EMBO Journal

Article	Citations
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR	194
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK	175
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs	175
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4 +	161
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB	148
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	139
PGE 2 ‐EP3 axis promotes brown adipose tissue formation through stabil	134
The plant noncoding transcriptome: a versatile environmental sensor	126
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	123
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	116
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and	113
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	104
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	102
Do we still need animals? Surveying the role of animal‐free models in Alzheimer’s and Parkinson’s disease research	99
TDAG51 promotes transcription factor FoxO1 activity during LPS ‐ind	97
The SMC5 /6 complex recruits the PAF1 complex to facilitate DNA	94
In vivo reduction of RAD51 ‐mediated homologous recombination triggers aging but impairs oncogenesis	93
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC	93
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	93
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1 ‐ SV2 plasma m	90
IDH2 stabilizes HIF ‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	89
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	87
CROP: a retromer‐PROPPIN complex mediating membrane fission in the endo‐lysosomal system	87
Gut colonization by Bacteroides requires translation by an EF‐G paralog lacking	87
Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity	87

Evolutionary adaptation of the protein folding pathway for secretability	86
DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion	84
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation	83
Structure of cytosine transport protein CodB provides insight into nucleobase‐cation symporter 1 mechanism	83
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona	81
Eating your mitochondria—when too much of a good thing turns bad	80
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates	79
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity	74
Interferon‐inducible phospholipids govern IFITM3 ‐dependent endosomal antiviral immunity	74
MARCH5 ‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7	73
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome	72
Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break format	72
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in	71
The Hippo pathway drives the cellular response to hydrostatic pressure	69
Strigolactones promote plant freezing tolerance by releasing the WRKY41 ‐mediated inhibition of CB	68
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	67
Ribosome biogenesis factors—from names to functions	66
A network of small RNAs regulates sporulation initiation in Clostridioides difficile	66
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease	65
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis	64
DRP1 interacts directly with BAX to induce its activation and apoptosis	64
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer	63
Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis	62
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation	62
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions	61
The CTLA ‐4 immune checkpoint protein regulates PD‐L1 : PD	60
LAMTOR1 inhibition of TRPML1‐dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function	59
Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation	59
ARF2‐PIF5 interaction controls transcriptional reprogramming in the ABS3 ‐mediated plant senescence pathway	59
Autophagy power expands: fuse those cells!	59
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma	57
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization	57
PIF7‐mediated epigenetic reprogramming promotes the transcriptional response to shade in  Arabidopsis	57
Subcellular localization of Type VI secretion system assembly in response to cell–cell contact	56
Structure and mechanism of a eukaryotic ceramide synthase complex	56
Living a longer life: unique lessons from the naked mole‐rat blood system	55
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	55
Evidence for existence of an apoptosis‐inducing BH3 ‐only protein, sayonara , in <	55
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit	53
Die another day: phytosulfokine at the molecular trade‐off between growth and defense in plants	53
Salicylic acid‐activated BIN2 phosphorylation of TGA3 promotes Arabidopsis<	51
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus	51
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy	50
c‐Maf enforces cytokine production and promotes memory‐like responses in mouse and human type 2 innate lymphoid cells	50
Stress‐dependent macromolecular crowding in the mitochondrial matrix	50
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons	50
IκB kinase‐α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage‐based anticancer therapy	49
Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response	49
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1	48
Histone retention preserves epigenetic marks during heat stress‐induced transcriptional memory in plants	48

Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement	48
Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production	48
Protein synthesis control in cancer: selectivity and therapeutic targeting	47
Extra centrosomes induce PIDD1 ‐mediated inflammation and immunosurveillance	46
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation	46
The needs of a synapse—How local organelles serve synaptic proteostasis	45
The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast	44
Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes	44
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy	44
R‐spondin signaling in the stomach: isthmal Lgr4 rules	44
Nix interacts with WIPI2 to induce mitophagy	43
LUBAC and NF‐κB trigger a nuclear response from mitochondria	43
CRIP1 suppresses BBOX1 ‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma	43
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development	43
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6	42
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity	42
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure	42
Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint	41
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	41
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	41
TFEB ‐dependent lysosome biogenesis is required for senescence	41
E‐cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities	41
Binary organization of epidermal basal domains highlights robustness to environmental exposure	40
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	40
PABP prevents the untimely decay of select mRNA populations in human cells	40
Stem cells “aclymatise” to regenerate the blood system	40
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms	40
A critical period of prehearing spontaneous Ca 2+ spiking is required for hair‐bundle maintenance in inner hair cells	40
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	39
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding	39
Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila	38
NALCN ‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	38
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle	38
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	38
Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration	38
Mammalian antiviral RNAi is on the move	38
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	37
SHP ‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	37
The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading	37
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	37
Mitochondria and peroxisomes are NIXed for clearance	37
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	36
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	35
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhanci	35
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression	35
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	35
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis	35
Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells	35
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	35
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	35
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	35
Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response	34
Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1	34
Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing	34
When yeast cells change their mind: cell cycle “Start” is reversible under starvation	34
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2	34
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA ‐mediated mitochondrial–nuclear communication	33
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HI	33
Maternal immune activation leads to defective brain blood vessels and intracerebral hemorrhages in male offspring	33
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells	33
Quorum sensing componentry opens new lines of communication	33
Fuel oxidation under the control of mitochondrial shape and dynamics	33
A sudden collapse: the disaggregation of amyloid fibres	33
Hold the fold: how delayed folding aids protein secretion	33
Targeted assembly of ectopic kinetochores to induce chromosome‐specific segmental aneuploidies	32
The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases	32
Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding	32
TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression	32
Two Hippo signaling modules orchestrate liver size and tumorigenesis	32
An alternative UPF1 isoform drives conditional remodeling of nonsense‐mediated mRNA decay	32
Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion	32
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component	32
Disulfiram bolsters T‐cell anti‐tumor immunity through direct activation of LCK‐mediated TCR signaling	32
Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel	32
Pathogenic fungi neutralize plant‐derived ROS via Srpk1 deacetylation	32
Mitotic checkpoint gene expression is tuned by codon usage bias	31
STAT1 is required to establish but not maintain interferon‐γ‐induced transcriptional memory	31
Ca 2+ signals in plant immunity	31
Cryo‐EM structure of antibacterial efflux transporter QacA from Staphylococcus aureus	31
Phosphatidic acid–regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress	31

An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation	31
AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5	31
Creativity as an antidote to research becoming too predictable	30
You can “tail” them apart: paralog‐specific functions of CRL4B ubiquitin ligases during mitosis and brain development	30
Fecal microbiota transplantation enhances cell therapy in a rat model of hypoganglionosis by SCFA ‐induced MEK1	30
microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes	30
3D imaging for driving cancer discovery	30
Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor	30
Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome	30
Sweet‐talk in the time of cholera: host mucin negotiates peace with Vibrio cholerae	30
An accessory prefrontal cortex–thalamus circuit sculpts maternal behavior in virgin female mice	30
Recycling of the actin monomer pool limits the lifetime of network turnover	30
Rewiring phospholipid biosynthesis reveals resilience to membrane perturbations and uncovers regulators of lipid homeostasis	29
LncRNA LITATS1 suppresses TGF‐β‐induced EMT and cancer cell plasticity by potentiating TβRI degradation	29
Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters	29
Retromer oligomerization drives SNX‐BAR coat assembly and membrane constriction	29
Autophagy regulates neuronal excitability by controlling cAMP /protein kinase A signaling at the synapse	29
Host cell egress of Brucella abortus requires BNIP3L ‐mediated mitophagy	29
RNase H2 degrades toxic RNA : DNA hybrids behind stalled forks to p	29
Anti‐hsa‐miR ‐59 alleviates premature senescence associated with Hutchinson‐Gilford progeria syndrome in mice	29
Spo13/ MEIKIN ensures a Two‐Division meiosis by preventing the activation of <	29
T‐cell antigen recognition: catch‐as‐catch‐can or catch‐22?	28
High‐throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory‐deprived cortical cholinergic VIP/CHAT neurons	28
Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL ‐1β release in X‐linked inhibitor of apoptosis (	28
The PAX5‐JAK2 translocation acts as dual‐hit mutation that promotes aggressive B‐cell leukemia via nuclear STAT5 activation	28
Thiol reductive stress activates the hypoxia response pathway	28
Malignant currents: sodium leak channel NALCN propels prostate cancer aggressiveness	28
Acetylation coordinates the crosstalk between carbon metabolism and ammonium assimilation in Salmonella enterica	28
Translational regulation by Hfq–Crc assemblies emerges from polymorphic ribonucleoprotein folding	28
A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans	27
Auxin‐dependent regulation of cell division rates governs root thermomorphogenesis	27
The BCL ‐2 family member BID plays a role during embryonic development in addition to its	27
Epigenetic regulation limits competence of pluripotent stem cell‐derived oocytes	26
Regulation of mitochondrial proteostasis by the proton gradient	26
Tau: a phase in the crowd	26
Condensin pinches a short negatively supercoiled DNA loop during each round of ATP usage	26
Regulation of membrane fluidity by RNF145 ‐triggered degradation of the lipid hydrolase ADIPOR2	26
Vaginal bacterium Prevotella timonensis turns protective Langerhans cells into HIV ‐1 reservoirs for v	26
Termination of STING responses is mediated via ESCRT ‐dependent degradation	26
Tau target identification reveals NSF ‐dependent effects on AMPA receptor trafficking and memory f	26
ARFs get the BioID treatment: what have we been missing?	26
The mitochondrial ATP synthase as an ATP consumer—a surprising therapeutic target	26
Nucleoporin foci are stress‐sensitive condensates dispensable for C. elegans nuclear pore assembly	26
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection	26
Making liver cancer cells go ARGh !	26
The adaptive strategies of cells in the face of CIN	26
Adaptive pathfinding by nucleokinesis during amoeboid migration	26
Promoter‐pervasive transcription causes RNA polymerase II pausing to boost	25
Phospholipid scramblase Xkr8 is required for developmental axon pruning via phosphatidylserine exposure	25
A tale of two Hippo pathway modules	25
The CUL4B ‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho	25
Suppression of Ca 2+ signaling enhances melanoma progression	25
Macrophage‐derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection	25
m6A is required for resolving progenitor identity during planarian stem cell differentiation	25
Two Hippo signaling modules orchestrate liver size and tumorigenesis	25
A systematic proximity ligation approach to studying protein‐substrate specificity identifies the substrate spectrum of the Ssh1 translocon	25
Dieter Wolf (1941–2023): a life dedicated to understanding protein quality control and the ubiquitin‐proteasome system	25
Nucleic acid–protein condensates in innate immune signaling	25
The ASC‐1 complex promotes translation initiation by scanning ribosomes	25
Role of PCIF1 ‐mediated 5′‐cap N6 ‐methyladeonsine mRNA	25
Infection and inflammation stimulate expansion of a CD74 + Paneth cell subset to regulate disease progression	25
NME6: ribonucleotide salvage sustains mitochondrial transcription	25
ER exit sites take the strain	24
Extracellular vesicles and co‐isolated endogenous retroviruses from murine cancer cells differentially affect dendritic cells	24
Cell line authentication: a necessity for reproducible biomedical research	24
Barley GRIK1‐SnRK1 kinases subvert a viral virulence protein to upregulate antiviral RNAi and inhi	24
Dermal αSMA + myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production	24
AATF /Che‐1 localizes to paraspeckles and suppresses R‐loops accumulation and interferon activation in Multiple Myeloma	24
Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular	24
TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis	24
A Zn‐dependent structural transition of SOD1 modulates its ability to undergo phase separation	24
A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation	24
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	23
The MASTL / PP2A cell cycle kinase‐phosphatase module restrains PI3K‐Akt<	23
Actin network architecture can ensure robust centering or sensitive decentering of the centrosome	23
Attenuation of SARS‐CoV ‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases	23
Mechanical forces impair antigen discrimination by reducing differences in T‐cell receptor/peptide–MHC off‐rates	23
Structure and functional mapping of the KRAB‐KAP1 repressor complex	23
Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons	23
To the bones: mapping the skeletal LEPR + pool to component cell types	23
GPNMB + Gal‐3 + hepatic parenchymal cells promote immunosuppression and hepatocellular carcinogene	23
Low membrane fluidity triggers lipid phase separation and protein segregation in living bacteria	23
Nicotinamide N‐methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer	23
Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns	23
Chromatin remodeling is required for sRNA ‐guided DNA elimination in Parame	23
Epigenetic escape of immunosurveillance by malignant cell precursors	23
Neuron‐specific translational control shift ensures proteostatic resilience during ER stress	23
High air humidity dampens salicylic acid pathway and NPR1 function to promote plant disease	22
Adaptation to high rates of chromosomal instability and aneuploidy through multiple pathways in budding yeast	22
Condensate functionalization with microtubule motors directs their nucleation in space and allows manipulating RNA localization	22
The notorious R.N.A.	22
Phosphorylation controls spatial and temporal activities of motor‐PRC1 complexes to complete mitosis	22
USP8 promotes cancer progression and extracellular vesicle‐mediated CD8 + T cell exhaustion by deubiquitinating the	22
Aberrant DNA N 6 ‐methyladenine incorporation via adenylate kinase 1 is suppressed by ADAL deaminase‐dependent 2′‐deoxynucleotide pool sanitation	22
Long noncoding RNA‐mediated epigenetic regulation of auxin‐related genes controls shade avoidance syndrome in Arabidopsis	22