Medicinal Research Reviews

Article	Citations
	170
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	147
New drug approvals for 2022: Synthesis and clinical applications	142
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Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	130
Key characters of glycodrugs	112
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	98
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	96
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	91
Galectin‐8 inhibition and functions in immune response and tumor biology	88
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	87
Front Cover Image, Volume 45, Issue 1	82
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	77
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	68
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	68
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	67
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	64
Current and emerging approaches to noncompetitive AR inhibition	64
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	63
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	63
Association predictions of genomics, proteinomics, transcriptomics, microbiome, metabolomics, pathomics, radiomics, drug, symptoms, environment factor, and disease networks: A comprehensive approach	59
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	56
Mitochondrial quality control proteases and their modulation for cancer therapy	53
Enhancing healthy aging with small molecules: A mitochondrial perspective	52
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	51

α‐Synuclein in Parkinson's Disease: From Bench to Bedside	49
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	47
Emerging roles of nerve‐bone axis in modulating skeletal system	47
Current nanocomposite advances for biomedical and environmental application diversity	46
Issue Information	43
Issue Information	42
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	39
The role of Wnt signaling in skin fibrosis	38
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	36
Targeting epigenetic modifications in Parkinson's disease therapy	35
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	34
Inside Front Cover Image, Volume 44, Issue 5	34
LSD1 in drug discovery: From biological function to clinical application	33
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	33
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Advances in reversible covalent kinase inhibitors	32
An overview of the progress made in research into the Mpox virus	32
ER stress and inflammation crosstalk in obesity	31
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	31
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	30
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	29
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	27
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	26
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Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	25
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	25
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	25
Cardiovascular therapeutics: A new potential for anxiety treatment?	25
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	25
The following articles for this Special Issue were published before this collection was released. They can be found in their respective issues or online.	25
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	25
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	24
Computational benchmarking of putative KIFC1 inhibitors	24
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Chemistry and biological activity of resin glycosides from Convolvulaceae species	23
Harnessing the Power of Natural Products for Targeted Protein Degradation	23
H+‐slip correlated to rotor free‐wheeling as cause of F1FO‐ATPase dysfunction in primary mitochondrial disorders	22
Issue Information	22
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	21
Front Cover Image, Volume 45, Issue 4	21
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Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	21
Issue Information	20
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	20
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	20
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	20
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Genetically modified cancer vaccines: Current status and future prospects	20

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Recent Developments in the Optical Control of Adrenergic Signaling	19
Advances in machine intelligence‐driven virtual screening approaches for big‐data	19
In honor of Professor Youyou Tu on the occasion of her 90th birthday	18
Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy	18
Comprehensive Insights Into Sulfanilamido‐Based Medicinal Design and Research	18
Incomplete autophagy: Trouble is a friend	17
Poly (adenosine diphosphate‐ribose) polymerase inhibitors in the treatment of triple‐negative breast cancer with homologous repair deficiency	17
The lymphatic vasculature: An active and dynamic player in cancer progression	17
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Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?	17
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Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy	17
Issue Information	16
Unleashing the Power of Covalent Drugs for Protein Degradation	16
Small‐molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria‐related diseases	16
Biofabrication approaches and regulatory framework of metastatic tumor‐on‐a‐chip models for precision oncology	16
Cuproptosis: Mechanism, role, and advances in urological malignancies	16
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies	15
Cutting‐Edge Therapy and Immune Escape Mechanisms in EBV‐Associated Tumors	15
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections	15
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands	15
Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition	15
Epigenetic modifications in pancreas development, diabetes, and therapeutics	15
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders	15
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1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives	14
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions	14
The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis	14
Chemo‐proteomics in antimalarial target identification and engagement	13
Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport	13
Extracellular vesicles: Emerging frontiers in wound healing	12
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution	12
Issue Information	12
Issue Information	12
Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update	12
Lipidomic landscape in cancer: Actionable insights for membrane‐based therapy and diagnoses	12
Unrevealing the connection between real sample analysis and analytical method. The case of cytokines	12
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The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management	12
Issue Information	12
Front Cover Image, Volume 44, Issue 5	12
Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective	11
Recent Progress in Azobenzene‐Based In Vivo Photopharmacology	11
Issue Information	11
Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective	11
Pyroptosis and the fight against lung cancer	11
The Current Progress in the Quest for Vaccines Against the Semliki Forest Virus Complex	11
Artemisinins: Promising drug candidates for the treatment of autoimmune diseases	11
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease	11
Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets	11
Mechanism of activation and the rewired network: New drug design concepts	10
The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications	10
Issue Information	10
The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer	10
Parkin exerts the tumor‐suppressive effect through targeting mitochondria	10
Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin	10
Therapeutic Potential of Vascular Adhesion Protein‐1 (VAP‐1)/Semicarbazide‐Sensitive Amine Oxidase (SSAO) Inhibitors: Current Medicinal Chemistry and Emerging Opportunities	10
Bacterial proton motive force as an unprecedented target to control antimicrobial resistance	9
How Artificial Intelligence Assists in Overcoming Drug Resistance?	9
Application or function of citric acid in drug delivery platforms	9
The recent advance and prospect of poly(ADP‐ribose) polymerase inhibitors for the treatment of cancer	9
Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases	9
Progress in RAS‐targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras	9
Revolutionizing the battle against locally advanced breast cancer: A comprehensive insight into neoadjuvant radiotherapy	9
Issue Information	9
Beyond dopamine: Novel strategies for schizophrenia treatment	9
Advanced models for respiratory disease and drug studies	9
Front Cover Image, Volume 43, Issue 6	8
Progress and perspective on hydrogen sulfide donors and their biomedical applications	8
Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates	8
Back Cover Image, Volume 41, Issue 6	7
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Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy	7
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Estrogen deficiency‐mediated osteoimmunity in postmenopausal osteoporosis	7
Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases	7
Activation and inhibition of sirtuins: From bench to bedside	7
Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders	7

β3‐Adrenoceptor, a novel player in the round‐trip from neonatal diseases to cancer: Suggestive clues from embryo	7
Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies	7