EMBO Journal

Article	Citations
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization	176
Lipid metabolism: new twists to the Yin and Yang of PKM2 in cancer	170
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells	166
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease	155
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	144
Cancer‐associated mutations in VAV1 trigger variegated signaling outputs and T‐cell lymphomagenesis	133
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	132
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs	120
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling	118
Nascent polypeptide within the exit tunnel stabilizes the ribosome to counteract risky translation	118
Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis	114
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	109
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	108
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	105
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4+ T‐cells for the treatment of Hyper IgM1	103
PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase	100
The plant noncoding transcriptome: a versatile environmental sensor	99
Single‐cell transcriptomics of LepR‐positive skeletal cells reveals heterogeneous stress‐dependent stem and progenitor pools	91
Do we still need animals? Surveying the role of animal‐free models in Alzheimer’s and Parkinson’s disease research	90
CROP: a retromer‐PROPPIN complex mediating membrane fission in the endo‐lysosomal system	89
TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses	84
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	84
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	84
Presynaptic targeting of botulinum neurotoxin type A requires a tripartitePSG‐Syt1‐SV2plasma membrane nanocluster for synaptic vesicle entry	83
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6	81

In vivo reduction of RAD51‐mediated homologous recombination triggers aging but impairs oncogenesis	79
The SMC5/6 complex recruits the PAF1 complex to facilitate DNA double‐strand break repair in Arabidopsis	79
IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	78
Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane	77
Regulated splicing of large exons is linked to phase‐separation of vertebrate transcription factors	75
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity	75
Sir3 heterochromatin protein promotes non‐homologous end joining by direct inhibition of Sae2	74
Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break formation	74
Evolutionary adaptation of the protein folding pathway for secretability	74
A network of small RNAs regulates sporulation initiation in Clostridioides difficile	74
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori	68
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona	67
Interferon‐inducible phospholipids govern IFITM3‐dependent endosomal antiviral immunity	65
Eating your mitochondria—when too much of a good thing turns bad	65
The Hippo pathway drives the cellular response to hydrostatic pressure	64
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation	64
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	63
Structure of cytosine transport protein CodB provides insight into nucleobase‐cation symporter 1 mechanism	63
Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity	62
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease	61
DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion	60
Ribosome biogenesis factors—from names to functions	60
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates	60
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome	60
Gut colonization by Bacteroides requires translation by an EF‐G paralog lacking GTPase activity	59
MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation	58
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer	57
Strigolactones promote plant freezing tolerance by releasing the WRKY41‐mediated inhibition of CBF/DREB1 expression	57
LAMTOR1 inhibition of TRPML1‐dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function	57
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis	56
Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis	55
Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation	55
Autophagy power expands: fuse those cells!	54
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation	54
The CTLA‐4 immune checkpoint protein regulates PD‐L1:PD‐1 interaction via transendocytosis of its ligand CD80	54
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions	54
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma	53
ARF2‐PIF5 interaction controls transcriptional reprogramming in the ABS3‐mediated plant senescence pathway	53
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization	51
DRP1 interacts directly with BAX to induce its activation and apoptosis	51
Die another day: phytosulfokine at the molecular trade‐off between growth and defense in plants	50
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	49
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus	48
BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response	48
IκB kinase‐α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage‐based anticancer therapy	47
PIF7‐mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis	47
Evidence for existence of an apoptosis‐inducing BH3‐only protein, sayonara, in Drosophila	47
Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production	46
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy	46
Subcellular localization of Type VI secretion system assembly in response to cell–cell contact	46

Histone retention preserves epigenetic marks during heat stress‐induced transcriptional memory in plants	45
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1	44
Living a longer life: unique lessons from the naked mole‐rat blood system	44
Structure and mechanism of a eukaryotic ceramide synthase complex	44
Salicylic acid‐activated BIN2 phosphorylation of TGA3 promotes Arabidopsis PR gene expression and disease resistance	44
Protein synthesis control in cancer: selectivity and therapeutic targeting	43
Stress‐dependent macromolecular crowding in the mitochondrial matrix	43
Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response	43
C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation	42
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation	42
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit	42
Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement	42
Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes	40
CRIP1 suppresses BBOX1‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma	40
LUBAC and NF‐κB trigger a nuclear response from mitochondria	40
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons	40
c‐Maf enforces cytokine production and promotes memory‐like responses in mouse and human type 2 innate lymphoid cells	40
R‐spondin signaling in the stomach: isthmal Lgr4 rules	40
The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast	40
TFEB‐dependent lysosome biogenesis is required for senescence	40
Seeing eye to eye: photoreceptors employ nanotube‐like connections for material transfer	40
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy	39
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	39
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development	39
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure	39
Extra centrosomes induce PIDD1‐mediated inflammation and immunosurveillance	38
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity	38
The needs of a synapse—How local organelles serve synaptic proteostasis	38
The cellular modifier MOAG‐4/SERF drives amyloid formation through charge complementation	38
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6‐methyladenosine‐containing RNA virus	38
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	37
Nix interacts with WIPI2 to induce mitophagy	37
PABP prevents the untimely decay of select mRNA populations in human cells	37
Stem cells “aclymatise” to regenerate the blood system	37
E‐cadherin mediates apical membrane initiation site localisation duringde novopolarisation of epithelial cavities	36
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	36
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	36
A critical period of prehearing spontaneous Ca2+ spiking is required for hair‐bundle maintenance in inner hair cells	36
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding	36
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms	35
The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading	35
Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint	35
Binary organization of epidermal basal domains highlights robustness to environmental exposure	35
Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration	35
The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis	35
SHP‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	35
Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila	35
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	34
Mitochondria and peroxisomes are NIXed for clearance	34
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	34
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	34
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	34
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle	34
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion	34
Mammalian antiviral RNAi is on the move	34
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis	33
Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells	33
NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	33
Deciphering functional tumor states at single‐cell resolution	33
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF‐α	32
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	32
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis	32
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	32
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	32
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	32
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	32
Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1	31
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells	31
When yeast cells change their mind: cell cycle “Start” is reversible under starvation	31
A sudden collapse: the disaggregation of amyloid fibres	31
Quorum sensing componentry opens new lines of communication	31
Hold the fold: how delayed folding aids protein secretion	31
Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines	31
Microglial PD‐1 stimulation by astrocytic PD‐L1 suppresses neuroinflammation and Alzheimer’s disease pathology	30
Two Hippo signaling modules orchestrate liver size and tumorigenesis	30
Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing	30
Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response	30
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression	30
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA‐mediated mitochondrial–nuclear communication	30
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2	30

An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation	30
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component	29
Maternal immune activation leads to defective brain blood vessels and intracerebral hemorrhages in male offspring	29
Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion	29
Fuel oxidation under the control of mitochondrial shape and dynamics	29
Disulfiram bolsters T‐cell anti‐tumor immunity through direct activation of LCK‐mediated TCR signaling	29
Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel	29
An alternative UPF1 isoform drives conditional remodeling of nonsense‐mediated mRNA decay	28
AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5	28
Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding	28
3D imaging for driving cancer discovery	28
STAT1 is required to establish but not maintain interferon‐γ‐induced transcriptional memory	28
The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases	28
Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies	28
Ca 2+ signals in plant immunity	28
Phosphatidic acid–regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress	28
TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression	28
Pathogenic fungi neutralize plant‐derived ROS via Srpk1 deacetylation	28
Sweet‐talk in the time of cholera: host mucin negotiates peace with Vibrio cholerae	27
Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome	27
Retromer oligomerization drives SNX‐BAR coat assembly and membrane constriction	27
The ion‐coupling mechanism of human excitatory amino acid transporters	27
Spo13/MEIKIN ensures a Two‐Division meiosis by preventing the activation of APC/CAma1 at meiosis I	27
Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters	27
Host cell egress of Brucella abortus requires BNIP3L‐mediated mitophagy	27
microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes	27
Creativity as an antidote to research becoming too predictable	27
You can “tail” them apart: paralog‐specific functions of CRL4B ubiquitin ligases during mitosis and brain development	27
Anti‐hsa‐miR‐59 alleviates premature senescence associated with Hutchinson‐Gilford progeria syndrome in mice	27
An accessory prefrontal cortex–thalamus circuit sculpts maternal behavior in virgin female mice	27
Mitotic checkpoint gene expression is tuned by codon usage bias	26
LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation	26
Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse	26
Cryo‐EM structure of antibacterial efflux transporter QacA from Staphylococcus aureus reveals a novel extracellular loop with allosteric role	26
Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor NLR immune receptors Rpi‐amr3 and Rpi‐amr1	26
Fecal microbiota transplantation enhances cell therapy in a rat model of hypoganglionosis by SCFA‐induced MEK1/2 signaling pathway	26
Bacteria elicit a phage tolerance response subsequent to infection of their neighbors	26
Recycling of the actin monomer pool limits the lifetime of network turnover	26
RNase H2 degrades toxic RNA:DNA hybrids behind stalled forks to promote replication restart	25
Auxin‐dependent regulation of cell division rates governs root thermomorphogenesis	25
T‐cell antigen recognition: catch‐as‐catch‐can or catch‐22?	25
Translational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding	25
High‐throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory‐deprived cortical cholinergic VIP/CHAT neurons	25
Thiol reductive stress activates the hypoxia response pathway	25
A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans	25
Epigenetic regulation limits competence of pluripotent stem cell‐derived oocytes	25
Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness	25
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection	25
Nucleoporin foci are stress‐sensitive condensates dispensable for C. elegans nuclear pore assembly	25
Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency	25
A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription	25
Acetylation coordinates the crosstalk between carbon metabolism and ammonium assimilation in Salmonella enterica	25
Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes	25
Vaginal bacterium Prevotella timonensis turns protective Langerhans cells into HIV‐1 reservoirs for virus dissemination	24
Regulation of membrane fluidity by RNF145‐triggered degradation of the lipid hydrolase ADIPOR2	24
Tau target identification reveals NSF‐dependent effects on AMPA receptor trafficking and memory formation	24
MARCO + lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination	24
Termination of STING responses is mediated via ESCRT‐dependent degradation	24
Regulation of mitochondrial proteostasis by the proton gradient	24
Oxidative stress protein Oxr1 promotes V‐ATPase holoenzyme disassembly in catalytic activity‐independent manner	24
The BCL‐2 family member BID plays a role during embryonic development in addition to its BH3‐only protein function by acting in parallel to BAX, BAK	24
The PAX5‐JAK2 translocation acts as dual‐hit mutation that promotes aggressive B‐cell leukemia via nuclear STAT5 activation	24
Rewiring phospholipid biosynthesis reveals resilience to membrane perturbations and uncovers regulators of lipid homeostasis	24
Nucleic acid–protein condensates in innate immune signaling	23
The ASC‐1 complex promotes translation initiation by scanning ribosomes	23
Tau: a phase in the crowd	23
m6A is required for resolving progenitor identity during planarian stem cell differentiation	23
Adaptive pathfinding by nucleokinesis during amoeboid migration	23
NME6: ribonucleotide salvage sustains mitochondrial transcription	23
Infection and inflammation stimulate expansion of a CD74+ Paneth cell subset to regulate disease progression	23
Condensin pinches a short negatively supercoiled DNA loop during each round of ATP usage	23
ARFs get the BioID treatment: what have we been missing?	23
The adaptive strategies of cells in the face of CIN	23
Two Hippo signaling modules orchestrate liver size and tumorigenesis	23
Making liver cancer cells go ARGh!	23
The mitochondrial ATP synthase as an ATP consumer—a surprising therapeutic target	22
The MASTL/PP2A cell cycle kinase‐phosphatase module restrains PI3K‐Akt activity in an mTORC1‐dependent manner	22
Suppression of Ca2+ signaling enhances melanoma progression	22
Dieter Wolf (1941–2023): a life dedicated to understanding protein quality control and the ubiquitin‐proteasome system	22
Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway	22
Phospholipid scramblase Xkr8 is required for developmental axon pruning via phosphatidylserine exposure	22
Promoter‐pervasive transcription causes RNA polymerase II pausing to boost DOG1 expression in response to salt	22
Extracellular vesicles and co‐isolated endogenous retroviruses from murine cancer cells differentially affect dendritic cells	22
Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns	22
ER exit sites take the strain	22
A Zn‐dependent structural transition of SOD1 modulates its ability to undergo phase separation	22
Dermal αSMA + myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production	22
Role of PCIF1‐mediated 5′‐cap N6‐methyladeonsine mRNA methylation in colorectal cancer and anti‐PD‐1 immunotherapy	22
AATF/Che‐1 localizes to paraspeckles and suppresses R‐loops accumulation and interferon activation in Multiple Myeloma	22
A systematic proximity ligation approach to studying protein‐substrate specificity identifies the substrate spectrum of the Ssh1 translocon	22
A tale of two Hippo pathway modules	22
Classics never get old: neurotransmitters shape human cortical interneuron migration	22
Barley GRIK1‐SnRK1 kinases subvert a viral virulence protein to upregulate antiviral RNAi and inhibit infection	22
Macrophage‐derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection	22
Mechanical forces impair antigen discrimination by reducing differences in T‐cell receptor/peptide–MHC off‐rates	21