OOIR: Observatory of International Research

Papers

(The median citation count of Medicinal Research Reviews is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
	229
	211
Key characters of glycodrugs	195
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	171
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	147
Galectin‐8 inhibition and functions in immune response and tumor biology	145
In Memoriam: Professor Minyong Li (1976–2025)	116
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	115
Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns	110
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	95
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	91
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	87
Accelerating Small Molecule Ferroptosis Regulator Development With Advances in Biological Functions	84
New drug approvals for 2022: Synthesis and clinical applications	83
Front Cover Image, Volume 45, Issue 1	82
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses	81
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Issue Information	80
Current and emerging approaches to noncompetitive AR inhibition	77
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	74
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	65
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	63
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	63
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	47
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	46

Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	43
Mitochondrial quality control proteases and their modulation for cancer therapy	42
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	42
Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery	41
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	39
Current nanocomposite advances for biomedical and environmental application diversity	39
Enhancing healthy aging with small molecules: A mitochondrial perspective	39
Emerging roles of nerve‐bone axis in modulating skeletal system	39
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	37
Issue Information	37
Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy	36
Human Cyclophilins—An Emerging Class of Drug Targets	36
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	36
LSD1 in drug discovery: From biological function to clinical application	33
Advances in reversible covalent kinase inhibitors	33
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	33
An overview of the progress made in research into the Mpox virus	33
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	33
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	33
Inside Front Cover Image, Volume 44, Issue 5	33
Targeting epigenetic modifications in Parkinson's disease therapy	32
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	32
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	32
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	32
HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases	31
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	31
	31
ER stress and inflammation crosstalk in obesity	31
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Issue Information	30
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The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches	29
Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications	29
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	28
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	28
Kinin B ₁ and B ₂ Receptors: Role in Tumor Progression and Pain Associated With Tumor and Anticanc	28
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	27
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	27
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	26
Harnessing the Power of Natural Products for Targeted Protein Degradation	25
Chemistry and biological activity of resin glycosides from Convolvulaceae species	25
Computational benchmarking of putative KIFC1 inhibitors	25
Issue Information	24
	24
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	24
	24
Front Cover Image, Volume 45, Issue 4	23
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	23
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	22
H+‐slip correlated to rotor free‐wheeling as cause of F₁F_O‐ATPase dysfunction in primary mitochondrial disorders	22

A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	22
Tirzepatide in Metabolic Diseases: Clinical Efficacy and Safety Beyond Diabetes and Obesity	22
Medicinal Chemistry Strategies for the Development of CD73 Inhibitors in Cancer Immunotherapy	22
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	22
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Issue Information	21
Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy	21
	21
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	21
Recent Developments in the Optical Control of Adrenergic Signaling	21
	21
Cuproptosis: Mechanism, role, and advances in urological malignancies	20
	20
Advances in machine intelligence‐driven virtual screening approaches for big‐data	20
Comprehensive Insights Into Sulfanilamido‐Based Medicinal Design and Research	20
Issue Information	19
Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?	19
Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy	19
Small‐molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria‐related diseases	19
Poly (adenosine diphosphate‐ribose) polymerase inhibitors in the treatment of triple‐negative breast cancer with homologous repair deficiency	19
Biofabrication approaches and regulatory framework of metastatic tumor‐on‐a‐chip models for precision oncology	18
Cutting‐Edge Therapy and Immune Escape Mechanisms in EBV‐Associated Tumors	18
Mucin O‐Glycosylation and Mucolytic Therapies in Pseudomyxoma Peritonei: Literature Review	18
Unleashing the Power of Covalent Drugs for Protein Degradation	18
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders	18
	18
Covalent Bifunctional Molecules (CBMs): Achievements and Challenges	18
Near‐Infrared Fluorescent Probe for the Early Diagnosis of Alzheimer's Disease	18
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies	17
Recent Advances of Non‐Nucleoside Polymerase Inhibitors With Broad‐Spectrum Antiviral Activities	17
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands	17
The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis	16
	16
The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management	16
Chemo‐proteomics in antimalarial target identification and engagement	16
Extracellular vesicles: Emerging frontiers in wound healing	16
1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives	16
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution	15
Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport	15
Issue Information	15
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions	15
	15
Front Cover Image, Volume 44, Issue 5	15
Issue Information	15
Issue Information	14
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease	14
Issue Information	14
Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective	14
Pyroptosis and the fight against lung cancer	14
Issue Information	14
Unrevealing the connection between real sample analysis and analytical method. The case of cytokines	14
Issue Information	13
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?	13
Recent Progress in Azobenzene‐Based In Vivo Photopharmacology	13
The Current Progress in the Quest for Vaccines Against the Semliki Forest Virus Complex	13
Artemisinins: Promising drug candidates for the treatment of autoimmune diseases	13
The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer	12
Therapeutic Potential of Vascular Adhesion Protein‐1 (VAP‐1)/Semicarbazide‐Sensitive Amine Oxidase (SSAO) Inhibitors: Current Medicinal Chemistry and Emerging Opportunities	12
Issue Information	12
Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases	12
Parkin exerts the tumor‐suppressive effect through targeting mitochondria	12
The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications	12
Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin	11
Progress in RAS‐targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras	11
Bacterial proton motive force as an unprecedented target to control antimicrobial resistance	11
Issue Information	11
Immunosuppressive Tumor Microenvironment and Therapeutic Landscape of Diffuse Intrinsic Pontine Glioma	10
Progress and perspective on hydrogen sulfide donors and their biomedical applications	10
How Artificial Intelligence Assists in Overcoming Drug Resistance?	10
Revolutionizing the battle against locally advanced breast cancer: A comprehensive insight into neoadjuvant radiotherapy	10
Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates	10
The recent advance and prospect of poly(ADP‐ribose) polymerase inhibitors for the treatment of cancer	10
Advanced models for respiratory disease and drug studies	10
Beyond dopamine: Novel strategies for schizophrenia treatment	10
Activation and inhibition of sirtuins: From bench to bedside	9
Recent advances in dopamine D₂ receptor ligands in the treatment of neuropsychiatric disorders	9
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management	9
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Front Cover Image, Volume 43, Issue 6	9