer’s disease	18
Metabolic pathways and male fertility: exploring the role of Sertoli cells in energy homeostasis and spermatogenesis	18
Muscle fiber type-specific autophagy responses following an overnight fast and mixed meal ingestion in human skeletal muscle	18
Role of complexin 2 in the regulation of hormone secretion from the islet of Langerhans	18
In utero exposure to maternal diabetes exacerbates dietary sodium intake-induced endothelial dysfunction by activating cyclooxygenase 2-derived prostanoids	18
Retraction for Jiang et al., volume 304, 2012, p. E74–E86	17
Metabolic shifts in ratio of ucOcn to cOcn toward bone resorption contribute to age-dependent bone loss in male mice	17
Heme-based oxygen gasoreceptors	17
Relationship Between Aerobic Fitness and Adipose Tissue Insulin Resistance	17
Adipocyte traits limiting cellular insulin responsiveness and glucose transport	16
Intestinal FFA3 mediates obesogenic effects in mice on a Western diet	16
Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers	16
Genealogical Rabson–Mendenhall syndrome caused by INSR gene mutation	16
Synergistic effects of glucose tolerance and BMI on cardiovascular events and all-cause mortality in a healthy population: CA.ME.LI.A study 7 years follow-up	15
Hypothalamus and brainstem circuits in the regulation of glucose homeostasis	15
Effects of acute changes in fasting glucose and free fatty acid concentrations on indices of β-cell function and glucose metabolism in subjects without diabetes	15
Mechanisms of spinophilin-dependent pancreas dysregulation in obesity	15
Spatiotemporally quantitative in vivo imaging of mitochondrial fatty acid β-oxidation at cellular-level resolution in mice	15
Defective muscle ketone body oxidation disrupts BCAA catabolism by altering mitochondrial branched-chain aminotransferase	15
Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction	15
Breakfast consumption does not rapidly increase liver or muscle glycogen content in well-trained cyclists	15
Muscle wasting and the response to exercise in lung-injured mice is not primarily driven through the glucocorticoid axis	14
Deconstructing interindividual variability in energy metabolism: implications for metabolic health	14
Chronic succinate exposure does not cause liver injury	14
Increased gut serotonin production in response to bisphenol A structural analogs may contribute to their obesogenic effects	14
A physiologic increase in brain glucagon action alters the hepatic gluconeogenic/glycogenolytic ratio but not glucagon’s overall effect on glucose production	14
T-cell factor 7L2 is a novel regulator of osteoblast functions that acts in part by modulation of hypoxia signaling	14
Roux-en-Y gastric bypass alleviates kidney inflammation and improves kidney function in db/db mice by activating TLCA/TGR5 pathway	13
Sex-specific difference in intestinal glucose metabolism is associated with sexually dimorphic postprandial lactate shuttle and glucose homeostasis in mice	13
Female and male C57BL/6J offspring exposed to maternal obesogenic diet develop altered hypothalamic energy metabolism in adulthood	13
Paternal obesity decreases infant MSC mitochondrial functional capacity	13
Brown adipose tissue metabolism in women is dependent on ovarian status	13
Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury	13
Markers of mitochondrial function and oxidative metabolism in skeletal muscle do not display intrinsic circadian regulation in female mice	13
A new C-peptide minimal model to assess β-cell responsiveness to glucagon in individuals with and without type 2 diabetes	13
Reply to Lund et al.	12
Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability	12
Inhibition of the endocannabinoid system reverses obese phenotype in aged mice and partly restores skeletal muscle function	12
Generation and characterization of a mouse model for one anastomosis gastric bypass surgery	12
Effects of follicle-stimulating hormone on energy balance and tissue metabolic health after loss of ovarian function	12
L-type Calcium Channel Blockade Worsens Glucose Tolerance and β-Cell Function in C57BL6/J Mice Exposed to Intermittent Hypoxia	12
Absence of Slc39a14/Zip14 in mouse pancreatic beta cells results in hyperinsulinemia	12
Effect of ghrelin on glucose tolerance, gut hormones, appetite, and food intake after sleeve gastrectomy	11
Greater reliance on glycolysis is associated with lower mitochondrial substrate oxidation and insulin sensitivity in infant myogenic MSCs	11
Potential role of skeletal muscle glycerophosphocholine in response to altered fluid balance in humans: an in vivo nuclear magnetic resonance study	11
Assessment of the incretin effect in healthy subjects: concordance between clamp and OGTT methods	11

Key questions and gaps in understanding adipose tissue macrophages and early-life metabolic programming	11
Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes	11
Constitutive loss of kynurenine-3-monooxygenase changes circulating kynurenine metabolites without affecting systemic energy metabolism	11
Central lipid sensing pathways contribute to the control of puberty and its alterations in conditions of obesity	11
Roles of circadian clocks in macrophage metabolism: implications in inflammation and metabolism of lipids, glucose, and amino acids	11
Disruption of hepatic mitochondrial pyruvate and amino acid metabolism impairs gluconeogenesis and endurance exercise capacity in mice	11
Endoplasmic reticulum stress in pancreatic β cells induces incretin desensitization and β-cell dysfunction via ATF4-mediated PDE4D expression	11
Fasting potentiates insulin-mediated glucose uptake in rested and prior-contracted rat skeletal muscle	10
Pantothenate protects against obesity via brown adipose tissue activation	10
Sugar type and route of delivery influence insulin and glucose-dependent insulinotropic polypeptide responses in rats	10
Obesity wars: may the smell be with you	10
Increasing maternal glucose concentrations is insufficient to restore placental glucose transfer in chorionic somatomammotropin RNA interference pregnancies	10
Extracellular flux analyses reveal differences in mitochondrial PBMC metabolism between high-fit and low-fit females	10
Endothelial β1-integrins are necessary for microvascular function and glucose uptake	10
Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice	10
Downregulation of the mitochondrial tRNA-derived fragment mt-tRF-Leu^TAA enhances skeletal muscle insulin sensitivity	10
Brown adipose tissue is not associated with cachexia or increased mortality in a retrospective study of patients with cancer	10
Activation of β-adrenergic receptor signaling prevents glucocorticoid-induced obesity and adipose tissue dysfunction in male mice	10
Ethnic differences in postprandial fatty acid trafficking and utilization between overweight and obese White European and Black African-Caribbean men	10
Thermoneutral housing does not accelerate metabolic dysfunction-associated fatty liver disease in male or female C57Bl/6J mice fed a Western diet	9
Deletion of complement factor 5 amplifies glucose intolerance in obese male but not female mice	9
Vitamin E treatment in insulin-deficient diabetic rats reduces cardiac arrhythmias and mortality during severe hypoglycemia	9
The enduring metabolic improvement of combining dual amylin and calcitonin receptor agonist and semaglutide treatments in a rat model of obesity and diabetes	9
Hepatic mTORC2 compensates for loss of adipose mTORC2 in mediating energy storage and glucose homeostasis	9
An isoproteic cocoa butter-based ketogenic diet fails to improve glucose homeostasis and promote weight loss in obese mice	9
Sedentary time associates detrimentally and physical activity beneficially with metabolic flexibility in adults with metabolic syndrome	9
The nervous system and adipose tissues: a tale of dialogues	9
Distinct endothelial gene responses to acute exercise in skeletal muscle	9
Fat and not sugar as the determining factor for gut microbiota changes, obesity, and related metabolic disorders in mice	9
Maintenance of thermogenic adipose tissues despite loss of the H3K27 acetyltransferases p300 or CBP	9
Effect of in utero metformin exposure in gestational diabetes mellitus on infant mesenchymal stem cell metabolism	9
The influence of interleukin-27 on metabolic fitness in a murine neonatal model of bacterial sepsis	9
The role of postprandial thermogenesis in the development of impaired glucose tolerance and type II diabetes	9
Hepatocyte HIF-2α aggravates NAFLD by inducing ferroptosis through increasing extracellular iron	9
Duration of morning hyperinsulinemia determines hepatic glucose uptake and glycogen storage later in the day	9
Association of aerobic fitness and body composition with protein and major lipid class composition of high-density lipoprotein	8
Hydrolyzed collagen supplementation prior to resistance exercise augments collagen synthesis in a dose-response manner in resistance-trained, middle-aged men	8
Higher AMPK activation in mouse oxidative compared with glycolytic muscle does not correlate with LKB1 or CaMKKβ expression	8
Corrigendum for Subramanian et al., volume 326, 2024, p. E182–E205	8
The effect of repeated hot water immersion on insulin sensitivity, heat shock protein 70, and inflammation in individuals with type 2 diabetes mellitus	8
Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats	8
The antiemetic actions of GIP receptor agonism	8
17α-Estradiol alleviates high-fat diet-induced inflammatory and metabolic dysfunction in skeletal muscle of male and female mice	8
PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice	8
Enhanced quantification of α-cell suppression by hyperglycemia using a high-sensitivity glucagon assay	8
Corrigendum for Li et al., volume 308, 2014, p. E257–E269	8
Discovery of a novel regulator, 3β-sulfate-5-cholestenoic acid, of lipid metabolism and inflammation	8
Cold acclimation and pioglitazone combined increase thermogenic capacity of brown and white adipose tissues but this does not translate into higher energy expenditure in mice	8
Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models	8
Understanding how pre- and probiotics affect the gut microbiome and metabolic health	8
AQP1- A regulatory factor associated with brown adipose tissue-silencing to combat obesity and metabolic disease	8
Untargeted metabolomic profiling identifies serum metabolites associated with type 2 diabetes in a cross-sectional study of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study	8
Corrigendum for Waterman et al., volume 327, 2024, p. E655–E667	8
Maternal genetics and diet modulate vitamin A homeostasis of the offspring and affect the susceptibility to obesity in adulthood in mice	7
Metformin prevents endothelial oxidative stress and microvascular insulin resistance during obesity development in male rats	7
Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function	7
Menstrual cycle phase differences in myofiber damage and macrophage infiltration following electrical stimulation-induced muscle injury	7
Circulating interleukin-33 levels in obesity and type 2 diabetes: a systematic review and meta-analysis	7
Disruption of neuromedin B receptor improves mitochondrial oxidative phosphorylation capacity in gastrocnemius muscle of female mice	7
Class B1 GPCRs: insights into multireceptor pharmacology for the treatment of metabolic disease	7
Effects of 1,144 km of road cycling performed in 7 days: a cardiometabolic imaging study	7
Perineuronal nets’ role in metabolism	7
Plasma complement system markers and their association with cardiometabolic risk factors: an ethnic comparison of White European and Black African men	7
Glucagon increases plasma levels of cyclic AMP responses in mice and humans, and this may be independent of MASLD	7
The hormonal profile in women using combined monophasic oral contraceptive pills varies across the pill cycle: a temporal analysis of serum endogenous and exogenous hormones using liquid chromatograph	7
Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner	7
Low-frequency ultrasound reverses insulin resistance and diabetes-induced changes in the muscle transcriptome in aged mice	7
Energy expenditure due to gluconeogenesis in pathological conditions of insulin resistance	7
17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice	7
Gut lactate increases circulating l-Lac-Phe and key metabolites linked to GLP-1 and human health	7
CYP1A1/1A2 enzymes mediate glucose homeostasis and insulin secretion in mice in a sex-specific manner	7
Adipocyte-specific inactivation of NAMPT, a key NAD⁺ biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging	7
Resilience of the mitochondrial reticulum in aging	7
Intramuscular diacylglycerol accumulates with acute hyperinsulinemia in insulin-resistant phenotypes	7
Advanced glycation end products induce skeletal muscle atrophy and insulin resistance via activating ROS-mediated ER stress PERK/FOXO1 signaling	7
The evolution of steatosis and fibrosis in mice on a MASH-inducing diet and the effects of housing temperature	7
Development of a synbiotic that protects against ovariectomy-induced trabecular bone loss	7
Protein intake counteracts alcohol intake in the regulation of postprandial FGF21 secretion in humans	7