OOIR: Observatory of International Research

Papers

(The TQCC of Biomedical Chromatography is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Development of stability‐indicating method for separation and characterization of benidipine forced degradation products using LC–MS/MS	42
Matrix effect in bioanalytical assay development using supercritical fluid chromatography‐mass spectrometry	37
Characterization and Analytical Method Validation for Potential Impurities of a Merchantability Drug Substance Fluoxetine HCl	36
Residue levels and risk assessment of acetamiprid–pyridaben mixtures in cabbage under various open field conditions	36
Identification of Dendrobium devonianum Samples With Different Growth Years Based on Active Ingredients and Deduction of the Chemical Structural Transformation	33
Simultaneous Determination of Four Active Ingredients in Snow Chrysanthemum by HPLC With Determination of Its Antioxidant Activity in Vitro	31
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Development of a simultaneous quantification method of imatinib and sunitinib and their main metabolites and its application in patients with gastrointestinal stromal tumor	27
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Development of simultaneous quantitative analytical method for metabolites of hexosamine biosynthesis pathway in lung cancer cells using ultra‐high‐performance liquid chromatography‐tandem mass spectr	22
Issue Information	22
Evaluation of various polysaccharide‐based stationary phases for enantioseparation of chloro‐containing derivatives in normal phase liquid chromatography	21
Pioneering Human Plasma Detection of Haloperidol With 5‐pg/mL Sensitivity via Refined Sample Preparation and Advanced LC–MS/MS	20
An UHPLC–QTOF–MS‐based strategy for systematic profiling of chemical constituents and associated in vivo metabolites of a famous traditional Chinese medicine formula, Yinchenhao decoction	20
Issue Information	19
Preparation of 5‐hydroxymethylfurfural from Schisandra chinensis (Turcz.) Baill by high‐speed counter‐current chromatography: Comparison of conventional and consecutive separation	19
Lipidomics reveals the serum profiles of pediatric allergic rhinitis and its severity	19
Detection and identification of imperatorin metabolites in rat, dog, monkey, and human liver microsomes by ultra‐high‐performance liquid chromatography combined with high‐resolution mass spectrometry	18
Mango peel extracts and mangiferin chromatographic Fourier‐transform infrared correlation with antioxidant, antidiabetic, and advanced glycation end product inhibitory potentials using in silico model	17
The pharmacokinetics and tissue distribution of curcumin following inhalation administration in rats—A comparative analysis with oral and intravenous routes	17
A Validated UPLC‐MS/MS Method for Monitoring Temozolomide and Perillyl Alcohol Metabolites in Biological Matrices: Insights From a Preclinical Pharmacokinetic Study	17
Dissipation pattern and dietary risk assessment of some commonly used insecticides on tomato (Solanum lycopersicum L.)	17
The Isolation and Separation of Hydrophobic Bioactive Peptide Obtained From Tilapia ( Oreochromis niloticus	17
In vivo detection of the epimer metabolites of sweroside via ultra‐performance liquid chromatography time‐of‐flight mass spectrometry combined with DNPH derivatization	16
Delineation of prototypical degradation mechanism, characterization of unknown degradation impurities by liquid chromatography–quadrupole‐time‐of‐flight–tandem mass spectrometry and stability‐indicati	16

Review of HPLC–MS methods for the analysis of nicotine and its active metabolite cotinine in various biological matrices	16
Characterization and traceability of two generations of standard reference material for the measurement of vitamin K₁(phylloquinone) at endogenous concentrations in human plasma and serum	15
Development and validation of a stability‐indicating ultra‐high‐performance liquid chromatography method for the estimation of ibrutinib and trace‐level quantification of related substances using qual	15
Investigation of the therapeutic effect of Hedan tablets on high‐fat diet‐induced obesity in rats by GC–MS technology and 16S ribosomal RNA gene sequencing	15
Spectroscopic characterization and pharmacokinetic evaluation of amorphous solid dispersions of glibenclamide for bioavailability enhancement in Wistar rats	15
Screening for α‐glucosidase inhibitors from Selaginella uncinata based on the ligand fishing combined with ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight–tandem m	15
Metabolic Profiling of 5‐Methoxypinocembroside and Pharmacokinetics Study of Its Major Metabolite Alpinetin in Rat Plasma by UHPLC–MS	14
Application of Proteomics in the Study of Toxicology and Toxic Markers of Traditional Chinese Medicines	14
Issue Information	14
Chromatographic analysis and antioxidant potency of the crude extract of Xanthium spinosum in various fractions	14
Insight gained via ultra‐performance liquid chromatography tandem mass spectrometry‐based metabolomics: Protective effect of Artemisia argyi H.Lév. & Vaniot essential oil on lipopolysacchar	14
Issue Information	13
Pharmacokinetic and pharmacodynamic herb–drug interactions of common over‐the‐counter pain medications	13
Determination of three C18‐oxygenated steroids in adrenal lesion segments in primary aldosteronism by super‐selective adrenal venous sampling and LC/ESI–MS/MS	13
Issue Information	13
Potential role of the methanolic extract for Olea europaea (stem and leaves) on sporulation of Eimeria papillata oocysts: In vitro study	13
Development and validation of gas chromatography with electron capture detection method using QuEChERS for pesticide residue determination in cucumber	12
Comparative phytochemical study of methanolic and ethanolic extracts of Thymus linearis and their antibacterial and antioxidant potential	12
Multimodal Metabolomics Analysis Reveals That Classic Decoction Mitigates Myocardial Ischemia‐Induced Damage by Modulating Energy and Branched‐Chain Amino Acid Metabolism	12
The Effect of Kaempferol on Valsartan Metabolism In Vitro and In Vivo and the Underlying Mechanism With Cytochrome p450 Using UPLC‐MS/MS	12
Screening of Antiaging Active Components of Morinda officinalis and the Mechanism of Enhanced Efficacy After Salt‐Steaming	12
RP‐HPLC method development, validation and pharmacokinetic applicability in preclinical evaluation of rhein treated with novel diacerein eutectics	12
Evaluation of lipophilicity and drug‐likeness of donepezil‐like compounds using reversed‐phase thin‐layer chromatography	12
Development and validation of novel RP‐HPLC method for midostaurin determination using analytical quality by design approach from regulatory perspective and determination of major degradation compound	12
Online preconcentration and determination of five alkaloids in Yangxinshi tablet by large‐volume sample stacking and micelle to solvent stacking in cyclodextrin‐modified electrokinetic chromatography	12
Therapeutic potential of Shaoyao Gancao Decoction in mitigating anti‐tuberculosis drug‐induced liver injury through Nrf‐2/HO‐1/NF‐κB signaling	11
Systematic analysis of chemical profiles of Sophorae tonkinensis Radix et Rhizoma in vitro and in vivo using UPLC‐Q‐TOF‐MS^E	11
Metabolomic analysis of amino acids and organic acids in aging mouse eyes using gas chromatography–tandem mass spectrometry	11
Chromatography in Preparative/Industrial Scale Separation of Enantiomeric Mixtures	11
A pharmacokinetics interaction study of antiplatelet agents aspirin and clopidogrel combined with dl‐3‐n‐butylphthalide in rats by liquid chromatography–tandem mass spectrometry	11
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Development of a joint derivatization protocol for the unequivocal identification of the monosaccharide composition in four dendrobium polysaccharides and free monosaccharide by GC–MS	11
Profiling of widely targeted metabolomics for the identification of chemical composition in epidermis, xylem and pith of Gleditsiae Spina	11
Dissipation and Risk Assessment of a Combination Product of Chlorantraniliprole + Abamectin and Spirotetramat in Pomegranate Fruit and Juice	11
Optimization of Environmentally Sustainable UPLC‐PDA Method Using Box–Behnken for Simultaneous Quantifying Curcumin and Candesartan Cilexetil in On‐Demand Formulation for Treatment of Brain Ischemic I	11
Comparative analysis of the liver‐protective effects of raw and stir‐fried semen of Hovenia dulcis in rats via gas chromatography–mass spectrometry–based serum metabolomic profiling	10
Effect of concomitant oral administration of ethanol on the pharmacokinetics of nicardipine in rats	10
The impact of insecticides containing deltamethrin and cyfluthrin on the composition of surface compounds in the larvae, females and males of Tenebrio molitor	10
A liquid chromatography–tandem mass spectrometry method development for the quantification of favipiravir drug and its related impurities in rat plasma and its application to pharmacokinetic studies	10
Farfarae Flos Mitigates Cigarette Smoking‐Induced Lung Inflammation by Regulating the Lysophosphatidylcholine Biosynthesis and Tryptophan Metabolism	10
Determination of Schaftoside and Isoschaftoside in Rat Plasma Utilizing UPLC‐MS/MS	10
Dissipation Kinetics, Risk Assessment, and Decontamination Studies of Pyridalyl in Cabbage by GC–MS/MS	10
Supported liquid extraction combined with liquid chromatography tandem mass spectrometry for the quantitative analysis of a TLR7 agonist imiquimod LFX453 in plasma at low picograms per milliliter: Met	9
Process Optimization of Stir‐Fried Inonotus hispidus Based on the Box–Behnken Design‐Response Surface Method and the Component Variations During the Stir‐Frying Process	9
Spectrum–effect relationship between HPLC fingerprint and hypoglycemic of litchi leaves (Litchi chinensis Sonn) in vitro	9
Simultaneous quantitation of urine aldosterone and tetrahydroaldosterone in healthy Chinese subjects using a validated LC–MS/MS method	9
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Serum metabolome analysis reveals medicinal fungi Phellinus igniarius ameliorated type 2 diabetes mellitus indications in rats via modulation of amino acid and carbohydrate metabolism	9
Hybrid solid‐phase extraction to overcome interference due to phospholipids for determination of neratinib in human plasma using UPLC–MS/MS	9
Supercritical fluid chromatography for milligram preparation of enantiomers	9

Investigating the in vivo effect of Tribulus terrestris extract in middle cerebral artery occlusion rats using LC–MS‐based metabolomics combined with molecular docking	9
Serum and urine metabolomics based on UPLC–QTOF/MS reveal the effect and potential mechanism of “schisandra–evodia” herb pair in the treatment of Alzheimer's disease	9
Quality Difference Analysis of Pomegranate Peels Based on Multidimensional Fingerprint With Chemical Pattern Recognition	9
Assessment of remdesivir and its nucleoside metabolite in beagle dogs and healthy humans by liquid chromatography coupled with triple quadrupole mass spectrometry	9
Amelioration of Guishao Yigong Decoction on Colorectal Cancer Through the Integration of 16S rRNA Sequencing and Fecal Metabolomics	9
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An LC–ESI–MS/MS assay for the therapeutic drug monitoring of 15 antiseizure medications in plasma of children with epilepsy	9
Simultaneous Determination of Buspirone, Alprazolam, Clonazepam, Diazepam, and Lorazepam by LC‐MS/MS: Evaluation of Greenness Using AGREE Tool	9
A Simple Rapid HPLC‐UV Method for Assessing C‐Terminal Arginine Content in Darbepoetin Alfa	9
Si Miao San relieves hyperuricemia by regulating intestinal flora	9
LC–MS/MS method for quick detection of vonoprazan fumarate in human plasma: Development, validation and its application to a bioequivalence study	8
Identifying of Anticoagulant Ingredients From Moutan Cortex Based on Spectrum‐Effect Relationship Analysis Combined With GRA, PLS, and SVM Algorithms	8
Phytochemical profile and pharmacological potential of Withania somnifera whole plant extracts	8
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Human plasma ricinine quantification by LC–HRMS after micro‐solid‐phase elution	8
Quantitation of tazemetostat in human plasma using liquid chromatography–tandem mass spectrometry	8
Determination of 59 Psychotropic Drugs, Including Antipsychotics, Antidepressants, Antiepileptics, Anti‐Alcohol Abuse Drugs, Anti‐ADHD Drugs, and Their Metabolites in Urine Using LC–MS/MS for Medicati	8
Rapid Analysis of Chemical Constituents in Blachia pentzii Leaves and Predictive Analysis of the Pharmacological Effects for Treatment of Rheumatoid Arth	8
Metabolite Identification of Huangqi Guizhi Wuwu Granules in Rat Urine and Feces Based on Ultra–High‐Performance Liquid Chromatography With Quadrupole Time‐of‐Flight Mass Spectrometry	8
The Continued Mismeasurement of Plasma Serotonin: A Systematic Review	8
Developing LC–MS/MS methods to quantify rivaroxabanin human plasma and urine: Application to therapeutic drug monitoring	8
A Simple, Sensitive, and Stable LC–MS/MS Method for the Simultaneous Determination and Pharmacokinetic Study of Dapagliflozin and Its Metabolite D3OG in Human Plasma	8
An effective LC–MS method for the simultaneous determination of a potential anti‐rheumatoid arthritis drug, carboxyamidotriazole, and its major metabolite in rat plasma	8
Impact of introducing a new biological matrix into a validated bioanalytical method: Focus on matrix protein content	8
Favipiravir (SARS‐CoV‐2) degradation impurities: Identification and route of degradation mechanism in the finished solid dosage form using LC/LC–MS method	8
Lateal Flow Immunoassay for Sensitive and Rapid Detection of Methylisomiroestrol in Pueraria candollei Using Monoclonal Antibody	8
HPLC–PDA identification and resolution of rufinamide forced degradation impurities: A congregated chemometric expedite optimization coupled with factorials and desirability	8
Comparative Chromatographic Analysis of Amino Acids in the Seeds of Three Nigella L. Representatives	8
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Green method by National Environmental Methods Index and Eco‐Scale Assessment for evaluation of gatifloxacin‐based product by HPLC	8
A selective, sensitive and fast LC–MS/MS method for cabotegravir quantification in rat plasma and pharmacokinetic investigations	8
Metabolic characteristics and pharmacokinetic differences of Qiwei Tongbi oral liquid in rheumatoid arthritis rats	7
Metabolomic comparison between natural Huaier and artificial cultured Huaier	7
Metabolomics and serum pharmacochemistry revealed the preventive mechanism of Gushudan in kidney‐yang‐deficiency‐syndrome rats	7
Lipidomics reveals the dysregulated ceramide metabolism in oxidized low‐density lipoprotein‐induced macrophage‐derived foam cell	7
Innovative UPLC technique for concurrent quantification of etofenamate and benzyl nicotinate in the presence of methylparaben and benzyl alcohol in their topical cream: Greens, white, and Six Sigma me	7
Synthesis, characterization and control of eight process‐related and two genotoxic fingolimod impurities by a validated RP‐UPLC method	7
Rapid analysis of components in Qizhiweitong tablets and plasma after oral administration in rats by UPLC–Q‐TOF–MS/MS based on a self‐developed database	7
A Simple Eco‐Friendly Stability‐Indicating HPLC Method for Determination of NETILMICIN in Bulk and Ophthalmic Solution	7
Comparative analysis of six aconitine‐type alkaloids in decocting extracts between the different processed Fuzi (Aconiti Lateralis Radix praeparata) and its pharmacokinetic behavior in rats by HPLC‐MS	7
Quantitation of plasma angiotensin II in healthy Chinese subjects by a validated liquid chromatography tandem mass spectrometry method	7
Metabolic Profile In Vivo and Potential Mechanisms of Danggui Jianzhong Decoction Against Gastric Ulcer by Ultra‐High‐Performance Quadrupole Time‐of‐Flight Mass Spectrometry Combined With Network Phar	7
The delivery of nanoparticles improves the pharmacokinetic properties of celecoxib to open a therapeutic window for oral administration of insoluble drugs	7
Study on Quality Evaluation of Processed Cimicifuga Rhizoma Based on UPLC Fingerprint and Chemometrics	7
UPLC Estimate of Sofosbuvir and Ledipasvir Utilizing Greenness Tool in Conjunction With an Analytical Quality by Design	7
LC‐HRMS‐based targeted metabolomics for high‐throughput and quantitative analysis of 21 growth inhibition‐related metabolites in Chinese hamster ovary cell fed‐batch cultures	7
Spectrum‐Effect Relationship Between Fingerprints and Anti‐Inflammatory and Antitussive Activities of Raw and Processed Mume Fructus Extracts	7
Simultaneous Quantification of Filgotinib and Its Active Metabolite in Human Plasma Using Liquid Chromatography–Tandem Mass Spectrometry: Validation and Clinical Application	7
Metabolism of the Total Flavonoid Extract of Lithocarpus litseifolius (Hance) Chun in Rats	7
In vitro wound healing properties, antioxidant activities, HPLC–ESI–MS/MS profile and phytoconstituents of the stem aqueous methanolic extract of Dracaena reflexa Lam	7
Development and Validation of a Rapid and Simple UHPLC–MS/MS Method for the Determination of Colchicine in Human Plasma	7
Network pharmacology study on fermented soybeans for the prevention of Alzheimer's disease in older individuals	7
LC–MS/MS Assay for Simultaneous Quantification of Dual‐Targeting 1,5‐Diaryl‐1,2,4‐Triazole Sulfonamides (WA11–13) in Human Plasma	7
A simple, high‐throughput and validated LC–MS/MS method for the determination of azithromycin in human plasma and its application to a clinical pharmacokinetic study	7
Widely Targeted Metabolomics Reveals the Bioactive Metabolites and Antioxidant Activities of Chinese Yam (Dioscorea opposita Thunb.) Peel	7
Chemical characterization, multivariate analysis and comparison of biological activities of different parts of Fraxinus mandshurica	7
Identification of the metabolites of nimbolide in rat by liquid chromatography combined with quadrupole/orbitrap mass spectrometry	7
Detection of Pesticide Residues in Fruits and Vegetables Involving Different Chromatographic Techniques (LC–MS/MS, GC–MS/MS, GC and HPLC)	7
A novel LC–MS/MS approach to [¹⁹F]‐alfatide and alfatide for application in preclinical pharmacokinetics	6
Residue levels, household processing evolution, and risk assessment of chlorothalonil, SDS‐3701, metalaxyl, and dimethomorph in Dendrobium officinale Kimura et Migo	6
Development of Mobile‐Phase Buffers and Evaluation of Analytical Performance for HbA_1c Assays	6
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Protective effects of Typhonii Rhizoma in rheumatoid arthritis rats revealed by integrated metabolomics and network pharmacology	6
Screening and characterization of cosmetic efficacy components of Terminalia chebula based on biological activity‐guided methodology	6
A robust, accurate, sensitive LC–MS/MS method to measure indoxyl sulfate, validated for plasma and kidney cells	6
Degradation pathways and impurity profiling of the anticancer drug apalutamide by HPLC and LC–MS/MS and separation of impurities using Design of Experiments	6
A Method for Analysis of Free and Total Ropivacaine in Dog Plasma Using UHPLC–MS/MS	6
A Simple and Sensitive LC‐MS/MS Method for the Determination of Mobocertinib and Its Metabolite Desmethyl‐Mobocertinib in Human Plasma and Its Application to Clinical Pharmacokinetic Study	6
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Metabolomics study of the hepatoprotective effect of total flavonoids of Mallotus apelta leaf in carbon tetrachloride‐induced liver fibrosis in rats	6
Metabolomic analysis of the sera of patients with the long‐term inhalation of caffeine‐sodium benzoate using LC–MS	6
Quantification of Trans‐ and Cis‐Vitamin K1 Isomers in Human Plasma by a Rapid and Sensitive LC–MS/MS Method With Surrogate Matrix	6
Simultaneous quantification of icaritin and its novel 3‐methylcarbamate prodrug in rat plasma using HPLC–MS/MS and its application to pharmacokinetic study	6
The JAK2^V617F mutation and childhood type1 diabetic nephropathy?	6
Metabolomics analysis reveals Oct4 overexpression drives metabolic reprogramming and enhanced glycolysis and pentose phosphate pathway in lung adenocarcinoma cells	6
Retention behaviour of analytes in reversed‐phase high‐performance liquid chromatography—A review	6
Spectrum–effect relationship study between ultra‐high‐performance liquid chromatography fingerprints and anti‐hepatoma effect in vitro of Cnidii Fructus	6
Revealing the mechanism of Gualou–Xiebai against myocardial ischemia based on network pharmacology and energy metabolism strategies	6
Investigation of the Potential Material Basis and Mechanism of Astragali Radix Against Adriamycin‐Induced Nephropathy Model Rat by ¹H NMR and MS‐Based Untargeted Metabolomics Analysis	6
Noval Selective Ligand‐Extraction of Bioactive Components in Complex Natural Products Applying Immobilized Multi‐Target Magnetic Beads	6

Multiple Reaction Monitoring LC‐MS/MS Quantification of N‐Nitrosamine Drug Substance Related Impurities of Clonidine in Drug Substance and in Tablet Dosage Form	6
A validated stability‐indicating reversed‐phase‐UPLC method for simultaneous estimation of promethazine hydrochloride, methylparaben, propylparaben and sodium benzoate assay of cough suppressant and a	6
Featured Cover	6
Determination of the dissipative behaviour and final residue of sodium nitrophenol in jujube by liquid chromatography–tandem mass spectrometry	6
LC–MS/MS determination of HY072808, a novel candidate for treating atopic dermatitis, and its active metabolite: Application to a first‐in‐human pharmacokinetic study	6
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Dispersive liquid–liquid microextraction and Monte Carlo simulation of margin of safety for octocrylene, EHMC, 2ES, and homosalate in sunscreens	6
Elucidating the mechanisms underlying the anti‐hyperlipidemic effects of Laportea bulbifera using integrated serum metabolomics and network pharmacology	6
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Method validation, dissipation and residue status of fluopicolide and fosetyl‐aluminium in citrus using a rapid extraction method coupled with ultra‐performance liquid chromatography–tandem mass spect	6
Mechanisms exploration of terrestrosin D on pulmonary fibrosis based on plasma metabolomics and network pharmacology	6
Issue Information	5
Development and validation of a liquid chromatography coupled with tandem mass spectrometry method for determining total and unbound pamiparib in human plasma and brain tumors	5
Metabolism of four novel structural analogs of ketamine, 2‐FXE [2‐(ethylamino)‐2‐(2‐fluorophenyl) cyclohexan‐1‐one], 2‐MDCK [2‐(methylamino)‐2‐(o‐tolyl) cyclohexan‐1‐one], 3‐DMXE [2‐(ethylamino	5
Study on the material basis of Zhujing pill in treating fundus lesions through component analysis and network pharmacology	5
Urinary excretion of silibinin diastereoisomers and their conjugated metabolites in rat and human at different dosages	5
An assessment of the antihyperlipidemic ingredients of Qi Ge Decoction based on metabolomics combined with serum pharmacochemistry	5
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Pharmacokinetics and bioequivalence studies of fluvoxamine maleate tablets in healthy Chinese subjects	5
Determination and tissue distribution comparisons of five xanthones after orally administering crude and processed gamboge	5
Exploring Potential Targets and Pathways of Toxicity Attenuation Through Serum Pharmacochemistry and Network Pharmacology in the Processing of Aconiti Lateralis Radix Praeparata	5
Anti‐rheumatoid arthritis effects of Xanthii Fructus by affecting the PI3K‐AKT signaling pathway based on TMT‐labeled quantitative proteomics	5
Nano‐LC: An updated review	5
Bone and periosteum protein analysis via tandem mass tag quantitative proteomics in pediatric patients with osteomyelitis	5
Development and validation of an HPLC coupled with tandem mass spectrometry method for the determination of HSK7653, a novel super long‐acting dipeptidyl peptidase‐4 inhibitor, in human plasma and uri	5
Simultaneous determination and quality evaluation of 16 compounds in Ligustri Lucidi Fructus covering different regions and processed products using ultra‐high‐performance liquid chromatography‐mass s	5
Trace‐level determination of potential genotoxic impurities in quetiapine fumarate using LC–MS	5
Preparation, characterization, and pharmacokinetics of oridonin‐loaded liposomes	5
Pharmacokinetic study of five components of Fuzheng Huayu tablets in healthy human plasma	5
Correction to “A LC–MS/MS Method for the Simultaneous Determination of 6‐Cyanodopamine, 6‐Nitrodopamine, 6‐Nitrodopa, 6‐Nitroadrenaline and 6‐Bromodopamine in Human Plasma and Its Clinical Application	5
In Silico Assessment and Quantitative Estimation of Potential Toxic Impurities From Propafenone (PFN) Through Generic Route and Using UPLC‐MS/MS Technique	5
Unraveling the Mechanisms of Modified Si Miao San in Treating Gouty Arthritis: Network Pharmacology and Experimental Validation	5
Mechanism of Jinteng Qingbi granules in the treatment of rheumatoid arthritis using metabolomics analysis	5
Bioanalytical Tandem Mass Spectrometry Method for Precise Measurement of Tranexamic Acid in Human Plasma With Unveiling Methodological Advancement: Green Assessment With Advanced Metrics	5
A new method providing complementary explanation of the blood‐enriching function and mechanism of unprocessed Angelica sinensis and its four kinds of processed products based on tissue‐integrat	5
Jiedu Tongluo Tiaogan Formula Modulates Glycolipid Metabolism in Type 2 Diabetes via Pyroptosis: Network Pharmacology and In Vivo Analysis	5
Absorption characteristics of ilexgenin A and ilexsaponin B1 in human umbilical vein endothelial cells after administration of the total triterpenoid saponins from Ilex pubescens	5
Assessment of metabolic stability and pharmacokinetics by LC–MS/MS and establishment of the safe dose of IMID‐2, a novel anticancer molecule under drug discovery	5
A simple and sensitive liquid chromatography triple quadrupole mass spectrometry method for the determination of XL092 in monkey plasma and its application to pharmacokinetic study	5
Stability‐Indicating RP‐HPLC Method Development and Validation for Determination of Impurities in Loperamide Hydrochloride Capsules Dosage Form	5
Integrated pharmacokinetics of Huangqi Jianzhong Tang in normal and chronic atrophic gastritis rats	5
Issue Information	5
Application of QbD based approach in development and validation of RP‐HPLC method for simultaneous estimation of methotrexate and baicalin in dual‐drug‐loaded liposomes	5
A novel standard‐free detection of adulteration method for sildenafil derivatives in dietary supplements	5
High‐salt diet contributes to excess oxidative stress and abnormal metabolism in mouse ovaries	5
Highly sensitive liquid chromatography–mass spectrometry method for the quantitative analysis of mometasone furoate in human plasma: Method validation and application to clinical pharmacokinetic studi	5
LC–HRMS methods for the quantification of two artemisinin drugs and their metabolites in rat blood and plasma	5
HPLC and GC–MS–based metabolic profiles and in vivo anticonvulsant, sedative, and antinociceptive potentials of truffles Tirmania nivea and Tirmania pinoyi hydromethanolic extracts in mi	5
Investigation Into the Chemical Constituents and Cytotoxic Effects on Lung Cancer Cells of the Rhizomes of Polygonum bistorta L. and Polygonum paleaceum Wall.	5
Development, evaluation of critical method variables and stability assessment using a Box–Behnken design for the determination of organic impurities in a pharmaceutical dosage form of a centrally acti	5
In vivo and in vitro chemical composition and biological activity of traditional vs. dispensing granule decoctions of Coptidis Rhizoma: A comparative study	5
Research Progress on the Material Basis of Traditional Chinese Medicines Based on Chemical Biology Methods	5
Quantification of 3‐bromopyruvate in rat plasma by HPLC–MS/MS employing precolumn derivatization and the application to a pharmacokinetics study	5
Determination by UHPLC‐QTOF‐HRMS of Phosphatidylethanol (PEth) in Dried Blood Spots: Method Validation and Practical Application of a Rising Alcohol Abuse Biomarker With Minimally Invasive Sampling	5
Oral solid dosage form using alternate crystalline neratinib maleate anhydrous form: Pharmaceutical, bioequivalent, and clinical perspectives	5
Effects of voriconazole and fluconazole on the pharmacokinetics of almonertinib in rats by UPLC–MS/MS	5
Non‐Targeted Metabolomics Analysis of Metabolite Differences in Inocutis tamaricis Under Different Culture Conditions	5
Pharmacokinetics of IMM‐H012 in rats using ultra‐performance liquid chromatography‐tandem mass spectrometry	5
Metabolic profiling of emodin drug‐induced liver injury and silybin treatment in rats using ultra‐performance liquid chromatography‐quadrupole‐time‐of‐flight‐mass spectrometry: A metabolomic and mecha	5
Preparation of amentoflavone‐loaded DSPE‐PEG₂₀₀₀ micelles with improved bioavailability and in vitro antitumor efficacy	5
Fluorescent immunochromatography of vancomycin in plasma: A rapid and sensitive quantitative analysis	5
Analysis of omarigliptin forced degradation products by ultra‐fast liquid chromatography, mass spectrometry, and in vitro toxicity assay	5
Determination of six core components from Mahuang Xuanfei Zhike syrup in rat plasma and tissues by UPLC–MS/MS: Application to a pharmacokinetics and tissue distribution study	5
Exploring Active Ingredients of Hepatoprotective Effect of Raw and Stir‐Baked Gardeniae Fructus Based on Spectrum–Effect Relationship Analysis	5
Targeted profiling of rodent unconjugated bile acids using GC–MS to determine the influence of high‐fat diet	4
Integration of lipidomics and metabolomics reveals plasma and urinary profiles associated with pediatric Mycoplasma pneumoniae infections and its severity	4
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Sorption and mobility assessment of tembotrione in soils of upper, trans and middle Gangetic plain zones of India	4
Advances in mass spectrometry for metabolomics: Strategies, challenges, and innovations in disease biomarker discovery	4
Residues determination, risk assessment, and dissipation behavior of myclobutanil formulation on apple	4
Poly‐pathways metabolomics for high‐yielding cordycepin of Cordyceps militaris	4
Integrating network pharmacology and experimental validation to explore the mitophagy‐associated pharmacological mechanism of modified Shisiwei Jianzhong decoction against aplastic anemia	4
Protective Effects and Mechanisms of Active Fractions of Ixeris sonchifolia on Rats With Toxic Heat and Blood Stasis Syndrome Revealed by Pharmacodynamics and Metabonomics	4
Chromatographic authentication of botanical origin: Herbaceous pollen profiling with HPLC, HPTLC and GC–MS analysis	4
Quantification of SHR0302 in human plasma by UPLC–MS/MS and application to a pharmacokinetic study	4
Issue Information	4
Research progress in the application of proteomics technology in brain injury	4
Preclinical pharmacokinetics and metabolism study of SCO‐267, a GPR40 full agonist, in beagle dogs using ultra‐high performance liquid chromatography coupled to tandem mass spectrometry	4
Screening of Bletilla striata, Bletilla ochracea and Oreorchis foliosa differential metabolites based on metabolomics	4
The protective effect of electroacupuncture on the renal cortex of SHRs: A metabonomic analysis	4
Metabolite profiling of remibrutinib in rat and human liver microsomes using liquid chromatography combined with benchtop orbitrap high‐resolution mass spectrometry	4
Residue levels of emamectin benzoate, imidacloprid and its major metabolites in cabbage from 12 regions in China and dietary risk assessment	4
Validated HPLC‐UV Detection Method for Cefiderocol Quantification in a Critical Patient Receiving Fetcroja and Treated With Extracorporeal Replacement Therapies	4
Comprehensive phytochemical analysis of Salvia hispanica L. callus extracts using LC–MS/MS	4
Development and validation of LC–MS/MS methods for the simultaneous quantification of sofosbuvir and its major metabolite (GS‐331007) in blood plasma and cerebrospinal and seminal fluid: Application t	4
Simultaneous Determination of 14 Bioactive Components in Fangji Huangqi Tang by UHPLC‐QqQ‐MS Technique	4
Differential metabolic profiles of ginsenosides in artificial gastric juice using ultra‐high‐pressure liquid chromatography coupled with linear ion trap‐Orbitrap mass spectrometry	4
Olanzapine‐induced weight gain and lipid dysfunction in mice between different gender	4
Determination of valproic acid and its six metabolites in human serum using LC–MS/MS and application to interaction with carbapenems in epileptic patients	4
Analytical method for urinary homovanillic acid and 5‐hydroxyindoleacetic acid levels using HPLC with electrochemical detection applied to evaluate children environmentally exposed to manganese	4
Inhibition of imrecoxib on mRNA and protein expression of CYP2C11 enzyme in rats	4
Characterization of diterpene metabolism in rats with ingestion of seed products from Euphorbia lathyris L. (Semen Euphorbiae and Semen Euphorbiae Pulveratum) using UHPLC‐Q‐Exactive	4
Urine metabolomic characteristics of female patients with occupational chronic cadmium poisoning after 15 years of treatment	4