OOIR: Observatory of International Research

Papers

(The median citation count of Biomedical Chromatography is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
	39
	32
Issue Information	31
Characterization and Analytical Method Validation for Potential Impurities of a Merchantability Drug Substance Fluoxetine HCl	31
Pioneering Human Plasma Detection of Haloperidol With 5‐pg/mL Sensitivity via Refined Sample Preparation and Advanced LC–MS/MS	28
Preparation of 5‐hydroxymethylfurfural from Schisandra chinensis (Turcz.) Baill by high‐speed counter‐current chromatography: Comparison of conventional and consecutive separation	28
Development of stability‐indicating method for separation and characterization of benidipine forced degradation products using LC–MS/MS	27
Development of simultaneous quantitative analytical method for metabolites of hexosamine biosynthesis pathway in lung cancer cells using ultra‐high‐performance liquid chromatography‐tandem mass spectr	25
A new method for detecting Na⁺, K⁺‐ATPase activity by ICP–MS: Quantitative analysis on the inhibitory effect of rhein on Na⁺, K⁺‐ATPase activity by ICP–MS i	24
A novel UPLC–MS/MS method for simultaneous quantification of trigonelline, 4‐hydroxyisoleucine, and diosgenin from Trigonella foenum‐graecum extract: Application to pharmacokinetic s	22
Lipidomics reveals the serum profiles of pediatric allergic rhinitis and its severity	20
The pharmacokinetics and tissue distribution of curcumin following inhalation administration in rats—A comparative analysis with oral and intravenous routes	20
In vivo detection of the epimer metabolites of sweroside via ultra‐performance liquid chromatography time‐of‐flight mass spectrometry combined with DNPH derivatization	20
Dissipation pattern and dietary risk assessment of some commonly used insecticides on tomato (Solanum lycopersicum L.)	19
Evaluation of various polysaccharide‐based stationary phases for enantioseparation of chloro‐containing derivatives in normal phase liquid chromatography	19
Residue levels and risk assessment of acetamiprid–pyridaben mixtures in cabbage under various open field conditions	18
Development of a simultaneous quantification method of imatinib and sunitinib and their main metabolites and its application in patients with gastrointestinal stromal tumor	18
Matrix effect in bioanalytical assay development using supercritical fluid chromatography‐mass spectrometry	18
Detection and identification of imperatorin metabolites in rat, dog, monkey, and human liver microsomes by ultra‐high‐performance liquid chromatography combined with high‐resolution mass spectrometry	16
An UHPLC–QTOF–MS‐based strategy for systematic profiling of chemical constituents and associated in vivo metabolites of a famous traditional Chinese medicine formula, Yinchenhao decoction	16
Development of an efficient stability‐indicating LC–MS/MS method for the analysis of selexipag and characterization of its degradation products	16
Mango peel extracts and mangiferin chromatographic Fourier‐transform infrared correlation with antioxidant, antidiabetic, and advanced glycation end product inhibitory potentials using in silico model	16
Issue Information	15
RP‐HPLC method development, validation and pharmacokinetic applicability in preclinical evaluation of rhein treated with novel diacerein eutectics	15
Issue Information	15

Multimodal Metabolomics Analysis Reveals That Classic Decoction Mitigates Myocardial Ischemia‐Induced Damage by Modulating Energy and Branched‐Chain Amino Acid Metabolism	15
Issue Information	15
Review of HPLC–MS methods for the analysis of nicotine and its active metabolite cotinine in various biological matrices	14
Characterization and traceability of two generations of standard reference material for the measurement of vitamin K₁(phylloquinone) at endogenous concentrations in human plasma and serum	14
Online preconcentration and determination of five alkaloids in Yangxinshi tablet by large‐volume sample stacking and micelle to solvent stacking in cyclodextrin‐modified electrokinetic chromatography	13
Comparative phytochemical study of methanolic and ethanolic extracts of Thymus linearis and their antibacterial and antioxidant potential	13
Chromatographic analysis and antioxidant potency of the crude extract of Xanthium spinosum in various fractions	13
Development and validation of gas chromatography with electron capture detection method using QuEChERS for pesticide residue determination in cucumber	13
Evaluation of lipophilicity and drug‐likeness of donepezil‐like compounds using reversed‐phase thin‐layer chromatography	13
Development of a joint derivatization protocol for the unequivocal identification of the monosaccharide composition in four dendrobium polysaccharides and free monosaccharide by GC–MS	13
Spectroscopic characterization and pharmacokinetic evaluation of amorphous solid dispersions of glibenclamide for bioavailability enhancement in Wistar rats	12
Development and validation of a stability‐indicating ultra‐high‐performance liquid chromatography method for the estimation of ibrutinib and trace‐level quantification of related substances using qual	12
Determination of three C18‐oxygenated steroids in adrenal lesion segments in primary aldosteronism by super‐selective adrenal venous sampling and LC/ESI–MS/MS	12
Insight gained via ultra‐performance liquid chromatography tandem mass spectrometry‐based metabolomics: Protective effect of Artemisia argyi H.Lév. & Vaniot essential oil on lipopolysacchar	12
Potential role of the methanolic extract for Olea europaea (stem and leaves) on sporulation of Eimeria papillata oocysts: In vitro study	12
Investigation of the therapeutic effect of Hedan tablets on high‐fat diet‐induced obesity in rats by GC–MS technology and 16S ribosomal RNA gene sequencing	12
Screening for α‐glucosidase inhibitors from Selaginella uncinata based on the ligand fishing combined with ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight–tandem m	11
Therapeutic potential of Shaoyao Gancao Decoction in mitigating anti‐tuberculosis drug‐induced liver injury through Nrf‐2/HO‐1/NF‐κB signaling	11
Characteristic profiling of Aconiti Lateralis Radix for distinguishing it from compatible herbal pair using UPLC–Q‐TOF–MS coupled with chemometrics	11
Simultaneous determination of monocrotaline and its N‐oxide metabolite in rat plasma using LC–MS/MS: Application to a pharmacokinetic study	11
Delineation of prototypical degradation mechanism, characterization of unknown degradation impurities by liquid chromatography–quadrupole‐time‐of‐flight–tandem mass spectrometry and stability‐indicati	10
Investigating the in vivo effect of Tribulus terrestris extract in middle cerebral artery occlusion rats using LC–MS‐based metabolomics combined with molecular docking	10
LC–MS/MS method for determination of kansuinine a in rat plasma and its application to a rat pharmacokinetic study	10
Hybrid solid‐phase extraction to overcome interference due to phospholipids for determination of neratinib in human plasma using UPLC–MS/MS	10
Pharmacokinetic and pharmacodynamic herb–drug interactions of common over‐the‐counter pain medications	10
Process Optimization of Stir‐Fried Inonotus hispidus Based on the Box–Behnken Design‐Response Surface Method and the Component Variations During the Stir‐Frying Process	10
Simultaneous quantitation of urine aldosterone and tetrahydroaldosterone in healthy Chinese subjects using a validated LC–MS/MS method	10
Systematic analysis of chemical profiles of Sophorae tonkinensis Radix et Rhizoma in vitro and in vivo using UPLC‐Q‐TOF‐MS^E	10
The impact of insecticides containing deltamethrin and cyfluthrin on the composition of surface compounds in the larvae, females and males of Tenebrio molitor	10
Development and validation of novel RP‐HPLC method for midostaurin determination using analytical quality by design approach from regulatory perspective and determination of major degradation compound	10
Comparative analysis of the liver‐protective effects of raw and stir‐fried semen of Hovenia dulcis in rats via gas chromatography–mass spectrometry–based serum metabolomic profiling	10
Effect of concomitant oral administration of ethanol on the pharmacokinetics of nicardipine in rats	10
Favipiravir (SARS‐CoV‐2) degradation impurities: Identification and route of degradation mechanism in the finished solid dosage form using LC/LC–MS method	10
A pharmacokinetics interaction study of antiplatelet agents aspirin and clopidogrel combined with dl‐3‐n‐butylphthalide in rats by liquid chromatography–tandem mass spectrometry	10
A liquid chromatography–tandem mass spectrometry method development for the quantification of favipiravir drug and its related impurities in rat plasma and its application to pharmacokinetic studies	9
Spectrum–effect relationship between HPLC fingerprint and hypoglycemic of litchi leaves (Litchi chinensis Sonn) in vitro	9
	9
Supercritical fluid chromatography for milligram preparation of enantiomers	9
Si Miao San relieves hyperuricemia by regulating intestinal flora	9
An LC–ESI–MS/MS assay for the therapeutic drug monitoring of 15 antiseizure medications in plasma of children with epilepsy	9
Serum metabolome analysis reveals medicinal fungi Phellinus igniarius ameliorated type 2 diabetes mellitus indications in rats via modulation of amino acid and carbohydrate metabolism	9
	9
Serum and urine metabolomics based on UPLC–QTOF/MS reveal the effect and potential mechanism of “schisandra–evodia” herb pair in the treatment of Alzheimer's disease	9
Pharmacokinetic and metabolism study of ginsenoside Rb2 in rat by liquid chromatography combined with electrospray ionization tandem mass spectrometry	9
	9
A Simple Rapid HPLC‐UV Method for Assessing C‐Terminal Arginine Content in Darbepoetin Alfa	9
Supported liquid extraction combined with liquid chromatography tandem mass spectrometry for the quantitative analysis of a TLR7 agonist imiquimod LFX453 in plasma at low picograms per milliliter: Met	9
Determination of Schaftoside and Isoschaftoside in Rat Plasma Utilizing UPLC‐MS/MS	8
Farfarae Flos Mitigates Cigarette Smoking‐Induced Lung Inflammation by Regulating the Lysophosphatidylcholine Biosynthesis and Tryptophan Metabolism	8
The Continued Mismeasurement of Plasma Serotonin: A Systematic Review	8

Identifying of Anticoagulant Ingredients From Moutan Cortex Based on Spectrum‐Effect Relationship Analysis Combined With GRA, PLS, and SVM Algorithms	8
Metabolomic comparison between natural Huaier and artificial cultured Huaier	8
Metabolomic analysis of amino acids and organic acids in aging mouse eyes using gas chromatography–tandem mass spectrometry	8
Profiling of widely targeted metabolomics for the identification of chemical composition in epidermis, xylem and pith of Gleditsiae Spina	8
Assessment of remdesivir and its nucleoside metabolite in beagle dogs and healthy humans by liquid chromatography coupled with triple quadrupole mass spectrometry	8
Comparative Chromatographic Analysis of Amino Acids in the Seeds of Three Nigella L. Representatives	8
Metabolite Identification of Huangqi Guizhi Wuwu Granules in Rat Urine and Feces Based on Ultra–High‐Performance Liquid Chromatography With Quadrupole Time‐of‐Flight Mass Spectrometry	8
	8
Determination of 59 Psychotropic Drugs, Including Antipsychotics, Antidepressants, Antiepileptics, Anti‐Alcohol Abuse Drugs, Anti‐ADHD Drugs, and Their Metabolites in Urine Using LC–MS/MS for Medicati	8
LC–MS/MS method for quick detection of vonoprazan fumarate in human plasma: Development, validation and its application to a bioequivalence study	8
UPLC Estimate of Sofosbuvir and Ledipasvir Utilizing Greenness Tool in Conjunction With an Analytical Quality by Design	8
	8
Widely Targeted Metabolomics Reveals the Bioactive Metabolites and Antioxidant Activities of Chinese Yam (Dioscorea opposita Thunb.) Peel	8
Lipidomics reveals the dysregulated ceramide metabolism in oxidized low‐density lipoprotein‐induced macrophage‐derived foam cell	7
The delivery of nanoparticles improves the pharmacokinetic properties of celecoxib to open a therapeutic window for oral administration of insoluble drugs	7
Phytochemical profile and pharmacological potential of Withania somnifera whole plant extracts	7
Pharmacokinetic and metabolic profiling studies of osmundacetone in rats by UPLC–MS/MS and UPLC–QE–Orbitrap–HRMS	7
Innovative UPLC technique for concurrent quantification of etofenamate and benzyl nicotinate in the presence of methylparaben and benzyl alcohol in their topical cream: Greens, white, and Six Sigma me	7
A novel method for purification of biologically active C‐terminal fragment of human recombinant anti‐mullerian hormone	7
In vitro wound healing properties, antioxidant activities, HPLC–ESI–MS/MS profile and phytoconstituents of the stem aqueous methanolic extract of Dracaena reflexa Lam	7
Green method by National Environmental Methods Index and Eco‐Scale Assessment for evaluation of gatifloxacin‐based product by HPLC	7
A selective, sensitive and fast LC–MS/MS method for cabotegravir quantification in rat plasma and pharmacokinetic investigations	7
An effective LC–MS method for the simultaneous determination of a potential anti‐rheumatoid arthritis drug, carboxyamidotriazole, and its major metabolite in rat plasma	7
Human plasma ricinine quantification by LC–HRMS after micro‐solid‐phase elution	7
HPLC–PDA identification and resolution of rufinamide forced degradation impurities: A congregated chemometric expedite optimization coupled with factorials and desirability	7
LC‐HRMS‐based targeted metabolomics for high‐throughput and quantitative analysis of 21 growth inhibition‐related metabolites in Chinese hamster ovary cell fed‐batch cultures	7
A fluorinated chitosan‐based QuEChERS method for simultaneous determination of 20 organophosphorus pesticide residues in ginseng using GC–MS/MS	7
Quantification of serum thyroid hormones using tandem mass spectrometry in patients with Down syndrome	7
Quantitation of tazemetostat in human plasma using liquid chromatography–tandem mass spectrometry	7
Metabolic characteristics and pharmacokinetic differences of Qiwei Tongbi oral liquid in rheumatoid arthritis rats	7
	6
A simple, high‐throughput and validated LC–MS/MS method for the determination of azithromycin in human plasma and its application to a clinical pharmacokinetic study	6
Network pharmacology study on fermented soybeans for the prevention of Alzheimer's disease in older individuals	6
Featured Cover	6
Screening and characterization of cosmetic efficacy components of Terminalia chebula based on biological activity‐guided methodology	6
Metabolomic analysis of the sera of patients with the long‐term inhalation of caffeine‐sodium benzoate using LC–MS	6
Revealing the mechanism of Gualou–Xiebai against myocardial ischemia based on network pharmacology and energy metabolism strategies	6
Adipo‐specific chemerin knockout alters the metabolomic profile of adipose tissue under normal and high‐fat diet conditions: Application of an untargeted liquid chromatography–tandem mass spectrometry	6
Simultaneous quantification of icaritin and its novel 3‐methylcarbamate prodrug in rat plasma using HPLC–MS/MS and its application to pharmacokinetic study	6
Noval Selective Ligand‐Extraction of Bioactive Components in Complex Natural Products Applying Immobilized Multi‐Target Magnetic Beads	6
Simultaneous determination of 3‐n‐butylphthalide and its metabolite 10‐hydroxy‐butylphthalide in rat plasma using liquid chromatography–tandem mass spectrometry and application to a pharmacokin	6
Issue Information	6
Quantitation of plasma angiotensin II in healthy Chinese subjects by a validated liquid chromatography tandem mass spectrometry method	6
Metabolomics and serum pharmacochemistry revealed the preventive mechanism of Gushudan in kidney‐yang‐deficiency‐syndrome rats	6
Impact of introducing a new biological matrix into a validated bioanalytical method: Focus on matrix protein content	6
Study on the material basis of Zhujing pill in treating fundus lesions through component analysis and network pharmacology	6
Protective effects of Typhonii Rhizoma in rheumatoid arthritis rats revealed by integrated metabolomics and network pharmacology	6
Comparative analysis of six aconitine‐type alkaloids in decocting extracts between the different processed Fuzi (Aconiti Lateralis Radix praeparata) and its pharmacokinetic behavior in rats by HPLC‐MS	6
Synthesis, characterization and control of eight process‐related and two genotoxic fingolimod impurities by a validated RP‐UPLC method	6
Comparative analysis of bioactive constituents and pharmacological activities from different parts of Nauclea officinalis	6
Simultaneous Quantification of Filgotinib and Its Active Metabolite in Human Plasma Using Liquid Chromatography–Tandem Mass Spectrometry: Validation and Clinical Application	6
A validated stability‐indicating reversed‐phase‐UPLC method for simultaneous estimation of promethazine hydrochloride, methylparaben, propylparaben and sodium benzoate assay of cough suppressant and a	6
	6
Investigation of the Potential Material Basis and Mechanism of Astragali Radix Against Adriamycin‐Induced Nephropathy Model Rat by ¹H NMR and MS‐Based Untargeted Metabolomics Analysis	6
Developing LC–MS/MS methods to quantify rivaroxabanin human plasma and urine: Application to therapeutic drug monitoring	6
A Simple, Sensitive, and Stable LC–MS/MS Method for the Simultaneous Determination and Pharmacokinetic Study of Dapagliflozin and Its Metabolite D3OG in Human Plasma	6
Spectrum‐Effect Relationship Between Fingerprints and Anti‐Inflammatory and Antitussive Activities of Raw and Processed Mume Fructus Extracts	6
Spectrum–effect relationship study between ultra‐high‐performance liquid chromatography fingerprints and anti‐hepatoma effect in vitro of Cnidii Fructus	6
A novel LC–MS/MS approach to [¹⁹F]‐alfatide and alfatide for application in preclinical pharmacokinetics	6
Identification of the metabolites of nimbolide in rat by liquid chromatography combined with quadrupole/orbitrap mass spectrometry	6
Dispersive liquid–liquid microextraction and Monte Carlo simulation of margin of safety for octocrylene, EHMC, 2ES, and homosalate in sunscreens	6
Enantioselective determination of phenthoate enantiomers in plant‐origin matrices using reversed‐phase high‐performance liquid chromatography–tandem mass spectrometry	6
A Simple and Sensitive LC‐MS/MS Method for the Determination of Mobocertinib and Its Metabolite Desmethyl‐Mobocertinib in Human Plasma and Its Application to Clinical Pharmacokinetic Study	6
Chemical characterization, multivariate analysis and comparison of biological activities of different parts of Fraxinus mandshurica	6
	6
A validated stability‐indicating reversed‐phase‐HPLC method for dipyridamole in the presence of degradation products and its process‐related impurities in pharmaceutical dosage forms	5
Mechanisms exploration of terrestrosin D on pulmonary fibrosis based on plasma metabolomics and network pharmacology	5
Metabolic profiling of emodin drug‐induced liver injury and silybin treatment in rats using ultra‐performance liquid chromatography‐quadrupole‐time‐of‐flight‐mass spectrometry: A metabolomic and mecha	5
Non‐Targeted Metabolomics Analysis of Metabolite Differences in Inocutis tamaricis Under Different Culture Conditions	5
LC–HRMS methods for the quantification of two artemisinin drugs and their metabolites in rat blood and plasma	5
Biosynthesized silver nanoparticle–coated electro‐membrane extraction of perchlorate in different seafood samples	5
Preparation of amentoflavone‐loaded DSPE‐PEG₂₀₀₀ micelles with improved bioavailability and in vitro antitumor efficacy	5
A robust, accurate, sensitive LC–MS/MS method to measure indoxyl sulfate, validated for plasma and kidney cells	5
In vivo and in vitro chemical composition and biological activity of traditional vs. dispensing granule decoctions of Coptidis Rhizoma: A comparative study	5
Bioanalytical Tandem Mass Spectrometry Method for Precise Measurement of Tranexamic Acid in Human Plasma With Unveiling Methodological Advancement: Green Assessment With Advanced Metrics	5
Trace‐level determination of potential genotoxic impurities in quetiapine fumarate using LC–MS	5
Determination of the dissipative behaviour and final residue of sodium nitrophenol in jujube by liquid chromatography–tandem mass spectrometry	5
Fluorescent immunochromatography of vancomycin in plasma: A rapid and sensitive quantitative analysis	5
Highly sensitive liquid chromatography–mass spectrometry method for the quantitative analysis of mometasone furoate in human plasma: Method validation and application to clinical pharmacokinetic studi	5
Rapid analysis of components in Qizhiweitong tablets and plasma after oral administration in rats by UPLC–Q‐TOF–MS/MS based on a self‐developed database	5

Mechanism of Jinteng Qingbi granules in the treatment of rheumatoid arthritis using metabolomics analysis	5
Metabolomics study of the hepatoprotective effect of total flavonoids of Mallotus apelta leaf in carbon tetrachloride‐induced liver fibrosis in rats	5
Development, evaluation of critical method variables and stability assessment using a Box–Behnken design for the determination of organic impurities in a pharmaceutical dosage form of a centrally acti	5
Degradation pathways and impurity profiling of the anticancer drug apalutamide by HPLC and LC–MS/MS and separation of impurities using Design of Experiments	5
Anti‐rheumatoid arthritis effects of Xanthii Fructus by affecting the PI3K‐AKT signaling pathway based on TMT‐labeled quantitative proteomics	5
Preparation, characterization, and pharmacokinetics of oridonin‐loaded liposomes	5
Jiedu Tongluo Tiaogan Formula Modulates Glycolipid Metabolism in Type 2 Diabetes via Pyroptosis: Network Pharmacology and In Vivo Analysis	5
Nano‐LC: An updated review	5
A novel standard‐free detection of adulteration method for sildenafil derivatives in dietary supplements	5
A simple and sensitive liquid chromatography triple quadrupole mass spectrometry method for the determination of XL092 in monkey plasma and its application to pharmacokinetic study	5
Integrated pharmacokinetics of Huangqi Jianzhong Tang in normal and chronic atrophic gastritis rats	5
Metabolism of four novel structural analogs of ketamine, 2‐FXE [2‐(ethylamino)‐2‐(2‐fluorophenyl) cyclohexan‐1‐one], 2‐MDCK [2‐(methylamino)‐2‐(o‐tolyl) cyclohexan‐1‐one], 3‐DMXE [2‐(ethylamino	5
Elucidating the mechanisms underlying the anti‐hyperlipidemic effects of Laportea bulbifera using integrated serum metabolomics and network pharmacology	5
Bone and periosteum protein analysis via tandem mass tag quantitative proteomics in pediatric patients with osteomyelitis	5
Multiple Reaction Monitoring LC‐MS/MS Quantification of N‐Nitrosamine Drug Substance Related Impurities of Clonidine in Drug Substance and in Tablet Dosage Form	5
Pharmacokinetics and bioequivalence studies of fluvoxamine maleate tablets in healthy Chinese subjects	5
Retention behaviour of analytes in reversed‐phase high‐performance liquid chromatography—A review	5
Simultaneous determination and quality evaluation of 16 compounds in Ligustri Lucidi Fructus covering different regions and processed products using ultra‐high‐performance liquid chromatography‐mass s	5
Exploring Potential Targets and Pathways of Toxicity Attenuation Through Serum Pharmacochemistry and Network Pharmacology in the Processing of Aconiti Lateralis Radix Praeparata	5
Residue levels, household processing evolution, and risk assessment of chlorothalonil, SDS‐3701, metalaxyl, and dimethomorph in Dendrobium officinale Kimura et Migo	5
The JAK2^V617F mutation and childhood type1 diabetic nephropathy?	5
Effects of voriconazole and fluconazole on the pharmacokinetics of almonertinib in rats by UPLC–MS/MS	5
Issue Information	5
HPLC and GC–MS–based metabolic profiles and in vivo anticonvulsant, sedative, and antinociceptive potentials of truffles Tirmania nivea and Tirmania pinoyi hydromethanolic extracts in mi	5
Urinary excretion of silibinin diastereoisomers and their conjugated metabolites in rat and human at different dosages	5
Development and validation of a liquid chromatography coupled with tandem mass spectrometry method for determining total and unbound pamiparib in human plasma and brain tumors	5
Impurity profiling and stability‐indicating method development and validation for the estimation of assay and degradation impurities of midostaurin in softgel capsules using HPLC and LC–MS	5
Determination of six core components from Mahuang Xuanfei Zhike syrup in rat plasma and tissues by UPLC–MS/MS: Application to a pharmacokinetics and tissue distribution study	5
Pharmacokinetic study of five components of Fuzheng Huayu tablets in healthy human plasma	5
Exploring Active Ingredients of Hepatoprotective Effect of Raw and Stir‐Baked Gardeniae Fructus Based on Spectrum–Effect Relationship Analysis	5
Application of QbD based approach in development and validation of RP‐HPLC method for simultaneous estimation of methotrexate and baicalin in dual‐drug‐loaded liposomes	5
LC–MS/MS determination of HY072808, a novel candidate for treating atopic dermatitis, and its active metabolite: Application to a first‐in‐human pharmacokinetic study	5
Lipidomic‐based investigation into the therapeutic effects of polyene phosphatidylcholine and Babao Dan on rats with non‐alcoholic fatty liver disease	5
Method validation, dissipation and residue status of fluopicolide and fosetyl‐aluminium in citrus using a rapid extraction method coupled with ultra‐performance liquid chromatography–tandem mass spect	5
Assessment of metabolic stability and pharmacokinetics by LC–MS/MS and establishment of the safe dose of IMID‐2, a novel anticancer molecule under drug discovery	5
Analysis of omarigliptin forced degradation products by ultra‐fast liquid chromatography, mass spectrometry, and in vitro toxicity assay	5
An assessment of the antihyperlipidemic ingredients of Qi Ge Decoction based on metabolomics combined with serum pharmacochemistry	5
Metabolomics analysis reveals Oct4 overexpression drives metabolic reprogramming and enhanced glycolysis and pentose phosphate pathway in lung adenocarcinoma cells	5
High‐salt diet contributes to excess oxidative stress and abnormal metabolism in mouse ovaries	5
Determination by UHPLC‐QTOF‐HRMS of Phosphatidylethanol (PEth) in Dried Blood Spots: Method Validation and Practical Application of a Rising Alcohol Abuse Biomarker With Minimally Invasive Sampling	5
A MS^ALL quantitative method for the determination of Poloxamer 188 in rat plasma by UHPLC–Q‐TOF/MS and its application to pharmacokinetic study	5
Analytical method for urinary homovanillic acid and 5‐hydroxyindoleacetic acid levels using HPLC with electrochemical detection applied to evaluate children environmentally exposed to manganese	4
Optimization of extraction process and the antioxidant activity spectrum–effect relationship of Angelica dahurica	4
A green approach for the analysis of emtricitabine bictegravir and tenofovir in a pharmaceutical preparation using novel HPLC and spectrophotometric methods	4
A metabolism‐based study of the mechanism of action of Scrophularia ningpoensis Hemsl. on nephrogenic edema	4
Research progress in the application of proteomics technology in brain injury	4
Development and validation of an HPLC coupled with tandem mass spectrometry method for the determination of HSK7653, a novel super long‐acting dipeptidyl peptidase‐4 inhibitor, in human plasma and uri	4
Establishing a multi‐method approach for unprecedented detection and quantification of 13 genotoxic impurities (GTIs) in Apixaban drug substance through ultra‐performance liquid chromatography (UPLC)	4
An untargeted serum and urine lipidomics research based on UPLC–MS revealed the lipid alterations on adjuvant‐induced arthritis rats	4
Therapeutic drug monitoring of free vancomycin concentration in practice: A new analytical technique based on the HFCF–UF sample separation method	4
Bioanalytical methods for pharmacokinetic studies of antileishmanial drugs	4
Evaluating the behavior and principle of deep eutectic solvent on ephedrine‐type alkaloid extraction from Ephedrae Herba	4
Serum metabolic profile evidence for relationship between schizophrenia and depression: An untargeted metabolomics	4
Quantification of 3‐bromopyruvate in rat plasma by HPLC–MS/MS employing precolumn derivatization and the application to a pharmacokinetics study	4
Optimizing Mirabegron Stability in Human Plasma: Method Development, Validation Through Integration of Esterase Inhibitors and Stabilizers	4
A metabolomics study on the mechanisms of Gardeniae fructus against α‐naphthylisothiocyanate‐induced cholestatic liver injury	4
Screening ofBletilla striata,Bletilla ochraceaandOreorchis foliosadifferential metabolites based on metabolomics	4
Development and validation of an HPLC–MS/MS method to simultaneously quantify alectinib, crizotinib, erlotinib, gefitinib and osimertinib in human plasma samples, using one assay run	4
Determination and tissue distribution comparisons of five xanthones after orally administering crude and processed gamboge	4
Gas chromatography mass spectrometer determination of dimethylamine impurity in N,N‐dimethylformamide solvent by derivatization of N,N‐dimethylbenzamide with benzoyl chlori	4
Analysis of blood concentrations and clinical application of risdiplam in patients with spinal muscular atrophy using ultra‐high performance liquid chromatography–tandem mass spectrometry	4
Determination of fingerprints contents of different extracts and parts of six endemic Salvia taxa by GC–MS: Source species for valuable compounds with drug or drug potential	4
Olanzapine‐induced weight gain and lipid dysfunction in mice between different gender	4
Monitoring and method validation of organophosphorus/organochlorine pesticide residues in vegetables and fruits by gas chromatography	4
Differential metabolic profiles of ginsenosides in artificial gastric juice using ultra‐high‐pressure liquid chromatography coupled with linear ion trap‐Orbitrap mass spectrometry	4
Investigation of the apoptosis‐inducing effect of docetaxel by comprehensive LC–MS–based metabolomics and network pharmacology approaches	4
Preclinical pharmacokinetics and metabolism study of SCO‐267, a GPR40 full agonist, in beagle dogs using ultra‐high performance liquid chromatography coupled to tandem mass spectrometry	4
Combining network pharmacology with chromatographic fingerprinting and multicomponent quantitative analysis for the quality evaluation of Astragali Radix	4
Issue Information	4
Metabolism, pharmacokinetics, and bioavailability of yuanhuacine in rat using LC–MS	4
The antitumor activity and pharmacokinetics research of PPD‐Arg (Tos) using ultra‐performance liquid chromatography‐quadrupole‐time‐of‐flight mass spectrometry	4
	4
Oral solid dosage form using alternate crystalline neratinib maleate anhydrous form: Pharmaceutical, bioequivalent, and clinical perspectives	4
Validated HPLC‐UV Detection Method for Cefiderocol Quantification in a Critical Patient Receiving Fetcroja and Treated With Extracorporeal Replacement Therapies	4
Pharmacokinetics of IMM‐H012 in rats using ultra‐performance liquid chromatography‐tandem mass spectrometry	4
Determination of multiple active constituents in Da‐Huang‐Xiao‐Shi decoction using HPLC–LTQ–Orbitrap mass spectrometry: Application in comparing the differences in the formula and its constituent herb	4
Research Progress on the Material Basis of Traditional Chinese Medicines Based on Chemical Biology Methods	4
Multimodal integrated strategy for the discovery and identification of antiplatelet aggregation Q‐markers in Paris polyphylla var. yunnanensis	4
Issue Information	4
Electrophoretic deposition of polyaniline nanofibers on a stainless steel wire as an adsorbent for determination of tamoxifen by SPME/GC–FID in urine samples	4
Sample pretreatment and HPLC determination of antiplatelet drug ticagrelor in blood plasma from patients with acute coronary syndromes	4
Sorption and mobility assessment of tembotrione in soils of upper, trans and middle Gangetic plain zones of India	4
A RP‐HPLC–DAD method for analysis of Brazilian southeast brown propolis and its leishmanicidal properties	4
Advances in mass spectrometry for metabolomics: Strategies, challenges, and innovations in disease biomarker discovery	4
Platycodon grandiflorum Attenuates Non‐Alcoholic Fatty Liver Disease in Rats Through Regulating Inflammatory Response via PPARγ and TLR4/NF‐κB Signaling Pathway	4
A comparative metabolomics study on dried and processed Rehmannia Radix	4
Establishment and Application of Time‐Resolved Fluorescence Strip Method for Biotin Detection in Milk Powder	4
Stability‐indicating liquid chromatography method development for assay and impurity profiling of amitriptyline hydrochloride in tablet dosage form and forced degradation study	4
Evaluation of green and efficient deep eutectic solvents as media for extracting alkaloids from lotus leaf	4
Simultaneous determination of nirmatrelvir and ritonavir in human plasma using LC–MS/MS and its pharmacokinetic application in healthy Chinese volunteers	4
Issue Information	4
Simultaneous determination of four fungicide residues in figs using liquid chromatography tandem mass spectrometry	4
Determination of valproic acid and its six metabolites in human serum using LC–MS/MS and application to interaction with carbapenems in epileptic patients	4
Stability‐Indicating RP‐HPLC Method Development and Validation for Determination of Impurities in Loperamide Hydrochloride Capsules Dosage Form	4
Comparison of the Antioxidant Capacity of Cell Wall‐Broken Decoction Pieces and Traditional Decoction Pieces of Astragli Radix Based on HPLC‐ABTS Analytical Method	4