Neurobiology of Aging

Article	Citations
The genetic overlap between Alzheimer’s disease, amyotrophic lateral sclerosis, Lewy body dementia, and Parkinson’s disease	474
Machine learning approaches based on fibroblast morphometry do not predict ALS	185
Topological changes of fast large-scale brain dynamics in mild cognitive impairment predict early memory impairment: a resting-state, source reconstructed, magnetoencephalography study	100
Chronic BMAA exposure combined with TDP-43 mutation elicits motor neuron dysfunction phenotypes in mice	78
Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume	50
Gene age gap estimate (GAGE) for major depressive disorder: A penalized biological age model using gene expression	50
Paradoxical cognitive trajectories in men from earlier to later adulthood	48
Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions	47
Protein retention in the endoplasmic reticulum rescues Aβ toxicity in Drosophila	47
The association between hippocampal volume and memory in pathological aging is mediated by functional redundancy	45
Reactivity of posterior cortical electroencephalographic alpha rhythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and Lewy body diseases	44
Editorial Advisory Board	38
Isoform-specific effects of neuronal inhibition of AMPK catalytic subunit on LTD impairments in a mouse model of Alzheimer’s disease	37
Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with abnormalities in white matter structural integrity and connectivity: An ex-vivo diffusion MRI	36
CRYAB plays a role in terminating the presence of pro-inflammatory macrophages in the older, injured mouse peripheral nervous system	36
Trajectories of amyloid beta accumulation – Unveiling the relationship with APOE genotype and cognitive decline	35
Predicting brain atrophy and cognitive aging trajectories with baseline subjective cognitive concerns in cognitively normal older adults	34
Comparison of age-related declines in behavioral auditory responses versus electrophysiological measures of amplitude modulation	33
Low-moderate dose whole-brain γ-ray irradiation modulates the expressions of glial fibrillary acidic protein and intercellular adhesion molecule-1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine–i	33
Corrigendum to “Progesterone exerts neuroprotective effects and improves long-term neurologic outcome after intracerebral hemorrhage in middle-aged mice” [Neurobiol. Aging 42 (2016) 13–24]	30
Age-related differences in ERP correlates of value-based decision making	30
Divergent magnetic resonance imaging atrophy patterns in Alzheimer's disease and primary age-related tauopathy	30
Contents	29
Contents	29
Medial temporal lobe structure, mnemonic and perceptual discrimination in healthy older adults and those at risk for mild cognitive impairment	28

Mitochondrial pathway polygenic risk scores are associated with Alzheimer's Disease	28
A cognitive marker for Alzheimer disease pathology in primary progressive aphasia? A validation study in the clinical setting	27
Altered network stability in progressive supranuclear palsy	27
Spontaneous prion disease in homozygous and heterozygous transgenic mouse models of T188K genetic Creutzfeldt-Jakob disease	27
Blood pressure changes impact corticospinal integrity and downstream gait and balance control	27
Age-dependent relationship of cardiorespiratory fitness and white matter integrity	27
DNA methylation age acceleration is associated with age of onset in Chinese spinocerebellar ataxia type 3 patients	27
Association between metabolic syndrome and resting-state functional brain connectivity	26
Associations of cerebrovascular disease and Alzheimer’s disease pathology with cognitive decline: Analysis of the National Alzheimer’s Coordinating Center Uniform Data Set	26
Actigraphy-estimated physical activity is associated with functional and structural brain connectivity among older adults	25
Recollection-related fMRI effects in entorhinal cortex predict longitudinal memory change in healthy older adults	25
Exploring the links among brain iron accumulation, cognitive performance, and dietary intake in older adults: A longitudinal MRI study	25
Relationship between regional white matter hyperintensities and alpha oscillations in older adults	25
Effector-dependent decline in strength and subcortical motor excitability with aging	25
Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer’s disease	24
Sleep/wake cycle alterations as a cause of neurodegenerative diseases: A Mendelian randomization study	24
Impact of white matter hyperintensities on structural connectivity and cognition in cognitively intact ADNI participants	24
Do age-related differences in aperiodic neural activity explain differences in resting EEG alpha?	24
Genotype-phenotype correlation of Parkinson's disease with PRKN variants	24
Dynactin 6 deficiency enhances aging-associated dystrophic neurite formation in mouse brains	24
White matter hyperintensities in dementia with lewy bodies and posterior cortical atrophy	23
Zebrafish optomotor response to second-order motion illustrates that age-related changes in motion detection depend on the activated motion system	23
Editorial Advisory Board	23
Nigrostriatal 6-hydroxydopamine lesions increase alpha-synuclein levels and permeability in rat colon	23
More flexible brain activation underlies cognitive reserve in older adults	23
Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigra	23
Exploring the domain specificity and the neural correlates of memory unawareness in Alzheimer's disease	23
ANXA1 mutation analysis in Italian patients with early onset PD	23
Editorial: Guide for authors at Neurobiology of Aging	22
Resting-state functional connectivity abnormalities in subjective cognitive decline: A 7T MRI study	22
Contents	22
TFEB protein expression is reduced in aged brains and its overexpression mitigates senescence-associated biomarkers and memory deficits in mice	22
Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with lower R2 relaxation rate: an ex-vivo MRI and pathology investigation	22
ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease	22
Increased neural differentiation after a single session of aerobic exercise in older adults	22
GABAA receptor agonist muscimol rescues inhibitory microcircuit defects in the olfactory bulb and improves olfactory function in APP/PS1 transgenic mice	22
Voice biomarkers as indicators of cognitive changes in middle and later adulthood	22
Principal components from untargeted cerebrospinal fluid metabolomics associated with Alzheimer's disease biomarkers	21
Apolipoprotein E and Alzheimer’s disease pathology in African American older adults	21
High-fat diet and aging-associated memory impairments persist in the absence of microglia in female rats	21
Dynamics and role of covalently-closed circular RNAs in Alzheimer's disease: A review of experimental and bioinformatics studies	21
Editorial Advisory Board	21
Examining age-dependent DNA methylation patterns and gene expression in the male and female mouse hippocampus	21
Distinct phosphorylation profiles of tau in brains of patients with different tauopathies	21
The moderating effect of diet on the relationship between depressive symptoms and Alzheimer’s disease-related blood-based biomarkers	20
Neuropsychology of cognitive aging in rhesus monkeys	20
Adult lifespan maturation and degeneration patterns in gray and white matter: A mean apparent propagator (MAP) MRI study	20
Single-neuron whole genome sequencing identifies increased somatic mutation burden in Alzheimer's disease related genes	20
Hearing loss and its relation to longitudinal changes in white matter microstructure in older adults: The Rotterdam Study	20
EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel	19

Visit-to-visit blood pressure variability and regional cerebral perfusion decline in older adults	19
Contents	19
Mediterranean diet is associated with lower white matter lesion volume in Mediterranean cities and lower cerebrospinal fluid Aβ42 in non-Mediterranean cities in the EPAD LCS cohort	19
Reduced structural connectivity of the medial temporal lobe including the perforant path is associated with aging and verbal memory impairment	19
Contents	19
Age-related decline in cochlear ribbon synapses and its relation to different metrics of auditory-nerve activity	19
Contents	19
Rates of β-amyloid deposition indicate widespread simultaneous accumulation throughout the brain	19
Mutation analysis of seven SLC family transporters for early-onset Parkinson's disease in Chinese population	18
Editorial Advisory Board	18
Previous estradiol treatment during midlife maintains transcriptional regulation of memory-related proteins by ERα in the hippocampus in a rat model of menopause	18
Persistent blood-brain barrier dysregulation in patients with obstructive sleep apnea following long-term continuous positive airway pressure treatment	18
Patterns of amyloid accumulation in amyloid-negative cases	18
Age-related differences in how the shape of alpha and beta oscillations change during reaction time tasks	18
Electrophysiological alterations during action semantic processing in Parkinson’s disease	18
Genetic overlap between Alzheimer's disease and blood lipid levels	18
Characterising the covariance pattern between lifestyle factors and structural brain measures: a multivariable replication study of two independent ageing cohorts	18
Whole genome sequencing analysis reveals post-zygotic mutation variability in monozygotic twins discordant for amyotrophic lateral sclerosis	18
Biological correlates of elevated soluble TREM2 in cerebrospinal fluid	18
Biologic that disrupts PDE11A4 homodimerization in hippocampus CA1 reverses age-related cognitive decline of social memories in mice	18
Editorial Advisory Board	18
Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults	18
Physical activity levels and brain structure in middle-aged and older adults: a bidirectional longitudinal population-based study	18
The (hyper)excitable brain: what can a ubiquitous TMS measure reveal about cognitive aging?	18
Healthy dietary intake moderates the effects of age on brain iron concentration and working memory performance	17
Age differences in the neural processing of semantics, within and beyond the core semantic network	17
1H MR spectroscopy biomarkers of neuronal and synaptic function are associated with tau deposition in cognitively unimpaired older adults	17
Ensemble-specific deficit in neuronal intrinsic excitability in aged mice	17
Corrigendum to: A clinical, molecular genetics and pathological study of a FTDP-17 family with a heterozygous splicing variant c.823–10 G>T at the intron 9/exon 10 of the MAPT gene	17
The association between inadequate sleep and accelerated brain ageing	17
APOE4 homozygote females are resistant to the beneficial effects of 17β-estradiol on memory and CA1 dendritic spine density in the EFAD mouse model of Alzheimer's disease	17
Editorial Advisory Board	17
Modeling functional loss in Alzheimer’s Disease through cognitive reserve and cognitive state: A panel data longitudinal study	17
Contents	16
Brain oscillatory processes related to sequence memory in healthy older adults	16
CSF peptides from VGF and other markers enhance prediction of MCI to AD progression using the ATN framework	16
Higher motor cortical excitability linked to greater cognitive dysfunction in Alzheimer's disease: results from two independent cohorts	16
Unique regional patterns of amyloid burden predict progression to prodromal and clinical stages of Alzheimer's disease	16
Predicting time-to-conversion for dementia of Alzheimer's type using multi-modal deep survival analysis	16
Mutation analysis of the ECE1 gene in late-onset Alzheimer’s disease	16
Age differences in the neural correlates of recollection: transient versus sustained fMRI effects	16
Neuropathologic correlates of cerebral microbleeds in community-based older adults	16
Blood-brain barrier water permeability across the adult lifespan: A multi-echo ASL study	16
Depressive symptoms are associated with reduced positivity preferences in episodic memory in aging	16
Genotype-phenotype correlation in Tunisian patients with Amyotrophic Lateral Sclerosis	16
Editorial Advisory Board	16
ANXA1 and the risk for early-onset Parkinson's disease	16
The links among age, sex, and glutathione: A cross-sectional magnetic resonance spectroscopy study	16
Neural correlates of metacognition across the adult lifespan	16
Free water-corrected fractional anisotropy of the fornix and parahippocampal cingulum predicts longitudinal memory change in cognitively healthy older adults	16
Associations of brain morphology with cortical proteins of cognitive resilience	16
Signatures for viral infection and inflammation in the proximal olfactory system in familial Alzheimer's disease	16
Contents Continued	15
Contents Continued	15
Shared and oppositely regulated transcriptomic signatures in Huntington's disease and brain ischemia confirm known and unveil novel potential neuroprotective genes	15
Commentary on "A framework for concepts of reserve and resilience in aging"	15
Contents Continued	15
Contents	15
Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population.	15
Editorial Advisory Board	15
Editorial Advisory Board	15
Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice	15
The effects of age bias on neural correlates of successful and unsuccessful response inhibition in younger and older adults	15
Loss of SST and PV positive interneurons in the ventral hippocampus results in anxiety-like behavior in 5xFAD mice	14
Genetic and clinical characteristics of ALS patients with NEK1 gene variants	14
Assessment of ANG variants in Parkinson's disease	14
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer’s disease progression	14
CSF phosphorylated tau as an indicator of subsequent tau accumulation	14
Contents	14
Re-analysis of the Hungarian amyotrophic lateral sclerosis population and evaluation of novel ALS genetic risk variants	14
Brain reserve in midlife is associated with executive function changes across 12 years	14
Cognitive reserve proxies are associated with age-related cognitive decline – Not age-related gait speed decline	14
Cortical network modularity changes along the course of frontotemporal and Alzheimer's dementing diseases	14
Excitatory and inhibitory neurotransmitter alterations with advancing age and injury in the mouse retina	14
Generating diagnostic profiles of cognitive decline and dementia using magnetoencephalography	14
Contents Continued	14
The shared genetic architecture of modifiable risk for Alzheimer's disease: a genomic structural equation modelling study	14
Dynamic interplay of frontoparietal cholinergic innervation and cortical reorganization in the regulation of attentional capacities in aging	14
DKI enhances the sensitivity and interpretability of age-related DTI patterns in the white matter of UK biobank participants	14
Matrix metalloproteinases are associated with brain atrophy in cognitively unimpaired individuals	14

Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease	14
Lower oddball event-related EEG delta and theta responses in patients with dementia due to Parkinson's and Lewy body than Alzheimer's disease	14
White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer’s disease continuum	14
Contents	14
Lack of limbic-predominant age-related TDP-43 encephalopathy (LATE) neuropathological changes in aged macaques with memory impairment	14
Contents Continued	14
Editorial Advisory Board	13
Study of Alzheimer's disease- and frontotemporal dementia-associated genes in the Cretan Aging Cohort	13
A ketogenic intervention improves dorsal attention network functional and structural connectivity in mild cognitive impairment	13
Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice	13
Brain structural indicators of β-amyloid neuropathology	13
Associations between phasic arousal and decisions under risk in younger and older adults	13
Contents Continued	13
Hypothalamic MRI-derived microstructure is associated with neurocognitive aging in humans	13
Aging of gray matter microstructure: A brain-wide characterization of age group differences using NODDI	13
Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease	13
Tau in the brain interstitial fluid is fragmented and seeding–competent	13
Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease	13
Corrigendum to “Dissemination in time and space in presymptomatic granulin mutation carriers: A spatial chronnectome study” [Neurobiology of Aging Volume 108, December 2021, Pages 155–167]	13
Contents	13
Hippocampal atrophy over two years in relation to tau, amyloid-β and memory in older adults	13
Editorial Advisory Board	13
The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer's disease mouse model	13
NPC1 variants are not associated with Parkinson’s disease, REM-sleep behavior disorder or dementia with Lewy bodies in European cohorts	13
Age-related similarities and differences in cognitive and neural processing revealed by task-related microstate analysis	13
RETRACTED: Age-related declines in neural selectivity manifest differentially during encoding and recognition	13
Aging induces abnormal accumulation of Aβ in extracellular vesicle and/or intraluminal membrane vesicle-rich fractions in nonhuman primate brain	12
Operationally defining cognitive reserve genes	12
Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome	12
Editorial Advisory Board	12
Moderating effects of cognitive reserve on the relationship between brain structure and cognitive abilities in middle-aged and older adults	12
Auditory robustness and resilience in the aging auditory system of the desert locust	12
Predicting future cognitive decline from non-brain and multimodal brain imaging data in healthy and pathological aging	12
Myelin, aging, and physical exercise	12
Gene-based burden analysis of damaging private variants in PRKN, PARK7 and PINK1 in Parkinson's disease cohorts of European descent	12
Contents Continued	12
C-reactive protein and risk of Alzheimer's disease	12
Impact of thyroid hormone perturbations in adult mice: brain weight and blood vessel changes, gene expression variation, and neurobehavioral outcomes	12
Relation of MRI visible perivascular spaces with global and regional brain structural connectivity measures: The Framingham Heart Study (FHS)	12
The relationship of glucose-stimulated insulin secretion to cerebral glucose metabolism and cognition in healthy middle-aged and older adults	12
Analysis of NOTCH2NLC GGC repeat expansion in Taiwanese patients with amyotrophic lateral sclerosis	12
Aging induces cell loss and a decline in phagosome processing in the mouse retinal pigment epithelium	12
Sulcal morphology as cognitive decline predictor in older adults with memory complaints	12
Preventive effect of propolis on cognitive decline in Alzheimer’s disease model mice	12
Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden	12
Heterogenous response to aging of astrocytes in murine Substantia Nigra pars compacta and pars reticulata	11
Beyond group classification: Probabilistic differential diagnosis of frontotemporal dementia and Alzheimer’s disease with MRI and CSF biomarkers	11
Extracellular matrix proteoglycans support aged hippocampus networks: a potential cellular-level mechanism of brain reserve	11
Corrigendum to “Longitudinal characterization of neuroanatomical changes in the Fischer 344 rat brain during normal aging and between sexes [neurobiology of aging. 109 (2022) 216–228]”	11
Age-related dedifferentiation and hyperdifferentiation of perceptual and mnemonic representations	11
Editorial Advisory Board	11
Contents	11
Neural atrophy produced by AAV tau injections into hippocampus and anterior cortex of middle-aged mice	11
Contents	11
Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients	11
Comparing neural activity during autobiographical memory retrieval between younger and older adults: An ALE meta-analysis	11
Identification and functional characterization of novel variants of MAPT and GRN in Chinese patients with frontotemporal dementia	11
Contents Continued	11
Resting state electroencephalographic alpha rhythms are sensitive to Alzheimer’s disease mild cognitive impairment progression at a 6-month follow-up	11
Explaining tip-of-the-tongue experiences in older adults: The role of brain-based and cardiorespiratory fitness factors	11
Editorial Advisory Board	11
Alzheimer-like pathology in the parietal cortex and hippocampus of aged donkeys	11
A genome-wide association study of plasma phosphorylated tau181	11
Neuronal hyperexcitability in the Tg2576 mouse model of Alzheimer's disease – the influence of sleep and noradrenergic transmission	11
A novel presenilin 1 duplication mutation (Ile168dup) causing Alzheimer's disease associated with myoclonus, seizures and pyramidal features	11
Longitudinal associations of absolute versus relative moderate-to-vigorous physical activity with brain microstructural decline in aging	11
Absence of coding somatic single nucleotide variants within well-known candidate genes in late-onset sporadic Alzheimer's Disease based on the analysis of multi-omics data	11
Multimodal investigation of neuropathology and neurometabolites in mild cognitive impairment and late-life depression with 11C-PiB beta-amyloid PET and 7T magnetic resonance spectroscopy	11
Fiber-specific age-related differences in the white matter of healthy adults uncovered by fixel-based analysis	11
Contents	11
Associations of increased interstitial fluid with vascular and neurodegenerative abnormalities in a memory clinic sample	11
Exploring graded profiles of hippocampal atrophy along the anterior-posterior axis in semantic dementia and Alzheimer’s disease	11
Racial differences in white matter hyperintensity burden in older adults	11
Brain connectivity in frailty: Insights from The Irish Longitudinal Study on Ageing (TILDA)	10
Cortical axon sub-population maintains density, but not turnover, of en passant boutons in the aged APP/PS1 amyloidosis model	10
Hippocampal shape across the healthy lifespan and its relationship with cognition	10
Pathological tau and reactive astrogliosis are associated with distinct functional deficits in a mouse model of tauopathy	10
Decomposing neurophysiological underpinnings of age-related decline in visual working memory	10
Inverse correlation between Alzheimer’s disease and cancer from the perspective of hypoxia	10
Cerebrovascular response to exercise interacts with individual genotype and amyloid-beta deposition to influence response inhibition with aging	10
Neuronal vulnerability to brain aging and neurodegeneration in cognitively impaired marmoset monkeys (Callithrix jacchus)	10
Cognitive reserve moderates the association between cerebral blood flow and language performance in older adults with mild cognitive impairment	10
Alzheimer’s disease cerebrospinal fluid biomarker levels and APOE genetic status are associated with hippocampal-cerebellar functional connectivity	10
Genetic analyses in multiplex families confirms chromosome 5q35 as a risk locus for Alzheimer’s Disease in individuals of African Ancestry	10
Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome	10
Sex differences in plasma lipid profiles of accelerated brain aging	10
Longitudinal assessment of cognitive function in the APPswe/PS1dE9 mouse model of Alzheimer’s-related beta-amyloidosis	10
Variants in the Niemann-pick type C genes are not associated with Alzheimer's disease: a large case-control study in the Chinese population	10
Editorial Advisory Board	10
Dissemination in time and space in presymptomatic granulin mutation carriers: a GENFI spatial chronnectome study	10
Nicotine reduces age-related changes in cortical neural oscillations without affecting auditory brainstem responses	10
Association between WWOX/MAF variants and dementia-related neuropathologic endophenotypes	10
Contributions of mouse genetic strain background to age-related phenotypes in physically active HET3 mice	10
Contents Continued	10
Amyloid toxicity in a Drosophila Alzheimer's model is ameliorated by autophagy activation	10