Biochemical Journal

Article	Citations
Respiratory epithelial cell types, states and fates in the era of single-cell RNA-sequencing	871
Michael D. Waterfield	209
A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity	189
Identification of inhibitors of human ChaC1, a cytoplasmic glutathione degrading enzyme through high throughput screens in yeast	105
Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor	103
Development of an OTUD1 ubiquitin variant inhibitor	68
Cas11 augments Cascade functions in type I-E CRISPR system but is redundant for gene silencing and plasmid interference	64
Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method	58
Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane	57
GlmS mediated knock-down of a phospholipase expedite alternate pathway to generate phosphocholine required for phosphatidylcholine synthesis in Plasmodium falciparum	54
Combinatorial approaches for mitigating resistance to KRAS-targeted therapies	53
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells	53
Aurora A binds to the transactivation domain of c-Myc and recognizes the phosphorylated N-terminal degron motif	52
In search for structural targets for engineering d-amino acid transaminase: modulation of pH optimum and substrate specificity	51
A guide to ERK dynamics, part 2: downstream decoding	50
Programmed cell death: the pathways to severe COVID-19?	50
A curated list of targeted optimized promiscuous ketoreductases (TOP-K)	48
Improved furfural tolerance in Escherichia coli mediated by heterologous NADH-dependent benzyl alcohol dehydrogenases	48
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses	47
Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation	47
Calcium signalling components underlying NPK homeostasis: potential avenues for exploration	44
Serine acetyltransferase from Neisseria gonorrhoeae; structural and biochemical basis of inhibition	44
Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel–Lindau syndrome	42
BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia	42
CORM-3 induces DNA damage through Ru(II) binding to DNA	40

Expression of neuronal NO synthase α- and β-isoforms in skeletal muscle of mice	40
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications	38
TOR complex 2 is a master regulator of plasma membrane homeostasis	38
The C-terminal structure of the N6-methyladenosine deaminase YerA and its role in deamination	38
Protein kinase A and local signaling in cancer	36
The atypical thioredoxin ‘Alr2205’, a newly identified partner of the typical 2-Cys-Peroxiredoxin, safeguards the cyanobacterium Anabaena from oxidative stress	36
Identification and characterization of the Doublesex gene and its mRNA isoforms in the brine shrimp Artemia franciscana	35
Cryo-EM structure of human MG53 homodimer	34
Expression of Concern: Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway	33
The role of mitochondrial RNA association for mitochondrial homeostasis in neurons	33
Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues	32
RhoGAP6 interacts with COPI to regulate protein transport	32
Correction: Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity.	29
Towards ‘end-to-end’ analysis and understanding of biological timecourse data	29
Sequence variation in the active site of mobile colistin resistance proteins is evolutionarily accommodated through inter-domain interactions	29
Interplay of constipation, intestinal barrier dysfunction and fungal exposome in aetiopathogenesis of Parkinson’s disease: hypothesis with supportive data	28
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator	28
Lead induces the upregulation of protein arginine methyltransferase 5 possibly by its promoter demethylation	28
Interactions between insulin and exercise	28
Proteotoxic stresses stimulate dissociation of UBL4A from the tail-anchored protein recognition complex	28
FoxO transcription factors in mitochondrial homeostasis	25
Characterisation of an influenza B virus-derived peptide presented by HLA-B*18:01	25
Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?	25
Correction: The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h	24
Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling	24
The uncharacterized protein ZNF200 interacts with PRMT3 and aids its stability and nuclear translocation	24
Thermodynamic analysis of Zα domain-nucleic acid interactions	23
GLUT4 On the move	23
Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway	23
Conservation of endo-glucanase 16 (EG16) activity across highly divergent plant lineages	22
Structure and function of MDM2 and MDM4 in health and disease	22
Alphabetti kinase Spaghetti: the complex roles of IKKα and β in the canonical NF-κB pathway	22
Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis	22
Insight into the function of active site residues in the catalytic mechanism of human ferrochelatase	21
Retraction: Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin	21
Gibberellin-biosynthetic ent-kaurene synthases in higher plants do not require their non-catalytic domains for the catalysis	21
Retraction: Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure	21
NAD-catabolizing ectoenzymes of Schistosoma mansoni	21
Ubiquitin E3 ligases in the plant Arg/N-degron pathway	20
Yop1 stability and membrane curvature generation propensity are controlled by its oligomerisation interface	20
Adapting to change: resolving the dynamic and dual roles of NCK1 and NCK2	20
Elevated CO2 alters photosynthesis, growth and susceptibility to powdery mildew of oak seedlings	19
The structure and function of modular Escherichia coli O157:H7 bacteriophage FTBEc1 endolysin, LysT84: defining a new endolysin catalytic subfamily	19
Targeting bacterial degradation machinery as an antibacterial strategy	19
IFIT3 (interferon induced protein with tetratricopeptide repeats 3) modulates STAT1 expression in small extracellular vesicles	18
The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors	18
Exopolysaccharide is detrimental for the symbiotic performance of Sinorhizobium fredii HH103 mutants with a truncated lipopolysaccharide core	18
Functional insights into Mycobacterium tuberculosis DevR-dependent transcriptional machinery utilizing Escherichia coli	18
Leukotriene B4 receptor 1 does not mediate disease progression in a mouse model of liver fibrosis	18
EZH2 promotes chemoresistance in colorectal cancer by inhibiting autophagy through NRP1 suppression	17

From the Belousov–Zhabotinsky reaction to biochemical clocks, traveling waves and cell cycle regulation	17
Activity-based probes for dynamic characterisation of polysaccharide-degrading enzymes	17
Distinct interactors define the p63 transcriptional signature in epithelial development or cancer	17
Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2	17
Comparison of Classical P81 and SVI-P Cation-Exchange Papers in Radiometric Protein Kinase Assays	16
Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system	16
Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlierAtITPK4	15
LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin	15
Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes	15
Abscisic acid triggers vitamin E accumulation by transient transcript activation of VTE5 and VTE6 in sweet cherry fruits	15
PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target	15
Activation and manipulation of inflammasomes and pyroptosis during bacterial infections	15
Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity	15
Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery	15
Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth	14
Proteomic mapping and optogenetic manipulation of membrane contact sites	14
DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability	14
TAT–RHIM: a more complex issue than expected	14
Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity	14
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding	14
Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5	14
Sequence rules for a long SPOP-binding degron required for protein ubiquitylation	14
Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway	14
Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain	14
Per aspera ad chaos: a personal journey to the wonderland of intrinsic disorder	14
Kinases leave their mark on caspase substrates	14
Dynamic interchange of local residue–residue interactions in the largely extended single alpha-helix in Drebrin	14
Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity	14
Correction: NAD+-consuming enzymes in immune defense against viral infection	13
A Plasmodium falciparum ubiquitin-specific protease (PfUSP) is essential for parasite survival and its disruption enhances artemisinin efficacy	13
PHF1 compartmentalizes PRC2 via phase separation	13
Genetic modulation of CWD prion propagation in cervid PrP Drosophila	13
Flavin oxidation state impacts on nitrofuran antibiotic binding orientation in nitroreductases	13
Macropinocytosis: mechanisms and regulation	13
The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms	13
Synthesis, biochemical characterization and in silico investigation of 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid derivatives: dual action mode inhibitors of urease and virulent bacterial	12
Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases	12
Key structural role of a conserved cis-proline revealed by the P285S variant of soybean serine hydroxymethyltransferase 8	12
The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes	12
The impact of cell states on heterochromatin dynamics	12
The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase	12
The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?	11
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing	11
The role of the γ subunit in the photosystem of the lowest-energy phototrophs	11
Mechanistic diversity in MHC class I antigen recognition	11
The C-terminal sequences of Bcl-2 family proteins mediate interactions that regulate cell death	11
The C-terminal region of phytoene synthase is a key element to control carotenoid biosynthesis in the haloarchaeon Haloferax volcanii	11
Genome damage accumulated in seed ageing leads to plant genome instability and growth inhibition	11
Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2	11
Plant adaptation to climate change	11
Beyond protein modification: the rise of non-canonical ADP-ribosylation	11
Overexpression of phospholipid: diacylglycerol acyltransferase in Brassica napus results in changes in lipid metabolism and oil accumulation	11
Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation	10
The bacterial transcription terminator, Rho, functions as an RNA:DNA hybrid (RDH) helicase in vivo	10
Characterization of ADAT2/3 molecules in Trypanosoma cruzi and regulation of mucin gene expression by tRNA editing	10
The many ways that nature has exploited the unusual structural and chemical properties of phosphohistidine for use in proteins	10
Development of a colorimetric assay for the detection of SARS-CoV-2 3CLpro activity	10
ISGylation-independent protection of cell growth by USP18 following interferon stimulation	10
Common and unique features of glycosylation and glycosyltransferases in African trypanosomes	10
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965	10
Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma	10
Decoding the consecutive lysosomal degradation of 3-O-sulfate containing heparan sulfate by Arylsulfatase G (ARSG)	9
Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs	9
Pyroptotic executioner pore-forming protein gasdermin D forms oligomeric assembly and exhibits amyloid-like attributes that could contribute for its pore-forming function	9
Molecular mechanisms of mammalian autophagy	9
Revamped Role for Approved Drug: Integrative Computational and Biophysical Analysis of Saquinavir's PAD4 Inhibition for Rheumatoid Arthritis	9
Site IQ in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions	9
RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers	9
Entangling roles of cholesterol-dependent interaction and cholesterol-mediated lipid phase heterogeneity in regulating listeriolysin O pore-formation	9
LASP-1 interacts with ErbB2 in ovarian cancer cells	9
The role of phosphorylation in calmodulin-mediated gating of human AQP0	9
Correction: Proteasome and thiol involvement in quality control of glycosylphosphatidylinositol anchor addition	9
The NFkB activation domain is 14-amino-acid-long variant of the 9aaTAD	9
Shaping mitochondria through fed–fast and circadian cycles	9
The monodomain Kunitz protein EgKU-7 from the dog tapeworm Echinococcus granulosus is a high-affinity trypsin inhibitor with two interaction sites	9
α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif	9
TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells	9
The role of eIF2 phosphorylation in cell and organismal physiology: new roles for well-known actors	9
The roles of epigenetics in cancer progression and metastasis	9
Regulation of Rubisco activity by interaction with chloroplast metabolites	9

Skin in the game: pannexin channels in healthy and cancerous skin	8
Excess Wnt in neurological disease	8
Excess iodide-induced reactive oxygen species elicit iodide efflux via β-tubulin-associated ClC-3 in thyrocytes	8
Into the fold: advances in understanding aPKC membrane dynamics	8
Chilling or chemical induction of dormancy release in blackcurrant (Ribes nigrum) buds is associated with characteristic shifts in metabolite profiles	8
Structure of the major oxidative damage 7,8-dihydro-8-oxoguanine presented into a catalytically competent DNA glycosylase	8
Root system growth and development responses to elevated CO2: underlying signalling mechanisms and role in improving plant CO2 capture and soil C storage	8
Biochemical investigations of polyphenol degradation enzymes in the phototrophic bacterium Rubrivivax gelatinosus	8
Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential	8
Colonic ketogenesis, a microbiota-regulated process, contributes to blood ketones and protects against colitis in mice	8
Loss of peroxiredoxin 6 alters lipid composition and distribution resulting in increased sensitivity to ferroptosis	8
Structural and molecular bases to IRE1 activity modulation	8
A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11	8
Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2α phosphorylation	8
Vitamin K3 inhibits FtsZ assembly, disrupts the Z-ring in Streptococcus pneumoniae and displays anti-pneumococcal activity	8
Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia	8
The genetic and molecular basis of a connexin-linked skin disease	7
Multifaceted roles of Epac signaling in renal functions	7
Systems approaches to investigate the role of NF-κB signaling in aging	7
Role of LRRK2 in axonal transport and Parkinson’s disease	7
A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes	7
Quantitative metabolic fluxes regulated by trans-omic networks	7
Protein targeting by the itaconate family in immunity and inflammation	7
Dynamic interactions between SPX proteins, the ubiquitination machinery, and signalling molecules for stress adaptation at a whole-plant level	7
Activating mutations drive human MEK1 kinase using a gear-shifting mechanism	7
Telomerase RNA evolution: a journey from plant telomeres to broader eukaryotic diversity	7
Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity	7
The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress	7
Chaetocin disrupts the SUV39H1–HP1 interaction independent of SUV39H1 methyltransferase activity	7
Ferroptosis in plants: regulation of lipid peroxidation and redox status	7
Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate	7
Correction: Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex	7
A prescription for engineering PFAS biodegradation	7
N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum	7
Correction: Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366	7
Long-range electron proton coupling in respiratory complex I — insights from molecular simulations of the quinone chamber and antiporter-like subunits	7
Intelligent host engineering for metabolic flux optimisation in biotechnology	7
NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes	7
No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors	7
Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly	7
Conserved L464 in p97 D1–D2 linker is critical for p97 cofactor regulated ATPase activity	7
Cryo-EM structure of the monomeric Rhodobacter sphaeroides RC–LH1 core complex at 2.5 Å	6
Regulation of the mitotic chromosome folding machines	6
Exploring the dynamics and interactions of the N-myc transactivation domain through solution nuclear magnetic resonance spectroscopy	6
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death	6
UBE2A/B is the trans-acting factor mediating mechanotransduction and contact inhibition	6
Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach	6
E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease	6
The function of BK channels extracted and purified within SMALPs	6
How do cells stiffen?	6
Understanding interleukin 11 as a disease gene and therapeutic target	6
ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding	6
Development of circadian rhythms in mammalian systems	6
From the ‘black box' to ‘domino effect' mechanism: what have we learned from the structures of respiratory complex I	6
Investigating the differential structural organization and gene expression regulatory networks of lamin A Ig fold domain mutants of muscular dystrophy	6
Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity	6
AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue	6
Mitophagy in yeast: known unknowns and unknown unknowns	6
Sperm induce a secondary increase in ATP levels in mouse eggs that is independent of Ca2+ oscillations	6
Metal-sensing properties of the disordered loop from the Arabidopsis metal transceptor IRT1	6
Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyte	6
Multiple transactivation domains of EZH2 bind to the TAZ2 domain of p300 and stimulate the acetyltransferase function of p300	6
LRRK2-mediated mitochondrial dysfunction in Parkinson’s disease	6
Paraquat resistance mutations have differential effects on plant fitness in two rice cultivars	6
Correction: Bioinformatic and experimental evidence for suicidal and catalytic plant THI4s	6
Trypanosomatid histones: the building blocks of the epigenetic code of highly divergent eukaryotes	6
Genotoxic effects of the major alkylation damage N7-methylguanine and methyl formamidopyrimidine	5
Inherited disease-linked arginine76/75 mutants in Cx50 and Cx45 showed impaired homotypic and heterotypic gap junction function, but not Cx43	5
Sulfoquinovosyl diacylglycerol is required for dimerisation of the Rhodobacter sphaeroides reaction centre-light harvesting 1 core complex	5
How many kinases are druggable? A review of our current understanding	5
Retraction: Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155	5
Evolution of the conformational ensemble and allosteric networks of apoptotic caspases in chordates	5
Inhibition of RIPK1 or RIPK3 kinase activity post ischemia-reperfusion reduces the development of chronic kidney injury	5
An efficient triose phosphate synthesis and distribution in wheat provides tolerance to higher field temperatures	5
Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism?	5
A guide to ERK dynamics, part 1: mechanisms and models	5
Short- and long-term warming events on photosynthetic physiology, growth, and yields of field grown crops	5
Gα12 and Gα13 proteins are required for transforming growth factor-β-induced myofibroblast differentiation	5
NAD+-consuming enzymes in immune defense against viral infection	5
Comparative analysis of canine and human HtrA2 to delineate its role in apoptosis and cancer	5
Thermoregulated transcriptomics: the molecular basis and biological significance of temperature-dependent alternative splicing	5
Hydrogen sulfide in ageing, longevity and disease	5
Phosphatidylserine binding directly regulates TIM-3 function	5
Structural insights into allosteric inhibition of HRI kinase by heme binding via HDX-MS	5
Integration of machine learning with computational structural biology of plants	4
Lactate cross-talk in host–pathogen interactions	4
Binding partners regulate unfolding of myosin VI to activate the molecular motor	4
Pharmaco-nutraceutical improvement of the response to obeticholic acid with omega-3 polyunsaturated fatty acids	4
The continued evolution of the L2 cephalosporinase in Stenotrophomonas maltophilia: a key driver of beta-lactam resistance	4
Interaction of the periplasmic chaperone SurA with the inner membrane protein secretion (SEC) machinery	4
Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes	4
Proteomic analysis reveals inhibition of mevalonate and Glycolysis pathways in hepatocytes by 27-hydroxycholesterol	4
GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration	4
Impact of climate perturbations on seeds and seed quality for global agriculture	4
Higher expression of proline dehydrogenase altered mitochondrial function and increased Trypanosoma cruzi differentiation in vitro and in the insect vector	4