EMBO Journal

Article	Citations
A multifunctional locus controls motor neuron differentiation through short and long noncoding RNAs	1128
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells	508
SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling	181
Unbiased assessment of genome integrity and purging of adverse outcomes at the target locus upon editing of CD4+ T‐cells for the treatment of Hyper IgM1	174
A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress	161
Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis	158
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation	144
Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization	134
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization	125
Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses	114
Nascent polypeptide within the exit tunnel stabilizes the ribosome to counteract risky translation	110
Lipid metabolism: new twists to the Yin and Yang of PKM2 in cancer	109
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5	106
PKM2‐TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability	106
PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase	103
Cancer‐associated mutations in VAV1 trigger variegated signaling outputs and T‐cell lymphomagenesis	102
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease	101
The plant noncoding transcriptome: a versatile environmental sensor	101
Presynaptic targeting of botulinum neurotoxin type A requires a tripartitePSG‐Syt1‐SV2plasma membrane nanocluster for synaptic vesicle entry	99
TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses	94
Bidirectional interplay between metabolism and epigenetics in hematopoietic stem cells and leukemia	93
A sterol‐PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response	91
The SMC5/6 complex recruits the PAF1 complex to facilitate DNA double‐strand break repair in Arabidopsis	89
CROP: a retromer‐PROPPIN complex mediating membrane fission in the endo‐lysosomal system	87
Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane	82

The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6	82
In vivo reduction of RAD51‐mediated homologous recombination triggers aging but impairs oncogenesis	80
Do we still need animals? Surveying the role of animal‐free models in Alzheimer’s and Parkinson’s disease research	79
High‐resolution analysis of the conformational transition of pro‐apoptotic Bak at the lipid membrane	79
IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer	79
Single‐cell transcriptomics of LepR‐positive skeletal cells reveals heterogeneous stress‐dependent stem and progenitor pools	76
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates	75
DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion	74
CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma	74
MARCH5‐dependent NLRP3 ubiquitination is required for mitochondrial NLRP3‐NEK7 complex formation and NLRP3 inflammasome activation	72
Gut colonization by Bacteroides requires translation by an EF‐G paralog lacking GTPase activity	72
Evolutionary adaptation of the protein folding pathway for secretability	71
Ribosome biogenesis factors—from names to functions	69
EGFR signaling controls directionality of epithelial multilayer formation upon loss of cell polarity	68
An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori	66
Strigolactones promote plant freezing tolerance by releasing the WRKY41‐mediated inhibition of CBF/DREB1 expression	66
Cristae formation is a mechanical buckling event controlled by the inner mitochondrial membrane lipidome	65
Eating your mitochondria—when too much of a good thing turns bad	63
A network of small RNAs regulates sporulation initiation in Clostridioides difficile	62
RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona	62
Single‐cell transcriptomics stratifies organoid models of metabolic dysfunction‐associated steatotic liver disease	62
cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation	60
The birth of a giant: evolutionary insights into the origin of auxin responses in plants	58
Sir3 heterochromatin protein promotes non‐homologous end joining by direct inhibition of Sae2	58
Interferon‐inducible phospholipids govern IFITM3‐dependent endosomal antiviral immunity	58
The Hippo pathway drives the cellular response to hydrostatic pressure	58
Characterization of the REC114‐MEI4‐IHO1 complex regulating meiotic DNA double‐strand break formation	57
Regulated splicing of large exons is linked to phase‐separation of vertebrate transcription factors	57
Structure of cytosine transport protein CodB provides insight into nucleobase‐cation symporter 1 mechanism	57
Dynamic EMT: a multi‐tool for tumor progression	57
Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity	56
The glycine arginine‐rich domain of the RNA‐binding protein nucleolin regulates its subcellular localization	56
ARF2‐PIF5 interaction controls transcriptional reprogramming in the ABS3‐mediated plant senescence pathway	55
Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis	55
DRP1 interacts directly with BAX to induce its activation and apoptosis	55
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma	55
Modified Messengers: flatworm stem cells and regeneration are guarded by RNA methylation	54
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer	53
Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans	53
Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis	53
The CTLA‐4 immune checkpoint protein regulates PD‐L1:PD‐1 interaction via transendocytosis of its ligand CD80	53
Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b‐mediated chromatin demethylation	52
Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization	51
Autophagy power expands: fuse those cells!	50
LAMTOR1 inhibition of TRPML1‐dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function	49
Assembly and function of the amyloid‐like translational repressor Rim4 is coupled with nutrient conditions	49
Subcellular localization of Type VI secretion system assembly in response to cell–cell contact	48
Salicylic acid‐activated BIN2 phosphorylation of TGA3 promotes Arabidopsis PR gene expression and disease resistance	48
c‐Maf enforces cytokine production and promotes memory‐like responses in mouse and human type 2 innate lymphoid cells	48
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit	47

Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response	46
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy	46
Living a longer life: unique lessons from the naked mole‐rat blood system	46
Die another day: phytosulfokine at the molecular trade‐off between growth and defense in plants	46
C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation	45
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A	44
IκB kinase‐α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage‐based anticancer therapy	44
Histone retention preserves epigenetic marks during heat stress‐induced transcriptional memory in plants	44
Circadian time‐ and sleep‐dependent modulation of cortical parvalbumin‐positive inhibitory neurons	42
Immune surveillance of brain metastatic cancer cells is mediated by IFITM1	42
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus	42
Evidence for existence of an apoptosis‐inducing BH3‐only protein, sayonara, in Drosophila	42
PIF7‐mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis	42
Stress‐dependent macromolecular crowding in the mitochondrial matrix	42
Cancer evolution: Darwin and beyond	41
BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response	40
Protein synthesis control in cancer: selectivity and therapeutic targeting	40
Structure and mechanism of a eukaryotic ceramide synthase complex	40
DNA asymmetry promotes SUMO modification of the single‐stranded DNA‐binding protein RPA	39
Coronaviral ORF6 protein mediates inter‐organelle contacts and modulates host cell lipid flux for virus production	39
Extracellular vesicles from Zika virus‐infected cells display viral E protein that binds ZIKV‐neutralizing antibodies to prevent infection enhancement	39
Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway	39
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation	39
Endosome maturation links PI3Kα signaling to lysosome repopulation during basal autophagy	38
Seeing eye to eye: photoreceptors employ nanotube‐like connections for material transfer	38
Plant YTHDF proteins are direct effectors of antiviral immunity against an N6‐methyladenosine‐containing RNA virus	38
R‐spondin signaling in the stomach: isthmal Lgr4 rules	38
Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes	37
TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure	37
Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets	37
Reply to “An alternative miRISC targets a cancer‐associated coding sequence mutation in FOXL2”	37
Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development	37
DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity	37
TFEB‐dependent lysosome biogenesis is required for senescence	37
The needs of a synapse—How local organelles serve synaptic proteostasis	37
The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast	37
CRIP1 suppresses BBOX1‐mediated carnitine metabolism to promote stemness in hepatocellular carcinoma	37
LUBAC and NF‐κB trigger a nuclear response from mitochondria	36
The cellular modifier MOAG‐4/SERF drives amyloid formation through charge complementation	36
Nix interacts with WIPI2 to induce mitophagy	36
PABP prevents the untimely decay of select mRNA populations in human cells	35
Multi‐modal adaptor‐clathrin contacts drive coated vesicle assembly	35
Extra centrosomes induce PIDD1‐mediated inflammation and immunosurveillance	35
Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates	35
Stem cells “aclymatise” to regenerate the blood system	34
E‐cadherin mediates apical membrane initiation site localisation duringde novopolarisation of epithelial cavities	34
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment	34
A critical period of prehearing spontaneous Ca2+ spiking is required for hair‐bundle maintenance in inner hair cells	34
The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis	34
Binary organization of epidermal basal domains highlights robustness to environmental exposure	34
Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms	33
Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint	33
Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration	33
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding	33
Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS	33
The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading	33
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	33
Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells	33
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis	32
NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness	32
A lipid hydrolase and a ubiquitin ligase play hide‐and‐seek in the ER membrane	32
The cell cycle and cell size influence the rates of global cellular translation and transcription in fission yeast	32
Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila	32
Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies	32
ZAKβ is activated by cellular compression and mediates contraction‐induced MAP kinase signaling in skeletal muscle	32
The CRL4 DCAF1 cullin‐RING ubiquitin ligase is activated following a switch in oligomerization state	32
Deciphering functional tumor states at single‐cell resolution	32
Mammalian antiviral RNAi is on the move	32
SHP‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription	32
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging	32
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis	32
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination	32
Msps governs acentrosomal microtubule assembly and reactivation of quiescent neural stem cells	32
The eukaryotic translation initiation factor eIF4E reprograms alternative splicing	31
A salt stress‐activated GSO1‐SOS2‐SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion	31
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models	31
Acetate is a beneficial nutrient for E. coli at low glycolytic flux	31
Mitochondria and peroxisomes are NIXed for clearance	31
Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1	31
A sudden collapse: the disaggregation of amyloid fibres	30

Hypoxia promotes osteogenesis by facilitating acetyl‐CoA‐mediated mitochondrial–nuclear communication	30
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression	30
Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing	30
Quorum sensing componentry opens new lines of communication	30
Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response	30
When yeast cells change their mind: cell cycle “Start” is reversible under starvation	30
Some viruses need to phase‐separate to replicate	30
Hold the fold: how delayed folding aids protein secretion	29
The ribosomal chaperone NACA recruits PHD2 to cotranslationally modify HIF‐α	29
Microglial PD‐1 stimulation by astrocytic PD‐L1 suppresses neuroinflammation and Alzheimer’s disease pathology	29
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells	29
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses	29
An alternative UPF1 isoform drives conditional remodeling of nonsense‐mediated mRNA decay	28
Piwi–piRNA complexes induce stepwise changes in nuclear architecture at target loci	28
Disulfiram bolsters T‐cell anti‐tumor immunity through direct activation of LCK‐mediated TCR signaling	28
Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines	28
Fluc‐EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease	28
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component	28
The cryo‐EM structure of the CENP‐A nucleosome in complex with ggKNL2	28