OOIR: Observatory of International Research

Papers

(The TQCC of Immunologic Research is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)

Article	Citations
The effect of mutatio-type on proteo-phenotype and clinico-phenotype in selected primary immunodeficiencies	63
Somatic hypermutation defects in two adult hyper immunoglobulin M patients	60
B cell repertoire in patients with a novel BTK mutation: expanding the spectrum of atypical X-linked agammaglobulinemia	60
MiR-29a-3p negatively regulates circulating Tfh memory cells in patients with Graves’ disease by targeting ICOS	58
Quantitative evaluation of citrullinated fibrinogen for detection of neutrophil extracellular traps	53
Genetic variability of three common NK and γδ T cell receptor genes (FCγ3R, NCR3, and DNAM-1) and their role in Polish patients with rheumatoid arthritis and ankylosing spondylitis	41
Belimumab 10 years later: how drug positioning has changed	40
A case of atypical infantile de novo antiphospholipid syndrome presenting with neonatal ischemic stroke without any triggering risk factors as a “second hit” and review of the literature	38
Rapid generation of an RBL cellular model to study proteins that cause allergenic reactions in vitro	35
Role of booster with BNT162b2 mRNA in SARS-CoV-2 vaccination in patients with rheumatoid arthritis	34
Laboratory and clinical practices in antinuclear antibody detection and related antigens: recommendations from a Spanish multicentre survey	34
Hypoxia modulates human mast cell adhesion to hyaluronic acid	28
Macrophage subsets and their role: co-relation with colony-stimulating factor-1 receptor and clinical relevance	26
The cGAS-STING axis: a comprehensive review from immune defense to disease pathogenesis	25
Activation of autophagy reverses gemcitabine-induced immune inhibition of RAW264.7 macrophages by promoting TNF-α, IL-6 and MHC-II expression	25
[Cuproptosis-related immune gene signature predicts clinical benefits from anti-PD-1/PD-L1 therapy in non-small-cell lung cancer	25
ANCA detection with solid phase chemiluminescence assay: diagnostic and severity association in vasculitis	23
A ubiquitin–proteasome system-related signature to predict prognosis, immune infiltration, and therapy efficacy for breast cancer	23
Lipocalin 2—not only a biomarker: a study of current literature and systematic findings of ongoing clinical trials	21
Clinical relevance and frequency of cytoplasmic patterns observed in ANA-Hep-2: experience of Cairo University Hospitals	21
CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis	21
Immunomodulatory activities of carbon quantum dots on the primary macrophages and whole splenocytes	19
Manipulation of the tumor immuno-microenvironment via TAM-targeted expression of transcription factors	19
Immune tumoral microenvironment in gliomas: focus on CD3+ T cells, Vδ1+ T cells, and microglia/macrophages	18
Correction: Major histocompatibility complex class I molecule expression by pancreatic cancer cells is regulated by activation and inhibition of the epidermal growth factor receptor	17

A patient with RFX5 variant causing an expression defect in both HLA ABC and HLA DR	16
Tryptanthrin attenuates TLR3-mediated STAT1 activation in THP-1 cells	16
T cell receptor clonotype in tumor microenvironment contributes to intratumoral signaling network in patients with colorectal cancer	16
B-cell activating factor BAFF as a novel alert marker for the immunological risk stratification after kidney transplantation	16
Potential therapeutic strategies for myocardial infarction: the role of Toll-like receptors	16
Bergamottin protects against LPS-induced endotoxic shock by regulating the NF-κB signaling pathway	16
Juvenile dermatomyositis associated with autoantibodies to small ubiquitin-like modifier activating enzyme: a report of 4 cases from North India and a review of literature	15
The Janus kinase inhibitor (baricitinib) suppresses the rheumatoid arthritis active marker gliostatin/thymidine phosphorylase in human fibroblast-like synoviocytes	15
The expression of CD86 in CD3+CD56+ NKT cells is associated with the occurrence and prognosis of sepsis-associated encephalopathy in sepsis patients: a prospective observational cohort study	14
Association of IL-23R and IL-10 variations with Behçet disease: a genetic analysis study	14
Semaphorin 3 a restores the ability of type 1 regulatory T cells to suppress food allergy	14
Pan-genome and reverse vaccinology approaches to design multi-epitope vaccine against Epstein-Barr virus associated with colorectal cancer	13
Clinical and molecular profile of 20 patients with DOCK8 deficiency—a single-center experience from Southern India	13
Melatonin: a potential therapeutic approach for the management of primary Sjögren’s syndrome	12
Dominance and improved survivability of human γδT17 cell subset aggravates the immunopathogenesis of pemphigus vulgaris	12
Efficacy and safety of IL-23 inhibitors in the treatment of psoriatic arthritis: a meta-analysis based on randomized controlled trials	12
Thyroid receptor β might be responsible for breast cancer associated with Hashimoto’s thyroiditis: a new insight into pathogenesis	11
Impaired inducibility of immune regulatory capacity of peripheral B cells of patients with recurrent pregnancy loss	11
Case report: Synergistic defects of CASP10 and BTK leading to autoimmune lymphoproliferative syndrome type IIa, complicated by severe hemophagocytic lymphohistiocytosis	11
Expression of O-glycosylated oncofetal fibronectin in alternatively activated human macrophages	11
The urease E subunit vaccine stimulate the immune response versus Helicobacter pylori in animal model	11
Post-translational modification in the pathogenesis of vitiligo	11
miR-141-3p attenuates inflammation and oxidative stress–induced pulmonary fibrosis in ARDS via the Keap1/Nrf2/ARE signaling pathway	11
Immunomodulatory effects of alexidine dihydrochloride on mammalian macrophages through the modulation of the JNK pathway	10
Translational and structural vaccinomics approach to design a multi-epitope vaccine against NOL4 autologous antigen of small cell lung cancer	10
Extracellular vesicle–encapsulated miR-10a-5p derived from MDSCs restrains germinal center B cells in experimental Sjögren’s syndrome	10
Comparison of artificial intelligence applications and commercial system performances using selected ANA IIF images	10
Amphibian cellular immune response to chytridiomycosis at metamorphic climax	10
High mobility group box 1 (HMGB1) inhibition attenuates lipopolysaccharide-induced cognitive dysfunction and sickness-like behavior in mice	10
Role of the basophil activation test in the diagnosis and management of immediate drug reaction to injectable growth hormone preparation: a case report	10
Discouraging Non-ELISA antiphospholipid antibody assays in antiphospholipid syndrome classification may hinder clinical research	9
Inhibition of cIAP1/2 reduces RIPK1 phosphorylation in pulmonary endothelial cells and alleviate sepsis-induced lung injury and inflammatory response	9
Increased synthesis and intestinal expression of IL-39 in patients with inflammatory bowel disease	9
Reactivity of DENV-positive sera against recombinant envelope proteins produced in bacteria and eukaryotic cells	9
Current genetic defects in common variable immunodeficiency patients on the geography between Europe and Asia: a single-center experience	9
Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses — a randomized, placebo-controlled clinical trial	9
mTOR-mediated differentiation and maintenance of suppressive T cells at the center stage of IPEX treatment	8
Integrative bioinformatics and experimental analyses identify U2SURP as a novel lactylation-related prognostic signature in esophageal carcinoma	8
FOXO1 contributes to cigarette smoke condensate–induced cellular senescence and fibrosis in lung fibroblasts through activating the TGF-β1/Smad2/3 signaling pathway	8
In vitro treatment of triple-negative breast cancer cells with an extract from the Coriolus versicolor mushroom changes macrophage properties related to tumourigenesis	8
Insights into inflammasome regulation: cellular, molecular, and pathogenic control of inflammasome activation	8
Coexistence of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and IgA nephropathy	8
Utility of simultaneous quantification of TREC/KREC in patients with common variable immunodeficiency phenotype: an observational study from North India	7
Predictive biomarkers of response to tocilizumab in giant cell arteritis (GCA): correlations with imaging activity	7
DMRT3-mediated lncRNA OIP5-AS1 promotes the pyroptosis of bronchial epithelial cells by binding with EIF4A3 to enhance YAP mRNA stability	7
Regnase-1 regulates inflammation in T cells of ankylosing spondylitis through the TRAF6	7
New-onset eosinophilic granulomatosis with polyangiitis in 2 patients during treatment with IL-5 pathway inhibitors	7
The effect of the BNT162b2 vaccine on antinuclear antibody and antiphospholipid antibody levels	7
Retinoic acid increases the cellular cholesterol predominantly in a mTOR-independent manner	7
Identification of nafamostat mesylate as a selective stimulator of NK cell IFN-γ production via metabolism-related compound library screening	7

Fructus lycii oligosaccharide alleviates acute liver injury via PI3K/Akt/mTOR pathway	7
Autophagic reprogramming of bone marrow–derived macrophages	7
SARS-CoV-2 antibodies in inflammatory neurological conditions: a multicentre retrospective comparative study	7
Mass cytometry revealed the circulating immune cell landscape across different Suzuki stages of Moyamoya disease	6
Conventional Tregs in treatment-naïve rheumatoid arthritis are deficient in suppressive function with an increase in percentage of CXCR3 and CCR6 expressing Tregs	6
Recurrent high fever with macular papules in an elderly male: a case report	6
Exploring CCR5 + T regulatory cell subset dysfunction in type 1 diabetes patients: implications for immune regulation	6
Investigation of T lymphocyte subsets in children with Mycoplasma pneumoniae pneumonia	6
A short focus, azithromycin in the treatment of respiratory viral infection COVID-19: efficacy or inefficacy?	6
Targeting the neonatal Fc receptor (FcRn) is not beneficial in an animal model of chronic neuritis	6
Anti-complement factor H (CFH) autoantibodies could delay pristane-induced lupus nephritis	6
Phillyrin inhibits oxidative stress and neutrophil extracellular trap formation through the KEAP1/NRF2 pathway in gouty arthritis	6
Analysis of inflammation-related microRNA expression in patients with ankylosing spondylitis	6
Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions	6
Polyethylene glycol and immunology: aspects of allergic reactions and their mechanisms, as well as ways to prevent them in clinical practice	5
An overview of the biological and multifunctional roles of IL-38 in different infectious diseases and COVID-19	5
Thymic tuft cells: potential “regulators” of non-mucosal tissue development and immune response	5
CCR2+TREM-1+ monocytes promote natural killer T cell dysfunction contributing towards HBV disease progression	5
A novel loss of function mutation in the HAVCR2 gene in a patient diagnosed with Hodgkin’s lymphoma	5
Correction to: A latent pathogen infection classification system that would significantly increase healthcare safety	5
Autoimmune lymphoproliferative syndrome (ALPS) due to a novel dominant negative germline mutation in the FAS gene	5
Circular RNA hsa_circ_0001598 promotes programmed death-ligand-1-mediated immune escape and trastuzumab resistance via sponging miR-1184 in breast cancer cells	5
Analysis of PD-1, PD-L1, and T-cell infiltration in angiosarcoma pathogenetic subgroups	5
Vitamin D receptor gene polymorphisms are associated with the risk and features of myasthenia gravis in the Han Chinese population	5
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice	5
The prognostic value of IgA anti-citrullinated protein antibodies and rheumatoid factor in an early arthritis population with a treat-to-target approach	5
An association study on the risk, glucocorticoids effectiveness, and prognosis of systemic lupus erythematosus: insight from mitochondrial DNA copy number	5
Clinical profile and management of pediatric hereditary angioedema in resource-constrained settings: our experience from a single centre in North India	5
APLAID complicated with arrhythmogenic dilated cardiomyopathy caused by a novel PLCG2 variant	4
tRNA-derived fragments: biomarkers and therapeutic targets in autoimmune diseases	4
Hidradenitis suppurativa and rheumatoid arthritis: evaluating the bidirectional association	4
Research progress on drugs targeting the TGF-β signaling pathway in fibrotic diseases	4
OGT promotes the ferroptosis of chondrocytes in osteoarthritis development via O-GlcNAcylation modification of ACSF2	4
Regarding the significance of anti-COVID-IgA antibody response in COVID-19 breakthrough infection	4
Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study	4
Neurological symptoms and axonal damage in COVID-19 survivors: are there sequelae?	4
ASIA syndrome after BNT162b2 vaccination: Is it a distinct rheumatoid arthritis phenotype?	4
Peripheral distributions of IL-4-producing CD4 + T cells and CD4 + CD25 + FoxP3 + T cells (Tregs) in rheumatoid arthritis patients with poor response to therapy are associated with HLA shared epitope	4
Versatile roles for neutrophil proteinase 3 in hematopoiesis and inflammation	4
SPDYC serves as a prognostic biomarker related to lipid metabolism and the immune microenvironment in breast cancer	4
Lower frequency of T stem cell memory (TSCM) cells in hepatitis B vaccine nonresponders	4
A latent pathogen infection classification system that would significantly increase healthcare safety	4
Clinical features and potential markers of disease in idiopathic non-histaminergic angioedema, a real-life study	4
The alterations of cerebrospinal fluid TNF-alpha and TGF-beta2 levels in early relapsing–remitting multiple sclerosis	4
Highlighting the role of CD44 in cervical cancer progression: immunotherapy’s potential in inhibiting metastasis and chemoresistance	4
The function of CD8 + T cells in the absence of MHC-I in target cells: what to learn from the deficiency of MHC-I expression in humans	4
The mechanism of p38 MAPK, NF-κB, and IL-6 in T-2 toxin and/or selenium deficiency induced spleen injury	4
Correction to: The immune regulatory function of B7-H3 in malignancy: spotlight on the IFN-STAT1 axis and regulation of tumor-associated macrophages	4
Analysis of binding and authentic virus-neutralizing activities of immune sera induced by various monkeypox virus antigens	4
Serum decoy receptor 3 (DcR3): a promising biomarker for atopic asthma in children	4
Harmonization of ANA testing challenge: quantification strategy to accurately predict end-point titers avoiding serial dilution	4
Altered CD27-related T cell subsets reflect immune imbalance in systemic lupus erythematosus	4
Insights into the immunological description of cryoglobulins with regard to detection and characterization in Slovenian rheumatological patients	4
Involvement of gut microbiota in multiple sclerosis—review of a new pathophysiological hypothesis and potential treatment target	4
Sustainability, intelligence, and more immunology: time to get back to the future!	4
Monophosphoryl lipid A as a co-adjuvant in methicillin-resistant Staphylococcus aureus vaccine development: improvement of immune responses in a mouse model of infection	4
H19 is involved in the regulation of inflammatory responses in acute gouty arthritis by targeting miR-22-3p	4
HLA-E-expressing macrophage polarization and increased NKG2A/CD94 expression in adult-onset Still’s disease	4
Anti-inflammatory effects of 1,7-dihydroxy-3,4-dimethoxyxanthone through inhibition of M1-phenotype macrophages via arginine/mitochondrial axis	4
Monogenic inborn errors of immunity in autoimmune disorders	4
SAPHO syndrome after COVID-19 vaccination complicated with thyroid function abnormalities: a case report and literature review	4
A novel ITGB2 variant with long survival in patients with leukocyte adhesion defect type-I	4