OOIR: Observatory of International Research

Papers

(The TQCC of Immunologic Research is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
The effect of mutatio-type on proteo-phenotype and clinico-phenotype in selected primary immunodeficiencies	59
Somatic hypermutation defects in two adult hyper immunoglobulin M patients	58
B cell repertoire in patients with a novel BTK mutation: expanding the spectrum of atypical X-linked agammaglobulinemia	58
MiR-29a-3p negatively regulates circulating Tfh memory cells in patients with Graves’ disease by targeting ICOS	57
Rapid generation of an RBL cellular model to study proteins that cause allergenic reactions in vitro	52
Quantitative evaluation of citrullinated fibrinogen for detection of neutrophil extracellular traps	50
Genetic variability of three common NK and γδ T cell receptor genes (FCγ3R, NCR3, and DNAM-1) and their role in Polish patients with rheumatoid arthritis and ankylosing spondylitis	39
Belimumab 10 years later: how drug positioning has changed	38
A case of atypical infantile de novo antiphospholipid syndrome presenting with neonatal ischemic stroke without any triggering risk factors as a “second hit” and review of the literature	37
Role of booster with BNT162b2 mRNA in SARS-CoV-2 vaccination in patients with rheumatoid arthritis	34
Laboratory and clinical practices in antinuclear antibody detection and related antigens: recommendations from a Spanish multicentre survey	32
Macrophage subsets and their role: co-relation with colony-stimulating factor-1 receptor and clinical relevance	32
Hypoxia modulates human mast cell adhesion to hyaluronic acid	27
[Cuproptosis-related immune gene signature predicts clinical benefits from anti-PD-1/PD-L1 therapy in non-small-cell lung cancer	25
A ubiquitin–proteasome system-related signature to predict prognosis, immune infiltration, and therapy efficacy for breast cancer	24
ANCA detection with solid phase chemiluminescence assay: diagnostic and severity association in vasculitis	24
Manipulation of the tumor immuno-microenvironment via TAM-targeted expression of transcription factors	24
Clinical relevance and frequency of cytoplasmic patterns observed in ANA-Hep-2: experience of Cairo University Hospitals	22
Immune tumoral microenvironment in gliomas: focus on CD3+ T cells, Vδ1+ T cells, and microglia/macrophages	21
Activation of autophagy reverses gemcitabine-induced immune inhibition of RAW264.7 macrophages by promoting TNF-α, IL-6 and MHC-II expression	21
Lipocalin 2—not only a biomarker: a study of current literature and systematic findings of ongoing clinical trials	21
CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis	20
Correction: Major histocompatibility complex class I molecule expression by pancreatic cancer cells is regulated by activation and inhibition of the epidermal growth factor receptor	18
Bergamottin protects against LPS-induced endotoxic shock by regulating the NF-κB signaling pathway	18
B-cell activating factor BAFF as a novel alert marker for the immunological risk stratification after kidney transplantation	17

A patient with RFX5 variant causing an expression defect in both HLA ABC and HLA DR	17
The Janus kinase inhibitor (baricitinib) suppresses the rheumatoid arthritis active marker gliostatin/thymidine phosphorylase in human fibroblast-like synoviocytes	16
T cell receptor clonotype in tumor microenvironment contributes to intratumoral signaling network in patients with colorectal cancer	16
Juvenile dermatomyositis associated with autoantibodies to small ubiquitin-like modifier activating enzyme: a report of 4 cases from North India and a review of literature	16
Potential therapeutic strategies for myocardial infarction: the role of Toll-like receptors	16
The expression of CD86 in CD3+CD56+ NKT cells is associated with the occurrence and prognosis of sepsis-associated encephalopathy in sepsis patients: a prospective observational cohort study	15
Semaphorin 3 a restores the ability of type 1 regulatory T cells to suppress food allergy	15
Association of IL-23R and IL-10 variations with Behçet disease: a genetic analysis study	15
Dominance and improved survivability of human γδT17 cell subset aggravates the immunopathogenesis of pemphigus vulgaris	15
Tryptanthrin attenuates TLR3-mediated STAT1 activation in THP-1 cells	14
Clinical and molecular profile of 20 patients with DOCK8 deficiency—a single-center experience from Southern India	14
Pan-genome and reverse vaccinology approaches to design multi-epitope vaccine against Epstein-Barr virus associated with colorectal cancer	14
Efficacy and safety of IL-23 inhibitors in the treatment of psoriatic arthritis: a meta-analysis based on randomized controlled trials	13
Melatonin: a potential therapeutic approach for the management of primary Sjögren’s syndrome	13
Thyroid receptor β might be responsible for breast cancer associated with Hashimoto’s thyroiditis: a new insight into pathogenesis	12
Post-translational modification in the pathogenesis of vitiligo	12
Impaired inducibility of immune regulatory capacity of peripheral B cells of patients with recurrent pregnancy loss	11
Expression of O-glycosylated oncofetal fibronectin in alternatively activated human macrophages	11
Extracellular vesicle–encapsulated miR-10a-5p derived from MDSCs restrains germinal center B cells in experimental Sjögren’s syndrome	11
Case report: Synergistic defects of CASP10 and BTK leading to autoimmune lymphoproliferative syndrome type IIa, complicated by severe hemophagocytic lymphohistiocytosis	11
miR-141-3p attenuates inflammation and oxidative stress–induced pulmonary fibrosis in ARDS via the Keap1/Nrf2/ARE signaling pathway	11
The urease E subunit vaccine stimulate the immune response versus Helicobacter pylori in animal model	11
Amphibian cellular immune response to chytridiomycosis at metamorphic climax	10
Current genetic defects in common variable immunodeficiency patients on the geography between Europe and Asia: a single-center experience	10
High mobility group box 1 (HMGB1) inhibition attenuates lipopolysaccharide-induced cognitive dysfunction and sickness-like behavior in mice	10
Translational and structural vaccinomics approach to design a multi-epitope vaccine against NOL4 autologous antigen of small cell lung cancer	10
Reactivity of DENV-positive sera against recombinant envelope proteins produced in bacteria and eukaryotic cells	9
Inhibition of cIAP1/2 reduces RIPK1 phosphorylation in pulmonary endothelial cells and alleviate sepsis-induced lung injury and inflammatory response	9
Comparison of artificial intelligence applications and commercial system performances using selected ANA IIF images	9
Coexistence of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and IgA nephropathy	9
Increased synthesis and intestinal expression of IL-39 in patients with inflammatory bowel disease	9
Immunomodulatory effects of alexidine dihydrochloride on mammalian macrophages through the modulation of the JNK pathway	9
Insights into inflammasome regulation: cellular, molecular, and pathogenic control of inflammasome activation	9
Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses — a randomized, placebo-controlled clinical trial	9
Discouraging Non-ELISA antiphospholipid antibody assays in antiphospholipid syndrome classification may hinder clinical research	9
Integrative bioinformatics and experimental analyses identify U2SURP as a novel lactylation-related prognostic signature in esophageal carcinoma	8
In vitro treatment of triple-negative breast cancer cells with an extract from the Coriolus versicolor mushroom changes macrophage properties related to tumourigenesis	8
Utility of simultaneous quantification of TREC/KREC in patients with common variable immunodeficiency phenotype: an observational study from North India	8
mTOR-mediated differentiation and maintenance of suppressive T cells at the center stage of IPEX treatment	8
SARS-CoV-2 antibodies in inflammatory neurological conditions: a multicentre retrospective comparative study	8
DMRT3-mediated lncRNA OIP5-AS1 promotes the pyroptosis of bronchial epithelial cells by binding with EIF4A3 to enhance YAP mRNA stability	8
Retinoic acid increases the cellular cholesterol predominantly in a mTOR-independent manner	8
Regnase-1 regulates inflammation in T cells of ankylosing spondylitis through the TRAF6	8
Fructus lycii oligosaccharide alleviates acute liver injury via PI3K/Akt/mTOR pathway	7
The effect of the BNT162b2 vaccine on antinuclear antibody and antiphospholipid antibody levels	7
Autophagic reprogramming of bone marrow–derived macrophages	7
Predictive biomarkers of response to tocilizumab in giant cell arteritis (GCA): correlations with imaging activity	7
Anti-complement factor H (CFH) autoantibodies could delay pristane-induced lupus nephritis	7
New-onset eosinophilic granulomatosis with polyangiitis in 2 patients during treatment with IL-5 pathway inhibitors	7
Phillyrin inhibits oxidative stress and neutrophil extracellular trap formation through the KEAP1/NRF2 pathway in gouty arthritis	7

Identification of nafamostat mesylate as a selective stimulator of NK cell IFN-γ production via metabolism-related compound library screening	7
Mass cytometry revealed the circulating immune cell landscape across different Suzuki stages of Moyamoya disease	6
Analysis of inflammation-related microRNA expression in patients with ankylosing spondylitis	6
An association study on the risk, glucocorticoids effectiveness, and prognosis of systemic lupus erythematosus: insight from mitochondrial DNA copy number	6
CCR2+TREM-1+ monocytes promote natural killer T cell dysfunction contributing towards HBV disease progression	6
Conventional Tregs in treatment-naïve rheumatoid arthritis are deficient in suppressive function with an increase in percentage of CXCR3 and CCR6 expressing Tregs	6
Recurrent high fever with macular papules in an elderly male: a case report	6
Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions	6
Correction to: A latent pathogen infection classification system that would significantly increase healthcare safety	6
Exploring CCR5 + T regulatory cell subset dysfunction in type 1 diabetes patients: implications for immune regulation	6
Investigation of T lymphocyte subsets in children with Mycoplasma pneumoniae pneumonia	6
Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis	6
A short focus, azithromycin in the treatment of respiratory viral infection COVID-19: efficacy or inefficacy?	6
Autoimmune lymphoproliferative syndrome (ALPS) due to a novel dominant negative germline mutation in the FAS gene	6
Circular RNA hsa_circ_0001598 promotes programmed death-ligand-1-mediated immune escape and trastuzumab resistance via sponging miR-1184 in breast cancer cells	5
Polyethylene glycol and immunology: aspects of allergic reactions and their mechanisms, as well as ways to prevent them in clinical practice	5
A novel loss of function mutation in the HAVCR2 gene in a patient diagnosed with Hodgkin’s lymphoma	5
The function of CD8 + T cells in the absence of MHC-I in target cells: what to learn from the deficiency of MHC-I expression in humans	5
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice	5
An overview of the biological and multifunctional roles of IL-38 in different infectious diseases and COVID-19	5
Thymic tuft cells: potential “regulators” of non-mucosal tissue development and immune response	5
Lower frequency of T stem cell memory (TSCM) cells in hepatitis B vaccine nonresponders	5
Vitamin D receptor gene polymorphisms are associated with the risk and features of myasthenia gravis in the Han Chinese population	5
Analysis of PD-1, PD-L1, and T-cell infiltration in angiosarcoma pathogenetic subgroups	5
The prognostic value of IgA anti-citrullinated protein antibodies and rheumatoid factor in an early arthritis population with a treat-to-target approach	5
Clinical profile and management of pediatric hereditary angioedema in resource-constrained settings: our experience from a single centre in North India	5
HLA-E-expressing macrophage polarization and increased NKG2A/CD94 expression in adult-onset Still’s disease	5
Peripheral distributions of IL-4-producing CD4 + T cells and CD4 + CD25 + FoxP3 + T cells (Tregs) in rheumatoid arthritis patients with poor response to therapy are associated with HLA shared epitope	4
Involvement of gut microbiota in multiple sclerosis—review of a new pathophysiological hypothesis and potential treatment target	4
Versatile roles for neutrophil proteinase 3 in hematopoiesis and inflammation	4
A latent pathogen infection classification system that would significantly increase healthcare safety	4
Insights into the immunological description of cryoglobulins with regard to detection and characterization in Slovenian rheumatological patients	4
Monophosphoryl lipid A as a co-adjuvant in methicillin-resistant Staphylococcus aureus vaccine development: improvement of immune responses in a mouse model of infection	4
The alterations of cerebrospinal fluid TNF-alpha and TGF-beta2 levels in early relapsing–remitting multiple sclerosis	4
Regarding the significance of anti-COVID-IgA antibody response in COVID-19 breakthrough infection	4
Harmonization of ANA testing challenge: quantification strategy to accurately predict end-point titers avoiding serial dilution	4
Role of IL-22 in intestinal microenvironment and potential targeted therapy through diet	4
Monogenic inborn errors of immunity in autoimmune disorders	4
Serum decoy receptor 3 (DcR3): a promising biomarker for atopic asthma in children	4
APLAID complicated with arrhythmogenic dilated cardiomyopathy caused by a novel PLCG2 variant	4
SAPHO syndrome after COVID-19 vaccination complicated with thyroid function abnormalities: a case report and literature review	4
Anti-inflammatory effects of 1,7-dihydroxy-3,4-dimethoxyxanthone through inhibition of M1-phenotype macrophages via arginine/mitochondrial axis	4
Hidradenitis suppurativa and rheumatoid arthritis: evaluating the bidirectional association	4
Highlighting the role of CD44 in cervical cancer progression: immunotherapy’s potential in inhibiting metastasis and chemoresistance	4
OGT promotes the ferroptosis of chondrocytes in osteoarthritis development via O-GlcNAcylation modification of ACSF2	4
Sustainability, intelligence, and more immunology: time to get back to the future!	4
tRNA-derived fragments: biomarkers and therapeutic targets in autoimmune diseases	4
ASIA syndrome after BNT162b2 vaccination: Is it a distinct rheumatoid arthritis phenotype?	4
Analysis of binding and authentic virus-neutralizing activities of immune sera induced by various monkeypox virus antigens	4
A novel ITGB2 variant with long survival in patients with leukocyte adhesion defect type-I	4
Altered CD27-related T cell subsets reflect immune imbalance in systemic lupus erythematosus	4
SPDYC serves as a prognostic biomarker related to lipid metabolism and the immune microenvironment in breast cancer	4
Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study	4
Clinical features and potential markers of disease in idiopathic non-histaminergic angioedema, a real-life study	4
Research progress on drugs targeting the TGF-β signaling pathway in fibrotic diseases	4
H19 is involved in the regulation of inflammatory responses in acute gouty arthritis by targeting miR-22-3p	4
Neurological symptoms and axonal damage in COVID-19 survivors: are there sequelae?	4
Rational design of multi-epitope-based vaccine by exploring all dengue virus serotypes proteome: an immunoinformatic approach	4
Correction to: The immune regulatory function of B7-H3 in malignancy: spotlight on the IFN-STAT1 axis and regulation of tumor-associated macrophages	4