OOIR: Observatory of International Research

Papers

(The median citation count of Archives of Pharmacal Research is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Mouse models of nonalcoholic steatohepatitis and their application to new drug development	166
Ginsenoside-Rg2 exerts anti-cancer effects through ROS-mediated AMPK activation associated mitochondrial damage and oxidation in MCF-7 cells	132
Renal tubular PAR2 promotes interstitial fibrosis by increasing inflammatory responses and EMT process	95
Amyloidogenic, neuroinflammatory and memory dysfunction effects of HIV-1 gp120	65
CD48-expressing non-small-cell lung cancer cells are susceptible to natural killer cell–mediated cytotoxicity	64
Correction to: Recent advances in CRISPR technologies for genome editing	53
Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation	52
Osteogenic effect of an adiponectin-derived short peptide that rebalances bone remodeling: a potential disease-modifying approach for postmenopausal osteoporosis therapy	50
Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities	49
Correction to: The multifaceted role of STAT3 pathway and its implication as a potential therapeutic target in oral cancer	48
Donepezil improves skeletal muscle insulin resistance in obese mice via the AMPK/FGF21-mediated suppression of inflammation and ferroptosis	45
Anti-fibrotic effect of aurocyanide, the active metabolite of auranofin	44
Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions	43
Impact of binge drinking on alcoholic liver disease	40
Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration	40
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways	36
Retraction Note: Anti-inflammatory effect of atorvastatin on vascular reactivity and insulin resistance in fructose fed rats	36
Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway	35
Exosomal microRNAs as diagnostic and therapeutic biomarkers in non-malignant liver diseases	34
Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease mouse model: novel mechanistic insight	33
The role and application of transcriptional repressors in cancer treatment	32
Advances in plant-derived natural products for antitumor immunotherapy	32
Minor structural changes, major functional impacts: posttranslational modifications and drug targets	31
A review on bacteria-derived antioxidant metabolites: their production, purification, characterization, potential applications, and limitations	30
Non-alcoholic fatty liver disease and liver secretome	30

Isolation, structure elucidation, total synthesis, and biosynthesis of dermazolium A, an antibacterial imidazolium metabolite of a vaginal bacterium Dermabacter vaginalis	29
Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis	28
Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes	28
Effects of fluconazole on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes	27
Molecular epigenetic dynamics in breast carcinogenesis	26
Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation	26
Ginsenoside Rh1 inhibits tumor growth in MDA-MB-231 breast cancer cells via mitochondrial ROS and ER stress-mediated signaling pathway	26
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2	24
Triterpenoids from Dysoxylum genus and their biological activities	24
Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions	23
Anti-angiogenesis revisited: reshaping the treatment landscape of advanced non-small cell lung cancer	23
The inhibition of endothelial DLL4-NOTCH1 signaling by 2'-hydroxyflavanone enhances anti-PD-1 therapy in melanoma	22
Phytochemistry and pharmacology of plants in the genus Chaenomeles	21
Dapagliflozin attenuates myocardial remodeling in hypertension by activating the circadian rhythm signaling pathway	20
The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model	20
Immunosenescence and age-related immune cells: causes of age-related diseases	20
Discovery and synthesis of 1,2,4-oxadiazole derivatives as novel inhibitors of Zika, dengue, Japanese encephalitis, and classical swine fever virus infections	20
Predictive biomarkers for molecularly targeted therapies and immunotherapies in breast cancer	20
Pralsetinib: chemical and therapeutic development with FDA authorization for the management of RET fusion-positive non-small-cell lung cancers	20
Effects of CYP2C93 and 13 alleles on the pharmacokinetics and pharmacodynamics of glipizide in healthy Korean subjects	19
Correction to: Site-selective and metal-free C–H nitration of biologically relevant N-heterocycles	19
Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects	19
Physiologically based pharmacokinetic (PBPK) modeling for prediction of celecoxib pharmacokinetics according to CYP2C9 genetic polymorphism	18
Potential effects of a human milk oligosaccharide 6′-sialyllactose on angiotensin II-induced aortic aneurysm via p90RSK/TGF-β/SMAD2 signaling pathway	18
Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes	18
Biomedical features and therapeutic potential of rosmarinic acid	17
Potential of natural products in inflammation: biological activities, structure–activity relationships, and mechanistic targets	17
Immune-related pathogenesis and therapeutic strategies of nonalcoholic steatohepatitis	17
Akt-activated GSK3β inhibitory peptide effectively blocks tau hyperphosphorylation	16
Paeonia genus: a systematic review of active ingredients, pharmacological effects and mechanisms, and clinical applications for the treatment of cancer	16
Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone	16
New tricyclic systems as photosensitizers towards triple negative breast cancer cells	16
Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review	16
Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC	15
Advanced therapeutic strategies targeting microglia: beyond neuroinflammation	15
Biodegradable gelatin methacryloyl microneedles: a new paradigm in transdermal drug delivery	15
Cardiotoxicity linked to anticancer agents and cardioprotective strategy	15
Mechanistic insights and emerging therapeutic strategies targeting endothelial dysfunction in cardiovascular diseases	15
Inhibition of autophagy with chloroquine dysregulates mitochondrial quality control and energetics in adipocytes	14
Curcumin targets CXCL16-mediated podocyte injury and lipid accumulation in diabetic kidney disease treatment	14
Physiologically based pharmacokinetic (PBPK) modeling of pitavastatin in relation to SLCO1B1 genetic polymorphism	14
Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment	14
New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1)	14
Physiologically based pharmacokinetic (PBPK) modeling of piroxicam with regard to CYP2C9 genetic polymorphism	14
Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies	14
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells	13
Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose attenuate LPS-induced lung injury by inhibiting STAT1 and NF-κB signaling pathways	13
Inhibition of PI3K/mTOR/KATP channel blunts sodium thiosulphate preconditioning mediated cardioprotection against ischemia–reperfusion injury	13
Dual roles of myeloid-derived suppressor cells in various diseases: a review	13
PET tracer development for imaging α-synucleinopathies	13

Biological insights and therapeutic potential of Glycyrrhiza uralensis and its bioactive compounds: an updated review	13
Effects of CYP2D6*10 allele on the pharmacokinetics of tolperisone	13
Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides	12
Physiologically based pharmacokinetic modelling to predict the pharmacokinetics of metoprolol in different CYP2D6 genotypes	12
E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice	12
Physiologically based pharmacokinetic (PBPK) modeling of gliclazide for different genotypes of CYP2C9 and CYP2C19	12
Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals	12
Latest research progress on anticancer effect of baicalin and its aglycone baicalein	11
Effects of CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy subjects	11
Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function	11
Physiologically based pharmacokinetic modeling of candesartan related to CYP2C9 genetic polymorphism in adult and pediatric patients	11
Indole-3-acetic acid ameliorates dextran sulfate sodium-induced colitis via the ERK signaling pathway	10
Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1β and IL-4/MCP-1 signaling pathways	10
Modulating versatile pathways using a cleavable PEG shell and EGFR-targeted nanoparticles to deliver CRISPR-Cas9 and docetaxel for triple-negative breast cancer inhibition	10
Exploring NNMT: from metabolic pathways to therapeutic targets	10
Protection of the hematopoietic system against radiation-induced damage: drugs, mechanisms, and developments	10
Ionically bridged dexamethasone sodium phosphate–zinc–PLGA nanocomplex in alginate microgel for the local treatment of ulcerative colitis	10
Role of mitochondrial dynamics and mitophagy of vascular smooth muscle cell proliferation and migration in progression of atherosclerosis	10
Role of monocarboxylate transporter I/lactate dehydrogenase B-mediated lactate recycling in tamoxifen-resistant breast cancer cells	10
Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs	9
Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins	8
Apocynin abrogates methotrexate-induced nephrotoxicity: role of TLR4/NF-κB-p65/p38-MAPK, IL-6/STAT-3, PPAR-γ, and SIRT1/FOXO3 signaling pathways	8
Retraction Note: MiR-338-5p ameliorates pathological cardiac hypertrophy by targeting CAMKIIδ	8
New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis	8
Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management	8
Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms	8
Comparative evaluation of bioactive phytochemicals in Spinacia oleracea cultivated under greenhouse and open field conditions	8
Low-dose curcumin enhances hippocampal neurogenesis and memory retention in young mice	8
Antitumor activity of Polygonatum sibiricum polysaccharides	8
mRNA vaccines: the most recent clinical applications of synthetic mRNA	8
Physiologically based pharmacokinetic (PBPK) modeling to predict the pharmacokinetics of irbesartan in different CYP2C9 genotypes	7
Is loss of smell an early predictor of COVID-19 severity: a systematic review and meta-analysis	7
Physiologically based pharmacokinetic (PBPK) modeling of flurbiprofen in different CYP2C9 genotypes	7
Targeting dysregulated lipid metabolism in the tumor microenvironment	7
Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress	7
PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes	7
Interplay between YAP/TAZ and metabolic dysfunction-associated steatotic liver disease progression	7
Prediction of human pharmacokinetic parameters incorporating SMILES information	7
C-phycocyanin reinforces autophagy to block pulmonary fibrogenesis by inhibiting lncIAPF biogenesis	7
Associations between the gut microbiota and the metabolism rate of tacrolimus in kidney transplant recipients during the early posttransplant period	7
Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine	7
Saponins as potential novel NLRP3 inflammasome inhibitors for inflammatory disorders	7
Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway	7
Methamphetamine-induced dopaminergic neurotoxicity as a model of Parkinson’s disease	7
Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells	7
Engineered fibrotic liver-targeted truncated transforming growth factor β receptor type II variant for superior anti-liver fibrosis therapy	7