OOIR: Observatory of International Research

Papers

(The TQCC of Archives of Pharmacal Research is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Mouse models of nonalcoholic steatohepatitis and their application to new drug development	166
Ginsenoside-Rg2 exerts anti-cancer effects through ROS-mediated AMPK activation associated mitochondrial damage and oxidation in MCF-7 cells	132
Renal tubular PAR2 promotes interstitial fibrosis by increasing inflammatory responses and EMT process	95
Amyloidogenic, neuroinflammatory and memory dysfunction effects of HIV-1 gp120	65
CD48-expressing non-small-cell lung cancer cells are susceptible to natural killer cell–mediated cytotoxicity	64
Correction to: Recent advances in CRISPR technologies for genome editing	53
Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation	52
Osteogenic effect of an adiponectin-derived short peptide that rebalances bone remodeling: a potential disease-modifying approach for postmenopausal osteoporosis therapy	50
Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities	49
Correction to: The multifaceted role of STAT3 pathway and its implication as a potential therapeutic target in oral cancer	48
Donepezil improves skeletal muscle insulin resistance in obese mice via the AMPK/FGF21-mediated suppression of inflammation and ferroptosis	45
Anti-fibrotic effect of aurocyanide, the active metabolite of auranofin	44
Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions	43
Impact of binge drinking on alcoholic liver disease	40
Challenges and opportunities of developing small-molecule therapies for age-related macular degeneration	40
Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways	36
Retraction Note: Anti-inflammatory effect of atorvastatin on vascular reactivity and insulin resistance in fructose fed rats	36
Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway	35
Exosomal microRNAs as diagnostic and therapeutic biomarkers in non-malignant liver diseases	34
Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease mouse model: novel mechanistic insight	33
The role and application of transcriptional repressors in cancer treatment	32
Advances in plant-derived natural products for antitumor immunotherapy	32
Minor structural changes, major functional impacts: posttranslational modifications and drug targets	31
A review on bacteria-derived antioxidant metabolites: their production, purification, characterization, potential applications, and limitations	30
Non-alcoholic fatty liver disease and liver secretome	30

Isolation, structure elucidation, total synthesis, and biosynthesis of dermazolium A, an antibacterial imidazolium metabolite of a vaginal bacterium Dermabacter vaginalis	29
Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis	28
Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes	28
Effects of fluconazole on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes	27
Ginsenoside Rh1 inhibits tumor growth in MDA-MB-231 breast cancer cells via mitochondrial ROS and ER stress-mediated signaling pathway	26
Molecular epigenetic dynamics in breast carcinogenesis	26
Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation	26
Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2	24
Triterpenoids from Dysoxylum genus and their biological activities	24
Anti-angiogenesis revisited: reshaping the treatment landscape of advanced non-small cell lung cancer	23
Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions	23
The inhibition of endothelial DLL4-NOTCH1 signaling by 2'-hydroxyflavanone enhances anti-PD-1 therapy in melanoma	22
Phytochemistry and pharmacology of plants in the genus Chaenomeles	21
Pralsetinib: chemical and therapeutic development with FDA authorization for the management of RET fusion-positive non-small-cell lung cancers	20
Dapagliflozin attenuates myocardial remodeling in hypertension by activating the circadian rhythm signaling pathway	20
The effects of BRL-50481 on ovalbumin-induced asthmatic lung inflammation exacerbated by co-exposure to Asian sand dust in the murine model	20
Immunosenescence and age-related immune cells: causes of age-related diseases	20
Discovery and synthesis of 1,2,4-oxadiazole derivatives as novel inhibitors of Zika, dengue, Japanese encephalitis, and classical swine fever virus infections	20
Predictive biomarkers for molecularly targeted therapies and immunotherapies in breast cancer	20
Effects of CYP2C93 and 13 alleles on the pharmacokinetics and pharmacodynamics of glipizide in healthy Korean subjects	19
Correction to: Site-selective and metal-free C–H nitration of biologically relevant N-heterocycles	19
Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects	19
Physiologically based pharmacokinetic (PBPK) modeling for prediction of celecoxib pharmacokinetics according to CYP2C9 genetic polymorphism	18
Potential effects of a human milk oligosaccharide 6′-sialyllactose on angiotensin II-induced aortic aneurysm via p90RSK/TGF-β/SMAD2 signaling pathway	18
Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes	18
Biomedical features and therapeutic potential of rosmarinic acid	17
Potential of natural products in inflammation: biological activities, structure–activity relationships, and mechanistic targets	17
Immune-related pathogenesis and therapeutic strategies of nonalcoholic steatohepatitis	17
Antibacterial properties of natural products from marine fungi reported between 2012 and 2023: a review	16
Akt-activated GSK3β inhibitory peptide effectively blocks tau hyperphosphorylation	16
Paeonia genus: a systematic review of active ingredients, pharmacological effects and mechanisms, and clinical applications for the treatment of cancer	16
Effects of CYP2D6 and CYP2C19 genetic polymorphisms and cigarette smoking on the pharmacokinetics of tolperisone	16
New tricyclic systems as photosensitizers towards triple negative breast cancer cells	16