OOIR: Observatory of International Research

Papers

(The TQCC of Peptides is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Natriuretic peptides potentiate cardiac hypertrophic response to noradrenaline in rats	125
Corrigendum to “Oxytocin attenuates cardiac hypertrophy by improving cardiac glucose metabolism and regulating OXTR/JAK2/STAT3 axis” [Peptides 182 (2024) 171323]	89
The first structure-activity relationship study of oxytocin as a positive allosteric modulator for the µ opioid receptor	73
Transcardiac gradients of pro-cholecystokinin, cholecystokinin, and gastrin in patients with and without heart failure with reduced ejection fraction	71
Editorial Board	58
Editorial Board	51
Gut hormone analogues and skeletal health in diabetes and obesity: Evidence from preclinical models	37
Emerging roles of oxyntomodulin-based glucagon-like peptide-1/glucagon co-agonist analogs in diabetes and obesity	34
Minimum biological domain of xenin-25 required to induce anion secretion in the rat ileum	34
KNDy neurons as the GnRH pulse generator: Recent studies in ruminants	33
Desacyl-ghrelin, not just an inactive form of ghrelin? A review of current knowledge on the biological actions of desacyl-ghrelin	31
Serum alanine transaminase is predictive of fasting and postprandial insulin and glucagon concentrations in type 2 diabetes	28
The present and future of synthetic orexin receptor agonists	27
Angiotensin-(1−7), a protective peptide against vascular aging	26
Editorial Board	25
Peptides and primate personality: Central and peripheral oxytocin and vasopressin levels and social behavior in two baboon species (Papio hamadryas and Papio anubis)	25
PCP consensus protein/peptide alphavirus antigens stimulate broad spectrum neutralizing antibodies	25
Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development	23
Asprosin-mediated regulation of ovarian functions in mice: An age-dependent study	23
The effect of acute exercise on pre-prandial ghrelin levels in healthy adults: A systematic review and meta-analysis	22
Studies on the in vitro mechanism and in vivo therapeutic effect of the antimicrobial peptide ACP5 against Trichophyton mentagrophytes	21
The antimicrobial peptide Abaecin alleviates colitis in mice by regulating inflammatory signaling pathways and intestinal microbial composition	19
The impact of multifunctional enkephalin analogs and morphine on the protein changes in crude membrane fractions isolated from the rat brain cortex and hippocampus	19
Effect of Fc-Elabela-21 on renal ischemia/reperfusion injury in mice: Mediation of anti-apoptotic effect via Akt phosphorylation	19
Editorial Board	19

Synthesis, conformation and cytotoxic activity of short hybrid peptides containing conformationally constrained 1-(aminomethyl)cyclohexanecarboxylic acid and gabapentin	18
Calcitonin gene-related peptide exerts inhibitory effects on autophagy in the heart of mice	18
Nesfatin-1 regulates steroidogenesis in mouse Leydig cells	18
Suppression of B-type natriuretic peptide gene expression in cardiomyocytes under anoxic conditions	18
Glucagon-like peptide-1 receptor promotes osteoblast differentiation of dental pulp stem cells and bone formation in a zebrafish scale regeneration model	17
Dulaglutide accelerates diabetic wound healing by suppressing Nrf2-dependent ferroptosis in diabetic mice	17
Lasso peptides realm: Insights and applications	17
VR-10 polypeptide interacts with CD36 to induce cell apoptosis and autophagy in choroid-retinal endothelial cells: Identification of VR-10 as putative novel therapeutic agent for choroid neovasculariz	17
GIP-derived GIP receptor antagonists – a review of their role in GIP receptor pharmacology	17
Inhibitors of the MAPK/ NF-κB pathway attenuate the upregulation of the ETB receptor mediated by high glucose in vascular smooth muscle cells	16
Dysfunction of the renin-angiotensin-aldosterone system in human septic shock	16
Impact of galanin receptors 2 and 3 double-knockout on neuroinflammation and functional recovery following traumatic brain injury	16
Modulatory role of neuropeptide FF system in macrophages	16
Endogenous opiates and behavior: 2024	16
Editorial Board	15
Jan Fahrenkrug (6/6 1947 – 10/11 2021)	15
Endogenous opiates and behavior: 2023	15
Simplified drug efficacy evaluation system for vasopressin neurodegenerative disease using mouse disease-specific induced pluripotent stem cells	15
Significance of D- tryptophan in Contryphan-Ar1131 Conus peptide: Oxidative folding, trypsin binding, and photostabilization activity	15
JHP-7 (QLLEELKR), a heptapeptide derived from Jinhua ham, may ameliorate intrauterine adhesion (IUA) via inhibiting inflammatory response and apoptosis	15
A novel endomorphin-2/salmon calcitonin hybrid peptide with enhancing anti-allodynic and anti-anxiety effects	15
Special issue on Invertebrate Peptides	15
Glucagon and energy expenditure; Revisiting amino acid metabolism and implications for weight loss therapy	15
Allatotropin (AT) related peptides L-ATRP and D2-ATRP diastereomers activate an endogenous receptor and suppress heart rate in the Pacific abalone Haliotis discus hannai	15
Recombinant production of isotope-labeled human α-defensin 5 via calmodulin fusion and insights into its expression enhancement	14
Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity	14
The intricate relationship between circadian rhythms and gastrointestinal peptides in obesity	14
Editorial Board	13
The role of leptin and ghrelin in the regulation of appetite in obesity	13
The T-1 conotoxin μ-SrVA from the worm hunting marine snail Conus spurius preferentially blocks the human NaV1.5 channel	13
Peptides as mediators of stress responses	13
Editorial Board	13
Venomous gland transcriptome and venom proteomic analysis of the scorpion Androctonus amoreuxi reveal new peptides with anti-SARS-CoV-2 activity	13
Development of a glucagon sensitivity test in humans: Pilot data and the GLUSENTIC study protocol	12
Investigation of irisin's role in pubertal onset physiology in female rats	12
Estrogens impair hypophagia and hypothalamic cell activation induced by vasoactive intestinal peptide, but not by pituitary adenylate cyclase-activating polypeptide	12
The effects of corticotropin-releasing factor (CRF) and urocortins on the noradrenaline (NA) released from the locus coeruleus (LC)	12
Ghrelin ameliorates cardiac fibrosis after myocardial infarction by regulating the Nrf2/NADPH/ROS pathway	12
Targeting the GLP-2 receptor in the management of obesity	12
Editorial: Special issue novel aspects of islet peptides	12
Corrigendum to “Liraglutide inhibited AGEs induced coronary smooth muscle cell phenotypic transition through inhibiting the NF-κB signal pathway” [Peptides 112 (2019) 125–132]	12
Reduced plasma cortistatin is related to clinical parameters in patients with essential hypertension	12
Mendelian randomization study of the relation between adiponectin and heart function, unravelling the paradox	12
PACAP inhibits sepsis-associated acute lung injury by inhibiting the Sp1/AQP1 pathway	12
Glucagon-based therapy for people with diabetes and obesity: What is the sweet spot?	12
The apelin-apela receptor APJ is necessary for formation and healing of ischemia reperfusion-induced gastric ulcer in rats	11
Effectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats	11
The non-cardiovascular actions of ACE	11
Differential expression of motilin receptors on the endothelium of dog gastrointestinal arteries and motilin-induced motilin receptor dependent relaxation of corresponding arteries	11
Effect of pregnancy on the expression of nutrient-sensors and satiety hormones in mice	11

Role of brain NUCB2/nesfatin-1 in stress and stress-related gastrointestinal disorders	11
An improved sample extraction method reveals that plasma receptor for advanced glycation end-products (RAGE) modulates circulating free oxytocin in mice	11
Egg white-derived peptide KPHAEVVLR promotes wound healing in rat palatal mucosa via PI3K/AKT/mTOR pathway	11
Role of sexually dimorphic oxytocin receptor-expressing neurons in the anteroventral periventricular nucleus on maternal behavior	10
Body weight modulates the impact of oxytocin on chronic cold-immobilization stress response	10
Editorial Board	10
GLP-1 and GIP receptor signaling in beta cells – A review of receptor interactions and co-stimulation	10
Neuropeptides affecting social behavior in mammals: Oxytocin	10
Characterization of rice endosperm-derived antidepressant-like peptide (REAP): An orally active novel tridecapeptide derived from rice protein	10
Corticotropin-releasing factor receptor 1 (CRF-R1) antagonists: Promising agents to prevent visceral hypersensitivity in irritable bowel syndrome	10
Alamandine, a derivative of angiotensin-(1-7), alleviates sepsis-associated renal inflammation and apoptosis by inhibiting the PI3K/Ak and MAPK pathways	10
In memoriam: Dr. Stephen Tobe (11 October 1944 – 31 December 2020)	10
Editorial Board	10
The brain oxytocin and corticotropin-releasing factor systems in grieving mothers: What we know and what we need to learn	10
Synergistic interaction between DAMGO-NH2 and NOP01 in peripherally acting antinociception in two mouse models of formalin pain	10
Angiotensin-(1−7) attenuates the negative inotropic response to acetylcholine in the heart	10
Semaglutide early intervention attenuated testicular dysfunction by targeting the GLP-1–PPAR-α–Kisspeptin–Steroidogenesis signaling pathway in a testicular ischemia-reperfusion rat model	10
Recent articles highlighting the multifunctional character and wider therapeutic potential of antimicrobial peptides	10
Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity	10
Editorial Board	10
Spexin expression in the human bile duct and perihilar cholangiocarcinoma	10
Irisin alleviates hyperoxia-induced bronchopulmonary dysplasia through activation of Nrf2/HO-1 pathway	10
Alamandine attenuates oxidative stress in the right carotid following transverse aortic constriction in mice	10
Interleukin-6, undercarboxylated osteocalcin, and brain-derived neurotrophic factor responses to single and repeated sessions of high-intensity interval exercise	9
CCHamide2-receptor regulates feeding behavior in the pea aphid, Acyrthosiphon pisum	9
Nesfatin-1 is involved in hyperbaric oxygen-mediated therapeutic effects in high fat diet-induced hyperphagia in mice	9
Host defense peptides at the crossroad of endothelial cell physiology: Insight into mechanistic and pharmacological implications	9
The proline-rich myticalins from Mytilus galloprovincialis display a membrane-permeabilizing antimicrobial mode of action	9
GLP-1 receptor agonism and GIP receptor antagonism induce substantial alterations in enteroendocrine and islet cell populations in obese high fat fed mice	9
Structure and function of neurohypophysial hormones	9
Angiotensin-(1-7) reduces doxorubicin-induced aortic arch dysfunction in male and female juvenile Sprague Dawley rats through pleiotropic mechanisms	9
Development of antimicrobial peptides as a strategy for infectious disease control	9
Discovery of the bioactive form of glucagon-like peptide-1: An attempt to correct some misconceptions	9
LP2, a cyclic angiotensin-(1−7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice	9
AT2 receptor agonist LP2 restores respiratory function in a rat model of bleomycin-induced lung remodelling	9
Engineering a potent and long-acting GLP-1/Y2 receptor dual agonist as a multi-agonist therapy for diabetes and obesity	9
Irisin prevents hypoxic-ischemic brain damage in rats by inhibiting oxidative stress and protecting the blood-brain barrier	9
Abba J. Kastin – Tribute to the founding and honorary editor of PEPTIDES	9
Urotensin II induces activation of NLRP3 and pyroptosis through calcineurin in cardiomyocytes	9
Alarin moderated myocardial hypertrophy via inhibiting cyclic adenosine monophosphate/protein kinase A signaling pathway to attenuate autophagy	9
Heart peptides and HFpEF (heart failure with preserved ejection fraction)	8
Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway	8
Acute effects of peripherally administered nicotine on food intake via the central anorectic peptide nesfatin-1/nucleobindin-2 in adult male rats	8
Diminazene Aceturate, an angiotensin converting enzyme 2 (ACE2) activator, promotes cardioprotection in ischemia/reperfusion-induced cardiac injury	8
The impact of GLP-1 signalling on the energy metabolism of pancreatic islet β-cells and extrapancreatic tissues	8
PD1 CD44 antiviral peptide as an inhibitor of the protein-protein interaction in dengue virus invasion	8
Evaluation of plasma arginine vasopressin during hypertonic saline loading: A comparison of radioimmunoassay and liquid chromatography–tandem mass spectrometry	8
Optogenetics studies of kisspeptin neurons	8
Modulatory role of PACAP and VIP on HIFs expression in lung adenocarcinoma	8
Functional role of immunoglobulin G as an oxytocin-carrier protein	8
A short framework-III (mini-M-2) conotoxin from the venom of a vermivorous species, Conus archon, inhibits human neuronal nicotinic acetylcholine receptors	8
Amphibian host-defense peptides with potential for Type 2 diabetes therapy – an updated review	8
Neprilysin deficiency reduces hepatic gluconeogenesis in high fat-fed mice	8
Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects	8
Involvement of relaxin-family peptide-3 receptor (RXFP3) in the ventral dentate gyrus of the hippocampus in spatial and fear memory in rats	8