OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Physiology-Gastrointestinal and Liver Physiology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Specific binding sites on Rhesus rotavirus capsid protein dictate the method of endocytosis inducing the murine model of biliary atresia	139
Lipidomic signatures discriminate subtle hepatic changes in the progression of porcine nonalcoholic steatohepatitis	64
Panaxynol improves crypt and mucosal architecture, suppresses colitis-enriched microbes, and alters the immune response to mitigate colitis	64
Effect of caloric intake and macronutrient composition on intestinal cholesterol absorption and bile acids in patients with obesity	56
Repurposing dried blood spot device technology to examine bile acid profiles in human dried fecal spot samples	50
Animal models with characteristics of irritable bowel syndrome with diarrhea: current applications and future perspectives	46
Functional involvement of the sternohyoid muscle during breathing and swallowing in rats	45
Rhamnogalacturonan promotes intestinal mucosal repair through increased cell migration	40
Regional and conditional variability of FXR: new lessons on ileal inflammation and gut barrier functions	37
Effects of potassium on laryngeal-induced swallowing rate in rats	37
Cells and mediators of inflammation as effectors of epithelial repair in the inflamed intestine	35
P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality	35
Mechanical stress-induced connective tissue growth factor plays a critical role in intestinal fibrosis in Crohn’s-like colitis	35
An inulin-type fructan CP-A from Codonopsis pilosula alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics	35
Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice	29
Defecation induced by stimulation of sacral S2 spinal root in cats	28
Gut feelings: the microbiota-gut-brain axis on steroids	28
NH₂-terminal deletion of specific phosphorylation sites on PHOX2B disrupts the formation of enteric neurons in vivo	27
A ganglionic intestinointestinal reflex activated by acute noxious challenge	26
Manganese efflux transporter SLC30A10 missense polymorphism T95I associated with liver injury retains manganese efflux activity	26
Angiotensin receptor blocker alleviates liver fibrosis by altering the mechanotransduction properties of hepatic stellate cells	25
Retraction for Wu et al., volume 294, 2008, p. G918–G927	25
Renalase peptides reduce pancreatitis severity in mice	24
Mechanisms underlying initiation of propulsion in guinea pig distal colon	24
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2	24

Mass cytometric analysis of circulating monocyte subsets in a murine model of diabetic gastroparesis	23
LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice	23
Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression	22
Contribution of sex hormones to the sexually dimorphic response of colorectal motility to noxious stimuli in rats	22
Coffee modulates insulin-hepatocyte nuclear factor-4α-Cyp7b1 pathway and reduces oxysterol-driven liver toxicity in a nonalcoholic fatty liver disease mouse model	22
Fluorescein clearance kinetics in blood and bile indicates hepatic ischemia-reperfusion injury in rats	21
Characterization of haustral activity in the human colon	21
Effect of ingesting a meal and orthostasis on the regulation of splanchnic and systemic hemodynamics and the responsiveness of cardiovascular α₁-adrenoceptors	21
Fructooligosaccharides slow colonic motility and activate myenteric neurons via calcium sensing and 5-HT₃ receptors in the proximal colon	20
FOXO3: at the crossroads of metabolic, inflammatory, and tumorigenic remodeling in the colon	20
Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study	20
Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms	20
Role of the microbiota-gut-brain axis in postacute COVID syndrome	19
Who’s talking to whom: microbiome-enteric nervous system interactions in early life	19
Myostatin in combination with creatine phosphokinase or albumin may differentiate patients with cirrhosis and sarcopenia	18
Are LRRK2 mysteries lurking in the gut?	18
Limosilactobacillus reuteri and Lacticaseibacillus rhamnosus GG differentially affect gut microbes and metabolites in mice with Treg deficiency	18
Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis	18
Novel 5-HT₇ receptor antagonists modulate intestinal immune responses and reduce severity of colitis	18
Is intestinal transport dysfunctional in COVID-19-related diarrhea?	18
A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure	17
The emerging roles of deep crypt secretory cells in colonic physiology	17
Blueberry anthocyanins improve liver fibrosis by regulating NCOA4 ubiquitination through TRIM7 to affect ferroptosis of hepatic stellate cells	17
Autophagy is required during high MUC2 mucin biosynthesis in colonic goblet cells to contend metabolic stress	17
Host-microbial interactions in the esophagus	17
Seladelpar combined with complementary therapies improves fibrosis, inflammation, and liver injury in a mouse model of nonalcoholic steatohepatitis	17
Tissue- and cell-specific properties of enterochromaffin cells affect the fate of tumorigenesis toward nonendocrine adenocarcinoma of the small intestine	16
Characterization of mitochondria-associated ER membranes in the enteric nervous system under physiological and pathological conditions	16
Single-cell analyses of human pancreas: characteristics of two populations of acinar cells in chronic pancreatitis	16
Initiation and severity of experimental pancreatitis are modified by phosphate	16
Ketamine and xylazine effects in murine model of acute pancreatitis	16
Gallbladder mucoceles in dogs: a novel form of acquired CFTR dysfunction causing localized cystic fibrosis-like disease	16
Obesogenic cafeteria diet induces dynamic changes in gut microbiota, reduces myenteric neuron excitability, and impairs gut contraction in mice	15
Subclinical necrotizing enterocolitis-induced systemic immune suppression in neonatal preterm pigs	15
Fecal microbiome and bile acid metabolome in adult short bowel syndrome	15
Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity	15
Intestinal ultrasound, an underutilized tool for assessing colonic motility	15
HOPX⁺ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia	15
Intestinal organoid coculture systems: current approaches, challenges, and future directions	14
ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis	14
Inhibited postprandial retrograde cyclic motor pattern in the distal colon of patients with diarrhea-predominant irritable bowel syndrome	14
Hepatic and intestinal tissue-specific Fxr deficiency alters bile acid homeostasis in female mice	14
Characterization of cytoplasmic lipid droplets in each region of the small intestine of lean and diet-induced obese mice in response to dietary fat	14
Gut neuropeptide involvement in Parkinson’s disease	14
Corrigendum for Ohno et al., volume 298, 2010, p. G63–G73.	14
Intrathecally administered substance P activated the spinal defecation center and enhanced colorectal motility in anesthetized rats	14
Dietary fat and low fiber in purified diets differently impact the gut-liver axis to promote obesity-linked metabolic impairments	13
Revisiting the gut-liver axis: gut lymphatic system in liver cirrhosis and portal hypertension	13
Short-term and long-term effects of unilateral external carotid artery ligation on orofacial functions in rats	12
Cholestenoic acid as endogenous epigenetic regulator decreases hepatocyte lipid accumulation in vitro and in vivo	12

A modular analysis of bile canalicular function and its implications for cholestasis	12
A simple and effective genotyping workflow for rapid detection of CRISPR genome editing	12
Local tissue response to a C-X-C motif chemokine ligand 12 therapy for fecal incontinence in a rabbit model	12
Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice	12
Formal degree programs in physiology promote careers of clinical scientists and benefit basic science departments	12
Optogenetic activation of the gut-brain axis in freely moving mice using a fully implantable wireless battery-free device	11
Hypoosmosis alters hepatocyte mitochondrial morphology and induces selective release of carbamoyl phosphate synthetase 1	11
Corrigendum for Liu et al., volume 305, 2013, p. G163–G171	11
Exploring the use of panaxynol from American ginseng to combat intestinal inflammation and colon cancer	11
Hope for the gut: new evidence suggests Western diet damage can be undone	11
Vitamin D deficiency enhances expression of autophagy-regulating miR-142-3p in mouse and “involved” IBD patient intestinal tissues	11
Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats	11
Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease	11
Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons	11
Multichannel magnetogastrogram: a clinical marker for pediatric chronic nausea	11
Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function	11
Dynamic functional luminal imaging probe analysis of the anal sphincter opening function during straining in healthy volunteers	11
Gut microbiota of patients insusceptible to olanzapine-induced fatty liver disease relieves hepatic steatosis in rats	11
β-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells	11
Deleterious impacts of Western diet on jejunum function and health are reversible	11
Examining enteric nervous system function in rat and mouse: an interspecies comparison of colonic motility	10
Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease	10
Targeting serotonin signaling in the gut to limit colitis via 5-HT₇ receptor antagonism	10
Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders	10
Preferential Neurogenesis of Nitrergic Neurons in the Myenteric Plexus of the DSS-induced Colitis Mouse Colon Causes Colonic Dysmotility in Colitis	10
Dynamics of the enterohepatic circulation of bile acids in healthy humans	10
Early-life fecal microbiome and metabolome dynamics in response to an intervention with infant formula containing specific prebiotics and postbiotics	10
Deacetylation of Notch1 by SIRT1 contributes to HBsAg- and HBeAg-mediated M2 macrophage polarization	10
miR-128 participates in the pathogenesis of chronic constipation by regulating the p38α/M-CSF inflammatory signaling pathway	10
High-energy pacing inhibits slow-wave dysrhythmias in the small intestine	10
Choline-deficient, high-fat diet-induced MASH in Göttingen Minipigs: characterization and effects of a chow reversal period	9
Secretagogue-induced pancreatitis in mice devoid of chymotrypsin	9
Saturated phosphatidic acids induce mTORC1-driven integrated stress response contributing to glucolipotoxicity in hepatocytes	9
Goblet cell hyperplasia is not epithelial-autonomous in the Cftr knockout intestine	9
Modeling the kinetics of interorgan arginine metabolism during bacterial sepsis in swine	9
Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner	9
Feeding mode influences dynamic gut microbiota signatures and affects susceptibility to anti-CD3 mAb-induced intestinal injury in neonatal mice	9
PPARα agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and β-catenin signaling	9
Gastrointestinal dysmotility in rodent models of Parkinson’s disease	9
Inhibition of hedgehog signaling ameliorates severity of chronic pancreatitis in experimental mouse models	9
A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts	9
Exfoliated epithelial cell transcriptome reflects both small and large intestinal cell signatures in piglets	9
Feeding intolerance after pediatric cardiac surgery is associated with dysbiosis, barrier dysfunction, and reduced short-chain fatty acids	9
Deletion of H-ferritin in macrophages mitigates the development of steatohepatitis and hepatocellular carcinoma in mice	9
Microbiota encroachment and a gut-adipose-liver axis in metabolic dysfunction-associated steatotic liver disease	9
Gut-Heart Axis: Cardiac Remodeling and Heart Failure in the Context of Inflammatory Bowel Disease and Dysbiosis	9
Selective inhibition of hepatic stellate cell and fibroblast-derived LOXL1 attenuates BDL- and Mdr2^−/−-induced cholestatic liver fibrosis	8
A functional interplay between the two BMP-SMAD pathway inhibitors TMPRSS6 and FKBP12 regulates hepcidin expression in vivo	8
Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal stomach	8
Duodenogastric reflux in health and disease: insights from a computational fluid dynamics model of the stomach	8
NMDA receptor expression during cell transformation process at early stages of liver cancer in rodent models	8
Contribution of monocarboxylate transporter 12 to blood supply of creatine on the sinusoidal membrane of the hepatocytes	8
Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage	8
A menu for microbes: unraveling appetite regulation and weight dynamics through the microbiota-brain connection across the lifespan	8
Maternal hepatocytes heterogeneously and dynamically exhibit developmental phenotypes partially via yes-associated protein 1 during pregnancy	8
SGLT2 inhibition leads to a restoration of hepatic and circulating metabolites involved in the folate cycle and pyrimidine biosynthesis	8
Could physical exercise improve mental health in the context of chronic liver disease?	8
Gastrointestinal organoids in the study of viral infections	8
Localized bioelectrical conduction block from radiofrequency gastric ablation persists after healing: safety and feasibility in a recovery model	8
Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease	8
Preclinical applications of high-definition manometry system to investigate pelvic floor muscle contribution to continence mechanisms in a rabbit model	8
Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor	8
Hypobaric hypoxia exposure impairs colonic goblet cell subpopulation via the HIF-1α signaling pathway	8
Electromechanical coupling and anatomy of the in vivo gastroduodenal junction	8
miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (SLC25A19) in pancreatic acinar cells	8