Medicinal Research Reviews

Article	Citations
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Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	149
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	125
Natural products as Zika antivirals	117
New drug approvals for 2022: Synthesis and clinical applications	116
Front Cover Image, Volume 44, Issue 4	104
Bivalent and bitopic ligands of the opioid receptors: The prospects of a dual approach	99
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	90
Front Cover Image, Volume 41, Issue 4	90
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	80
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies	79
Skin cancer, including related pathways and therapy and the role of luteolin derivatives as potential therapeutics	76
Counter‐intuitive discovery in the formulation of poorly water‐soluble drugs: Amorphous small‐molecule gels	72
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands	71
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	66
Front Cover Image, Volume 43, Issue 4	60
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	59
β3‐Adrenoceptor, a novel player in the round‐trip from neonatal diseases to cancer: Suggestive clues from embryo	58
Molecular mechanism(s) of regulations of cancer stem cell in brain cancer propagation	57
Emerging potentials of Fe‐based nanomaterials for chiral sensing and imaging	56
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Upgrade of an old drug: Auranofin in innovative cancer therapies to overcome drug resistance and to increase drug effectiveness	49
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The following articles for this Special Issue were published before this collection was released. They can be found in their respective issues or online.	46
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Front Cover Image, Volume 41, Issue 6	45
The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases	40
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Key characters of glycodrugs	37
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Energy Metabolism Supports Molecular and Functional Heterogeneity of Reactive Astrocytes in Central Nervous System Disorders	36
Cutting‐Edge Therapy and Immune Escape Mechanisms in EBV‐Associated Tumors	36
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	35
Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies	34
Connecting the dots: Targeting the microbiome in drug toxicity	33
Estrogen deficiency‐mediated osteoimmunity in postmenopausal osteoporosis	32
Autosomic dominant polycystic kidney disease and metformin: Old knowledge and new insights on retarding progression of chronic kidney disease	31
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections	31
Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy	31
Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling	30
Dissecting the pleiotropic roles of reactive oxygen species (ROS) in lung cancer: From carcinogenesis toward therapy	30
Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases	30
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	29
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders	29
The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases	29
Galectin‐8 inhibition and functions in immune response and tumor biology	28
Front Cover Image, Volume 41, Issue 3	28
Recent advances in the development of allosteric protein tyrosine phosphatase inhibitors for drug discovery	28
Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition	28
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The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management	24
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Preclinical evidence using synthetic compounds and natural products indicates that AMPK represents a potential pharmacological target for the therapy of pulmonary diseases	23
Recent insights in the PI3K/Akt pathway as a promising therapeutic target in combination with EGFR‐targeting agents to treat head and neck squamous cell carcinoma	23
Elimination of the hepatitis B virus: A goal, a challenge	23
Analyzing the scaffold diversity of cyclin‐dependent kinase inhibitors and revisiting the clinical and preclinical pipeline	23
Lipidomic landscape in cancer: Actionable insights for membrane‐based therapy and diagnoses	22
Neuroprotective, neurogenic, and anticholinergic evidence ofGanoderma lucidumcognitive effects: Crucial knowledge is still lacking	22
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	22
Inside Front Cover Image, Volume 44, Issue 2	21
Applications of medicinal chemistry for drug discovery against Acanthamoeba infections	20
Cardiovascular therapeutics: A new potential for anxiety treatment?	20
Front Cover Image, Volume 44, Issue 6	20
A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection	20
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	20
Purinergic receptors modulators: An emerging pharmacological tool for disease management	19
Current and emerging approaches to noncompetitive AR inhibition	19
Unveiling gut microbiota's role: Bidirectional regulation of drug transport for improved safety	19
1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives	19

Inside Front Cover Image, Volume 41, Issue 3	18
Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment	18
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution	18
Human mpox: Biology, epidemiology, therapeutic options, and development of small molecule inhibitors	18
GADD45A: With or without you	17
Front Cover Image, Volume 45, Issue 1	17
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	17
Dual‐target inhibitors of bromodomain and extra‐terminal proteins in cancer: A review from medicinal chemistry perspectives	16
Targeting tumor microenvironment with photodynamic nanomedicine	16
Corrigendum: Molecular targeting therapies for neuroblastoma: Progress and challenges	16
Fast and furious: The neutrophil and its armamentarium in health and disease	15
Chemistry and biological activity of resin glycosides from Convolvulaceae species	15
Histone deacetylase‐based dual targeted inhibition in multiple myeloma	15
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	15
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	15
Perspectives on pain in Down syndrome	15
Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review	14
Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport	14
Biologically active secoiridoids: A comprehensive update	14
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions	14
Insights into Ganoderma fungi meroterpenoids opening a new era of racemic natural products in mushrooms	14
Trends in targeted delivery of nanomaterials in colon cancer diagnosis and treatment	14
Computational benchmarking of putative KIFC1 inhibitors	14
The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis	13
The new direction of drug development: Degradation of undruggable targets through targeting chimera technology	13
Bioactive atropisomers: Unraveling design strategies and synthetic routes for drug discovery	13
(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy	13
Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update	12
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	12
Extracellular vesicles: Emerging frontiers in wound healing	12
Metabolomics as a tool for the early diagnosis and prognosis of diabetic kidney disease	12
Fluorescent imaging probes for in vivo ovarian cancer targeted detection and surgery	11
Issue Information	11
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	11
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Chemo‐proteomics in antimalarial target identification and engagement	11
Back Cover Image, Volume 41, Issue 3	10
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The following articles for this Special Issue were published before this collection was released. They can be found in their respective issues or online.	10
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B‐cell lymphoma‐2 family proteins in the crosshairs: Small molecule inhibitors and activators for cancer therapy	9
H+‐slip correlated to rotor free‐wheeling as cause of F1FO‐ATPase dysfunction in primary mitochondrial disorders	9
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Front Cover Image, Volume 42, Issue 3	9
Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective	9
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease	9
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Inside Front Cover Image, Volume 41, Issue 4	9
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Recent advances in the adjunctive management of diabetic foot ulcer: Focus on noninvasive technologies	8
Unrevealing the connection between real sample analysis and analytical method. The case of cytokines	8
Leveraging the ATP‐P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications	8
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	8
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	8
Front Cover Image, Volume 42, Issue 4	8
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	8
Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future	8
Artemisinins: Promising drug candidates for the treatment of autoimmune diseases	8
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	8
Pyroptosis and the fight against lung cancer	8
Front Cover Image, Volume 44, Issue 5	8
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	8
Genetically modified cancer vaccines: Current status and future prospects	8
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	8
Enhancing healthy aging with small molecules: A mitochondrial perspective	7
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	7
Therapeutic potential of salicylamide derivatives for combating viral infections	7
Engineering peptide drug therapeutics through chemical conjugation and implication in clinics	7
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	7
Mesenchymal stromal cell therapy for pancreatitis: Progress and challenges	7
Association predictions of genomics, proteinomics, transcriptomics, microbiome, metabolomics, pathomics, radiomics, drug, symptoms, environment factor, and disease networks: A comprehensive approach	6
Targeting the HSP90–CDC37–kinase chaperone cycle: A promising therapeutic strategy for cancer	6
Light‐Activated Pharmacological Tools for Exploring the Cholinergic System	6
Mitochondrial quality control proteases and their modulation for cancer therapy	6

Emerging roles of nerve‐bone axis in modulating skeletal system	6
Inflammatory bowel disease biomarkers	6
A review in radiomics: Making personalized medicine a reality via routine imaging	6
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	6
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	6
Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective	6