Medicinal Research Reviews

Papers
(The median citation count of Medicinal Research Reviews is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)
ArticleCitations
203
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Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy169
Key characters of glycodrugs144
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery128
New drug approvals for 2022: Synthesis and clinical applications119
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders116
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment107
The role and prospect of lysine‐specific demethylases in cancer chemoresistance89
Galectin‐8 inhibition and functions in immune response and tumor biology88
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers88
Front Cover Image, Volume 45, Issue 181
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Current and emerging approaches to noncompetitive AR inhibition76
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses75
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents73
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel71
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders67
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer66
Enhancing healthy aging with small molecules: A mitochondrial perspective65
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing65
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review64
Current nanocomposite advances for biomedical and environmental application diversity58
α‐Synuclein in Parkinson's Disease: From Bench to Bedside52
Mitochondrial quality control proteases and their modulation for cancer therapy47
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases46
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators42
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases42
Emerging roles of nerve‐bone axis in modulating skeletal system40
Issue Information39
Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy37
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis36
Human Cyclophilins—An Emerging Class of Drug Targets35
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds35
An overview of the progress made in research into the Mpox virus34
Inside Front Cover Image, Volume 44, Issue 534
Advances in reversible covalent kinase inhibitors34
LSD1 in drug discovery: From biological function to clinical application33
Targeting epigenetic modifications in Parkinson's disease therapy33
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future31
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis31
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment30
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives29
HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases29
ER stress and inflammation crosstalk in obesity28
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Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects28
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery28
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Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications27
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Kinin B 1 and B 2 Receptors: Role in Tumor Progression and Pain Associated With Tumor and Anticanc27
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents27
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The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches27
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands27
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography26
Computational benchmarking of putative KIFC1 inhibitors26
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide26
Cardiovascular therapeutics: A new potential for anxiety treatment?26
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics25
Harnessing the Power of Natural Products for Targeted Protein Degradation25
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage24
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity24
Chemistry and biological activity of resin glycosides from Convolvulaceae species23
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A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications22
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective22
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology22
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Front Cover Image, Volume 45, Issue 422
Medicinal Chemistry Strategies for the Development of CD73 Inhibitors in Cancer Immunotherapy21
H+‐slip correlated to rotor free‐wheeling as cause of F1FO‐ATPase dysfunction in primary mitochondrial disorders21
Genetically modified cancer vaccines: Current status and future prospects21
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development20
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Issue Information20
Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy20
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential20
Comprehensive Insights Into Sulfanilamido‐Based Medicinal Design and Research19
Advances in machine intelligence‐driven virtual screening approaches for big‐data19
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Recent Developments in the Optical Control of Adrenergic Signaling18
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Incomplete autophagy: Trouble is a friend18
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Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?18
Cuproptosis: Mechanism, role, and advances in urological malignancies17
Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy17
Small‐molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria‐related diseases17
Issue Information16
Biofabrication approaches and regulatory framework of metastatic tumor‐on‐a‐chip models for precision oncology16
Poly (adenosine diphosphate‐ribose) polymerase inhibitors in the treatment of triple‐negative breast cancer with homologous repair deficiency16
Near‐Infrared Fluorescent Probe for the Early Diagnosis of Alzheimer's Disease16
Unleashing the Power of Covalent Drugs for Protein Degradation15
Epigenetic modifications in pancreas development, diabetes, and therapeutics15
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands15
Covalent Bifunctional Molecules (CBMs): Achievements and Challenges15
Cutting‐Edge Therapy and Immune Escape Mechanisms in EBV‐Associated Tumors15
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders15
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies15
Chemo‐proteomics in antimalarial target identification and engagement14
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Extracellular vesicles: Emerging frontiers in wound healing14
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution14
1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives14
The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis14
The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management14
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections14
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions14
Front Cover Image, Volume 44, Issue 513
Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport13
Unrevealing the connection between real sample analysis and analytical method. The case of cytokines13
Pyroptosis and the fight against lung cancer13
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Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective13
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Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective13
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease12
Parkin exerts the tumor‐suppressive effect through targeting mitochondria12
Artemisinins: Promising drug candidates for the treatment of autoimmune diseases12
Therapeutic Potential of Vascular Adhesion Protein‐1 (VAP‐1)/Semicarbazide‐Sensitive Amine Oxidase (SSAO) Inhibitors: Current Medicinal Chemistry and Emerging Opportunities12
The Current Progress in the Quest for Vaccines Against the Semliki Forest Virus Complex12
Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets12
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Recent Progress in Azobenzene‐Based In Vivo Photopharmacology12
The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications11
Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin11
Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases11
The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer11
How Artificial Intelligence Assists in Overcoming Drug Resistance?10
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Advanced models for respiratory disease and drug studies10
Bacterial proton motive force as an unprecedented target to control antimicrobial resistance10
Revolutionizing the battle against locally advanced breast cancer: A comprehensive insight into neoadjuvant radiotherapy10
Progress and perspective on hydrogen sulfide donors and their biomedical applications10
Progress in RAS‐targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras10
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management9
The recent advance and prospect of poly(ADP‐ribose) polymerase inhibitors for the treatment of cancer9
Activation and inhibition of sirtuins: From bench to bedside9
Beyond dopamine: Novel strategies for schizophrenia treatment9
Recent advances in dopamine D2 receptor ligands in the treatment of neuropsychiatric disorders9
Front Cover Image, Volume 43, Issue 69
Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates9
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The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications8
Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy8
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