OOIR: Observatory of International Research

Papers

(The TQCC of Archives of Pharmacal Research is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Mouse models of nonalcoholic steatohepatitis and their application to new drug development	234
Evaluation of bone health and fracture risk in type 2 diabetes: a network meta-analysis of anti-diabetic treatments versus placebo	167
Renal tubular PAR2 promotes interstitial fibrosis by increasing inflammatory responses and EMT process	91
Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation	77
Osteogenic effect of an adiponectin-derived short peptide that rebalances bone remodeling: a potential disease-modifying approach for postmenopausal osteoporosis therapy	69
Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities	63
Correction to: The multifaceted role of STAT3 pathway and its implication as a potential therapeutic target in oral cancer	61
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways	57
Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration	56
Anti-fibrotic effect of aurocyanide, the active metabolite of auranofin	53
Donepezil improves skeletal muscle insulin resistance in obese mice via the AMPK/FGF21-mediated suppression of inflammation and ferroptosis	46
Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway	41
Impact of binge drinking on alcoholic liver disease	40
Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease mouse model: novel mechanistic insight	40
Retraction Note: Anti-inflammatory effect of atorvastatin on vascular reactivity and insulin resistance in fructose fed rats	39
Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions	38
Germacrane and humulane sesquiterpenes from the roots and rhizomes of Valeriana officinalis var. latifolia and their anti-inflammatory and anti-influenza virus activities	38
Isolation, structure elucidation, total synthesis, and biosynthesis of dermazolium A, an antibacterial imidazolium metabolite of a vaginal bacterium Dermabacter vaginalis	37
Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis	37
Non-alcoholic fatty liver disease and liver secretome	33
The role and application of transcriptional repressors in cancer treatment	32
A review on bacteria-derived antioxidant metabolites: their production, purification, characterization, potential applications, and limitations	31
Minor structural changes, major functional impacts: posttranslational modifications and drug targets	31
Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes	29
Effects of fluconazole on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes	28

Ginsenoside Rh1 inhibits tumor growth in MDA-MB-231 breast cancer cells via mitochondrial ROS and ER stress-mediated signaling pathway	27
Triterpenoids from Dysoxylum genus and their biological activities	27
Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation	27
Anti-angiogenesis revisited: reshaping the treatment landscape of advanced non-small cell lung cancer	26
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2	26
The inhibition of endothelial DLL4-NOTCH1 signaling by 2'-hydroxyflavanone enhances anti-PD-1 therapy in melanoma	26
Salvianolic acid A enhances Treg accumulation via the RUNX1/CBFβ/FOXP3 axis as a neuroprotective immunomodulator in ischemic stroke	25
Phytochemistry and pharmacology of plants in the genus Chaenomeles	24
Pralsetinib: chemical and therapeutic development with FDA authorization for the management of RET fusion-positive non-small-cell lung cancers	23
The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model	23
Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions	23
Dapagliflozin attenuates myocardial remodeling in hypertension by activating the circadian rhythm signaling pathway	22
Discovery and synthesis of 1,2,4-oxadiazole derivatives as novel inhibitors of Zika, dengue, Japanese encephalitis, and classical swine fever virus infections	22
Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes	21
Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects	21
Immunosenescence and age-related immune cells: causes of age-related diseases	21
Predictive biomarkers for molecularly targeted therapies and immunotherapies in breast cancer	21
Potential effects of a human milk oligosaccharide 6′-sialyllactose on angiotensin II-induced aortic aneurysm via p90RSK/TGF-β/SMAD2 signaling pathway	21
Potential of natural products in inflammation: biological activities, structure–activity relationships, and mechanistic targets	21
Biomedical features and therapeutic potential of rosmarinic acid	20
Akt-activated GSK3β inhibitory peptide effectively blocks tau hyperphosphorylation	20
Paeonia genus: a systematic review of active ingredients, pharmacological effects and mechanisms, and clinical applications for the treatment of cancer	20
Immune-related pathogenesis and therapeutic strategies of nonalcoholic steatohepatitis	20
New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1)	19
New tricyclic systems as photosensitizers towards triple negative breast cancer cells	19
Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC	19
Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review	19
Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone	19
Advanced therapeutic strategies targeting microglia: beyond neuroinflammation	17
Advances and challenges of estrogen receptor-targeted agents in breast cancer	17
Inhibition of autophagy with chloroquine dysregulates mitochondrial quality control and energetics in adipocytes	17
Cardiotoxicity linked to anticancer agents and cardioprotective strategy	16