Natural Product Reports

Article	Citations
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	196
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	165
Harnessing microbial co-culture to increase the production of known secondary metabolites	122
Privileged natural product compound classes for anti-inflammatory drug development	120
Silybin and its congeners: from traditional medicine to molecular effects	101
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	96
Biosynthesis, regulation, and engineering of natural products from Lysobacter	95
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	93
Front cover	91
Back cover	77
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	75
Discovery, bioactivity and biosynthesis of fungal piperazines	74
Inside front cover	74
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	71
Medicinal plant resin natural products: structural diversity and biological activities	69
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	66
Introduction to engineering the biosynthesis of fungal natural products	65
Streptomyces cell-free systems for natural product discovery and engineering	61
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	61
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	60
Front cover	56
Enzymatic ester bond formation strategies in fungal macrolide skeletons	56
Inside front cover	56
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	55
Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity	54

Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	53
Correction: Dearomative logic in natural product total synthesis	52
Chemoenzymatic approaches to plant natural product inspired compounds	52
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	49
Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis	47
Marine natural products	46
Contents list	46
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	46
Front cover	46
Contents list	43
Contents list	42
Back cover	42
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	41
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	41
Synthetic-bioinformatic natural product-inspired peptides	41
Image to insight: exploring natural products through mass spectrometry imaging	40
Biosynthesis of fungal terpenoids	40
Contents list	38
Hot off the Press	38
Front cover	38
Front cover	37
Illuminating the dark space of bioactive peptides with mass spectrometry	36
Strategies for the synthesis ofStemonaalkaloids: an update	36
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	36
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	35
Enzymatic crosslinking of histidine side chains in peptide natural products	35
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	33
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	33
Contents list	31
Back cover	31
Back cover	31
Back cover	30
Inside front cover	30
Chemistry and biosynthesis of bacterial polycyclic xanthone natural products	29
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	29
Synthesis of rearranged indole diterpenes of the paxilline type	29
Recent advances in oxidative phenol coupling for the total synthesis of natural products	29
Hot off the Press	29
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	28
Natural product-based PROteolysis TArgeting Chimeras (PROTACs)	28
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	28
Back cover	28
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	28
Engineering the biosynthesis of fungal nonribosomal peptides	28
The shikimate pathway: gateway to metabolic diversity	28
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	27
Contents list	27
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	27
Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	27
Natural products as anthelmintics: safeguarding animal health	27

Back cover	26
Strategies for total synthesis of bispyrrolidinoindoline alkaloids	26
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	25
Front cover	25
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	25
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	25
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	25
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	25
Contents list	24
Back cover	24
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	23
Contents list	23
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	23
Warfare under the waves: a review of bacteria-derived algaecidal natural products	22
Analytical methods for the analysis of volatile natural products	22
Biosynthesis and bioactivities of microbial genotoxin colibactins	22
Contents list	22
Opportunities and challenges of RiPP-based therapeutics	21
The action of phytochemicals in biofilm control	21
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	21
Intramolecular cycloaddition of nitrones in total synthesis of natural products	21
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	21
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	21
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin	20
Back cover	20
Egg toxic compounds in the animal kingdom. A comprehensive review	20
Back cover	20
Contents list	20
Contents list	20
Contents list	20
Front cover	20
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	19
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes	19
Specialized metabolite modifications in Brassicaceae seeds and plants: diversity, functions and related enzymes	18
Correction: Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	18
Discovery and development of botanical natural products and their analogues as therapeutics for ovarian cancer	18
Contents list	18
The bisintercalator family of nonribosomal peptides: structural diversity and biosynthetic mechanism	17
40 Years of Natural Product Reports	17
Volatile organic compounds (VOCs) in terrestrial extreme environments: implications for life detection beyond Earth	17
Back cover	16
Challenges and opportunities for cheat therapy in the control of bacterial infections	16
Contents list	16
Structural insights into the diverse prenylating capabilities of DMATS prenyltransferases	16
The ins and outs of transporters at plasma membrane and tonoplast in plant specialized metabolism	16
Front cover	16
Recent advances in the application of the isoxazoline route to aldols in the synthesis of natural products	16
Contents list	15
Back cover	15
Engineering fungal terpene biosynthesis	14
Introduction to volatile natural products	14
Inside front cover	14
Correction: Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids	14
Contents list	14
Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis	14
Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria	14
Picrotoxane sesquiterpenoids: chemistry, chemo- and bio-syntheses and biological activities	13
Embracing the era of antimicrobial peptides with marine organisms	13
Biosynthesis of pyrroloindoline-containing natural products	13
Anthracyclines: biosynthesis, engineering and clinical applications	13
Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis	12
Chemistry and bioactivity of lindenane sesquiterpenoids and their oligomers	12
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022	12
Back cover	12
Back cover	11
Bioactive natural products from Bacteroidetes	11
Organic synthesis in the study of terpene-derived oxidation products in the atmosphere	11
Back cover	11
Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives	11
Chemistry and biology of natural stilbenes: an update	11
The Kornblum DeLaMare rearrangement in natural product synthesis: 25 years of innovation	11
Chemical diversity of cyanobacterial natural products	10
Meroterpenoids? A historical and critical review of this biogenetic determinant	10
Scaling up for success: from bioactive natural products to new medicines	10
Extraction techniques for bioactive compounds of cannabis	10
Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners	10
Comparing total chemical synthesis and total biosynthesis routes to fungal specialized metabolites	10
Accelerating enzyme discovery and engineering with high-throughput screening	10
Scalemic natural products	9
Inside front cover	9

Fe(ii) and 2-oxoglutarate-dependent dioxygenases for natural product synthesis: molecular insights into reaction diversity	9
Back cover	9
Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature	9
Unpacking policy developments in marine natural product research: a scientist's guide to DSI and BBNJ	9
Front cover	9
Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers	8
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design	8
The fungal natural product class of the sorbicillinoids: structures, bioactivities, biosynthesis, and synthesis	8
Euphorbiaditerpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)	8
Microbial polyketides and their roles in insect virulence: from genomics to biological functions	8
Contents list	7
Hot off the Press	7
Verticillins: fungal epipolythiodioxopiperazine alkaloids with chemotherapeutic potential	7
Unveiling Amaryllidaceae alkaloids: from biosynthesis to antiviral potential – a review	7
Contents list	7
Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study	7
The phosphate ester group in secondary metabolites	7
S-Adenosylmethionine: more than just a methyl donor	7
Hot off the Press	7
Natural ten-membered lactones: sources, structural diversity, biological activity, and intriguing future	7
Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies	7
Antarctic bacterial natural products: from genomic insights to drug discovery	6
Huperzine alkaloids: forty years of total syntheses	6
Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri	6
Medium-sized peptides from microbial sources with potential for antibacterial drug development	6
Recent advances in the synthesis of ent-kaurane diterpenoids	6
Plant-based engineering for production of high-valued natural products	6
Front cover	6
Chemical synthesis in competition with global genome mining and heterologous expression for the preparation of dimeric tryptophan-derived 2,5-dioxopiperazines	6
Integrative omics approaches for biosynthetic pathway discovery in plants	6
Contents list	6
Anti-mycobacterial natural products and mechanisms of action	5
Plant peptides – redefining an area of ribosomally synthesized and post-translationally modified peptides	5
Natural products from plants targeting key enzymes for the future development of antidiabetic agents	5
Controllable skeletal reorganizations in natural product synthesis	5
The cytochalasans: potent fungal natural products with application from bench to bedside	5
Back cover	5
Harnessing intercellular signals to engineer the soil microbiome	5
Alternative metabolic pathways and strategies to high-titre terpenoid production inEscherichia coli	5
Polyamine-containing natural products: structure, bioactivity, and biosynthesis	5
Back cover	4
Back cover	4
Front cover	4
Front cover	4
Chemistry and biology of specialized metabolites produced by Actinomadura	4
Describing the complex chemistry of benthic seawater: from exometabolite sampling strategies to MS-based metabolomics	4
Recent highlights of the total synthesis of cyclic peptide natural products	4
Back cover	4
Hot off the press	4
Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae	4
Promoter engineering of natural product biosynthetic gene clusters in actinomycetes: concepts and applications	3
Regulation of daptomycin biosynthesis in Streptomyces roseosporus: new insights from genomic analysis and synthetic biology to accelerate lipopeptide discovery and commercial production	3
Contents list	3
Hot off the Press	3
Contents list	3
Empowering natural product science with AI: leveraging multimodal data and knowledge graphs	3
Hot off the Press	3
Back cover	3
Ring systems in natural products: structural diversity, physicochemical properties, and coverage by synthetic compounds	2
Hot off the Press	2
On the evolution of coenzyme biosynthesis	2
Unleashing the potential: type I CRISPR-Cas systems in actinomycetes for genome editing	2
Harmonizing biosynthesis with post-ingestive modifications to understand the ecological functions of plant natural products	2
Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi	2
Gold-catalyzed cyclization and cycloaddition in natural product synthesis	2
Contents list	2
A straightforward access to trifluoromethylated natural products through late-stage functionalization	2
Natural sesquiterpene quinone/quinols: chemistry, biological activity, and synthesis	2
The biosynthetic logic and enzymatic machinery of approved fungi-derived pharmaceuticals and agricultural biopesticides	2
Corallopyronin A: antimicrobial discovery to preclinical development	2
Front cover	2
Back cover	2
Back cover	2