OOIR: Observatory of International Research

Papers

(The TQCC of Archives of Pharmacal Research is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Ubiquitin–proteasome system (UPS) as a target for anticancer treatment	154
Phytochemistry and pharmacological activity of the genus artemisia	86
The pharmacological and biological roles of eriodictyol	78
Pathological angiogenesis and inflammation in tissues	64
Mechanisms of resistance to chemotherapy in non-small cell lung cancer	63
Aldose Reductase: a cause and a potential target for the treatment of diabetic complications	62
Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases	60
Biomedical features and therapeutic potential of rosmarinic acid	56
Skin barrier dysfunction and filaggrin	54
Pharmacological effects of harmine and its derivatives: a review	54
Overview of COVID-19 inflammatory pathogenesis from the therapeutic perspective	51
Astragalus polysaccharide: a review of its immunomodulatory effect	50
Small molecule tyrosine kinase inhibitors in glioblastoma	49
Empagliflozin alleviates neuronal apoptosis induced by cerebral ischemia/reperfusion injury through HIF-1α/VEGF signaling pathway	46
Phytochemical and pharmacological properties of Myristica fragrans Houtt.: an updated review	41
Ginkwanghols A and B, osteogenic coumaric acid-aliphatic alcohol hybrids from the leaves of Ginkgo biloba	39
The potential health benefits of the isoflavone glycoside genistin	38
Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes	38
A pursuit of Staphylococcus aureus continues: a role of persister cells	37
Flavonoids as therapeutic candidates for emotional disorders such as anxiety and depression	36
Role of specialized pro-resolving lipid mediators and their receptors in virus infection: a promising therapeutic strategy for SARS-CoV-2 cytokine storm	36
Hydroxychloroquine and chloroquine: a potential and controversial treatment for COVID-19	35
Emerging roles of ferroptosis in liver pathophysiology	35
Understanding of sarcopenia: from definition to therapeutic strategies	34
Recent insights on modulation of inflammasomes by adipokines: a critical event for the pathogenesis of obesity and metabolism-associated diseases	33

Crosstalk between angiogenesis and immune regulation in the tumor microenvironment	32
The role of mucosal barriers in human gut health	32
Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway	31
The role of epithelial–mesenchymal transition-regulating transcription factors in anti-cancer drug resistance	29
Role of autophagy in regulation of cancer cell death/apoptosis during anti-cancer therapy: focus on autophagy flux blockade	29
Is loss of smell an early predictor of COVID-19 severity: a systematic review and meta-analysis	28
Recent advances in the pathology of prodromal non-motor symptoms olfactory deficit and depression in Parkinson’s disease: clues to early diagnosis and effective treatment	28
Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action	28
Role of mitochondrial dynamics and mitophagy of vascular smooth muscle cell proliferation and migration in progression of atherosclerosis	27
mRNA vaccines: the most recent clinical applications of synthetic mRNA	27
Fibroblast growth factor 2 exacerbates inflammation in adipocytes through NLRP3 inflammasome activation	26
Ginsenoside-Rg2 exerts anti-cancer effects through ROS-mediated AMPK activation associated mitochondrial damage and oxidation in MCF-7 cells	26
Therapeutic effects of ginsenosides on breast cancer growth and metastasis	26
Evaluation and live monitoring of pH-responsive HSA-ZnO nanoparticles using a lung-on-a-chip model	25
Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides	25
Pharmacokinetics of ginsenosides following repeated oral administration of red ginseng extract significantly differ between species of experimental animals	25
Effects of CYP2D6 genetic polymorphism on the pharmacokinetics of metoclopramide	24
Atractylenolides (I, II, and III): a review of their pharmacology and pharmacokinetics	24
Physiologically based pharmacokinetic (PBPK) modeling for prediction of celecoxib pharmacokinetics according to CYP2C9 genetic polymorphism	23
Curcumin derivatives for Type 2 Diabetes management and prevention of complications	23
3D-quantitative structure–activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase	23
The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenance	22
New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1)	22
Latest research progress on anticancer effect of baicalin and its aglycone baicalein	22
LncRNA AIRN influences the proliferation and apoptosis of hepatocellular carcinoma cells by regulating STAT1 ubiquitination	22
White matter and neurological disorders	20
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells	20
Antimicrobial compounds from marine actinomycetes	20
Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives	20
Recent progress in development and applications of second near‐infrared (NIR-II) nanoprobes	20
NRF2 level is negatively correlated with TGF-β1-induced lung cancer motility and migration via NOX4-ROS signaling	20
ABCB1 c.2677G>T/c.3435C>T diplotype increases the early-phase oral absorption of losartan	19
Qi-activating quercetin alleviates mitochondrial dysfunction and neuroinflammation in vivo and in vitro	19
Comparative evaluation of bioactive phytochemicals in Spinacia oleracea cultivated under greenhouse and open field conditions	19
Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells	19
Ferulic acid protects cardiomyocytes from TNF-α/cycloheximide-induced apoptosis by regulating autophagy	19
Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway	18
Antibody–drug conjugates and bispecific antibodies targeting cancers: applications of click chemistry	18
Blood-brain barrier dysfunction as a potential therapeutic target for neurodegenerative disorders	18
Targeting fatty acid metabolism for fibrotic disorders	17
Structure elucidation of small organic molecules by contemporary computational chemistry methods	17
Exosomal microRNAs as diagnostic and therapeutic biomarkers in non-malignant liver diseases	17
Protective effect of quercetin against myocardial ischemia as a Ca2+ channel inhibitor: involvement of inhibiting contractility and Ca2+ influx via L-type Ca2+ channels	17
Fucoidan inhibits LPS-induced acute lung injury in mice through regulating GSK-3β-Nrf2 signaling pathway	17
β-Sitosterol attenuates liver injury in a rat model of chronic alcohol intake	17