European Journal of Medicinal Chemistry

Papers
(The TQCC of European Journal of Medicinal Chemistry is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
ArticleCitations
Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status332
Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview276
Current trends in computer aided drug design and a highlight of drugs discovered via computational techniques: A review251
β-lactam antibiotics: An overview from a medicinal chemistry perspective239
Alzheimer’s disease and its treatment by different approaches: A review209
An insight on medicinal attributes of 1,2,4-triazoles166
Recent developments of gallic acid derivatives and their hybrids in medicinal chemistry: A review163
RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic138
Application of sulfoximines in medicinal chemistry from 2013 to 2020133
A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer’s disease agents: A review131
Bioactive pyrrole-based compounds with target selectivity130
hERG toxicity assessment: Useful guidelines for drug design126
Antibacterial activities with the structure-activity relationship of coumarin derivatives119
The development of Coronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020118
Research progress of mTOR inhibitors117
Design and discovery of boronic acid drugs116
Small molecule selenium-containing compounds: Recent development and therapeutic applications114
Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges112
Anticancer property of ginsenoside Rh2 from ginseng106
Chalcone hybrids as privileged scaffolds in antimalarial drug discovery: A key review100
The importance of indole and azaindole scaffold in the development of antitumor agents97
Indole-based derivatives as potential antibacterial activity against methicillin-resistance Staphylococcus aureus (MRSA)96
Pyrazole-based analogs as potential antibacterial agents against methicillin-resistance staphylococcus aureus (MRSA) and its SAR elucidation95
Synthetic and medicinal perspective of quinolines as antiviral agents86
In vitro and in vivo anticancer activity of tridentate thiosemicarbazone copper complexes: Unravelling an unexplored pharmacological target86
Treatment for liver cancer: From sorafenib to natural products82
Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation82
Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine82
Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective82
A promising antiviral candidate drug for the COVID-19 pandemic: A mini-review of remdesivir78
Recent advance on PTP1B inhibitors and their biomedical applications77
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors77
A review: Pharmacological aspects of metal based 1,2,4-triazole derived Schiff bases77
Current development of CBP/p300 inhibitors in the last decade76
Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation73
1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)73
Recent advancements in the development of bioactive pyrazoline derivatives73
Therapeutic strategies to overcome cisplatin resistance in ovarian cancer72
The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules72
Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes72
A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery72
PROTACs to address the challenges facing small molecule inhibitors70
A review: Biologically active 3,4-heterocycle-fused coumarins69
Current scenario of indole derivatives with potential anti-drug-resistant cancer activity69
FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application68
Recent accomplishments on the synthetic/biological facets of pharmacologically active 1H-1,2,3-triazoles68
Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update67
Quercetin derivatives: Drug design, development, and biological activities, a review67
Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L166
Camptothecin's journey from discovery to WHO Essential Medicine: Fifty years of promise66
Chemotherapy and chemo-resistance in nasopharyngeal carcinoma66
Developments of CRBN-based PROTACs as potential therapeutic agents66
Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment66
Azithromycin: The First Broad-spectrum Therapeutic65
Novel quinazoline-based EGFR kinase inhibitors: A review focussing on SAR and molecular docking studies (2015-2019)65
A review on the structure and pharmacological activity of phenylethanoid glycosides65
Recent advancements in the development of heterocyclic anti-inflammatory agents64
Antimicrobial drugs bearing guanidine moieties: A review64
Recent advances in DNA gyrase-targeted antimicrobial agents63
Contemporary approaches and future perspectives of antibacterial photodynamic therapy (aPDT) against methicillin-resistant Staphylococcus aureus (MRSA): A systematic review63
Penicillin binding protein 2a: An overview and a medicinal chemistry perspective63
Exploration of carbamide derived pyrimidine-thioindole conjugates as potential VEGFR-2 inhibitors with anti-angiogenesis effect62
Resveratrol – A comprehensive review of recent advances in anticancer drug design and development62
Pt(II) and Au(III) complexes containing Schiff-base ligands: A promising source for antitumor treatment62
Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors61
Potentials of nanotechnology in treatment of methicillin-resistant Staphylococcus aureus61
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies60
Research progress of indole compounds with potential antidiabetic activity60
Discovery of potent small molecule PROTACs targeting mutant EGFR60
Recent advances in the design and discovery of synthetic tyrosinase inhibitors60
A key review on oxadiazole analogs as potential methicillin-resistant Staphylococcus aureus (MRSA) activity: Structure-activity relationship studies60
Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats59
Exosomes from different cells: Characteristics, modifications, and therapeutic applications59
First orally bioavailable prodrug of proteolysis targeting chimera (PROTAC) degrades cyclin-dependent kinases 2/4/6 in vivo59
Structural insights of oxindole based kinase inhibitors as anticancer agents: Recent advances59
A review on ferulic acid and analogs based scaffolds for the management of Alzheimer’s disease59
Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity58
Recent research progress on natural small molecule bibenzyls and its derivatives in Dendrobium species58
Effective degradation of EGFRL858R+T790M mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems58
Fight against novel coronavirus: A perspective of medicinal chemists57
Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies57
DYRK1A inhibitors for disease therapy: Current status and perspectives55
Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study55
Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents55
Synthesis and biological evaluation of organoselenium (NSAIDs-SeCN and SeCF3) derivatives as potential anticancer agents55
Therapeutic progression of quinazolines as targeted chemotherapeutic agents55
Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights55
Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy55
β-Carbolines as potential anticancer agents55
PROTAC: A promising technology for cancer treatment54
Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase54
Pyrimidine-based EGFR TK inhibitors in targeted cancer therapy54
The role of imidazole and benzimidazole heterocycles in Chagas disease: A review53
Natural and synthetic coumarins as antileishmanial agents: A review53
The nano delivery systems and applications of mRNA52
Xanthenes in Medicinal Chemistry – Synthetic strategies and biological activities52
Targeting estrogen receptor α for degradation with PROTACs: A promising approach to overcome endocrine resistance52
Development of Mcl-1 inhibitors for cancer therapy51
Novel 2-indolinone thiazole hybrids as sunitinib analogues: Design, synthesis, and potent VEGFR-2 inhibition with potential anti-renal cancer activity51
Anticancer potential of spirocompounds in medicinal chemistry: A pentennial expedition51
Development of a Brigatinib degrader (SIAIS117) as a potential treatment for ALK positive cancer resistance51
Hydroxamate siderophores: Natural occurrence, chemical synthesis, iron binding affinity and use as Trojan horses against pathogens51
Antimalarial application of quinones: A recent update50
Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules50
Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges50
A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials50
Small molecule therapeutics for tauopathy in Alzheimer’s disease: Walking on the path of most resistance50
Recent advances of quinones as a privileged structure in drug discovery50
Drug repositioning: Progress and challenges in drug discovery for various diseases49
Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC)49
Kojic acid–natural product conjugates as mushroom tyrosinase inhibitors49
Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors49
Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion48
New manganese(II), iron(II), cobalt(II), nickel(II) and copper(II) saccharinate complexes of 2,6-bis(2-benzimidazolyl)pyridine as potential anticancer agents48
Current status and future prospects of p38α/MAPK14 kinase and its inhibitors48
Indole chalcones: Design, synthesis, in vitro and in silico evaluation against Mycobacterium tuberculosis48
Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors48
Recent advances in DDR (DNA damage response) inhibitors for cancer therapy48
Free radical scavengers: An overview on heterocyclic advances and medicinal prospects48
The state of the art of PROTAC technologies for drug discovery48
Coumarin–benzimidazole hybrids: A review of developments in medicinal chemistry48
Inhibitors of gelatinases (MMP-2 and MMP-9) for the management of hematological malignancies48
Design, synthesis and in vivo evaluation of 3-arylcoumarin derivatives of rhenium(I) tricarbonyl complexes as potent antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)47
Targeting mTOR for fighting diseases: A revisited review of mTOR inhibitors47
Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease46
Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds46
Indomethacin-based PROTACs as pan-coronavirus antiviral agents46
Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry46
Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress45
Anticancer boron-containing prodrugs responsive to oxidative stress from the tumor microenvironment45
Anti-tuberculosis activity and its structure-activity relationship (SAR) studies of oxadiazole derivatives: A key review45
Vitamin D and its analogs as anticancer and anti-inflammatory agents45
Novel coumarin aminophosphonates as potential multitargeting antibacterial agents against Staphylococcus aureus45
Synergistic effects of curcumin and its analogs with other bioactive compounds: A comprehensive review45
An insight in anti-malarial potential of indole scaffold: A review45
Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities45
Pluronic-based nanovehicles: Recent advances in anticancer therapeutic applications45
3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies45
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders44
Quinoline anticancer agents active on DNA and DNA-interacting proteins: From classical to emerging therapeutic targets44
The heat shock response and small molecule regulators44
Epoxide containing molecules: A good or a bad drug design approach44
1,2,4-Oxadiazole topsentin analogs as staphylococcal biofilm inhibitors targeting the bacterial transpeptidase sortase A43
Andrographolide and its derivatives: Current achievements and future perspectives43
Targeting drug delivery system for platinum(Ⅳ)-Based antitumor complexes43
A comprehensive description of GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists43
Design and characterization of cereblon-mediated androgen receptor proteolysis-targeting chimeras43
Meroterpenoids produced by fungi: Occurrence, structural diversity, biological activities, and their molecular targets43
Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy43
The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy–Current progress and future direction43
Identification of novel potent and non-toxic anticancer, anti-angiogenic and antimetastatic rhenium complexes against colorectal carcinoma43
Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation43
Dihydrofolate reductase inhibitors for use as antimicrobial agents43
Small-molecule inhibitors of breast cancer-related targets: Potential therapeutic agents for breast cancer42
Efficient targeted oncogenic KRASG12C degradation via first reversible-covalent PROTAC42
Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway42
Design, synthesis, and in vitro and in vivo anti-angiogenesis study of a novel vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor based on 1,2,3-triazole scaffold42
The new opportunities in medicinal chemistry of fourth-generation EGFR inhibitors to overcome C797S mutation41
Novel strategies targeting bromodomain-containing protein 4 (BRD4) for cancer drug discovery41
Adamantane derivatives as potential inhibitors of p37 major envelope protein and poxvirus reproduction. Design, synthesis and antiviral activity41
Design, synthesis and in vitro evaluation of novel SARS-CoV-2 3CLpro covalent inhibitors41
Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China41
Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms40
The antibacterial activity of fluoroquinolone derivatives: An update (2018–2021)40
Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents40
Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases40
2-Aminothiazole: A privileged scaffold for the discovery of anti-cancer agents40
Modulators of CFTR. Updates on clinical development and future directions40
Discovery of highly potent tubulin polymerization inhibitors: Design, synthesis, and structure-activity relationships of novel 2,7-diaryl-[1,2,4]triazolo[1,5-a]pyrimidines40
Design and synthesis of 3-(4-pyridyl)-5-(4-sulfamido-phenyl)-1,2,4-oxadiazole derivatives as novel GSK-3β inhibitors and evaluation of their potential as multifunctional anti-Alzheimer agents40
Medicinal chemistry updates of novel HDACs inhibitors (2020 to present)40
Discovery of metal-based complexes as promising antimicrobial agents40
Elephantopinolide A-P, germacrane-type sesquiterpene lactones from Elephantopus scaber induce apoptosis, autophagy and G2/M phase arrest in hepatocellular carcinoma cells40
Cyclic tailor-made amino acids in the design of modern pharmaceuticals40
Novel NHC-coordinated ruthenium(II) arene complexes achieve synergistic efficacy as safe and effective anticancer therapeutics39
Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines39
Design, preparation and evaluation of different branched biotin modified liposomes for targeting breast cancer39
Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis39
Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer’s disease38
New drug approvals for 2019: Synthesis and clinical applications38
Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors38
Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010–2020)38
Recent applications of vinyl sulfone motif in drug design and discovery38
Development of MDM2 degraders based on ligands derived from Ugi reactions: Lessons and discoveries38
Natural and nature-inspired stilbenoids as antiviral agents38
Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity38
Emerging small-molecule inhibitors of the Bruton’s tyrosine kinase (BTK): Current development38
Synthesis and biological activities of drugs for the treatment of osteoporosis37
p62 as a therapeutic target for tumor37
Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR)37
Discovery of novel cell-penetrating and tumor-targeting peptide-drug conjugate (PDC) for programmable delivery of paclitaxel and cancer treatment37
Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR37
Synthesis and biological evaluation of gold(III) Schiff base complexes for the treatment of hepatocellular carcinoma through attenuating TrxR activity37
2-substituted benzothiazoles as antiproliferative agents: Novel insights on structure-activity relationships37
Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus37
Discovery of new phenyl sulfonyl-pyrimidine carboxylate derivatives as the potential multi-target drugs with effective anti-Alzheimer’s action: Design, synthesis, crystal structure and in-vitro biolog37
STING, a promising target for small molecular immune modulator: A review37
Antioxidant activity of novel quinazolinones bearing sulfonamide: Potential radiomodulatory effects on liver tissues via NF-κB/ PON1 pathway36
Synthesis, and biological evaluation of 3,6-diaryl-[1,2,4]triazolo[4,3-a]pyridine analogues as new potent tubulin polymerization inhibitors36
Review of the development of BTK inhibitors in overcoming the clinical limitations of ibrutinib36
Design, synthesis, and bioevaluation of pyrazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site with potent anticancer activities36
Design, synthesis, and biological evaluation of nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit br36
Non-invasive intranasal administration route directly to the brain using dendrimer nanoplatforms: An opportunity to develop new CNS drugs36
Breaking down the cell wall: Strategies for antibiotic discovery targeting bacterial transpeptidases36
Recent advance of peptide-based molecules and nonpeptidic small-molecules modulating PD-1/PD-L1 protein-protein interaction or targeting PD-L1 protein degradation36
Targeting EZH2 for cancer therapy: From current progress to novel strategies36
Specific stabilization of promoter G-Quadruplex DNA by 2,6-disubstituted amidoanthracene-9,10-dione based dimeric distamycin analogues and their selective cancer cell cytotoxicity36
Advance of structural modification of nucleosides scaffold35
Combining histone deacetylase inhibitors (HDACis) with other therapies for cancer therapy35
Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential35
An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a35
Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease35
Polypharmacological drug actions of recently FDA approved antibiotics35
A comprehensive overview of β-carbolines and its derivatives as anticancer agents35
Synthesis of some new benzoxazole derivatives and investigation of their anticancer activities35
Recent research and development of NDM-1 inhibitors35
Aurora kinase inhibitors as potential anticancer agents: Recent advances35
Small-molecule MDM2 inhibitors in clinical trials for cancer therapy35
New insight into 20(S)-ginsenoside Rh2 against T-cell acute lymphoblastic leukemia associated with the gut microbiota and the immune system35
Design, synthesis and evaluation of novel bis-substituted aromatic amide dithiocarbamate derivatives as colchicine site tubulin polymerization inhibitors with potent anticancer activities35
Poly ethylene glycol (PEG)-Related controllable and sustainable antidiabetic drug delivery systems35
Tryptophan derived natural marine alkaloids and synthetic derivatives as promising antimicrobial agents35
Hypoxia-activated nanomedicines for effective cancer therapy35
Development of triazolothiadiazine derivatives as highly potent tubulin polymerization inhibitors: Structure-activity relationship, in vitro and in vivo study34
Therapeutic potential of uracil and its derivatives in countering pathogenic and physiological disorders34
Antitubercular properties of thiazolidin-4-ones – A review34
New deferiprone derivatives as multi-functional cholinesterase inhibitors: design, synthesis and in vitro evaluation34
Factor XII/XIIa inhibitors: Their discovery, development, and potential indications34
N-alkylpiperidine carbamates as potential anti-Alzheimer’s agents34
Hydrogen sulfide donors: Therapeutic potential in anti-atherosclerosis34
5-Fluorouracil nano-delivery systems as a cutting-edge for cancer therapy34
Roles and drug development of METTL3 (methyltransferase-like 3) in anti-tumor therapy34
Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model34
Recent achievements of bioluminescence imaging based on firefly luciferin-luciferase system34
Investigating the antibacterial activity of salen/salophene metal complexes: Induction of ferroptosis as part of the mode of action34
Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens34
Medicinal chemistry strategies for the development of protein tyrosine phosphatase SHP2 inhibitors and PROTAC degraders34
Pyrimidine: A promising scaffold for optimization to develop the inhibitors of ABC transporters34
Design, synthesis and evaluation of novel thienopyrimidine-based agents bearing diaryl urea functionality as potential inhibitors of angiogenesis34
Discovery of a PROTAC targeting ALK with in vivo activity33
Adenosine receptor antagonists: Recent advances and therapeutic perspective33
An update into the medicinal chemistry of translocator protein (TSPO) ligands33
Annual review of lysine-specific demethylase 1 (LSD1/KDM1A) inhibitors in 202133
Synthesis, DNA binding, antibacterial and anticancer properties of two novel water-soluble copper(II) complexes containing gluconate33
Novel curcumin derivatives as P-glycoprotein inhibitors: Molecular modeling, synthesis and sensitization of multidrug resistant cells to doxorubicin33
PROTACs: New method to degrade transcription regulating proteins33
Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety33
Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors33
Discovery of coumarin derivatives as potent and selective cyclin-dependent kinase 9 (CDK9) inhibitors with high antitumour activity33
Recent contributions of quinolines to antimalarial and anticancer drug discovery research33
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