Biochemical Journal

Article	Citations
Michael D. Waterfield	961
A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity	224
Cas11 augments Cascade functions in type I-E CRISPR system but is redundant for gene silencing and plasmid interference	217
Development of an OTUD1 ubiquitin variant inhibitor	114
Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor	75
Identification of inhibitors of human ChaC1, a cytoplasmic glutathione degrading enzyme through high throughput screens in yeast	73
Mutational insights into human kynurenine aminotransferase 1: modulation of transamination and β-elimination activities across diverse substrates	61
Respiratory epithelial cell types, states and fates in the era of single-cell RNA-sequencing	61
A curated list of targeted optimized promiscuous ketoreductases (TOP-K)	59
In search for structural targets for engineering d-amino acid transaminase: modulation of pH optimum and substrate specificity	56
Programmed cell death: the pathways to severe COVID-19?	55
Aurora A binds to the transactivation domain of c-Myc and recognizes the phosphorylated N-terminal degron motif	54
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells	54
Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method	53
Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane	51
A guide to ERK dynamics, part 2: downstream decoding	51
Combinatorial approaches for mitigating resistance to KRAS-targeted therapies	48
Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel–Lindau syndrome	46
Expression of neuronal NO synthase α- and β-isoforms in skeletal muscle of mice	46
The C-terminal structure of the N6-methyladenosine deaminase YerA and its role in deamination	45
Calcium signalling components underlying NPK homeostasis: potential avenues for exploration	43
Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation	41
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses	40
BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia	39
Improved furfural tolerance in Escherichia coli mediated by heterologous NADH-dependent benzyl alcohol dehydrogenases	36

CORM-3 induces DNA damage through Ru(II) binding to DNA	35
The atypical thioredoxin ‘Alr2205’, a newly identified partner of the typical 2-Cys-Peroxiredoxin, safeguards the cyanobacterium Anabaena from oxidative stress	34
TOR complex 2 is a master regulator of plasma membrane homeostasis	33
Serine acetyltransferase from Neisseria gonorrhoeae; structural and biochemical basis of inhibition	33
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications	31
Characterisation of an influenza B virus-derived peptide presented by HLA-B*18:01	29
Expression of Concern: Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway	29
Identification and characterization of the Doublesex gene and its mRNA isoforms in the brine shrimp Artemia franciscana	28
De novo talin-1 variant L353F connects multifaceted clinical symptoms to alterations in talin-1 function	27
Towards ‘end-to-end’ analysis and understanding of biological timecourse data	27
Protein kinase A and local signaling in cancer	27
Sequence variation in the active site of mobile colistin resistance proteins is evolutionarily accommodated through inter-domain interactions	27
RhoGAP6 interacts with COPI to regulate protein transport	26
Correction: Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity.	26
The role of mitochondrial RNA association for mitochondrial homeostasis in neurons	26
Proteotoxic stresses stimulate dissociation of UBL4A from the tail-anchored protein recognition complex	26
Lead induces the upregulation of protein arginine methyltransferase 5 possibly by its promoter demethylation	24
Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues	24
Cryo-EM structure of human MG53 homodimer	23
FoxO transcription factors in mitochondrial homeostasis	23
Interplay of constipation, intestinal barrier dysfunction and fungal exposome in aetiopathogenesis of Parkinson’s disease: hypothesis with supportive data	23
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator	23
Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?	23
Interactions between insulin and exercise	23
Correction: The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h	22
The uncharacterized protein ZNF200 interacts with PRMT3 and aids its stability and nuclear translocation	22
Structure and function of MDM2 and MDM4 in health and disease	21
Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway	21
Alphabetti kinase Spaghetti: the complex roles of IKKα and β in the canonical NF-κB pathway	20
Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling	20
NAD-catabolizing ectoenzymes of Schistosoma mansoni	20
Gut reactions and gut instincts: regulation of intestinal homeostasis by receptor guanylyl cyclase C (GC-C)	20
Thermodynamic analysis of Zα domain-nucleic acid interactions	19
Yop1 stability and membrane curvature generation propensity are controlled by its oligomerisation interface	18
GLUT4 On the move	18
Gibberellin-biosynthetic ent-kaurene synthases in higher plants do not require their non-catalytic domains for the catalysis	18
Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis	18
Retraction: Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin	18
Ubiquitin E3 ligases in the plant Arg/N-degron pathway	18
Adapting to change: resolving the dynamic and dual roles of NCK1 and NCK2	17
Retraction: Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure	17
The structure and function of modular Escherichia coli O157:H7 bacteriophage FTBEc1 endolysin, LysT84: defining a new endolysin catalytic subfamily	17
Functional analysis and transcriptional profiling of non-coding RNAs in yeast	17
Elevated CO2 alters photosynthesis, growth and susceptibility to powdery mildew of oak seedlings	17
Proteostasis of immune checkpoint receptors	17
IFIT3 (interferon induced protein with tetratricopeptide repeats 3) modulates STAT1 expression in small extracellular vesicles	16
Leukotriene B4 receptor 1 does not mediate disease progression in a mouse model of liver fibrosis	16
Targeting bacterial degradation machinery as an antibacterial strategy	16
Exopolysaccharide is detrimental for the symbiotic performance of Sinorhizobium fredii HH103 mutants with a truncated lipopolysaccharide core	16
Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system	15

Comparison of Classical P81 and SVI-P Cation-Exchange Papers in Radiometric Protein Kinase Assays	15
Itaconate utilisation by the human pathogen Pseudomonas aeruginosa requires uptake via the IctPQM TRAP transporter	15
Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2	15
EZH2 promotes chemoresistance in colorectal cancer by inhibiting autophagy through NRP1 suppression	15
The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors	15
Activity-based probes for dynamic characterisation of polysaccharide-degrading enzymes	15
The peculiar properties of mitochondrial carriers of the SLC25 family	14
Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes	14
Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth	14
From the Belousov–Zhabotinsky reaction to biochemical clocks, traveling waves and cell cycle regulation	14
Editorial Note: Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling	14
Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery	14
Abscisic acid triggers vitamin E accumulation by transient transcript activation of VTE5 and VTE6 in sweet cherry fruits	14
LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin	14
Distinct interactors define the p63 transcriptional signature in epithelial development or cancer	14
Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway	13
Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5	13
Activation and manipulation of inflammasomes and pyroptosis during bacterial infections	13
Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity	13
Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain	13
Proteomic mapping and optogenetic manipulation of membrane contact sites	13
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding	13
Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity	13
DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability	13
Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlierAtITPK4	13
Sequence rules for a long SPOP-binding degron required for protein ubiquitylation	12
Genetic modulation of CWD prion propagation in cervid PrP Drosophila	12
PHF1 compartmentalizes PRC2 via phase separation	12
The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms	12
TAT–RHIM: a more complex issue than expected	12
The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase	11
Macropinocytosis: mechanisms and regulation	11
Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity	11
Key structural role of a conserved cis-proline revealed by the P285S variant of soybean serine hydroxymethyltransferase 8	11
A Plasmodium falciparum ubiquitin-specific protease (PfUSP) is essential for parasite survival and its disruption enhances artemisinin efficacy	11
Penetrant PKCb mutation in ATLL displays a mixed gain-of-function	11
The impact of cell states on heterochromatin dynamics	11
Dynamic interchange of local residue–residue interactions in the largely extended single alpha-helix in Drebrin	11
Synthesis, biochemical characterization and in silico investigation of 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid derivatives: dual action mode inhibitors of urease and virulent bacterial	10
Mechanistic diversity in MHC class I antigen recognition	10
Beyond protein modification: the rise of non-canonical ADP-ribosylation	10
Correction: NAD+-consuming enzymes in immune defense against viral infection	10
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing	10
Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation	10
The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes	10
Overexpression of phospholipid: diacylglycerol acyltransferase in Brassica napus results in changes in lipid metabolism and oil accumulation	10
Genome damage accumulated in seed ageing leads to plant genome instability and growth inhibition	10
The C-terminal region of phytoene synthase is a key element to control carotenoid biosynthesis in the haloarchaeon Haloferax volcanii	10
The role of the γ subunit in the photosystem of the lowest-energy phototrophs	10
The monodomain Kunitz protein EgKU-7 from the dog tapeworm Echinococcus granulosus is a high-affinity trypsin inhibitor with two interaction sites	9
Plant adaptation to climate change	9
The bacterial transcription terminator, Rho, functions as an RNA:DNA hybrid (RDH) helicase in vivo	9
Revamped Role for Approved Drug: Integrative Computational and Biophysical Analysis of Saquinavir's PAD4 Inhibition for Rheumatoid Arthritis	9
Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma	9
And… cut! – how conformational regulation of CRISPR-Cas effectors directs nuclease activity	9
Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2	9
The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?	9
Phosphorus-specific, liquid chromatography inductively coupled plasma mass-spectrometry for analysis of inositol phosphate and inositol pyrophosphate metabolism	9
Site IQ in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions	9
Common and unique features of glycosylation and glycosyltransferases in African trypanosomes	9
Shaping mitochondria through fed–fast and circadian cycles	9
The C-terminal sequences of Bcl-2 family proteins mediate interactions that regulate cell death	9
AmyloGram Reveals Amyloidogenic Potential in Stroke Thrombus Proteomes	9
RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers	9
Characterization of ADAT2/3 molecules in Trypanosoma cruzi and regulation of mucin gene expression by tRNA editing	9
Entangling roles of cholesterol-dependent interaction and cholesterol-mediated lipid phase heterogeneity in regulating listeriolysin O pore-formation	9
Development of a colorimetric assay for the detection of SARS-CoV-2 3CLpro activity	9
ISGylation-independent protection of cell growth by USP18 following interferon stimulation	8
Biochemical investigations of polyphenol degradation enzymes in the phototrophic bacterium Rubrivivax gelatinosus	8
The role of eIF2 phosphorylation in cell and organismal physiology: new roles for well-known actors	8
The NFkB activation domain is 14-amino-acid-long variant of the 9aaTAD	8
Correction: Proteasome and thiol involvement in quality control of glycosylphosphatidylinositol anchor addition	8
JMJD6 and YBX1 physically interact and regulate HOTAIR proximal promoter	8
LASP-1 interacts with ErbB2 in ovarian cancer cells	8
A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11	8
Loss of peroxiredoxin 6 alters lipid composition and distribution resulting in increased sensitivity to ferroptosis	8
Root system growth and development responses to elevated CO2: underlying signalling mechanisms and role in improving plant CO2 capture and soil C storage	8
Extracellular Vesicle-Linked Vitamin B12 Acquisition via Novel Binding Proteins in Bacteroides thetaiotaomicron	8
The role of phosphorylation in calmodulin-mediated gating of human AQP0	8
Pyroptotic executioner pore-forming protein gasdermin D forms oligomeric assembly and exhibits amyloid-like attributes that could contribute for its pore-forming function	8

Skin in the game: pannexin channels in healthy and cancerous skin	8
α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif	8
Regulation of Rubisco activity by interaction with chloroplast metabolites	8
Structure of the major oxidative damage 7,8-dihydro-8-oxoguanine presented into a catalytically competent DNA glycosylase	8
Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors	7
Role of LRRK2 in axonal transport and Parkinson’s disease	7
Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly	7
Dynamic interactions between SPX proteins, the ubiquitination machinery, and signalling molecules for stress adaptation at a whole-plant level	7
Chaetocin disrupts the SUV39H1–HP1 interaction independent of SUV39H1 methyltransferase activity	7
Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential	7
Chilling or chemical induction of dormancy release in blackcurrant (Ribes nigrum) buds is associated with characteristic shifts in metabolite profiles	7
Excess iodide-induced reactive oxygen species elicit iodide efflux via β-tubulin-associated ClC-3 in thyrocytes	7
Into the fold: advances in understanding aPKC membrane dynamics	7
Systems approaches to investigate the role of NF-κB signaling in aging	7
Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity	7
Long-range electron proton coupling in respiratory complex I — insights from molecular simulations of the quinone chamber and antiporter-like subunits	7
Colonic ketogenesis, a microbiota-regulated process, contributes to blood ketones and protects against colitis in mice	7
No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors	7
Vitamin K3 inhibits FtsZ assembly, disrupts the Z-ring in Streptococcus pneumoniae and displays anti-pneumococcal activity	7
Excess Wnt in neurological disease	7
Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs	7
NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes	7
Ferroptosis in plants: regulation of lipid peroxidation and redox status	7
The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress	7
Histone supply: a precious commodity for cell identity	7
Quantitative metabolic fluxes regulated by trans-omic networks	7
Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate	7
Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2α phosphorylation	7
Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia	7
A prescription for engineering PFAS biodegradation	6
Multiple transactivation domains of EZH2 bind to the TAZ2 domain of p300 and stimulate the acetyltransferase function of p300	6
Investigating the differential structural organization and gene expression regulatory networks of lamin A Ig fold domain mutants of muscular dystrophy	6
Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach	6
Activating mutations drive human MEK1 kinase using a gear-shifting mechanism	6
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death	6
Telomerase RNA evolution: a journey from plant telomeres to broader eukaryotic diversity	6
Correction: Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex	6
Multifaceted roles of Epac signaling in renal functions	6
UBE2A/B is the trans-acting factor mediating mechanotransduction and contact inhibition	6
N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum	6
Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity	6
E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease	6
Protein targeting by the itaconate family in immunity and inflammation	6
Correction: Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366	6
Paraquat resistance mutations have differential effects on plant fitness in two rice cultivars	6
The genetic and molecular basis of a connexin-linked skin disease	6
LRRK2-mediated mitochondrial dysfunction in Parkinson’s disease	6
From the ‘black box' to ‘domino effect' mechanism: what have we learned from the structures of respiratory complex I	6
Sperm induce a secondary increase in ATP levels in mouse eggs that is independent of Ca2+ oscillations	5
Exploring the dynamics and interactions of the N-myc transactivation domain through solution nuclear magnetic resonance spectroscopy	5
Development of circadian rhythms in mammalian systems	5
AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue	5
Evolution of the conformational ensemble and allosteric networks of apoptotic caspases in chordates	5
RNMT-dependent RNA cap methylation in health and disease	5
Comparative analysis of canine and human HtrA2 to delineate its role in apoptosis and cancer	5
Sulfoquinovosyl diacylglycerol is required for dimerisation of the Rhodobacter sphaeroides reaction centre-light harvesting 1 core complex	5
Mitophagy in yeast: known unknowns and unknown unknowns	5
High tide or low tide: the transport and metabolism of mitochondrial nucleotides	5
Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyte	5
Trypanosomatid histones: the building blocks of the epigenetic code of highly divergent eukaryotes	5
ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding	5
Inherited disease-linked arginine76/75 mutants in Cx50 and Cx45 showed impaired homotypic and heterotypic gap junction function, but not Cx43	5
An efficient triose phosphate synthesis and distribution in wheat provides tolerance to higher field temperatures	5
Genotoxic effects of the major alkylation damage N7-methylguanine and methyl formamidopyrimidine	5
NAD+-consuming enzymes in immune defense against viral infection	5
How do cells stiffen?	5
The function of BK channels extracted and purified within SMALPs	5
Correction: Bioinformatic and experimental evidence for suicidal and catalytic plant THI4s	5
Regulation of the mitotic chromosome folding machines	5
Understanding interleukin 11 as a disease gene and therapeutic target	5
Inhibition of RIPK1 or RIPK3 kinase activity post ischemia-reperfusion reduces the development of chronic kidney injury	5
Thermoregulated transcriptomics: the molecular basis and biological significance of temperature-dependent alternative splicing	5
Metal-sensing properties of the disordered loop from the Arabidopsis metal transceptor IRT1	5
Proteomic analysis reveals inhibition of mevalonate and glycolysis pathways in hepatocytes by 27-hydroxycholesterol	4
Revisiting the roles of cAMP signalling in the progression of prostate cancer	4
Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers	4
A guide to ERK dynamics, part 1: mechanisms and models	4
Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state	4
Binding partners regulate unfolding of myosin VI to activate the molecular motor	4
Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development	4
Divergent binding mode for a protozoan BRC repeat to RAD51	4
Higher expression of proline dehydrogenase altered mitochondrial function and increased Trypanosoma cruzi differentiation in vitro and in the insect vector	4
Membrane disruption attenuates agonist potency in prostanoid receptors	4
How many kinases are druggable? A review of our current understanding	4
Retraction: Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155	4
Structural insights into allosteric inhibition of HRI kinase by heme binding via HDX-MS	4
Unconventional binding of Calmodulin to CHK2 kinase inhibits catalytic activity	4
The PRL2 phosphatase up-regulates miR-21 through activation of the JAK2/STAT3 pathway to down-regulate the PTEN tumor suppressor	4
Lhs1 dependent ERAD is determined by transmembrane domain context	4
Genetically engineered human embryonic kidney cells as a novel vehicle for dual patch clamp study of human gap junction channels	4
Gα12 and Gα13 proteins are required for transforming growth factor-β-induced myofibroblast differentiation	4
Short- and long-term warming events on photosynthetic physiology, growth, and yields of field grown crops	4
The consequence of ATP synthase dimer angle on mitochondrial morphology studied by cryo-electron tomography	4
Integration of machine learning with computational structural biology of plants	4
Interaction of the periplasmic chaperone SurA with the inner membrane protein secretion (SEC) machinery	4