OOIR: Observatory of International Research

Papers

(The TQCC of Medicinal Research Reviews is 20. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
	174
	153
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	153
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	146
Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy	139
Galectin‐8 inhibition and functions in immune response and tumor biology	118
	103
Key characters of glycodrugs	101
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	95
New drug approvals for 2022: Synthesis and clinical applications	94
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	84
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	79
Front Cover Image, Volume 45, Issue 1	71
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	70
Current and emerging approaches to noncompetitive AR inhibition	69
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses	68
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	68
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	67
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	63
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	59
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	57
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	55
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	54
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	52
Emerging roles of nerve‐bone axis in modulating skeletal system	50

Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	50
Mitochondrial quality control proteases and their modulation for cancer therapy	49
Current nanocomposite advances for biomedical and environmental application diversity	46
Enhancing healthy aging with small molecules: A mitochondrial perspective	43
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	40
Issue Information	39
Advances in reversible covalent kinase inhibitors	35
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	35
Inside Front Cover Image, Volume 44, Issue 5	35
Issue Information	35
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	35
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	34
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	34
An overview of the progress made in research into the Mpox virus	33
Targeting epigenetic modifications in Parkinson's disease therapy	32
LSD1 in drug discovery: From biological function to clinical application	31
	30
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	29
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	29
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	29
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	28
ER stress and inflammation crosstalk in obesity	27
	27
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	26
	26
	26
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	25
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	25
Issue Information	25
Cardiovascular therapeutics: A new potential for anxiety treatment?	24
Chemistry and biological activity of resin glycosides from Convolvulaceae species	24
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	24
Harnessing the Power of Natural Products for Targeted Protein Degradation	24
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	24
Computational benchmarking of putative KIFC1 inhibitors	24
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	23
Issue Information	23
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	23
	23
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	22
H+‐slip correlated to rotor free‐wheeling as cause of F₁F_O‐ATPase dysfunction in primary mitochondrial disorders	22
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	22
	22
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	22
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	22
Genetically modified cancer vaccines: Current status and future prospects	21
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	21
Front Cover Image, Volume 45, Issue 4	21
Issue Information	20
	20

Comparison of Radionuclide Drug Conjugates With Boron Neutron Capture Therapy: An Overview of Targeted Charged Particle Radiation Therapy	20
	20
In honor of Professor Youyou Tu on the occasion of her 90th birthday	20
	20
Incomplete autophagy: Trouble is a friend	20