OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Gastrointestinal and Liver Physiology is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
The mechanism and treatment of gastrointestinal symptoms in patients with COVID-19	115
A story of liver and gut microbes: how does the intestinal flora affect liver disease? A review of the literature	81
Effects of dietary components on intestinal permeability in health and disease	80
Biomarkers for assessment of intestinal permeability in clinical practice	71
Production of hydrogen sulfide by the intestinal microbiota and epithelial cells and consequences for the colonic and rectal mucosa	60
Understanding chemotherapy-induced intestinal mucositis and strategies to improve gut resilience	57
Dynamics of the preterm gut microbiome in health and disease	55
Short-chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo	53
Mitochondrial oxidative injury: a key player in nonalcoholic fatty liver disease	51
Exercise and intestinal permeability: another form of exercise-induced hormesis?	49
Bile acid metabolism and circadian rhythms	47
hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223	43
Gut microbiota and renin-angiotensin system: a complex interplay at local and systemic levels	43
Gut leakage enhances sepsis susceptibility in iron-overloaded β-thalassemia mice through macrophage hyperinflammatory responses	43
The gastric conduction system in health and disease: a translational review	40
The role of butyrate in surgical and oncological outcomes in colorectal cancer	40
Gut microbiome-based supervised machine learning for clinical diagnosis of inflammatory bowel diseases	39
Interstitial cells of Cajal and human colon motility in health and disease	38
Sarcopenia in chronic liver disease: mechanisms and countermeasures	36
BDNF rescues aging-associated internal anal sphincter dysfunction	34
The serotonin reuptake transporter is reduced in the epithelium of active Crohn’s disease and ulcerative colitis	34
Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia by enhancing vagal efferent activity	33
Early life interaction between the microbiota and the enteric nervous system	33
Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease	31
Lipopolysaccharides transport during fat absorption in rodent small intestine	30

Ridinilazole, a narrow spectrum antibiotic for treatment of Clostridioides difficile infection, enhances preservation of microbiota-dependent bile acids	28
A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood	28
Severe acute pancreatitis: capillary permeability model linking systemic inflammation to multiorgan failure	26
An overview of deregulated lipid metabolism in nonalcoholic fatty liver disease with special focus on lysosomal acid lipase	26
Microbiota on biotics: probiotics, prebiotics, and synbiotics to optimize growth and metabolism	26
Antibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity	26
Modulation of pharyngeal swallowing by bolus volume and viscosity	25
Hyperthermia-induced changes in liver physiology and metabolism: a rationale for hyperthermic machine perfusion	25
Visceral myopathy: clinical syndromes, genetics, pathophysiology, and fall of the cytoskeleton	24
Metabolic consequences of ileal interruption of the enterohepatic circulation of bile acids	24
HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models	23
Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels	23
Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice	23
Human intestinal enteroids as a model ofClostridioides difficile-induced enteritis	23
Histamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans	23
Spinal neuron-glia-immune interaction in cross-organ sensitization	22
Dynamics of the enterohepatic circulation of bile acids in healthy humans	22
Microbial metabolite indole-3-propionic acid supplementation does not protect mice from the cardiometabolic consequences of a Western diet	22
Bile acid detergency: permeability, inflammation, and effects of sulfation	22
Neural control of gut homeostasis	22
Lipid droplets disrupt mechanosensing in human hepatocytes	22
Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors	21
Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function	21
Advances in colonic motor complexes in mice	21
The American lifestyle-induced obesity syndrome diet in male and female rodents recapitulates the clinical and transcriptomic features of nonalcoholic fatty liver disease and nonalcoholic steatohepati	21
Brain-gut communication: vagovagal reflexes interconnect the two “brains”	20
Validation of noninvasive body-surface gastric mapping for detecting gastric slow-wave spatiotemporal features by simultaneous serosal mapping in porcine	20
Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip	20
Noninvasive stratification of nonalcoholic fatty liver disease by whole transcriptome cell-free mRNA characterization	20
Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts	20
Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model	19
microRNA-382 suppresses the progression of pancreatic cancer through the PI3K/Akt signaling pathway by inhibition of Anxa3	19
Mast cell effects on esophageal smooth muscle and their potential role in eosinophilic esophagitis and achalasia	19
Shifting into high gear: how interstitial cells of Cajal change the motility pattern of the developing intestine	19
Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling	19
Vitamin D/VDR signaling inhibits colitis by suppressing HIF-1α activation in colonic epithelial cells	19
Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model	19
Hyaluronic acid promotes Lgr5⁺ stem cell proliferation and crypt fission through TLR4 and PGE₂ transactivation of EGFR	18
Amygdala microglia modify neuronal plasticity via complement C1q/C3-CR3 signaling and contribute to visceral pain in a rat model	18
Role of excretion in manganese homeostasis and neurotoxicity: a historical perspective	18
Role of circadian rhythm and autonomic nervous system in liver function: a hypothetical basis for improving the management of hepatic encephalopathy	18
MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury	18
Talk about micromanaging! Role of microRNAs in intestinal barrier function	18
Bacterial and eukaryotic extracellular vesicles and nonalcoholic fatty liver disease: new players in the gut-liver axis?	17
Limosilactobacillus reuteri and Lacticaseibacillus rhamnosus GG differentially affect gut microbes and metabolites in mice with Treg deficiency	17
Obesity and its effects on the esophageal mucosal barrier	17
Intestinal secretory mechanisms and diarrhea	17
The gut-brain axis: spatial relationship between spinal afferent nerves and 5-HT-containing enterochromaffin cells in mucosa of mouse colon	16
Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis	16
Larazotide acetate: a pharmacological peptide approach to tight junction regulation	16

Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel	16
Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice	16
Gastric ablation as a novel technique for modulating electrical conduction in the in vivo stomach	16
Recent advances and health implications of dietary fasting regimens on the gut microbiome	15
Gastrointestinal organoids: a next-generation tool for modeling human development	15
GCSF deficiency attenuates nonalcoholic fatty liver disease through regulating GCSFR-SOCS3-JAK-STAT3 pathway and immune cells infiltration	15
Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis	15
Long noncoding RNA LINC00982 upregulates CTSF expression to inhibit gastric cancer progression via the transcription factor HEY1	15
Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3	15
Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease	15
Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites	15
Sinusoidal endotheliopathy in nonalcoholic steatohepatitis: therapeutic implications	15
Role and mechanisms of exosomal miRNAs in IBD pathophysiology	15
Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves	15
Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels	14
Every breath you take: Impacts of environmental dust exposure on intestinal barrier function–from the gut-lung axis to COVID-19	14
Interleukin-28A induces epithelial barrier dysfunction in CD patient-derived intestinal organoids	14
HOPX⁺ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia	14
Characterization of haustral activity in the human colon	14
Metformin slows liver cyst formation and fibrosis in experimental model of polycystic liver disease	14
Numb negatively regulates the epithelial-to-mesenchymal transition in colorectal cancer through the Wnt signaling pathway	14
Deletion of mucin 2 induces colitis with concomitant metabolic abnormalities in mice	14
Gastric accommodation influences proximal gastric and total gastric emptying in concurrent measurements conducted in healthy volunteers	14
Simulated stool for assessment of anorectal physiology	14
Dietary fat and low fiber in purified diets differently impact the gut-liver axis to promote obesity-linked metabolic impairments	13
Fecal microbiome and bile acid metabolome in adult short bowel syndrome	13
Fungi, host immune response, and tumorigenesis	12
Critical appraisal of the mechanisms of gastrointestinal and hepatobiliary infection by COVID-19	12
Long-term trans-inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acid	12
Cellular maps of gastrointestinal organs: getting the most from tissue clearing	12
Xenobiotic receptors and the regulation of intestinal homeostasis: harnessing the chemical output of the intestinal microbiota	12
Microbial metabolites: cause or consequence in gastrointestinal disease?	12
Myostatin in combination with creatine phosphokinase or albumin may differentiate patients with cirrhosis and sarcopenia	12
Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice	12
Liver-on-a-chip devices: the pros and cons of complexity	12
Nutritional, pharmacological, and environmental programming of NAFLD in early life	11
NRG4-ErbB4 signaling represses proinflammatory macrophage activity	11
PPARα agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and β-catenin signaling	11
DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids	11
TNF-α, IL-17, and IL-22 production in the rectal mucosa of nonceliac wheat sensitivity patients: role of adaptive immunity	11
Targeted ablation of gastric pacemaker sites to modulate patterns of bioelectrical slow wave activation and propagation in an anesthetized pig model	11
Reabsorption of bile acids regulated by FXR-OATP1A2 is the main factor for the formation of cholesterol gallstone	11
Role of an active reserve stem cell subset of enteroendocrine cells in intestinal stem cell dynamics and the genesis of small intestinal neuroendocrine tumors	11
Impaired 25-hydroxylation of vitamin D in liver injury suppresses intestinal Paneth cell defensins, leading to gut dysbiosis and liver fibrogenesis	11
Autophagy is required during high MUC2 mucin biosynthesis in colonic goblet cells to contend metabolic stress	11
Hepatic macrophage accumulation with aging: cause for concern?	11
Epigenetic regulation of intestinal stem cell differentiation	11
Cellular origins and lineage relationships of the intestinal epithelium	11
Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation	10
Emodin reduces tumor burden by diminishing M2-like macrophages in colorectal cancer	10
The biological clock enhancer nobiletin ameliorates steatosis in genetically obese mice by restoring aberrant hepatic circadian rhythm	10
A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice	10
Intestinal organoids in coculture: redefining the boundaries of gut mucosa ex vivo modeling	10
Musings on the wanderer: What’s new in our understanding of vago-vagal reflexes? VI. Central vagal circuits that control glucose metabolism	10
Assessment of the role of FGF15 in mediating the metabolic outcomes of murine vertical sleeve gastrectomy	10
Arm lean mass determined by dual-energy X-ray absorptiometry is superior to characterize skeletal muscle and predict sarcopenia-related mortality in cirrhosis	10
Gli2-regulated activation of hepatic stellate cells and liver fibrosis by TGF-β signaling	10
Characterization of cytoplasmic lipid droplets in each region of the small intestine of lean and diet-induced obese mice in response to dietary fat	10
Hepatic bile formation: bile acid transport and water flow into the canalicular conduit	10
Involvement of capsaicin-sensitive nerves in the initiation of swallowing evoked by carbonated water in anesthetized rats	10
Long-term normothermic machine preservation of human livers: what is needed to succeed?	10