OOIR: Observatory of International Research

Papers

(The TQCC of Peptides is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Natriuretic peptides potentiate cardiac hypertrophic response to noradrenaline in rats	123
Corrigendum to “Oxytocin attenuates cardiac hypertrophy by improving cardiac glucose metabolism and regulating OXTR/JAK2/STAT3 axis” [Peptides 182 (2024) 171323]	84
The first structure-activity relationship study of oxytocin as a positive allosteric modulator for the µ opioid receptor	72
The present and future of synthetic orexin receptor agonists	67
Transcardiac gradients of pro-cholecystokinin, cholecystokinin, and gastrin in patients with and without heart failure with reduced ejection fraction	55
Editorial Board	49
Editorial Board	42
Minimum biological domain of xenin-25 required to induce anion secretion in the rat ileum	41
PCP consensus protein/peptide alphavirus antigens stimulate broad spectrum neutralizing antibodies	37
Gut hormone analogues and skeletal health in diabetes and obesity: Evidence from preclinical models	35
Serum alanine transaminase is predictive of fasting and postprandial insulin and glucagon concentrations in type 2 diabetes	34
Desacyl-ghrelin, not just an inactive form of ghrelin? A review of current knowledge on the biological actions of desacyl-ghrelin	34
KNDy neurons as the GnRH pulse generator: Recent studies in ruminants	33
Emerging roles of oxyntomodulin-based glucagon-like peptide-1/glucagon co-agonist analogs in diabetes and obesity	31
Angiotensin-(1−7), a protective peptide against vascular aging	28
Editorial Board	27
Potential of plant-derived peptides for the improvement of memory and cognitive function	26
Peptides and primate personality: Central and peripheral oxytocin and vasopressin levels and social behavior in two baboon species (Papio hamadryas and Papio anubis)	26
Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development	25
Asprosin-mediated regulation of ovarian functions in mice: An age-dependent study	23
The antimicrobial peptide Abaecin alleviates colitis in mice by regulating inflammatory signaling pathways and intestinal microbial composition	23
Editorial Board	23
The impact of multifunctional enkephalin analogs and morphine on the protein changes in crude membrane fractions isolated from the rat brain cortex and hippocampus	23
The effect of acute exercise on pre-prandial ghrelin levels in healthy adults: A systematic review and meta-analysis	22
Effect of Fc-Elabela-21 on renal ischemia/reperfusion injury in mice: Mediation of anti-apoptotic effect via Akt phosphorylation	22

Studies on the in vitro mechanism and in vivo therapeutic effect of the antimicrobial peptide ACP5 against Trichophyton mentagrophytes	22
Nesfatin-1 regulates steroidogenesis in mouse Leydig cells	22
Calcitonin gene-related peptide exerts inhibitory effects on autophagy in the heart of mice	21
Synthesis, conformation and cytotoxic activity of short hybrid peptides containing conformationally constrained 1-(aminomethyl)cyclohexanecarboxylic acid and gabapentin	21
Dulaglutide accelerates diabetic wound healing by suppressing Nrf2-dependent ferroptosis in diabetic mice	20
VR-10 polypeptide interacts with CD36 to induce cell apoptosis and autophagy in choroid-retinal endothelial cells: Identification of VR-10 as putative novel therapeutic agent for choroid neovasculariz	19
GIP-derived GIP receptor antagonists – a review of their role in GIP receptor pharmacology	18
Lasso peptides realm: Insights and applications	18
Glucagon-like peptide-1 receptor promotes osteoblast differentiation of dental pulp stem cells and bone formation in a zebrafish scale regeneration model	18
Modulatory role of neuropeptide FF system in macrophages	18
Dysfunction of the renin-angiotensin-aldosterone system in human septic shock	18
Editorial Board	17
Inhibitors of the MAPK/ NF-κB pathway attenuate the upregulation of the ETB receptor mediated by high glucose in vascular smooth muscle cells	17
Suppression of B-type natriuretic peptide gene expression in cardiomyocytes under anoxic conditions	17
Special issue on Invertebrate Peptides	16
A novel endomorphin-2/salmon calcitonin hybrid peptide with enhancing anti-allodynic and anti-anxiety effects	16
Jan Fahrenkrug (6/6 1947 – 10/11 2021)	16
The intricate relationship between circadian rhythms and gastrointestinal peptides in obesity	16
Simplified drug efficacy evaluation system for vasopressin neurodegenerative disease using mouse disease-specific induced pluripotent stem cells	16
Significance of D- tryptophan in Contryphan-Ar1131 Conus peptide: Oxidative folding, trypsin binding, and photostabilization activity	16
Allatotropin (AT) related peptides L-ATRP and D2-ATRP diastereomers activate an endogenous receptor and suppress heart rate in the Pacific abalone Haliotis discus hannai	16
Editorial Board	15
Ghrelin ameliorates cardiac fibrosis after myocardial infarction by regulating the Nrf2/NADPH/ROS pathway	15
Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity	15
Peptides as mediators of stress responses	15
The T-1 conotoxin μ-SrVA from the worm hunting marine snail Conus spurius preferentially blocks the human NaV1.5 channel	15
Editorial Board	15
Endogenous opiates and behavior: 2023	15
The role of leptin and ghrelin in the regulation of appetite in obesity	15
JHP-7 (QLLEELKR), a heptapeptide derived from Jinhua ham, may ameliorate intrauterine adhesion (IUA) via inhibiting inflammatory response and apoptosis	15
Development of a glucagon sensitivity test in humans: Pilot data and the GLUSENTIC study protocol	15
Glucagon and energy expenditure; Revisiting amino acid metabolism and implications for weight loss therapy	15
Venomous gland transcriptome and venom proteomic analysis of the scorpion Androctonus amoreuxi reveal new peptides with anti-SARS-CoV-2 activity	15
Investigation of irisin's role in pubertal onset physiology in female rats	14
Reduced plasma cortistatin is related to clinical parameters in patients with essential hypertension	14
Glucagon-based therapy for people with diabetes and obesity: What is the sweet spot?	14
Targeting the GLP-2 receptor in the management of obesity	14
Mendelian randomization study of the relation between adiponectin and heart function, unravelling the paradox	13
The effects of corticotropin-releasing factor (CRF) and urocortins on the noradrenaline (NA) released from the locus coeruleus (LC)	13
Corrigendum to “Liraglutide inhibited AGEs induced coronary smooth muscle cell phenotypic transition through inhibiting the NF-κB signal pathway” [Peptides 112 (2019) 125–132]	13
Role of brain NUCB2/nesfatin-1 in stress and stress-related gastrointestinal disorders	12
An improved sample extraction method reveals that plasma receptor for advanced glycation end-products (RAGE) modulates circulating free oxytocin in mice	12
Spexin expression in the human bile duct and perihilar cholangiocarcinoma	12
Body weight modulates the impact of oxytocin on chronic cold-immobilization stress response	12
Editorial: Special issue novel aspects of islet peptides	12
The apelin-apela receptor APJ is necessary for formation and healing of ischemia reperfusion-induced gastric ulcer in rats	12
Effect of pregnancy on the expression of nutrient-sensors and satiety hormones in mice	12
GLP-1 and GIP receptor signaling in beta cells – A review of receptor interactions and co-stimulation	12
Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity	12
Estrogens impair hypophagia and hypothalamic cell activation induced by vasoactive intestinal peptide, but not by pituitary adenylate cyclase-activating polypeptide	12

Differential expression of motilin receptors on the endothelium of dog gastrointestinal arteries and motilin-induced motilin receptor dependent relaxation of corresponding arteries	12
Alamandine, a derivative of angiotensin-(1-7), alleviates sepsis-associated renal inflammation and apoptosis by inhibiting the PI3K/Ak and MAPK pathways	12
Effectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats	12
The non-cardiovascular actions of ACE	12
The brain oxytocin and corticotropin-releasing factor systems in grieving mothers: What we know and what we need to learn	11
Synergistic interaction between DAMGO-NH2 and NOP01 in peripherally acting antinociception in two mouse models of formalin pain	11
Alamandine attenuates oxidative stress in the right carotid following transverse aortic constriction in mice	11
Corticotropin-releasing factor receptor 1 (CRF-R1) antagonists: Promising agents to prevent visceral hypersensitivity in irritable bowel syndrome	11
Angiotensin-(1−7) attenuates the negative inotropic response to acetylcholine in the heart	11
Editorial Board	11
Egg white-derived peptide KPHAEVVLR promotes wound healing in rat palatal mucosa via PI3K/AKT/mTOR pathway	11
Irisin alleviates hyperoxia-induced bronchopulmonary dysplasia through activation of Nrf2/HO-1 pathway	11
Neuropeptides affecting social behavior in mammals: Oxytocin	11
A short framework-III (mini-M-2) conotoxin from the venom of a vermivorous species, Conus archon, inhibits human neuronal nicotinic acetylcholine receptors	10
Characterization of rice endosperm-derived antidepressant-like peptide (REAP): An orally active novel tridecapeptide derived from rice protein	10
Editorial Board	10
Angiotensin-(1-7) reduces doxorubicin-induced aortic arch dysfunction in male and female juvenile Sprague Dawley rats through pleiotropic mechanisms	10
Irisin prevents hypoxic-ischemic brain damage in rats by inhibiting oxidative stress and protecting the blood-brain barrier	10
CCHamide2-receptor regulates feeding behavior in the pea aphid, Acyrthosiphon pisum	10
Alarin moderated myocardial hypertrophy via inhibiting cyclic adenosine monophosphate/protein kinase A signaling pathway to attenuate autophagy	10
Role of sexually dimorphic oxytocin receptor-expressing neurons in the anteroventral periventricular nucleus on maternal behavior	10
Editorial Board	10
AT2 receptor agonist LP2 restores respiratory function in a rat model of bleomycin-induced lung remodelling	10
Structure and function of neurohypophysial hormones	10
Interleukin-6, undercarboxylated osteocalcin, and brain-derived neurotrophic factor responses to single and repeated sessions of high-intensity interval exercise	10
Nesfatin-1 is involved in hyperbaric oxygen-mediated therapeutic effects in high fat diet-induced hyperphagia in mice	10
Semaglutide early intervention attenuated testicular dysfunction by targeting the GLP-1–PPAR-α–Kisspeptin–Steroidogenesis signaling pathway in a testicular ischemia-reperfusion rat model	10
In memoriam: Dr. Stephen Tobe (11 October 1944 – 31 December 2020)	10
Recent articles highlighting the multifunctional character and wider therapeutic potential of antimicrobial peptides	10
GLP-1 receptor agonism and GIP receptor antagonism induce substantial alterations in enteroendocrine and islet cell populations in obese high fat fed mice	10
Engineering a potent and long-acting GLP-1/Y2 receptor dual agonist as a multi-agonist therapy for diabetes and obesity	10
Host defense peptides at the crossroad of endothelial cell physiology: Insight into mechanistic and pharmacological implications	9
PD1 CD44 antiviral peptide as an inhibitor of the protein-protein interaction in dengue virus invasion	9
The impact of GLP-1 signalling on the energy metabolism of pancreatic islet β-cells and extrapancreatic tissues	9
Heart peptides and HFpEF (heart failure with preserved ejection fraction)	9
Development of antimicrobial peptides as a strategy for infectious disease control	9
Discovery of the bioactive form of glucagon-like peptide-1: An attempt to correct some misconceptions	9
LP2, a cyclic angiotensin-(1−7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice	9
Functional role of immunoglobulin G as an oxytocin-carrier protein	9
Adropin: A cardio-metabolic hormone in the periphery, a neurohormone in the brain?	9
Abba J. Kastin – Tribute to the founding and honorary editor of PEPTIDES	9
Urotensin II induces activation of NLRP3 and pyroptosis through calcineurin in cardiomyocytes	9
Involvement of relaxin-family peptide-3 receptor (RXFP3) in the ventral dentate gyrus of the hippocampus in spatial and fear memory in rats	9
The proline-rich myticalins from Mytilus galloprovincialis display a membrane-permeabilizing antimicrobial mode of action	9
History of peptide research: Ulf Svante von Euler's last visit to Yugoslavia	8
Antiosteoporosis effects of a marine antimicrobial peptide pardaxin via regulation of the osteogenesis pathway	8
Modulatory role of PACAP and VIP on HIFs expression in lung adenocarcinoma	8
Evaluation of plasma arginine vasopressin during hypertonic saline loading: A comparison of radioimmunoassay and liquid chromatography–tandem mass spectrometry	8
Neprilysin deficiency reduces hepatic gluconeogenesis in high fat-fed mice	8
Peptides in the regulation of glucagon secretion	8
Isolation and characterization of FMRFamide-like peptides in the venoms of solitary sphecid wasps	8
Publishing in PEPTIDES − A 2022 update	8
Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives	8
Acute effects of peripherally administered nicotine on food intake via the central anorectic peptide nesfatin-1/nucleobindin-2 in adult male rats	8
Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway	8
Diminazene Aceturate, an angiotensin converting enzyme 2 (ACE2) activator, promotes cardioprotection in ischemia/reperfusion-induced cardiac injury	8
Synthesis and characterization of piperic acid conjugates with homochiral and heterochiral dipeptides containing phenylalanine and their application in skin cancer	8
Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals	8
A murine model of obesity with hyperinsulinemia and hepatic steatosis involving neurosecretory protein GL gene and a low-fat/medium-sucrose diet	8
Participation of angiotensin-(1-7) in exercise-induced analgesia in rats with neuropathic pain	8
Amphibian host-defense peptides with potential for Type 2 diabetes therapy – an updated review	8
Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects	8
Optogenetics studies of kisspeptin neurons	8
The regulatory role of central neuropeptide-S in locomotion	8