OOIR: Observatory of International Research

Papers

(The TQCC of Archives of Pharmacal Research is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Discovery of novel naphthalene-based diarylamides as pan-Raf kinase inhibitors with promising anti-melanoma activity: rational design, synthesis, in vitro and in silico screening	147
Review on pharmacological effects of gastrodin	126
Tumor lactic acid: a potential target for cancer therapy	124
CD48-expressing non-small-cell lung cancer cells are susceptible to natural killer cell–mediated cytotoxicity	88
Amyloidogenic, neuroinflammatory and memory dysfunction effects of HIV-1 gp120	60
Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine	59
Androgen receptor and hyaluronan-mediated motility receptor as new molecular targets of baicalein: new molecular mechanisms for its anticancer properties	47
Effects of CYP2D6*10 allele on the pharmacokinetics of tolperisone	46
Recent advances in CRISPR technologies for genome editing	46
Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions	45
Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose attenuate LPS-induced lung injury by inhibiting STAT1 and NF-κB signaling pathways	45
Ginkwanghols A and B, osteogenic coumaric acid-aliphatic alcohol hybrids from the leaves of Ginkgo biloba	44
Physiologically based pharmacokinetic modelling to predict the pharmacokinetics of metoprolol in different CYP2D6 genotypes	43
Phytochemistry and pharmacology of plants in the genus Chaenomeles	42
Ginsenoside-Rg2 exerts anti-cancer effects through ROS-mediated AMPK activation associated mitochondrial damage and oxidation in MCF-7 cells	41
Inhibition of PI3K/mTOR/KATP channel blunts sodium thiosulphate preconditioning mediated cardioprotection against ischemia–reperfusion injury	38
Complicity of α-synuclein oligomer and calcium dyshomeostasis in selective neuronal vulnerability in Lewy body disease	37
Interplay between YAP/TAZ and metabolic dysfunction-associated steatotic liver disease progression	36
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells	34
Mouse models of nonalcoholic steatohepatitis and their application to new drug development	34
Dual roles of myeloid-derived suppressor cells in various diseases: a review	31
Distinctive role of inflammation in tissue repair and regeneration	30
Ginsenoside Rg3 activates the immune function of CD8+ T cells via circFOXP1-miR-4477a-PD-L1 axis to induce ferroptosis in gallbladder cancer	30
The role of mucosal barriers in human gut health	30
Is loss of smell an early predictor of COVID-19 severity: a systematic review and meta-analysis	29

Renal tubular PAR2 promotes interstitial fibrosis by increasing inflammatory responses and EMT process	29
Combination therapy involving HSP90 inhibitors for combating cancer: an overview of clinical and preclinical progress	28
Atractylenolides (I, II, and III): a review of their pharmacology and pharmacokinetics	26
Biological insights and therapeutic potential of Glycyrrhiza uralensis and its bioactive compounds: an updated review	25
Immunosenescence and age-related immune cells: causes of age-related diseases	24
Pralsetinib: chemical and therapeutic development with FDA authorization for the management of RET fusion-positive non-small-cell lung cancers	24
Physiologically based pharmacokinetic (PBPK) modeling to predict the pharmacokinetics of irbesartan in different CYP2C9 genotypes	24
Correction to: Recent advances in CRISPR technologies for genome editing	24
The novel psychoactive substance 25E-NBOMe induces reward-related behaviors via dopamine D1 receptor signaling in male rodents	24
Artemongolins A–K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities	23
Discovery and synthesis of 1,2,4-oxadiazole derivatives as novel inhibitors of Zika, dengue, Japanese encephalitis, and classical swine fever virus infections	23
Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation	23
Comparative metabolism of aschantin in human and animal hepatocytes	22
Stabilization of RNA G-quadruplexes in the SARS-CoV-2 genome inhibits viral infection via translational suppression	22
Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities	21
Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives	21
Dapagliflozin attenuates myocardial remodeling in hypertension by activating the circadian rhythm signaling pathway	20
E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice	20
Inhibitory effects of 6′-sialyllactose on angiotensin II-induced proliferation, migration, and osteogenic switching in vascular smooth muscle cells	19
Osteogenic effect of an adiponectin-derived short peptide that rebalances bone remodeling: a potential disease-modifying approach for postmenopausal osteoporosis therapy	19
The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model	19
Engineered fibrotic liver-targeted truncated transforming growth factor β receptor type II variant for superior anti-liver fibrosis therapy	19
PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes	18
Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides	18
Potential biological functions and future perspectives of sialylated milk oligosaccharides	18
Predictive biomarkers for molecularly targeted therapies and immunotherapies in breast cancer	18
COVID-19 and pulmonary fibrosis: therapeutics in clinical trials, repurposing, and potential development	18
PBPK modeling to predict the pharmacokinetics of venlafaxine and its active metabolite in different CYP2D6 genotypes and drug–drug interactions with clarithromycin and paroxetine	18
Isoindolin-1-ones from the stems of Nicotiana tabacum and their antiviral activities	18