OOIR: Observatory of International Research

Papers

(The TQCC of Atla-Alternatives to Laboratory Animals is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
The Safety Assessment of Cosmetic Perfumes by Using In Chemico and In Vitro Methods in Combination with GC	166
Spotlight on Three Rs Progress	38
Spotlight on Three Rs Progress	26
Evaluation of the antinociceptive effects of gabapentin using Gromphadorhina portentosa as a non-vertebrate in vivo	19
The Use of Human Tissues for Research: What Investigators Need to Know	19
The Development of an Animal Product-free, Precision-cut Lung Slice Cryopreservation and Post-thaw Culture Method	18
Conference Diary	16
Combinatorial induction with valproic acid and fibroblast growth factor-9 enhances neural differentiation and cell fate commitment in adipose tissue-derived mesenchymal stem cells	16
Toxicological Profiling of Potential Shikimate Kinase Inhibitors Against Mycobacterium tuberculosis	13
Conference Diary	12
Progress and Remaining Opportunities to Increase the Use of Animal-free Antibodies in the USA	11
Development of Sensitive In Vitro Protocols for the Biocompatibility Testing of Medical Devices and Pharmaceuticals Intended for Contact with the Eyes: A	11
Conference Diary	11
Brazilian National Network of Alternative Methods (RENAMA) 10th Anniversary: Meeting of the Associated Laboratories, May 2022	11
Resources Round-up	10
A History of the Development of Alternatives to Animals in Research and Testing	10
Editorial	9
In Silico Prediction of Human Clinical Pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an Established Benchmarking Data Set, a Modern Small Drug Data Set, and	9
Resources Round-up	9
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders	9
Dr Manfred Liebsch: Former Head of ZEBET and ATLA Editorial Board Member	9
Editorial	8
Addressing Animal Welfare Issues in Fetal Blood Collection for Fetal Bovine Serum Production	7
Reviewing Current Guidance for the ‘R’ of Replacement and Rethinking it with the ‘Replacement Checklist’	7
Editorial	7

The 19th FRAME Annual Lecture, November 2022: Safer Chemicals and Sustainable Innovation Will Be Achieved by Regulatory Use of Modern Safety Science, Not by More Animal Testing	7
2021 Michael Balls Award	7
Editorial	7
The impossible made possible through the use of New Approach Methodologies: Dermal safety assessment of potential insect repellent or insecticidal active ingredients using a high-throughput approach t	6
Spotlight on Three Rs progress	6
Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway	6
Resources Round-up	6
Spotlight on Three Rs Progress	6
Synthetic substrates as alternatives to bovine enamel in restorative dental materials research — A review	5
Editorial	5
The Numbers of Animals Used in Mexico for Scientific and Educational Purposes	5
Spotlight on Three Rs Progress	5
Thanks to Reviewers	5
Development of Two Korean IACUC Guidance Documents to Foster Implementation of the Three Rs	5
A Cytotoxicity Assay as an Alternative to the Murine Model for the Potency Testing of Bothrops jararaca Venom and Antivenom: An Intralaboratory Pre-valid	5
Book Review: Lab dog: A beagle and his human investigate the surprising world of animal research Melanie D.G. Kaplan (2025). Lab Dog: A Beagle and His Human Investigate the Surprising World of Animal	4
Corrigendum to Case Studies Exemplifying the Transition to Animal Component-Free Cell Culture	4
Editorial	4
Editorial	4
Optimisation of a Method for the Differentiation of Human Umbilical Cord-derived Mesenchymal Stem Cells Toward Renal Epithelial-like Cells	4
Accelerating Animal Replacement: How Universities Can Lead — Results of a One-Day Expert Workshop in Zurich, Switzerland	4
Case Studies Exemplifying the Transition to Animal Component-free Cell Culture	4
Resources Round-up	4
Editorial	4
Human NT2/D1-derived early neural progenitor cells immobilised in alginate microfibres as an in vitro 3D system for neurotoxicity testing	4
Lessons for the Future of NAMs from History, Philosophy and Social Studies of Science	3
The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside	3
The Current Status and Work of Three Rs Centres and Platforms in Europe*	3
Editorial	3
Determining the pathogenicity of uropathogenic Escherichia coli strains in the Galleria mellonella larvae	3
Spotlight on Three Rs Progress	3
Replacing immunisation-dependent antibody reagent production: Challenges under the UK Replacing Animals in Science	3
Introducing the COST Action ‘Improving the Quality of Biomedical Science with 3Rs Concepts’ (IMPROVE)	3
Editorial	3