Biochemical Journal

Article	Citations
Michael D. Waterfield	142
Identification of inhibitors of human ChaC1, a cytoplasmic glutathione degrading enzyme through high throughput screens in yeast	101
Cas11 augments Cascade functions in type I-E CRISPR system but is redundant for gene silencing and plasmid interference	94
Mutational insights into human kynurenine aminotransferase 1: modulation of transamination and β-elimination activities across diverse substrates	91
A curated list of targeted optimized promiscuous ketoreductases (TOP-K)	86
A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity	85
Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor	69
In search for structural targets for engineering d-amino acid transaminase: modulation of pH optimum and substrate specificity	68
Rules of the road: how to turn off kinesin motors	63
Combinatorial approaches for mitigating resistance to KRAS-targeted therapies	63
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells	53
Proteolytic coordination of the OXPHOS Life Cycle	47
Cold exposure remodels bile acid metabolism in a mouse strain- and tissue-specific manner	45
Respiratory epithelial cell types, states and fates in the era of single-cell RNA-sequencing	43
Modulating backbone flexibility in hydroxamate siderophores for improved iron chelation and peptide nucleic acid delivery into bacteria	39
Development of an OTUD1 ubiquitin variant inhibitor	39
A guide to ERK dynamics, part 2: downstream decoding	38
Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method	38
Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane	38
Aurora A binds to the transactivation domain of c-Myc and recognizes the phosphorylated N-terminal degron motif	37
Expression of neuronal NO synthase α- and β-isoforms in skeletal muscle of mice	35
BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia	32
The C-terminal structure of the N6-methyladenosine deaminase YerA and its role in deamination	32
The atypical thioredoxin ‘Alr2205’, a newly identified partner of the typical 2-Cys-Peroxiredoxin, safeguards the cyanobacterium Anabaena from oxidative stress	31
Calcium signalling components underlying NPK homeostasis: potential avenues for exploration	30

Bioinformatic assessment of the potential amyloidogenicity of the human and evolutionarily more ancient proteomes	28
TOR complex 2 is a master regulator of plasma membrane homeostasis	28
Identification and functional characterization of two CXCL17 paralogs from zebrafish	28
De novo talin-1 variant L353F connects multifaceted clinical symptoms to alterations in talin-1 function	27
Oligomeric assemblies of plant biotin carboxylase revealed by cryo-EM and cross-linking	27
The role of linker length and composition in actin binding and bundling by palladin	27
The role of mitochondrial RNA association for mitochondrial homeostasis in neurons	26
RhoGAP6 interacts with COPI to regulate protein transport	26
Expression of Concern: Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway	25
Lead induces the upregulation of protein arginine methyltransferase 5 possibly by its promoter demethylation	24
Structural characterization of OsPDIL2-3, a rice protein disulfide isomerase involved in prolamin accumulation	23
Correction: Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity.	23
Identification and characterization of the Doublesex gene and its mRNA isoforms in the brine shrimp Artemia franciscana	22
Cryo-EM structure of human MG53 homodimer	22
Sequence variation in the active site of mobile colistin resistance proteins is evolutionarily accommodated through inter-domain interactions	22
Protein kinase A and local signaling in cancer	21
Proteotoxic stresses stimulate dissociation of UBL4A from the tail-anchored protein recognition complex	21
Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues	21
Interplay of constipation, intestinal barrier dysfunction and fungal exposome in aetiopathogenesis of Parkinson’s disease: hypothesis with supportive data	21
Characterisation of an influenza B virus-derived peptide presented by HLA-B*18:01	20
The uncharacterized protein ZNF200 interacts with PRMT3 and aids its stability and nuclear translocation	20
Clostridium beijerinckii displays a soluble [FeFe]-hydrogenase/formate dehydrogenase enzyme complex that links H2 and CO2 metabolism	20
Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis	20
Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?	20
Correction: The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h	20
Serendipitous discovery of an allosteric inhibitor binding groove in the proline biosynthetic enzyme pyrroline-5-carboxylate reductase 1	19
Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway	19
Use of hydrogen deuterium exchange mass spectrometry in tandem with modern structural biology	19
Thermodynamic analysis of Zα domain-nucleic acid interactions	19
Gibberellin-biosynthetic ent-kaurene synthases in higher plants do not require their non-catalytic domains for the catalysis	19
VDR/RXR antagonizes calcineurin-activated NFAT1, an essential regulator of Coronin-1A expression and Mycobacterial persistence	18
Gut reactions and gut instincts: regulation of intestinal homeostasis by receptor guanylyl cyclase C (GC-C)	18
Retraction: Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin	18
Structure and function of MDM2 and MDM4 in health and disease	18
Retraction: Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure	17
An expanded role for single-cell chemical genomics profiling in drug discovery	17
Yop1 stability and membrane curvature generation propensity are controlled by its oligomerisation interface	17
Functional analysis and transcriptional profiling of non-coding RNAs in yeast	16
Ubiquitin E3 ligases in the plant Arg/N-degron pathway	16
Targeting bacterial degradation machinery as an antibacterial strategy	16
Combination amino acids and glucose effects on insulin and GLP-1 secretion	16
Elevated CO2 alters photosynthesis, growth and susceptibility to powdery mildew of oak seedlings	16
Proteostasis of immune checkpoint receptors	16
Adapting to change: resolving the dynamic and dual roles of NCK1 and NCK2	16
Leukotriene B4 receptor 1 does not mediate disease progression in a mouse model of liver fibrosis	15
Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2	15
Peeking behind the carbocation: identification of (alternative) catalytic bases in the class II active site of conifer resin acid diterpene synthases	15
Comparison of Classical P81 and SVI-P Cation-Exchange Papers in Radiometric Protein Kinase Assays	15
An S752D activation loop mutation dynamically primes Muscle-Specific Kinase for activation	15
The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors	15

Exopolysaccharide is detrimental for the symbiotic performance of Sinorhizobium fredii HH103 mutants with a truncated lipopolysaccharide core	15
Editorial Note: Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling	15
A metabolite extracted from Escherichia coli suppresses tau aggregation	14
EZH2 promotes chemoresistance in colorectal cancer by inhibiting autophagy through NRP1 suppression	14
Towards broad-spectrum antiviral drugs: inhibition of transmembrane serine proteases	14
Retraction: A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells	14
Activity-based probes for dynamic characterisation of polysaccharide-degrading enzymes	14
Itaconate utilisation by the human pathogen Pseudomonas aeruginosa requires uptake via the IctPQM TRAP transporter	14
Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlierAtITPK4	13
Docking in the Abies grandis abietaenol synthase to investigate the mechanism underlying conifer resin acid diterpene synthase evolution	13
Abscisic acid triggers vitamin E accumulation by transient transcript activation of VTE5 and VTE6 in sweet cherry fruits	13
Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity	13
Retraction: A new Mad2-interacting domain of Cdc20 is critical for the function of Mad2–Cdc20 complex in the spindle assembly checkpoint	13
The peculiar properties of mitochondrial carriers of the SLC25 family	13
Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery	13
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding	13
Dynamic interchange of local residue–residue interactions in the largely extended single alpha-helix in Drebrin	12
Genetic modulation of CWD prion propagation in cervid PrP Drosophila	12
Proteomic mapping and optogenetic manipulation of membrane contact sites	12
Sequence rules for a long SPOP-binding degron required for protein ubiquitylation	12
Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5	12
Penetrant PKCβ mutation in ATLL displays a mixed gain-of-function	11
A Plasmodium falciparum ubiquitin-specific protease (PfUSP) is essential for parasite survival and its disruption enhances artemisinin efficacy	11
Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain	11
Synthesis, biochemical characterization and in silico investigation of 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid derivatives: dual action mode inhibitors of urease and virulent bacterial	11
Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity	11
PHF1 compartmentalizes PRC2 via phase separation	11
Expression and characterization of an endo-β-1,6-galactanase from Arabidopsis thaliana	11
Macropinocytosis: mechanisms and regulation	11
Mitophagy: an emerging therapeutic target in mitochondrial diseases	11
Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity	11
DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability	11
The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms	11
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing	11
When sweetness overflows: fructose influences microbial and metabolic dysregulation	10
Genome damage accumulated in seed ageing leads to plant genome instability and growth inhibition	10
The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes	10
The C-terminal sequences of Bcl-2 family proteins mediate interactions that regulate cell death	10
The role of the γ subunit in the photosystem of the lowest-energy phototrophs	10
The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase	10
Modulation of Nur77–DNA interactions by the glucocorticoid receptor	10
Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation	10
Key structural role of a conserved cis-proline revealed by the P285S variant of soybean serine hydroxymethyltransferase 8	10
The impact of cell states on heterochromatin dynamics	10
The C-terminal region of phytoene synthase is a key element to control carotenoid biosynthesis in the haloarchaeon Haloferax volcanii	10
Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2	10
The bacterial transcription terminator, Rho, functions as an RNA:DNA hybrid (RDH) helicase in vivo	9
Plant adaptation to climate change	9
Entangling roles of cholesterol-dependent interaction and cholesterol-mediated lipid phase heterogeneity in regulating listeriolysin O pore-formation	9
Revamped Role for Approved Drug: Integrative Computational and Biophysical Analysis of Saquinavir's PAD4 Inhibition for Rheumatoid Arthritis	9
Structural basis for inhibition of SpyCas9 by the anti-CRISPR protein AcrIIA26	9
AmyloGram reveals amyloidogenic potential in stroke thrombus proteomes	9
Molecular foundations of collagen triple helical assembly: the central role of prolyl-4-hydroxylation	9
Inducing TRIB2-targeted protein degradation to reverse chemoresistance in acute myeloid leukaemia	9
Common and unique features of glycosylation and glycosyltransferases in African trypanosomes	9
And… cut! – how conformational regulation of CRISPR-Cas effectors directs nuclease activity	9
Shaping mitochondria through fed–fast and circadian cycles	9
Modulation of Ube2R1 activity by a nanobody that binds near its N-terminus	9
Phosphorus-specific, liquid chromatography inductively coupled plasma mass spectrometry for analysis of inositol phosphate and inositol pyrophosphate metabolism	9
The monodomain Kunitz protein EgKU-7 from the dog tapeworm Echinococcus granulosus is a high-affinity trypsin inhibitor with two interaction sites	9
The NFkB activation domain is 14-amino-acid-long variant of the 9aaTAD	9
RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers	9
Biochemical investigations of polyphenol degradation enzymes in the phototrophic bacterium Rubrivivax gelatinosus	8
De novo cyclic peptides allow visualisation of the monomeric and functional amyloid conformations of the kinase RIPK3	8
ISGylation-independent protection of cell growth by USP18 following interferon stimulation	8
Site IQ in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions	8
Structure of the major oxidative damage 7,8-dihydro-8-oxoguanine presented into a catalytically competent DNA glycosylase	8
Pyroptotic executioner pore-forming protein gasdermin D forms oligomeric assembly and exhibits amyloid-like attributes that could contribute for its pore-forming function	8
Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma	8
The role of phosphorylation in calmodulin-mediated gating of human AQP0	8
A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11	8
Understanding single stranded DNA gaps: from formation to fate	8
Regulation of Rubisco activity by interaction with chloroplast metabolites	8
Correction: Proteasome and thiol involvement in quality control of glycosylphosphatidylinositol anchor addition	8
Loss of peroxiredoxin 6 alters lipid composition and distribution resulting in increased sensitivity to ferroptosis	7
Excess Wnt in neurological disease	7
Chilling or chemical induction of dormancy release in blackcurrant (Ribes nigrum) buds is associated with characteristic shifts in metabolite profiles	7
Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential	7
Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia	7
Skin in the game: pannexin channels in healthy and cancerous skin	7

Extracellular vesicle-linked vitamin B12 acquisition via novel binding proteins in Bacteroides thetaiotaomicron	7
A prescription for engineering PFAS biodegradation	7
Colonic ketogenesis, a microbiota-regulated process, contributes to blood ketones and protects against colitis in mice	7
Targeting calcineurin: a synergistic strategy with caspofungin to induce farnesol-mediated quorum sensing in Nakaseomyces glabrata —an inoculum-dependent	7
Root system growth and development responses to elevated CO2: underlying signalling mechanisms and role in improving plant CO2 capture and soil C storage	7
Into the fold: advances in understanding aPKC membrane dynamics	7
JMJD6 and YBX1 physically interact and regulate HOTAIR proximal promoter	7
Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors	7
Efficient production of fully active, SARS-CoV-2-priming, wildtype TMPRSS2 ectodomain via co-expression of HAI-2 allows for both auto- and cross-activation mechanisms	7
Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2α phosphorylation	7
Photocross-linking activity-based probes to capture the dynamics of ubiquitin RING E3 ligase interactions	6
Telomerase RNA evolution: a journey from plant telomeres to broader eukaryotic diversity	6
Paraquat resistance mutations have differential effects on plant fitness in two rice cultivars	6
Multiple transactivation domains of EZH2 bind to the TAZ2 domain of p300 and stimulate the acetyltransferase function of p300	6
Protein targeting by the itaconate family in immunity and inflammation	6
Target discrimination and PAM profiling of the Thermotoga maritima type I-B CRISPR system	6
Role of LRRK2 in axonal transport and Parkinson’s disease	6
Correction: Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex	6
Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach	6
Activating mutations drive human MEK1 kinase using a gear-shifting mechanism	6
Long-range electron proton coupling in respiratory complex I — insights from molecular simulations of the quinone chamber and antiporter-like subunits	6
Correction: Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366	6
Chaetocin disrupts the SUV39H1–HP1 interaction independent of SUV39H1 methyltransferase activity	6
Histone supply: a precious commodity for cell identity	6
Investigating the differential structural organization and gene expression regulatory networks of lamin A Ig fold domain mutants of muscular dystrophy	6
ChIP happens: from biochemical origins to the modern omics toolbox for understanding steroid hormone receptors	6
Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity	6
Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity	6
The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress	6
Dynamic interactions between SPX proteins, the ubiquitination machinery, and signalling molecules for stress adaptation at a whole-plant level	6
Involvement of hcp2 on maintaining cell wall integrity and pathogenicity of Vibrio alginolyticus by modula	6
Exploring the dynamics and interactions of the N-myc transactivation domain through solution nuclear magnetic resonance spectroscopy	5
Metal-sensing properties of the disordered loop from the Arabidopsis metal transceptor IRT1	5
LRRK2-mediated mitochondrial dysfunction in Parkinson’s disease	5
UBE2A/B is the trans-acting factor mediating mechanotransduction and contact inhibition	5
From the ‘black box' to ‘domino effect' mechanism: what have we learned from the structures of respiratory complex I	5
Opposite effects of spermidine and GC7 in cell culture are dictated by distinct molecular targets	5
High tide or low tide: the transport and metabolism of mitochondrial nucleotides	5
Understanding interleukin 11 as a disease gene and therapeutic target	5
Trypanosomatid histones: the building blocks of the epigenetic code of highly divergent eukaryotes	5
Mitophagy in yeast: known unknowns and unknown unknowns	5
Multifaceted roles of Epac signaling in renal functions	5
The genetic and molecular basis of a connexin-linked skin disease	5
Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyte	5
Regulation of the mitotic chromosome folding machines	5
The function of BK channels extracted and purified within SMALPs	5
ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding	5
Sperm induce a secondary increase in ATP levels in mouse eggs that is independent of Ca2+ oscillations	5
Correction: Bioinformatic and experimental evidence for suicidal and catalytic plant THI4s	5
Artemether and Euphorbia factor L9 suppress kynurenine production through distinct effects on tryptophan metabolism	5
E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease	5
Macrophage-specific N-terminal truncation of Plin2 limits the size of lipid droplets	5
Development of circadian rhythms in mammalian systems	5
Post-translational modifications of triosephosphate isomerase reveal metabolic vulnerabilities in T-ALL: effect of combining dichloroacetic acid and the PPI rabeprazole	5
Mechanistic insights into acetylated histone recognition by the CECR2 bromodomain	5
Structural insights into allosteric inhibition of HRI kinase by heme binding via HDX-MS	4
PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain	4
Molecular identifiers of the evolutionarily conserved titin pseudokinase	4
Genotoxic effects of the major alkylation damage N7-methylguanine and methyl formamidopyrimidine	4
Validation of GCN5L1/BLOC1S1/BLOS1 antibodies using knockout cells and tissue	4
A guide to ERK dynamics, part 1: mechanisms and models	4
Sulfoquinovosyl diacylglycerol is required for dimerisation of the Rhodobacter sphaeroides reaction centre-light harvesting 1 core complex	4
RNMT-dependent RNA cap methylation in health and disease	4
An efficient triose phosphate synthesis and distribution in wheat provides tolerance to higher field temperatures	4
Inhibition of RIPK1 or RIPK3 kinase activity post ischemia-reperfusion reduces the development of chronic kidney injury	4
Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development	4
Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration	4
Citrate trafficking supports rewiring of mitochondrial metabolism via RTG signaling in yeast osmoadaptation	4
BMP4 signaling regulates the expression of signals and transcription factors for coordinated cytodifferentiation in the murine ureter	4
Retraction: Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155	4
Genetically engineered human embryonic kidney cells as a novel vehicle for dual patch clamp study of human gap junction channels	4
Thermoregulated transcriptomics: the molecular basis and biological significance of temperature-dependent alternative splicing	4
How many kinases are druggable? A review of our current understanding	4
Inherited disease-linked arginine76/75 mutants in Cx50 and Cx45 showed impaired homotypic and heterotypic gap junction function, but not Cx43	4
Correction: Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers	4
Gα12 and Gα13 proteins are required for transforming growth factor-β-induced myofibroblast differentiation	4
Membrane disruption attenuates agonist potency in prostanoid receptors	4
The biology of interleukin-6 family cytokines is regulated by glycosylation	4
The consequence of ATP synthase dimer angle on mitochondrial morphology studied by cryo-electron tomography	4
Non-cross-linking advanced glycation end products affect prohormone processing	4
Activin E is a transforming growth factor β ligand that signals specifically through activin receptor-like kinase 7	4
WHIRLY proteins maintain seed longevity by effects on seed oxygen signalling during imbibition	4
Short- and long-term warming events on photosynthetic physiology, growth, and yields of field grown crops	4
Retraction: Comparing calpain- and caspase-3-mediated degradation patterns in traumatic brain injury by differential proteome analysis	4
Comparative analysis of canine and human HtrA2 to delineate its role in apoptosis and cancer	4
Evolution of the conformational ensemble and allosteric networks of apoptotic caspases in chordates	4
How do cells stiffen?	4
Photoaffinity labelling displacement assay using multiple recombinant protein domains	4
Structural and mechanistic insights into protein glycosylation and glycosylphosphatidylinositol anchoring in the endoplasmic reticulum membrane	4
Polypharmacological repurposing approach identifies approved drugs as potential inhibitors of Mycobacterium tuberculosis	3
The PRL2 phosphatase up-regulates miR-21 through activation of the JAK2/STAT3 pathway to down-regulate the PTEN tumor suppressor	3
Autoregulation of the MET receptor tyrosine kinase by its intracellular juxtamembrane domain	3
The future of Forkhead box O transcription factors	3
Impact of climate perturbations on seeds and seed quality for global agriculture	3
In silico, in vitro, and in vivo characterization of thiamin-binding proteins from plant seeds	3