OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Gastrointestinal and Liver Physiology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Specific binding sites on Rhesus rotavirus capsid protein dictate the method of endocytosis inducing the murine model of biliary atresia	71
Effect of caloric intake and macronutrient composition on intestinal cholesterol absorption and bile acids in patients with obesity	69
Repurposing dried blood spot device technology to examine bile acid profiles in human dried fecal spot samples	61
Mechanical stress-induced connective tissue growth factor plays a critical role in intestinal fibrosis in Crohn’s-like colitis	54
Animal models with characteristics of irritable bowel syndrome with diarrhea: current applications and future perspectives	39
Rhamnogalacturonan promotes intestinal mucosal repair through increased cell migration	39
Functional involvement of the sternohyoid muscle during breathing and swallowing in rats	39
Regional and conditional variability of FXR: new lessons on ileal inflammation and gut barrier functions	37
Lipidomic signatures discriminate subtle hepatic changes in the progression of porcine nonalcoholic steatohepatitis	32
An inulin-type fructan CP-A from Codonopsis pilosula alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics	30
Effects of potassium on laryngeal-induced swallowing rate in rats	30
Retraction for Mancinelli et al., volume 297, 2009, G11–G26	30
Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice	29
Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis	29
Cells and mediators of inflammation as effectors of epithelial repair in the inflamed intestine	26
P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality	26
LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice	25
Manganese efflux transporter SLC30A10 missense polymorphism T95I associated with liver injury retains manganese efflux activity	24
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2	24
Defecation induced by stimulation of sacral S2 spinal root in cats	24
A ganglionic intestinointestinal reflex activated by acute noxious challenge	24
Retraction for Wu et al., volume 294, 2008, p. G918–G927	22
Renalase peptides reduce pancreatitis severity in mice	22
Coffee modulates insulin-hepatocyte nuclear factor-4α-Cyp7b1 pathway and reduces oxysterol-driven liver toxicity in a nonalcoholic fatty liver disease mouse model	21
Mechanisms underlying initiation of propulsion in guinea pig distal colon	21

Contribution of sex hormones to the sexually dimorphic response of colorectal motility to noxious stimuli in rats	21
Mass cytometric analysis of circulating monocyte subsets in a murine model of diabetic gastroparesis	21
Angiotensin receptor blocker alleviates liver fibrosis by altering the mechanotransduction properties of hepatic stellate cells	21
Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT₃ receptors in the proximal colon	21
Gut feelings: the microbiota-gut-brain axis on steroids	21
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression	20
Fluorescein clearance kinetics in blood and bile indicates hepatic ischemia-reperfusion injury in rats	20
Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study	19
Energy status alters intestinal function and the gut microbiota during consecutive days of high energy demands	19
Effect of ingesting a meal and orthostasis on the regulation of splanchnic and systemic hemodynamics and the responsiveness of cardiovascular α₁-adrenoceptors	19
Hysteresis of the Lower Esophageal Sphincter: Relevance to the Pathogenesis of Esophageal Achalasia and its Phenotypes	19
Host-microbial interactions in the esophagus	18
The emerging roles of deep crypt secretory cells in colonic physiology	18
FOXO3: at the crossroads of metabolic, inflammatory, and tumorigenic remodeling in the colon	18
Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms	18
Role of the microbiota-gut-brain axis in postacute COVID syndrome	18
Who’s talking to whom: microbiome-enteric nervous system interactions in early life	18
Autophagy is required during high MUC2 mucin biosynthesis in colonic goblet cells to contend metabolic stress	18
Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis	17
Is intestinal transport dysfunctional in COVID-19-related diarrhea?	17
Are LRRK2 mysteries lurking in the gut?	16
Novel 5-HT₇ receptor antagonists modulate intestinal immune responses and reduce severity of colitis	16
Myostatin in combination with creatine phosphokinase or albumin may differentiate patients with cirrhosis and sarcopenia	16
Blueberry anthocyanins improve liver fibrosis by regulating NCOA4 ubiquitination through TRIM7 to affect ferroptosis of hepatic stellate cells	16
Characterization of mitochondria-associated ER membranes in the enteric nervous system under physiological and pathological conditions	15
Seladelpar combined with complementary therapies improves fibrosis, inflammation, and liver injury in a mouse model of nonalcoholic steatohepatitis	15
Single-cell analyses of human pancreas: characteristics of two populations of acinar cells in chronic pancreatitis	15
A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure	15
Fecal microbiome and bile acid metabolome in adult short bowel syndrome	14
Tissue- and cell-specific properties of enterochromaffin cells affect the fate of tumorigenesis toward nonendocrine adenocarcinoma of the small intestine	14
HOPX⁺ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia	14
Farnesoid X receptor inhibits proinflammatory cytokine-induced epithelial necroptosis in vitro: implications for preservation of intestinal barrier function	14
Gallbladder mucoceles in dogs: a novel form of acquired CFTR dysfunction causing localized cystic fibrosis-like disease	14
Hepatic and intestinal tissue-specific Fxr deficiency alters bile acid homeostasis in female mice	13
Intestinal organoid coculture systems: current approaches, challenges, and future directions	13
Intestinal ultrasound, an underutilized tool for assessing colonic motility	13
Gut neuropeptide involvement in Parkinson’s disease	13
Obesogenic cafeteria diet induces dynamic changes in gut microbiota, reduces myenteric neuron excitability, and impairs gut contraction in mice	13
Retraction for Marzioni et al., volume 284, 2003, G837–G852	13
A novel gene therapy for ARPKD based on CFTR	13
Initiation and severity of experimental pancreatitis are modified by phosphate	12
Inhibited postprandial retrograde cyclic motor pattern in the distal colon of patients with diarrhea-predominant irritable bowel syndrome	12
Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice	12
A simple and effective genotyping workflow for rapid detection of CRISPR genome editing	12
Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity	12
Revisiting the gut-liver axis: gut lymphatic system in liver cirrhosis and portal hypertension	12
Formal degree programs in physiology promote careers of clinical scientists and benefit basic science departments	12
Corrigendum for Ohno et al., volume 298, 2010, p. G63–G73.	12
Intrathecally administered substance P activated the spinal defecation center and enhanced colorectal motility in anesthetized rats	12
ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis	12

Corrigendum for Lastuvkova et al., 2025, volume 328, p. G558–G577	11
Corrigendum for Liu et al., volume 305, 2013, p. G163–G171	11
Cholestenoic acid as endogenous epigenetic regulator decreases hepatocyte lipid accumulation in vitro and in vivo	11
Dynamic functional luminal imaging probe analysis of the anal sphincter opening function during straining in healthy volunteers	11
Exploring the use of panaxynol from American ginseng to combat intestinal inflammation and colon cancer	11
Hypoosmosis alters hepatocyte mitochondrial morphology and induces selective release of carbamoyl phosphate synthetase 1	11
Local tissue response to a C-X-C motif chemokine ligand 12 therapy for fecal incontinence in a rabbit model	11
Short-term and long-term effects of unilateral external carotid artery ligation on orofacial functions in rats	11
Optogenetic activation of the gut-brain axis in freely moving mice using a fully implantable wireless battery-free device	11
Multichannel magnetogastrogram: a clinical marker for pediatric chronic nausea	11
β-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells	11
Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function	11
A modular analysis of bile canalicular function and its implications for cholestasis	11
Hope for the gut: new evidence suggests Western diet damage can be undone	10
Gut microbiota of patients insusceptible to olanzapine-induced fatty liver disease relieves hepatic steatosis in rats	10
Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease	10
Saturated phosphatidic acids induce mTORC1-driven integrated stress response contributing to glucolipotoxicity in hepatocytes	10
Examining enteric nervous system function in rat and mouse: an interspecies comparison of colonic motility	10
Preferential neurogenesis of nitrergic neurons in the myenteric plexus of the DSS-induced colitis mouse colon causes colonic dysmotility in colitis	10
Maternal Western diet increases inflammatory markers and decreases barrier function of offspring in Papio anubis	10
Inhibition of hedgehog signaling ameliorates severity of chronic pancreatitis in experimental mouse models	10
Deleterious impacts of Western diet on jejunum function and health are reversible	10
Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons	10
Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats	10
Stress during pregnancy alters hepatic renin-angiotensin system and redox homeostasis in a sex- and age-specific manner	10
Deacetylation of Notch1 by SIRT1 contributes to HBsAg- and HBeAg-mediated M2 macrophage polarization	10
Targeting serotonin signaling in the gut to limit colitis via 5-HT₇ receptor antagonism	9
Feeding intolerance after pediatric cardiac surgery is associated with dysbiosis, barrier dysfunction, and reduced short-chain fatty acids	9
PPARα agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and β-catenin signaling	9
Early-life fecal microbiome and metabolome dynamics in response to an intervention with infant formula containing specific prebiotics and postbiotics	9
Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease	9
Gastrointestinal dysmotility in rodent models of Parkinson’s disease	9
Goblet cell hyperplasia is not epithelial-autonomous in the Cftr knockout intestine	9
High-energy pacing inhibits slow-wave dysrhythmias in the small intestine	9
miR-128 participates in the pathogenesis of chronic constipation by regulating the p38α/M-CSF inflammatory signaling pathway	9
Gut-heart axis: cardiac remodeling and heart failure in the context of inflammatory bowel disease and dysbiosis	9
Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders	9
Treg-specific IL-6R signaling: a novel role in the regulation of the intestinal epithelium	9
Deletion of H-ferritin in macrophages mitigates the development of steatohepatitis and hepatocellular carcinoma in mice	9
Lactiplantibacillus plantarum strengthens the intestinal barrier: involvement of the endocannabinoidome	8
A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts	8
Secretagogue-induced pancreatitis in mice devoid of chymotrypsin	8
SGLT2 inhibition leads to a restoration of hepatic and circulating metabolites involved in the folate cycle and pyrimidine biosynthesis	8
Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor	8
NMDA receptor expression during cell transformation process at early stages of liver cancer in rodent models	8
Choline-deficient, high-fat diet-induced MASH in Göttingen Minipigs: characterization and effects of a chow reversal period	8
Feeding mode influences dynamic gut microbiota signatures and affects susceptibility to anti-CD3 mAb-induced intestinal injury in neonatal mice	8
Adolescent binge drinking disrupts hepatic lipid homeostasis, leading to steatosis in rats: protective role of folic acid in cholesterol and fatty acid balance	8
A menu for microbes: unraveling appetite regulation and weight dynamics through the microbiota-brain connection across the lifespan	8
Gastrointestinal organoids in the study of viral infections	8
Maternal hepatocytes heterogeneously and dynamically exhibit developmental phenotypes partially via yes-associated protein 1 during pregnancy	8
Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner	8
Modeling the kinetics of interorgan arginine metabolism during bacterial sepsis in swine	8
Preclinical applications of high-definition manometry system to investigate pelvic floor muscle contribution to continence mechanisms in a rabbit model	8
Selective inhibition of hepatic stellate cell and fibroblast-derived LOXL1 attenuates BDL- and Mdr2^−/−-induced cholestatic liver fibrosis	8