OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Endocrinology and Metabolism is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
A reduction of skeletal muscle DHA content does not result in impaired whole body glucose tolerance or skeletal muscle basal insulin signaling in otherwise healthy mice	87
The impact of glucagon to support postabsorptive glucose flux and glycemia in healthy rats and its attenuation in male Zucker diabetic fatty rats	85
Comparison of an oral mixed meal plus arginine and intravenous glucose, GLP-1 plus arginine to unmask residual islet function in longstanding type 1 diabetes	81
Identification of newly synthetized proteins by mass spectrometry to understand palmitate-induced early cellular changes in pancreatic islets	81
Corrigendum for Zhang et al., volume 325, 2023, p. E363–E375	79
Mammary tumor development induces perturbation of liver glucose metabolism with inflammation and fibrosis	63
Muscle damaging eccentric exercise attenuates disuse-induced declines in daily myofibrillar protein synthesis and transiently prevents muscle atrophy in healthy men	45
O-linked N-acetylglucosamine modification is essential for physiological adipose expansion induced by high-fat feeding	45
Duodenal mucosal resurfacing with a GLP-1 receptor agonist increases postprandial unconjugated bile acids in patients with insulin-dependent type 2 diabetes	44
Human skeletal muscle methylome after low-carbohydrate energy-balanced exercise	44
Transorgan short-chain fatty acid fluxes in the fasted and postprandial state in the pig	40
Human liver afferent and efferent nerves revealed by 3-D/Airyscan super-resolution imaging	38
Mito-Mendelian interactions alter in vivo glucose metabolism and insulin sensitivity in healthy mice	38
Persistent organic pollutants and β-cell toxicity: a comprehensive review	36
CB1Rs in VMH neurons regulate glucose homeostasis but not body weight	35
Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity	34
More than meets the islet: aligning nutrient and paracrine inputs with hormone secretion in health and disease	31
A modest change in housing temperature alters whole body energy expenditure and adipocyte thermogenic capacity in mice	31
Inhibition of protein kinase C-α and activation of ezrin by Lactobacillus acidophilus restore Na⁺/H⁺ exchange activity and fluid absorption in db/db mice	30
Metabolic labeling unveils alterations in the turnover of HDL-associated proteins during diabetes progression in mice	28
α- or β-Adrenergic blockade does not affect transplanted islet cell responses to hypoglycemia in type 1 diabetes	28
Phosphorylation of AS160-serine 704 is not essential for exercise-increase in insulin-stimulated glucose uptake by skeletal muscles from female or male rats	28
BRCA1 influences whole body metabolism in humanized mice	27
NADPH oxidase 4-derived hydrogen peroxide counterbalances testosterone-induced endothelial dysfunction and migration	26
Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review	25

Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency	24
Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan	23
Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata	23
In utero exposure to maternal diabetes exacerbates dietary sodium intake-induced endothelial dysfunction by activating cyclooxygenase 2-derived prostanoids	22
Saturated fat ingestion stimulates proatherogenic inflammation in polycystic ovary syndrome	21
Genetic ablation of the preptin-coding portion of Igf2 impairs pancreatic function in female mice	21
Metabolic shifts in ratio of ucOcn to cOcn toward bone resorption contribute to age-dependent bone loss in male mice	20
Epigenetic reprogramming of H3K4me3 in adipose-derived stem cells by HFS diet consumption leads to a disturbed transcriptomic profile in adipocytes	20
Mechanisms of spinophilin-dependent pancreas dysregulation in obesity	19
Intestinal FFA3 mediates obesogenic effects in mice on a Western diet	19
Muscle fiber type-specific autophagy responses following an overnight fast and mixed meal ingestion in human skeletal muscle	19
Neonatal IL-4 exposure decreases adipogenesis of male rats into adulthood	19
Synergistic effects of glucose tolerance and BMI on cardiovascular events and all-cause mortality in a healthy population: CA.ME.LI.A study 7 years follow-up	18
Adipocyte traits limiting cellular insulin responsiveness and glucose transport	17
Spatiotemporally quantitative in vivo imaging of mitochondrial fatty acid β-oxidation at cellular-level resolution in mice	17
Heme-based oxygen gasoreceptors	17
Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction	17
Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers	17
Effects of acute changes in fasting glucose and free fatty acid concentrations on indices of β-cell function and glucose metabolism in subjects without diabetes	17
A new C-peptide minimal model to assess β-cell responsiveness to glucagon in individuals with and without type 2 diabetes	17
Roux-en-Y gastric bypass alleviates kidney inflammation and improves kidney function in db/db mice by activating TLCA/TGR5 pathway	17
Hypothalamus and brainstem circuits in the regulation of glucose homeostasis	17
Retraction for Jiang et al., volume 304, 2012, p. E74–E86	17
Defective muscle ketone body oxidation disrupts BCAA catabolism by altering mitochondrial branched-chain aminotransferase	17
Paternal obesity decreases infant MSC mitochondrial functional capacity	16
Obesity protects against sepsis-induced and norepinephrine-induced white adipose tissue browning	16
A physiologic increase in brain glucagon action alters the hepatic gluconeogenic/glycogenolytic ratio but not glucagon’s overall effect on glucose production	15
Brown adipose tissue metabolism in women is dependent on ovarian status	15
Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury	15
Female and male C57BL/6J offspring exposed to maternal obesogenic diet develop altered hypothalamic energy metabolism in adulthood	14
Increased gut serotonin production in response to bisphenol A structural analogs may contribute to their obesogenic effects	14
Deconstructing interindividual variability in energy metabolism: implications for metabolic health	14
Chronic succinate exposure does not cause liver injury	14
T-cell factor 7L2 is a novel regulator of osteoblast functions that acts in part by modulation of hypoxia signaling	14
Muscle wasting and the response to exercise in lung-injured mice is not primarily driven through the glucocorticoid axis	14
The transcriptional coregulator CITED2 suppresses expression of IRS-2 and impairs insulin signaling in endothelial cells	13
Absence of Slc39a14/Zip14 in mouse pancreatic beta cells results in hyperinsulinemia	13
Roles of circadian clocks in macrophage metabolism: implications in inflammation and metabolism of lipids, glucose, and amino acids	13
L-type Calcium Channel Blockade Worsens Glucose Tolerance and β-Cell Function in C57BL6/J Mice Exposed to Intermittent Hypoxia	13
Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability	13
Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes	13
Disruption of hepatic mitochondrial pyruvate and amino acid metabolism impairs gluconeogenesis and endurance exercise capacity in mice	13
Central lipid sensing pathways contribute to the control of puberty and its alterations in conditions of obesity	13
Assessment of the incretin effect in healthy subjects: concordance between clamp and OGTT methods	13
Key questions and gaps in understanding adipose tissue macrophages and early-life metabolic programming	13
Endothelial β1-integrins are necessary for microvascular function and glucose uptake	13
Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect	12
Greater reliance on glycolysis is associated with lower mitochondrial substrate oxidation and insulin sensitivity in infant myogenic MSCs	12
Exercise effect on insulin-dependent and insulin-independent glucose utilization in healthy individuals and individuals with type 1 diabetes: a modeling study	12
Inhibition of the endocannabinoid system reverses obese phenotype in aged mice and partly restores skeletal muscle function	12

Effect of ghrelin on glucose tolerance, gut hormones, appetite, and food intake after sleeve gastrectomy	12
Effects of follicle-stimulating hormone on energy balance and tissue metabolic health after loss of ovarian function	12
Potential role of skeletal muscle glycerophosphocholine in response to altered fluid balance in humans: an in vivo nuclear magnetic resonance study	12
Reply to Lund et al.	12
Constitutive loss of kynurenine-3-monooxygenase changes circulating kynurenine metabolites without affecting systemic energy metabolism	12
Endoplasmic reticulum stress in pancreatic β cells induces incretin desensitization and β-cell dysfunction via ATF4-mediated PDE4D expression	12
Generation and characterization of a mouse model for one anastomosis gastric bypass surgery	12
Activation of β-adrenergic receptor signaling prevents glucocorticoid-induced obesity and adipose tissue dysfunction in male mice	11
Ethnic differences in postprandial fatty acid trafficking and utilization between overweight and obese White European and Black African-Caribbean men	11
Central GLP-1 contributes to improved cognitive function and brain glucose uptake after duodenum-jejunum bypass on obese and diabetic rats	11
Increasing maternal glucose concentrations is insufficient to restore placental glucose transfer in chorionic somatomammotropin RNA interference pregnancies	11
Thermoneutral housing does not accelerate metabolic dysfunction-associated fatty liver disease in male or female C57Bl/6J mice fed a Western diet	11
Effect of in utero metformin exposure in gestational diabetes mellitus on infant mesenchymal stem cell metabolism	11
Pantothenate protects against obesity via brown adipose tissue activation	11
Obesity wars: may the smell be with you	11
Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids	10
Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice	10
Sedentary time associates detrimentally and physical activity beneficially with metabolic flexibility in adults with metabolic syndrome	10
An isoproteic cocoa butter-based ketogenic diet fails to improve glucose homeostasis and promote weight loss in obese mice	10
The role of postprandial thermogenesis in the development of impaired glucose tolerance and type II diabetes	10
Extracellular flux analyses reveal differences in mitochondrial PBMC metabolism between high-fit and low-fit females	10
Fasting potentiates insulin-mediated glucose uptake in rested and prior-contracted rat skeletal muscle	10
Vitamin E treatment in insulin-deficient diabetic rats reduces cardiac arrhythmias and mortality during severe hypoglycemia	10
Duration of morning hyperinsulinemia determines hepatic glucose uptake and glycogen storage later in the day	10
Deletion of complement factor 5 amplifies glucose intolerance in obese male but not female mice	10
The influence of interleukin-27 on metabolic fitness in a murine neonatal model of bacterial sepsis	10
Brown adipose tissue is not associated with cachexia or increased mortality in a retrospective study of patients with cancer	10
Hepatic mTORC2 compensates for loss of adipose mTORC2 in mediating energy storage and glucose homeostasis	10
Maintenance of thermogenic adipose tissues despite loss of the H3K27 acetyltransferases p300 or CBP	9
PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice	9
The nervous system and adipose tissues: a tale of dialogues	9
Higher AMPK activation in mouse oxidative compared with glycolytic muscle does not correlate with LKB1 or CaMKKβ expression	9
Maternal genetics and diet modulate vitamin A homeostasis of the offspring and affect the susceptibility to obesity in adulthood in mice	9
Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity	9
The enduring metabolic improvement of combining dual amylin and calcitonin receptor agonist and semaglutide treatments in a rat model of obesity and diabetes	9
Vitamin D and lumisterol novel metabolites can inhibit SARS-CoV-2 replication machinery enzymes	9
Fat and not sugar as the determining factor for gut microbiota changes, obesity, and related metabolic disorders in mice	9
Loss of growth hormone signaling in the mouse germline or in adulthood reduces islet mass and alters islet function with notable sex differences	9
Effects of 1,144 km of road cycling performed in 7 days: a cardiometabolic imaging study	9
Understanding how pre- and probiotics affect the gut microbiome and metabolic health	9
Hepatocyte HIF-2α aggravates NAFLD by inducing ferroptosis through increasing extracellular iron	9
Reproductive and metabolic adaptation to multistressor training in women	9
17α-Estradiol alleviates high-fat diet-induced inflammatory and metabolic dysfunction in skeletal muscle of male and female mice	9
Chronic AT₁ blockade improves hyperglycemia by decreasing adipocyte inflammation and decreasing hepatic PCK1 and G6PC1 expression in obese rats	9
Corrigendum for Subramanian et al., volume 326, 2024, p. E182–E205	9
Untargeted metabolomic profiling identifies serum metabolites associated with type 2 diabetes in a cross-sectional study of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study	8
Insulin secretion and action and the response of endogenous glucose production to a lack of glucagon suppression in nondiabetic subjects	8
Discovery of a novel regulator, 3β-sulfate-5-cholestenoic acid, of lipid metabolism and inflammation	8
Hydrolyzed collagen supplementation prior to resistance exercise augments collagen synthesis in a dose-response manner in resistance-trained, middle-aged men	8
Energy expenditure due to gluconeogenesis in pathological conditions of insulin resistance	8
Development of a synbiotic that protects against ovariectomy-induced trabecular bone loss	8
Disruption of neuromedin B receptor improves mitochondrial oxidative phosphorylation capacity in gastrocnemius muscle of female mice	8
Leptin in the VMH contributes to the initial overconsumption of palatable diets by rats	8
Enhanced quantification of α-cell suppression by hyperglycemia using a high-sensitivity glucagon assay	8
Class B1 GPCRs: insights into multireceptor pharmacology for the treatment of metabolic disease	8
17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice	8
c-Myc overexpression increases ribosome biogenesis and protein synthesis independent of mTORC1 activation in mouse skeletal muscle	8
Perineuronal nets’ role in metabolism	8
The effect of repeated hot water immersion on insulin sensitivity, heat shock protein 70, and inflammation in individuals with type 2 diabetes mellitus	8
Cold acclimation and pioglitazone combined increase thermogenic capacity of brown and white adipose tissues but this does not translate into higher energy expenditure in mice	8
The antiemetic actions of GIP receptor agonism	8
CYP1A1/1A2 enzymes mediate glucose homeostasis and insulin secretion in mice in a sex-specific manner	8