European Journal of Medicinal Chemistry

Article	Citations
Editorial Board	414
Graphical abstract contents continued	178
Discovery of novel dual tubulin and MMPs inhibitors for the treatment of lung cancer and overcoming drug resistance	169
Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy	145
A decade of USFDA-approved small molecules as anti-inflammatory agents: Recent trends and Commentaries on the “industrial” perspective	141
[18F]R91150: Improved radiosynthesis and in vivo evaluation as imaging probe for 5-HT2A receptors	138
Corrigendum to “Structure-based development of N-Arylindole derivatives as Pks13 inhibitors against Mycobacterium tuberculosis” [Europ. J. Med. Chem. 283 (2025) 117148]	135
Contents continued	131
Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors	128
Graphical abstract TOC	124
Identification of novel tetrahydroquinoxaline derived phenyl ureas as modulators of the hepatitis B virus nucleocapsid assembly	121
H2dpa derivatives containing pentadentate ligands: An acyclic adjuvant potentiates meropenem activity in vitro and in vivo against metallo-β-lactamase-producing Enterobacterales	121
Synthesis and biological evaluation of novel pyrazole amides as potent mitochondrial complex I inhibitors	110
Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors	109
Non-nucleoside structured compounds with antiviral activity—past 10 years (2010–2020)	106
Design, synthesis, and biological evaluation of piperazine derivatives as pan-PPARs agonists for the treatment of liver fibrosis	98
Design and synthesis of forsythin derivatives as anti-inflammatory agents for acute lung injury	97
Structure-based approaches for the design of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d][1,2,3]triazoles as tubulin polymerization inhibitors	94
Discovery of N-(5-amido-2-methylphenyl)-5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability	92
Structure-based discovery of a 4,5-Dihydropyrazole-cored PET ligand for imaging of receptor-interacting serine/threonine-protein kinase 1 (RIPK1) in the brain	90
6-Regioisomeric 5,8-quinolinediones as potent CDC25 inhibitors against colorectal cancers	88
Synthesis of 8-aminomorphans with high KOR affinity	87
Graphical abstract TOC	87
Oleanolic acid derivatives against drug-resistant bacteria and fungi by multi-targets to avoid drug resistance	87
Estrogen receptor β-targeted hypoxia-responsive near-infrared fluorescence probes for prostate cancer study	86

Identification of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase	84
Synthesis of cinnamoyl tethered indoline derivatives with anti-inflammatory and antioxidant activities	82
Synthesis, anti-allergic rhinitis evaluation and mechanism investigation of novel 1,2,4-triazole-enamides as CB1 R antagonist	81
Discovery of N-substituted sulfamoylbenzamide derivatives as novel inhibitors of STAT3 signaling pathway based on Niclosamide	80
Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs	80
Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist	78
Peptide inhibitors targeting Ras and Ras-associated protein–protein interactions	77
Exploring Si-phthalocyanines with different valency for PSMA-targeted photodynamic therapy: Synthesis and preclinical validation	76
Palladium-mediated synthesis and biological evaluation of C-10b substituted Dihydropyrrolo[1,2-b]isoquinolines as antileishmanial agents	76
A brain-targeting dl-3-n-butylphthalide prodrug to treat ischemic stroke	76
Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents	76
Discovery of a potent, selective and cell active inhibitor of m6A demethylase ALKBH5	76
A glycyrrhetinic acid-iridium(III) conjugate as a theranostic NIR probe for hepatocellular carcinoma with mitochondrial-targeting ability	75
Cinnamic acid derivatives linked to arylpiperazines as novel potent inhibitors of tyrosinase activity and melanin synthesis	74
Histone deacetylases (HDACs) as the promising immunotherapeutic targets for hematologic cancer treatment	72
Novel nitrogen mustard-artemisinin hybrids with potent anti-leukemia action through DNA damage and activation of GPx	71
Small-molecule MDM2 inhibitors in clinical trials for cancer therapy	71
New β-arylchalcogeno amines with procognitive properties targeting Carbonic Anhydrases and Monoamine Oxidases	71
Discovery of the novel Benzo[b]thiophene 1,1-dioxide derivatives as a potent STAT3 inhibitor against idiopathic pulmonary fibrosis	69
Synthesis and evaluation of a new class of MIF-inhibitors in activated macrophage cells and in experimental septic shock in mice	68
Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies	68
Rational drug design to explore the structure-activity relationship (SAR) of TRK inhibitors with 2,4-diaminopyrimidine scaffold	67
Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases	67
Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of RORγ antagonists	67
Discovery of 3H-pyrrolo[2,3-c]quinolines with activity against Mycobacterium tuberculosis by allosteric inhibition of the glutamate-5-kinase enzyme	67
Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors	65
Rational design, synthesis and biological evaluation of dual PARP-1/2 and TNKS1/2 inhibitors for cancer therapy	65
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity	64
Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration	64
A pro-death autophagy-based nanoplatform for enhancing antitumour efficacy with improved immune responses	63
Probing benzenesulfonamide–thiazolidinone hybrids as multitarget directed ligands for efficient control of type 2 diabetes mellitus through targeting the enzymes: α-glucosidase and carbonic anhydrase	63
Synthesis and evaluation of 3,4,5-trisubstituted triazoles as G protein-biased kappa opioid receptor agonists	63
Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration	63
Discovery of novel fused-heterocycle-bearing diarypyrimidine derivatives as HIV-1 potent NNRTIs targeting tolerant region I for enhanced antiviral activity and resistance profile	62
EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model	62
Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation	61
Engineering a biomimicking strategy for discovering nonivamide-based quorum-sensing inhibitors for controlling bacterial infection	61
Synthesis of tropane-based σ1 receptor antagonists with antiallodynic activity	60
From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series	60
Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase	60
Discovery and biological evaluation of 6-aryl-4-(3,4,5-trimethoxyphenyl)quinoline derivatives with promising antitumor activities as novel colchicine-binding site inhibitors	60
Design, synthesis, and biological evaluation of some 2-(3-oxo-5,6-diphenyl-1,2,4-triazin-2(3H)-yl)-N-phenylacetamide hybrids as MTDLs for Alzheimer's disease therapy	57
Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis	57
Novel 1,3,4-oxadiazole chalcogen analogues: Synthesis and cytotoxic activity	56
Design, synthesis and biological evaluation of 1H-indazole derivatives as novel ASK1 inhibitors	56
Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies	56
Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities	56
1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors	55
Antitumor activity and transcriptome sequencing (RNA-seq) analyses of hepatocellular carcinoma cells in response to exposure triterpene-nucleoside conjugates	54
Application of deuterium in research and development of drugs	54

Platinum(IV) complexes as inhibitors of CD47-SIRPα axis for chemoimmunotherapy of cancer	54
Discovery of ML210-Based glutathione peroxidase 4 (GPX4) degrader inducing ferroptosis of human cancer cells	53
Pyrazolopyrimidines as anticancer agents: A review on structural and target-based approaches	53
Novel bifluorescent Zn(II)–cryptolepine–cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells	53
Arginine and tryptophan-rich dendritic antimicrobial peptides that disrupt membranes for bacterial infection in vivo	53
Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells	52
Discovery of novel fluorine-containing parthenolide analogues as potential antitumor agents	52
Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010–2020)	52
The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead	52
Coumarin–benzimidazole hybrids: A review of developments in medicinal chemistry	51
Novel pterostilbene derivatives ameliorate heart failure by reducing oxidative stress and inflammation through regulating Nrf2/NF-κB signaling pathway	51
Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy	50
Design, synthesis and in vitro evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors	50
Synthesis and evaluation of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate analogs as competitive partial agonists of butyrophilin 3A1	50
Current trends in computer aided drug design and a highlight of drugs discovered via computational techniques: A review	49
Nature-inspired new isoindole-based Passerini adducts as efficient tumor-selective apoptotic inducers via caspase-3/7 activation	49
Synthesis and antibacterial medicinal evaluation of carbothioamido hydrazonyl thiazolylquinolone with multitargeting antimicrobial potential to combat increasingly global resistance	49
An update on small molecule compounds targeting synthetic lethality for cancer therapy	49
The mechanism of UNC-51-like kinase 1 and the applications of small molecule modulators in cancer treatment	49
Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors	49
Rational molecular design converting fascaplysin derivatives to potent broad-spectrum inhibitors against bacterial pathogens via targeting FtsZ	49
Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses	49
Discovery of small molecules for autophagy-lysosome degradation of immune checkpoint proteins	49
Applications of oxetanes in drug discovery and medicinal chemistry	49
Synthesis and application of small molecules approved for the treatment of lymphoma	48
Novel 3-hydroxypyridin-4(1H)-One derivatives as ferroptosis inhibitors with iron-chelating and reactive oxygen species scavenging activities and therapeutic effect in cisplatin-induced cytotoxicity	48
Graphical abstract TOC	48
Graphical abstract TOC	48
Graphical abstract TOC	48
Contents continued	47
Design, synthesis and biological evaluation of new parbendazole derivatives for the treatment of HNSCC	47
Design, synthesis, and antitumor evaluation of triazolopyridine derivatives as novel inhibitors for BRD4	47
Exploring the potential of histone demethylase inhibition in multi-therapeutic approaches for cancer treatment	47
Contents continued	47
Inhibitors of ABCG2-mediated multidrug resistance: Lead generation through computer-aided drug design	47
Design, synthesis, and biological activity evaluation of novel HDAC3 selective inhibitors for combination with Venetoclax against acute myeloid leukemia	47
Design, synthesis and bioactivity evaluation of novel evodiamine derivatives with excellent potency against gastric cancer	46
Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor	46
Innovative C-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4	46
Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses	46
Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1′-region optimisation	46
Water-soluble derivatives of evodiamine: Discovery of evodiamine-10-phosphate as an orally active antitumor lead compound	46
Multicomponent syntheses enable the discovery of novel quisinostat-derived chemotypes as histone deacetylase inhibitors	46
Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma	45
Benzimidazole analogues active against adult Schistosoma mansoni: SAR analyses, In vivo efficacy in mice, and preliminary mechanistic studies as potential inhibitors of hemozoin formation	45
Monofunctional dimetallic Ru(η6-arene) complexes inhibit NOTCH1 signaling pathway and synergistically enhance anticancer effect in combination with cisplatin or vitamin C	45
Development of fibroblast activation protein-α radiopharmaceuticals: Recent advances and perspectives	44
Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of	44
Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models	44
Macrocyclic-based strategy in drug design: From lab to the clinic	43
Bioisosteric replacement of 1H-1,2,3-triazole with 1H-tetrazole ring enhances anti-leukemic activity of (5-benzylthiazol-2-yl)benzamides	43
O-derivatization of natural tropolone and β-thujaplicin leading to effective inhibitors of human carbonic anhydrases IX and XII	43
Structure-directed identification of pyridine-2-methylamine derivatives as MmpL3 inhibitors for use as antitubercular agents	43
Recent progress toward developing axial chirality bioactive compounds	42
An overview on Estrogen receptors signaling and its ligands in breast cancer	42
Mucormycosis: A hidden mystery of fungal infection, possible diagnosis, treatment and development of new therapeutic agents	42
Novel dual-target FAAH and TRPV1 ligands as potential pharmacotherapeutics for pain management	42
A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders	42
Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease	42
Design, synthesis, in vitro – In vivo biological evaluation of novel thiazolopyrimidine compounds as antileishmanial agent with PTR1 inhibition	42
Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease	42
Recent advances on the development of NO-releasing molecules (NORMs) for biomedical applications	42
2-Phenoxy-3, 4′-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization	42
Discovery of 4-(N-dithiobenzyl piperazine)-1,8-naphthalimide as a potent multi-target antitumor agent with good efficacy, limited toxicity, and low resistance	42
Tandem construction of biological relevant aliphatic 5-membered N-heterocycles	41
Development of a next-generation endogenous OCT4 inducer and its anti-aging effect in vivo	41
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for n	41
Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists	41
Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone	41
Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency	41
Immunosuppressive effects of new thiophene-based KV1.3 inhibitors	41
From garden to lab: C-3 chemical modifications of tomatidine unveil broad-spectrum ATP synthase inhibitors to combat bacterial resistance	41
Synthesis, design, and optimization of a potent and selective series of pyridylpiperazines as promising antimalarial agents	41
Development of novel S-N3-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity	40
Aporphines: A privileged scaffold in CNS drug discovery	40
Graphical abstract TOC	40
Structure-based discovery of potent USP28 inhibitors derived from Vismodegib	40
Graphical abstract TOC	39
Design and synthesis of novel derivatives of bisepoxylignans as potent anti-inflammatory agents involves the modulation of the M1/M2 microglia phenotype via TLR4/NF-κB signaling pathway	39
Synthesis and evaluation of novel ebselen derivatives as urease inhibitors for combating Helicobacter pylori infections	39

Advancing Src kinase inhibition: From structural design to therapeutic innovation - A comprehensive review	39
Design and synthesis of new 1,2,3-triazoles derived from eugenol and analogues with in vitro and in vivo activity against Trypanosoma cruzi	38
Rational design and appraisal of selective Cdc2-Like kinase 1 (Clk1) inhibitors as novel autophagy inducers for the treatment of acute liver injury (ALI)	38
Novel neuroprotective 5,6-dihydropyrido[2′,1':2,3]imidazo[4,5-c]quinoline derivatives acting through cholinesterase inhibition and CB2 signaling modulation	38
The journey of p38 MAP kinase inhibitors: From bench to bedside in treating inflammatory diseases	38
Structure-activity relationship studies and design of a PTPN22 inhibitor with enhanced isozyme selectivity and cellular efficacy	38
Recent developments in antimalarial activities of 4-aminoquinoline derivatives	38
Editorial Board	38
Discovery, enantioselective synthesis of myrtucommulone E analogues as tyrosyl-DNA phosphodiesterase 2 inhibitors and their biological activities	38
Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease	38
Design, synthesis and biological evaluation of pleuromutilin-Schiff base hybrids as potent anti-MRSA agents in vitro and in vivo	37
Design, synthesis and anticancer evaluation of novel Se-NSAID hybrid molecules: Identification of a Se-indomethacin analog as a potential therapeutic for breast cancer	37
Promises of anionic calix[n]arenes in life science: State of the art in 2023	37
New broad-spectrum and potent antibacterial agents with dual-targeting mechanism: Promoting FtsZ polymerization and disrupting bacterial membranes	37
Antibody-drug conjugates for targeted cancer therapy: Recent advances in potential payloads	37
Synthesis of 10,10′-bis(trifluoromethyl) marinopyrrole A derivatives and evaluation of their antiviral activities in vitro	37
Novel angiogenesis inhibitors with superoxide anion radical amplification effect: Surmounting the Achilles’ heels of angiogenesis inhibitors and photosensitizers	37
Progress of NIR-II fluorescence imaging technology applied to disease diagnosis and treatment	37
Amphiphilic small molecule antimicrobials: From cationic antimicrobial peptides (CAMPs) to mechanism-related, structurally-diverse antimicrobials	37
Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents	37
Briarane-type diterpenoids, the inhibitors of osteoclast formation by interrupting Keap1-Nrf2 interaction and activating Nrf2 pathway	37
Recent advances in triazoles as tyrosinase inhibitors	36
Aurora kinase inhibitors as potential anticancer agents: Recent advances	36
Hydrazinecarboxamides: Comprehensive review of their anticancer, anticonvulsive, anti-inflammatory, enzyme inhibition, antioxidant and other activities	36
SAR and lead optimization of (Z)-5-(4-hydroxy-3-methoxybenzylidene)-3-(2-morpholinoacetyl)thiazolidine-2,4-dione as a potential multi-target antidiabetic agent	36
Design, development and evaluation of a prodrug-type TrkA-selective inhibitor with antinociceptive effects in vivo	36
Novel antimalarial 3-substituted quinolones isosteres with improved pharmacokinetic properties	36
Discovery of a novel dual-target inhibitor of CDK12 and PARP1 that induces synthetic lethality for treatment of triple-negative breast cancer	36
Microbial-derived peptides with anti-mycobacterial potential	36
Advancement of chimeric hybrid drugs to cure malaria infection: An overview with special emphasis on endoperoxide pharmacophores	36
Discovery of novel diaryl substituted isoquinolin-1(2H)-one derivatives as hypoxia-inducible factor-1 signaling inhibitors for the treatment of rheumatoid arthritis	36
Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT2A receptor antagonists for nonalcoholic fatty liver disease	35
3-Hydroxy-pyridin-4(1H)-ones as siderophores mediated delivery of isobavachalcone enhances antibacterial activity against pathogenic Pseudomonas aeruginosa	35
Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo	35
Mitochondrial targeted hierarchical drug delivery system based on HA-modified liposomes for cancer therapy	35
Antimicrobial activity of natural and semi-synthetic carbazole alkaloids	35
Design, synthesis, and biological evaluation of diphenyl ether substituted quinazolin-4-amine derivatives as potent EGFRL858R/T790M/C797S inhibitors	35
Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease	34
Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment	34
Graphical abstract TOC	34
Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting	34
Editorial Board	34
Graphical abstract TOC	34
Graphical abstract TOC	34
Contents continued	34
A pH-Dependent rhodamine fluorophore with antiproliferative activity of bladder cancer in Vitro/Vivo and apoptosis mechanism	33
Structure-based drug design of an inhibitor of the SARS-CoV-2 (COVID-19) main protease using free software: A tutorial for students and scientists	33
Plant-derived strategies to fight against severe acute respiratory syndrome coronavirus 2	33
Design, synthesis and biological evaluation of conformationnally-restricted analogues of E7010 as inhibitors of tubulin assembly (ITA) and vascular disrupting agents (VDA)	33
Graphical abstract TOC	33
Lanosterol 14α-demethylase (CYP51)/histone deacetylase (HDAC) dual inhibitors for treatment of Candida tropicalis and Cryptococcus neoformans infections	33
A novel Al18F-labelled NOTA-modified ubiquicidin 29-41 derivative as a bacterial infection PET imaging agent	33
Recent advances in the development of inhibitors targeting KRAS-G12C and its related pathways	33
Graphical abstract TOC	33
An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer	33
Expanding the utilization of binding pockets proves to be effective for noncovalent small molecule inhibitors against SARS-CoV-2 Mpro	33
A novel antimicrobial peptide with broad-spectrum and exceptional stability derived from the natural peptide Brevicidine	32
Synthesis and evaluation of N-sulfonylpiperidine-3-carboxamide derivatives as capsid assembly modulators inhibiting HBV in vitro and in HBV-transgenic mice	32
Design, synthesis and anti-ovarian cancer activities of thieno[2,3-d]pyrimidine based chimeric BRD4 inhibitor/nitric oxide-donator	32
Isoalantolactone/hydroxamic acid hybrids as potent dual STAT3/HDAC inhibitors and self-assembled nanoparticles for cancer therapy	32
Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization	32
Corrigendum to “Design, synthesis, and biological evaluation of 1,6-naphthyridine-2-one derivatives as novel FGFR4 inhibitors for the treatment of colorectal cancer” [Eur. J. Med. Chem. 259 (2023) 115	32
Structural basis for specific inhibition of salicylate synthase from Mycobacterium abscessus	32
Simultaneous inhibition of FLT3 and HDAC by novel 6-ethylpyrazine-2-Carboxamide derivatives provides therapeutic advantages in acute myelocytic leukemia	32
Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthi	32
Discovery of novel polyheterocyclic neuraminidase inhibitors with 1,3,4-oxadiazole thioetheramide as core backbone	32
Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and i	31
Comprehensive coverage on anti-mycobacterial endeavour reported during 2022	31
PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties	31
Data-oriented protein kinase drug discovery	31
Diversity-oriented synthesis and bioactivity evaluation of N-substituted ferrocifen compounds as novel antiproliferative agents against TNBC cancer cells	31
Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors	31
Synthesis and biological evaluation of fluoroquinolones containing a pyridoxine derivatives moiety	31
Discovery of 6-aryl-2-(3,4,5-trimethoxyphenyl)thiazole[3,2-b][1,2,4]triazoles as potent tubulin polymerization inhibitors	31
Development of high-affinity fluorinated ligands for cannabinoid subtype 2 receptor, and in vitro evaluation of a radioactive tracer for imaging	31
The antibacterial properties of branched peptides based on poly(l-arginine): In vitro antibacterial evaluation and molecular dynamic simulations	31
Synthesis and preliminary anticancer evaluation of photo-responsive prodrugs of hydroxymethylene bisphosphonate alendronate	31
Design, synthesis and biological characterization of novel activators of the TrkB neurotrophin receptor	30
Editorial Board	30
Carbamoylation at C-8 position of natural 3-arylcoumarin scaffold for the discovery of novel PARP-1 inhibitors with potent anticancer activity	30
Synthesis and structure-activity relationships of novel 14-membered 2-fluoro ketolides with structural modification at the C11 position	30
Hit-to-lead optimization of 4,5-dihydrofuran-3-sulfonyl scaffold against Leishmania amazonensis. Effect of an aliphatic moiety	30
Novel substituted 4-(Arylethynyl)-Pyrrolo[2,3-d]pyrimidines negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu5) Treat depressive disorder in mice	30
New N-aryl-N′-aryl-/(thio)ureido-/sulfamoylamino-derivatives of alkyl/alkylcarbamoyl piperazines: Effect of structural modifications on selectivity over 5-HT1A receptor	30
A novel viscosity sensitive hemicyanine fluorescent dye for real-time imaging of amyloid-β aggregation	30
Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors	30
Synthesis and in vivo screening of isosteviol derivatives as new cardioprotective agents	30
Structure-activity relationship study of new carbazole sulfonamide derivatives as anticancer agents with dual-target mechanism	30
Design, synthesis and biological evaluation of biaryl amide derivatives against SARS-CoV-2 with dual-target mechanism	30
Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo	30
Editorial Board	30
Structure-based discovery of potent myosin inhibitors to guide antiparasite drug development	30
Discovery of 4-amino-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one derivatives as potential receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors	30
Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds	30
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design	30