OOIR: Observatory of International Research

Papers

(The TQCC of Medicinal Research Reviews is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
	193
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery	163
New drug approvals for 2022: Synthesis and clinical applications	137
	130
Indirect influence on the BDNF/TrkB receptor signaling pathway via GPCRs, an emerging strategy in the treatment of neurodegenerative disorders	127
Galectin‐8 inhibition and functions in immune response and tumor biology	123
Key characters of glycodrugs	120
The role and prospect of lysine‐specific demethylases in cancer chemoresistance	98
Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment	92
Nanotechnology‐based electrochemical biosensors for monitoring breast cancer biomarkers	85
Issue Information	84
Current and emerging approaches to noncompetitive AR inhibition	83
Front Cover Image, Volume 45, Issue 1	73
Metal complexes bearing EGFR‐inhibiting ligands as promising anticancer agents	72
Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel	71
Rethinking therapeutic strategies of dual‐target drugs: An update on pharmacological small‐molecule compounds in cancer	65
Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective	63
Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders	61
Inside Front Cover Image, Volume 41, Issue 4	60
The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review	60
Mechanism and application of β‐adrenoceptor blockers in soft tissue wound healing	58
α‐Synuclein in Parkinson's Disease: From Bench to Bedside	58
An overview of sphingosine‐1‐phosphate receptor 2: Structure, biological function, and small‐molecule modulators	55
Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases	55
Mitochondrial quality control proteases and their modulation for cancer therapy	48

Emerging roles of nerve‐bone axis in modulating skeletal system	48
Current nanocomposite advances for biomedical and environmental application diversity	46
Enhancing healthy aging with small molecules: A mitochondrial perspective	46
Association predictions of genomics, proteinomics, transcriptomics, microbiome, metabolomics, pathomics, radiomics, drug, symptoms, environment factor, and disease networks: A comprehensive approach	43
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases	42
Issue Information	41
Issue Information	41
The role of Wnt signaling in skin fibrosis	37
Inside Front Cover Image, Volume 44, Issue 5	37
Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis	37
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds	37
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis	36
Targeted immunotherapy and nanomedicine for rhabdomyosarcoma: The way of the future	34
LSD1 in drug discovery: From biological function to clinical application	33
Advances in reversible covalent kinase inhibitors	33
An overview of the progress made in research into the Mpox virus	32
	31
Recent pharmacological advances in the repurposing of artemisinin drugs	31
Targeting epigenetic modifications in Parkinson's disease therapy	31
CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery	31
Glutathione‐triggered prodrugs: Design strategies, potential applications, and perspectives	30
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment	30
ER stress and inflammation crosstalk in obesity	29
Artemisinin‐derived dimers from a chemical perspective	29
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects	27
The following articles for this Special Issue were published before this collection was released. They can be found in their respective issues or online.	26
	25
	25
	25
Compelling Evidence: A Critical Update on the Therapeutic Potential of Carbon Monoxide	23
Recent progress in the imaging of c‐Met aberrant cancers with positron emission tomography	23
The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents	23
A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity	23
Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands	23
Corrigendum: Molecular targeting therapies for neuroblastoma: Progress and challenges	23
Harnessing the Power of Natural Products for Targeted Protein Degradation	22
Cardiovascular therapeutics: A new potential for anxiety treatment?	22
Computational benchmarking of putative KIFC1 inhibitors	22
OGG1: An emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage	21
Chemistry and biological activity of resin glycosides from Convolvulaceae species	21
	21
Dual roles of drug or its metabolite−protein conjugate: Cutting‐edge strategy of drug discovery using shotgun proteomics	21
Issue Information	21
H+‐slip correlated to rotor free‐wheeling as cause of F₁F_O‐ATPase dysfunction in primary mitochondrial disorders	20
Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective	20
	19
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development	19
Canonical effects of cytokines on glomerulonephritis: A new outlook in nephrology	19
Genetically modified cancer vaccines: Current status and future prospects	19
	18

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential	18
A comprehensive and systemic review of ginseng‐based nanomaterials: Synthesis, targeted delivery, and biomedical applications	18
Issue Information	18