EMBO Journal

Article	Citations
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4+ T‐cells for the treatment of Hyper IgM1	989
Regulation of membrane fluidity by RNF145‐triggered degradation of the lipid hydrolase ADIPOR2	461
PABP prevents the untimely decay of select mRNA populations in human cells	289
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	277
The ASC‐1 complex promotes translation initiation by scanning ribosomes	168
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	167
Infection and inflammation stimulate expansion of a CD74+ Paneth cell subset to regulate disease progression	163
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling	151
Binary organization of epidermal basal domains highlights robustness to environmental exposure	149
NDST3 deacetylates α‐tubulin and suppresses V‐ATPase assembly and lysosomal acidification	136
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells	121
Hematopoietic stem and progenitor cells integrate microbial signals to promote post‐inflammation gut tissue repair	116
Tubulin polyglutamylation differentially regulates microtubule‐interacting proteins	112
Systematic identification and characterization of repressive domains in Drosophila transcription factors	107
m6A is required for resolving progenitor identity during planarian stem cell differentiation	96
The goodies of chelated fat: iron‐regulated lipid droplet biogenesis precedes and preserves mitophagy	95
A CRMP4‐dependent retrograde axon‐to‐soma death signal in amyotrophic lateral sclerosis	94
miR‐124‐dependent tagging of synapses by synaptopodin enables input‐specific homeostatic plasticity	94
HASTY , the Arabidopsis EXPORTIN5 ortholog, regulates cell‐to‐cell and vascular microRNA movement	93
SPICE‐Met: profiling and imaging energy metabolism at the single‐cell level using a fluorescent reporter mouse	90
The plant noncoding transcriptome: a versatile environmental sensor	90
A tale of two inhibitors: diarylquinolines and squaramides	89
Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint	89
The adaptive strategies of cells in the face of CIN	88
Lipid metabolism: new twists to the Yin and Yang of PKM2 in cancer	87

Making liver cancer cells go ARGh!	86
ARFs get the BioID treatment: what have we been missing?	86
Stem cells “aclymatise” to regenerate the blood system	84
What (H)IF isoform matters? A deubiquitinase can tune the hypoxic response	81
APP substrate ectodomain defines amyloid‐β peptide length by restraining γ‐secretase processivity and facilitating product release	80
Suppressing toxic aggregates: let MIA do it!	72
Acquired stress resilience through bacteria‐to‐nematode interdomain horizontal gene transfer	72
Immune synaptopathies: how maternal immune activation impacts synaptic function during development	70
ER‐anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6	70
Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration	70
Characterization of naked mole‐rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits	69
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	69
The SAGA complex regulates early steps in transcription via its deubiquitylase module subunit USP22	66
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization	66
Genetic control of the pluripotency epigenome determines differentiation bias in mouse embryonic stem cells	65
Too much death can kill you: inhibiting intrinsic apoptosis to treat disease	65
Oxidative stress‐induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2	64
AMPK CA(R)Sts a new light on amino acid sensing	63
DNA‐PKcs and ATM modulate mitochondrial ADP‐ATP exchange as an oxidative stress checkpoint mechanism	63
ADPGK‐AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth	62
Nucleic acid–protein condensates in innate immune signaling	62
NME6: ribonucleotide salvage sustains mitochondrial transcription	62
PHGDH and cancer: new job for an old enzyme!	60
Cadherin‐mediated adhesion takes control	56
Cancer‐associated mutations in VAV1 trigger variegated signaling outputs and T‐cell lymphomagenesis	56
Changes in adenoviral chromatin organization precede early gene activation upon infection	54
Macrophage‐derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection	54
Cryo‐EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms	53
The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis	53
An engineered multicellular stem cell niche for the 3D derivation of human myogenic progenitors from iPSCs	53
High‐resolution mapping of function and protein binding in an RNA nuclear enrichment sequence	52
Tau: a phase in the crowd	52
Blood endothelial ALK1‐BMP4 signaling axis regulates adult hair follicle stem cell activation	51
Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV‐1 pathogenesis	50
Employing core regulatory circuits to define cell identity	50
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease	48
A heterotypic assembly mechanism regulates CHIP E3 ligase activity	48
E‐cadherin mediates apical membrane initiation site localisation duringde novopolarisation of epithelial cavities	48
Photoreceptor nanotubes mediate the in vivo exchange of intracellular material	47
A critical period of prehearing spontaneous Ca2+ spiking is required for hair‐bundle maintenance in inner hair cells	47
Multi‐modal adaptor‐clathrin contacts drive coated vesicle assembly	47
Sharpening the blades of the dentate gyrus: how adult‐born neurons differentially modulate diverse aspects of hippocampal learning and memory	47
Astrogenesis in the murine dentate gyrus is a life‐long and dynamic process	46
Calcium signals regulate the functional differentiation of thymic iNKT cells	46
Two Hippo signaling modules orchestrate liver size and tumorigenesis	46
Arabidopsis HEAT SHOCK FACTOR BINDING PROTEIN is required to limit meiotic crossovers and HEI10 transcription	46
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	46
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	46
MICa/b‐dependent activation of natural killer cells by CD64+ inflammatory type 2 dendritic cells contributes to autoimmunity	46
Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin	46

E2/E3‐independent ubiquitin‐like protein conjugation by Urm1 is directly coupled to cysteine persulfidation	46
Microglial TNFα orchestrates protein phosphorylation in the cortex during the sleep period and controls homeostatic sleep	45
Programmable C‐to‐U RNA editing using the human APOBEC3A deaminase	45
Nascent polypeptide within the exit tunnel stabilizes the ribosome to counteract risky translation	44
Transport unplugged: KCCs are regulated through an N‐terminal plug of the ion pathway	44
“Be sustainable”: EOSC‐Life recommendations for implementation of FAIR principles in life science data handling	44
PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522	44
Viral recognition and the antiviral interferon response	44
Regeneration of the human segmentation clock in somitoids in vitro	44
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms	43
Mammalian ATG8 proteins maintain autophagosomal membrane integrity through ESCRTs	43
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding	43
Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed	42
DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability	42
On the role of phase separation in the biogenesis of membraneless compartments	42
Ubiquitin‐targeted bacterial effectors: rule breakers of the ubiquitin system	42
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs	42
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	41
Cryo‐EM structures of perforin‐2 in isolation and assembled on a membrane suggest a mechanism for pore formation	41
PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase	41
A systematic proximity ligation approach to studying protein‐substrate specificity identifies the substrate spectrum of the Ssh1 translocon	41
Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans	41
Condensin pinches a short negatively supercoiled DNA loop during each round of ATP usage	41
Promoter‐pervasive transcription causes RNA polymerase II pausing to boost DOG1 expression in response to salt	40
BH3‐only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α	40
A small peptide inhibits siRNA amplification in plants by mediating autophagic degradation of SGS3/RDR6 bodies	40
Adaptive pathfinding by nucleokinesis during amoeboid migration	40
Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis	40
Loss of TDP‐43 oligomerization or RNA binding elicits distinct aggregation patterns	39
PKM2‐TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability	39
Widespread use of unconventional targeting signals in mitochondrial ribosome proteins	39
SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation	39
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	38
Role of PCIF1‐mediated 5′‐cap N6‐methyladeonsine mRNA methylation in colorectal cancer and anti‐PD‐1 immunotherapy	38
Cooperative amyloid fibre binding and disassembly by the Hsp70 disaggregase	38
Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens	38
The mitochondrial ATP synthase as an ATP consumer—a surprising therapeutic target	37
Phospholipid scramblase Xkr8 is required for developmental axon pruning via phosphatidylserine exposure	37
The Ras GTPase‐activating‐like protein IQGAP1 bridges Gasdermin D to the ESCRT system to promote IL‐1β release via exosomes	37
Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis	37
A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast	37
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	37
N4BP1 mediates RAM domain‐dependent notch signaling turnover during neocortical development	36
In vivo reduction of RAD51‐mediated homologous recombination triggers aging but impairs oncogenesis	36
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	36
High‐resolution analysis of the conformational transition of pro‐apoptotic Bak at the lipid membrane	36
Selective autophagy regulates chloroplast protein import and promotes plant stress tolerance	36
Deciphering functional tumor states at single‐cell resolution	36
Mitochondria and peroxisomes are NIXed for clearance	36
Do we still need animals? Surveying the role of animal‐free models in Alzheimer’s and Parkinson’s disease research	36
A non‐proteolytic release mechanism for HMCES‐DNA‐protein crosslinks	36
Cell envelope growth of Gram‐negative bacteria proceeds independently of cell wall synthesis	35
Helical ordering of envelope‐associated proteins and glycoproteins in respiratory syncytial virus	35
Dieter Wolf (1941–2023): a life dedicated to understanding protein quality control and the ubiquitin‐proteasome system	35
Suppression of Ca2+ signaling enhances melanoma progression	35
Disulfiram's journey from rubber vulcanization to T‐cell activation	34
A Golgi oxygen sensor controls intestinal mucin glycosylation	34
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	34
The fifth decade	34
ER exit sites take the strain	34
Classics never get old: neurotransmitters shape human cortical interneuron migration	33
AATF/Che‐1 localizes to paraspeckles and suppresses R‐loops accumulation and interferon activation in Multiple Myeloma	33
Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II	33
The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion	33
Keep the fate: how chromatin regulators safeguard embryonic stem cell identity	33
Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells	33
Nucleome programming is required for the foundation of totipotency in mammalian germline development	32
Structural mechanism of CRL4‐instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor	32
RNA is required for the integrity of multiple nuclear and cytoplasmic membrane‐less RNP granules	31
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis	31
PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid	31
Msps governs acentrosomal microtubule assembly and reactivation of quiescent neural stem cells	31
Evidence for low nanocompaction of heterochromatin in living embryonic stem cells	31
Cell line authentication: a necessity for reproducible biomedical research	31
The ion channel CALHM6 controls bacterial infection‐induced cellular cross‐talk at the immunological synapse	30
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle	30
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	30
Nicotinamide N‐methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer	30
Cellular senescence induction leads to progressive cell death via the INK4a‐RB pathway in naked mole‐rats	30
Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane	30

Inactive variants of death receptor p75 NTR reduce Alzheimer’s neuropathology by interfering with APP internalization	30
A Zn‐dependent structural transition of SOD1 modulates its ability to undergo phase separation	30
Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin	30
Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression	30
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis	29
The sun, cholesterol and Orai1 conspire in melanoma	29
SHP‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	29
HNRNPH1 regulates the neuroprotective cold‐shock protein RBM3 expression through poison exon exclusion	29
Enzyme–substrate interface targeting by imidazole‐based γ‐secretase modulators activates γ‐secretase and stabilizes its interaction withAPP	29
Reciprocal priming between receptor tyrosine kinases at recycling endosomes orchestrates cellular signalling outputs	29
A regulatory phosphorylation site on Mec1 controls chromatin occupancy of RNA polymerases during replication stress	29
Hematopoietic stem cells undergo a lymphoid to myeloid switch in early stages of emergency granulopoiesis	28
The Hda1 histone deacetylase limits divergent non‐coding transcription and restricts transcription initiation frequency	28
The SMC5/6 complex recruits the PAF1 complex to facilitate DNA double‐strand break repair in Arabidopsis	28
Discrete RNA–DNA hybrid cleavage by the EXD2 exonuclease pinpoints two rate‐limiting steps	28
Mammalian antiviral RNAi is on the move	28
An ERAD‐independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis	28
TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses	28
Barley GRIK1‐SnRK1 kinases subvert a viral virulence protein to upregulate antiviral RNAi and inhibit infection	27
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	27
Presynaptic targeting of botulinum neurotoxin type A requires a tripartitePSG‐Syt1‐SV2plasma membrane nanocluster for synaptic vesicle entry	27
Teneurin4 dimer structures reveal a calcium‐stabilized compact conformation supporting homomeric trans‐interactions	27
Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila	27
Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns	27
The MASTL/PP2A cell cycle kinase‐phosphatase module restrains PI3K‐Akt activity in an mTORC1‐dependent manner	27
Biogenesis of secretory immunoglobulin M requires intermediate non‐native disulfide bonds and engagement of the protein disulfide isomerase ERp44	27
DASH/Dam1 complex mutants stabilize ploidy in histone‐humanized yeast by weakening kinetochore‐microtubule attachments	27
Extracellular vesicles and co‐isolated endogenous retroviruses from murine cancer cells differentially affect dendritic cells	27
Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway	26
CDK11 requires a critical activator SAP30BP to regulate pre‐mRNA splicing	26
BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis	26
A tale of two Hippo pathway modules	26
Glycolysis regulates Hedgehog signalling via the plasma membrane potential	26
The CRL4 DCAF1 cullin‐RING ubiquitin ligase is activated following a switch in oligomerization state	26
PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks	26
Mechanism of transcription initiation and primer generation at the mitochondrial replication origin OriL	25
Caspase‐12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein	25
Torsin and NEP1R1‐CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid‐dependent and lipid‐independent mechanisms	25
Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3‐Lgr4 axis	25
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	25
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6	25
Distinct roles of α‐ and β‐tubulin polyglutamylation in controlling axonal transport and in neurodegeneration	25
Actin network architecture can ensure robust centering or sensitive decentering of the centrosome	24
The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading	24
ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange	24
SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation	24
Intramembrane client recognition potentiates the chaperone functions of calnexin	24
Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome	24
The CUL4B‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho‐specific DCAFs	24
Dephospho‐CoA kinase, a nuclear‐encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption	24
m 6 A modification of HSATIII lncRNAs regulates temperature‐dependent splicing	24
Single‐cell transcriptomics of LepR‐positive skeletal cells reveals heterogeneous stress‐dependent stem and progenitor pools	24
A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation	24
BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis	24
IFN‐β rescues neurodegeneration by regulating mitochondrial fission via STAT5, PGAM5, and Drp1	23
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	23
Jacob‐induced transcriptional inactivation of CREB promotes Aβ‐induced synapse loss in Alzheimer's disease	23
Cancer‐associated POT1 mutations lead to telomere elongation without induction of a DNA damage response	23
TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis	23
STIM1 and ORAI1 form a novel cold transduction mechanism in sensory and sympathetic neurons	23
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	23
The TBC1D31/praja2 complex controls primary ciliogenesis through PKA‐directed OFD1 ubiquitylation	23
CROP: a retromer‐PROPPIN complex mediating membrane fission in the endo‐lysosomal system	23
NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	23
Schwann cell precursors represent a neural crest‐like state with biased multipotency	23
Structure and functional mapping of the KRAB‐KAP1 repressor complex	23
CircPVT1 promotes ER‐positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS	22
Complete suppression of Htt fibrillization and disaggregation of Htt fibrils by a trimeric chaperone complex	22
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	22
Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein	22
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	22
ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells	22
TOC1 clock protein phosphorylation controls complex formation with NF‐YB/C to repress hypocotyl growth	22
Pioneer activity distinguishes activating from non‐activating SOX2 binding sites	22
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion	22
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	22
Cryo‐EM structure of metazoan TRAPPIII, the multi‐subunit complex that activates the GTPase Rab1	22
USP33 deubiquitinates and stabilizes HIF‐2alpha to promote hypoxia response in glioma stem cells	21
Pathogenic ACVR1R206H activation by Activin A‐induced receptor clustering and autophosphorylation	21
Novel transient cytoplasmic rings stabilize assembling bacterial flagellar motors	21
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	21
Dermal αSMA + myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production	21
Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration	21
N‐glycan processing selects ERAD‐resistant misfolded proteins for ER‐to‐lysosome‐associated degradation	21
Phospho‐regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore	20
Phosphorylation controls spatial and temporal activities of motor‐PRC1 complexes to complete mitosis	20
CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma	20
Calnexin reveals a sugar‐free taste within the lipid bilayer	20
Epigenetic inheritance is gated by naïve pluripotency and Dppa2	20
Evolutionary adaptation of the protein folding pathway for secretability	20
A novel empeROR of pancreatic malignancy	20
A sudden collapse: the disaggregation of amyloid fibres	20
A Brucella effector modulates the Arf6‐Rab8a GTPase cascade to promote intravacuolar replication	20
Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis	20
Seeing the light brings more food in the deep sea	20