BioEssays

Article	Citations
Spatially Resolved Transcriptomes—Next Generation Tools for Tissue Exploration	329
Adapting with Microbial Help: Microbiome Flexibility Facilitates Rapid Responses to Environmental Change	150
DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis	89
Emerging High‐Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X)	81
Crosstalk between Cell Adhesion Complexes in Regulation of Mechanotransduction	65
The genetic structure of SARS‐CoV‐2 does not rule out a laboratory origin	63
Mechanical and Non‐Mechanical Functions of Filamentous and Non‐Filamentous Vimentin	55
Beta‐Adrenergic Blockers as a Potential Treatment for COVID‐19 Patients	51
Cancer as a prospective sequela of long COVID‐19	50
Interoception and the origin of feelings: A new synthesis	48
From structure to function: Route to understanding lncRNA mechanism	48
Monitoring Autophagy Flux and Activity: Principles and Applications	46
Paraspeckle nuclear condensates: Global sensors of cell stress?	45
Superposition of COVID‐19 waves, anticipating a sustained wave, and lessons for the future	41
Bridging the explanatory gaps: What can we learn from a biological agency perspective?	39
Trehalose against Alzheimer's Disease: Insights into a Potential Therapy	39
Cancer progression as a sequence of atavistic reversions	39
mTORC1 and ferroptosis: Regulatory mechanisms and therapeutic potential	37
Present‐Day DNA Contamination in Ancient DNA Datasets	33
Ubiquitin‐Modulated Phase Separation of Shuttle Proteins: Does Condensate Formation Promote Protein Degradation?	33
DNA adenine methylation in eukaryotes: Enzymatic mark or a form of DNA damage?	33
Noncanonical functions of the serine‐arginine‐rich splicing factor (SR) family of proteins in development and disease	33
Scale‐Free Biology: Integrating Evolutionary and Developmental Thinking	32
Reconciling the seemingly irreconcilable: The WHO's ICF system integrates biological and psychosocial environmental determinants of autism and ADHD	32
Age and Location in Severity of COVID‐19 Pathology: Do Lactoferrin and Pneumococcal Vaccination Explain Low Infant Mortality and Regional Differences?	32

Accounting for variation in and overuse of antibiotics among humans	30
BRD4 in physiology and pathology: ‘‘BET’’ on its partners	29
Latest Advances for the Sleeping Beauty Transposon System: 23 Years of Insomnia but Prettier than Ever	29
Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment	28
Neuronal Compartmentalization: A Means to Integrate Sensory Input at the Earliest Stage of Information Processing?	27
Single cell RNA‐sequencing: A powerful yet still challenging technology to study cellular heterogeneity	27
Transmissible cancers in mammals and bivalves: How many examples are there?	27
Lifespan Extension Via Dietary Restriction: Time to Reconsider the Evolutionary Mechanisms?	27
Temperature‐Dependent Sex Determination in Sea Turtles in the Context of Climate Change: Uncovering the Adaptive Significance	27
How everyday sounds can trigger strong emotions: ASMR, misophonia and the feeling of wellbeing	26
A second Warburg‐like effect in cancer metabolism: The metabolic shift of glutamine‐derived nitrogen	25
Tumor necrosis: A synergistic consequence of metabolic stress and inflammation	25
Metabolomics meets lipidomics: Assessing the small molecule component of metabolism	24
Introducing the 21st Century's New Four Horsemen of the Coronapocalypse	23
Pushing Raman spectroscopy over the edge: purported signatures of organic molecules in fossil animals are instrumental artefacts	23
Phage lysis‐lysogeny switches and programmed cell death: Danse macabre	23
Epigenetic editing: Dissecting chromatin function in context	22
Genetic Causation in Complex Regulatory Systems: An Integrative Dynamic Perspective	22
CRISPR/Cas technology as a promising weapon to combat viral infections	21
Might SARS‐CoV‐2 Have Arisen via Serial Passage through an Animal Host or Cell Culture?	21
Competitive and Coordinative Interactions between Body Parts Produce Adaptive Developmental Outcomes	21
Strangers look sicker (with implications in times of COVID‐19)	21
Positive allometry of sexually selected traits: Do metabolic maintenance costs play an important role?	21
Polycomb Repressive Complexes in Hox Gene Regulation: Silencing and Beyond	21
How to become a crab: Phenotypic constraints on a recurring body plan	20
Evolution of Sex Determination and Sex Chromosomes: A Novel Alternative Paradigm	20
Host under epigenetic control: A novel perspective on the interaction between microorganisms and corals	19
Microscopy‐based assay for semi‐quantitative detection of SARS‐CoV‐2 specific antibodies in human sera	19
Neural stem cell pools in the vertebrate adult brain: Homeostasis from cell‐autonomous decisions or community rules?	19
Methods for enzyme library creation: Which one will you choose?	19
How potassium came to be the dominant biological cation: of metabolism, chemiosmosis, and cation selectivity since the beginnings of life	19
Ocean carbon sequestration: Particle fragmentation by copepods as a significant unrecognised factor?	18
Prime editing in plants and mammalian cells: Mechanism, achievements, limitations, and future prospects	18
RNA‐protein interactions: Central players in coordination of regulatory networks	18
Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities, and pathophysiological functions	18
How immune‐cell fate and function are determined by metabolic pathway choice	18
Processed pseudogenes: A substrate for evolutionary innovation	18
SARS‐CoV‐2 infection and cancer	17
How does early‐life adversity shape telomere dynamics during adulthood? Problems and paradigms	17
Gene mutations impede oocyte maturation, fertilization, and early embryonic development	17
Brain wiring with composite instructions	17
The chaperone Clusterin in neurodegeneration−friend or foe?	17
Evolution of Sex Determination in Amniotes: Did Stress and Sequential Hermaphroditism Produce Environmental Determination?	16
Dimensional reduction in complex living systems: Where, why, and how	16
The enigmatic Placozoa part 1: Exploring evolutionary controversies and poor ecological knowledge	16
Speculating on the Roles of Nuclear Speckles: How RNA‐Protein Nuclear Assemblies Affect Gene Expression	16
SNP‐based heritability and selection analyses: Improved models and new results	15
Chromatin behavior in living cells: Lessons from single‐nucleosome imaging and tracking	15
Degeneracy in the nervous system: from neuronal excitability to neural coding	15
GWAS for genetics of complex quantitative traits: Genome to pangenome and SNPs to SVs and k‐mers	15

Rebuilding relationships on coral reefs: Coral bleaching knowledge‐sharing to aid adaptation planning for reef users	15
The fine‐tuning of cell membrane lipid bilayers accentuates their compositional complexity	15
COVID‐19 coagulopathies: Human blood proteins mimic SARS‐CoV‐2 virus, vaccine proteins and bacterial co‐infections inducing autoimmunity	15
The HPA Axis under Stress and Aging: Individual Vulnerability is Associated with Behavioral Patterns and Exposure Time	15
SARS‐CoV‐2′s claimed natural origin is undermined by issues with genome sequences of its relative strains	15
Small mitochondrial RNAs as mediators of nuclear gene regulation, and potential implications for human health	14
Revisiting poly(A)‐binding proteins: Multifaceted regulators during gametogenesis and early embryogenesis	14
Circalunar clocks—Old experiments for a new era	14
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases	14
CRISPR/Cas9: A new tool for the study and control of helminth parasites	14
Soft repression: Subtle transcriptional regulation with global impact	13
The solid tumor microenvironment—Breaking the barrier for T cells	13
TRPV4: A trigger of pathological RhoA activation in neurological disease	13
Beyond genotype‐phenotype maps: Toward a phenotype‐centered perspective on evolution	13
Biodynamic Interfaces Are Essential for Human–Environment Interactions	13
Managing enzyme promiscuity in plant specialized metabolism: A lesson from flavonoid biosynthesis	13
Bone regeneration via skeletal cell lineage plasticity: All hands mobilized for emergencies	13
Designer nanoparticles for plant cell culture systems: Mechanisms of elicitation and harnessing of specialized metabolites	13
Physiological mediators of prenatal environmental influences in autism spectrum disorder	13
Males can adjust offspring sex ratio in an adaptive fashion through different mechanisms	13
Cancer's second genome: Microbial cancer diagnostics and redefining clonal evolution as a multispecies process	13
Metabolic Reprogramming is a Hallmark of Metabolism Itself	12
Did doubly uniparental inheritance (DUI) of mtDNA originate as a cytoplasmic male sterility (CMS) system?	12
The complex web of canonical and non‐canonical Hedgehog signaling	12
The SARS‐CoV‐2 origin dilemma: Zoonotic transfer or laboratory leak?	12
Is mitochondrial reactive oxygen species production proportional to oxygen consumption? A theoretical consideration	12
Mammalian D‐cysteine: A novel regulator of neural progenitor cell proliferation	12
Eggshell Biliverdin as an Antioxidant Maternal Effect	12
Structural Basis of Nucleosome Recognition and Modulation	12
Paneth cells: Maintaining dynamic microbiome‐host homeostasis, protecting against inflammation and cancer	11
The promises of lysine polyphosphorylation as a regulatory modification in mammals are tempered by conceptual and technical challenges	11
The CAR group of Ig cell adhesion proteins–Regulators of gap junctions?	11
Solving the conundrum of intra‐specific variation in metabolic rate: A multidisciplinary conceptual and methodological toolkit	11
The Fluidity of the Bacterial Outer Membrane Is Species Specific	11
Challenging endings: How telomeres prevent fragility	11
Fine‐tuning ER‐phagy by post‐translational modifications	11
“Minimal metabolism”: A key concept to investigate the origins and nature of biological systems	11
Can BCG vaccine protect against COVID‐19 via trained immunity and tolerogenesis?	11
Air pollution and cardiovascular disease: Can the Australian bushfires and global COVID‐19 pandemic of 2020 convince us to change our ways?	11
Metabolism and chromatin: A dynamic duo that regulates development and ageing	11
Endothelial ontogeny and the establishment of vascular heterogeneity	11
The glow of the night: The tapetum lucidum as a co‐adaptation for the inverted retina	10
Trade‐offs between the instantaneous growth rate and long‐term fitness: Consequences for microbial physiology and predictive computational models	10
Endolysosomal cholesterol export: More than just NPC1	10
How do boreal forest soils store carbon?	10
Taming fitness: Organism‐environment interdependencies preclude long‐term fitness forecasting	10
Afadin (AF6) in cancer progression: A multidomain scaffold protein with complex and contradictory roles	10
The molecular tug of war between immunity and fertility: Emergence of conserved signaling pathways and regulatory mechanisms	10
The gamma‐tubulin ring complex: Deciphering the molecular organization and assembly mechanism of a major vertebrate microtubule nucleator	10
Post‐translational Wnt receptor regulation: Is the fog slowly clearing?	10
Reactive oxygen species (ROS) constitute an additional player in regulating epithelial development	10
Tissue‐disruption‐induced cellular stochasticity and epigenetic drift: Common origins of aging and cancer?	10
Structural basis of the conformational and functional regulation of human SERCA2b, the ubiquitous endoplasmic reticulum calcium pump	10
Cas9 Cuts and Consequences; Detecting, Predicting, and Mitigating CRISPR/Cas9 On‐ and Off‐Target Damage	10
NIPSNAP protein family emerges as a sensor of mitochondrial health	10
Cross‐Generational Effects of Parental Age on Offspring Longevity: Are Telomeres an Important Underlying Mechanism?	10
The cell cycle and differentiation as integrated processes: Cyclins and CDKs reciprocally regulate Sox and Notch to balance stem cell maintenance	10
Global climate change, diet, and the complex relationship between human host and microbiome: Towards an integrated picture	9
Rho GTPases: Non‐canonical regulation by cysteine oxidation	9
Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling	9
The PINK1 repertoire: Not just a one trick pony	9
Evaluation of 92 cardiovascular proteins in dried blood spots collected under field‐conditions	9
The strange case of Drp1 in autophagy: Jekyll and Hyde?	9
New tools suggest a middle Jurassic origin for mammalian endothermy	9
How does the early life environment influence the oral microbiome and determine oral health outcomes in childhood?	9
No neonates without adults	9
MiRNAs in early brain development and pediatric cancer	9
Switching DCAFs: Beyond substrate receptors	9
CBC‐Clock Theory of Life – Integration of cellular circadian clocks and cellular sentience is essential for cognitive basis of life	9
Modeling the evolution of interconnected processes: It is the song and the singers	9
Molecular dynamics studies reveal structural and functional features of the SARS‐CoV‐2 spike protein	9
Why do cancer cells break from host circadian rhythm? Insights from unicellular organisms	9
Collective cell migration driven by filopodia—New insights from the social behavior of myotubes	9
Lipophilic Environmental Chemical Mixtures Released During Weight‐Loss: The Need to Consider Dynamics	9
Population modification strategies for malaria vector control are uniquely resilient to observed levels of gene drive resistance alleles	9
Why the Outcome of Anti‐Tumor Immune Responses is Heterogeneous: A Novel Idea in the Context of Immunological Heterogeneity in Cancers	9
Tolerogenic and immunogenic states of Langerhans cells are orchestrated by epidermal signals acting on a core maturation gene module	9
Genotoxic stress response: What is the role of cytoplasmic mRNA fate?	9
The Sexual Ancestor of all Eukaryotes: A Defense of the “Meiosis Toolkit”	8
Raman spectroscopy is a powerful tool in molecular paleobiology: An analytical response to Alleon et al. (https://doi.org/10.1002/bies.202000295)	8

The cap epitranscriptome: Early directions to a complex life as mRNA	8
Inheritance and maintenance of small RNA‐mediated epigenetic effects	8
Active genetics comes alive	8
CHRONOCRISIS: When Cell Cycle Asynchrony Generates DNA Damage in Polyploid Cells	8
Cancer and the breakdown of multicellularity: What Dictyostelium discoideum, a social amoeba, can teach us	8
Desynchronized circadian clock and exposures to xenobiotics are associated with differentiated disease phenotypes	8
Estrogen receptor α revised: Expression, structure, function, and stability	8
Do microenvironmental changes disrupt multicellular organisation with ageing, enacting and favouring the cancer cell phenotype?	8
Do some viruses use growth hormone, prolactin and their receptors to facilitate entry into cells?	8
Epigenetic rejuvenation by partial reprogramming	8
BTB domains: A structural view of evolution, multimerization, and protein–protein interactions	8
Perirhinal cortex area 35 controls the functional link between the perirhinal and entorhinal‐hippocampal circuitry	8
Apoptotic mitochondrial poration by a growing list of pore‐forming BCL‐2 family proteins	8
Skipping sex: A nonrecombinant genomic assemblage of complementary reproductive modules	8
Environmental Oxygen is a Key Modulator of Development and Evolution: From Molecules to Ecology	8
Big Baby, Little Mother: Tsetse Flies Are Exceptions to the Juvenile Small Size Principle	8
The tyranny of phylogeny—A plea for a less dogmatic stance on two‐species comparisons	8
The tree of life describes a tripartite cellular world	8
Rebirth of the translational machinery: The importance of recycling ribosomes	8
Importin α/β and the tug of war to keep TDP‐43 in solution: quo vadis?	8
Ribosomal protein uS3 in cell biology and human disease: Latest insights and prospects	7
MicroRNAs play regulatory roles in genomic balance	7
Broad H3K4me3 domains: Maintaining cellular identity and their implication in super‐enhancer hijacking	7
Does transcriptional heterogeneity facilitate the development of genetic drug resistance?	7
Neuron‐glia crosstalk in neuronal remodeling and degeneration: Neuronal signals inducing glial cell phagocytic transformation in Drosophila	7
Personalized health and the coronavirus vaccines—Do individual genetics matter?	7
Predatory Preprint Servers Join Predatory Journals in the Paper Mill Industry…	7
Teeth reveal juvenile diet, health and neurotoxicant exposure retrospectively: What biological rhythms and chemical records tell us	7
Do seasonal microbiome changes affect infection susceptibility, contributing to seasonal disease outbreaks?	7
Beyond the GTP‐cap: Elucidating the molecular mechanisms of microtubule catastrophe	7
Liquid–liquid phase separation drives the β‐catenin destruction complex formation	7
Sorting of cargo in the tubular endosomal network	7
Skin aging: Dermal adipocytes metabolically reprogram dermal fibroblasts	7
Molecules interact. But how strong and how much?	7
Co‐translational folding of nascent polypeptides: Multi‐layered mechanisms for the efficient biogenesis of functional proteins	7
Concerted evolution of ribosomal DNA: Somatic peace amid germinal strife	7
Longitudinal observations call into question the scientific consensus that humans are unaffected by lunar cycles	7
Copulation Song in Drosophila: Do Females Sing to Change Male Ejaculate Allocation and Incite Postcopulatory Mate Choice?	7
Minichromosome maintenance proteins in eukaryotic chromosome segregation	7
Biological sex is binary, even though there is a rainbow of sex roles	7
Meiosis I Kinase Regulators: Conserved Orchestrators of Reductional Chromosome Segregation	7
SAC during early cell divisions: Sacrificing fidelity over timely division, regulated differently across organisms	7
Nucleosomes and flipons exchange energy to alter chromatin conformation, the readout of genomic information, and cell fate	6
Foraminifera as a model of the extensive variability in genome dynamics among eukaryotes	6
Assay technologies facilitating drug discovery for ADP‐ribosyl writers, readers and erasers	6
Embryonic movement stimulates joint formation and development: Implications in arthrogryposis multiplex congenita	6
Unexpected new insights into DNA clamp loaders	6
Flipping and other astonishing transporter dance moves in fungal drug resistance	6
Keeping the balance: The noncoding RNA 7SK as a master regulator for neuron development and function	6
Modulation of H3.3 chromatin assembly by PML: A way to regulate epigenetic inheritance	6
Potential of the CRISPR‐Cas system for improved parasite diagnosis	6
Synaptic Pruning in Schizophrenia: Does Minocycline Modulate Psychosocial Brain Development?	6
Function moves biomolecular condensates in phase space	6
The XK plasma membrane scramblase and the VPS13A cytosolic lipid transporter for ATP‐induced cell death	6
Mitochondrially localized MPZL3 emerges as a signaling hub of mammalian physiology	6
Why does COVID‐19 pathology have several clinical forms?	6
Regulation and function of poised mRNAs in lymphocytes	6
Using primary teeth and archived dried spots for exposomic studies in children: Exploring new paths in the environmental epidemiology of pediatric cancer	6
Flagellar export apparatus and ATP synthetase: Homology evidenced by synteny predating the Last Universal Common Ancestor	6
Distinguishing serial homologs from novel traits: Experimental limitations and ideas for improvements	6
Similarities in the induction of the intracellular pathogen response in Caenorhabditis elegans and the type I interferon response in mammals	6
Bayes and Darwin: How replicator populations implement Bayesian computations	6
KCTD10 Biology: An Adaptor for the Ubiquitin E3 Complex Meets Multiple Substrates	6
There is no evidence of SARS‐CoV‐2 laboratory origin: Response to Segreto and Deigin (DOI: 10.1002/bies.202000240)	6
Models for human porphyrias: Have animals in the wild been overlooked?	6
Anillin: The First Proofreading‐like Scaffold?	6
Evolutionary context can clarify gene names: Teleosts as a case study	6
Can natural selection and druggable targets synergize? Of nutrient scarcity, cancer, and the evolution of cooperation	6
Are Anaphase Events Really Irreversible? The Endmost Stages of Cell Division and the Paradox of the DNA Double‐Strand Break Repair	6
GC‐content biases in protein‐coding genes act as an “mRNA identity” feature for nuclear export	6
The circle of Willis revisited: Forebrain dehydration sensing facilitated by the anterior communicating artery	6