European Journal of Medicinal Chemistry

Article	Citations
Editorial Board	441
Graphical abstract contents continued	198
Discovery of novel dual tubulin and MMPs inhibitors for the treatment of lung cancer and overcoming drug resistance	179
Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy	164
[18F]R91150: Improved radiosynthesis and in vivo evaluation as imaging probe for 5-HT2A receptors	151
Corrigendum to “Structure-based development of N-Arylindole derivatives as Pks13 inhibitors against Mycobacterium tuberculosis” [Europ. J. Med. Chem. 283 (2025) 117148]	144
Contents continued	143
Identification of novel tetrahydroquinoxaline derived phenyl ureas as modulators of the hepatitis B virus nucleocapsid assembly	142
Graphical abstract TOC	142
Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors	138
Non-nucleoside structured compounds with antiviral activity—past 10 years (2010–2020)	137
Design, synthesis, and biological evaluation of piperazine derivatives as pan-PPARs agonists for the treatment of liver fibrosis	131
Discovery of N-(5-amido-2-methylphenyl)-5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability	117
Structure-based discovery of a 4,5-Dihydropyrazole-cored PET ligand for imaging of receptor-interacting serine/threonine-protein kinase 1 (RIPK1) in the brain	115
Synthesis of 8-aminomorphans with high KOR affinity	110
Graphical abstract TOC	107
Estrogen receptor β-targeted hypoxia-responsive near-infrared fluorescence probes for prostate cancer study	103
1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors	102
Synthesis, anti-allergic rhinitis evaluation and mechanism investigation of novel 1,2,4-triazole-enamides as CB1 R antagonist	98
Synthesis and evaluation of 3,4,5-trisubstituted triazoles as G protein-biased kappa opioid receptor agonists	94
Rational molecular design converting fascaplysin derivatives to potent broad-spectrum inhibitors against bacterial pathogens via targeting FtsZ	94
H2dpa derivatives containing pentadentate ligands: An acyclic adjuvant potentiates meropenem activity in vitro and in vivo against metallo-β-lactamase-producing Enterobacterales	94
From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series	93
Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration	91
Antitumor activity and transcriptome sequencing (RNA-seq) analyses of hepatocellular carcinoma cells in response to exposure triterpene-nucleoside conjugates	90

Discovery of ML210-Based glutathione peroxidase 4 (GPX4) degrader inducing ferroptosis of human cancer cells	90
Identification of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase	88
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity	87
6-Regioisomeric 5,8-quinolinediones as potent CDC25 inhibitors against colorectal cancers	86
Structure-based approaches for the design of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d][1,2,3]triazoles as tubulin polymerization inhibitors	86
An update on small molecule compounds targeting synthetic lethality for cancer therapy	84
Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases	82
Palladium-mediated synthesis and biological evaluation of C-10b substituted Dihydropyrrolo[1,2-b]isoquinolines as antileishmanial agents	81
Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies	80
Small-molecule MDM2 inhibitors in clinical trials for cancer therapy	80
Rational drug design to explore the structure-activity relationship (SAR) of TRK inhibitors with 2,4-diaminopyrimidine scaffold	78
Oleanolic acid derivatives against drug-resistant bacteria and fungi by multi-targets to avoid drug resistance	76
Novel 1,3,4-oxadiazole chalcogen analogues: Synthesis and cytotoxic activity	76
Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation	76
Probing benzenesulfonamide–thiazolidinone hybrids as multitarget directed ligands for efficient control of type 2 diabetes mellitus through targeting the enzymes: α-glucosidase and carbonic anhydrase	75
Novel bifluorescent Zn(II)–cryptolepine–cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells	75
Nature-inspired new isoindole-based Passerini adducts as efficient tumor-selective apoptotic inducers via caspase-3/7 activation	74
The mechanism of UNC-51-like kinase 1 and the applications of small molecule modulators in cancer treatment	73
Rational design, synthesis and biological evaluation of dual PARP-1/2 and TNKS1/2 inhibitors for cancer therapy	73
Design, synthesis and in vitro evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors	73
Coumarin–benzimidazole hybrids: A review of developments in medicinal chemistry	72
Design and synthesis of forsythin derivatives as anti-inflammatory agents for acute lung injury	72
Application of deuterium in research and development of drugs	71
Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors	70
Synthesis of cinnamoyl tethered indoline derivatives with anti-inflammatory and antioxidant activities	70
Discovery of the novel Benzo[b]thiophene 1,1-dioxide derivatives as a potent STAT3 inhibitor against idiopathic pulmonary fibrosis	70
Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs	69
A glycyrrhetinic acid-iridium(III) conjugate as a theranostic NIR probe for hepatocellular carcinoma with mitochondrial-targeting ability	68
Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents	68
Exploring Si-phthalocyanines with different valency for PSMA-targeted photodynamic therapy: Synthesis and preclinical validation	68
A brain-targeting dl-3-n-butylphthalide prodrug to treat ischemic stroke	68
Novel nitrogen mustard-artemisinin hybrids with potent anti-leukemia action through DNA damage and activation of GPx	67
Synthesis and evaluation of a new class of MIF-inhibitors in activated macrophage cells and in experimental septic shock in mice	67
Discovery of 3H-pyrrolo[2,3-c]quinolines with activity against Mycobacterium tuberculosis by allosteric inhibition of the glutamate-5-kinase enzyme	66
Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses	65
Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration	65
Corrigendum to “Design, synthesis and evaluation of carbamate-bridged amino acid prodrugs of cycloicaritin with improved antitumor activity, aqueous solubility and phase II metabolic stability” [Eur.	64
Fluorinated sulfonamide-flavonoid derivatives as novel Keap1-Nrf2 inhibitors: Potent induction of cytoprotective gene HO-1 in vivo	64
Novel 3-hydroxypyridin-4(1H)-One derivatives as ferroptosis inhibitors with iron-chelating and reactive oxygen species scavenging activities and therapeutic effect in cisplatin-induced cytotoxicity	64
Discovery of small molecules for autophagy-lysosome degradation of immune checkpoint proteins	61
Discovery of novel fused-heterocycle-bearing diarypyrimidine derivatives as HIV-1 potent NNRTIs targeting tolerant region I for enhanced antiviral activity and resistance profile	61
Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells	60
Synthesis of tropane-based σ1 receptor antagonists with antiallodynic activity	60
New β-arylchalcogeno amines with procognitive properties targeting Carbonic Anhydrases and Monoamine Oxidases	59
Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors	58
Novel pterostilbene derivatives ameliorate heart failure by reducing oxidative stress and inflammation through regulating Nrf2/NF-κB signaling pathway	57
A pro-death autophagy-based nanoplatform for enhancing antitumour efficacy with improved immune responses	57
A decade of USFDA-approved small molecules as anti-inflammatory agents: Recent trends and Commentaries on the “industrial” perspective	56
Applications of oxetanes in drug discovery and medicinal chemistry	56
Discovery of novel fluorine-containing parthenolide analogues as potential antitumor agents	56

Discovery and biological evaluation of 6-aryl-4-(3,4,5-trimethoxyphenyl)quinoline derivatives with promising antitumor activities as novel colchicine-binding site inhibitors	56
Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities	55
Synthesis and antibacterial medicinal evaluation of carbothioamido hydrazonyl thiazolylquinolone with multitargeting antimicrobial potential to combat increasingly global resistance	55
Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase	54
Pyrazolopyrimidines as anticancer agents: A review on structural and target-based approaches	54
Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy	54
Cinnamic acid derivatives linked to arylpiperazines as novel potent inhibitors of tyrosinase activity and melanin synthesis	54
Design, synthesis and biological evaluation of 1H-indazole derivatives as novel ASK1 inhibitors	54
Discovery of a potent, selective and cell active inhibitor of m6A demethylase ALKBH5	54
Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis	53
Synthesis and evaluation of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate analogs as competitive partial agonists of butyrophilin 3A1	52
Peptide inhibitors targeting Ras and Ras-associated protein–protein interactions	52
EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model	52
Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of RORγ antagonists	52
Engineering a biomimicking strategy for discovering nonivamide-based quorum-sensing inhibitors for controlling bacterial infection	51
Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies	51
Platinum(IV) complexes as inhibitors of CD47-SIRPα axis for chemoimmunotherapy of cancer	51
Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist	51
Synthesis and biological evaluation of novel pyrazole amides as potent mitochondrial complex I inhibitors	51
Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010–2020)	51
Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy	51
Histone deacetylases (HDACs) as the promising immunotherapeutic targets for hematologic cancer treatment	51
The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead	51
Scaffold hopping-based structural modification of tranilast led to the identification of HNW005 as a promising NLRP3 inflammasome and URAT1 dual inhibitor for the treatment of gouty arthritis	50
Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors	50
Graphical abstract TOC	50
Design and synthesis of benzothiazole aryl urea derivatives as potent anti-staphylococcal agents targeting autolysin-mediated peptidoglycan hydrolases	50
Graphical abstract TOC	50
Arginine and tryptophan-rich dendritic antimicrobial peptides that disrupt membranes for bacterial infection in vivo	50
Current trends in computer aided drug design and a highlight of drugs discovered via computational techniques: A review	50
Synthesis and application of small molecules approved for the treatment of lymphoma	50
Design, synthesis, and biological activity evaluation of novel HDAC3 selective inhibitors for combination with Venetoclax against acute myeloid leukemia	49
Contents continued	49
Design, synthesis, and antitumor evaluation of triazolopyridine derivatives as novel inhibitors for BRD4	49
Graphical abstract TOC	49
Innovative C-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4	49
Contents continued	49
Monofunctional dimetallic Ru(η6-arene) complexes inhibit NOTCH1 signaling pathway and synergistically enhance anticancer effect in combination with cisplatin or vitamin C	48
Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses	48
Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma	48
Design, synthesis and bioactivity evaluation of novel evodiamine derivatives with excellent potency against gastric cancer	48
Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1′-region optimisation	48
Bioisosteric replacement of 1H-1,2,3-triazole with 1H-tetrazole ring enhances anti-leukemic activity of (5-benzylthiazol-2-yl)benzamides	47
Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models	47
Targeted vancomycin delivery via in situ albumin conjugation and acid-triggered drug release for reduced nephrotoxicity	46
Development of a next-generation endogenous OCT4 inducer and its anti-aging effect in vivo	46
A deep learning model for structure-based bioactivity optimization and its application in the bioactivity optimization of a SARS-CoV-2 main protease inhibitor	46
Tandem construction of biological relevant aliphatic 5-membered N-heterocycles	46
O-derivatization of natural tropolone and β-thujaplicin leading to effective inhibitors of human carbonic anhydrases IX and XII	46
Exploring the potential of histone demethylase inhibition in multi-therapeutic approaches for cancer treatment	45
Synthesis, design, and optimization of a potent and selective series of pyridylpiperazines as promising antimalarial agents	45
Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency	45
Rational design and appraisal of selective Cdc2-Like kinase 1 (Clk1) inhibitors as novel autophagy inducers for the treatment of acute liver injury (ALI)	45
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for n	45
Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting	44
Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease	44
Immunosuppressive effects of new thiophene-based KV1.3 inhibitors	44
Design, synthesis, in vitro – In vivo biological evaluation of novel thiazolopyrimidine compounds as antileishmanial agent with PTR1 inhibition	44
Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of	44
Briarane-type diterpenoids, the inhibitors of osteoclast formation by interrupting Keap1-Nrf2 interaction and activating Nrf2 pathway	44
Multicomponent syntheses enable the discovery of novel quisinostat-derived chemotypes as histone deacetylase inhibitors	44
Antimicrobial activity of natural and semi-synthetic carbazole alkaloids	43
Design and synthesis of novel derivatives of bisepoxylignans as potent anti-inflammatory agents involves the modulation of the M1/M2 microglia phenotype via TLR4/NF-κB signaling pathway	43
An overview on Estrogen receptors signaling and its ligands in breast cancer	43
Advancing Src kinase inhibition: From structural design to therapeutic innovation - A comprehensive review	42
Graphical abstract TOC	42
Benzimidazole analogues active against adult Schistosoma mansoni: SAR analyses, In vivo efficacy in mice, and preliminary mechanistic studies as potential inhibitors of hemozoin formation	42
Graphical abstract TOC	42
Development of novel S-N3-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity	42
Synthesis and evaluation of novel ebselen derivatives as urease inhibitors for combating Helicobacter pylori infections	42
Novel antimalarial 3-substituted quinolones isosteres with improved pharmacokinetic properties	42
Inhibitors of ABCG2-mediated multidrug resistance: Lead generation through computer-aided drug design	41
Synthesis of 10,10′-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro	41
Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists	41
Editorial Board	41
Aurora kinase inhibitors as potential anticancer agents: Recent advances	41
Structure-activity relationship studies and design of a PTPN22 inhibitor with enhanced isozyme selectivity and cellular efficacy	41
Recent developments in antimalarial activities of 4-aminoquinoline derivatives	40
3-Hydroxy-pyridin-4(1H)-ones as siderophores mediated delivery of isobavachalcone enhances antibacterial activity against pathogenic Pseudomonas aeruginosa	40
Novel angiogenesis inhibitors with superoxide anion radical amplification effect: Surmounting the Achilles’ heels of angiogenesis inhibitors and photosensitizers	40

Structure-directed identification of pyridine-2-methylamine derivatives as MmpL3 inhibitors for use as antitubercular agents	40
Mitochondrial targeted hierarchical drug delivery system based on HA-modified liposomes for cancer therapy	40
Novel neuroprotective 5,6-dihydropyrido[2′,1':2,3]imidazo[4,5-c]quinoline derivatives acting through cholinesterase inhibition and CB2 signaling modulation	40
The journey of p38 MAP kinase inhibitors: From bench to bedside in treating inflammatory diseases	40
Progress of NIR-II fluorescence imaging technology applied to disease diagnosis and treatment	40
Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo	40
Design, synthesis and biological evaluation of pleuromutilin-Schiff base hybrids as potent anti-MRSA agents in vitro and in vivo	39
Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease	39
Structure-based discovery of potent USP28 inhibitors derived from Vismodegib	39
Design, development and evaluation of a prodrug-type TrkA-selective inhibitor with antinociceptive effects in vivo	39
Design, synthesis and biological evaluation of new parbendazole derivatives for the treatment of HNSCC	38
Recent progress toward developing axial chirality bioactive compounds	38
Development of fibroblast activation protein-α radiopharmaceuticals: Recent advances and perspectives	38
SAR and lead optimization of (Z)-5-(4-hydroxy-3-methoxybenzylidene)-3-(2-morpholinoacetyl)thiazolidine-2,4-dione as a potential multi-target antidiabetic agent	38
Design, synthesis and anticancer evaluation of novel Se-NSAID hybrid molecules: Identification of a Se-indomethacin analog as a potential therapeutic for breast cancer	38
Mucormycosis: A hidden mystery of fungal infection, possible diagnosis, treatment and development of new therapeutic agents	37
Microbial-derived peptides with anti-mycobacterial potential	37
Design and synthesis of new 1,2,3-triazoles derived from eugenol and analogues with in vitro and in vivo activity against Trypanosoma cruzi	37
Discovery of novel diaryl substituted isoquinolin-1(2H)-one derivatives as hypoxia-inducible factor-1 signaling inhibitors for the treatment of rheumatoid arthritis	37
2-Phenoxy-3, 4′-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization	37
Water-soluble derivatives of evodiamine: Discovery of evodiamine-10-phosphate as an orally active antitumor lead compound	37
Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents	37
Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor	37
Discovery, enantioselective synthesis of myrtucommulone E analogues as tyrosyl-DNA phosphodiesterase 2 inhibitors and their biological activities	36
Discovery of 4-(N-dithiobenzyl piperazine)-1,8-naphthalimide as a potent multi-target antitumor agent with good efficacy, limited toxicity, and low resistance	36
Amphiphilic small molecule antimicrobials: From cationic antimicrobial peptides (CAMPs) to mechanism-related, structurally-diverse antimicrobials	36
Hydrazinecarboxamides: Comprehensive review of their anticancer, anticonvulsive, anti-inflammatory, enzyme inhibition, antioxidant and other activities	36
Promises of anionic calix[n]arenes in life science: State of the art in 2023	36
Design, synthesis, and biological evaluation of diphenyl ether substituted quinazolin-4-amine derivatives as potent EGFRL858R/T790M/C797S inhibitors	36
From garden to lab: C-3 chemical modifications of tomatidine unveil broad-spectrum ATP synthase inhibitors to combat bacterial resistance	36
Recent advances in triazoles as tyrosinase inhibitors	36
Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT2A receptor antagonists for nonalcoholic fatty liver disease	36
Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease	36
Macrocyclic-based strategy in drug design: From lab to the clinic	36
Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease	36
New broad-spectrum and potent antibacterial agents with dual-targeting mechanism: Promoting FtsZ polymerization and disrupting bacterial membranes	36
Discovery of a novel dual-target inhibitor of CDK12 and PARP1 that induces synthetic lethality for treatment of triple-negative breast cancer	36
Novel dual-target FAAH and TRPV1 ligands as potential pharmacotherapeutics for pain management	35
Antibody-drug conjugates for targeted cancer therapy: Recent advances in potential payloads	35
Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone	35
Recent advances on the development of NO-releasing molecules (NORMs) for biomedical applications	35
Aporphines: A privileged scaffold in CNS drug discovery	35
Graphical abstract TOC	35
Contents continued	34
Graphical abstract TOC	34
Expanding the utilization of binding pockets proves to be effective for noncovalent small molecule inhibitors against SARS-CoV-2 Mpro	34
Identification of thiophene-benzenesulfonamide derivatives for the treatment of multidrug-resistant tuberculosis	34
How many organic small molecules might be used to treat COVID-19? From natural products to synthetic agents	34
Editorial Board	34
A pH-Dependent rhodamine fluorophore with antiproliferative activity of bladder cancer in Vitro/Vivo and apoptosis mechanism	34
Graphical abstract TOC	34
Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and i	34
New N-aryl-N′-aryl-/(thio)ureido-/sulfamoylamino-derivatives of alkyl/alkylcarbamoyl piperazines: Effect of structural modifications on selectivity over 5-HT1A receptor	34
Graphical abstract TOC	34
Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment	34
Graphical abstract TOC	34
Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization	34
An oleanic acid decorated gold nanorod for highly efficient inhibition of hemagglutinin and visible rapid detection of the influenza virus	34
Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds	34
Discovery of novel polyheterocyclic neuraminidase inhibitors with 1,3,4-oxadiazole thioetheramide as core backbone	33
Data-oriented protein kinase drug discovery	33
PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties	33
An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer	33
Synthesis and evaluation of N-sulfonylpiperidine-3-carboxamide derivatives as capsid assembly modulators inhibiting HBV in vitro and in HBV-transgenic mice	33
Editorial Board	33
Corrigendum to “Design, synthesis, and biological evaluation of 1,6-naphthyridine-2-one derivatives as novel FGFR4 inhibitors for the treatment of colorectal cancer” [Eur. J. Med. Chem. 259 (2023) 115	33
Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthi	33
Editorial Board	33
A novel viscosity sensitive hemicyanine fluorescent dye for real-time imaging of amyloid-β aggregation	32
Carbamoylation at C-8 position of natural 3-arylcoumarin scaffold for the discovery of novel PARP-1 inhibitors with potent anticancer activity	32
Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors	32
Novel substituted 4-(Arylethynyl)-Pyrrolo[2,3-d]pyrimidines negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu5) Treat depressive disorder in mice	32
Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia	32
Structure-activity relationship study of new carbazole sulfonamide derivatives as anticancer agents with dual-target mechanism	32
Structure-based discovery of potent myosin inhibitors to guide antiparasite drug development	32
Design, synthesis and biological evaluation of biaryl amide derivatives against SARS-CoV-2 with dual-target mechanism	32
Hit-to-lead optimization of 4,5-dihydrofuran-3-sulfonyl scaffold against Leishmania amazonensis. Effect of an aliphatic moiety	32
Quaternary ammonium cations conjugated 5,15-diaryltetranaphtho[2,3]porphyrins as photosensitizers for photodynamic therapy	32
Application of carbohydrates in approved small molecule drugs: A review	32
Synthesis and structure-activity relationships of novel 14-membered 2-fluoro ketolides with structural modification at the C11 position	32
Identification and immunological evaluation of novel TLR2 agonists through structural optimization of Diprovocim	32
Discovery of 4-amino-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one derivatives as potential receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors	32
SILAC-based chemoproteomics reveals a neoligan analogue as an anti-inflammatory agent targeting IRGM to ameliorate cytokine storm	32
Graphical abstract TOC	32
A novel antimicrobial peptide with broad-spectrum and exceptional stability derived from the natural peptide Brevicidine	32
Emerging roles of fatty acid metabolism in cancer and their targeted drug development	31
2-(Phenylamino)-7,8-dihydroquinazolin-5(6H)-one, a promising scaffold for MAO-B inhibitors with potential GSK3β targeting	31
Peptidylarginine deiminases 4 as a promising target in drug discovery	31
Discovery of potent and selective c-Met inhibitors for MET-amplified hepatocellular carcinoma treatment	31
Recent advances in the development of inhibitors targeting KRAS-G12C and its related pathways	31
Designed and synthesized novel tripeptides targeting diabetes and its related pathologies	31
Design, synthesis and anti-ovarian cancer activities of thieno[2,3-d]pyrimidine based chimeric BRD4 inhibitor/nitric oxide-donator	31
Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo	31
Insight into small-molecule inhibitors targeting extracellular nucleotide pyrophosphatase/phosphodiesterase1 for potential multiple human diseases	31
Comprehensive coverage on anti-mycobacterial endeavour reported during 2022	31