Biochemical Journal

Article	Citations
Michael D. Waterfield	133
Identification of inhibitors of human ChaC1, a cytoplasmic glutathione degrading enzyme through high throughput screens in yeast	88
Development of an OTUD1 ubiquitin variant inhibitor	86
Cas11 augments Cascade functions in type I-E CRISPR system but is redundant for gene silencing and plasmid interference	85
Mutational insights into human kynurenine aminotransferase 1: modulation of transamination and β-elimination activities across diverse substrates	83
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells	78
Aurora A binds to the transactivation domain of c-Myc and recognizes the phosphorylated N-terminal degron motif	66
A curated list of targeted optimized promiscuous ketoreductases (TOP-K)	61
A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity	57
Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor	55
In search for structural targets for engineering d-amino acid transaminase: modulation of pH optimum and substrate specificity	50
Combinatorial approaches for mitigating resistance to KRAS-targeted therapies	42
A guide to ERK dynamics, part 2: downstream decoding	40
Respiratory epithelial cell types, states and fates in the era of single-cell RNA-sequencing	39
Cold exposure remodels bile acid metabolism in a mouse strain- and tissue-specific manner	38
Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method	37
Modulating backbone flexibility in hydroxamate siderophores for improved iron chelation and peptide nucleic acid delivery into bacteria	36
Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane	34
Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel–Lindau syndrome	34
Rules of the road: how to turn off kinesin motors	34
Expression of neuronal NO synthase α- and β-isoforms in skeletal muscle of mice	33
CORM-3 induces DNA damage through Ru(II) binding to DNA	28
BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia	28
The atypical thioredoxin ‘Alr2205’, a newly identified partner of the typical 2-Cys-Peroxiredoxin, safeguards the cyanobacterium Anabaena from oxidative stress	28
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses	28

Identification and functional characterization of two CXCL17 paralogs from zebrafish	26
Calcium signalling components underlying NPK homeostasis: potential avenues for exploration	26
Characterisation of an influenza B virus-derived peptide presented by HLA-B*18:01	25
TOR complex 2 is a master regulator of plasma membrane homeostasis	25
De novo talin-1 variant L353F connects multifaceted clinical symptoms to alterations in talin-1 function	25
The C-terminal structure of the N6-methyladenosine deaminase YerA and its role in deamination	25
Cryo-EM structure of human MG53 homodimer	24
Sequence variation in the active site of mobile colistin resistance proteins is evolutionarily accommodated through inter-domain interactions	24
The role of mitochondrial RNA association for mitochondrial homeostasis in neurons	23
RhoGAP6 interacts with COPI to regulate protein transport	23
Proteotoxic stresses stimulate dissociation of UBL4A from the tail-anchored protein recognition complex	23
Correction: Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity.	22
Lead induces the upregulation of protein arginine methyltransferase 5 possibly by its promoter demethylation	22
Expression of Concern: Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway	22
Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues	21
Oligomeric assemblies of plant biotin carboxylase revealed by cryo-EM and cross-linking	20
Structural characterization of OsPDIL2-3, a rice protein disulfide isomerase involved in prolamin accumulation	20
The role of linker length and composition in actin binding and bundling by palladin	20
Interplay of constipation, intestinal barrier dysfunction and fungal exposome in aetiopathogenesis of Parkinson’s disease: hypothesis with supportive data	20
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator	19
Clostridium beijerinckii displays a soluble [FeFe]-hydrogenase/formate dehydrogenase enzyme complex that links H2 and CO2 metabolism	19
Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?	19
Identification and characterization of the Doublesex gene and its mRNA isoforms in the brine shrimp Artemia franciscana	19
Protein kinase A and local signaling in cancer	19
Towards ‘end-to-end’ analysis and understanding of biological timecourse data	19
Alphabetti kinase Spaghetti: the complex roles of IKKα and β in the canonical NF-κB pathway	18
Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway	18
Correction: The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h	18
Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis	18
The uncharacterized protein ZNF200 interacts with PRMT3 and aids its stability and nuclear translocation	18
Use of hydrogen deuterium exchange mass spectrometry in tandem with modern structural biology	17
Gibberellin-biosynthetic ent-kaurene synthases in higher plants do not require their non-catalytic domains for the catalysis	17
Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling	17
NAD-catabolizing ectoenzymes of Schistosoma mansoni	17
Gut reactions and gut instincts: regulation of intestinal homeostasis by receptor guanylyl cyclase C (GC-C)	16
Retraction: Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure	16
Serendipitous discovery of an allosteric inhibitor binding groove in the proline biosynthetic enzyme pyrroline-5-carboxylate reductase 1	16
Functional analysis and transcriptional profiling of non-coding RNAs in yeast	16
Adapting to change: resolving the dynamic and dual roles of NCK1 and NCK2	16
Thermodynamic analysis of Zα domain-nucleic acid interactions	16
Structure and function of MDM2 and MDM4 in health and disease	16
Retraction: Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin	16
Targeting bacterial degradation machinery as an antibacterial strategy	15
Ubiquitin E3 ligases in the plant Arg/N-degron pathway	15
Yop1 stability and membrane curvature generation propensity are controlled by its oligomerisation interface	15
Combination amino acids and glucose effects on insulin and GLP-1 secretion	15
An expanded role for single-cell chemical genomics profiling in drug discovery	15
Leukotriene B4 receptor 1 does not mediate disease progression in a mouse model of liver fibrosis	15
Proteostasis of immune checkpoint receptors	15
Elevated CO2 alters photosynthesis, growth and susceptibility to powdery mildew of oak seedlings	15

The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors	14
Comparison of Classical P81 and SVI-P Cation-Exchange Papers in Radiometric Protein Kinase Assays	14
Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2	14
Exopolysaccharide is detrimental for the symbiotic performance of Sinorhizobium fredii HH103 mutants with a truncated lipopolysaccharide core	14
Itaconate utilisation by the human pathogen Pseudomonas aeruginosa requires uptake via the IctPQM TRAP transporter	14
Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery	13
Peeking behind the carbocation: identification of (alternative) catalytic bases in the class II active site of conifer resin acid diterpene synthases	13
Activity-based probes for dynamic characterisation of polysaccharide-degrading enzymes	13
Towards broad-spectrum antiviral drugs: inhibition of transmembrane serine proteases	13
EZH2 promotes chemoresistance in colorectal cancer by inhibiting autophagy through NRP1 suppression	13
Editorial Note: Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling	13
Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth	13
Distinct interactors define the p63 transcriptional signature in epithelial development or cancer	13
The peculiar properties of mitochondrial carriers of the SLC25 family	12
Abscisic acid triggers vitamin E accumulation by transient transcript activation of VTE5 and VTE6 in sweet cherry fruits	12
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding	12
A metabolite extracted from Escherichia coli suppresses tau aggregation	12
Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlierAtITPK4	12
Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes	12
Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity	12
Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5	11
Sequence rules for a long SPOP-binding degron required for protein ubiquitylation	11
PHF1 compartmentalizes PRC2 via phase separation	11
Proteomic mapping and optogenetic manipulation of membrane contact sites	11
Genetic modulation of CWD prion propagation in cervid PrP Drosophila	11
Penetrant PKCβ mutation in ATLL displays a mixed gain-of-function	11
Docking in the Abies grandis abietaenol synthase to investigate the mechanism underlying conifer resin acid diterpene synthase evolution	11
Dynamic interchange of local residue–residue interactions in the largely extended single alpha-helix in Drebrin	11
Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain	11
Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity	10
Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity	10
Synthesis, biochemical characterization and in silico investigation of 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid derivatives: dual action mode inhibitors of urease and virulent bacterial	10
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing	10
Genome damage accumulated in seed ageing leads to plant genome instability and growth inhibition	10
A Plasmodium falciparum ubiquitin-specific protease (PfUSP) is essential for parasite survival and its disruption enhances artemisinin efficacy	10
Macropinocytosis: mechanisms and regulation	10
DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability	10
The C-terminal region of phytoene synthase is a key element to control carotenoid biosynthesis in the haloarchaeon Haloferax volcanii	10
The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase	10
Expression and characterization of an endo-β-1,6-galactanase from Arabidopsis thaliana	10
The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms	10
The role of the γ subunit in the photosystem of the lowest-energy phototrophs	10
The impact of cell states on heterochromatin dynamics	10
The monodomain Kunitz protein EgKU-7 from the dog tapeworm Echinococcus granulosus is a high-affinity trypsin inhibitor with two interaction sites	9
Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation	9
Key structural role of a conserved cis-proline revealed by the P285S variant of soybean serine hydroxymethyltransferase 8	9
The bacterial transcription terminator, Rho, functions as an RNA:DNA hybrid (RDH) helicase in vivo	9
The C-terminal sequences of Bcl-2 family proteins mediate interactions that regulate cell death	9
Entangling roles of cholesterol-dependent interaction and cholesterol-mediated lipid phase heterogeneity in regulating listeriolysin O pore-formation	9
The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?	9
AmyloGram reveals amyloidogenic potential in stroke thrombus proteomes	9
Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2	9
Molecular foundations of collagen triple helical assembly: the central role of prolyl-4-hydroxylation	9
Phosphorus-specific, liquid chromatography inductively coupled plasma mass spectrometry for analysis of inositol phosphate and inositol pyrophosphate metabolism	9
Inducing TRIB2-targeted protein degradation to reverse chemoresistance in acute myeloid leukaemia	9
The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes	9
Modulation of Nur77–DNA interactions by the glucocorticoid receptor	9
Plant adaptation to climate change	9
Modulation of Ube2R1 activity by a nanobody that binds near its N-terminus	9
Revamped Role for Approved Drug: Integrative Computational and Biophysical Analysis of Saquinavir's PAD4 Inhibition for Rheumatoid Arthritis	8
Shaping mitochondria through fed–fast and circadian cycles	8
And… cut! – how conformational regulation of CRISPR-Cas effectors directs nuclease activity	8
The role of phosphorylation in calmodulin-mediated gating of human AQP0	8
Site IQ in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions	8
Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma	8
Common and unique features of glycosylation and glycosyltransferases in African trypanosomes	8
ISGylation-independent protection of cell growth by USP18 following interferon stimulation	8
RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers	8
Structure of the major oxidative damage 7,8-dihydro-8-oxoguanine presented into a catalytically competent DNA glycosylase	8
The NFkB activation domain is 14-amino-acid-long variant of the 9aaTAD	8
Structural basis for inhibition of SpyCas9 by the anti-CRISPR protein AcrIIA26	8
Regulation of Rubisco activity by interaction with chloroplast metabolites	8
Skin in the game: pannexin channels in healthy and cancerous skin	8
Correction: Proteasome and thiol involvement in quality control of glycosylphosphatidylinositol anchor addition	8
Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2α phosphorylation	7
Loss of peroxiredoxin 6 alters lipid composition and distribution resulting in increased sensitivity to ferroptosis	7
De novo cyclic peptides allow visualisation of the monomeric and functional amyloid conformations of the kinase RIPK3	7
JMJD6 and YBX1 physically interact and regulate HOTAIR proximal promoter	7
Pyroptotic executioner pore-forming protein gasdermin D forms oligomeric assembly and exhibits amyloid-like attributes that could contribute for its pore-forming function	7
Into the fold: advances in understanding aPKC membrane dynamics	7

Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential	7
Excess Wnt in neurological disease	7
Extracellular vesicle-linked vitamin B12 acquisition via novel binding proteins in Bacteroides thetaiotaomicron	7
Colonic ketogenesis, a microbiota-regulated process, contributes to blood ketones and protects against colitis in mice	7
Chilling or chemical induction of dormancy release in blackcurrant (Ribes nigrum) buds is associated with characteristic shifts in metabolite profiles	7
Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors	7
Understanding single stranded DNA gaps: from formation to fate	7
Root system growth and development responses to elevated CO2: underlying signalling mechanisms and role in improving plant CO2 capture and soil C storage	7
A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11	7
Biochemical investigations of polyphenol degradation enzymes in the phototrophic bacterium Rubrivivax gelatinosus	7
Chaetocin disrupts the SUV39H1–HP1 interaction independent of SUV39H1 methyltransferase activity	6
A prescription for engineering PFAS biodegradation	6
Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity	6
Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach	6
Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia	6
E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease	6
Histone supply: a precious commodity for cell identity	6
Target discrimination and PAM profiling of the Thermotoga maritima type I-B CRISPR system	6
Role of LRRK2 in axonal transport and Parkinson’s disease	6
Protein targeting by the itaconate family in immunity and inflammation	6
LRRK2-mediated mitochondrial dysfunction in Parkinson’s disease	6
The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress	6
Investigating the differential structural organization and gene expression regulatory networks of lamin A Ig fold domain mutants of muscular dystrophy	6
Efficient production of fully active, SARS-CoV-2-priming, wildtype TMPRSS2 ectodomain via co-expression of HAI-2 allows for both auto- and cross-activation mechanisms	6
Involvement of hcp2 on maintaining cell wall integrity and pathogenicity of Vibrio alginolyticus by modula	6
Targeting calcineurin: a synergistic strategy with caspofungin to induce farnesol-mediated quorum sensing in Nakaseomyces glabrata —an inoculum-dependent	6
Correction: Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366	6
Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate	6
Long-range electron proton coupling in respiratory complex I — insights from molecular simulations of the quinone chamber and antiporter-like subunits	6
NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes	6
Correction: Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex	6
Vitamin K3 inhibits FtsZ assembly, disrupts the Z-ring in Streptococcus pneumoniae and displays anti-pneumococcal activity	6
Paraquat resistance mutations have differential effects on plant fitness in two rice cultivars	6
Dynamic interactions between SPX proteins, the ubiquitination machinery, and signalling molecules for stress adaptation at a whole-plant level	6
Exploring the dynamics and interactions of the N-myc transactivation domain through solution nuclear magnetic resonance spectroscopy	5
ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding	5
The function of BK channels extracted and purified within SMALPs	5
Sperm induce a secondary increase in ATP levels in mouse eggs that is independent of Ca2+ oscillations	5
Multifaceted roles of Epac signaling in renal functions	5
Telomerase RNA evolution: a journey from plant telomeres to broader eukaryotic diversity	5
The genetic and molecular basis of a connexin-linked skin disease	5
Trypanosomatid histones: the building blocks of the epigenetic code of highly divergent eukaryotes	5
Metal-sensing properties of the disordered loop from the Arabidopsis metal transceptor IRT1	5
Post-translational modifications of triosephosphate isomerase reveal metabolic vulnerabilities in T-ALL: effect of combining dichloroacetic acid and the PPI rabeprazole	5
Correction: Bioinformatic and experimental evidence for suicidal and catalytic plant THI4s	5
From the ‘black box' to ‘domino effect' mechanism: what have we learned from the structures of respiratory complex I	5
Opposite effects of spermidine and GC7 in cell culture are dictated by distinct molecular targets	5
Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity	5
UBE2A/B is the trans-acting factor mediating mechanotransduction and contact inhibition	5
Photocrosslinking Activity-Based Probes to Capture the Dynamics of Ubiquitin RING E3 Ligase Interactions	5
Artemether and Euphorbia factor L9 suppress kynurenine production through distinct effects on tryptophan metabolism	5
Macrophage-specific N-terminal truncation of Plin2 limits the size of lipid droplets	5
Regulation of the mitotic chromosome folding machines	5
Development of circadian rhythms in mammalian systems	5
Mitophagy in yeast: known unknowns and unknown unknowns	5
How do cells stiffen?	5
Multiple transactivation domains of EZH2 bind to the TAZ2 domain of p300 and stimulate the acetyltransferase function of p300	5
ChIP happens: from biochemical origins to the modern omics toolbox for understanding steroid hormone receptors	5
Activating mutations drive human MEK1 kinase using a gear-shifting mechanism	5
High tide or low tide: the transport and metabolism of mitochondrial nucleotides	5
Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyte	5
Understanding interleukin 11 as a disease gene and therapeutic target	5
Membrane disruption attenuates agonist potency in prostanoid receptors	4
Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration	4
WHIRLY proteins maintain seed longevity by effects on seed oxygen signalling during imbibition	4
Short- and long-term warming events on photosynthetic physiology, growth, and yields of field grown crops	4
Targeting the alternative oxidase (AOX) for human health and food security, a pharmaceutical and agrochemical target or a rescue mechanism?	4
Correction: Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers	4
Sulfoquinovosyl diacylglycerol is required for dimerisation of the Rhodobacter sphaeroides reaction centre-light harvesting 1 core complex	4
RNMT-dependent RNA cap methylation in health and disease	4
Retraction: Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155	4
Photoaffinity labelling displacement assay using multiple recombinant protein domains	4
Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development	4
PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain	4
How many kinases are druggable? A review of our current understanding	4
A guide to ERK dynamics, part 1: mechanisms and models	4
An efficient triose phosphate synthesis and distribution in wheat provides tolerance to higher field temperatures	4
Comparative analysis of canine and human HtrA2 to delineate its role in apoptosis and cancer	4
Retraction: Comparing calpain- and caspase-3-mediated degradation patterns in traumatic brain injury by differential proteome analysis	4
Gα12 and Gα13 proteins are required for transforming growth factor-β-induced myofibroblast differentiation	4
Non-cross-linking advanced glycation end products affect prohormone processing	4
Validation of GCN5L1/BLOC1S1/BLOS1 antibodies using knockout cells and tissue	4
Activin E is a transforming growth factor β ligand that signals specifically through activin receptor-like kinase 7	4
Inherited disease-linked arginine76/75 mutants in Cx50 and Cx45 showed impaired homotypic and heterotypic gap junction function, but not Cx43	4
Thermoregulated transcriptomics: the molecular basis and biological significance of temperature-dependent alternative splicing	4
Evolution of the conformational ensemble and allosteric networks of apoptotic caspases in chordates	4
Genotoxic effects of the major alkylation damage N7-methylguanine and methyl formamidopyrimidine	4
Inhibition of RIPK1 or RIPK3 kinase activity post ischemia-reperfusion reduces the development of chronic kidney injury	4
Binding partners regulate unfolding of myosin VI to activate the molecular motor	3
Cardiac substrate metabolism in type 2 diabetes	3
GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration	3
Histone modification cross-talk: analytical tools and molecular mechanisms	3
Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway	3
Impact of climate perturbations on seeds and seed quality for global agriculture	3
Proteomic analysis reveals inhibition of mevalonate and glycolysis pathways in hepatocytes by 27-hydroxycholesterol	3