OOIR: Observatory of International Research

Papers

(The median citation count of Medicinal Research Reviews is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
	193
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	163
New drug approvals for 2022: Synthesis and clinical applications	137
	130
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	127
Galectin‐8 inhibition and functions in immune response and tumor biology	123
Key characters of glycodrugs	120
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	98
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	92
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	85
Issue Information	84
Current and emerging approaches to noncompetitive AR inhibition	83
Front Cover Image, Volume 45, Issue 1	73
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	72
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	71
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	65
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	63
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	61
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	60
Inside Front Cover Image, Volume 41, Issue 4	60
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	58
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	58
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	55
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	55
Mitochondrial quality control proteases and their modulation for cancer therapy	48

Emerging roles of nerve‐bone axis in modulating skeletal system	48
Current nanocomposite advances for biomedical and environmental application diversity	46
Enhancing healthy aging with small molecules: A mitochondrial perspective	46
Association predictions of genomics, proteinomics, transcriptomics, microbiome, metabolomics, pathomics, radiomics, drug, symptoms, environment factor, and disease networks: A comprehensive approach	43
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	42
Issue Information	41
Issue Information	41
The role of Wnt signaling in skin fibrosis	37
Inside Front Cover Image, Volume 44, Issue 5	37
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	37
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	37
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	36
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	34
LSD1 in drug discovery: From biological function to clinical application	33
Advances in reversible covalent kinase inhibitors	33
An overview of the progress made in research into the Mpox virus	32
	31
Recent pharmacological advances in the repurposing of artemisinin drugs	31
Targeting epigenetic modifications in Parkinson's disease therapy	31
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	31
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	30
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	30
Artemisinin‐derived dimers from a chemical perspective	29
ER stress and inflammation crosstalk in obesity	29
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	27
The following articles for this Special Issue were published before this collection was released. They can be found in their respective issues or online.	26
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Corrigendum: Molecular targeting therapies for neuroblastoma: Progress and challenges	23
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	23
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	23
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	23
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	23
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	23
Harnessing the Power of Natural Products for Targeted Protein Degradation	22
Cardiovascular therapeutics: A new potential for anxiety treatment?	22
Computational benchmarking of putative KIFC1 inhibitors	22
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	21
Chemistry and biological activity of resin glycosides from Convolvulaceae species	21
	21
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	21
Issue Information	21
H+‐slip correlated to rotor free‐wheeling as cause of F₁F_O‐ATPase dysfunction in primary mitochondrial disorders	20
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	20
	19
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	19
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	19
Genetically modified cancer vaccines: Current status and future prospects	19
Issue Information	18

	18
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	18
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	18
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Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy	17
	17
In honor of Professor Youyou Tu on the occasion of her 90th birthday	16
Incomplete autophagy: Trouble is a friend	16
Recent Developments in the Optical Control of Adrenergic Signaling	16
Advances in machine intelligence‐driven virtual screening approaches for big‐data	16
Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?	15
	15
Small‐molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria‐related diseases	15
Biofabrication approaches and regulatory framework of metastatic tumor‐on‐a‐chip models for precision oncology	15
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Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy	15
The lymphatic vasculature: An active and dynamic player in cancer progression	15
Structural insights into the distinctive RNA recognition and therapeutic potentials of RIG‐I‐like receptors	15
Poly (adenosine diphosphate‐ribose) polymerase inhibitors in the treatment of triple‐negative breast cancer with homologous repair deficiency	15
Cuproptosis: Mechanism, role, and advances in urological malignancies	15
Issue Information	15
Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition	14
Cutting‐Edge Therapy and Immune Escape Mechanisms in EBV‐Associated Tumors	14
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands	14
Unleashing the Power of Covalent Drugs for Protein Degradation	14
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies	14
Epigenetic modifications in pancreas development, diabetes, and therapeutics	14
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders	13
The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management	12
1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives	12
Autosomic dominant polycystic kidney disease and metformin: Old knowledge and new insights on retarding progression of chronic kidney disease	12
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions	12
	12
Lipidomic landscape in cancer: Actionable insights for membrane‐based therapy and diagnoses	12
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections	12
The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution	11
Extracellular vesicles: Emerging frontiers in wound healing	11
	11
Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update	11
Chemo‐proteomics in antimalarial target identification and engagement	11
Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport	11
The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis	11
Issue Information	11
Issue Information	11
Front Cover Image, Volume 44, Issue 5	10
Artemisinins: Promising drug candidates for the treatment of autoimmune diseases	10
Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets	10
Issue Information	10
Recent Progress in Azobenzene‐Based In Vivo Photopharmacology	10
Molecular mechanisms and therapeutic perspectives of peroxisome proliferator‐activated receptor α agonists in cardiovascular health and disease	10
Unrevealing the connection between real sample analysis and analytical method. The case of cytokines	10
Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective	10
Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective	10
Pyroptosis and the fight against lung cancer	10
The antisickling agent, 5‐hydroxymethyl‐2‐furfural: Other potential pharmacological applications	9
Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases	9
A review in radiomics: Making personalized medicine a reality via routine imaging	9
Parkin exerts the tumor‐suppressive effect through targeting mitochondria	9
Combining stem cells in myocardial infarction: The road to superior repair?	9
Mechanism of activation and the rewired network: New drug design concepts	9
Issue Information	9
Modulation of neurotrophic factors in the treatment of dementia, stroke and TBI: Effects of Cerebrolysin	9
Bacterial proton motive force as an unprecedented target to control antimicrobial resistance	9
The Current Progress in the Quest for Vaccines Against the Semliki Forest Virus Complex	9
Advanced models for respiratory disease and drug studies	8
Issue Information	8
The recent advance and prospect of poly(ADP‐ribose) polymerase inhibitors for the treatment of cancer	8
The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer	8
Progress in RAS‐targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras	8
Therapeutic Potential of Vascular Adhesion Protein‐1 (VAP‐1)/Semicarbazide‐Sensitive Amine Oxidase (SSAO) Inhibitors: Current Medicinal Chemistry and Emerging Opportunities	8
Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates	7
Progress and perspective on hydrogen sulfide donors and their biomedical applications	7
Back Cover Image, Volume 41, Issue 6	7
Application or function of citric acid in drug delivery platforms	7
Beyond dopamine: Novel strategies for schizophrenia treatment	7
Front Cover Image, Volume 43, Issue 6	7
Revolutionizing the battle against locally advanced breast cancer: A comprehensive insight into neoadjuvant radiotherapy	7
	7
Activation and inhibition of sirtuins: From bench to bedside	7