EMBO Journal

Article	Citations
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	1065
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease	483
PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase	286
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization	174
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells	171
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling	168
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4+ T‐cells for the treatment of Hyper IgM1	164
Nascent polypeptide within the exit tunnel stabilizes the ribosome to counteract risky translation	155
Cancer‐associated mutations in VAV1 trigger variegated signaling outputs and T‐cell lymphomagenesis	148
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs	131
Lipid metabolism: new twists to the Yin and Yang of PKM2 in cancer	130
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	126
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	124
PKM2‐TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability	106
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	102
The plant noncoding transcriptome: a versatile environmental sensor	101
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	100
Do we still need animals? Surveying the role of animal‐free models in Alzheimer’s and Parkinson’s disease research	99
Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis	99
In vivo reduction of RAD51‐mediated homologous recombination triggers aging but impairs oncogenesis	98
PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks	96
TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses	95
Presynaptic targeting of botulinum neurotoxin type A requires a tripartitePSG‐Syt1‐SV2plasma membrane nanocluster for synaptic vesicle entry	93
High‐resolution analysis of the conformational transition of pro‐apoptotic Bak at the lipid membrane	93
Distinct roles of α‐ and β‐tubulin polyglutamylation in controlling axonal transport and in neurodegeneration	90

CROP: a retromer‐PROPPIN complex mediating membrane fission in the endo‐lysosomal system	89
Torsin and NEP1R1‐CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid‐dependent and lipid‐independent mechanisms	87
Single‐cell transcriptomics of LepR‐positive skeletal cells reveals heterogeneous stress‐dependent stem and progenitor pools	85
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	85
The SMC5/6 complex recruits the PAF1 complex to facilitate DNA double‐strand break repair in Arabidopsis	76
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6	75
Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane	75
IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	75
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	73
Eating your mitochondria—when too much of a good thing turns bad	71
A network of small RNAs regulates sporulation initiation in Clostridioides difficile	71
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates	70
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori	70
Evolutionary adaptation of the protein folding pathway for secretability	69
Structure of cytosine transport protein CodB provides insight into nucleobase‐cation symporter 1 mechanism	69
CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma	67
ZZ domains keep cytosol to vacuole delivery whiZZing along	66
The glycine arginine‐rich domain of the RNA‐binding protein nucleolin regulates its subcellular localization	65
Gut colonization by Bacteroides requires translation by an EF‐G paralog lacking GTPase activity	65
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity	65
Regulated splicing of large exons is linked to phase‐separation of vertebrate transcription factors	63
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation	60
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease	59
Sir3 heterochromatin protein promotes non‐homologous end joining by direct inhibition of Sae2	59
Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity	59
Interferon‐inducible phospholipids govern IFITM3‐dependent endosomal antiviral immunity	56
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome	55
Strigolactones promote plant freezing tolerance by releasing the WRKY41‐mediated inhibition of CBF/DREB1 expression	55
The Hippo pathway drives the cellular response to hydrostatic pressure	54
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona	54
MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation	53
Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break formation	53
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	53
DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion	53
Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis	52
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer	52
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma	52
Dynamic EMT: a multi‐tool for tumor progression	52
Autophagy power expands: fuse those cells!	52
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis	52
Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation	52
Ribosome biogenesis factors—from names to functions	52
The CTLA‐4 immune checkpoint protein regulates PD‐L1:PD‐1 interaction via transendocytosis of its ligand CD80	52
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization	52
LAMTOR1 inhibition of TRPML1‐dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function	51
Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans	51
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions	50
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation	50
Interactomes of SARS‐CoV‐2 and human coronaviruses reveal host factors potentially affecting pathogenesis	50
ARF2‐PIF5 interaction controls transcriptional reprogramming in the ABS3‐mediated plant senescence pathway	50

DRP1 interacts directly with BAX to induce its activation and apoptosis	49
Structure and mechanism of a eukaryotic ceramide synthase complex	49
BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response	49
Living a longer life: unique lessons from the naked mole‐rat blood system	48
Quorum sensing governs collective dendritic cell activation in vivo	48
Dynamic regulation of mitotic ubiquitin ligase APC/C by coordinated Plx1 kinase and PP2A phosphatase action on a flexible Apc1 loop	47
IκB kinase‐α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage‐based anticancer therapy	46
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	46
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus	46
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1	46
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons	46
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy	46
Histone retention preserves epigenetic marks during heat stress‐induced transcriptional memory in plants	45
c‐Maf enforces cytokine production and promotes memory‐like responses in mouse and human type 2 innate lymphoid cells	45
Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response	44
Die another day: phytosulfokine at the molecular trade‐off between growth and defense in plants	44
PIF7‐mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis	44
Subcellular localization of Type VI secretion system assembly in response to cell–cell contact	44
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit	43
Protein synthesis control in cancer: selectivity and therapeutic targeting	43
C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation	43
Cancer evolution: Darwin and beyond	43
Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation	42
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation	42
DNA asymmetry promotes SUMO modification of the single‐stranded DNA‐binding protein RPA	41
Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement	40
Stress‐dependent macromolecular crowding in the mitochondrial matrix	40
Salicylic acid‐activated BIN2 phosphorylation of TGA3 promotes Arabidopsis PR gene expression and disease resistance	40
Evidence for existence of an apoptosis‐inducing BH3‐only protein, sayonara, in Drosophila	40
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy	39
Seeing eye to eye: photoreceptors employ nanotube‐like connections for material transfer	39
Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production	39
The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast	39
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6‐methyladenosine‐containing RNA virus	39
Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway	38
LUBAC and NF‐κB trigger a nuclear response from mitochondria	38
Reply to “An alternative miRISC targets a cancer‐associated coding sequence mutation in FOXL2”	38
CRIP1 suppresses BBOX1‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma	38
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	37
The cellular modifier MOAG‐4/SERF drives amyloid formation through charge complementation	37
Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes	37
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development	37
R‐spondin signaling in the stomach: isthmal Lgr4 rules	37
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms	36
Nix interacts with WIPI2 to induce mitophagy	36
Extra centrosomes induce PIDD1‐mediated inflammation and immunosurveillance	36
Stem cells “aclymatise” to regenerate the blood system	36
TFEB‐dependent lysosome biogenesis is required for senescence	36
The needs of a synapse—How local organelles serve synaptic proteostasis	36
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	36
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity	36
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure	36
The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis	35
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	35
Multi‐modal adaptor‐clathrin contacts drive coated vesicle assembly	35
A CRMP4‐dependent retrograde axon‐to‐soma death signal in amyotrophic lateral sclerosis	35
PABP prevents the untimely decay of select mRNA populations in human cells	35
Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint	35
Binary organization of epidermal basal domains highlights robustness to environmental exposure	34
E‐cadherin mediates apical membrane initiation site localisation duringde novopolarisation of epithelial cavities	34
A critical period of prehearing spontaneous Ca2+ spiking is required for hair‐bundle maintenance in inner hair cells	34
ER‐anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6	34
Mitochondria and peroxisomes are NIXed for clearance	33
The CRL4 DCAF1 cullin‐RING ubiquitin ligase is activated following a switch in oligomerization state	33
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	33
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	33
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding	33
Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration	33
SHP‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	32
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	32
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	32
Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila	32
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	32
Msps governs acentrosomal microtubule assembly and reactivation of quiescent neural stem cells	32
Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin	32
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	31
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	31
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis	31
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis	31
The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading	31

Mammalian antiviral RNAi is on the move	31
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	31
NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	31
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle	31
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	31
Deciphering functional tumor states at single‐cell resolution	30
Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells	30
Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines	30
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion	30
Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1	30
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	30
ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange	30
When yeast cells change their mind: cell cycle “Start” is reversible under starvation	30
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF‐α	29
Some viruses need to phase‐separate to replicate	29
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA‐mediated mitochondrial–nuclear communication	29
Quorum sensing componentry opens new lines of communication	29
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2	29
The TOR‐dependent phosphoproteome and regulation of cellular protein synthesis	29
Hold the fold: how delayed folding aids protein secretion	29
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells	29
Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing	29
Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease	29
A sudden collapse: the disaggregation of amyloid fibres	29
Maternal immune activation leads to defective brain blood vessels and intracerebral hemorrhages in male offspring	28
Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response	28
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses	28
Piwi–piRNA complexes induce stepwise changes in nuclear architecture at target loci	28
Microglial PD‐1 stimulation by astrocytic PD‐L1 suppresses neuroinflammation and Alzheimer’s disease pathology	28
Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol	28
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression	28
Disulfiram bolsters T‐cell anti‐tumor immunity through direct activation of LCK‐mediated TCR signaling	27
An alternative UPF1 isoform drives conditional remodeling of nonsense‐mediated mRNA decay	27
Fluc‐EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease	27
Fuel oxidation under the control of mitochondrial shape and dynamics	27
TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression	27
Molecular and structural mechanisms of ZZ domain‐mediated cargo selection by Nbr1	27
Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding	27
Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion	26
Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding	26
An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation	26
Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel	26
Phosphatidic acid–regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress	26
Pathogenic fungi neutralize plant‐derived ROS via Srpk1 deacetylation	26
STAT1 is required to establish but not maintain interferon‐γ‐induced transcriptional memory	26
The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases	25
Two Hippo signaling modules orchestrate liver size and tumorigenesis	25
3D imaging for driving cancer discovery	25
Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies	25
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component	25
microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes	25
AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5	25
Sweet‐talk in the time of cholera: host mucin negotiates peace with Vibrio cholerae	25
Ca 2+ signals in plant immunity	25
Fecal microbiota transplantation enhances cell therapy in a rat model of hypoganglionosis by SCFA‐induced MEK1/2 signaling pathway	24
Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome	24
Host cell egress of Brucella abortus requires BNIP3L‐mediated mitophagy	24
Mitotic checkpoint gene expression is tuned by codon usage bias	24
Spo13/MEIKIN ensures a Two‐Division meiosis by preventing the activation of APC/CAma1 at meiosis I	24
An accessory prefrontal cortex–thalamus circuit sculpts maternal behavior in virgin female mice	24
Creativity as an antidote to research becoming too predictable	24
The ion‐coupling mechanism of human excitatory amino acid transporters	24
Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor NLR immune receptors Rpi‐amr3 and Rpi‐amr1	24
You can “tail” them apart: paralog‐specific functions of CRL4B ubiquitin ligases during mitosis and brain development	24
LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation	24
Cryo‐EM structure of antibacterial efflux transporter QacA from Staphylococcus aureus reveals a novel extracellular loop with allosteric role	24
Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters	24
Regulation of mitochondrial proteostasis by the proton gradient	23
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection	23
Bacteria elicit a phage tolerance response subsequent to infection of their neighbors	23
Retromer oligomerization drives SNX‐BAR coat assembly and membrane constriction	23
Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes	23
Acetylation coordinates the crosstalk between carbon metabolism and ammonium assimilation in Salmonella enterica	23
MARCO + lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination	23
Nucleoporin foci are stress‐sensitive condensates dispensable for C. elegans nuclear pore assembly	23
Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness	23
Recycling of the actin monomer pool limits the lifetime of network turnover	23
Anti‐hsa‐miR‐59 alleviates premature senescence associated with Hutchinson‐Gilford progeria syndrome in mice	23
Vaginal bacterium Prevotella timonensis turns protective Langerhans cells into HIV‐1 reservoirs for virus dissemination	23
Auxin‐dependent regulation of cell division rates governs root thermomorphogenesis	23
T‐cell antigen recognition: catch‐as‐catch‐can or catch‐22?	23
Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency	23
Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse	23
The PAX5‐JAK2 translocation acts as dual‐hit mutation that promotes aggressive B‐cell leukemia via nuclear STAT5 activation	23
Translational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding	23
High‐throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory‐deprived cortical cholinergic VIP/CHAT neurons	23
Termination of STING responses is mediated via ESCRT‐dependent degradation	22
Epigenetic regulation limits competence of pluripotent stem cell‐derived oocytes	22
Rewiring phospholipid biosynthesis reveals resilience to membrane perturbations and uncovers regulators of lipid homeostasis	22
A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription	22
The BCL‐2 family member BID plays a role during embryonic development in addition to its BH3‐only protein function by acting in parallel to BAX, BAK	22
Tau target identification reveals NSF‐dependent effects on AMPA receptor trafficking and memory formation	22
Oxidative stress protein Oxr1 promotes V‐ATPase holoenzyme disassembly in catalytic activity‐independent manner	22
The ASC‐1 complex promotes translation initiation by scanning ribosomes	21
Adaptive pathfinding by nucleokinesis during amoeboid migration	21