Journal of Applied Toxicology

Article	Citations
Cadmium as a testicular toxicant: A Review	68
Zebrafish: An emerging model system to study liver diseases and related drug discovery	54
A review on nanotoxicity and nanogenotoxicity of different shapes of nanomaterials	48
Comparison of toxicity of Ti3C2 and Nb2C Mxene quantum dots (QDs) to human umbilical vein endothelial cells	46
Neurotoxicity of metal‐containing nanoparticles and implications in glial cells	42
The toxicity of ambient fine particulate matter (PM2.5) to vascular endothelial cells	41
Environmental distribution, transport and ecotoxicity of microplastics: A review	40
Copper induces oxidative stress and apoptosis of hippocampal neuron via pCREB/BDNF/ and Nrf2/HO‐1/NQO1 pathway	38
Research advance on cell imaging and cytotoxicity of different types of quantum Dots	37
In vitro anticancer activity of fluphenazine, perphenazine and prochlorperazine. A review	33
Research progress on toxicity, function, and mechanism of metal oxide nanoparticles on vascular endothelial cells	31
Toxicological safety evaluation of pasteurized Akkermansia muciniphila	29
α‐Asarone, β‐asarone, and γ‐asarone: Current status of toxicological evaluation	29
A review of transgenerational and multigenerational toxicology in the in vivo model animal Caenorhabditis elegans	28
Toxic compounds produced by cyanobacteria belonging to several species of the order Nostocales: A review	27
Environmental exposure of the general population to cadmium as a risk factor of the damage to the nervous system: A critical review of current data	26
The impact of environmental and occupational exposures of manganese on pulmonary, hepatic, and renal functions	24
Organoids: A new approach in toxicity testing of nanotherapeutics	23
Collecting e‐cigarette aerosols for in vitro applications: A survey of the biomedical literature and opportunities to increase the value of submerged cell culture‐based assessments	23
Behavioural effects of early‐life exposure to parabens in zebrafish larvae	23
In silico prediction of mitochondrial toxicity of chemicals using machine learning methods	23
A new look at 9‐substituted acridines with various biological activities	22
Fumonisin B1‐induced mitochondrial toxicity and hepatoprotective potential of rooibos: An update	21
Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells	21
Potential roles of Kruppel‐like factors in mediating adverse vascular effects of nanomaterials: A review	21

Toxicity of orally administered food‐grade titanium dioxide nanoparticles	20
Aluminium in cosmetics and personal care products	20
Mechanisms and biological impacts of graphene and multi‐walled carbon nanotubes on Drosophila melanogaster: Oxidative stress, genotoxic damage, phenotypic variations, locomotor behav	19
Chronic exposure to di‐n‐butyl phthalate causes reproductive toxicity in zebrafish	19
Toxic implications of silver nanoparticles on the central nervous system: A systematic literature review	18
Comparative evaluation on the toxic effect of silver (Ag) and zinc oxide (ZnO) nanoparticles on different trophic levels in aquatic ecosystems: A review	18
PFOS facilitates liver inflammation and steatosis: An involvement of NLRP3 inflammasome‐mediated hepatocyte pyroptosis	18
Toxicity of quantum dots on target organs and immune system	17
Near‐infrared emission Cu, N‐doped carbon dots for human umbilical vein endothelial cell labeling and their biocompatibility in vitro	16
Developmental neurotoxicity and toxic mechanisms induced by olaquindox in zebrafish	16
Cantharidin‐induced acute hepatotoxicity: the role of TNF‐α, IKK‐α, Bcl‐2, Bax and caspase3	15
Recent advances in polyphenols improving vascular endothelial dysfunction induced by endogenous toxicity	15
Aconitine disrupts serotonin neurotransmission via 5‐hydroxytryptamine receptor in zebrafish embryo	15
Activation of aryl hydrocarbon receptor by benzo[a]pyrene increases interleukin 33 expression and eosinophil infiltration in a mouse model of allergic airway inflammation	15
A comparative study of toxicity of graphdiyne and graphene oxide to human umbilical vein endothelial cells	15
Cellular effects of nicotine salt‐containing e‐liquids	15
Demonstration of the first‐pass metabolism in the skin of the hair dye, 4‐amino‐2‐hydroxytoluene, using the Chip2 skin–liver microphysiological model	15
Summary of 17 chemicals evaluated by OECD TG229 using Japanese Medaka,Oryzias latipesin EXTEND 2016	14
Therapeutic nanostructures and nanotoxicity	14
Toxicity of transition metal nanoparticles: A review of different experimental models in the gastrointestinal tract	14
Role of the Hippo‐YAP/NF‐κB signaling pathway crosstalk in regulating biological behaviors of macrophages under titanium ion exposure	14
Effect of thyroid hormone‐disrupting chemicals on swim bladder inflation and thyroid hormone‐related gene expression in Japanese medaka and zebrafish	14
Emerging mycotoxins and reproductive effects in animals: A short review	14
Cantharidin‐induced LO2 cell autophagy and apoptosis via endoplasmic reticulum stress pathway in vitro	14
Ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane: Toxicological effects on marine biota and human concerns	13
Seneciphylline, a main pyrrolizidine alkaloid in Gynura japonica, induces hepatotoxicity in mice and primary hepatocytes via activating mitochondria‐mediated apoptosis	13
Anthraquinones inhibit cytochromes P450 enzyme activity in silico and in vitro	13
Linking emerging contaminants exposure to adverse health effects: Crosstalk between epigenome and environment	13
Comprehensive pulmonary toxicity assessment of cetylpyridinium chloride using A549 cells and Sprague–Dawley rats	13
Accumulation of molybdenum in major organs following repeated oral administration of bis‐choline tetrathiomolybdate in the Sprague Dawley rat	13
Asthma‐inducing potential of 28 substances in spray cleaning products—Assessed by quantitative structure activity relationship (QSAR) testing and literature review	13
Estrogen receptor α activation aggravates imiquimod‐induced psoriasis‐like dermatitis in mice by enhancing dendritic cell interleukin‐23 secretion	13
Cadmium exposure induces endothelial dysfunction via disturbing lipid metabolism in human microvascular endothelial cells	13
Impact of airborne total suspended particles (TSP) and fine particulate matter (PM2.5)‐induced developmental toxicity in zebrafish (Danio rerio) embryos	12
Toxicity evaluation of mesoporous silica particles Santa Barbara No. 15 amorphous in human umbilical vein endothelial cells: influence of particle morphology	12
Oxidative stress‐mediated apoptosis is involved in bisphenol S‐induced reproductive toxicity in male C57BL/6 mice	12
A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos	12
A pioneer study on human 3‐nitropropionic acid intoxication: Contributions from metabolomics	12
Exposure to 4‐nonylphenol induces a shift in the gene expression of gsdf and testis‐ova formation and sex reversal in Japanese medaka (Oryzias latipes)	12
Toxicological alterations induced by subacute exposure of silver nanoparticles in Wistar rats	12
Summary of reference chemicals evaluated by the fish short‐term reproduction assay, OECD TG229, using Japanese Medaka, Oryzias latipes	12
Efficacy of water skin decontamination in vivo in humans: A systematic review	12
Research progress on the carcinogenicity of metal nanomaterials	12
Brain delivery of antidotes by polymeric nanoparticles	12
Theoretical study on endocrine disrupting effects of polychlorinated dibenzo‐p‐dioxins using molecular docking simulation	11
Heavy metals exposure is associated with early liver dysfunction among rural residents aged 40–75 years in southwest China	11
Integrated approaches to testing and assessment as a tool for the hazard assessment and risk characterization of cosmetic preservatives	11
The human health risks assessment of mercury in soils and plantains from farms in selected artisanal and small‐scale gold mining communities around Obuasi, Ghana	11
Design cytotoxicity: The effect of silver nanoparticles stabilized by selected antioxidants on melanoma cells	11
Environmental cadmium exposure and noncancer mortality in a general Japanese population in cadmium nonpolluted regions	11

Progress in research on effect of PM2.5 on occurrence and development of atherosclerosis	11
Acute high‐dose titanium dioxide nanoparticle exposure alters gastrointestinal homeostasis in mice	11
Drosophila melanogaster as a dynamic in vivo model organism reveals the hidden effects of interactions between microplastic/nanoplastic and heavy metals	11
Acute and subacute toxicity evaluation of Houttuynia cordata ethanol extract and plasma metabolic profiling analysis in both male and female rats	11
Methyl farnesoate regulatory mechanisms underlying photoperiod‐dependent sex determination in the freshwater crustacean Daphnia magna	11
Characterization of microparticles derived from waste plastics and their bio‐interaction with human lung A549 cells	11
Maternal organophosphate flame‐retardant exposure alters offspring feeding, locomotor and exploratory behaviors in a sexually‐dimorphic manner in mice	11
Neurobehavior and neuron damage following prolonged exposure of silver nanoparticles with/without polyvinylpyrrolidone coating in Caenorhabditis elegans	11
Long‐term exposure to triclosan increases migration and invasion of human breast epithelial cells in vitro	11
Changes of embryonic development, locomotor activity, and metabolomics in zebrafish co‐exposed to chlorpyrifos and deltamethrin	10
Specific expression of survivin, SOX9, and CD44 in renal tubules in adaptive and maladaptive repair processes after acute kidney injury in rats	10
Changes of lipid profiles in human umbilical vein endothelial cells exposed to zirconia nanoparticles with or without the presence of free fatty acids	10
A systematic review of microRNA expression studies with exposure to bisphenol A	10
Progress on the toxicity of quantum dots to model organism‐zebrafish	10
Carbofuran cytotoxicity, DNA damage, oxidative stress, and cell death in human umbilical vein endothelial cells: Evidence of vascular toxicity	10
Exposure to mono (2‐ethylhexyl) phthalate facilitates apoptosis and pyroptosis of human endometrial microvascular endothelial cells through NLRP3 inflammasome	10
Use of a common European approach for nanomaterials’ testing to support regulation: a case study on titanium and silicon dioxide representative nanomaterials	10
Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE−/− mouse mod	10
A pH‐responsive polymer linked with immunomodulatory drugs: synthesis, characteristics and in vitro biocompatibility	10
Acridine derivatives as inhibitors/poisons of topoisomerase II	9
Activation of forkhead box O3a by mono(2‐ethylhexyl)phthalate and its role in protection against mono(2‐ethylhexyl)phthalate‐induced oxidative stress and apoptosis in human cardiomyocytes	9
Acute and subacute inhalation toxicity assessment of WS‐23 in Sprague–Dawley rats	9
The impact of oral exposure to low‐dose tris(2‐butoxyethyl) phosphate in allergic asthmatic mice	9
Curcumin attenuates isoniazid‐induced hepatotoxicity by upregulating the SIRT1/PGC‐1α/NRF1 pathway	9
Effect of evernic acid on human breast cancer MCF‐7 and MDA‐MB‐453 cell lines via thioredoxin reductase 1: A molecular approach	9
Comparative proteomic analysis reveals cytotoxicity induced by graphene oxide exposure in A549 cells	9
Evaluation of fentanyl toxicity and metabolism using a zebrafish model	9
Antioxidant‐modulated cytotoxicity of silver nanoparticles	9
Interactive effects of high temperature and pesticide exposure on oxidative status, apoptosis, and renin expression in kidney of goldfish: Molecular and cellular mechanisms of widespread kidney damage	9
Cell membrane‐related toxic responses and disruption of intercellular communication in PCB mechanisms of toxicity: A review	9
Cadmium inhibits neural stem/progenitor cells proliferation via MitoROS‐dependent AKT/GSK‐3β/β‐catenin signaling pathway	9
Maternal organophosphate flame‐retardant exposure alters offspring energy and glucose homeostasis in a sexually dimorphic manner in mice	8
Histone demethylase JHDM2A regulates H3K9 dimethylation in response to arsenic‐induced DNA damage and repair in normal human liver cells	8
Reactive oxygen species‐mediated activation of NLRP3 inflammasome associated with pyroptosis in Het‐1A cells induced by the co‐exposure of nitrosamines	8
In silico prediction of potential drug‐induced nephrotoxicity with machine learning methods	8
The use of in vitro methods in assessing human health risks associated with short‐chain perfluoroalkyl and polyfluoroalkyl substances (PFAS)	8
Improving predictive capacity of the Amino acid Derivative Reactivity Assay test method for skin sensitization potential with an optimal molar concentration of test chemical solution	8
Realgar‐induced nephrotoxicity via ferroptosis in mice	8
Inhibition of hypoxia‐induced HIF‐1α‐mediated autophagy enhances the in vitro antitumor activity of rhein in pancreatic cancer cells	8
Proteomic analysis of zearalenone toxicity on mouse thymic epithelial cells	8
Internalization and cytotoxicity of polystyrene microplastics in human umbilical vein endothelial cells	8
Caffeine‐induced neurotoxicity mediated by Nrf2 pathway in PC12 cells and zebrafish larvae	8
Combined effect of titanium dioxide nanoparticles and glucose on the blood glucose homeostasis in young rats after oral administration	8
Downregulation of glucose‐6‐phosphatase expression contributes to fluoxetine‐induced hepatic steatosis	8
Influence of systemic copper toxicity on early development and metamorphosis in Xenopus laevis	8
Follicular pathway role in chemical warfare simulants percutaneous penetration	8
Metabolomics approach to study in vivo toxicity of graphene oxide nanosheets	8
Assessment of zebrafish embryo photomotor response sensitivity and phase‐specific patterns following acute‐ and long‐duration exposure to neurotoxic chemicals and chemical weapon precursors	8
Lithium toxicity and the kidney with special focus on nephrotic syndrome associated with the acute kidney injury: A case‐based systematic analysis	8
Development of a novel flow cytometry‐based approach for reticulocytes micronucleus test in rat peripheral blood	8
Protocatechuic acid ameliorates lipopolysaccharide‐induced kidney damage in mice via downregulation of TLR‐4‐mediated IKBKB/NF‐κB and MAPK/Erk signaling pathways	8
Exosomal secretion may be a self‐protective mechanism of its source cells under environmental stress: A study on human bronchial epithelial cells treated with hydroquinone	7
The toxicity of cell therapy: Mechanism, manifestations, and challenges	7
In vitro copper oxide nanoparticle toxicity on intestinal barrier	7
Effects of sunset yellow on proliferation and differentiation of intestinal epithelial cells in murine intestinal organoids	7
The expression profile and bioinformatics analysis of microRNAs in human bronchial epithelial cells treated by beryllium sulfate	7
Genotoxicity and neonatal subchronic toxicity assessment of a novel mixture of the human‐identical milk oligosaccharides lacto‐N‐fucopentaose I and 2′‐fucosyllactose	7
Cyanidin‐3‐glucoside protects against high glucose‐induced injury in human nucleus pulposus cells by regulating the Nrf2/HO‐1 signaling	7
Integrating analysis of circular RNA and mRNA expression profiles in doxorubicin induced cardiotoxicity mice	7
Long‐term arsenic exposure impairs differentiation in mouse embryonal stem cells	7
Cytotoxicity of zinc oxide nanoparticles to innate and adaptive human immune cells	7
On‐going consequences of in utero exposure of Pb: An epigenetic perspective	7
Effects of methylparaben on in vitro maturation of porcine oocytes	7
Study on the mechanism of cantharidin‐induced hepatotoxicity in rat using serum and liver metabolomics combined with conventional pathology methods	7
Atorvastatin and pravastatin stimulate nitric oxide and reactive oxygen species generation, affect mitochondrial network architecture and elevate nicotinamide N‐methyltransferase level in endothelial	7
The effect of combined exposure of zinc and nickel on the development of zebrafish	7
Comparison of P25 and nanobelts on Kruppel‐like factor‐mediated nitric oxide pathways in human umbilical vein endothelial cells	7
Structural and biochemical modifications of model and native membranes of human immune cells in response to the action of zinc oxide nanoparticles	7
Neurodevelopmental toxicity induced by airborne particulate matter	7
Effects of intrauterine exposure to 2,3′,4,4′,5‐pentachlorobiphenyl on the reproductive system and sperm epigenetic imprinting of male offspring	7
Toxicological safety evaluation of live Anaerobutyricum soehngenii strain CH106	7
2D‐Quantitative structure–activity relationship modeling for risk assessment of pharmacotherapy applied during pregnancy	7
Organophosphorus flame‐retardant tris(1‐chloro‐2‐propyl)phosphate is genotoxic and apoptotic inducer in human umbilical vein endothelial cells	7
The neuroprotective effects of alpha‐lipoic acid on an experimental model of Alzheimer's disease in PC12 cells	7
Aberrant expression of miRNA‐192‐5p contributes to N,N‐dimethylformamide‐induced hepatic apoptosis	7
Efficacy of water‐only or soap and water skin decontamination of chemical warfare agents or simulants using in vitro human models: A systematic review	7
Intratracheal instillation of graphene oxide decreases anti‐virus responses and lipid contents via suppressing Toll‐like receptor 3 in mouse livers	7
Structural binding perspectives of common plasticizers and a flame retardant, BDE‐153, against thyroxine‐binding globulin: potential for endocrine disruption	7
NADPH oxidases regulate endothelial inflammatory injury induced by PM2.5 via AKT/eNOS/NO axis	6
Effects of plasticizer diisobutyl adipate on the Japanese medaka (Oryzias latipes) endocrine system	6

Effects of the mycotoxin metabolite de‐epoxy‐deoxynivalenol (DOM‐1) on embryo development and sperm motility in cattle	6
Combating silver nanoparticle‐mediated toxicity in Drosophila melanogaster with curcumin	6
Sinensetin attenuates oxygen–glucose deprivation/reperfusion‐induced neurotoxicity by MAPK pathway in human cerebral microvascular endothelial cells	6
Advances in endocrine toxicity of nanomaterials and mechanism in hormone secretion disorders	6
Gold nanoparticles regulate the antitumor secretome and have potent cytotoxic effects against prostate cancer cells	6
α‐Mangostin protects lipopolysaccharide‐stimulated nucleus pulposus cells against NLRP3 inflammasome‐mediated apoptosis via the NF‐κB pathway	6
Cytotoxicity and inflammatory effects in human bronchial epithelial cells induced by polycyclic aromatic hydrocarbons mixture	6
Molecular docking and dynamics simulation to screen interactive potency and stability of fungicide tebuconazole with thyroid and sex hormone‐binding globulin: Implications of endocrine and reproductiv	6
Indium oxide nanoparticles induce lung intercellular toxicity between bronchial epithelial cells and macrophages	6
Evaluation of the effects of herpes simplex glycoprotein B on complement system and cytokines in in vitro models of Alzheimer's disease	6
Chronic toxicity of 50 metals to Ceriodaphnia dubia	6
Toxic effects of nanomaterials for health applications: How automation can support a systematic review of the literature?	6
Farnesoid X receptor contributes to oleanolic acid‐induced cholestatic liver injury in mice	6
L‐carnitine reverses methotrexate‐induced nephrotoxicity in experimental rat model: Insight on SIRT1/PGC‐1α/Nrf2/HO‐1 axis	6
Research progress on the cellular toxicity caused by microplastics and nanoplastics	6
Induction of autophagy and endoplasmic reticulum autophagy caused by cadmium telluride quantum dots are protective mechanisms of yeast cell	6
Selenium ameliorates aflatoxin B1‐induced uterine injury in female mice and necrosis of human endometrial microvascular endothelial cells	6
Maduramicin induces cardiotoxicity via Rac1 signaling‐independent methuosis in H9c2 cells	6
Fraxetin suppresses reactive oxygen species‐dependent autophagy by the PI3K/Akt pathway to inhibit isoflurane‐induced neurotoxicity in hippocampal neuronal cells	6
Potential issues specific to cytotoxicity tests of cellulose nanofibrils	6
Comparing the effects of an exposure to a polycyclic aromatic hydrocarbon mixture versus individual polycyclic aromatic hydrocarbons during monocyte to macrophage differentiation: Mixture exposure res	6
Effects of polycaprolactone degradation products on the water flea, Daphnia magna: Carbodiimide additives have acute and chronic toxicity	6
Impact of solid lipid nanoparticles on 3T3 fibroblasts viability and lipid profile: The effect of curcumin and resveratrol loading	6
Using benchmark dose modeling for the quantitative risk assessment: Carbon nanotubes, asbestos, glyphosate	6
Doxorubicin‐induced delayed‐onset subclinical cardiotoxicity in mice	6
Gene expression network related to DNA methylation and miRNA regulation during the process of aflatoxin B1‐induced malignant transformation of L02 cells	6
General toxicity and genotoxicity of altertoxin I: A novel 28‐day multiendpoint assessment in male Sprague–Dawley rats	6
Exposure interval to ambient fine particulate matter (PM2.5) collected in Southwest China induced pulmonary damage through the Janus tyrosine protein kinase‐2/signal transducer and activator of transc	6
In vitro and in silico genetic toxicity screening of flavor compounds and other ingredients in tobacco products with emphasis on ENDS	6
Acute exposure to abuse‐like concentrations of toluene induces inflammation in mouse lungs and brain	6