Journal of Cerebral Blood Flow and Metabolism

Article	Citations
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*	567
Regulation of blood–brain barrier integrity by microglia in health and disease: A therapeutic opportunity	206
Single-cell RNA-seq reveals the transcriptional landscape in ischemic stroke	94
Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update	90
Benefits of exercise training on cerebrovascular and cognitive function in ageing	74
Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1	66
MiR-17-92 enriched exosomes derived from multipotent mesenchymal stromal cells enhance axon-myelin remodeling and motor electrophysiological recovery after stroke	61
Tissue no-reflow despite full recanalization following thrombectomy for anterior circulation stroke with proximal occlusion: A clinical study	61
Transcriptome analysis reveals sexual disparities in gene expression in rat brain microvessels	56
Body mass index, time of day and genetics affect perivascular spaces in the white matter	55
Collateral status contributes to differences between observed and predicted 24-h infarct volumes in DEFUSE 3	54
Causes and consequences of baseline cerebral blood flow reductions in Alzheimer’s disease	54
Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study	48
Epitranscriptomic regulation by m6A RNA methylation in brain development and diseases	46
Transcriptomic characterization of microglia activation in a rat model of ischemic stroke	45
Transfer function analysis of dynamic cerebral autoregulation: A CARNet white paper 2022 update	45
Mitochondrial quality control in acute ischemic stroke	43
Neuroinflammatory responses of microglia in central nervous system trauma	40
Genome-wide transcriptomic analysis of microglia reveals impaired responses in aged mice after cerebral ischemia	40
Galectin-3 protects against ischemic stroke by promoting neuro-angiogenesis via apoptosis inhibition and Akt/Caspase regulation	37
Interleukin-4 improves white matter integrity and functional recovery after murine traumatic brain injury via oligodendroglial PPARγ	37
Hypoxia induces de novo formation of cerebral collaterals and lessens the severity of ischemic stroke	36
HDAC inhibition reduces white matter injury after intracerebral hemorrhage	36
Three-dimensional ultrastructure of the brain pericyte-endothelial interface	35
Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome	35

Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns	35
PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflamm	35
Altered glymphatic enhancement of cerebrospinal fluid tracer in individuals with chronic poor sleep quality	35
Deep white matter hyperintensity is associated with the dilation of perivascular space	35
Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) with 15O PET in healthy adults	34
Perfusion imaging-based tissue-level collaterals predict ischemic lesion net water uptake in patients with acute ischemic stroke and large vessel occlusion	34
Regional hyperperfusion in older adults with objectively-defined subtle cognitive decline	34
Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective	33
Impact of sex andAPOEε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study	33
Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model	32
Change and predictive ability of circulating immunoregulatory lymphocytes in long-term outcomes of acute ischemic stroke	32
Altered coupling of cerebral blood flow and functional connectivity strength in visual and higher order cognitive cortices in primary open angle glaucoma	31
Role of perivascular and meningeal macrophages in outcome following experimental subarachnoid hemorrhage	31
Role of endothelial nitric oxide synthase for early brain injury after subarachnoid hemorrhage in mice	30
Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET	30
Hippocampal blood–brain barrier permeability is related to the APOE4 mutation status of elderly individuals without dementia	29
Distinct features of brain perivascular fibroblasts and mural cells revealed by in vivo two-photon imaging	29
D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI	28
Glymphatic pathways in the gyrencephalic brain	28
Distinct peripheral blood monocyte and neutrophil transcriptional programs following intracerebral hemorrhage and different etiologies of ischemic stroke	28
Simulation of oxygen transport and estimation of tissue perfusion in extensive microvascular networks: Application to cerebral cortex	27
Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task	27
Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury	26
Integrative cerebral blood flow regulation in ischemic stroke	26
Cerebrovascular phenotypes in mouse models of Alzheimer’s disease	26
Opposed hemodynamic responses following increased excitation and parvalbumin-based inhibition	26
Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults	25
Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage	25
Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques	25
How expensive is the astrocyte?	25
Upregulation of ribosome complexes at the blood-brain barrier in Alzheimer's disease patients	25
Preclinical and clinical evidence of IGF-1 as a prognostic marker and acute intervention with ischemic stroke	24
Mechanisms of the negative potential associated with Leão’s spreading depolarization: A history of brain electrogenesis	24
Glucagon-like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review	24
Profiling cerebrovascular function in migraine: A systematic review and meta-analysis	24
Microvascular changes associated with epilepsy: A narrative review	24
Adult-induced genetic ablation distinguishes PDGFB roles in blood-brain barrier maintenance and development	24
Understanding the brain uptake and permeability of small molecules through the BBB: A technical overview	24
Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy	24
Light sheet fluorescence microscopy of optically cleared brains for studying the glymphatic system	23
Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue	23
Aerobic exercise improves hippocampal blood flow for hypertensive Apolipoprotein E4 carriers	23
Glucose sparing by glycogenolysis (GSG) determines the relationship between brain metabolism and neurotransmission	23
MicroRNA-30a regulates acute cerebral ischemia-induced blood–brain barrier damage through ZnT4/zinc pathway	23
Microglia/macrophage polarization: Fantasy or evidence of functional diversity?	23
4D flow MRI for non-invasive measurement of blood flow in the brain: A systematic review	22
Low neuronal metabolism during isoflurane-induced burst suppression is related to synaptic inhibition while neurovascular coupling and mitochondrial function remain intact	22
Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study	22
Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression	22
Microglial phagocytosis and regulatory mechanisms after stroke	22

In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET	22
Neurovascular coupling dysfunction in end-stage renal disease patients related to cognitive impairment	22
Lenticulostriate artery combined with neuroimaging markers of cerebral small vessel disease differentiate the pathogenesis of recent subcortical infarction	21
In vivo synaptic density relates to glucose metabolism at rest in healthy subjects, but is strongly modulated by regional differences	21
Connexin43 promotes angiogenesis through activating the HIF-1α/VEGF signaling pathway under chronic cerebral hypoperfusion	21
Targeting neutrophils as a novel therapeutic strategy after stroke	21
Aging related impairment of brain microvascular bioenergetics involves oxidative phosphorylation and glycolytic pathways	21
Linking cortical atrophy to white matter hyperintensities of presumed vascular origin	21
Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury	20
Optimized lactoferrin as a highly promising treatment for intracerebral hemorrhage: Pre-clinical experience	20
CD36 deficiency reduces chronic BBB dysfunction and scar formation and improves activity, hedonic and memory deficits in ischemic stroke	20
More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke	20
Choroid plexus function in neurological homeostasis and disorders: The awakening of the circadian clocks and orexins	20
Functional dynamics of dopamine synthesis during monetary reward and punishment processing	19
Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation	19
Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke	19
A meta-analysis of remote ischaemic conditioning in experimental stroke	19
Activation of astroglial CB1R mediates cerebral ischemic tolerance induced by electroacupuncture	19
A line through the brain: implementation of human line-scanning at 7T for ultra-high spatiotemporal resolution fMRI	19
Review of treatment and therapeutic targets in brain arteriovenous malformation	19
Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction	19
MRI-visible perivascular spaces in basal ganglia but not centrum semiovale or hippocampus were related to deep medullary veins changes	19
Coupling between cerebrovascular oscillations and CSF flow fluctuations during wakefulness: An fMRI study	19
A new perspective on cerebrospinal fluid dynamics after subarachnoid hemorrhage: From normal physiology to pathophysiological changes	18
Role of endothelium-pericyte signaling in capillary blood flow response to neuronal activity	18
Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult	18
Effects of O-GlcNAcylation on functional mitochondrial transfer from astrocytes	18
Hypoxemia increases blood-brain barrier permeability during extreme apnea in humans	18
[11C]deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain	18
Reliability of task-specific neuronal activation assessed with functional PET, ASL and BOLD imaging	18
The meningeal lymphatic vessels and the glymphatic system: Potential therapeutic targets in neurological disorders	18
Oligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination via Wnt/β-catenin pathway in a mouse model of middle cerebral artery occlusion	18
Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep	18
Glutamate levels and perfusion in pons during migraine attacks: A 3T MRI study using proton spectroscopy and arterial spin labeling	18
Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury	18
Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci	17
Nrf2-BDNF-TrkB pathway contributes to cortical hemorrhage-induced depression, but not sex differences	17
Remote ischemic conditioning enhances oxygen supply to ischemic brain tissue in a mouse model of stroke: Role of elevated 2,3-biphosphoglycerate in erythrocytes	17
Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition	17
In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer’s disease	17
Reliability and validity of the mean flow index (Mx) for assessing cerebral autoregulation in humans: A systematic review of the methodology	17
Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics	17
Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice	17
Metabolic underpinnings of activated and deactivated cortical areas in human brain	17
Parkinson patients have a presynaptic serotonergic deficit: A dynamic deep brain stimulation PET study	17
Reversal of neurovascular coupling in the default mode network: Evidence from hypoxia	17
Complete inhibition of ABCB1 and ABCG2 at the blood–brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib	17
Longitudinal monitoring of microglial/macrophage activation in ischemic rat brain using Iba-1-specific nanoparticle-enhanced magnetic resonance imaging	16
Effects of increased intracranial pressure on cerebrospinal fluid influx, cerebral vascular hemodynamic indexes, and cerebrospinal fluid lymphatic efflux	16
Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain	16
RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke	16
TET3 regulates DNA hydroxymethylation of neuroprotective genes following focal ischemia	16
A non-human primate model of stroke reproducing endovascular thrombectomy and allowing long-term imaging and neurological read-outs	16
Hemodynamic and structural brain measures in high and low sedentary older adults	16
A novel method of quantifying hemodynamic delays to improve hemodynamic response, and CVR estimates in CO2 challenge fMRI	16
A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models	16
Altered regional cerebral blood flow in obstructive sleep apnea is associated with sleep fragmentation and oxygen desaturation	16
Test–retest variability and reference region-based quantification of 18F-BCPP-EF for imaging mitochondrial complex I in the human brain	16
Cerebral blood flow measurements with 15O-water PET using a non-invasive machine-learning-derived arterial input function	16
Cerebral ischemia in the developing brain	16
Longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling MRI	15
Cerebral perfusion is associated with blast exposure in military personnel without moderate or severe TBI	15
Cell-specific activation of RIPK1 and MLKL after intracerebral hemorrhage in mice	15
Hemispheric CSF volume ratio quantifies progression and severity of cerebral edema after acute hemispheric stroke	15
A large portion of the astrocyte proteome is dedicated to perivascular endfeet, including critical components of the electron transport chain	15
Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy	15
Using arterial spin labeling to measure cerebrovascular reactivity in Moyamoya disease: Insights from simultaneous PET/MRI	15
CSF lipocalin-2 increases early in subarachnoid hemorrhage are associated with neuroinflammation and unfavorable outcome	15
Evaluation of [18F]-JNJ-64326067-AAA tau PET tracer in humans	15
Effect of uric acid in animal models of ischemic stroke: A systematic review and meta-analysis	15
Principles and requirements for stroke recovery science	15
Assessing cerebral arterial pulse wave velocity using 4D flow MRI	15
Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway	15
Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease	15
Pathophysiologic mechanisms of cerebral endotheliopathy and stroke due to Sars-CoV-2	15
Accumulation of PSA-NCAM marks nascent neurodegeneration in the dorsal hippocampus after neonatal hypoxic-ischemic brain injury in mice	15
Inflammation-relevant microbiome signature of the stroke brain, gut, spleen, and thymus and the impact of exercise	15
Longitudinal cortex-wide monitoring of cerebral hemodynamics and oxygen metabolism in awake mice using multi-parametric photoacoustic microscopy	15
White matter network damage mediates association between cerebrovascular disease and cognition	15
Cerebral haemodynamics with head position changes post-ischemic stroke: A systematic review and meta-analysis	14

Poor venous outflow profiles increase the risk of reperfusion hemorrhage after endovascular treatment	14
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage	14
Intracranial vessel wall lesions on 7T MRI and MRI features of cerebral small vessel disease: The SMART-MR study	14
Selective intra-carotid blood cooling in acute ischemic stroke: A safety and feasibility study in an ovine stroke model	14
Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan	14
Integrative analysis of the human brain mural cell transcriptome	14
Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis	14
Arterial elasticity, endothelial function and intracranial vascular health: A multimodal MRI study	14
Kinetics and 28-day test–retest repeatability and reproducibility of [11C]UCB-J PET brain imaging	14
Assessment of microvascular rarefaction in human brain disorders using physiological magnetic resonance imaging	14
High-altitude rodents have abundant collaterals that protect against tissue injury after cerebral, coronary and peripheral artery occlusion	14
A review of bioeffects induced by focused ultrasound combined with microbubbles on the neurovascular unit	14
Role of platelets in the pathogenesis of delayed injury after subarachnoid hemorrhage	14
Cerebroarterial pulsatility and resistivity indices are associated with cognitive impairment and white matter hyperintensity in elderly subjects: A phase-contrast MRI study	13
Impact of meningeal uptake and partial volume correction techniques on [18F]MK-6240 binding in aMCI patients and healthy controls	13
Biomechanics and hemodynamics of stent-retrievers	13
Detection of Alzheimer’s disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein	13
Systematic review: Association between circulating microRNA expression & stroke	13
Simultaneous nicotine and oral contraceptive exposure alters brain energy metabolism and exacerbates ischemic stroke injury in female rats	13
Comparative vulnerability of PET radioligands to partial inhibition of P-glycoprotein at the blood-brain barrier: A criterion of choice?	13
Cerebrovascular effects of glibenclamide investigated using high-resolution magnetic resonance imaging in healthy volunteers	13
Can oligodendrocyte precursor cells be a therapeutic target for mitigating cognitive decline in cerebrovascular disease?	13
Brain oxygen extraction fraction mapping in patients with multiple sclerosis	12
The rise of pericytes in neurovascular research	12
Protective effects of edaravone on white matter pathology in a novel mouse model of Alzheimer’s disease with chronic cerebral hypoperfusion	12
Impact of blood pressure changes in cerebral blood perfusion of patients with ischemic Moyamoya disease evaluated by SPECT	12
Cerebral metabolic rate of oxygen during transition from wakefulness to sleep measured with high temporal resolution OxFlow MRI with concurrent EEG	12
Tenascin-C induction exacerbates post-stroke brain damage	12
A functional cerebral endothelium is necessary to protect against cognitive decline	12
The impact of native leptomeningeal collateralization on rapid blood flow recruitment following ischemic stroke	12
Impaired capillary-to-arteriolar electrical signaling after traumatic brain injury	12
Cerebral endothelial cell-derived small extracellular vesicles enhance neurovascular function and neurological recovery in rat acute ischemic stroke models of mechanical thrombectomy and embolic strok	12
Noradrenaline released from locus coeruleus axons contracts cerebral capillary pericytes via α2 adrenergic receptors	12
Cerebral critical closing pressure and resistance-area product: the influence of dynamic cerebral autoregulation, age and sex	12
Metabolomic and transcriptional profiling reveals bioenergetic stress and activation of cell death and inflammatory pathways in vivo after neuronal deletion of NAMPT	12
The central role of peripheral inflammation in ischemic stroke	12
Long-term outcome of endovascular therapy for acute basilar artery occlusion	12
Differential contribution of excitatory and inhibitory neurons in shaping neurovascular coupling in different epileptic neural states	12
NMDA receptor ion channel activation detected in vivo with [18F]GE-179 PET after electrical stimulation of rat hippocampus	12
Changes in synaptic density in the subacute phase after ischemic stroke: A11C-UCB-J PET/MR study	12
Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease	12
Leptomeningeal collateral activation indicates severely impaired cerebrovascular reserve capacity in patients with symptomatic unilateral carotid artery occlusion	12