OOIR: Observatory of International Research

Papers

(The TQCC of Natural Product Reports is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	196
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	165
Harnessing microbial co-culture to increase the production of known secondary metabolites	122
Privileged natural product compound classes for anti-inflammatory drug development	120
Silybin and its congeners: from traditional medicine to molecular effects	101
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis	96
Biosynthesis, regulation, and engineering of natural products from Lysobacter	95
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	93
Front cover	91
Back cover	77
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	75
Inside front cover	74
Discovery, bioactivity and biosynthesis of fungal piperazines	74
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	71
Medicinal plant resin natural products: structural diversity and biological activities	69
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	66
Introduction to engineering the biosynthesis of fungal natural products	65
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	61
Streptomyces cell-free systems for natural product discovery and engineering	61
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	60
Inside front cover	56
Front cover	56
Enzymatic ester bond formation strategies in fungal macrolide skeletons	56
Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	55
Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity	54

Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	53
Chemoenzymatic approaches to plant natural product inspired compounds	52
Correction: Dearomative logic in natural product total synthesis	52
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	49
Non-peptide secondary metabolites from poisonous mushrooms: overview of chemistry, bioactivity, and biosynthesis	47
Front cover	46
Marine natural products	46
Contents list	46
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	46
Contents list	43
Back cover	42
Contents list	42
Synthetic-bioinformatic natural product-inspired peptides	41
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	41
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	41
Biosynthesis of fungal terpenoids	40
Image to insight: exploring natural products through mass spectrometry imaging	40
Front cover	38
Contents list	38
Hot off the Press	38
Front cover	37
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	36
Illuminating the dark space of bioactive peptides with mass spectrometry	36
Strategies for the synthesis ofStemonaalkaloids: an update	36
Enzymatic crosslinking of histidine side chains in peptide natural products	35
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	35
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	33
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	33
Back cover	31
Back cover	31
Contents list	31
Inside front cover	30
Back cover	30
Recent advances in oxidative phenol coupling for the total synthesis of natural products	29
Hot off the Press	29
Chemistry and biosynthesis of bacterial polycyclic xanthone natural products	29
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	29
Synthesis of rearranged indole diterpenes of the paxilline type	29
Engineering the biosynthesis of fungal nonribosomal peptides	28
The shikimate pathway: gateway to metabolic diversity	28
Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis	28
Natural product-based PROteolysis TArgeting Chimeras (PROTACs)	28
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	28
Back cover	28
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	28
Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	27
Natural products as anthelmintics: safeguarding animal health	27
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	27
Contents list	27
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	27

Strategies for total synthesis of bispyrrolidinoindoline alkaloids	26
Back cover	26
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	25
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	25
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	25
Front cover	25
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	25
A critical review on the use of DP4+ in the structural elucidation of natural products: the good, the bad and the ugly. A practical guide	25
Contents list	24
Back cover	24
Contents list	23
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	23
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	23
Warfare under the waves: a review of bacteria-derived algaecidal natural products	22
Analytical methods for the analysis of volatile natural products	22
Biosynthesis and bioactivities of microbial genotoxin colibactins	22
Contents list	22
Opportunities and challenges of RiPP-based therapeutics	21
The action of phytochemicals in biofilm control	21
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	21
Intramolecular cycloaddition of nitrones in total synthesis of natural products	21
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	21
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	21
Recent insights into the biosynthesis and biological activities of the peptide-derived redox cofactor mycofactocin	20
Back cover	20
Egg toxic compounds in the animal kingdom. A comprehensive review	20
Back cover	20
Contents list	20
Contents list	20
Contents list	20
Front cover	20
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic	19
Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes	19