OOIR: Observatory of International Research

Papers

(The TQCC of Peptides is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Angiotensin-(1−7), a protective peptide against vascular aging	114
PCP consensus protein/peptide alphavirus antigens stimulate broad spectrum neutralizing antibodies	73
Orexin (hypocretin) participates in central autonomic regulation during fight-or-flight response	69
The first structure-activity relationship study of oxytocin as a positive allosteric modulator for the µ opioid receptor	66
Natriuretic peptides potentiate cardiac hypertrophic response to noradrenaline in rats	50
Serum alanine transaminase is predictive of fasting and postprandial insulin and glucagon concentrations in type 2 diabetes	48
Corrigendum to “Oxytocin attenuates cardiac hypertrophy by improving cardiac glucose metabolism and regulating OXTR/JAK2/STAT3 axis” [Peptides 182 (2024) 171323]	44
Transcardiac gradients of pro-cholecystokinin, cholecystokinin, and gastrin in patients with and without heart failure with reduced ejection fraction	39
Emerging roles of oxyntomodulin-based glucagon-like peptide-1/glucagon co-agonist analogs in diabetes and obesity	34
Editorial Board	34
KNDy neurons as the GnRH pulse generator: Recent studies in ruminants	31
Editorial Board	31
LC–MS/MS measurement of endogenous oxytocin in the posterior pituitary and CSF of macaques: A pilot study	30
Minimum biological domain of xenin-25 required to induce anion secretion in the rat ileum	29
The present and future of synthetic orexin receptor agonists	26
Desacyl-ghrelin, not just an inactive form of ghrelin? A review of current knowledge on the biological actions of desacyl-ghrelin	25
Gut hormone analogues and skeletal health in diabetes and obesity: Evidence from preclinical models	24
Editorial Board	24
Peptides and primate personality: Central and peripheral oxytocin and vasopressin levels and social behavior in two baboon species (Papio hamadryas and Papio anubis)	22
Studies on the in vitro mechanism and in vivo therapeutic effect of the antimicrobial peptide ACP5 against Trichophyton mentagrophytes	22
The impact of multifunctional enkephalin analogs and morphine on the protein changes in crude membrane fractions isolated from the rat brain cortex and hippocampus	22
Asprosin-mediated regulation of ovarian functions in mice: An age-dependent study	21
The antimicrobial peptide Abaecin alleviates colitis in mice by regulating inflammatory signaling pathways and intestinal microbial composition	21
Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development	20
Editorial Board	20

Effect of Fc-Elabela-21 on renal ischemia/reperfusion injury in mice: Mediation of anti-apoptotic effect via Akt phosphorylation	20
Lasso peptides realm: Insights and applications	19
The effect of acute exercise on pre-prandial ghrelin levels in healthy adults: A systematic review and meta-analysis	19
Calcitonin gene-related peptide exerts inhibitory effects on autophagy in the heart of mice	19
Glucagon-like peptide-1 receptor promotes osteoblast differentiation of dental pulp stem cells and bone formation in a zebrafish scale regeneration model	19
Nesfatin-1 regulates steroidogenesis in mouse Leydig cells	19
Suppression of B-type natriuretic peptide gene expression in cardiomyocytes under anoxic conditions	19
Potential of plant-derived peptides for the improvement of memory and cognitive function	19
Dulaglutide accelerates diabetic wound healing by suppressing Nrf2-dependent ferroptosis in diabetic mice	18
Modulatory role of neuropeptide FF system in macrophages	18
Synthesis, conformation and cytotoxic activity of short hybrid peptides containing conformationally constrained 1-(aminomethyl)cyclohexanecarboxylic acid and gabapentin	18
Dysfunction of the renin-angiotensin-aldosterone system in human septic shock	18
VR-10 polypeptide interacts with CD36 to induce cell apoptosis and autophagy in choroid-retinal endothelial cells: Identification of VR-10 as putative novel therapeutic agent for choroid neovasculariz	17
Editorial Board	17
GIP-derived GIP receptor antagonists – a review of their role in GIP receptor pharmacology	17
Editorial Board	16
Special issue on Invertebrate Peptides	16
Inhibitors of the MAPK/ NF-κB pathway attenuate the upregulation of the ETB receptor mediated by high glucose in vascular smooth muscle cells	16
Simplified drug efficacy evaluation system for vasopressin neurodegenerative disease using mouse disease-specific induced pluripotent stem cells	16
Jan Fahrenkrug (6/6 1947 – 10/11 2021)	15
Significance of D- tryptophan in Contryphan-Ar1131 Conus peptide: Oxidative folding, trypsin binding, and photostabilization activity	15
Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice	14
Allatotropin (AT) related peptides L-ATRP and D2-ATRP diastereomers activate an endogenous receptor and suppress heart rate in the Pacific abalone Haliotis discus hannai	14
Endogenous opiates and behavior: 2023	14
Post-translationally modified conopeptides: Biological activities and pharmacological applications	14
Glucagon and energy expenditure; Revisiting amino acid metabolism and implications for weight loss therapy	14
A novel endomorphin-2/salmon calcitonin hybrid peptide with enhancing anti-allodynic and anti-anxiety effects	14
The intricate relationship between circadian rhythms and gastrointestinal peptides in obesity	14
The role of leptin and ghrelin in the regulation of appetite in obesity	14
Peptides as mediators of stress responses	13
Editorial Board	13
Investigation of irisin's role in pubertal onset physiology in female rats	13
Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity	13
Editorial Board	13
Reduced plasma cortistatin is related to clinical parameters in patients with essential hypertension	13
Mendelian randomization study of the relation between adiponectin and heart function, unravelling the paradox	13
Venomous gland transcriptome and venom proteomic analysis of the scorpion Androctonus amoreuxi reveal new peptides with anti-SARS-CoV-2 activity	13
The T-1 conotoxin μ-SrVA from the worm hunting marine snail Conus spurius preferentially blocks the human NaV1.5 channel	13
Glucagon-based therapy for people with diabetes and obesity: What is the sweet spot?	13
Development of a glucagon sensitivity test in humans: Pilot data and the GLUSENTIC study protocol	13
Targeting the GLP-2 receptor in the management of obesity	12
Alamandine, a derivative of angiotensin-(1-7), alleviates sepsis-associated renal inflammation and apoptosis by inhibiting the PI3K/Ak and MAPK pathways	12
The effects of corticotropin-releasing factor (CRF) and urocortins on the noradrenaline (NA) released from the locus coeruleus (LC)	12
Editorial: Special issue novel aspects of islet peptides	12
Ghrelin ameliorates cardiac fibrosis after myocardial infarction by regulating the Nrf2/NADPH/ROS pathway	12
Corrigendum to “Liraglutide inhibited AGEs induced coronary smooth muscle cell phenotypic transition through inhibiting the NF-κB signal pathway” [Peptides 112 (2019) 125–132]	12
Effectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats	12
Estrogens impair hypophagia and hypothalamic cell activation induced by vasoactive intestinal peptide, but not by pituitary adenylate cyclase-activating polypeptide	11
The apelin-apela receptor APJ is necessary for formation and healing of ischemia reperfusion-induced gastric ulcer in rats	11
Differential expression of motilin receptors on the endothelium of dog gastrointestinal arteries and motilin-induced motilin receptor dependent relaxation of corresponding arteries	11

Role of brain NUCB2/nesfatin-1 in stress and stress-related gastrointestinal disorders	11
The non-cardiovascular actions of ACE	11
Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity	11
Body weight modulates the impact of oxytocin on chronic cold-immobilization stress response	11
An improved sample extraction method reveals that plasma receptor for advanced glycation end-products (RAGE) modulates circulating free oxytocin in mice	11
Egg white-derived peptide KPHAEVVLR promotes wound healing in rat palatal mucosa via PI3K/AKT/mTOR pathway	10
Corticotropin-releasing factor receptor 1 (CRF-R1) antagonists: Promising agents to prevent visceral hypersensitivity in irritable bowel syndrome	10
Engineering a potent and long-acting GLP-1/Y2 receptor dual agonist as a multi-agonist therapy for diabetes and obesity	10
Irisin alleviates hyperoxia-induced bronchopulmonary dysplasia through activation of Nrf2/HO-1 pathway	10
Editorial Board	10
Neuropeptides affecting social behavior in mammals: Oxytocin	10
Characterization of rice endosperm-derived antidepressant-like peptide (REAP): An orally active novel tridecapeptide derived from rice protein	10
GLP-1 and GIP receptor signaling in beta cells – A review of receptor interactions and co-stimulation	10
Structure and function of neurohypophysial hormones	10
FxRIamide regulates the oscillatory activity in the olfactory center of the terrestrial slug Limax	10
Interleukin-6, undercarboxylated osteocalcin, and brain-derived neurotrophic factor responses to single and repeated sessions of high-intensity interval exercise	10
Editorial Board	10
Editorial Board	10
Angiotensin-(1−7) attenuates the negative inotropic response to acetylcholine in the heart	10
Semaglutide early intervention attenuated testicular dysfunction by targeting the GLP-1–PPAR-α–Kisspeptin–Steroidogenesis signaling pathway in a testicular ischemia-reperfusion rat model	10
Effect of pregnancy on the expression of nutrient-sensors and satiety hormones in mice	10
Role of sexually dimorphic oxytocin receptor-expressing neurons in the anteroventral periventricular nucleus on maternal behavior	10
Alamandine attenuates oxidative stress in the right carotid following transverse aortic constriction in mice	10
In memoriam: Dr. Stephen Tobe (11 October 1944 – 31 December 2020)	10
The brain oxytocin and corticotropin-releasing factor systems in grieving mothers: What we know and what we need to learn	10
Synergistic interaction between DAMGO-NH2 and NOP01 in peripherally acting antinociception in two mouse models of formalin pain	10
Recent articles highlighting the multifunctional character and wider therapeutic potential of antimicrobial peptides	10
Development of antimicrobial peptides as a strategy for infectious disease control	9
GLP-1 receptor agonism and GIP receptor antagonism induce substantial alterations in enteroendocrine and islet cell populations in obese high fat fed mice	9
Irisin prevents hypoxic-ischemic brain damage in rats by inhibiting oxidative stress and protecting the blood-brain barrier	9
Urotensin II induces activation of NLRP3 and pyroptosis through calcineurin in cardiomyocytes	9
Abba J. Kastin – Tribute to the founding and honorary editor of PEPTIDES	9
CCHamide2-receptor regulates feeding behavior in the pea aphid, Acyrthosiphon pisum	9
Nesfatin-1 is involved in hyperbaric oxygen-mediated therapeutic effects in high fat diet-induced hyperphagia in mice	9
Alarin moderated myocardial hypertrophy via inhibiting cyclic adenosine monophosphate/protein kinase A signaling pathway to attenuate autophagy	9
A short framework-III (mini-M-2) conotoxin from the venom of a vermivorous species, Conus archon, inhibits human neuronal nicotinic acetylcholine receptors	9
Nociceptin/orphanin FQ receptor system blockade as an innovative strategy for increasing resilience to stress	9
AT2 receptor agonist LP2 restores respiratory function in a rat model of bleomycin-induced lung remodelling	9
Angiotensin-(1-7) reduces doxorubicin-induced aortic arch dysfunction in male and female juvenile Sprague Dawley rats through pleiotropic mechanisms	9
LP2, a cyclic angiotensin-(1−7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice	8
Functional role of immunoglobulin G as an oxytocin-carrier protein	8
Involvement of relaxin-family peptide-3 receptor (RXFP3) in the ventral dentate gyrus of the hippocampus in spatial and fear memory in rats	8
Modulatory role of PACAP and VIP on HIFs expression in lung adenocarcinoma	8
Host defense peptides at the crossroad of endothelial cell physiology: Insight into mechanistic and pharmacological implications	8
PD1 CD44 antiviral peptide as an inhibitor of the protein-protein interaction in dengue virus invasion	8
Diminazene Aceturate, an angiotensin converting enzyme 2 (ACE2) activator, promotes cardioprotection in ischemia/reperfusion-induced cardiac injury	8
The impact of GLP-1 signalling on the energy metabolism of pancreatic islet β-cells and extrapancreatic tissues	8
The proline-rich myticalins from Mytilus galloprovincialis display a membrane-permeabilizing antimicrobial mode of action	8
Discovery of the bioactive form of glucagon-like peptide-1: An attempt to correct some misconceptions	8
Heart peptides and HFpEF (heart failure with preserved ejection fraction)	8
Participation of angiotensin-(1-7) in exercise-induced analgesia in rats with neuropathic pain	8
The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin	7
Cbf-14, a cationic peptide derived from cathelin-domain, exhibits anti-inflammation activity via inhibiting PI3K- Akt /ROS/ NF-κB signaling pathway	7
History of peptide research: Ulf Svante von Euler's last visit to Yugoslavia	7
Transcriptomic and proteomic analyses of venom glands from scorpions Liocheles australasiae, Mesobuthus martensii, and Scorpio maurus palmatus	7
Irisin lowers blood pressure in Zucker diabetic rats by regulating the functions of renal angiotensin II type 1 receptor via the inhibition of the NF-κB signaling pathway	7
Optogenetics studies of kisspeptin neurons	7
Adropin: A cardio-metabolic hormone in the periphery, a neurohormone in the brain?	7
Amphibian host-defense peptides with potential for Type 2 diabetes therapy – an updated review	7
Protective effect of pituitary adenylate cyclase activating polypeptide in diabetic keratopathy	7
Viktor Mutt lecture: Peptides can cross the blood-brain barrier	7
The dual incretin co-agonist tirzepatide increases both insulin secretion and glucose effectiveness in model experiments in mice	7
Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals	7
Publishing in PEPTIDES − A 2022 update	7
Neprilysin deficiency reduces hepatic gluconeogenesis in high fat-fed mice	7
Peptides in the regulation of glucagon secretion	7
Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway	7
Evaluation of plasma arginine vasopressin during hypertonic saline loading: A comparison of radioimmunoassay and liquid chromatography–tandem mass spectrometry	7
Post-prandial secretion of glucagon-like peptide-2 (GLP-2) after carbohydrate-, fat- or protein enriched meals in healthy subjects	7
Isolation and characterization of FMRFamide-like peptides in the venoms of solitary sphecid wasps	7
Discovery of novel OXM-based glucagon-like peptide 1 (GLP-1)/glucagon receptor dual agonists	7
A murine model of obesity with hyperinsulinemia and hepatic steatosis involving neurosecretory protein GL gene and a low-fat/medium-sucrose diet	7
Identification and utility exploration of a highly potent and long-acting bullfrog GLP-1 analogue in GLP-1 and amylin combination therapy	7
Synthesis and characterization of piperic acid conjugates with homochiral and heterochiral dipeptides containing phenylalanine and their application in skin cancer	7
Antiosteoporosis effects of a marine antimicrobial peptide pardaxin via regulation of the osteogenesis pathway	7
Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives	7
Autonomic control of pancreatic beta cells: What is known on the regulation of insulin secretion and beta-cell proliferation in rodents and humans	7
The regulatory role of central neuropeptide-S in locomotion	7