Atla-Alternatives to Laboratory Animals

Article	Citations
Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model	64
Spotlight on Three Rs Progress	34
Spotlight on Three Rs Progress	31
The Safety Assessment of Cosmetic Perfumes by Using In Chemico and In Vitro Methods in Combination with GC-MS/MS Analysis	27
The Use of Human Tissues for Research: What Investigators Need to Know	27
Conference Diary	24
Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against Mycobacterium tuberculosis	23
The Development of an Animal Product-free, Precision-cut Lung Slice Cryopreservation and Post-thaw Culture Method	21
Progress and Remaining Opportunities to Increase the Use of Animal-free Antibodies in the USA	15
In Silico Prediction of Human Clinical Pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an Established Benchmarking Data Set, a Modern Small Drug Data Set, and a Comparison with La	13
A History of the Development of Alternatives to Animals in Research and Testing	11
The Rise of Three Rs Centres and Platforms in Europe*	11
Brazilian National Network of Alternative Methods (RENAMA) 10th Anniversary: Meeting of the Associated Laboratories, May 2022	10
Conference Diary	10
Editorial	9
Development of Sensitive In Vitro Protocols for the Biocompatibility Testing of Medical Devices and Pharmaceuticals Intended for Contact with the Eyes: Acute Irritation and Phototoxicity Assess	9
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders	9
Spotlight on Three Rs Progress	8
Resources Round-up	8
Editorial	7
Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway	7
2021 Michael Balls Award	7
Editorial	7
The 19th FRAME Annual Lecture, November 2022: Safer Chemicals and Sustainable Innovation Will Be Achieved by Regulatory Use of Modern Safety Science, Not by More Animal Testing	7
Reviewing Current Guidance for the ‘R’ of Replacement and Rethinking it with the ‘Replacement Checklist’	6

Editorial	6
Addressing Animal Welfare Issues in Fetal Blood Collection for Fetal Bovine Serum Production	6
A Cytotoxicity Assay as an Alternative to the Murine Model for the Potency Testing of Bothrops jararaca Venom and Antivenom: An Intralaboratory Pre-validation Study	6
Thanks to Reviewers	5
The Numbers of Animals Used in Mexico for Scientific and Educational Purposes	5
Development of Two Korean IACUC Guidance Documents to Foster Implementation of the Three Rs	5
Editorial	5
Editorial	4
JRC Summer School 2021	4
Resources Round-up	4
Optimisation of a Method for the Differentiation of Human Umbilical Cord-derived Mesenchymal Stem Cells Toward Renal Epithelial-like Cells	4
Corrigendum to Case Studies Exemplifying the Transition to Animal Component-Free Cell Culture	4
Editorial	4
The Current Status and Work of Three Rs Centres and Platforms in Europe*	3
Accelerating Animal Replacement: How Universities Can Lead — Results of a One-Day Expert Workshop in Zurich, Switzerland	3
Editorial	3
Introducing the COST Action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE)	3
The Use of 3-D Models of Echocardiographic Imaging Planes for Teaching Echocardiography Techniques for Use in Dogs and Cats	3
Editorial	3
Lessons for the Future of NAMs from History, Philosophy and Social Studies of Science	3
Case Studies Exemplifying the Transition to Animal Component-free Cell Culture	3
Spotlight on Three Rs Progress	3
Conference Diary	3
The Development and Evaluation of Brain and Heart Cell Lines from a Marine Fish for Use in Xenobiotic-Induced Cytotoxicity Testing	3
A New ATLA Associate Editor	3
Editorial	3
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Second International Conference on 3Rs Research and Progress, Hyderabad, 2021	3
Resources Round-up	2
Journeying Through Journals: The Publishing Process and How to Maximise Research Impact	2
Conference Diary	2
Use of the Allium cepa Model to Assess the Cytogenotoxicity of Luffariella herdmani Marine Sponge Extract	2
Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids	2
Transparency in Non-Technical Project Summaries to Promote the Three Rs in Respiratory Disease Research	2
The Evolution of Regulatory Toxicology: Where is the Gardener?	2
Editorial	2
Spotlight on Three Rs Progress	2
An Evaluation of the Replacement of Animal-derived Biomaterials in Human Primary Cell Culture	2
The Use of Artificial Intelligence for the Fast and Effective Identification of Three Rs-based Literature	2
ATLA Best Poster Award	2
The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside	2
Editorial	1
Conference Diary	1
Resources Round-up	1
Poster Prizes 2021	1
Spotlight on Three Rs Progress	1
Conference Diary	1
Editorial	1
A Comparison of Mesenchymal Stem Cell-derived Hepatocyte-like Cells and HepG2 Cells for Use in Drug-Induced Liver Injury Studies	1
JRC Summer School on Non-animal Approaches in Science, May 2021	1
Conference Diary	1

Academic Training to Promote the Implementation of Alternative Methods and the Three Rs in the Field of Toxicology	1
Spotlight on Three Rs Progress	1
Editorial	1
Resources Round-up	1
Resources Round-up	1
Resources Round-up	1
The Use of Simulators for Teaching Practical Clinical Skills to Veterinary Students — A Review	1
The Effects of Urolithin B and Auraptene on Quinolinic Acid-induced Toxicity in the SH-SY5Y Neuroblastoma Cell Line	1
Corrigendum to Report of the First ONTOX Hackathon: Hack to Save Lives and Avoid Animal Suffering. The Use of Artificial Intelligence in Toxicology — A Potential Driver for Reducing/Replacing Laborato	1
Spotlight on Three Rs Progress	1
An Accessible Nephrectomy and Cystotomy Simulator for Use in Teaching Small Animal Surgery	1
Resources Round-up	1
The VEGAHUB Platform: The Philosophy and the Tools	1
Assessment of a Low-cost Canine Uterine Simulator as a Tool for Teaching the Ovariohysterectomy Technique to Veterinary Students	1
Biobank Personnel — The Key to its Success	1
Alternatives to Laboratory Animals: Trends in Replacement and the Three Rs	1
Spotlight on Three Rs Progress	1
Barriers to the Use of Recombinant Bacterial Endotoxins Test Methods in Parenteral Drug, Vaccine and Device Safety Testing	1
Resources Round-up	1
Comparison of Long-term Human Precision-cut Lung Slice Culture Methodology and Response to Challenge: An Argument for Standardisation	1
Educators’ Views on the Use of Dissection and Dissection Alternatives in American Biology Classrooms	0
Recent ATLA Awards	0
Editorial	0
Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance	0
Rethinking the Three Rs: Growing Momentum Toward a New Gold Standard in Australian Research	0
Resources Round-up	0
2023 Michael Balls Award	0
Dr Richard Clothier: FRAME Trustee, Founding Director of the FRAME Laboratory and ATLA Editorial Board Member	0
Spotlight on Three Rs Progress	0
Editorial	0
In Vitro Dengue Virus Inhibition by Aqueous Extracts of Aegle marmelos, Munronia pinnata and Psidium guajava	0
A History of the Development of Alternatives to Animals in Research and Testing	0
Thanks to Reviewers	0
Evaluation of a Low-cost Renal Simulator for the Diagnostic Ultrasound Training of Veterinary Medicine Students	0
Resources Round-up	0
Coculture of ARPE-19 Cells and Porcine Neural Retina as an Ex Vivo Retinal Model	0
Spotlight on Three Rs Progress	0
Message from FRAME	0
Permutation Tests Are a Useful Alternative Approach for Statistical Hypothesis Testing in Small Sample Sizes	0
Ex Vivo Human Skin: An Alternative Test System for Skin Irritation and Corrosion Assays	0
Spotlight on Three Rs Progress	0
Towards More Human and Humane Testing: The Role of the Device Supplier Industry	0
It’s Time to Review the Three Rs, to Make them More Fit for Purpose in the 21st Century	0
A Systematic Review of Published Physiologically-based Kinetic Models and an Assessment of their Chemical Space Coverage	0
The Use of an In Chemico Digestibility Assay to Reduce the In Vivo Fish Bioaccumulation Testing of Nanomaterials	0
Editorial	0
Conference Diary	0
Chitosan–Calcium Aluminate as a Cell-homing Scaffold: Its Bioactivity Testing in a Microphysiological Dental Pulp Platform	0
Calling all students and early-career researchers — Join us for the second Summer School on Innovative Approaches in Science!	0
Editorial	0
The Use of In Silico Methods to Identify and Assess Antigenic Regions Suitable for the Development of Peptide-based Pan-viral Vaccines	0
Resources Round-up	0
Editorial	0
Resources Round-up	0
Conference Diary	0
Evaluating the Impact of Hair Care Product Exposure on Hair Follicle and Scalp Health	0
EURL ECVAM Activities	0
Resources Round-up	0
Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters	0
Conference Diary	0
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022	0
Poor Translatability of Biomedical Research Using Animals — A Narrative Review	0
Conference Diary	0
Resources Round-up	0
Resources Round-up	0
Key Challenges for In Vitro Testing of Tobacco Products for Regulatory Applications: Recommendations for the In Vitro Mouse Lymphoma Assay	0
Expression of Concern: “Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway”	0
How to Foster ‘New Approach Methodology’ Toxicologists	0
Spotlight on Three Rs Progress	0
A History of Regulatory Animal Testing: What Can We Learn?	0
Resources Round-up	0
Spotlight on Three Rs Progress	0
Book Review: Zebrafish Model for Biomedical Research	0
Editorial	0
Resources Round-up	0
Determination of the Microinjected Cytosolic Concentration by Using Mathematical Models of Fluid Dynamics	0
Resources Round-up	0
Conference Diary	0
A Short History of the Consideration of Sex Differences in Biomedical Research — Lessons for the In Vitro Community from Animal Models and Human Clinical Trials	0
Cigarette Smoke Constituents and Nicotine Differentially Affect Cytokine Production by Human Macrophages Stimulated by TLR Ligands In Vitro: Considerations for a Standardised Protocol	0

Resources Round-up	0
2022 Michael Balls Award	0
Cardiac Transcription Regulators Differentiate Human Umbilical Cord Mesenchymal Stem Cells into Cardiac Cells	0
Is UK Animal Research Governance Facing a ‘New Normal’? Considering the Risks and Benefits of ‘Going Online’	0
Upholding the EU's Commitment to ‘Animal Testing as a Last Resort' Under REACH Requires a Paradigm Shift in How We Assess Chemical Safety to Close the Gap Between Regulatory Testing and Modern Safety	0
Conference Diary	0
Conference Diary	0
It’s Time to Include Harm to Humans in Harm–Benefit Analysis — But How to Do It, That is the Question	0
A Comparison of European Union and Turkish Reports on the Statistics of Experimental Animal Use in Toxicity Testing	0
The Capability Maturity Model as a Measure of Culture of Care in Laboratory Animal Science	0
Conference Diary	0
20 Years of Providing Custom Non-Animal-Derived Antibodies — A Review	0
Resources Round-up	0
In Silico Phototoxicity Prediction of Drugs and Chemicals by using Derek Nexus and QSAR Toolbox	0
Conference Diary	0
Conference Diary	0
Chemicals 2.0 and Why We Need to Bypass the Gold Standard in Regulatory Toxicology	0
Development of an Accessible Gene Expression Bioinformatics Pipeline to Study Driver Mutations of Colorectal Cancer	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Conference Diary	0
The Accomplishments of KoCVAM in the Development and Implementation of Alternative Methods in Korea	0
A Novel Ex Vivo Blinking Method for Comparing the Corneal Residence Time of New Shampoo Formulations	0
Optimisation of Conditions for the Formation of Spheroids of Head and Neck Squamous Cell Carcinoma Cell Lines for Use as Animal Alternatives	0
Spotlight on Three Rs Progress	0
Development of an In Vitro Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells	0
Biomedical Research on Substances of Abuse: The Italian Case Study	0
Acute Toxicity Assays with the Artemia salina Model: Assessment of Variables	0
Conference Diary	0
Thanks to Reviewers	0
Conference Diary	0
A Low-fidelity Simulator for the Development of Vascular Ligation Skills	0
Editorial	0
Evaluating the Protective Effects of Thymoquinone on Methamphetamine-induced Toxicity in an In Vitro Model Based on Differentiated PC12 Cells	0
Zebrafish Beyond the Bench: The ‘Plataforma Zebrafish Open Doors’ Programme	0
Implementing the EURL ECVAM Recommendation on Non-Animal-Derived Antibodies in One EU Member State — Denmark	0
Celebrating Professor Horst Spielmann’s 80th Birthday	0
A Human Cell-based Assay to Assess the Induction of Vasculature Formation for Non-genotoxic Carcinogenicity Testing Purposes: A Pilot Study	0
Spotlight on Three Rs Progress	0
An Approach to Setting Vertebrate Animal-use Benchmarks for Agrochemical and GM Crop Testing to Facilitate Future Animal Reduction Efforts	0
Spotlight on Three Rs Progress	0
Spotlight on Three Rs Progress	0
Adapting to Changes in Publishing When Searching for Alternatives and Reporting on Animal Research: A Librarian’s Perspective	0
The 3Ranker: An AI-based Algorithm for Finding Non-animal Alternative Methods	0
Conference Diary	0
Spotlight on Three Rs Progress	0
The Prevalence of Reported Gavage Incidents in Repeated Dose Toxicity Studies Involving Rats Conducted Between 2004–2023	0
Editorial	0
Resources Round-up	0
The Use of MPS in Three Rs and Regulatory Applications: Perspectives From Developers on Stakeholder Responsibilities	0
The Perceptions of Students and Lecturers on the Use of Animals in Biomedical Science Undergraduate Education in Brazil	0
Editorial	0
Spotlight on Three Rs Progress	0
An Evaluation of Different Types of Peptone as Partial Substitutes for Animal-derived Serum in Vero Cell Culture	0
Editorial	0
Conference Diary	0
Resources Round-up	0
Thanks to Reviewers	0
In Silico Prediction of Eye Irritation Using Hansen Solubility Parameters and Predicted pKa Values	0
Spotlight on Three Rs Progress	0
Spotlight on Three Rs Progress	0
Report of the First ONTOX Hackathon: Hack to Save Lives and Avoid Animal Suffering. The Use of Artificial Intelligence in Toxicology — A Potential Driver for Reducing/Replacing Laboratory Animals in t	0
Dr Robert Combes (1946–2021)	0
Spotlight on Three Rs Progress	0