OOIR: Observatory of International Research

Papers

(The TQCC of Natural Product Reports is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
New developments in RiPP discovery, enzymology and engineering	419
Marine natural products	246
Marine natural products	148
The scaffold-forming steps of plant alkaloid biosynthesis	98
Natural products in agarwood andAquilariaplants: chemistry, biological activities and biosynthesis	96
Cytochrome P450 enzymes in fungal natural product biosynthesis	93
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	86
A roadmap for metagenomic enzyme discovery	83
Marine natural products	83
Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches	82
Bacterial terpenome	79
Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities	75
Triptolide: reflections on two decades of research and prospects for the future	73
Traditional Chinese medicine (TCM) as a source of new anticancer drugs	71
Genome mining methods to discover bioactive natural products	62
Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities	61
Terpenoids from the medicinal mushroomAntrodia camphorata: chemistry and medicinal potential	61
Structure, synthesis, biosynthesis, and activity of the characteristic compounds fromGinkgo bilobaL.	59
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	59
Mind the mushroom: natural product biosynthetic genes and enzymes of Basidiomycota	58
Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy	57
Phytostilbenes as agrochemicals: biosynthesis, bioactivity, metabolic engineering and biotechnology	57
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	56
Machine learning approaches for elucidating the biological effects of natural products	55
Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits	51

Microbial natural product databases: moving forward in the multi-omics era	51
Enzymatic dimerization in the biosynthetic pathway of microbial natural products	49
Metabolomics and complementary techniques to investigate the plant phytochemical cosmos	49
Regio- and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis	48
Solanum steroidal glycoalkaloids: structural diversity, biological activities, and biosynthesis	48
Recent advances in the biosynthesis strategies of nitrogen heterocyclic natural products	48
Anthracyclines: biosynthesis, engineering and clinical applications	47
The year 2020 in natural product bioinformatics: an overview of the latest tools and databases	45
The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs	45
Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis	44
How different are marine microbial natural products compared to their terrestrial counterparts?	42
Chemistry of fungal meroterpenoid cyclases	41
Biosynthesis of azaphilones: a review	41
Biosynthesis, evolution and ecology of microbial terpenoids	41
Fungal–fungal co-culture: a primer for generating chemical diversity	40
Advancements in capturing and mining mass spectrometry data are transforming natural products research	40
Alternative metabolic pathways and strategies to high-titre terpenoid production inEscherichia coli	40
Unlocking the potential of marine biodiscovery	39
Natural product C-glycosyltransferases – a scarcely characterised enzymatic activity with biotechnological potential	39
Sesterterpenoids: chemistry, biology, and biosynthesis	38
Research progress of meliaceous limonoids from 2011 to 2021	38
Skipped dienes in natural product synthesis	35
Naturally occurring prenylated chalcones from plants: structural diversity, distribution, activities and biosynthesis	35
Tropane alkaloid biosynthesis: a centennial review	34
Biosynthesis of cyclopropane in natural products	34
Pitfalls in the structural elucidation of small molecules. A critical analysis of a decade of structural misassignments of marine natural products	34
Marine paralytic shellfish toxins: chemical properties, mode of action, newer analogues, and structure–toxicity relationship	34
Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded inStreptomycesgenomes	33
Multi-colored shades of betalains: recent advances in betacyanin chemistry	33
Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria	32
Structure–function relationship of terpenoid glycosyltransferases from plants	32
Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)	32
Bottromycins - biosynthesis, synthesis and activity	32
The untapped potential of plant sesterterpenoids: chemistry, biological activities and biosynthesis	31
Euphorbiaditerpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)	31
MicroED in natural product and small molecule research	31
The application potential of machine learning and genomics for understanding natural product diversity, chemistry, and therapeutic translatability	31
Cytotoxic and antitumor peptides as novel chemotherapeutics	31
The chemical ecology of the fungus-farming termite symbiosis	30
The chemistry and biology of guanidine secondary metabolites	30
The confluence of big data and evolutionary genome mining for the discovery of natural products	30
Rocaglamide and silvestrol: a long story from anti-tumor to anti-coronavirus compounds	29
Recent advances in the synthesis of ent-kaurane diterpenoids	29
The beauty of biocatalysis: sustainable synthesis of ingredients in cosmetics	28
Large-scale culture as a complementary and practical method for discovering natural products with novel skeletons	28
The synthesis of biologically active indolocarbazole natural products	27
Natural withanolides, an update	27
Ribosomally synthesized peptides, foreground players in microbial interactions: recent developments and unanswered questions	27
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	27
Natural products as modulators of retinoic acid receptor-related orphan receptors (RORs)	26

Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis	26
Dearomative logic in natural product total synthesis	26
Biosynthesis of pyrroloindoline-containing natural products	26
N,C-Coupled naphthylisoquinoline alkaloids: a versatile new class of axially chiral natural products	26
Cheminformatic analysis of natural product-based drugs and chemical probes	26
Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity	26
Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases	24
Plant biosynthetic gene clusters in the context of metabolic evolution	24
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	23
Balancing skeleton and functional groups in total syntheses of complex natural products: a case study of tigliane, daphnane and ingenane diterpenoids	23
Image to insight: exploring natural products through mass spectrometry imaging	23
Silybin and its congeners: from traditional medicine to molecular effects	23
Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining	23
Biosynthesis and heterologous production of furanocoumarins: perspectives and current challenges	23
Ring systems in natural products: structural diversity, physicochemical properties, and coverage by synthetic compounds	23
Molecules derived from the extremes of life: a decade later	22
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design	22
Polypharmacology of andrographolide: beyond one molecule one target	22
Polyketide β-branching: diversity, mechanism and selectivity	22
Selaginellins from the genusSelaginella: isolation, structure, biological activity, and synthesis	21
Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature	21
Integrative omics approaches for biosynthetic pathway discovery in plants	21
Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi	20
Artificial intelligence in microbial natural product drug discovery: current and emerging role	20
The isolation of water-soluble natural products – challenges, strategies and perspectives	20
Predicting biochemical and physiological effects of natural products from molecular structures using machine learning	19
Biosynthesis of quinolizidine alkaloids in lupins: mechanistic considerations and prospects for pathway elucidation	19
Anthraquinone-fused enediynes: discovery, biosynthesis and development	19
Norditerpenoid alkaloids from Aconitum and Delphinium: structural relevance in medicine, toxicology, and metabolism	19
Chemical labeling strategies for small molecule natural product detection and isolation	18
Structural diversity, biosynthesis, and biological functions of lipopeptides fromStreptomyces	18
Biosynthetic strategies for tetramic acid formation	18
Structural diversity and biological relevance of benzenoid and atypical ansamycins and their congeners	18
Site-directed mutagenesis and substrate compatibility to reveal the structure–function relationships of plant oxidosqualene cyclases	17
Cis double bond formation in polyketide biosynthesis	17
Engineering the biosynthesis of fungal nonribosomal peptides	17
Cryptic halogenation reactions in natural product biosynthesis	17
Bioactive natural products from Bacteroidetes	17
The need to innovate sample collection and library generation in microbial drug discovery: a focus on academia	17