OOIR: Observatory of International Research

Papers

(The TQCC of Biochemical Journal is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Effect of methyl DNA adducts on 3’-5’ exonuclease activity of human TREX1	758
GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration	188
Binding partners regulate unfolding of myosin VI to activate the molecular motor	150
The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications	120
A curated list of targeted optimized promiscuous ketoreductases (TOP-K)	87
PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies	85
Lactate cross-talk in host–pathogen interactions	82
Computational and experimental characterization of the novel ECM glycoprotein SNED1 and prediction of its interactome	76
Kinetics of the multitasking high-affinity Win binding site of WDR5 in restricted and unrestricted conditions	64
Casting iron into the cell fate mold	63
Characterization of the structural determinants of the ubiquitin-dependent proteasomal degradation of human hepatic tryptophan 2,3-dioxygenase	61
Protecting P-type plasma membrane H+-ATPases from ROS	57
Cancer cachexia: molecular mechanism and pharmacological management	54
Insights into the substrate discrimination mechanisms of methyl-CpG-binding domain 4	53
The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors	52
Into the fold: advances in understanding aPKC membrane dynamics	51
AMP-activated protein kinase activation suppresses leptin expression independently of adipogenesis in primary murine adipocytes	51
Elevated atmospheric carbon dioxide and plant immunity to fungal pathogens: do the risks outweigh the benefits?	47
Pseudouridylation-mediated gene expression modulation	47
Ferroptosis in plants: regulation of lipid peroxidation and redox status	47
Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes	47
Frequent loss-of-function mutations in the AMPK-α2 catalytic subunit suggest a tumour suppressor role in human skin cancers	46
Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential	42
Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia	42
Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI	41

Colonic ketogenesis, a microbiota-regulated process, contributes to blood ketones and protects against colitis in mice	41
The PRL2 Phosphatase Upregulates miR-21 through Activation of the JAK2/STAT3 Pathway to Downregulate the PTEN Tumor Suppressor	41
Structural and functional characterization of a mycobacterial methylenetetrahydrofolate reductase utilizing NADH as the exclusive cofactor	40
Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance	40
Mutagenic incorporation of inosine into DNA via T:I mismatch formation by human DNA polymerase eta (polη)	39
Identification of inhibitors of human ChaC1, a cytoplasmic glutathione degrading enzyme through high throughput screens in yeast	39
Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity	38
Aflatoxin biosynthesis regulators AflR and AflS: DNA binding affinity, stoichiometry, and kinetics	38
A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity	37
Abscisic acid triggers vitamin E accumulation by transient transcript activation of VTE5 and VTE6 in sweet cherry fruits	37
Michael D. Waterfield	35
In search for structural targets for engineering d-amino acid transaminase: modulation of pH optimum and substrate specificity	35
Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery	34
Chilling or chemical induction of dormancy release in blackcurrant (Ribes nigrum) buds is associated with characteristic shifts in metabolite profiles	34
Revisiting the roles of cAMP signalling in the progression of prostate cancer	34
Comprehensive comparative assessment of the Arabidopsis thaliana MLO2–CALMODULIN2 interaction by various in vitro and in vivo protein–protein interaction assays	32
Structures of an engineered phospholipase D with specificity for secondary alcohol transphosphatidylation: insights into plasticity of substrate binding and activation	31
PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target	31
RNA processing by the CRISPR-associated NYN ribonuclease	31
Tick–human interactions: from allergic klendusity to the α-Gal syndrome	31
A conserved NAG motif is critical to the catalytic activity of galactinol synthase, a key regulatory enzyme of RFO biosynthesis	30
Higher expression of proline dehydrogenase altered mitochondrial function and increased Trypanosoma cruzi differentiation in vitro and in the insect vector	29
Activation and manipulation of inflammasomes and pyroptosis during bacterial infections	29
Integration of machine learning with computational structural biology of plants	28
Correction: Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity	28
NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes	28
Clathrin: the molecular shape shifter	28
Transforming growth factor-β2-mediated mesenchymal transition in lens epithelial cells is repressed in the absence of RAGE	27
Combinatorial approaches for mitigating resistance to KRAS-targeted therapies	27
Regulation of chromatin accessibility by hypoxia and HIF	27
Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes	26
Conformational plasticity of the ULK3 kinase domain	26
Binding of the Mycobacterium tuberculosis EccCb1 ATPase double hexameric ring to the EsxAB virulence factor is enhanced by ATP	26
Quantitative metabolic fluxes regulated by trans-omic networks	25
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease	25
Respiratory epithelial cell types, states and fates in the era of single-cell RNA-sequencing	24
Translational regulation in pathogenic and beneficial plant–microbe interactions	24
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease	24
Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway	24
Interaction of the periplasmic chaperone SurA with the inner membrane protein secretion (SEC) machinery	24
Diversity of ACE2 and its interaction with SARS-CoV-2 receptor binding domain	23
Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane	22
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells	22
Regulation of Tim-3 function by binding to phosphatidylserine	21
Construction of mouse cochlin mutants with different GAG-binding specificities and their use for immunohistochemistry	21
The optimal pH of AID is skewed from that of its catalytic pocket by DNA-binding residues and surface charge	21
Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin	21
Regulation of B cell receptor signalling by Epstein–Barr virus nuclear antigens	21
Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma	20
Chemical biology tools for protein labelling: insights into cell–cell communication	20

Development of an OTUD1 ubiquitin variant inhibitor	20
Programmed cell death: the pathways to severe COVID-19?	20
Impact of climate perturbations on seeds and seed quality for global agriculture	19
Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2α phosphorylation	19
Vitamin K3 inhibits FtsZ assembly, disrupts the Z-ring in Streptococcus pneumoniae and displays anti-pneumococcal activity	19
No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors	19
Divergent binding mode for a protozoan BRC repeat to RAD51	19
Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression	19
Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth	19
Molecular basis for recognition of the Group A Carbohydrate backbone by the PlyC streptococcal bacteriophage endolysin	18
A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes	18
A home run for human NaCT/SLC13A5/INDY: cryo-EM structure and homology model to predict transport mechanisms, inhibitor interactions and mutational defects	18
The parkinsonism-associated protein FBXO7 cooperates with the BAG6 complex in proteasome function and controls the subcellular localization of the complex	18
Charting the importance of filamin A posttranslational modifications	17
The breakthrough in protein structure prediction	17
LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin	17
Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane	17
Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation	17
Correction: Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signaling	16
Current data processing strategies for cryo-electron tomography and subtomogram averaging	16
Biochemical basis and therapeutic potential of mitochondrial uncoupling in cardiometabolic syndrome	16
The kinetics of islet amyloid polypeptide phase-separated system and hydrogel formation are critically influenced by macromolecular crowding	16
Retraction: MAPK activation by radio waves	16
Tunneling nanotubes and related structures: molecular mechanisms of formation and function	16
Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlierAtITPK4	16
Regulation of PARP1/2 and the tankyrases: emerging parallels	15
Excess iodide-induced reactive oxygen species elicit iodide efflux via β-tubulin-associated ClC-3 in thyrocytes	15
Intelligent host engineering for metabolic flux optimisation in biotechnology	15
Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by down-regulating periostin expression	15
Identification of a 10-mer peptide from the death domain of MyD88 which attenuates inflammation and insulin resistance and improves glucose metabolism	14
Opposing regulation of endoplasmic reticulum retention under stress by ERp44 and PDIA6	14
Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor	14
The biochemistry and physiology of long-chain dicarboxylic acid metabolism	14
In silico, in vitro, and in vivo characterization of thiamin-binding proteins from plant seeds	14
Excitation energy transfer kinetics of trimeric, monomeric and subunit-depleted Photosystem I from Synechocystis PCC 6803	14
Systems approaches to investigate the role of NF-κB signaling in aging	14
Lhs1 dependent ERAD is determined by transmembrane domain context	14
Long-range electron proton coupling in respiratory complex I — insights from molecular simulations of the quinone chamber and antiporter-like subunits	14
A guide to ERK dynamics, part 2: downstream decoding	14
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding	14
GlmS mediated knock-down of a phospholipase expedite alternate pathway to generate phosphocholine required for phosphatidylcholine synthesis in Plasmodium falciparum	14
The C-terminal structure of the N6-methyladenosine deaminase YerA and its role in deamination	14
Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly	13
The continued evolution of the L2 cephalosporinase in Stenotrophomonas maltophilia: a key driver of beta-lactam resistance	13
Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole	13
TAT–RHIM: a more complex issue than expected	13
Quantitative live-cell imaging of GPCR downstream signaling dynamics	13
Quantifying the long-term interplay between photoprotection and repair mechanisms sustaining photosystem II activity	13
Structural and functional organization of germ plasm condensates	13
SREBP-1c and lipogenesis in the liver: an update	13
Beyond the tail: the consequence of context in histone post-translational modification and chromatin research	13
Expression of neuronal NO synthase α- and β-isoforms in skeletal muscle of mice	12
Enhanced plant-microbe remediation of PCBs in soil using enzyme modification technique combined with molecular docking and molecular dynamics	12
Evaluation of artificial signal peptides for secretion of two lysosomal enzymes in CHO cells	12
Abiological catalysis by myoglobin mutant with a genetically incorporated unnatural amino acid	12
Histone deacetylase 7 activates 6-phosphogluconate dehydrogenase via an enzyme-independent mechanism that involves the N-terminal protein-protein interaction domain	12
Mitigating methylglyoxal-induced glycation stress: the protective role of iron, copper, and manganese coordination compounds in Saccharomyces cerevisiae	12
Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis	12
Conformational changes during the reaction cycle of plasma membrane Ca2+-ATPase in the autoinhibited and activated states	12
Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation	12
DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability	12
Insights into the mismatch discrimination mechanism of Y-family DNA polymerase Dpo4	12
Syntaxins 6 and 8 facilitate tau into secretory pathways	12
An all-out assault on SARS-CoV-2 replication	11
Conformational trapping of an ABC transporter in polymer lipid nanoparticles	11
Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants	11
BACH1, the master regulator of oxidative stress, has a dual effect on CFTR expression	11
A Plasmodium falciparum ubiquitin-specific protease (PfUSP) is essential for parasite survival and its disruption enhances artemisinin efficacy	11
Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells	11
Deubiquitinases in cell death and inflammation	11
From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease	11