Natural Product Reports

Article	Citations
Natural products with atypical atoms: unveiling structures, biosynthetic pathways, and bioactivities	226
Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis	220
Contents list	188
Harnessing microbial co-culture to increase the production of known secondary metabolites	161
The golden decade of eburnamine–vincamine alkaloid synthesis: 2015 to present	116
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	114
Syntheses of furan natural products	113
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	91
Privileged natural product compound classes for anti-inflammatory drug development	82
Medicinal plant resin natural products: structural diversity and biological activities	79
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	79
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	75
Introduction to engineering the biosynthesis of fungal natural products	72
Discovery, bioactivity and biosynthesis of fungal piperazines	66
Inside front cover	64
Streptomyces cell-free systems for natural product discovery and engineering	64
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	63
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	61
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	60
Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products	59
Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering	58
Front cover	57
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	57
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	56
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	56

Charting the path for l -tyrosine derivatives: from engineering strategies to microbial cell factories	56
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	52
Enzymatic ester bond formation strategies in fungal macrolide skeletons	52
Contents list	52
Highlights of cyanobacterial metabolites reported between 2021–2024	51
Inside front cover	51
Marine natural products	49
Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity	47
Streptomyces as a versatile host platform for heterologous production of microbial natural products	47
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	47
Back cover	46
Contents list	45
Editorial: Microbial host and metabolic engineering for natural product discovery and production	44
Biosynthesis of fungal terpenoids	44
Contents list	44
Recent advances in decoding biosynthetic pathways and synthetic biology approaches for plant alkaloids	43
The role of Caenorhabditis elegans in the discovery of natural products for healthy aging	42
Synthetic-bioinformatic natural product-inspired peptides	42
Front cover	42
Inside front cover	41
Inside front cover	40
Contents list	40
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	40
Back cover	39
Front cover	39
Front cover	38
Hot off the Press	38
Front cover	37
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	37
Back cover	36
Natural products modulating interleukin-mediated pathways for anti-allergic and immunomodulatory effects	35
Contents list	35
Technological developments driving industrial natural product discovery	35
Enzymatic crosslinking of histidine side chains in peptide natural products	35
Illuminating the dark space of bioactive peptides with mass spectrometry	34
SAM is not the SAM(e): diastereomers of an important cofactor	34
From gene discovery to synthetic biology: recent advances in the biosynthesis of oleanane-type pentacyclic triterpenoids	34
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	34
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	33
Front cover	32
Brief overview of recently reported misassigned natural products and their in silico revisions enabled by DU8ML, a machine learning-augmented DFT computa	30
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	30
From botanical origins to modern laboratories: 50 year journey in protoberberine alkaloid total synthesis	30
Contents list	29
AI and mechanistic modeling for characterizing biosynthetic pathways of natural products	28
Hot off the Press	28
Back cover	27
Biosynthesis of invertebrate-derived natural products: an uncharted territory	26
Back cover	26
Contents list	26

Engineering the biosynthesis of fungal nonribosomal peptides	26
Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches	26
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	25
Recent advances in the strategic use of multiple enzymatic transformations in the total synthesis of natural products	25
Front cover	25
Recent advances in oxidative phenol coupling for the total synthesis of natural products	25
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	25
Epigenetic regulation of plant specialized metabolism: anthocyanin biosynthesis as a histone acetylation paradigm	25
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	24
The shikimate pathway: gateway to metabolic diversity	24
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	23
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	23
The elansolids: how nature shows chemists how to tame p -quinone methide	23
Semi-synthesis in the exploration of opioid-targeting natural products	23
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	23
Back cover	23
Natural products as anthelmintics: safeguarding animal health	23
Back cover	22
Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis	22
Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	22
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	21
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	21
Asymmetric synthesis of 3,3-disubstituted oxindoles: methodologies and applications in natural product synthesis	21
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	21
Contents list	20
Warfare under the waves: a review of bacteria-derived algaecidal natural products	20
Contents list	20
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	20
High-throughput assays for SAM-dependent methyltransferases: advances, challenges, and future perspectives	19
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	19
Contents list	19
Contents list	19
Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions	19
Hot off the Press	18
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	18
S -Adenosylmethionine: considerations on its role in the origin and evolution of life	18
The chemical and biological properties of natural resorcylic acid lactones	18
The action of phytochemicals in biofilm control	18
Analytical methods for the analysis of volatile natural products	18
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	17
Back cover	17
Intramolecular cycloaddition of nitrones in total synthesis of natural products	17
Contents list	17
Opportunities and challenges of RiPP-based therapeutics	17
A novel class of oligoarylamide antibiotics defined by albicidins and cystobactamids	17
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	17
The development of Burkholderia bacteria as heterologous hosts	17
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin	16
Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer	16
Contents list	16
Volatile organic compounds (VOCs) in terrestrial extreme environments: implications for life detection beyond Earth	16
Back cover	16
Contents list	16
Recent advances in the application of the isoxazoline route to aldols in the synthesis of natural products	15
Inside front cover	15
40 Years of Natural Product Reports	15
Correction: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	15
Contents list	15
Rotenoid diversity, distribution and evolution in plant lineages	15
Inside front cover	14
Structural insights into the diverse prenylating capabilities of DMATS prenyltransferases	14
Radical-mediated cross-linking enzymes in RiPP biosynthesis	14
The bisintercalator family of nonribosomal peptides: structural diversity and biosynthetic mechanism	14
Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers	14
Specialized metabolite modifications in Brassicaceae seeds and plants: diversity, functions and related enzymes	14
Natural product inspired antibiotics approved for human use – 1943 to 2025	13
Recent advances in discovery and biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPP)-derived lipopeptides	13
Contents list	13
Contents list	13
Inhibitors of nutrient pathways: nature's overlooked antibiotic arsenal	13
Contents list	13
Embracing the era of antimicrobial peptides with marine organisms	13
Front cover	13
Back cover	12
Engineering fungal terpene biosynthesis	12
Microbial biotransformation of plant-derived metabolites: mechanisms, pathways, and multi-omics integration	12
Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae)	12
Introduction to volatile natural products	12
Inverse stable isotopic labeling for natural product characterization and discovery	12
Trends in metabolite discovery from Actinomycetes	12

Front cover	11
Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis	11
Unifying ten tryptophan dimer families: linkage diversity from bio-synthetic hypotheses to total synthesis and bioactivity	11
Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria	11
Advances in the discovery and study of Trichoderma natural products for biological control applications	10
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022	10
Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis	10
Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites	9
Meroterpenoids? A historical and critical review of this biogenetic determinant	9
Natural products influence bacteriophage infectivity	9
Engineering class I terpene synthases for skeletal diversity: strategies and applications	9
Back cover	9
Back cover	9
Scaling up for success: from bioactive natural products to new medicines	9
Progress, challenges, and opportunities in the field of biosynthetic reactions involving ambimodal transition states	8
The Kornblum DeLaMare rearrangement in natural product synthesis: 25 years of innovation	8
Chemical diversity of cyanobacterial natural products	8
Chemistry and biology of natural stilbenes: an update	8
Back cover	8
Organic synthesis in the study of terpene-derived oxidation products in the atmosphere	8
Accelerating enzyme discovery and engineering with high-throughput screening	8
Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis	8
SAM-dependent methyltransferases: from chemoenzymatic natural product synthesis to industrial application	8
Hot off the Press	8
Advancing natural product R&D&I: guide for compliance with responsible research and innovation, ethics, Nagoya and Cartagena Protocols, and intellectual property protection	8
Halogenases and dehalogenases: mechanisms, engineering, and applications	7
Back cover	7
Ortho -alkyl phenylalkenoyl natural products: structural diversity, bioactivities and biosynthesis	7
Fe( ii ) and 2-oxoglutarate-dependent dioxygenases for natural product synthesis: molecular insights into reaction diversity	7
Extraction techniques for bioactive compounds of cannabis	7
The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis	7
Inside front cover	7
Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers	7
Scalemic natural products	7
Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ	7
Back cover	6
Hot off the Press	6
Front cover	6
Cultivar to chemotype: characterizing complex botanicals with mass spectrometry metabolomics	6
Back cover	6
S-Adenosylmethionine: more than just a methyl donor	6
Microbial natural products activated by plant stress	6
Back cover	6
Contents list	5
Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies	5
Unveiling Amaryllidaceae alkaloids: from biosynthesis to antiviral potential – a review	5
Cinnamoyl-containing non-ribosomal peptides: discovery, bioactivity and biosynthesis	5
Skeleton innovation versus structural diversification in terpenoid discovery: chemoinformatic insights from TeroKit	5
Huperzine alkaloids: forty years of total syntheses	4
Antarctic bacterial natural products: from genomic insights to drug discovery	4
Hot off the Press	4
Contents list	4
Contents list	4
Front cover	4
Natural ten-membered lactones: sources, structural diversity, biological activity, and intriguing future	4
Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study	4
Verticillins: fungal epipolythiodioxopiperazine alkaloids with chemotherapeutic potential	4
Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri	4
Natural products targeting the metabolism of amino acids: from discovery to synthetic development	4
Back cover	3
para -Quinone methides in natural product biosynthesis	3
Engineering modular enzyme assembly: synthetic interface strategies for natural products biosynthesis applications	3
Contents list	3
Dietary substances and their glucuronides: structures, occurrence and biological activity	3
Isolation and synthesis of bisabosquals, fungal triprenyl phenol meroterpenoids with a densely functionalised bisabolane core	3
Medium-sized peptides from microbial sources with potential for antibacterial drug development	2
Polyamine-containing natural products: structure, bioactivity, and biosynthesis	2
The cytochalasans: potent fungal natural products with application from bench to bedside	2
Diversity of enzymatic SAM-dependent C -methylation of aromatic compounds	2
Structural determination of natural products at speeds and scale of high-throughput screening	2
Chemistry and biology of specialized metabolites produced by Actinomadura	2
Controllable skeletal reorganizations in natural product synthesis	2
Natural products from plants targeting key enzymes for the future development of antidiabetic agents	2
Discovery, structure revision, synthesis, and application of all known and even unknown securingine alkaloids	2
Recent highlights of the total synthesis of cyclic peptide natural products	2
Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics	2
Contents list	2
Plant peptides – redefining an area of ribosomally synthesized and post-translationally modified peptides	2
Unlocking hidden enzymatic chemistry in natural product biosynthesis	2
Challenges in the complexity-to-diversity strategy for natural product-like compound synthesis: two sides of the same coin	2
Visual cycle-derived bisretinoids as endogenous natural products: enzyme-free formation, photochemical reactivity, and retinal degeneration	2
Back cover	2
Back cover	2
Microbial skeletal editing: hints for arene reconstruction from actinobacteria	2