EMBO Journal

Article	Citations
Autophagy in major human diseases	637
Molecular mechanisms and physiological functions of mitophagy	574
SARS ‐CoV‐2 targets neurons of 3D human brain organoids	393
Syncytia formation by SARS‐CoV‐2‐infected cells	355
m 6 A RNA methylation: from mechanisms to therapeutic potential	320
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2	313
Dynamic EMT: a multi‐tool for tumor progression	307
RNA m 6 A methylation regulates sorafenib resistance in liver cancer through FOXO 3‐mediated autophagy	259
TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells	224
Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer	224
m 6 A RNA methyltransferases METTL3/14 regulate immune responses to anti‐PD‐1 therapy	218
Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia	217
Cholesterol 25‐Hydroxylase inhibits SARS ‐CoV‐2 and other coronaviruses by depleting membrane cholesterol	202
SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs	191
Structures of the SARS ‐CoV‐2 nucleocapsid and their perspectives for drug design	191
A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast	185
Cell death pathways: intricate connections and disease implications	157
Opposing activities of IFITM proteins in SARS‐CoV‐2 infection	156
An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells	151
SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation	140
SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation	137
MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation	128
Cancer evolution: Darwin and beyond	124
Blood molecular markers associated with COVID‐19 immunopathology and multi‐organ damage	123
LRRK 2 activation controls the repair of damaged endomembranes in macrophages	116

Pore formation in regulated cell death	112
A novel approach to measure mitochondrial respiration in frozen biological samples	112
On the role of phase separation in the biogenesis of membraneless compartments	108
ATP and cancer immunosurveillance	108
Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions	107
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner	103
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction	102
The calcium transporter ANNEXIN1 mediates cold‐induced calcium signaling and freezing tolerance in plants	100
Genome‐wide cooperation of EMT transcription factor ZEB 1 with YAP and AP	100
CARD8 inflammasome activation triggers pyroptosis in human T cells	99
A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding	98
Ca 2+ signals in plant immunity	91
ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways	87
CALCOCO 1 acts with VAMP ‐associated proteins to mediate ER ‐phagy	86
RNA polymerase II speed: a key player in controlling and adapting transcriptome composition	82
Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b	82
Microglia promote glioblastoma via mTOR‐mediated immunosuppression of the tumour microenvironment	81
Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy	79
FFAT motif phosphorylation controls formation and lipid transfer function of inter‐organelle contacts	77
BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis	77
Mechanisms of site‐specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits	77
Cell softness regulates tumorigenicity and stemness of cancer cells	75
Translation of small downstream ORFs enhances translation of canonical main open reading frames	75
SARS‐CoV‐2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage	74
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation	72
Sealing holes in cellular membranes	72
Neutralization of SARS‐CoV‐2 by highly potent, hyperthermostable, and mutation‐tolerant nanobodies	71
The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking	69
Clock component OsPRR73 positively regulates rice salt tolerance by modulating OsHKT2;1 ‐mediated sodium homeostasis	69
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis	69
The multifaceted role of autophagy in cancer	68
Peering into tunneling nanotubes—The path forward	68
Highly active rubiscos discovered by systematic interrogation of natural sequence diversity	68
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses	67
Glutamine deprivation alters the origin and function of cancer cell exosomes	64
Plant immunity suppression via PHR1‐RALF‐FERONIA shapes the root microbiome to alleviate phosphate starvation	64
Fungal‐induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL‐22	64
Flavonol‐mediated stabilization of PIN efflux complexes regulates polar auxin transport	63
The extracellular vesicle generation paradox: a bacterial point of view	63
Structure of a human replisome shows the organisation and interactions of a DNA replication machine	62
BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡	62
DRP1 interacts directly with BAX to induce its activation and apoptosis	61
Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila	60
Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins	60
Roles of plant retinoblastoma protein: cell cycle and beyond	59
Syncytia formation by SARS‐CoV‐2‐infected cells	59
The multi‐scale architecture of mammalian sperm flagella and implications for ciliary motility	59
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single‐cell profiling	58
MiT/ TFE factors control ER ‐phagy via transcriptional regulation of FAM 134B	58
HOIL‐1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation	58

Paraspeckles are constructed as block copolymer micelles	57
Modulation of plant root growth by nitrogen source‐defined regulation of polar auxin transport	57
Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease	57
LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes	57
PIF1 helicase promotes break‐induced replication in mammalian cells	55
Arabidopsis shoot stem cells display dynamic transcription and DNA methylation patterns	55
Interactomes of SARS‐CoV‐2 and human coronaviruses reveal host factors potentially affecting pathogenesis	55
Best practices for the visualization, mapping, and manipulation of R‐loops	55
HDAC6 inhibition restores TDP‐43 pathology and axonal transport defects in human motor neurons with TARDBP mutations	54
The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species	54
CDK4/6 inhibitors induce replication stress to cause long‐term cell cycle withdrawal	54
Feedback regulation of heat shock factor 1 (Hsf1) activity by Hsp70‐mediated trimer unzipping and dissociation from DNA	54
Multiple pathways coordinate assembly of human mitochondrial complex IV and stabilization of respiratory supercomplexes	54
Disrupting HIV ‐1 capsid formation causes cGAS sensing of viral DNA	53
NAADP ‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca 2+ nanodomains, calcineurin and dynamin	52
Structural insights into actin filament recognition by commonly used cellular actin markers	51
Nox4 regulates InsP 3 receptor‐dependent Ca 2+ release into mitochondria to promote cell survival	51
Low membrane fluidity triggers lipid phase separation and protein segregation in living bacteria	51
NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients	50
An optimized quantitative proteomics method establishes the cell type‐resolved mouse brain secretome	50
Timeless couples G‐quadruplex detection with processing by DDX 11 helicase during DNA replication	49
Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration	49
Golgi maturation‐dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3	48
Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF	48
Cell competition in intratumoral and tumor microenvironment interactions	48
Clustering and reverse transcription of HIV‐1 genomes in nuclear niches of macrophages	48
The cold response regulator CBF1 promotes Arabidopsis hypocotyl growth at ambient temperatures	48
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress‐induced damaged mitochondrial DNA	48
Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans	47
Identification and characterization of diverse OTU deubiquitinases in bacteria	46
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection	45
Microglial MERTK eliminates phosphatidylserine‐displaying inhibitory post‐synapses	45
Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity	45
Single‐cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin‐driven circadian network	45
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair	45
Structural basis of Focal Adhesion Kinase activation on lipid membranes	45
Deciphering the regulatory landscape of fetal and adult γδ T‐cell development at single‐cell resolution	45
Molecular basis of cross‐species ACE2 interactions with SARS‐CoV‐2‐like viruses of pangolin origin	45
MSH 2 shapes the meiotic crossover landscape in relation to interhomolog polymorphism in Arabidopsis	44
Microglial PD‐1 stimulation by astrocytic PD‐L1 suppresses neuroinflammation and Alzheimer’s disease pathology	44
5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING	44
A sensory cell diversifies its output by varying Ca 2+ influx‐release coupling among active zones	44
Multilineage murine stem cells generate complex organoids to model distal lung development and disease	43
Long‐term expansion with germline potential of human primordial germ cell‐like cells in vitro	42
Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction	42
Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells	42
Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration	42
Centrosome defects cause microcephaly by activating the 53BP1‐USP28‐TP53 mitotic surveillance pathway	41
Expression of human‐specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility	41
Microtubules control nuclear shape and gene expression during early stages of hematopoietic differentiation	41
Mechanisms restraining break‐induced replication at two‐ended DNA double‐strand breaks	40
Regulation of mitochondrial proteostasis by the proton gradient	40
PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks	40
Transcription factor BES1 interacts with HSFA1 to promote heat stress resistance of plants	40
A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium	39
Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis	39
Non‐canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus	39
Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity	39
Activation of endogenous retroviruses during brain development causes an inflammatory response	39
BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis	39
Plant E3 ligases SNIPER 1 and SNIPER 2 broadly regulate the homeostasis of sensor NLR immune re	38
Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response	38
ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation	38
Identification of lectin receptors for conserved SARS‐CoV‐2 glycosylation sites	38
Centriolar distal appendages activate the centrosome‐PIDDosome‐p53 signalling axis via ANKRD26	38
SIRT 7 activates quiescent hair follicle stem cells to ensure hair growth in mice	37
Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system	37
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency	37
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis	37
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component	37
Rewired signaling network in T cells expressing the chimeric antigen receptor ( CAR )	36
Cryo‐EM structure of the CENP‐A nucleosome in complex with phosphorylated CENP‐C	36
A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase‐8	36
Transcriptional repression of NFKBIA triggers constitutive IKK‐ and proteasome‐independent p65/RelA activation in senescence	36
Munc13 activates the Munc18‐1/syntaxin‐1 complex and enables Munc18‐1 to prime SNARE assembly	36
Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway	36
Phosphoproteomic identification of ULK substrates reveals VPS15‐dependent ULK/VPS34 interplay in the regulation of autophagy	36
Nuclear cGAS: guard or prisoner?	36
m 6 A modification of HSATIII lncRNAs regulates temperature‐dependent splicing	36
LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy	35

A structural inventory of native ribosomal ABCE1‐43S pre‐initiation complexes	35
Effector‐dependent activation and oligomerization of plant NRC class helper NLRs by sensor NLR immune receptors Rpi‐amr3 and Rpi‐amr1	35
Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit	35
Open conformation of tetraspanins shapes interaction partner networks on cell membranes	35
Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates	35
Programmable C‐to‐U RNA editing using the human APOBEC 3A deaminase	35
Single‐cell transcriptomics of LepR‐positive skeletal cells reveals heterogeneous stress‐dependent stem and progenitor pools	35
Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV‐1 infection	35
Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway	35
Structural basis of nucleosome dynamics modulation by histone variants H2A.B and H2A.Z.2.2	34
HASTY , the Arabidopsis EXPORTIN5 ortholog, regulates cell‐to‐cell and vascular microRNA movement	34
ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification	34
ORP2 couples LDL‐cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange	34
Structural insights into mammalian mitochondrial translation elongation catalyzed by mt EFG 1	34
RNA localization and co‐translational interactions control RAB 13 GTP ase function and cell migration	34
Extracellular vesicles and particles impact the systemic landscape of cancer	33
A small peptide inhibits siRNA amplification in plants by mediating autophagic degradation of SGS3/RDR6 bodies	33
Ribosome biogenesis factors—from names to functions	33
Cellular stress promotes NOD1/2‐dependent inflammation via the endogenous metabolite sphingosine‐1‐phosphate	33
Self‐assembly of multi‐component mitochondrial nucleoids via phase separation	33
Selective cross‐linking of coinciding protein assemblies by in‐gel cross‐linking mass spectrometry	32
Architecture of the centriole cartwheel‐containing region revealed by cryo‐electron tomography	32
Protein structure, amino acid composition and sequence determine proteome vulnerability to oxidation‐induced damage	32
m 6 A deposition is regulated by PRMT1‐mediated arginine methylation of METTL14 in its disordered C‐terminal region	32
Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens	32
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models	32
Reproducible image handling and analysis	32
Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome	32
EGFR ‐mediated tyrosine phosphorylation of STING determines its trafficking route and cellular innate immunity functions	32
CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos	32
Netrin‐1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease features	32
Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation	31
ADP‐ribosylation of histone variant H2AX promotes base excision repair	31
Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis	31
Distinct roles of α‐ and β‐tubulin polyglutamylation in controlling axonal transport and in neurodegeneration	31
Schwann cell precursors represent a neural crest‐like state with biased multipotency	31
Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis	31
Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency	31
RNF 43 truncations trap CK 1 to drive niche‐independent self‐renewal in cancer	31
RNA is required for the integrity of multiple nuclear and cytoplasmic membrane‐less RNP granules	31
Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA	30
Adjustment of the PIF7‐HFR1 transcriptional module activity controls plant shade adaptation	30
N‐glycan processing selects ERAD‐resistant misfolded proteins for ER‐to‐lysosome‐associated degradation	30
Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding	30
N 6 ‐methyladenosine modification of lncRNA Pvt1 governs epidermal stemness	30
Photoreceptor nanotubes mediate the in vivo exchange of intracellular material	30
Dysfunctional oxidative phosphorylation shunts branched‐chain amino acid catabolism onto lipogenesis in skeletal muscle	30
Involvement of circulating factors in the transmission of paternal experiences through the germline	30
Unraveling the features of somatic transposition in the Drosophila intestine	30
Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex	29
Phosphoproteomics reveals novel modes of function and inter‐relationships among PIKKs in response to genotoxic stress	29
Protein synthesis control in cancer: selectivity and therapeutic targeting	29
A comparative analysis of the mobility of 45 proteins in the synaptic bouton	29
Cryo‐EM structure of native human uromodulin, a zona pellucida module polymer	29
Human shelterin protein POT 1 prevents severe telomere instability induced by homology‐directed DNA repair	29
Dephospho‐CoA kinase, a nuclear‐encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption	29
A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease	29
BNIP3L/NIX regulates both mitophagy and pexophagy	28
SEUSS integrates transcriptional and epigenetic control of root stem cell organizer specification	28
Metabolic shift underlies recovery in reversible infantile respiratory chain deficiency	28
Histone chaperone CAF‐1 promotes HIV‐1 latency by leading the formation of phase‐separated suppressive nuclear bodies	28
Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl‐CoA	28
ZDHHC18 negatively regulates cGAS‐mediated innate immunity through palmitoylation	28
Pathogenic ACVR1R206H activation by Activin A‐induced receptor clustering and autophosphorylation	28
Too much death can kill you: inhibiting intrinsic apoptosis to treat disease	28
Architecture of the active post‐translational Sec translocon	28
Endothelium‐derived lactate is required for pericyte function and blood–brain barrier maintenance	28
Mitochondrial translation deficiency impairs NAD + ‐mediated lysosomal acidification	28
Cryo‐EM structure of metazoan TRAPPIII, the multi‐subunit complex that activates the GTPase Rab1	28
GRASP55 regulates intra‐Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis	27
Tyr‐Asp inhibition of glyceraldehyde 3‐phosphate dehydrogenase affects plant redox metabolism	27
SNX10‐mediated LPS sensing causes intestinal barrier dysfunction via a caspase‐5‐dependent signaling cascade	27
The structure of the MICU 1‐ MICU 2 complex unveils the regulation of the mitochondrial calcium uniporter	27
IFT54 directly interacts with kinesin‐II and IFT dynein to regulate anterograde intraflagellar transport	27
Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis	27
The C‐degron pathway eliminates mislocalized proteins and products of deubiquitinating enzymes	26
Barley stripe mosaic virus γb protein disrupts chloroplast antioxidant defenses to optimize viral replication	26
Helical ordering of envelope‐associated proteins and glycoproteins in respiratory syncytial virus	26
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding	26
RNA sensing via the RIG‐I‐like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency	26
PRMT1 promotes the tumor suppressor function of p14 ARF and is indicative for pancreatic cancer prognosis	26
Dynamic properties of noise and Her6 levels are optimized by miR‐9, allowing the decoding of the Her6 oscillator	26
IFN‐β rescues neurodegeneration by regulating mitochondrial fission via STAT5, PGAM5, and Drp1	26
Nucleo‐plastidic PAP 8/ pTAC 6 couples chloroplast formation with photomorphogenesis	26
Ribosome slowdown triggers codon‐mediated mRNA decay independently of ribosome quality control	26
Rabl2 GTP hydrolysis licenses BBSome‐mediated export to fine‐tune ciliary signaling	26
m6A‐mediated alternative splicing coupled with nonsense‐mediated mRNA decay regulates SAM synthetase homeostasis	26
A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation	26
PKM2‐TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability	26
IL‐2/IL‐7‐inducible factors pioneer the path to T cell differentiation in advance of lineage‐defining factors	26
Homeostatic and pathogenic roles of GM 3 ganglioside molecular species in TLR 4 signaling in obesity	25
Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression	25
Dermal αSMA + myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production	25
Deciphering functional tumor states at single‐cell resolution	25
Cancer‐associated POT1 mutations lead to telomere elongation without induction of a DNA damage response	25