OOIR: Observatory of International Research

Papers

(The TQCC of Atla-Alternatives to Laboratory Animals is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
A Review of In Silico Tools as Alternatives to Animal Testing: Principles, Resources and Applications	100
Upholding the EU's Commitment to ‘Animal Testing as a Last Resort' Under REACH Requires a Paradigm Shift in How We Assess Chemical Safety to Close the Gap Between Regulatory Testing and Modern Safety	23
Curated Data In — Trustworthy In Silico Models Out: The Impact of Data Quality on the Reliability of Artificial Intelligence Models as Alternatives to Animal Testing	21
Poor Translatability of Biomedical Research Using Animals — A Narrative Review	21
Some Reasons Why Preclinical Studies of Psychiatric Disorders Fail to Translate: What Can Be Rescued from the Misunderstanding and Misuse of Animal ‘Models’?	19
A Systematic Review of Published Physiologically-based Kinetic Models and an Assessment of their Chemical Space Coverage	19
The Use of Simulators for Teaching Practical Clinical Skills to Veterinary Students — A Review	17
In Silico Prediction of Human Clinical Pharmacokinetics with ANDROMEDA by Prosilico: Predictions for an Established Benchmarking Data Set, a Modern Small Drug Data Set, and a Comparison with La	17
A History of Regulatory Animal Testing: What Can We Learn?	14
Evaluation of the Influence of Astrocytes on In Vitro Blood–Brain Barrier Models	14
The Rise of Three Rs Centres and Platforms in Europe*	13
Farm Animal-derived Models of the Intestinal Epithelium: Recent Advances and Future Applications of Intestinal Organoids	12
The VEGAHUB Platform: The Philosophy and the Tools	12
The Use of In Silico Tools for the Toxicity Prediction of Potential Inhibitors of SARS-CoV-2	10
Alternatives to Laboratory Animals: Trends in Replacement and the Three Rs	9
Prediction of Human Lethal Doses and Concentrations of MEIC Chemicals from Rodent LD₅₀ Values: An Attempt to Make Some Reparation	9
Modulating the Barrier Function of Human Alveolar Epithelial (hAELVi) Cell Monolayers as a Model of Inflammation	8
The Evolution of Regulatory Toxicology: Where is the Gardener?	7
Development of an Accessible Gene Expression Bioinformatics Pipeline to Study Driver Mutations of Colorectal Cancer	6
Comparison of Long-term Human Precision-cut Lung Slice Culture Methodology and Response to Challenge: An Argument for Standardisation	6
It’s Time to Include Harm to Humans in Harm–Benefit Analysis — But How to Do It, That is the Question	6
Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings	6
The Current Status and Work of Three Rs Centres and Platforms in Europe*	6
The 19th FRAME Annual Lecture, November 2022: Safer Chemicals and Sustainable Innovation Will Be Achieved by Regulatory Use of Modern Safety Science, Not by More Animal Testing	5
Addressing Animal Welfare Issues in Fetal Blood Collection for Fetal Bovine Serum Production	5

Ex Vivo Human Skin: An Alternative Test System for Skin Irritation and Corrosion Assays	5
Biobank Personnel — The Key to its Success	5
Case Studies Exemplifying the Transition to Animal Component-free Cell Culture	5
The Use of Artificial Intelligence for the Fast and Effective Identification of Three Rs-based Literature	5
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Third International Conference on 3Rs Research and Progress, Vishakhapatnam, 2022	5
Biomedical Research Must Change — But a Shift Toward Human-specific Research Methods Is Only Part of What Is Needed	4
Coculture of ARPE-19 Cells and Porcine Neural Retina as an Ex Vivo Retinal Model	4
The First Rehoming of Laboratory Beagles in Finland: The Complete Process from Socialisation Training to Follow-up	4
Advances in Animal Models and Cutting-Edge Research in Alternatives: Proceedings of the Second International Conference on 3Rs Research and Progress, Hyderabad, 2021	4
Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters	4
The Effects of Urolithin B and Auraptene on Quinolinic Acid-induced Toxicity in the SH-SY5Y Neuroblastoma Cell Line	4
The Use of Human Tissues for Research: What Investigators Need to Know	3
Biomedical Research on Substances of Abuse: The Italian Case Study	3
A Comparison of Mesenchymal Stem Cell-derived Hepatocyte-like Cells and HepG2 Cells for Use in Drug-Induced Liver Injury Studies	3
The In Vitro Evaluation of Preosteoblast Migration From 3-D-printed Scaffolds to Decontaminated Smooth and Minimally Rough Titanium Surfaces: A Pilot Study	3
Culture of Care Enhancement in Egypt: The Impact of Laboratory Animal Science Training on Participants’ Attitudes	3
Cardiac Transcription Regulators Differentiate Human Umbilical Cord Mesenchymal Stem Cells into Cardiac Cells	3
The Implementation of the Three Rs in Regulatory Toxicity and Biosafety Assessment: The Indian Perspective	3
Qualitative and Quantitative Analysis of Certain Aspects of the Cytotoxic and Genotoxic Hazard of Hospital Wastewaters by Using a Range of In Vitro Assays	2
The Use of 3-D Models of Echocardiographic Imaging Planes for Teaching Echocardiography Techniques for Use in Dogs and Cats	2
A Short History of the Consideration of Sex Differences in Biomedical Research — Lessons for the In Vitro Community from Animal Models and Human Clinical Trials	2
An Evaluation of Different Types of Peptone as Partial Substitutes for Animal-derived Serum in Vero Cell Culture	2
In Vitro Dengue Virus Inhibition by Aqueous Extracts of Aegle marmelos, Munronia pinnata and Psidium guajava	2
Optimisation of Conditions for the Formation of Spheroids of Head and Neck Squamous Cell Carcinoma Cell Lines for Use as Animal Alternatives	2
Development of an In Vitro Sensitisation Test Using a Coculture System of Human Bronchial Epithelium and Immune Cells	2
The Application of New Approach Methodologies in Respiratory Disease Research: Their Role in Improving Translational Medicine from Bench to Bedside	2
Adapting to Changes in Publishing When Searching for Alternatives and Reporting on Animal Research: A Librarian’s Perspective	2
The Safety Assessment of Cosmetic Perfumes by Using In Chemico and In Vitro Methods in Combination with GC-MS/MS Analysis	2
Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model	2
Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance	2
Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway	2
Culture Conditions Affect Chemical-Induced Developmental Toxicity In Vitro: The Case of Folic Acid, Methionine and Methotrexate in the Neural Embryonic Stem Cell Test	2
Towards More Human and Humane Testing: The Role of the Device Supplier Industry	2
A Low-fidelity Simulator for the Development of Vascular Ligation Skills	2