Neurobiology of Aging

Article	Citations
Region-specific and age-related differences in astrocytes in the human brain	419
Chronic BMAA exposure combined with TDP-43 mutation elicits motor neuron dysfunction phenotypes in mice	154
Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions	84
Depthwise cortical iron relates to functional connectivity and fluid cognition in healthy aging	83
Inter-network functional connectivity increases by beta-amyloid and may facilitate the early stage of tau accumulation	73
The association between personality and plasma biomarkers of astrogliosis and neuronal injury	50
Lower oddball event-related EEG delta and theta responses in patients with dementia due to Parkinson's and Lewy body than Alzheimer's disease	48
Genotype-phenotype correlation in Tunisian patients with Amyotrophic Lateral Sclerosis	47
The genetic overlap between Alzheimer’s disease, amyotrophic lateral sclerosis, Lewy body dementia, and Parkinson’s disease	47
A novel 14mer peptide, T14, is associated with age-dependent behaviour in female mice	46
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer’s disease progression	45
Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults	43
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Sex and APOE genotype differences in amyloid deposition and cognitive performance along the Alzheimer’s Continuum	42
Biomarkers of Alzheimer’s disease in Black and/or African American Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants	41
Midlife physical activity engagement is associated with later-life brain health	38
CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia	37
Diffusion tensor-based analysis of white matter in the healthy aging canine brain	36
Poor reactivity of posterior electroencephalographic alpha rhythms during the eyes open condition in patients with dementia due to Parkinson’s disease	35
Evidence from theta-burst stimulation that age-related de-differentiation of the hippocampal network is functional for episodic memory	35
Explainable artificial intelligence identifies an AQP4 polymorphism-based risk score associated with brain amyloid burden	34
Specific microglial phagocytic phenotype and decrease of lipid oxidation in white matter areas during aging: Implications of different microenvironments	34
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Editorial Advisory Board	32

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Editorial Advisory Board	30
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Dissociating effects of aging and genetic risk of sporadic Alzheimer’s disease on path integration	28
Editorial Advisory Board	28
The effects of age bias on neural correlates of successful and unsuccessful response inhibition in younger and older adults	28
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Cerebral blood flow predicts multiple demand network activity and fluid intelligence across the adult lifespan	27
TREX1 p.A129fs and p.Y305C variants in a large multi-ethnic cohort of CADASIL-like unrelated patients	27
Amyloid β oligomers disrupt piriform cortical output via a serotonergic pathway	27
Commentary on "A framework for concepts of reserve and resilience in aging"	26
Editorial Advisory Board	26
Degeneration of cholinergic white matter pathways and nucleus basalis of Meynert in individuals with objective subtle cognitive impairment	26
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Reactivity of posterior cortical electroencephalographic alpha rhythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and Lewy body diseases	24
Paradoxical cognitive trajectories in men from earlier to later adulthood	24
Proteomic correlates of cortical thickness in cognitively normal individuals with normal and abnormal cerebrospinal fluid beta-amyloid1-42	24
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Methylome analysis of ALS patients and presymptomatic mutation carriers in blood cells	23
Protein retention in the endoplasmic reticulum rescues Aβ toxicity in Drosophila	23
Life-long dietary restrictions have negligible or damaging effects on late-life cognitive performance: A key role for genetics in outcomes	23
Elevated levels of tripeptidyl peptidase 1 do not ameliorate pathogenesis in a mouse model of Alzheimer disease	23
Variability in sub-threshold signaling linked to Alzheimer's disease emerges with age and amyloid plaque deposition in mouse ventral CA1 pyramidal neurons	23
Age-related changes in midfrontal theta activity during steering control: A driving simulator study	22
Lifelong experiences as a proxy of cognitive reserve moderate the association between connectivity and cognition in Alzheimer's disease	22
Rare genetic variants correlate with better processing speed	22
Genetic and clinical characteristics of ALS patients with NEK1 gene variants	22
Genetic correlation and gene-based pleiotropy analysis for four major neurodegenerative diseases with summary statistics	22
Genome-wide association study of executive function in a multi-ethnic cohort implicates LINC01362: Results from the northern Manhattan study	22
MAPT rs17649553 T allele is associated with better verbal memory and higher small-world properties in Parkinson’s disease	22
Phases of volume loss in patients with known frontotemporal lobar degeneration spectrum pathology	22
White matter degradation near cerebral microbleeds is associated with cognitive change after mild traumatic brain injury	22
Machine learning approaches based on fibroblast morphometry do not predict ALS	22
Topological changes of fast large-scale brain dynamics in mild cognitive impairment predict early memory impairment: a resting-state, source reconstructed, magnetoencephalography study	21
Childhood engagement in cognitively stimulating activities moderates relationships between brain structure and cognitive function in adulthood	21
The associations among glycemic control, heart variability, and autonomic brain function in healthy individuals: Age- and sex-related differences	21
Long-term olfactory enrichment promotes non-olfactory cognition, noradrenergic plasticity and remodeling of brain functional connectivity in older mice	21
Improvement of mnemonic discrimination with acute light exercise is mediated by pupil-linked arousal in healthy older adults	21
Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory	21
Contributions of hippocampal subfields and subregions to episodic memory performance in healthy cognitive aging	21
The hippocampus as a structural and functional network epicentre for distant cortical thinning in neurocognitive aging	21
Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline	21
Lack of evidence for association of UQCRC1 with Parkinson's disease in Europeans	20
Event-related potential evidence that very slowly presented auditory stimuli are passively processed differently in younger and older adults	20
The histone acylation reader ENL/AF9 regulates aging in Drosophila melanogaster	20
Association of rare heterozygous PLA2G6 variants with the risk of Parkinson's disease	20
Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice	20
Longitudinal relationships between Aβ and tau to executive function and memory in cognitively normal older adults	20

Translation of the poly(GR) frame in C9ORF72-ALS/FTD is regulated by cis-elements involved in alternative splicing	20
Structural brain correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study	20
Cognitive reserve proxies are associated with age-related cognitive decline – Not age-related gait speed decline	20
Sex differences in dopamine integrity and brain structure among healthy older adults: Relationships to episodic memory	19
Assessment of LIN28A variants in Parkinson's disease in large European cohorts	19
GABA levels in ventral visual cortex decline with age and are associated with neural distinctiveness	19
Greater white matter hyperintensities and the association with executive function in suicide attempters with late-life depression	19
Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging	19
Phasic alerting increases visual processing speed in amnestic mild cognitive impairment	19
Enriching activities during childhood are associated with variations in functional connectivity patterns later in life	19
Effects of age on goal-dependent modulation of episodic memory retrieval	19
Assessment of ANG variants in Parkinson's disease	18
Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort	18
Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population.	18
Effects of baseline serum uric acid and apolipoprotein E4 on longitudinal cognition and cerebral metabolism	18
Amyloid-β (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex	18
Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[18F]fluoro-L-m-tyrosine imaging and motor performances analysis	18
Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume	18
Default mode network connectivity and cognition in the aging brain: the effects of age, sex, and APOE genotype.	18
Shared and oppositely regulated transcriptomic signatures in Huntington's disease and brain ischemia confirm known and unveil novel potential neuroprotective genes	18
Analysis of PTRHD1 common and rare variants in European patients with Parkinson's disease	18
Apolipoprotein E4, amyloid, and cognition in Alzheimer's and Lewy body disease	17
Longitudinal characterization of neuroanatomical changes in the Fischer 344 rat brain during normal aging and between sexes	17
Age-related impairments on the touchscreen paired associates learning (PAL) task in male rats	17
Physical activity and amyotrophic lateral sclerosis: a Mendelian randomization study	17
Neural regions associated with gain-loss frequency and average reward in older and younger adults	17
Positivity effect in aging: evidence for the primacy of positive responses to emotional ambiguity	17
Age, sex, and cerebral microbleeds in EFAD Alzheimer disease mice	17
Expression and proteolytic processing of the amyloid precursor protein is unaffected by the expression of the three human apolipoprotein E alleles in the brains of mice	17
Cortical network modularity changes along the course of frontotemporal and Alzheimer's dementing diseases	17
Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study	16
Biophysical and synaptic properties of regular spiking interneurons in hippocampal area CA3 of aged rats	16
Perivascular space burden interacts with APOE-ε4 status on cognition in older adults	16
Development and validation of a 13-gene signature associated with immune function for the detection of Alzheimer's disease	16
Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females	16
Lateral entorhinal cortex dysfunction in amnestic mild cognitive impairment	16
Association of plasma Aβ40/Aβ42 ratio and brain Aβ accumulation: testing a whole-brain PLS-VIP approach in individuals at risk of Alzheimer's disease	16
Enlarged perivascular space burden associations with arterial stiffness and cognition	16
Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease	16
Editorial Advisory Board	16
WITHDRAWN: Assessment and Validation of Globodera pallida as a Novel In Vivo Model for Studying Alzheimer's Disease	16
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Reward motivation and cognitive flexibility in tau null-mutation mice	16
Sex differences in the IntelliCage and the Morris water maze in the APP/PS1 mouse model of amyloidosis	16
Dose‐dependent relationship between social drinking and brain aging	15
Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease	15
Role and molecular regulatory mechanisms of Hippo signaling pathway in Caenorhabditis elegans and mammalian cell models of Alzheimer’s disease	15
Age-related differences in functional connectivity associated with pain modulation	15
Distant histories of mild traumatic brain injury exacerbate age-related differences in white matter properties	15
Age-related differences in the social associative learning of trust information	15
The association between hippocampal volume and memory in pathological aging is mediated by functional redundancy	15
Generating diagnostic profiles of cognitive decline and dementia using magnetoencephalography	15
Loss of SST and PV positive interneurons in the ventral hippocampus results in anxiety-like behavior in 5xFAD mice	15
Are sex differences in cognitive impairment reflected in epigenetic age acceleration metrics?	15
Editorial Advisory Board	15
Association of homocysteine-related subcortical brain atrophy with white matter lesion volume and cognition in healthy aging	15
Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis	15
Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes	15
Microvascular degeneration occurs before plaque onset and progresses with age in 3xTg AD mice	15
Expression of Concern: Wang et al., (2017) PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol. Aging, 55:99-114	15
Resting EEG power spectra across middle to late life: associations with age, cognition, APOE-ɛ4 carriage, and cardiometabolic burden	15
Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer's disease	15
Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk	14
Preoperative MRI brain phenotypes are related to postoperative delirium in older individuals	14
Matrix metalloproteinases are associated with brain atrophy in cognitively unimpaired individuals	14
NLX-101, a 5-HT1A receptor-biased agonist, improves pattern separation and stimulates neuroplasticity in aged rats	14
Network segregation during episodic memory shows age-invariant relations with memory performance from 7 to 82 years	14
Validation of the pathogenic role of rare DNAJC7 variants in Chinese patients with amyotrophic lateral sclerosis	14
Low-degree trisomy 21 mosaicism promotes early-onset Alzheimer disease	14
Weak-hyperactive hippocampal CA1 neurons in the prodromal stage of Alzheimer's disease in hybrid AppNL-G-F/NL-G-F × Thy1-GCaMP6s+/− mice suggest disrupted plasticity	14
DAT1 and BDNF polymorphisms interact to predict Aβ and tau pathology	14
Changes in cerebral arterial pulsatility and hippocampal volume: a transcranial doppler ultrasonography study	14
Editorial Advisory Board	14
White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia	14
Cerebrovascular reactivity deficits in cognitively unimpaired older adults: vasodilatory versus vasoconstrictive responses	14
Racial and ethnic differences in the relationship between financial worry and white matter hyperintensities in Latinx, non-Latinx Black, and non-Latinx White older adults	14
Selective spatial attention in lateralized multi-talker speech perception: EEG correlates and the role of age	14
A suggested shared aetiology of dementia - a colocalization study	14
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The shared genetic architecture of modifiable risk for Alzheimer's disease: a genomic structural equation modelling study	13
Re-analysis of the Hungarian amyotrophic lateral sclerosis population and evaluation of novel ALS genetic risk variants	13
A cognitive marker for Alzheimer disease pathology in primary progressive aphasia? A validation study in the clinical setting	13
Corrigendum to “Progesterone exerts neuroprotective effects and improves long-term neurologic outcome after intracerebral hemorrhage in middle-aged mice” [Neurobiol. Aging 42 (2016) 13–24]	13
Improving brain age estimates with deep learning leads to identification of novel genetic factors associated with brain aging	13
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Adulthood cognitive trajectories over 26 years and brain health at 70 years of age: findings from the 1946 British Birth Cohort	13
Modifiable risk factors for dementia, cognition, and plasma phosphorylated tau 181 in a large-scale cohort of Australian older adults	13
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White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer’s disease continuum	13
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Plasma neurofilament light and brain volumetric outcomes among middle-aged urban adults	13
Rare exonic variant affects GRN splicing and contributes to frontotemporal lobar degeneration	13
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Linking early-life bilingualism and cognitive advantage in older adulthood	13
Editorial Advisory Board	13
Mitochondrial pathway polygenic risk scores are associated with Alzheimer's Disease	13
Atypical paroxysmal slow cortical activity in healthy adults: Relationship to age and cognitive performance	13
Disease trajectories in older adults with non-AD pathologic change and comparison with Alzheimer’s disease pathophysiology: A longitudinal study	13
Comparing three neuropsychological subgrouping approaches in subjective and mild cognitive impairment from a naturalistic multicenter study	13
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Editorial Advisory Board	12
DNA methylation age acceleration is associated with age of onset in Chinese spinocerebellar ataxia type 3 patients	12
Authors’ reply: Four novel optineurin mutations in patients with sporadic amyotrophic lateral sclerosis in Mainland China	12
Editorial Advisory Board	12
TSPO deficiency accelerates amyloid pathology and neuroinflammation by impairing microglial phagocytosis	12
Editorial Advisory Board	12
Independent role of Alzheimer's disease genetics and C-reactive protein on cognitive ability in aging	12
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Lack of limbic-predominant age-related TDP-43 encephalopathy (LATE) neuropathological changes in aged macaques with memory impairment	12
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Fatal attraction – The role of hypoxia when alpha-synuclein gets intimate with mitochondria	12
9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer’s disease neuropathology and neuroinflammation in Alzheimer’s disease-like mouse models	12
Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer's Disease	12
Limbic thalamus atrophy is associated with visual hallucinations in Lewy body disorders	12
Temporal acuity is preserved in the auditory midbrain of aged mice	12
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Genotype-phenotype correlation of Parkinson's disease with PRKN variants	12
DKI enhances the sensitivity and interpretability of age-related DTI patterns in the white matter of UK biobank participants	12
Blood pressure changes impact corticospinal integrity and downstream gait and balance control	12
Do age-related differences in aperiodic neural activity explain differences in resting EEG alpha?	11
Effector-dependent decline in strength and subcortical motor excitability with aging	11
Age-dependent relationship of cardiorespiratory fitness and white matter integrity	11
Disappearing metabolic youthfulness in the cognitively impaired female brain	11
Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis	11
Ethnic differences in the frequency of β-amyloid deposition in cognitively normal individuals	11
Exploring the links among brain iron accumulation, cognitive performance, and dietary intake in older adults: A longitudinal MRI study	11
Retraction notice to “Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer’s disease” [Neurobiology of Aging Volume 68, August 2018, Page 59-67]	11
Sex differences in the relationship between age, performance, and BOLD signal variability during spatial context memory processing	11
NPC1 variants are not associated with Parkinson’s disease, REM-sleep behavior disorder or dementia with Lewy bodies in European cohorts	11
White matter lesion load is associated with lower within- and greater between- network connectivity across older age	11
Corrigendum to “Modulation of lipopolysaccharide-induced memory insult, g-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase” [Neurobiol. Aging 35 (2014) 1024–1031 ]	11
Cardiovascular risk of dementia is associated with brain–behaviour changes in cognitively healthy, middle-aged individuals	11
Age-related differences in encoding-retrieval similarity and their relationship to false memory	11
Auditory distraction, time perception, and the role of age: ERP evidence from a large cohort study	11
Independent associations of sleep and physical activity with cognition are mediated by hippocampal microstructure in middle-aged and older adults	11
Editorial Advisory Board	11
Hippocampal and non-hippocampal correlates of physically active lifestyle and their relation to episodic memory in older adults	11
Structural volume and cortical thickness differences between males and females in cognitively normal, cognitively impaired and Alzheimer’s dementia population	11
Association of longitudinal cognitive decline with diffusion MRI in Gray Matter, Amyloid, and Tau deposition	11
Increased regional white matter hyperintensity volume in objectively-defined subtle cognitive decline and mild cognitive impairment	11
Amyloid, cerebrovascular disease, and neurodegeneration biomarkers are associated with cognitive trajectories in a racially and ethnically diverse, community-based sample	11
Plasma neurofilament light as blood marker for poor brain white matter integrity among middle-aged urban adults	11
Advanced brain age in community-dwelling population with combined physical and cognitive impairments	11
Retraction notice to “Age-related declines in neural selectivity manifest differentially during encoding and recognition” [Neurobiology of Aging Volume 112, April 2022, Page 139–150]	11
Associations of cerebrovascular disease and Alzheimer’s disease pathology with cognitive decline: Analysis of the National Alzheimer’s Coordinating Center Uniform Data Set	11
Age-related similarities and differences in cognitive and neural processing revealed by task-related microstate analysis	10
CRYAB plays a role in terminating the presence of pro-inflammatory macrophages in the older, injured mouse peripheral nervous system	10
Age-related ultrastructural changes in the lateral cortex of the inferior colliculus	10
The association between control of interference and white-matter integrity: A cross-sectional and longitudinal investigation	10
The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer's disease mouse model	10
Lifespan longitudinal changes in mesocortical thickness and executive function: Role of dopaminergic genetic predisposition	10
Lack of PTRHD1 mutation in patients with young-onset and familial Parkinson’s disease in a Taiwanese population	10
A ketogenic intervention improves dorsal attention network functional and structural connectivity in mild cognitive impairment	10
Associations of physical function and body mass index with functional brain networks in community-dwelling older adults	10
Spectral power ratio as a measure of EEG changes in mild cognitive impairment due to Alzheimer’s disease: a case-control study	10
Age-related differences in ERP correlates of value-based decision making	10
Alpha desynchronization during Stroop test unmasks cognitively healthy individuals with abnormal CSF Amyloid/Tau	10
Low-frequency and rare coding variants of NUS1 contribute to susceptibility and phenotype of Parkinson's disease	10
Lack of association of TP73 with amyotrophic lateral sclerosis in a large cohort of cases	10
Aging-induced microbleeds of the mouse thalamus compared to sensorimotor and memory defects	10
Comparison of age-related declines in behavioral auditory responses versus electrophysiological measures of amplitude modulation	10
Mutation screening and burden analysis of GLT8D1 in Chinese patients with amyotrophic lateral sclerosis	10
Association of peripheral immunity and cerebral small vessel disease in older adults without dementia: A longitudinal study	10
The TgF344-AD rat: behavioral and proteomic changes associated with aging and protein expression in a transgenic rat model of Alzheimer's disease	10
Frontoparietal function and underlying structure reflect capacity for motor skill acquisition during healthy aging	10
Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques	10
Resistance to developing brain pathology due to vascular risk factors: the role of educational attainment	10
CSF phosphorylated tau as an indicator of subsequent tau accumulation	10
Association of the CD2AP locus with cognitive functioning among middle-aged individuals with a family history of Alzheimer's disease	10
Age-related ultrastructural neurovascular changes in the female mouse cortex and hippocampus	10
Low-moderate dose whole-brain γ-ray irradiation modulates the expressions of glial fibrillary acidic protein and intercellular adhesion molecule-1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine–i	10