Atla-Alternatives to Laboratory Animals

Article	Citations
2023 Michael Balls Award	61
Resources Round-up	35
Coculture of ARPE-19 Cells and Porcine Neural Retina as an Ex Vivo Retinal Model	33
Conference Diary	28
A Low-fidelity Simulator for the Development of Vascular Ligation Skills	27
In Silico Prediction of Eye Irritation Using Hansen Solubility Parameters and Predicted pKa Values	25
Spotlight on Three Rs Progress	23
Conference Diary	21
In Vitro Dengue Virus Inhibition by Aqueous Extracts of Aegle marmelos, Munronia pinnata and Psidium guajava	20
Academic Training to Promote the Implementation of Alternative Methods and the Three Rs in the Field of Toxicology	13
Conference Diary	12
A History of the Development of Alternatives to Animals in Research and Testing	10
A Comparison of European Union and Turkish Reports on the Statistics of Experimental Animal Use in Toxicity Testing	10
Editorial	9
Conference Diary	9
JRC Summer School 2021	8
Editorial	8
A Human Cell-based Assay to Assess the Induction of Vasculature Formation for Non-genotoxic Carcinogenicity Testing Purposes: A Pilot Study	8
Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model	8
The Use of Human Tissues for Research: What Investigators Need to Know	7
Spotlight on Three Rs Progress	7
Editorial	7
The Evolution of Regulatory Toxicology: Where is the Gardener?	7
Editorial	7
Spotlight on Three Rs Progress	6

Comparison of Long-term Human Precision-cut Lung Slice Culture Methodology and Response to Challenge: An Argument for Standardisation	6
Spotlight on Three Rs Progress	6
Editorial	6
An Accessible Nephrectomy and Cystotomy Simulator for Use in Teaching Small Animal Surgery	6
Resources Round-up	5
An Evaluation of Different Types of Peptone as Partial Substitutes for Animal-derived Serum in Vero Cell Culture	5
The VEGAHUB Platform: The Philosophy and the Tools	5
Conference Diary	4
Accelerating Animal Replacement: How Universities Can Lead — Results of a One-Day Expert Workshop in Zurich, Switzerland	4
Case Studies Exemplifying the Transition to Animal Component-free Cell Culture	4
Resources Round-up	4
The Safety Assessment of Cosmetic Perfumes by Using In Chemico and In Vitro Methods in Combination with GC-MS/MS Analysis	4
Editorial	4
Spotlight on Three Rs Progress	4
Editorial	3
Is UK Animal Research Governance Facing a ‘New Normal’? Considering the Risks and Benefits of ‘Going Online’	3
Resources Round-up	3
Editorial	3
Thanks to Reviewers	3
Spotlight on Three Rs Progress	3
Spotlight on Three Rs Progress	3
Spotlight on Three Rs Progress	3
Cigarette Smoke Constituents and Nicotine Differentially Affect Cytokine Production by Human Macrophages Stimulated by TLR Ligands In Vitro: Considerations for a Standardised Protocol	3
JRC Summer School on Non-animal Approaches in Science, May 2021	3
Adapting to Changes in Publishing When Searching for Alternatives and Reporting on Animal Research: A Librarian’s Perspective	3
Conference Diary	2
Conference Diary	2
Editorial	2
Barriers to the Use of Recombinant Bacterial Endotoxins Test Methods in Parenteral Drug, Vaccine and Device Safety Testing	2
Report of the First ONTOX Hackathon: Hack to Save Lives and Avoid Animal Suffering. The Use of Artificial Intelligence in Toxicology — A Potential Driver for Reducing/Replacing Laboratory Animals in t	2
The Development and Evaluation of Brain and Heart Cell Lines from a Marine Fish for Use in Xenobiotic-Induced Cytotoxicity Testing	2
Conference Diary	2
The Use of MPS in Three Rs and Regulatory Applications: Perspectives From Developers on Stakeholder Responsibilities	2
Chemicals 2.0 and Why We Need to Bypass the Gold Standard in Regulatory Toxicology	2
Resources Round-up	2
The Effects of Urolithin B and Auraptene on Quinolinic Acid-induced Toxicity in the SH-SY5Y Neuroblastoma Cell Line	2
Spotlight on Three Rs Progress	2
Towards More Human and Humane Testing: The Role of the Device Supplier Industry	2
Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against Mycobacterium tuberculosis	2
Upholding the EU's Commitment to ‘Animal Testing as a Last Resort' Under REACH Requires a Paradigm Shift in How We Assess Chemical Safety to Close the Gap Between Regulatory Testing and Modern Safety	2
Editorial	1
A Novel Ex Vivo Blinking Method for Comparing the Corneal Residence Time of New Shampoo Formulations	1
Dr Robert Combes (1946–2021)	1
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders	1
The Use of Simulators for Teaching Practical Clinical Skills to Veterinary Students — A Review	1
A Short History of the Consideration of Sex Differences in Biomedical Research — Lessons for the In Vitro Community from Animal Models and Human Clinical Trials	1
Evaluation of a Low-cost Renal Simulator for the Diagnostic Ultrasound Training of Veterinary Medicine Students	1
Conference Diary	1
Spotlight on Three Rs Progress	1
The Current Status and Work of Three Rs Centres and Platforms in Europe*	1

Introducing the COST Action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE)	1
A Comparison of Mesenchymal Stem Cell-derived Hepatocyte-like Cells and HepG2 Cells for Use in Drug-Induced Liver Injury Studies	1
A New ATLA Associate Editor	1
Conference Diary	1
Resources Round-up	1
Conference Diary	1
The Use of an In Chemico Digestibility Assay to Reduce the In Vivo Fish Bioaccumulation Testing of Nanomaterials	1
EURL ECVAM Activities	1
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Second International Conference on 3Rs Research and Progress, Hyderabad, 2021	1
Development of Sensitive In Vitro Protocols for the Biocompatibility Testing of Medical Devices and Pharmaceuticals Intended for Contact with the Eyes: Acute Irritation and Phototoxicity Assess	1
Spotlight on Three Rs Progress	1
Assessment of a Low-cost Canine Uterine Simulator as a Tool for Teaching the Ovariohysterectomy Technique to Veterinary Students	1
Corrigendum to Report of the First ONTOX Hackathon: Hack to Save Lives and Avoid Animal Suffering. The Use of Artificial Intelligence in Toxicology — A Potential Driver for Reducing/Replacing Laborato	1
Recent ATLA Awards	1
It’s Time to Include Harm to Humans in Harm–Benefit Analysis — But How to Do It, That is the Question	1
Progress and Remaining Opportunities to Increase the Use of Animal-free Antibodies in the USA	1
Editorial	1
Spotlight on Three Rs Progress	1
The Use of 3-D Models of Echocardiographic Imaging Planes for Teaching Echocardiography Techniques for Use in Dogs and Cats	1
Resources Round-up	1
2022 Michael Balls Award	0
Use of the Allium cepa Model to Assess the Cytogenotoxicity of Luffariella herdmani Marine Sponge Extract	0
Transparency in Non-Technical Project Summaries to Promote the Three Rs in Respiratory Disease Research	0
Resources Round-up	0
Reviewing Current Guidance for the ‘R’ of Replacement and Rethinking it with the ‘Replacement Checklist’	0
Conference Diary	0
Determination of the Microinjected Cytosolic Concentration by Using Mathematical Models of Fluid Dynamics	0
Poor Translatability of Biomedical Research Using Animals — A Narrative Review	0
A Cytotoxicity Assay as an Alternative to the Murine Model for the Potency Testing of Bothrops jararaca Venom and Antivenom: An Intralaboratory Pre-validation Study	0
Biomedical Research Must Change — But a Shift Toward Human-specific Research Methods Is Only Part of What Is Needed	0
Celebrating Professor Horst Spielmann’s 80th Birthday	0
Editorial	0
An Evaluation of the Replacement of Animal-derived Biomaterials in Human Primary Cell Culture	0
Calling all students and early-career researchers — Join us for the second Summer School on Innovative Approaches in Science!	0
Resources Round-up	0
Optimisation of Conditions for the Formation of Spheroids of Head and Neck Squamous Cell Carcinoma Cell Lines for Use as Animal Alternatives	0
Editorial	0
The Rise of Three Rs Centres and Platforms in Europe*	0
Resources Round-up	0
Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance	0
The 3Ranker: An AI-based Algorithm for Finding Non-animal Alternative Methods	0
Editorial	0
Poster Prizes 2021	0
Conference Diary	0
2021 Michael Balls Award	0
Conference Diary	0
It’s Time to Review the Three Rs, to Make them More Fit for Purpose in the 21st Century	0
A History of the Development of Alternatives to Animals in Research and Testing	0
Rethinking the Three Rs: Growing Momentum Toward a New Gold Standard in Australian Research	0
The Accomplishments of KoCVAM in the Development and Implementation of Alternative Methods in Korea	0
Biobank Personnel — The Key to its Success	0
Conference Diary	0
Brazilian National Network of Alternative Methods (RENAMA) 10th Anniversary: Meeting of the Associated Laboratories, May 2022	0
Resources Round-up	0
Educators’ Views on the Use of Dissection and Dissection Alternatives in American Biology Classrooms	0
Thanks to Reviewers	0
Conference Diary	0
Evaluating the Impact of Hair Care Product Exposure on Hair Follicle and Scalp Health	0
Spotlight on Three Rs Progress	0
Editorial	0
Cardiac Transcription Regulators Differentiate Human Umbilical Cord Mesenchymal Stem Cells into Cardiac Cells	0
Resources Round-up	0
Thanks to Reviewers	0
Editorial	0
Spotlight on Three Rs Progress	0
Development of Two Korean IACUC Guidance Documents to Foster Implementation of the Three Rs	0
Spotlight on Three Rs Progress	0
Curated Data In — Trustworthy In Silico Models Out: The Impact of Data Quality on the Reliability of Artificial Intelligence Models as Alternatives to Animal Testing	0
Spotlight on Three Rs Progress	0
Conference Diary	0
Permutation Tests Are a Useful Alternative Approach for Statistical Hypothesis Testing in Small Sample Sizes	0
Book Review: Zebrafish Model for Biomedical Research	0
The 19th FRAME Annual Lecture, November 2022: Safer Chemicals and Sustainable Innovation Will Be Achieved by Regulatory Use of Modern Safety Science, Not by More Animal Testing	0
Message from FRAME	0
ATLA Best Poster Award	0
In Silico Phototoxicity Prediction of Drugs and Chemicals by using Derek Nexus and QSAR Toolbox	0
Editorial	0
Spotlight on Three Rs Progress	0
The Numbers of Animals Used in Mexico for Scientific and Educational Purposes	0
Implementing the EURL ECVAM Recommendation on Non-Animal-Derived Antibodies in One EU Member State — Denmark	0

Spotlight on Three Rs Progress	0
Resources Round-up	0
Conference Diary	0
Dr Richard Clothier: FRAME Trustee, Founding Director of the FRAME Laboratory and ATLA Editorial Board Member	0
The In Vitro Evaluation of Preosteoblast Migration From 3-D-printed Scaffolds to Decontaminated Smooth and Minimally Rough Titanium Surfaces: A Pilot Study	0
Resources Round-up	0
Editorial	0
Editorial	0
Modelling the Sorafenib-resistant Liver Cancer Microenvironment by Using 3-D Spheroids	0
Optimisation of a Method for the Differentiation of Human Umbilical Cord-derived Mesenchymal Stem Cells Toward Renal Epithelial-like Cells	0
Chitosan–Calcium Aluminate as a Cell-homing Scaffold: Its Bioactivity Testing in a Microphysiological Dental Pulp Platform	0
Lessons for the Future of NAMs from History, Philosophy and Social Studies of Science	0
Resources Round-up	0
The Use of Artificial Intelligence for the Fast and Effective Identification of Three Rs-based Literature	0
In Silico Prediction of Human Clinical Pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an Established Benchmarking Data Set, a Modern Small Drug Data Set, and a Comparison with La	0
Resources Round-up	0
Alternatives to Laboratory Animals: Trends in Replacement and the Three Rs	0
Biomedical Research on Substances of Abuse: The Italian Case Study	0
Spotlight on Three Rs Progress	0
Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway	0
How to Foster ‘New Approach Methodology’ Toxicologists	0
The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside	0
Resources Round-up	0
Development of an In Vitro Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells	0
Resources Round-up	0
The Capability Maturity Model as a Measure of Culture of Care in Laboratory Animal Science	0
Conference Diary	0
Evaluating the Protective Effects of Thymoquinone on Methamphetamine-induced Toxicity in an In Vitro Model Based on Differentiated PC12 Cells	0
Conference Diary	0
Addressing Animal Welfare Issues in Fetal Blood Collection for Fetal Bovine Serum Production	0
Zebrafish Beyond the Bench: The ‘Plataforma Zebrafish Open Doors’ Programme	0
Conference Diary	0
Editorial	0
Resources Round-up	0
Resources Round-up	0
Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters	0
Journeying Through Journals: The Publishing Process and How to Maximise Research Impact	0
Editorial	0
Conference Diary	0
Key Challenges for In Vitro Testing of Tobacco Products for Regulatory Applications: Recommendations for the In Vitro Mouse Lymphoma Assay	0
A Systematic Review of Published Physiologically-based Kinetic Models and an Assessment of their Chemical Space Coverage	0
Resources Round-up	0
An Approach to Setting Vertebrate Animal-use Benchmarks for Agrochemical and GM Crop Testing to Facilitate Future Animal Reduction Efforts	0
Resources Round-up	0
Conference Diary	0
The Use of In Silico Methods to Identify and Assess Antigenic Regions Suitable for the Development of Peptide-based Pan-viral Vaccines	0
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022	0
Acute Toxicity Assays with the Artemia salina Model: Assessment of Variables	0
Spotlight on Three Rs Progress	0
Spotlight on Three Rs Progress	0
Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings	0
Spotlight on Three Rs Progress	0
Spotlight on Three Rs Progress	0
A History of Regulatory Animal Testing: What Can We Learn?	0
The Perceptions of Students and Lecturers on the Use of Animals in Biomedical Science Undergraduate Education in Brazil	0
Editorial	0
Spotlight on Three Rs Progress	0
Corrigendum to Case Studies Exemplifying the Transition to Animal Component-Free Cell Culture	0
Resources Round-up	0
Editorial	0
Thanks to Reviewers	0
Development of an Accessible Gene Expression Bioinformatics Pipeline to Study Driver Mutations of Colorectal Cancer	0
Ex Vivo Human Skin: An Alternative Test System for Skin Irritation and Corrosion Assays	0
2020 Michael Balls Award	0
Editorial	0