OOIR: Observatory of International Research

Papers

(The TQCC of Medicinal Research Reviews is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
	244
	216
In Memoriam: Professor Minyong Li (1976–2025)	197
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	174
Key characters of glycodrugs	153
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	123
New drug approvals for 2022: Synthesis and clinical applications	118
Accelerating Small Molecule Ferroptosis Regulator Development With Advances in Biological Functions	113
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	96
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	96
Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns	92
Galectin‐8 inhibition and functions in immune response and tumor biology	91
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	90
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria	85
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	84
	83
Front Cover Image, Volume 45, Issue 1	83
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	77
Current and emerging approaches to noncompetitive AR inhibition	77
Issue Information	65
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	65
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	65
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	50
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses	47
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	44

The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	43
Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery	43
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	43
Current nanocomposite advances for biomedical and environmental application diversity	40
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	40
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	40
Mitochondrial quality control proteases and their modulation for cancer therapy	40
Emerging roles of nerve‐bone axis in modulating skeletal system	39
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	37
Enhancing healthy aging with small molecules: A mitochondrial perspective	37
A Possibility of Synthetic Lethality: Wee1 Kinase as a Promising Treating Target for Cancer	37
Issue Information	36
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	36
Human Cyclophilins—An Emerging Class of Drug Targets	35
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	35
Inside Front Cover Image, Volume 44, Issue 5	34
Designing the Next Generation of Antibiotics: Structure, SAR, and Strategy in Medicinal Chemistry (2000–2025)	34
An overview of the progress made in research into the Mpox virus	34
Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy	34
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	33
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	33
Targeting epigenetic modifications in Parkinson's disease therapy	33
Advances in reversible covalent kinase inhibitors	32
LSD1 in drug discovery: From biological function to clinical application	32
HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases	31
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	31
ER stress and inflammation crosstalk in obesity	30
Issue Information	29
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	29
	29
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	29
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	29
	28
	28
The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches	28
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	27
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	27
Kinin B ₁ and B ₂ Receptors: Role in Tumor Progression and Pain Associated With Tumor and Anticanc	26
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	26
Astatine‐211—Towards In Vivo Stable Astatine‐211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications	25
Quantification of ¹⁰ B and ¹¹ B in Biological Samples in Translational Science and Clinical Applic	25
Computational benchmarking of putative KIFC1 inhibitors	25
Chemistry and biological activity of resin glycosides from Convolvulaceae species	24
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	23
Harnessing the Power of Natural Products for Targeted Protein Degradation	23
	23
Issue Information	23
Front Cover Image, Volume 45, Issue 4	23
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	23
	23

A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	23
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	22
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	22
Targeting ClpP Protease: Emerging Therapeutic Strategies and Small‐Molecule Modulators in Drug Discovery	22
Medicinal Chemistry Strategies for the Development of CD73 Inhibitors in Cancer Immunotherapy	22
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	22