OOIR: Observatory of International Research

Papers

(The median citation count of Archives of Pharmacal Research is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Mouse models of nonalcoholic steatohepatitis and their application to new drug development	178
Evaluation of bone health and fracture risk in type 2 diabetes: a network meta-analysis of anti-diabetic treatments versus placebo	138
CD48-expressing non-small-cell lung cancer cells are susceptible to natural killer cell–mediated cytotoxicity	68
Renal tubular PAR2 promotes interstitial fibrosis by increasing inflammatory responses and EMT process	67
Correction to: Recent advances in CRISPR technologies for genome editing	67
Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation	55
Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities	51
Osteogenic effect of an adiponectin-derived short peptide that rebalances bone remodeling: a potential disease-modifying approach for postmenopausal osteoporosis therapy	49
Correction to: The multifaceted role of STAT3 pathway and its implication as a potential therapeutic target in oral cancer	48
Anti-fibrotic effect of aurocyanide, the active metabolite of auranofin	46
Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease mouse model: novel mechanistic insight	44
Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration	43
Impact of binge drinking on alcoholic liver disease	39
Retraction Note: Anti-inflammatory effect of atorvastatin on vascular reactivity and insulin resistance in fructose fed rats	39
Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway	38
Donepezil improves skeletal muscle insulin resistance in obese mice via the AMPK/FGF21-mediated suppression of inflammation and ferroptosis	34
Advances in plant-derived natural products for antitumor immunotherapy	34
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways	33
Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions	33
Minor structural changes, major functional impacts: posttranslational modifications and drug targets	31
The role and application of transcriptional repressors in cancer treatment	31
Non-alcoholic fatty liver disease and liver secretome	30
A review on bacteria-derived antioxidant metabolites: their production, purification, characterization, potential applications, and limitations	30
Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes	28
Isolation, structure elucidation, total synthesis, and biosynthesis of dermazolium A, an antibacterial imidazolium metabolite of a vaginal bacterium Dermabacter vaginalis	28

Effects of fluconazole on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes	27
Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis	27
Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation	26
Molecular epigenetic dynamics in breast carcinogenesis	25
Triterpenoids from Dysoxylum genus and their biological activities	24
Ginsenoside Rh1 inhibits tumor growth in MDA-MB-231 breast cancer cells via mitochondrial ROS and ER stress-mediated signaling pathway	24
Phytochemistry and pharmacology of plants in the genus Chaenomeles	21
Anti-angiogenesis revisited: reshaping the treatment landscape of advanced non-small cell lung cancer	21
The inhibition of endothelial DLL4-NOTCH1 signaling by 2'-hydroxyflavanone enhances anti-PD-1 therapy in melanoma	21
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2	21
Predictive biomarkers for molecularly targeted therapies and immunotherapies in breast cancer	21
Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions	21
Immunosenescence and age-related immune cells: causes of age-related diseases	20
Dapagliflozin attenuates myocardial remodeling in hypertension by activating the circadian rhythm signaling pathway	20
The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model	20
Discovery and synthesis of 1,2,4-oxadiazole derivatives as novel inhibitors of Zika, dengue, Japanese encephalitis, and classical swine fever virus infections	19
Pralsetinib: chemical and therapeutic development with FDA authorization for the management of RET fusion-positive non-small-cell lung cancers	18
Correction to: Site-selective and metal-free C–H nitration of biologically relevant N-heterocycles	18
Potential effects of a human milk oligosaccharide 6′-sialyllactose on angiotensin II-induced aortic aneurysm via p90RSK/TGF-β/SMAD2 signaling pathway	18
Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects	18
Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes	18
New tricyclic systems as photosensitizers towards triple negative breast cancer cells	17
Biomedical features and therapeutic potential of rosmarinic acid	17
Paeonia genus: a systematic review of active ingredients, pharmacological effects and mechanisms, and clinical applications for the treatment of cancer	17
Effects of CYP2C93 and 13 alleles on the pharmacokinetics and pharmacodynamics of glipizide in healthy Korean subjects	17
Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review	17
Potential of natural products in inflammation: biological activities, structure–activity relationships, and mechanistic targets	17
Akt-activated GSK3β inhibitory peptide effectively blocks tau hyperphosphorylation	16
Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone	16
Cardiotoxicity linked to anticancer agents and cardioprotective strategy	16
Immune-related pathogenesis and therapeutic strategies of nonalcoholic steatohepatitis	16
Inhibition of autophagy with chloroquine dysregulates mitochondrial quality control and energetics in adipocytes	16
Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC	16
Mechanistic insights and emerging therapeutic strategies targeting endothelial dysfunction in cardiovascular diseases	16
Biodegradable gelatin methacryloyl microneedles: a new paradigm in transdermal drug delivery	16
New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1)	15
Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism	15
Advanced therapeutic strategies targeting microglia: beyond neuroinflammation	15
Physiologically based pharmacokinetic (PBPK) modeling of pitavastatin in relation to SLCO1B1 genetic polymorphism	15
Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment	14
Activation of cryptic biosynthetic pathways in Saccharopolyspora spinosa through deletion of the spinosyn gene cluster: induction of cryptic and bioactive natural products	14
Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies	14
Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose attenuate LPS-induced lung injury by inhibiting STAT1 and NF-κB signaling pathways	14
Curcumin targets CXCL16-mediated podocyte injury and lipid accumulation in diabetic kidney disease treatment	14
PET tracer development for imaging α-synucleinopathies	13
Physiologically based pharmacokinetic modelling to predict the pharmacokinetics of metoprolol in different CYP2D6 genotypes	13
Dual roles of myeloid-derived suppressor cells in various diseases: a review	13
Effects of CYP2D6*10 allele on the pharmacokinetics of tolperisone	13
Biological insights and therapeutic potential of Glycyrrhiza uralensis and its bioactive compounds: an updated review	12
Physiologically based pharmacokinetic modeling of candesartan related to CYP2C9 genetic polymorphism in adult and pediatric patients	11

Curcumin monoglucuronide protects cartilage from progressive degeneration by blocking MMP-13	11
Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals	11
Effects of CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy subjects	11
E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice	11
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells	11
Physiologically based pharmacokinetic (PBPK) modeling of gliclazide for different genotypes of CYP2C9 and CYP2C19	11
Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides	11
Protection of the hematopoietic system against radiation-induced damage: drugs, mechanisms, and developments	10
Role of mitochondrial dynamics and mitophagy of vascular smooth muscle cell proliferation and migration in progression of atherosclerosis	10
Indole-3-acetic acid ameliorates dextran sulfate sodium-induced colitis via the ERK signaling pathway	10
Ionically bridged dexamethasone sodium phosphate–zinc–PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis	10
Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1β and IL-4/MCP-1 signaling pathways	10
Latest research progress on anticancer effect of baicalin and its aglycone baicalein	10
Exploring NNMT: from metabolic pathways to therapeutic targets	10
Role of monocarboxylate transporter I/lactate dehydrogenase B-mediated lactate recycling in tamoxifen-resistant breast cancer cells	10
Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function	10
Comparative evaluation of bioactive phytochemicals in Spinacia oleracea cultivated under greenhouse and open field conditions	9
mRNA vaccines: the most recent clinical applications of synthetic mRNA	9
Modulating versatile pathways using a cleavable PEG shell and EGFR-targeted nanoparticles to deliver CRISPR-Cas9 and docetaxel for triple-negative breast cancer inhibition	9
Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins	9
Low-dose curcumin enhances hippocampal neurogenesis and memory retention in young mice	8
Apocynin abrogates methotrexate-induced nephrotoxicity: role of TLR4/NF-κB-p65/p38-MAPK, IL-6/STAT-3, PPAR-γ, and SIRT1/FOXO3 signaling pathways	8
Retraction Note: MiR-338-5p ameliorates pathological cardiac hypertrophy by targeting CAMKIIδ	8
Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management	8
Antitumor activity of Polygonatum sibiricum polysaccharides	8
Oleanolic acid activates the JNK-Sp1-DJ-1 axis to promote mitophagy-mediated neuroprotection in dopaminergic neurons for Parkinson’s disease treatment	8
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis	8
Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs	8
Targeting dysregulated lipid metabolism in the tumor microenvironment	7
Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine	7
Silybin inhibits succinate production and secretion in hepatocytes to reverse liver fibrosis	7
Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells	7
Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway	7
Prediction of human pharmacokinetic parameters incorporating SMILES information	7
Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress	7
Engineered fibrotic liver-targeted truncated transforming growth factor β receptor type II variant for superior anti-liver fibrosis therapy	7
Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms	7
Physiologically based pharmacokinetic (PBPK) modeling of flurbiprofen in different CYP2C9 genotypes	7
Associations between the gut microbiota and the metabolism rate of tacrolimus in kidney transplant recipients during the early posttransplant period	7
Interplay between YAP/TAZ and metabolic dysfunction-associated steatotic liver disease progression	7
C-phycocyanin reinforces autophagy to block pulmonary fibrogenesis by inhibiting lncIAPF biogenesis	7