OOIR: Observatory of International Research

Papers

(The H4-Index of European Journal of Medicinal Chemistry is 62. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Contents continued	235
Scaffold hopping-based structural modification of tranilast led to the identification of HNW005 as a promising NLRP3 inflammasome and URAT1 dual inhibitor for the treatment of gouty arthritis	195
Graphical abstract TOC	194
Graphical abstract TOC	172
Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases	169
Nature-inspired new isoindole-based Passerini adducts as efficient tumor-selective apoptotic inducers via caspase-3/7 activation	161
Synthesis and evaluation of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate analogs as competitive partial agonists of butyrophilin 3A1	159
Novel 1,3,4-oxadiazole chalcogen analogues: Synthesis and cytotoxic activity	157
Graphical abstract contents continued	156
Synthesis of tropane-based σ1 receptor antagonists with antiallodynic activity	128
Identification of novel tetrahydroquinoxaline derived phenyl ureas as modulators of the hepatitis B virus nucleocapsid assembly	126
Design and synthesis of forsythin derivatives as anti-inflammatory agents for acute lung injury	117
Editorial Board	116
A pro-death autophagy-based nanoplatform for enhancing antitumour efficacy with improved immune responses	108
Discovery of N-(5-amido-2-methylphenyl)-5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability	106
Synthesis and biological evaluation of novel pyrazole amides as potent mitochondrial complex I inhibitors	102
Rational drug design to explore the structure-activity relationship (SAR) of TRK inhibitors with 2,4-diaminopyrimidine scaffold	101
Corrigendum to “Structure-based development of N-Arylindole derivatives as Pks13 inhibitors against Mycobacterium tuberculosis” [Europ. J. Med. Chem. 283 (2025) 117148]	100
Recent developments in the synthesis of indolizines and their derivatives as compounds of interest in medicinal chemistry: a review	100
Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors	98
Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents	95
Novel nitrogen mustard-artemisinin hybrids with potent anti-leukemia action through DNA damage and activation of GPx	94
Rational design, synthesis and biological evaluation of dual PARP-1/2 and TNKS1/2 inhibitors for cancer therapy	91
A brain-targeting dl-3-n-butylphthalide prodrug to treat ischemic stroke	89
Highly potent dipeptidyl peptidase 8/9 (DPP8/9) inhibitors designed via relative binding free energy calculations	89

Design, synthesis, evaluation and X-ray structural studies of potent HIV-1 protease inhibitors containing substituted oxaspirocyclic carbamates as the P2 ligands	86
Poly(ADP-ribose) polymerase-1 (PARP1)-based dual inhibitors targeting cancer synthetic lethality (2022-present): advances and perspectives	85
Fluorinated sulfonamide-flavonoid derivatives as novel Keap1-Nrf2 inhibitors: Potent induction of cytoprotective gene HO-1 in vivo	85
Corrigendum to “Design, synthesis and evaluation of carbamate-bridged amino acid prodrugs of cycloicaritin with improved antitumor activity, aqueous solubility and phase II metabolic stability” [Eur.	84
Peptide inhibitors targeting Ras and Ras-associated protein–protein interactions	83
Structure-based approaches for the design of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d][1,2,3]triazoles as tubulin polymerization inhibitors	83
Antitumor activity and transcriptome sequencing (RNA-seq) analyses of hepatocellular carcinoma cells in response to exposure triterpene-nucleoside conjugates	82
Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors	81
Synthesis and evaluation of a new class of MIF-inhibitors in activated macrophage cells and in experimental septic shock in mice	81
Non-nucleoside structured compounds with antiviral activity—past 10 years (2010–2020)	81
Water molecules in the cannabinoid receptor 2 binding site crucially impact the discovery of novel ligands	80
Platinum(IV) complexes as inhibitors of CD47-SIRPα axis for chemoimmunotherapy of cancer	78
Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration	77
Engineering a biomimicking strategy for discovering nonivamide-based quorum-sensing inhibitors for controlling bacterial infection	76
Novel β-carboline derivatives show promise as dual-target inhibitors of DNA and TOP2A for the treatment of triple negative breast cancer	76
Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs	75
Design, synthesis and in vitro evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors	73
Synthesis and antibacterial medicinal evaluation of carbothioamido hydrazonyl thiazolylquinolone with multitargeting antimicrobial potential to combat increasingly global resistance	73
Vitamin K-Trolox synergism realized in hybrid neuroprotectant with potent anti-ferroptosi/oxytosis activity, reduced toxicity, and in vivo efficacy in Alzheimer's disease mouse model	72
Discovery of a potent, selective and cell active inhibitor of m6A demethylase ALKBH5	72
Discovery of small molecules for autophagy-lysosome degradation of immune checkpoint proteins	70
Synthesis and biological evaluation of α-D-tocopherol derivatives as anticancer agents targeting mitochondrial metabolism	70
Novel pterostilbene derivatives ameliorate heart failure by reducing oxidative stress and inflammation through regulating Nrf2/NF-κB signaling pathway	70
Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase	70
Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist	70
Synthesis of diarylpentane derivatives as novel α-glucosidase inhibitors: Their inhibitory mechanism and hypoglycemic effects	69
Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities	67
Discovery of novel fluorine-containing parthenolide analogues as potential antitumor agents	66
6-Regioisomeric 5,8-quinolinediones as potent CDC25 inhibitors against colorectal cancers	66
Design, synthesis, and biological evaluation of piperazine derivatives as pan-PPARs agonists for the treatment of liver fibrosis	65
Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration	65
Estrogen receptor β-targeted hypoxia-responsive near-infrared fluorescence probes for prostate cancer study	64
Exploring Si-phthalocyanines with different valency for PSMA-targeted photodynamic therapy: Synthesis and preclinical validation	63
Synthesis of 8-aminomorphans with high KOR affinity	63
Synthesis and evaluation of 3,4,5-trisubstituted triazoles as G protein-biased kappa opioid receptor agonists	63
[18F]R91150: Improved radiosynthesis and in vivo evaluation as imaging probe for 5-HT2A receptors	62
Coumarin–benzimidazole hybrids: A review of developments in medicinal chemistry	62