OOIR: Observatory of International Research

Papers

(The TQCC of Natural Product Reports is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Privileged natural product compound classes for anti-inflammatory drug development	209
Recent advances in the synthesis of insect pheromones: an overview from 2013 to 2022	201
The molecular complexity of terpene biosynthesis in red algae: current state and future perspectives	152
Syntheses of furan natural products	142
Ryanodane diterpenes: occurrence, structural diversity, bioactivities, and synthesis	109
Estimating the extent of adulteration of the popular herbs black cohosh, echinacea, elder berry, ginkgo, and turmeric – its challenges and limitations	103
Harnessing microbial co-culture to increase the production of known secondary metabolites	97
Inside front cover	80
Photo-/electro-chemical catalysis: a promising toolkit for late-stage functionalization of alkene-containing natural products	72
The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide	70
Discovery, bioactivity and biosynthesis of fungal piperazines	67
Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis	64
Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease	61
Medicinal plant resin natural products: structural diversity and biological activities	59
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology	59
Introduction to engineering the biosynthesis of fungal natural products	57
Streptomyces cell-free systems for natural product discovery and engineering	55
Front cover	52
Recent advances in the biosynthetic studies of bacterial organoarsenic natural products	52
Inside front cover	51
Natural nematicidal metabolites and advances in their biocontrol capacity on plant parasitic nematodes	49
Contents list	49
Charting the path for l -tyrosine derivatives: from engineering strategies to microbial cell factories	49
Highlights of cyanobacterial metabolites reported between 2021–2024	48
Prenylated bacterial natural products: occurrence, chemical diversity, biosynthesis and bioactivity	47

Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?	47
Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids	46
Marine natural products	44
Maleidride biosynthesis – construction of dimeric anhydrides – more than just heads or tails	44
Toward a unified pipeline for natural product discovery: tools and strategies for NRPS and PKS pathway exploration and engineering	43
Enzymatic ester bond formation strategies in fungal macrolide skeletons	43
Streptomyces as a versatile host platform for heterologous production of microbial natural products	43
Front cover	41
Back cover	41
Contents list	41
Inside front cover	40
Synthetic-bioinformatic natural product-inspired peptides	40
Contents list	40
Inside front cover	40
Editorial: Microbial host and metabolic engineering for natural product discovery and production	39
Front cover	39
The role ofCaenorhabditis elegansin the discovery of natural products for healthy aging	38
Biosynthesis of fungal terpenoids	38
Subterranean marvels: microbial communities in caves and underground mines and their promise for natural product discovery	36
Front cover	35
Front cover	35
Front cover	34
Technological developments driving industrial natural product discovery	34
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides	34
Enzymatic crosslinking of histidine side chains in peptide natural products	34
Illuminating the dark space of bioactive peptides with mass spectrometry	34
Back cover	33
Back cover	33
Hot off the Press	32
Brief overview of recently reported misassigned natural products and their in silico revisions enabled by DU8ML, a machine learning-augmented DFT computa	32
Back cover	31
[2 + 2]-Cycloaddition-derived cyclobutane natural products: structural diversity, sources, bioactivities, and biomimetic syntheses	31
Advances in the total synthesis of bis- and tris-indole alkaloids containing N-heterocyclic linker moieties	31
Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals	31
Natural products modulating interleukin-mediated pathways for anti-allergic and immunomodulatory effects	31
Contents list	30
Hot off the Press	29
Back cover	28
Contents list	27
Metabolism and bioavailability aspects of natural products of plant origin using mass spectrometry-based and metabolomic approaches	26
Front cover	25
Biosynthesis of indole diterpenes: a reconstitution approach in a heterologous host	25
AI and mechanistic modeling for characterizing biosynthetic pathways of natural products	25
Recent advances in oxidative phenol coupling for the total synthesis of natural products	24
Biosynthesis of invertebrate-derived natural products: an uncharted territory	24
Chemistry, biosynthesis and biology of floral volatiles: roles in pollination and other functions	24
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis	24
The shikimate pathway: gateway to metabolic diversity	23
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant systems	23
Engineering the biosynthesis of fungal nonribosomal peptides	23

Microbial engineering for natural and unnatural glycosaminoglycans biosynthesis	23
Back cover	23
Semi-synthesis in the exploration of opioid-targeting natural products	23
Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming	22
Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours	22
Modular polyketide synthase-derived insecticidal agents: from biosynthesis and metabolic engineering to combinatorial biosynthesis for their production	21
Bacterial cyclophane-containing RiPPs from radical SAM enzymes	21
Anthrol reductases: discovery, role in biosynthesis and applications in natural product syntheses	21
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products	21
Contents list	20
Natural products as anthelmintics: safeguarding animal health	20
Contents list	20
Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis	19
Analytical methods for the analysis of volatile natural products	19
Contents list	19
Unlocking marine treasures: isolation and mining strategies of natural products from sponge-associated bacteria	19
The action of phytochemicals in biofilm control	19
Therapeutic vulnerabilities of cancer stem cells and effects of natural products	18
Contents list	18
Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids	18
Hot off the Press	18
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products	18
The chemical and biological properties of natural resorcylic acid lactones	17
Unlocking the metabolic potential of endophytic fungi through epigenetics: a paradigm shift for natural product discovery and plant–microbe interactions	17
Opportunities and challenges of RiPP-based therapeutics	17
Warfare under the waves: a review of bacteria-derived algaecidal natural products	17
S -Adenosylmethionine: considerations on its role in the origin and evolution of life	17
Contents list	16
Contents list	16
Back cover	16
Contents list	16