OOIR: Observatory of International Research

Papers

(The TQCC of Medicinal Research Reviews is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
	420
	176
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	149
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	125
Natural products as Zika antivirals	117
New drug approvals for 2022: Synthesis and clinical applications	116
Front Cover Image, Volume 44, Issue 4	104
Bivalent and bitopic ligands of the opioid receptors: The prospects of a dual approach	99
Front Cover Image, Volume 41, Issue 4	90
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	90
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	80
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies	79
Skin cancer, including related pathways and therapy and the role of luteolin derivatives as potential therapeutics	76
Counter‐intuitive discovery in the formulation of poorly water‐soluble drugs: Amorphous small‐molecule gels	72
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands	71
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	66
Front Cover Image, Volume 43, Issue 4	60
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	59
β3‐Adrenoceptor, a novel player in the round‐trip from neonatal diseases to cancer: Suggestive clues from embryo	58
Molecular mechanism(s) of regulations of cancer stem cell in brain cancer propagation	57
	56
Emerging potentials of Fe‐based nanomaterials for chiral sensing and imaging	56
	54
Issue Information	52
Issue Information	51

	50
Upgrade of an old drug: Auranofin in innovative cancer therapies to overcome drug resistance and to increase drug effectiveness	49
	49
Issue Information	48
The following articles for this Special Issue were published before this collection was released. They can be found in their respective issues or online.	46
Front Cover Image, Volume 41, Issue 6	45
	45
The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases	40
Issue Information	40
	37
Key characters of glycodrugs	37
Cutting‐Edge Therapy and Immune Escape Mechanisms in EBV‐Associated Tumors	36
Energy Metabolism Supports Molecular and Functional Heterogeneity of Reactive Astrocytes in Central Nervous System Disorders	36
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	35
Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies	34
Connecting the dots: Targeting the microbiome in drug toxicity	33
Estrogen deficiency‐mediated osteoimmunity in postmenopausal osteoporosis	32
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections	31
Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy	31
Autosomic dominant polycystic kidney disease and metformin: Old knowledge and new insights on retarding progression of chronic kidney disease	31
Dissecting the pleiotropic roles of reactive oxygen species (ROS) in lung cancer: From carcinogenesis toward therapy	30
Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases	30
Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling	30
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders	29
The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases	29
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	29
Front Cover Image, Volume 41, Issue 3	28
Recent advances in the development of allosteric protein tyrosine phosphatase inhibitors for drug discovery	28
Haste makes waste: A critical review of docking‐based virtual screening in drug repurposing for SARS‐CoV‐2 main protease (M‐pro) inhibition	28
Galectin‐8 inhibition and functions in immune response and tumor biology	28
	25
Issue Information	24
The role of Toll‐like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management	24
Elimination of the hepatitis B virus: A goal, a challenge	23
Analyzing the scaffold diversity of cyclin‐dependent kinase inhibitors and revisiting the clinical and preclinical pipeline	23
Preclinical evidence using synthetic compounds and natural products indicates that AMPK represents a potential pharmacological target for the therapy of pulmonary diseases	23
Recent insights in the PI3K/Akt pathway as a promising therapeutic target in combination with EGFR‐targeting agents to treat head and neck squamous cell carcinoma	23
Neuroprotective, neurogenic, and anticholinergic evidence ofGanoderma lucidumcognitive effects: Crucial knowledge is still lacking	22
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	22
Lipidomic landscape in cancer: Actionable insights for membrane‐based therapy and diagnoses	22
Inside Front Cover Image, Volume 44, Issue 2	21
Front Cover Image, Volume 44, Issue 6	20
A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection	20
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	20
Applications of medicinal chemistry for drug discovery against Acanthamoeba infections	20
Cardiovascular therapeutics: A new potential for anxiety treatment?	20
Current and emerging approaches to noncompetitive AR inhibition	19
Unveiling gut microbiota's role: Bidirectional regulation of drug transport for improved safety	19
1,2,4,5‐Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure−activity relationship (SAR) studies and future perspectives	19
Purinergic receptors modulators: An emerging pharmacological tool for disease management	19

The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution	18
Human mpox: Biology, epidemiology, therapeutic options, and development of small molecule inhibitors	18
Inside Front Cover Image, Volume 41, Issue 3	18
Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment	18