Biochemical Journal

Article	Citations
Effect of methyl DNA adducts on 3’-5’ exonuclease activity of human TREX1	758
GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration	188
Binding partners regulate unfolding of myosin VI to activate the molecular motor	150
The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications	120
A curated list of targeted optimized promiscuous ketoreductases (TOP-K)	87
PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies	85
Lactate cross-talk in host–pathogen interactions	82
Computational and experimental characterization of the novel ECM glycoprotein SNED1 and prediction of its interactome	76
Kinetics of the multitasking high-affinity Win binding site of WDR5 in restricted and unrestricted conditions	64
Casting iron into the cell fate mold	63
Characterization of the structural determinants of the ubiquitin-dependent proteasomal degradation of human hepatic tryptophan 2,3-dioxygenase	61
Protecting P-type plasma membrane H+-ATPases from ROS	57
Cancer cachexia: molecular mechanism and pharmacological management	54
Insights into the substrate discrimination mechanisms of methyl-CpG-binding domain 4	53
The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors	52
AMP-activated protein kinase activation suppresses leptin expression independently of adipogenesis in primary murine adipocytes	51
Into the fold: advances in understanding aPKC membrane dynamics	51
Pseudouridylation-mediated gene expression modulation	47
Ferroptosis in plants: regulation of lipid peroxidation and redox status	47
Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes	47
Elevated atmospheric carbon dioxide and plant immunity to fungal pathogens: do the risks outweigh the benefits?	47
Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers	46
Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential	42
Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia	42
Colonic ketogenesis, a microbiota-regulated process, contributes to blood ketones and protects against colitis in mice	41

The PRL2 Phosphatase Upregulates miR-21 through Activation of the JAK2/STAT3 Pathway to Downregulate the PTEN Tumor Suppressor	41
Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI	41
Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance	40
Structural and functional characterization of a mycobacterial methylenetetrahydrofolate reductase utilizing NADH as the exclusive cofactor	40
Mutagenic incorporation of inosine into DNA via T:I mismatch formation by human DNA polymerase eta (polη)	39
Identification of inhibitors of human ChaC1, a cytoplasmic glutathione degrading enzyme through high throughput screens in yeast	39
Aflatoxin biosynthesis regulators AflR and AflS: DNA binding affinity, stoichiometry, and kinetics	38
Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity	38
Abscisic acid triggers vitamin E accumulation by transient transcript activation of VTE5 and VTE6 in sweet cherry fruits	37
A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity	37
Michael D. Waterfield	35
In search for structural targets for engineering d-amino acid transaminase: modulation of pH optimum and substrate specificity	35
Revisiting the roles of cAMP signalling in the progression of prostate cancer	34
Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery	34
Chilling or chemical induction of dormancy release in blackcurrant (Ribes nigrum) buds is associated with characteristic shifts in metabolite profiles	34
Comprehensive comparative assessment of the Arabidopsis thaliana MLO2–CALMODULIN2 interaction by various in vitro and in vivo protein–protein interaction assays	32
Tick–human interactions: from allergic klendusity to the α-Gal syndrome	31
Structures of an engineered phospholipase D with specificity for secondary alcohol transphosphatidylation: insights into plasticity of substrate binding and activation	31
PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target	31
RNA processing by the CRISPR-associated NYN ribonuclease	31
A conserved NAG motif is critical to the catalytic activity of galactinol synthase, a key regulatory enzyme of RFO biosynthesis	30
Activation and manipulation of inflammasomes and pyroptosis during bacterial infections	29
Higher expression of proline dehydrogenase altered mitochondrial function and increased Trypanosoma cruzi differentiation in vitro and in the insect vector	29
Correction: Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity	28
NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes	28
Clathrin: the molecular shape shifter	28
Integration of machine learning with computational structural biology of plants	28
Combinatorial approaches for mitigating resistance to KRAS-targeted therapies	27
Regulation of chromatin accessibility by hypoxia and HIF	27
Transforming growth factor-β2-mediated mesenchymal transition in lens epithelial cells is repressed in the absence of RAGE	27
Conformational plasticity of the ULK3 kinase domain	26
Binding of the Mycobacterium tuberculosis EccCb1 ATPase double hexameric ring to the EsxAB virulence factor is enhanced by ATP	26
Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes	26
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease	25
Quantitative metabolic fluxes regulated by trans-omic networks	25
Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway	24
Interaction of the periplasmic chaperone SurA with the inner membrane protein secretion (SEC) machinery	24
Respiratory epithelial cell types, states and fates in the era of single-cell RNA-sequencing	24
Translational regulation in pathogenic and beneficial plant–microbe interactions	24
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease	24
Diversity of ACE2 and its interaction with SARS-CoV-2 receptor binding domain	23
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells	22
Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane	22
Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin	21
Regulation of B cell receptor signalling by Epstein–Barr virus nuclear antigens	21
Regulation of Tim-3 function by binding to phosphatidylserine	21
Construction of mouse cochlin mutants with different GAG-binding specificities and their use for immunohistochemistry	21
The optimal pH of AID is skewed from that of its catalytic pocket by DNA-binding residues and surface charge	21
Programmed cell death: the pathways to severe COVID-19?	20
Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma	20

Chemical biology tools for protein labelling: insights into cell–cell communication	20
Development of an OTUD1 ubiquitin variant inhibitor	20
Vitamin K3 inhibits FtsZ assembly, disrupts the Z-ring in Streptococcus pneumoniae and displays anti-pneumococcal activity	19
No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors	19
Divergent binding mode for a protozoan BRC repeat to RAD51	19
Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression	19
Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth	19
Impact of climate perturbations on seeds and seed quality for global agriculture	19
Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2α phosphorylation	19
A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes	18
A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects	18
The parkinsonism-associated protein FBXO7 cooperates with the BAG6 complex in proteasome function and controls the subcellular localization of the complex	18
Molecular basis for recognition of the Group A Carbohydrate backbone by the PlyC streptococcal bacteriophage endolysin	18
Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation	17
Charting the importance of filamin A posttranslational modifications	17
The breakthrough in protein structure prediction	17
LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin	17
Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane	17
Retraction: MAPK activation by radio waves	16
Tunneling nanotubes and related structures: molecular mechanisms of formation and function	16
Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlierAtITPK4	16
Correction: Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signaling	16
Current data processing strategies for cryo-electron tomography and subtomogram averaging	16
Biochemical basis and therapeutic potential of mitochondrial uncoupling in cardiometabolic syndrome	16
The kinetics of islet amyloid polypeptide phase-separated system and hydrogel formation are critically influenced by macromolecular crowding	16
Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by down-regulating periostin expression	15
Regulation of PARP1/2 and the tankyrases: emerging parallels	15
Excess iodide-induced reactive oxygen species elicit iodide efflux via β-tubulin-associated ClC-3 in thyrocytes	15
Intelligent host engineering for metabolic flux optimisation in biotechnology	15
Excitation energy transfer kinetics of trimeric, monomeric and subunit-depleted Photosystem I from Synechocystis PCC 6803	14
Systems approaches to investigate the role of NF-κB signaling in aging	14
Lhs1 dependent ERAD is determined by transmembrane domain context	14
Long-range electron proton coupling in respiratory complex I — insights from molecular simulations of the quinone chamber and antiporter-like subunits	14
A guide to ERK dynamics, part 2: downstream decoding	14
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding	14
GlmS mediated knock-down of a phospholipase expedite alternate pathway to generate phosphocholine required for phosphatidylcholine synthesis in Plasmodium falciparum	14
The C-terminal structure of the N6-methyladenosine deaminase YerA and its role in deamination	14
Identification of a 10-mer peptide from the death domain of MyD88 which attenuates inflammation and insulin resistance and improves glucose metabolism	14
Opposing regulation of endoplasmic reticulum retention under stress by ERp44 and PDIA6	14
Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor	14
The biochemistry and physiology of long-chain dicarboxylic acid metabolism	14
In silico, in vitro, and in vivo characterization of thiamin-binding proteins from plant seeds	14
Structural and functional organization of germ plasm condensates	13
SREBP-1c and lipogenesis in the liver: an update	13
Beyond the tail: the consequence of context in histone post-translational modification and chromatin research	13
Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly	13
The continued evolution of the L2 cephalosporinase in Stenotrophomonas maltophilia: a key driver of beta-lactam resistance	13
Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole	13
TAT–RHIM: a more complex issue than expected	13
Quantitative live-cell imaging of GPCR downstream signaling dynamics	13
Quantifying the long-term interplay between photoprotection and repair mechanisms sustaining photosystem II activity	13
Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation	12
DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability	12
Insights into the mismatch discrimination mechanism of Y-family DNA polymerase Dpo4	12
Syntaxins 6 and 8 facilitate tau into secretory pathways	12
Expression of neuronal NO synthase α- and β-isoforms in skeletal muscle of mice	12
Enhanced plant-microbe remediation of PCBs in soil using enzyme modification technique combined with molecular docking and molecular dynamics	12
Evaluation of artificial signal peptides for secretion of two lysosomal enzymes in CHO cells	12
Abiological catalysis by myoglobin mutant with a genetically incorporated unnatural amino acid	12
Histone deacetylase 7 activates 6-phosphogluconate dehydrogenase via an enzyme-independent mechanism that involves the N-terminal protein-protein interaction domain	12
Mitigating methylglyoxal-induced glycation stress: the protective role of iron, copper, and manganese coordination compounds in Saccharomyces cerevisiae	12
Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis	12
Conformational changes during the reaction cycle of plasma membrane Ca2+-ATPase in the autoinhibited and activated states	12
BACH1, the master regulator of oxidative stress, has a dual effect on CFTR expression	11
A Plasmodium falciparum ubiquitin-specific protease (PfUSP) is essential for parasite survival and its disruption enhances artemisinin efficacy	11
Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells	11
Deubiquitinases in cell death and inflammation	11
From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease	11
An all-out assault on SARS-CoV-2 replication	11
Conformational trapping of an ABC transporter in polymer lipid nanoparticles	11
Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants	11
The atypical thioredoxin ‘Alr2205’, a newly identified partner of the typical 2-Cys-Peroxiredoxin, safeguards the cyanobacterium Anabaena from oxidative stress	10
Identification of ELK1 interacting peptide segments in the androgen receptor	10
Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway	10
Allosteric pluripotency: challenges and opportunities	10
Proximity labelling reveals effects of disease-causing mutation on the DNAJC5/cysteine string protein α interactome	10
Kinases leave their mark on caspase substrates	10
Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling	10
Genetic modulation of CWD prion propagation in cervid PrP Drosophila	10
Proteomic mapping and optogenetic manipulation of membrane contact sites	10

The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress	10
Anti-tumor and anti-metastatic activity of the FGF2 118–126 fragment dependent on the loop structure	10
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses	10
CORM-3 induces DNA damage through Ru(II) binding to DNA	10
TOR complex 2 is a master regulator of plasma membrane homeostasis	10
Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain	9
On the function of TRAP substrate-binding proteins: the isethionate-specific binding protein IseP	9
Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity	9
Histone mimics: more tales to read	9
BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia	9
Dynamic interactions between SPX proteins, the ubiquitination machinery, and signalling molecules for stress adaptation at a whole-plant level	9
Efficient overexpression and purification of severe acute respiratory syndrome coronavirus 2 nucleocapsid proteins in Escherichia coli	9
Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5	9
Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity	9
Improved furfural tolerance in Escherichia coli mediated by heterologous NADH-dependent benzyl alcohol dehydrogenases	9
Interactions of mitochondrial and skeletal muscle biology in mitochondrial myopathy	9
Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel–Lindau syndrome	9
Calcium signalling components underlying NPK homeostasis: potential avenues for exploration	9
Mapping the interaction surface of scorpion β-toxins with an insect sodium channel	9
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase	9
Epigenetic mechanisms linking early-life adversities and mental health	8
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications	8
Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity	8
Protein targeting by the itaconate family in immunity and inflammation	8
Polypharmacological repurposing approach identifies approved drugs as potential inhibitors of Mycobacterium tuberculosis	8
Internalization and membrane activity of the antimicrobial peptide CGA-N12	8
Telomerase RNA evolution: a journey from plant telomeres to broader eukaryotic diversity	8
Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity	8
A global view of the human post-translational modification landscape	8
Mechanistic roles for altered O-GlcNAcylation in neurodegenerative disorders	8
Chaetocin disrupts the SUV39H1–HP1 interaction independent of SUV39H1 methyltransferase activity	8
Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development	8
PHF1 compartmentalizes PRC2 via phase separation	8
Paradigms of receptor kinase signaling in plants	8
Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase	8
The unfolding role of ceramide in coordinating retinoid-based cancer therapy	8
Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate	8
The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms	8
Per aspera ad chaos: a personal journey to the wonderland of intrinsic disorder	8
Macropinocytosis: mechanisms and regulation	8
Expression of Concern: N-terminal chimaeras with signal sequences enhance the functional expression and alter the subcellular localization of heterologous membrane-bound inorganic pyrophosphatases in	8
AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand	8
Understanding amphisomes	8
Serine acetyltransferase from Neisseria gonorrhoeae; structural and biochemical basis of inhibition	8
Role of the leucine-rich repeat protein kinase 2 C-terminal tail in domain cross-talk	7
The genetic and molecular basis of a connexin-linked skin disease	7
Key structural role of a conserved cis-proline revealed by the P285S variant of soybean serine hydroxymethyltransferase 8	7
Protein kinase A and local signaling in cancer	7
The pro-drug C13 activates AMPK by two distinct mechanisms	7
An Arabidopsis thaliana arabinogalactan-protein (AGP31) and several cationic AGP fragments catalyse the boron bridging of rhamnogalacturonan-II	7
Overexpression of phospholipid: diacylglycerol acyltransferase in Brassica napus results in changes in lipid metabolism and oil accumulation	7
The role of mitochondrial RNA association for mitochondrial homeostasis in neurons	7
Incorporation of inosine into DNA by human polymerase eta (Polη): kinetics of nucleotide misincorporation and structural basis for the mutagenicity	7
Microrchidia 2/histone deacetylase 1 complex regulates E-cadherin gene expression and function	7
USP10 deubiquitinates and stabilizes CD44 leading to enhanced breast cancer cell proliferation, stemness and metastasis	7
Sequence variation in the active site of mobile colistin resistance proteins is evolutionarily accommodated through inter-domain interactions	7
Investigating the differential structural organization and gene expression regulatory networks of lamin A Ig fold domain mutants of muscular dystrophy	7
Cancer-associated mutations in protein kinase C theta are loss-of-function	7
Lysine methylation signaling in skeletal muscle biology: from myogenesis to clinical insights	7
Identification and characterization of the Doublesex gene and its mRNA isoforms in the brine shrimp Artemia franciscana	7
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing	7
IL-4 activates the futile triacylglyceride cycle for glucose utilization in white adipocytes	7
Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks	7
Macromolecular crowding and bicarbonate enhance the hydrogen peroxide-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase	7
Activating mutations drive human MEK1 kinase using a gear-shifting mechanism	7
Synthesis, biochemical characterization and in silico investigation of 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid derivatives: dual action mode inhibitors of urease and virulent bacterial	7
The impact of cell states on heterochromatin dynamics	7
The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase	7
Proteotoxic stresses stimulate dissociation of UBL4A from the tail-anchored protein recognition complex	7
Towards ‘end-to-end’ analysis and understanding of biological timecourse data	6
Effect of α-helical domain of Gi/o α subunit on GDP/GTP turnover	6
Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?	6
C-type cytochrome-initiated reduction of bacterial lytic polysaccharide monooxygenases	6
Beyond protein modification: the rise of non-canonical ADP-ribosylation	6
Stress-induced activation of receptor signaling by protease-mediated cleavage	6
Characterization of subunit interactions in the hetero-oligomeric retinoid oxidoreductase complex	6
FATP4 inactivation in cultured macrophages attenuates M1- and ER stress-induced cytokine release via a metabolic shift towards triacylglycerides	6
Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions	6
Aberrant environment and PS-binding to calnuc C-terminal tail drives exosomal packaging and its metastatic ability	6
The complex interplay between autophagy and cell death pathways	6
PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus	6
The C-terminal region of phytoene synthase is a key element to control carotenoid biosynthesis in the haloarchaeon Haloferax volcanii	6
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease	6
No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death	6
SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization	6
A new degree of complexi(n)ty in the regulation of GLUT4 trafficking	6
Conserved L464 in p97 D1–D2 linker is critical for p97 cofactor regulated ATPase activity	6
WHIRLY1 functions in the nucleus to regulate barley leaf development and associated metabolite profiles	6
Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues	6
Flavin oxidation state impacts on nitrofuran antibiotic binding orientation in nitroreductases	6
Importance of tyrosine phosphorylation for transmembrane signaling in plants	6
The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii	6
Co-ordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention	6
Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7	6
Characterization of tolloid-mediated cleavage of the GDF8 procomplex	6