Human Immunology

Article	Citations
The changing landscape of HLA typing: Understanding how and when HLA typing data can be used with confidence from bench to bedside	594
O21 Estimating rates of immunologically incompatible organ offers caused by use of antigen-level deceased donor HLA typing for allocation	47
O35 Detection of circulating HLA-E in cancer patients: Potential application in cancer immunotherapy	45
P210 The impact of HLA-DPB1 disparity on clinical outcome post unrelated hematopoietic stem cell transplantation between 2016 and 2021 – A single center experience	44
P400 Extending a virtual crossmatch analysis and reporting workflow to include HLA eplet mismatch load with risk stratification for post transplant kidney clinical decision support	36
P221 Identifying the specificity of non-HLA antibodies in flow cytometry crossmatch positive, HLA DSA negative patient sera	36
P401 Successful removal of flow cytometry crossmatch interference by a novel rituximab biosimilar	36
P523 IgM DSA – Can they be detected before IgG DSA	35
P702 Validation of Omixon NanoTYPE HLA typing using Oxford Nanopore Technologies (ONT)	28
P2RX1-Negative neutrophils promote the immunosuppressive microenvironment in Non-Small cell lung cancer by Upregulating PD-L1 expression	27
Genomic collision at the LIMS-1 locus increases risk of cellular mediated allograft rejection in heart transplanted recipients	27
Reduction of HLA antibodies by bi-specific antibody blinatumomab	25
HLA tailored immunosuppression in living related pediatric kidney transplants in a low-income country. Cost and survival benefits	25
Concentration-dependent antibody specificity profiles of human leukocyte DQ antigens and predictions of functional epitopes	24
Endothelial derived extracellular vesicles express high level of HLA class II molecules under inflammatory conditions	24
Simplified technique sensitive washing steps for a robust hybrid capture target enrichment NGS assay	23
Novel null allele discovered by rapid next-gen sequencing	22
Changes in T helper cell-related factors in patients with type 2 diabetes mellitus after empagliflozin therapy	20
Power BI for HLA	20
Microarray analysis of autoantibodies can identify future Systemic Lupus Erythematosus patients	20
Impact of Tocilizumab treatment on the reduction of angiotensin II type 1 receptor (AT1R) antibodies	19
HLA-DR/DQ molecular mismatches for risk stratification and prediction of development of de novo donor-specific antibodies in cardiac allogeneic transplantation	19
A buccal swab DNA extraction method for Next Generation Sequencing	18
Novel HLA-A, -B, -C and -DRB1 alleles identified in the Australian New South Wales tissue typing laboratory	18
Donor specific antibodies to DQ antigens are rare in DR antigen matched kidney transplants	18

FOXP3+/CD68+ ratio within the tumor microenvironment may serve as a potential prognostic factor in classical Hodgkin lymphoma	18
Investigation of immune checkpoint molecules (CTLA-4, PD-1, PD-L1, Tim-3) expressions in preeclampsia: A comparative study of membranous and soluble forms	17
T cell senescence and impaired CMV-specific response are associated with infection risk in kidney transplant recipients	17
High fructose diet: A risk factor for immune system dysregulation	16
P403 The adsorption crossmatch cells and elution (AXE) technique to identify true HLA specific antibodies	16
Single-cell transcriptomics of peripheral blood mononuclear cells indicates impaired immune and inflammatory responses in alcohol-associated hepatitis	16
Assessing impacts of transfusions on HLA sensitization in pre-hematopoietic stem cell transplant patients	16
Oral abstracts (OR)	15
P608 Recipient allelic imbalance in short tandem repeats chimerism testing indicates disease relapse	15
Nomenclature for factors of the HLA system, update October, November and December 2022	15
O27 A web-based visualization tool for asymmetric linkage disequilibrium (ALD) between amino acid positions of classical HLA loci in US populations	15
Evaluation of the performance of next generation sequencing ABO probes in a solid organ transplant population	14
HLA typing by Next Generation Sequencing (NGS): Validation using MGI DNBSEQ-G99	14
Comparative analysis of serum pretreatment strategies to remove non-specific serum interference in HLA antibody assessment	14
Uncovering the rarity: DR7-DR53-DQ9 haplotype in two Caucasian patients	14
Association of killer cell immunoglobulin-like receptor genes with primary Sjögren’s syndrome among Chinese population	13
Allele and eight-locus haplotype frequencies in population of Belgorod region, Russia	13
Correlation of serum vitamin D levels with serum interleukin-23 levels in patients of ulcerative colitis	13
Epitope mismatch load as potential driver of rejection in xenotransplantation	13
Enhanced prediction of antigen and antibody binding interface using ESM-2 and Bi-LSTM	13
COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort	13
Population study to define HLA in Mohawk First Nation in Quebec	13
Immune-regulatory properties carried by human amnion epithelial cells: Focus on the role of HLA-G and adenosinergic ectoenzymes	13
DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study	13
Oral abstracts (OR)	12
Next-generation sequencing and clinical histocompatibility testing	11
Front Matter	11
Soluble HLA-G is upregulated in serum of patients with severe COVID-19	11
Correlation of serum matrix metalloproteinase 3 with osteoporosis in patients of postmenopausal rheumatoid arthritis	11
O10 Common, intermediate, well-documented and rare HLA eplets in the world population: epCIWDR version 1.0.0	11
A snapshot of human leukocyte antigen (HLA) diversity using data from the Allele Frequency Net Database	11
Different immunoregulatory components at the decidua basalis of oocyte donation pregnancies	11
Guanylate binding protein1 alters expression of the poly I: C induced cytokines/chemokines and MAP kinases in macrophages	11
P527 We have seen it all: Hemi-, homo-, hetero- and now tri-zygous HLA-DR – Unique case described in a healthy donor	10
Single-cell analysis unveils immune dysregulation and EBV-driven lymphoproliferative disorder in pediatric liver transplant recipients	10
HLA study in Mexico Nahua/Aztec Amerindians: Close relatedness to the ancient Central America ethnic groups	10
P209 Adsorption/elution experiments reveal that 166DG and 166ES eplets cross-react	10
Correlation of autoimmune response and immune system components in the progression of IgA nephropathy: A comparative study	10
Concurrent typing of over 4000 samples by long-range PCR amplicon-based NGS and rSSO revealed the need to verify NGS typing for HLA allelic dropouts	10
P517 Assessment of the effect of UNOS new CPRA calculator, implemented in January 2023, on sensitized kidney and pancreas patient population at Cedars Sinai Medical Center	10
Imputing high-resolution genotypes from serological typing in a large clinical cohort	10
HLA-disease association and pleiotropy landscape in over 235,000 Finns	10
P104 Clinical validation of next generation sequencing-based engraftment monitoring for pediatric patients after hematopoietic cell transplantation	10
HLA-DR, -DP, -DQ expression status of parathyroid tissue as a potential parathyroid donor selection criteria and review of literature	9
The impact of PIRCHE-II and ischemia reperfusion injury on dynamics of CD4+ T memory cells in liver transplant recipients	9
Generation of antigen-specific T lymphocytes targeting Wilms tumor 1 using activated B cells	9
Isolating HLA-specific IgM and IgG from serum using different MagSort elution buffers	9
De novo production of granulocyte-macrophage colony-stimulating factor antibodies following hematopoietic stem cell transplantation from HLA-matched unrelated donors is associated with acute graft-ver	9
Reporting HLA antigens for the DRB3/4/5 Locus at the first field in UNet would decrease rates of deceased donor offer refusal	9
Evaluating double-peak melt curves for the LinkSeqTM HLA-B*27 assay	9

Impact of HLA polymorphisms on the susceptibility to SARS-CoV-2 infection and related mortality in patients with renal replacement therapy	9
Identification of highly conserved surface-exposed peptides of spike protein for multiepitope vaccine design against emerging omicron variants: An immunoinformatic approach	8
Class II HLA in Georgia Caucasus Tbilisi Georgians and their Mediterranean ancestry: The Usko Mediterranean languages	8
Combined next generation sequencing for HLA typing and chimerism testing	8
Sex-dependent regulation of interferon-γ receptor expression in pulmonary tuberculosis	8
Intronic region polymorphisms of autophagy gene ATG16L1 predispose individuals to Hepatitis B virus infection	8
Risk HLA alleles in South America and potential new epitopes for SARS-CoV2	8
Point-Counterpoint: Desensitization to improve the likelihood of lung transplantation	8
Intradermal lymphocyte therapy: A promising treatment for recurrent pregnancy loss in patients without anti-TPO antibodies	8
Defining a normal reference range for B cells: A key to diagnosing humoral inborn errors of immunity	8
The role of the HLA allelic repertoire on the clinical severity of COVID-19 in Canadians, living in the Saskatchewan province	8
Expression level of immune checkpoint inhibitory factors in preeclampsia	7
P609 Performance of single antigen plus ExPlex and PRA bead assays in challenging cases of allo-hematopoietic cell transplant patients	7
Mechanism of LMNB1 activating GPR84 through JAK-STAT pathway to mediate M2 macrophage polarization in lung cancer	7
Resolving a relevant DPB1 Exon 3 polymorphism by HLA sequencing	7
Role of T follicular helper cells in autoimmune rheumatic Diseases: A systematic review on immunopathogenesis and response to treatment	7
Exploring bioinformatics tools for graft-versus-host disease risk prediction in hematopoietic cell transplantation: A study conducted at a Mexican center	7
Tools for optimizing risk assessment in hematopoietic cell transplant – What can we get away with?	7
P120 Successful Daratumumab desensitization strategy in a highly sensitized heart transplant patient	7
P623 The A24 mystery – The missing link between solid-phase and cell-based assays	7
Challenges for the standardized reporting of NGS HLA genotyping: Surveying gaps between clinical and research laboratories	7
Establishing the relationship between an adopted recipient and their HLA-matched related donor	7
P709 HLA Class I and II expression on T and B cells from deceased donor peripheral blood, lymph nodes and spleen: Is peripheral blood an equal specimen for physical crossmatch?	7
Nomenclature for factors of the HLA system, update January, February and March 2024	7
Differences in T cell immune-related lncRNA and mRNA expression patterns between right- and left-sided colorectal cancers	7
Evaluation of cfDNA extraction method: for monitoring donor-derived cell-free DNA post-transplantation	7
Sensitive and fast NGS-based chimerism monitoring using ONT sequencing	6
Role of miRNA-155 in macrophage polarisation in stage III/IV periodontitis with type II diabetes mellitus: An analytical case-control study	6
Dr. James M. Mathew appointed Editor-in-Chief of Human Immunology	6
Front Matter	6
Diagnosing coeliac disease: A literature review	6
CTLs, NK cells and NK-derived EVs against breast cancer	6
Reduced levels of liver kinase B1 in small extracellular vesicles as a predictor for chronic lung allograft dysfunction in cystic fibrosis lung transplant recipients	6
Feasibility of long fragment hybrid capture for long-read sequencing of HLA and beyond	6
Cretan HLA genetics supports its early Minoan culture as a link between North Africa and Europe	6
Use of titration for improving quantitative evaluation of Anti-HLA antibodies by SAB	5
P200 Evaluation of PreSorb beads in removing nonspecific reactivities in HLA antibody test by luminex solid phase single antigen beads assay	5
P301 The clinical course of a pre-existing, weak DSA targeting HLA-DR	5
Uncovering new potentials: High resolution deceased donor human leukocyte antigen typing in less than 4 hours	5
Nomenclature for factors of the HLA system, update October, November and December 2024	5
Contribution of survivin to the immune system, allergies and autoimmune diseases	5
Evaluation of serum soluble HLA-G levels post-recovery from COVID-19 and post-vaccination (Sinopharm and Pfizer-BioNTech)	5
P100 HLA-Cw epitope analysis can resolve positive physical flow cytometry crossmatch in absence of donor-specific antibodies and prozone effect – A case study	5
P211 The Mayo Clinic Arizona virtual crossmatch algorithm supporting the largest solid organ transplant program in the United States	5
Altered microRNA expression profile is linked to T-cell exhaustion-related pathways in pediatric patients with acute lymphoblastic leukemia	5
Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphisms	5
Reducing number of laboratories performing complement dependent cytotoxicity crossmatching: Reasons and conclusions	5
New challenges, new opportunities: Next generation sequencing and its place in the advancement of HLA typing	5
Antigen-specific immunotherapy for platelet alloimmune disorders	5
P123 HLA diversity in Brazilian population: Detection of 48 new alleles by next-generation sequencing	5
P219 Kidney transplantation across pre-existing DSA using solely virtual crossmatch results	5
Reconstitution of T cells at three months after stem cell transplant influences the discovery of predictive markers of relapse	5
Association analysis of T and B-cell epitopes with humoral alloimmunisation in kidney transplantation: A Tunisian cohort study	5
Th1 or Th2 cytokines are correlated with Tregs and T cell subsets and pregnancy outcomes in patients with autoimmune thyroid disease during early, middle, late pregnancy, and postpartum period	5
Immune cell infiltration and drug sensitivity in PIK3CA-mutated esophageal squamous cell carcinoma: A TCGA database analysis	5
P522 Characterization of linkage disequilibrium between DRB1*01 and DRB5	4
O39 Characterization of HLA expression on memory-like (ML) NK cells	4
JoGo-LILR caller: Unveiling and navigating the diversity of LILRB3-LILRA6 copy number structures with whole-genome sequencing	4
Serological reactivity of HLA alleles is dependent on race/ethnicity	4
P222 Using epitope analysis to aid in test interpretation and to guide donor matching for a highly sensitized patient	4
P707 Performance and evaluation of a novel NGS assay and software for monitoring dd-cfDNA following kidney transplantation	4
Concurrent use of two independent methods prevents erroneous HLA typing of deceased organ donors – An important strategy for patient safety and accurate virtual crossmatching for broader sharing	4
Chimeric antigen receptor natural killer cell therapy: A systematic review of preclinical studies for hematologic and solid malignancies	4
P514 High background challenges in single antigen bead assay	4
P204 Use of cell-free DNA analysis to determine need for renal transplant biopsy after detection of circulating donor-specific anti-HLA antibodies in renal transplant recipients	4
O12 Identification of DRB1 and DQB1 amino acid variability within serologic antigen groups	4
Effect modification between HLA-F and CD56 markers reveals differences in survival for triple-negative breast cancer patients	4
P212 Investigating HLA-DQ immunogenicity in lung transplantation	4
Comparison of alloimmune risk stratification method for kidney transplants: Correlation with outcomes from a single center pediatric transplant program	4
HLA-B evolutionary divergence is associated with outcomes after SARS-CoV-2 infection	4
Decoding immune tolerance in infertility: Exploring immune pathways and non-coding RNAs as pioneering biomarkers and therapeutic targets	4
P521 Assessment of HLA-associated type 1 diabetes risk in Haiti	4
Not all eplet mismatches are created equal – A cohort study illustrating implications to long-term graft outcomes	4
P115 Assessment of chimerism by next generation sequencing: A comparison to STR/qPCR methods	4
Front Matter	4
Comparison between two commercially available Luminex non-HLA antibody assays	4
lncRNA-mediated immune system dysregulation in RIF; a comprehensive insight into immunological modifications and signaling pathways’ dysregulation	4
P509 Natural knockouts: HLA genotypes with no expressed alleles	4
The number and frequency of mucosal-associated invariant T (MAIT), γδ T, and innate lymphoid cells (ILCs) altered in patients with type I Gaucher disease	4
MiR-155 regulates Th9 differentiation in children with methicillin-resistant Staphylococcus aureus pneumonia by targeting SIRT1	4

Performance assessment of the One Lambda Devyser Accept cfDNA assay in lung transplantation	3
Autobiographical perspectives on HLA epitopes: Past, present and future	3
Dynamics of HLA and angiotensin II type 1 receptor antibodies during pregnancy	3
How natural selection shapes genetic differentiation in the MHC region: A case study with Native Americans	3
Successful third transplant for recurrent leukemia after TLI-ATG conditioning and despite EBV-associated mixed donor chimerism	3
P112 Integrating the Oxford Nanopore MinION bioinformatic pipeline into an HLA laboratory information management system for high-resolution typing workflow	3
O23 NGS HLA typing reveals low-level maternal T cell engraftment through the detection of an unexpected DRB4	3
Coexistence of sickle cell disease and systemic lupus erythematosus is associated with quantitative and qualitative impairments in circulating regulatory B cells	3
Suppressor T helper type 17 cell responses in intestinal transplant recipients with allograft rejection	3
The use of business intelligence software to promote quality and service excellence of laboratory operations	3
Differential adsorption of HLA and non-HLA antibodies following combined liver and kidney transplantation	3
HLA-DRB3/4/5 mismatches were unintentionally avoided in allogenic hematopoietic stem cell transplants	3
miR-150 promotes progressive T cell differentiation via inhibiting FOXP1 and RC3H1	3
Polymorphisms of B-lymphocyte-associated genes CD20 and FCRL5 are associated with susceptibility to autoimmune thyroid diseases	3
Virtual crossmatch (VXM) by the numbers	3
P519 Deciphering the loss of anti-angiotensin type 1 receptor reactivity in enzyme-linked immunosorbent assay post-adsorption	3
Cytokine Dysregulation in pulmonary Tuberculosis: The role of TNF-α/IL-10 and TNF-α/TGF-β ratios as severity indicators	3
Association of serum level of TGF-B1 and its genetic polymorphisms (C509T and T869C) with Ischemic heart disease in Iraqi population	3
Exhausted NK cells and cytokine storms in COVID-19: Whether NK cell therapy could be a therapeutic choice	3
Varying potency of self/cancer peptides in KIR3DL1 recognition of HLA-A*24:02	3
Multi-center evaluation of 19 loci hybrid capture NGS assay on illumina instruments	3
A case-control association study of APOE promoter region variants with glaucoma in North Indian population	3
Increased frequency of CD14+HLA-DR-/low cells in type 2 diabetes patients with poor glycemic control	3
Improvements of Omixon NanoTYPE HLA typing using Oxford Nanopore Technologies: Addressing the DQ3 drop-out issue	3
P207 Virtual crossmatch: Could all HLA-DQB1*03:01P antigens be analyzed in the same way?	3
Astragalus-mediated stimulation on antigen-presenting cells could result in higher IL-21 production from CXCR5+ Tfh-like cells and better IL-21-mediated effector functions	3
The impact of donor-specific antibody and non-HLA antibodies on acute cellular rejection in pediatric liver transplantation	3
O28 Interrogating DSA IgG characteristics and effector functions in lung transplant recipients	3
Undetected mixed chimerism in myeloid subset enrichments by an immunomagnetic bead-based method	3
Allelic Polymorphisms of Killer Immunoglobulin-Like Receptor Genes in Malay and Orang Asli Populations of Peninsular Malaysia	2
P230 Donor-specific HLA antibody characteristics at the time of biopsy with and without antibody-mediated rejection in kidney transplantation	2
Association of IL10 gene SNVs rs1800896 (A>G), rs1800871 (C>T), rs1800872 (C>A) and haplotypes with COVID-19 severity and outcome in the Brazilian population	2
O13 The accuracy of eplet mismatching using imputed intermediate resolution HLA typing	2
A glance at the geographical distribution of histocompatibility laboratories	2
Validating residues determining epitopes and its possible application in clinical histocompatibility testing	2
O26 The performance of a research hybrid-capture NGS assay for high-resolution HLA typing	2
P525 Cracking the code: Exploring the connection between COVID-19 vaccines and HLA antibodies in kidney transplant candidates	2
UCLA International MICA Exchange – An update	2
High-resolution MHC sequencing reveals local genetic architecture of multiple sclerosis in a trans-ethnic cohort	2
O7 Combining allele-specific solvent-accessible surface-protruding amino acid mismatches and predicted indirect T cell epitopes improves HLA matching in predicting kidney graft survival	2
Genome Canada precision medicine strategy for structured national implementation of epitope matching in renal transplantation	2
Applications of next-generation sequencing in hematologic malignancies	2
Association between oral nutrition and inflammation after intestinal transplantation	2
TNFRSF13B in B cell responses to organ transplantation	2
Next generation sequencing for HLA loci in full heritage Pima Indians of Arizona, Part II: HLA-A, -B, and -C with selected non-classical loci at 4-field resolution from whole genome sequences	2
P202 Belimumab causes positive B cell flow cytometric crossmatches with untreated lymphocytes but not with pronase-treated lymphocytes	2
P225 Daratumumab-induced interference with HLA crossmatching in cardiac amyloidosis patients awaiting heart transplantation	2
Author Index	2
Differential gene expression of immune response in COVID-19 and its relationship with progression of COVID-19	2
O11 A computational HLA allele-typing protocol to de-noise and leverage nanopore amplicon data	2
P218 Association of HLA-DRB1*04 with acute severe hepatitis of unknown aetiology in children: Results from an Irish cohort	2
Integrating US census demographic data with HLA frequencies to accelerate targeted cell therapy patient enrollment	2
P109 The DRB4*03:01N allele confounds NGS typing software	2
P224 Reporting a rare KIR genotype lacking framework genes	2
The functional TNFAIP3 rs2230926T/G (Phe127Cys) variant confers risk to systemic lupus erythematosus in a Latin American population	2
Expression of concern: “Humoral immune mechanisms involved in protective and pathological immunity during COVID-19” [Hum. Immunol. 82(10) (2021) 733–745]	2
Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patients	2
Combining nano-curcumin with catechin improves COVID-19-infected patient's inflammatory conditions	2
Vitamin D decreases expression of NLRP1 and NLRP3 inflammasomes in placental explants from women with preeclampsia cultured with hydrogen peroxide	2
Anti-inflammatory action of geopropolis produced by stingless bees on human peripheral blood mononuclear cells	2
O34 HLA-typing using a long-read HLA capture method combined with ONT or PacBio sequencing	2
Nomenclature for factors of the HLA system, update January, February and March 2023	2
HLA homozygosity is associated with Non-Hodgkin lymphoma	2
Nomenclature for factors of the HLA system, update July, August and September 2022	2
P617 Alloimmune endotypes and related outcomes in human liver transplantation	2
HLA-DPB1 and DPA1∼DPB1 linkage mismatch affects the survival of recipients receiving HLA-14/14 matched unrelated donor HSCT	2
High-throughput, high-resolution HLA typing using NGS-Pronto nanopore sequencing – a multicentre performance study	2
P106 DP mischievous: Case reports of isolated de nove DP donor specific antibodies	2
Donor genetic determinant of thymopoiesis, rs2204985, and stem cell transplantation outcome in a multipopulation cohort	2
Is peripheral blood immunophenotyping useful to understand the etiology of Idiopathic Granulomatous?	2
Role of inflammation and immune response in atherosclerosis: Mechanisms, modulations, and therapeutic targets	2
P606 Basecalling accuray of HLA loci using rapid Nanopore sequencing	2