OOIR: Observatory of International Research

Papers

(The TQCC of Peptides is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Transcardiac gradients of pro-cholecystokinin, cholecystokinin, and gastrin in patients with and without heart failure with reduced ejection fraction	108
Peptide antagonists of NMDA receptors: Structure-activity relationships for potential therapeutics	68
Corrigendum to “Oxytocin attenuates cardiac hypertrophy by improving cardiac glucose metabolism and regulating OXTR/JAK2/STAT3 axis” [Peptides 182 (2024) 171323]	67
Plant-derived peptides improving lipid and glucose metabolism	65
Synergistic interaction between DAMGO-NH2 and NOP01 in peripherally acting antinociception in two mouse models of formalin pain	58
Design of melanogenesis regulatory peptides derived from phycocyanin of the microalgae Spirulina platensis	47
Neandertal introgression and accumulation of hypomorphic mutations in the neuropeptide S (NPS) system promote attenuated functionality	46
Editorial Board	43
Intracerebroventricular administration of α-melanocyte-stimulating hormone (α-MSH) enhances thigmotaxis and induces anxiety-like behavior in the goldfish Carassius auratus	38
Neuropeptides affecting social behavior in mammals: Oxytocin	32
Dual-agonist incretin peptides from fish with potential for obesity-related Type 2 diabetes therapy – A review	32
NDP-MSH treatment recovers marginal lungs during ex vivo lung perfusion (EVLP)	31
Editorial Board	30
MicroRNA regulation of islet and enteroendocrine peptides: Physiology and therapeutic implications for type 2 diabetes	28
Transforming growth factor-β induced protein regulates pulmonary fibrosis via the G-protein signaling modulator 2 /Snail axis	27
Overexpressed beta cell CART increases insulin secretion in mouse models of insulin resistance and diabetes	26
Editorial Board	24
Irisin alleviates high glucose-induced hypertrophy in H9c2 cardiomyoblasts by inhibiting endoplasmic reticulum stress	24
Adropin transgenesis improves recognition memory in diet-induced obese LDLR-deficient C57BL/6J mice	23
ACE2 suppresses the inflammatory response in LPS-induced porcine intestinal epithelial cells via regulating the NF-κB and MAPK pathways	22
Orexin (hypocretin) participates in central autonomic regulation during fight-or-flight response	21
Serum alanine transaminase is predictive of fasting and postprandial insulin and glucagon concentrations in type 2 diabetes	20
Peripheral vs. core body temperature as hypocretin/orexin neurons degenerate: Exercise mitigates increased heat loss	20
Minimum biological domain of xenin-25 required to induce anion secretion in the rat ileum	19
Leupeptin maintains redox homeostasis via targeting ROS-autophagy-inflammatory axis in LPS-stimulated macrophages and cytokines dichotomy in Con-A challenged lymphocyte	19

Desacyl-ghrelin, not just an inactive form of ghrelin? A review of current knowledge on the biological actions of desacyl-ghrelin	19
Structural modifications of INGAP-PP present in HTD4010 peptide potentiate its effect on rat islet gene expression and insulin secretion.	19
Tachykinins amplify the action of capsaicin on central histaminergic neurons	18
FxRIamide regulates the oscillatory activity in the olfactory center of the terrestrial slug Limax	18
The actions of C-peptide in HEK293 cells are dependent upon insulin and extracellular glucose concentrations	18
Development of an automated, high-throughput assay to detect angiotensin AT2-receptor agonistic compounds by nitric oxide measurements in vitro	18
The brain oxytocin and corticotropin-releasing factor systems in grieving mothers: What we know and what we need to learn	18
The incessant increase curve during oral glucose tolerance tests in Chinese adults with type 2 diabetes and its association with gut hormone levels	17
Angiotensin-(1−7), a protective peptide against vascular aging	17
LC–MS/MS measurement of endogenous oxytocin in the posterior pituitary and CSF of macaques: A pilot study	17
Arterial responses to infusion of glucagon-like peptide-1 in humans: A randomized trial study	16
Corticotropin-releasing factor receptor 1 (CRF-R1) antagonists: Promising agents to prevent visceral hypersensitivity in irritable bowel syndrome	16
Role of VEGFB in electrical pulse stimulation inhibits apoptosis in C2C12 myotubes	16
Editorial Board	15
C-type natriuretic peptide in childhood obesity	15
In silico and in vivo experiment of soymilk peptide (tetrapeptide - FFYY) for the treatment of hypertension	15
The Mas agonist CGEN-856S prevents Ang II induced cardiomyocyte hypertrophy via nitric oxide production	15
Editorial Board	15
Duodenal enteroendocrine cells and GIP as treatment targets for obesity and type 2 diabetes	15
Natriuretic peptides potentiate cardiac hypertrophic response to noradrenaline in rats	15
The semenogelin I-derived peptide SgI-52 in seminal plasma participates in sperm selection and clearance by macrophages	14
Orexin/hypocretin	14
Design of peptides with high affinity binding to a monoclonal antibody as a basis for immunotherapy	14
2020 Invertebrate Neuropeptide Award Announcement	14
Irisin alleviates hyperoxia-induced bronchopulmonary dysplasia through activation of Nrf2/HO-1 pathway	14
Editorial Board	14
Editorial Board	14
Editorial Board	13
Hydrophobic diversification is the key to simultaneously increased antifungal activity and decreased cytotoxicity of two ab initio designed peptides	13
Emerging roles of oxyntomodulin-based glucagon-like peptide-1/glucagon co-agonist analogs in diabetes and obesity	13
Correlation between serum angiotensin-converting enzyme (ACE) levels and intervertebral disc degeneration	13
Discovery of once-weekly, peptide-based selective GLP-1 and cholecystokinin 2 receptors co-agonizts	13
Orexin-mediated motivated arousal and reward seeking	12
Recent articles highlighting the multifunctional character and wider therapeutic potential of antimicrobial peptides	12
The first structure-activity relationship study of oxytocin as a positive allosteric modulator for the µ opioid receptor	12
Interactions between nesfatin-1 and the autonomic nervous system—An overview	12
Neuropeptide Y gene variants in obesity, dietary intake, blood pressure, lipid and glucose metabolism: A longitudinal birth cohort study	12
Insulin-like growth factor 1 serum levels in different stages of gastric cancer and their association with Helicobacter pylori status	12
Purification and characterization of peptides Ap2, Ap3 and Ap5 (ω-toxins) from the venom of the Brazilian tarantula Acanthoscurria paulensis	12
Physiological role of K+ channels in irisin-induced vasodilation in rat thoracic aorta	12
PCP consensus protein/peptide alphavirus antigens stimulate broad spectrum neutralizing antibodies	11
Peripheral CRF-R1/CRF-R2 antagonist, astressin C, induces a long-lasting blockade of acute stress-related visceral pain in male and female rats	11
Harnessing the melanocortin system in the control of food intake and glucose homeostasis	11
Potential role of oxytocin in the regulation of memories and treatment of memory disorders	11
Intrathecal injections of angiotensin IV and oxytocin conjugates induce antihyperalgesia and antiallodynia in both sexes of rats	11
Roles of Angiotensin III in the brain and periphery	11
Alamandine attenuates oxidative stress in the right carotid following transverse aortic constriction in mice	11
KNDy neurons as the GnRH pulse generator: Recent studies in ruminants	10
Membrane alteration, anti-virulence properties and metabolomic perturbation of a chionodracine-derived antimicrobial peptide, KHS-Cnd, on two bacteria models	10
Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles	10

Incretin hormones, obesity and gut microbiota	10
Corrigendum to “Chronic catestatin treatment reduces atrial fibrillation susceptibility via improving calcium handling in post-infarction heart failure rats” Peptide 159(2023) 170904	10
Structure and function of cationic hylin bioactive peptides from the tree frog Boana pulchella in interaction with lipid membranes	10
Status of ghrelin as an islet hormone and paracrine/autocrine regulator of insulin secretion	10
Tirzepatide shows neuroprotective effects via regulating brain glucose metabolism in APP/PS1 mice	10
Angiotensin-(1−7) attenuates the negative inotropic response to acetylcholine in the heart	10
A review of the antiviral activity of cationic antimicrobial peptides	10
Cholecystokinin – portrayal of an unfolding peptide messenger system	10
Four sidenotes about glucagon peptides	10
The present and future of synthetic orexin receptor agonists	10
Hypothalamic kisspeptin neurons as potential mediators of estradiol negative and positive feedback	10
Semaglutide early intervention attenuated testicular dysfunction by targeting the GLP-1–PPAR-α–Kisspeptin–Steroidogenesis signaling pathway in a testicular ischemia-reperfusion rat model	10
In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues	10
Corrigendum to “Cyclopeptide Dmt-[D-Lys-p-CF3-Phe-Phe-Asp]NH2, a novel G protein-biased agonist of the mu opioid receptor” [Peptides 101 (2018) 227–233]	10
Gut hormone analogues and skeletal health in diabetes and obesity: Evidence from preclinical models	10
Altering Specificity and Enhancing Stability of the Antimicrobial Peptides Nisin and Rombocin through Dehydrated Amino Acid Residue Engineering	10
Characterization of rice endosperm-derived antidepressant-like peptide (REAP): An orally active novel tridecapeptide derived from rice protein	9
Oxytocin ameliorates KCC2 decrease induced by oral bacteria-derived LPS that affect rat primary cultured cells and PC-12 cells	9
The effect of acute exercise on pre-prandial ghrelin levels in healthy adults: A systematic review and meta-analysis	9
Angiotensin-(1-7) reduces doxorubicin-induced aortic arch dysfunction in male and female juvenile Sprague Dawley rats through pleiotropic mechanisms	9
Cathelicidin LL-37 promotes wound healing in diabetic mice by regulating TFEB-dependent autophagy	9
Serum CIAPIN1 is lower in septic patients with cardiac dysfunction	9
Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development	9
G-protein coupled receptor 30 attenuates myocardial hypertrophy by reducing oxidative stress and apoptosis in Ang II-treated mice	9
Chronic exposure to incretin metabolites GLP-1(9−36) and GIP(3−42) affect islet morphology and beta cell health in high fat fed mice	9
Nesfatin-1 peptide protects rat renal epithelial cells against high glucose and H2O2 induced injury via inhibition of oxidative stress, apoptosis, and fibrosis	9
Cm-p5, a molluscan-derived antifungal peptide exerts its activity by a membrane surface covering in a non-penetrating mode	9
Editorial Board	9
Engineering a potent and long-acting GLP-1/Y2 receptor dual agonist as a multi-agonist therapy for diabetes and obesity	9
Peptide‑based therapeutic strategies for glioma: Current state and prospects	9
Role of sexually dimorphic oxytocin receptor-expressing neurons in the anteroventral periventricular nucleus on maternal behavior	9
Urotensin II-related peptide (Urp) is expressed in motoneurons in zebrafish, but is dispensable for locomotion in larva	8
In memoriam: Dr. Stephen Tobe (11 October 1944 – 31 December 2020)	8
The hypothalamic neuropeptide, QRFP, regulates high fat diet intake in female Long-Evans rats following ovariectomy	8
Editorial Board	8
Acute social defeat stress upregulates gonadotrophin inhibitory hormone and its receptor but not corticotropin-releasing hormone and ACTH in the Male Nile Tilapia (Oreochromis niloticus)	8
Angiotensin-(1-7) protects against sepsis-associated left ventricular dysfunction induced by lipopolysaccharide	8
In memoriam - Patrick Robberecht (1944–2023)	8
Editorial Board	8
Introduction to special issue on feeding peptides	8
Editorial Board	8
The 2022 Kazuhiko Tatemoto Prize: ACE2-derived peptides for COVID-19 treatment	8
Interleukin-6, undercarboxylated osteocalcin, and brain-derived neurotrophic factor responses to single and repeated sessions of high-intensity interval exercise	8
The immunomodulatory functions of chromogranin A-derived peptide pancreastatin	7
Effect of PACAP on sweat secretion by immortalized human sweat gland cells	7
Involvement of orexin-2 receptors in the CA1 region of the hippocampus in the extinction and reinstatement of methamphetamine-induced conditioned place preference in the rats	7
Nesfatin-1 regulates steroidogenesis in mouse Leydig cells	7
Targeting of midkine alleviates cardiac hypertrophy via attenuation of oxidative stress and autophagy	7
Editorial Board	7
Growth hormone-releasing hormone antagonistic analog MIA-690 stimulates food intake in mice	7
Tick CAPA propeptide cDNAs and receptor activity of endogenous tick pyrokinins and analogs: Towards discovering pyrokinin function in ticks	7
AT2 receptor agonist LP2 restores respiratory function in a rat model of bleomycin-induced lung remodelling	7
NaHS restores the vascular alterations in the renin-angiotensin system induced by hyperglycemia in rats	7
Modulation of amylin and calcitonin receptor activation by hybrid peptides	7
Elevated Plasma Soluble (Pro)renin receptor as a potential indicator for heart failure	7
Blood and aqueous humor phoenixin, endocan and spexin in patients with diabetes mellitus and cataract with and without diabetic retinopathy	7
Editorial Board	7
Growth differentiation factor-15 modulates adrenocorticotropic hormone synthesis in murine AtT-20 corticotroph cells	7
Editorial Board	7
Contribution of the μ opioid receptor and enkephalin to the antinociceptive actions of endomorphin-1 analogs with unnatural amino acid modifications in the spinal cord	7
Endogenous opiates and behavior: 2022	7
Peptides and primate personality: Central and peripheral oxytocin and vasopressin levels and social behavior in two baboon species (Papio hamadryas and Papio anubis)	7
Chronic catestatin treatment reduces atrial fibrillation susceptibility via improving calcium handling in post-infarction heart failure rats	7
Prothymosin α-derived hexapeptide prevents the brain damage and sequelae due to ischemia-hemorrhage	7
Nesfatin-1 is involved in hyperbaric oxygen-mediated therapeutic effects in high fat diet-induced hyperphagia in mice	7
Abba J. Kastin – Obituary	7
Editorial Board	7
Effect of Fc-Elabela-21 on renal ischemia/reperfusion injury in mice: Mediation of anti-apoptotic effect via Akt phosphorylation	7
CCHamide2-receptor regulates feeding behavior in the pea aphid, Acyrthosiphon pisum	7
Irisin prevents hypoxic-ischemic brain damage in rats by inhibiting oxidative stress and protecting the blood-brain barrier	7