OOIR: Observatory of International Research

Papers

(The TQCC of Biochemical Journal is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Respiratory epithelial cell types, states and fates in the era of single-cell RNA-sequencing	903
Michael D. Waterfield	213
A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity	201
Identification of inhibitors of human ChaC1, a cytoplasmic glutathione degrading enzyme through high throughput screens in yeast	110
Development of an OTUD1 ubiquitin variant inhibitor	108
Cas11 augments Cascade functions in type I-E CRISPR system but is redundant for gene silencing and plasmid interference	68
GlmS mediated knock-down of a phospholipase expedite alternate pathway to generate phosphocholine required for phosphatidylcholine synthesis in Plasmodium falciparum	67
Combinatorial approaches for mitigating resistance to KRAS-targeted therapies	58
Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method	58
A curated list of targeted optimized promiscuous ketoreductases (TOP-K)	55
In search for structural targets for engineering d-amino acid transaminase: modulation of pH optimum and substrate specificity	53
Aurora A binds to the transactivation domain of c-Myc and recognizes the phosphorylated N-terminal degron motif	53
Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells	52
Mutational insights into human kynurenine aminotransferase 1: modulation of transamination and β-elimination activities across diverse substrates	52
Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor	50
Programmed cell death: the pathways to severe COVID-19?	50
A guide to ERK dynamics, part 2: downstream decoding	50
Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane	50
Improved furfural tolerance in Escherichia coli mediated by heterologous NADH-dependent benzyl alcohol dehydrogenases	49
Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation	48
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses	47
Calcium signalling components underlying NPK homeostasis: potential avenues for exploration	46
Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel–Lindau syndrome	44
Expression of neuronal NO synthase α- and β-isoforms in skeletal muscle of mice	43
BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia	43

The C-terminal structure of the N6-methyladenosine deaminase YerA and its role in deamination	42
The atypical thioredoxin ‘Alr2205’, a newly identified partner of the typical 2-Cys-Peroxiredoxin, safeguards the cyanobacterium Anabaena from oxidative stress	42
Serine acetyltransferase from Neisseria gonorrhoeae; structural and biochemical basis of inhibition	40
A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications	38
TOR complex 2 is a master regulator of plasma membrane homeostasis	37
CORM-3 induces DNA damage through Ru(II) binding to DNA	37
Expression of Concern: Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway	36
The role of mitochondrial RNA association for mitochondrial homeostasis in neurons	35
RhoGAP6 interacts with COPI to regulate protein transport	34
Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues	33
Sequence variation in the active site of mobile colistin resistance proteins is evolutionarily accommodated through inter-domain interactions	32
Towards ‘end-to-end’ analysis and understanding of biological timecourse data	31
Correction: Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity.	31
Proteotoxic stresses stimulate dissociation of UBL4A from the tail-anchored protein recognition complex	30
Lead induces the upregulation of protein arginine methyltransferase 5 possibly by its promoter demethylation	29
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator	29
Interplay of constipation, intestinal barrier dysfunction and fungal exposome in aetiopathogenesis of Parkinson’s disease: hypothesis with supportive data	28
Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?	28
Cryo-EM structure of human MG53 homodimer	27
Identification and characterization of the Doublesex gene and its mRNA isoforms in the brine shrimp Artemia franciscana	25
FoxO transcription factors in mitochondrial homeostasis	25
Characterisation of an influenza B virus-derived peptide presented by HLA-B*18:01	25
Protein kinase A and local signaling in cancer	25
Interactions between insulin and exercise	24
Correction: The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h	24
The uncharacterized protein ZNF200 interacts with PRMT3 and aids its stability and nuclear translocation	24
Structure and function of MDM2 and MDM4 in health and disease	23
Reporter cell lines to screen for inhibitors or regulators of the KRAS-RAF-MEK1/2-ERK1/2 pathway	23
NAD-catabolizing ectoenzymes of Schistosoma mansoni	23
Thermodynamic analysis of Zα domain-nucleic acid interactions	23
Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis	22
Gibberellin-biosynthetic ent-kaurene synthases in higher plants do not require their non-catalytic domains for the catalysis	22
Retraction: Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure	21
GLUT4 On the move	21
Gut reactions and gut instincts: regulation of intestinal homeostasis by receptor guanylyl cyclase C (GC-C)	21
Insight into the function of active site residues in the catalytic mechanism of human ferrochelatase	21
Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling	21
Alphabetti kinase Spaghetti: the complex roles of IKKα and β in the canonical NF-κB pathway	21
Ubiquitin E3 ligases in the plant Arg/N-degron pathway	20
Retraction: Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin	20
Yop1 stability and membrane curvature generation propensity are controlled by its oligomerisation interface	19
Adapting to change: resolving the dynamic and dual roles of NCK1 and NCK2	19
Elevated CO2 alters photosynthesis, growth and susceptibility to powdery mildew of oak seedlings	18
Targeting bacterial degradation machinery as an antibacterial strategy	18
Exopolysaccharide is detrimental for the symbiotic performance of Sinorhizobium fredii HH103 mutants with a truncated lipopolysaccharide core	18
The structure and function of modular Escherichia coli O157:H7 bacteriophage FTBEc1 endolysin, LysT84: defining a new endolysin catalytic subfamily	18
Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2	18
Leukotriene B4 receptor 1 does not mediate disease progression in a mouse model of liver fibrosis	18
IFIT3 (interferon induced protein with tetratricopeptide repeats 3) modulates STAT1 expression in small extracellular vesicles	18
Activity-based probes for dynamic characterisation of polysaccharide-degrading enzymes	17

The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors	17
From the Belousov–Zhabotinsky reaction to biochemical clocks, traveling waves and cell cycle regulation	17
Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system	17
EZH2 promotes chemoresistance in colorectal cancer by inhibiting autophagy through NRP1 suppression	16
Distinct interactors define the p63 transcriptional signature in epithelial development or cancer	16
Comparison of Classical P81 and SVI-P Cation-Exchange Papers in Radiometric Protein Kinase Assays	16
Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity	15
Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth	15
Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding	15
LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin	15
Activation and manipulation of inflammasomes and pyroptosis during bacterial infections	15
The peculiar properties of mitochondrial carriers of the SLC25 family	15
Integrating bacterial molecular genetics with chemical biology for renewed antibacterial drug discovery	15
Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes	15
PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target	15
Abscisic acid triggers vitamin E accumulation by transient transcript activation of VTE5 and VTE6 in sweet cherry fruits	15
Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlierAtITPK4	15
Proteomic mapping and optogenetic manipulation of membrane contact sites	14
DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability	14
Dynamic interchange of local residue–residue interactions in the largely extended single alpha-helix in Drebrin	14
Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity	14
Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5	14
Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain	14
PHF1 compartmentalizes PRC2 via phase separation	14
The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms	14
Kinases leave their mark on caspase substrates	14
Sequence rules for a long SPOP-binding degron required for protein ubiquitylation	14
Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway	14
The impact of cell states on heterochromatin dynamics	13
TAT–RHIM: a more complex issue than expected	13
A Plasmodium falciparum ubiquitin-specific protease (PfUSP) is essential for parasite survival and its disruption enhances artemisinin efficacy	13
Flavin oxidation state impacts on nitrofuran antibiotic binding orientation in nitroreductases	13
Macropinocytosis: mechanisms and regulation	13
Genetic modulation of CWD prion propagation in cervid PrP Drosophila	13
Key structural role of a conserved cis-proline revealed by the P285S variant of soybean serine hydroxymethyltransferase 8	13
Correction: NAD+-consuming enzymes in immune defense against viral infection	13
Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity	13
The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes	12
Synthesis, biochemical characterization and in silico investigation of 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid derivatives: dual action mode inhibitors of urease and virulent bacterial	12
Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases	12
The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase	12
Genome damage accumulated in seed ageing leads to plant genome instability and growth inhibition	11
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing	11
Plant adaptation to climate change	11
The bacterial transcription terminator, Rho, functions as an RNA:DNA hybrid (RDH) helicase in vivo	11
The role of the γ subunit in the photosystem of the lowest-energy phototrophs	11
The C-terminal region of phytoene synthase is a key element to control carotenoid biosynthesis in the haloarchaeon Haloferax volcanii	11
Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2	11
Overexpression of phospholipid: diacylglycerol acyltransferase in Brassica napus results in changes in lipid metabolism and oil accumulation	11
Beyond protein modification: the rise of non-canonical ADP-ribosylation	11
Mechanistic diversity in MHC class I antigen recognition	11
Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation	11
The many ways that nature has exploited the unusual structural and chemical properties of phosphohistidine for use in proteins	10
The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?	10
RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers	10
Characterization of ADAT2/3 molecules in Trypanosoma cruzi and regulation of mucin gene expression by tRNA editing	10
Common and unique features of glycosylation and glycosyltransferases in African trypanosomes	10
Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma	10
ISGylation-independent protection of cell growth by USP18 following interferon stimulation	10
The C-terminal sequences of Bcl-2 family proteins mediate interactions that regulate cell death	10
Development of a colorimetric assay for the detection of SARS-CoV-2 3CLpro activity	10
The monodomain Kunitz protein EgKU-7 from the dog tapeworm Echinococcus granulosus is a high-affinity trypsin inhibitor with two interaction sites	10