OOIR: Observatory of International Research

Papers

(The TQCC of Archives of Pharmacal Research is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Renal tubular PAR2 promotes interstitial fibrosis by increasing inflammatory responses and EMT process	210
Evaluation of bone health and fracture risk in type 2 diabetes: a network meta-analysis of anti-diabetic treatments versus placebo	158
Mouse models of nonalcoholic steatohepatitis and their application to new drug development	80
CD48-expressing non-small-cell lung cancer cells are susceptible to natural killer cell–mediated cytotoxicity	75
Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation	64
Osteogenic effect of an adiponectin-derived short peptide that rebalances bone remodeling: a potential disease-modifying approach for postmenopausal osteoporosis therapy	58
Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities	55
Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway	54
Correction to: The multifaceted role of STAT3 pathway and its implication as a potential therapeutic target in oral cancer	54
Germacrane and humulane sesquiterpenes from the roots and rhizomes of Valeriana officinalis var. latifolia and their anti-inflammatory and anti-influenza virus activities	50
Impact of binge drinking on alcoholic liver disease	47
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways	43
Anti-fibrotic effect of aurocyanide, the active metabolite of auranofin	40
Retraction Note: Anti-inflammatory effect of atorvastatin on vascular reactivity and insulin resistance in fructose fed rats	40
Advances in plant-derived natural products for antitumor immunotherapy	38
Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease mouse model: novel mechanistic insight	37
Donepezil improves skeletal muscle insulin resistance in obese mice via the AMPK/FGF21-mediated suppression of inflammation and ferroptosis	37
Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions	36
Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration	36
The role and application of transcriptional repressors in cancer treatment	33
Isolation, structure elucidation, total synthesis, and biosynthesis of dermazolium A, an antibacterial imidazolium metabolite of a vaginal bacterium Dermabacter vaginalis	33
Minor structural changes, major functional impacts: posttranslational modifications and drug targets	32
Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis	32
Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes	31
Non-alcoholic fatty liver disease and liver secretome	31

A review on bacteria-derived antioxidant metabolites: their production, purification, characterization, potential applications, and limitations	30
Effects of fluconazole on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes	28
Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation	27
Ginsenoside Rh1 inhibits tumor growth in MDA-MB-231 breast cancer cells via mitochondrial ROS and ER stress-mediated signaling pathway	26
Anti-angiogenesis revisited: reshaping the treatment landscape of advanced non-small cell lung cancer	25
Triterpenoids from Dysoxylum genus and their biological activities	25
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2	24
Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions	24
Phytochemistry and pharmacology of plants in the genus Chaenomeles	23
Discovery and synthesis of 1,2,4-oxadiazole derivatives as novel inhibitors of Zika, dengue, Japanese encephalitis, and classical swine fever virus infections	23
The inhibition of endothelial DLL4-NOTCH1 signaling by 2'-hydroxyflavanone enhances anti-PD-1 therapy in melanoma	23
Predictive biomarkers for molecularly targeted therapies and immunotherapies in breast cancer	23
Immunosenescence and age-related immune cells: causes of age-related diseases	22
The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model	22
Dapagliflozin attenuates myocardial remodeling in hypertension by activating the circadian rhythm signaling pathway	22
Pralsetinib: chemical and therapeutic development with FDA authorization for the management of RET fusion-positive non-small-cell lung cancers	21
Correction to: Site-selective and metal-free C–H nitration of biologically relevant N-heterocycles	20
Potential effects of a human milk oligosaccharide 6′-sialyllactose on angiotensin II-induced aortic aneurysm via p90RSK/TGF-β/SMAD2 signaling pathway	20
Effects of CYP2C93 and 13 alleles on the pharmacokinetics and pharmacodynamics of glipizide in healthy Korean subjects	20
Potential of natural products in inflammation: biological activities, structure–activity relationships, and mechanistic targets	20
Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review	19
Immune-related pathogenesis and therapeutic strategies of nonalcoholic steatohepatitis	19
Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes	19
New tricyclic systems as photosensitizers towards triple negative breast cancer cells	19
Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects	19
Akt-activated GSK3β inhibitory peptide effectively blocks tau hyperphosphorylation	19
Biomedical features and therapeutic potential of rosmarinic acid	19
Biodegradable gelatin methacryloyl microneedles: a new paradigm in transdermal drug delivery	18
Inhibition of autophagy with chloroquine dysregulates mitochondrial quality control and energetics in adipocytes	18
Paeonia genus: a systematic review of active ingredients, pharmacological effects and mechanisms, and clinical applications for the treatment of cancer	18
Cardiotoxicity linked to anticancer agents and cardioprotective strategy	18
New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1)	18
Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone	18
Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC	18
Advanced therapeutic strategies targeting microglia: beyond neuroinflammation	18