Journal of Cerebral Blood Flow and Metabolism

Article	Citations
Preconditioning with interleukin-1 alpha is required for the neuroprotective properties of mesenchymal stem cells after ischemic stroke in mice	152
Blood-brain barrier disruption imaging in postoperative cerebral hyperperfusion syndrome using DCE-MRI	82
Spreading depolarization: A wave that precedes and drives cerebral ischemic cell death—Target for neuroprotection	67
Dynamic cerebral autoregulation in people with mild cognitive impairment	65
Targeting senescence mitigates the deleterious effects of midlife obesity on neurovascular function by partially restoring blood–brain barrier integrity and neurovascular coupling	56
Targeted capillary photothrombosis via multiphoton excitation of Rose Bengal	55
Vessel architecture imaging reveals microvascular rarefaction and capillary-to-arteriole shift in cerebral small vessel disease	55
Microglia: Active participants in brain capillary function	54
Resuscitation with epinephrine worsens cerebral capillary no-reflow after experimental pediatric cardiac arrest: An in vivo multiphoton microscopy evalua	54
Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals	53
Non-invasive modelling and parametric methods for quantification of MAO-B activity using [ 11 C]L-deprenyl-D2 PET	51
Association between occlusion location, net water uptake and ischemic lesion growth in large vessel anterior circulation strokes	50
Vascular synthesis based on hemodynamic efficiency principle recapitulates measured cerebral circulation properties in the human brain	49
Sigma-1 receptor signaling: A potential therapeutic approach for ischemic stroke	48
Critical role of Slc22a8 in maintaining blood-brain barrier integrity after experimental cerebral ischemia-reperfusion	46
Stroke-induced gut microbiome dysbiosis accelerates Alzheimer’s disease progression	43
RETRACTED: CNS resident macrophages enhance dysfunctional angiogenesis and circulating monocytes infiltration in brain arteriovenous malformation	43
Exercise-induced extracellular vesicles derived from platelet-rich plasma improved recovery after ischemic stroke	41
Impact of hypertension on cerebral small vessel disease: A post-mortem study of microvascular pathology from normal-appearing white matter into white matter hyperintensities	41
Metabolic profiling and biomarker identification in idiopathic intracranial hypertension with venous sinus stenosis	39
Quantitative susceptibility mapping of the brain is associated with inflammatory changes in Alzheimer’s disease related areas	38
Post-stroke brain can be protected by modulating the lncRNA FosDT	38
Phenotypic variability in 446 CADASIL patients: Impact of NOTCH3 gene mutation location in addition to the effects of age, sex and vascular risk factors	36
Baseline CBV-normalized BOLD fMRI of visual stimulation in awake vs. anesthetized mice	36
The effect of hypercapnia on the directional sensitivity of dynamic cerebral autoregulation and the influence of age and sex	36

Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition	36
Association of cognitive function and hypoperfusion in Moyamoya disease patients without stroke	36
Brain & Brain pet 2025 Abstracts	35
Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review	35
Dynamic neuroreceptor positron emission tomography in non-anesthetized rats using point source based motion correction: A feasibility study with [ 11	33
Temperature dysregulation during therapeutic hypothermia predicts long-term outcome in neonates with HIE	32
Post cardiac arrest physical exercise mitigates cell death in the septal and thalamic nuclei and ameliorates contextual fear conditioning deficits in rats	32
Amyloid beta peptides inhibit glucose transport at the blood-brain barrier by disrupting the insulin-AKT pathway	31
EXPRESSION OF CONCERN: Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matr	31
Pathological changes of brain oscillations following ischemic stroke	31
Plasminogen activator inhibitor-1 mediates cerebral ischemia-induced astrocytic reactivity	30
Nogo-A is secreted in extracellular vesicles, occurs in blood and can influence vascular permeability	30
RNF213 variant and autophagic impairment: A pivotal link to endothelial dysfunction in moyamoya disease	30
Ironing out mechanisms of ferroptotic death to tailor new stroke therapies	29
Role of pterygopalatine ganglion in regulating isoflurane-induced cerebral hyper-perfusion	29
Macrovascular blood flow and microvascular cerebrovascular reactivity are regionally coupled in adolescence	28
Co-transplantation of autologous treg cells: A groundbreaking cell therapy for brain diseases	27
A systematic review and in silico analysis of studies investigating the ischemic penumbra proteome in animal models of experimental stroke	26
Disturbed microcirculation and hyperaemic response in a murine model of systemic inflammation	26
Elucidating stroke etiology through lipidomics of thrombi and plasma in acute ischemic stroke patients undergoing endovascular thrombectomy	26
Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke	26
NK1 tachykinin receptor antagonist treatment reduces cerebral edema and intracranial pressure in an ovine model of ischemic stroke	26
Endothelial progenitor cell transplantation attenuates synaptic loss associated with enhancing complement receptor 3-dependent microglial/macrophage phagocytosis in ischemic mice	26
Characterizing pre- and post-operative cerebral blood flow and transit time in pediatric moyamoya patients using multi-delay ASL and DSC MRI	25
Characteristics of activation of monocyte-derived macrophages versus microglia after mouse experimental intracerebral hemorrhage	25
EXPRESS: Meningeal CSF transport varies across parasagittal dura subregions with age in humans	24
Thank you to reviewers	24
Reversible edema after radiosurgery for arteriovenous malformations (AVMs): Inflow and outflow imbalance	24
Effect and mechanisms of resveratrol in animal models of ischemic stroke: A systematic review and Bayesian meta-analysis	24
Incidence, severity and impact on functional outcome of persistent hypoperfusion despite large-vessel recanalization, a potential marker of impaired microvascular reperfusion: Systematic review of the	24
Inactivation of BACE1 increases expression of endothelial nitric oxide synthase in cerebrovascular endothelium	24
Magnetic resonance imaging indices for early Alzheimer’s disease detection: Brain clearance markers	24
Non-invasive [ 15 O]H 2 O PET measurements of cerebral perfusion and cerebrovascular reactivity us	23
Measuring capillary flow dynamics using interlaced two-photon volumetric scanning	23
Statistical non-independence of brain metabolite concentrations whether normalized to creatine or water	23
Transcriptome analyses of brain arteries and microvessels in male and female mice reveal prominent olfactory receptor gene and protein expression	23
Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI	23
Genetics of intracerebral hemorrhage	23
Cerebrovascular morphology: Insights into normal variations, aging effects and disease implications	23
Cerebral O 2 and CO 2 transport in isovolumic haemodilution: Compensation of cerebral delivery of	23
Multimodal and serial MRI monitors brain peri-hematomal injury and repair mechanisms after experimental intracerebral hemorrhage	22
Reliable infarction of the middle cerebral artery territory in C57BL/6 mice using pterygopalatine artery ligation and filament optimization – The PURE-MCAo model	22
A new framework for metabolic connectivity mapping using bolus [ 18 F]FDG PET and kinetic modeling	22
Association between time-dependent changes in cerebrovascular autoregulation after cardiac arrest and outcomes: A prospective cohort study	22
Brain water dynamics across sleep stages measured by near-infrared spectroscopy: Implications for glymphatic function	22
The immediate functional and structural consequences of head-down tilt on the cranial venous vasculature and brain temperature	22
Cerebral multi-autoregulation model based enhanced external counterpulsation treatment planning for cerebral ischemic stroke	22
Capillaries susceptible to frequent stall dynamics revealed by comparing OCT and bessel-2PM measurements	22
Cerebral blood flow alterations and host genetic association in individuals with long COVID: A transcriptomic-neuroimaging study	22
Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan	21

Hemoglobin and cerebral hypoxic vasodilation in humans: Evidence for nitric oxide-dependent and S -nitrosothiol mediated signal transduction	21
Quantification of the purinergic P2X 7 receptor with [ 11 C]SMW139 improves through correction for	21
Targeting seryl-tRNA synthetase to unlock ischemic resilience in stroke – Insights from a proof-of-concept study	21
Spatiotemporal analysis of blood plasma and blood cell flow fluctuations of cerebral microcirculation in anesthetized rats	21
Where and how do leukocytes stall in retinal microcirculation: A spatiotemporal analysis with a focus on junctions and pericytes	21
Preliminary investigations into human neurofluid transport using multiple novel non-contrast MRI methods	20
Impaired dynamic cerebral autoregulation predicts silent ischemic lesions after carotid artery stenting: A hemodynamic biomarker beyond plaque morphology	20
Micro-ultrasound based characterization of cerebrovasculature following focal ischemic stroke and upon short-term rehabilitation	20
A lone spike in blood glucose can enhance the thrombo-inflammatory response in cortical venules	20
Characterizing the protective vasodilatory effects of hypobaric hypoxia on the neurovascular coupling response	20
Predictive value of cerebrovascular time constant for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage	20
Rapid, selective and homogeneous brain cooling with transnasal flow of ambient air for pediatric resuscitation	20
Genetic, vascular and amyloid components of cerebral blood flow in a preclinical population	20
High-resolution vasomotion analysis reveals novel arteriole physiological features and progressive modulation of cerebral vascular networks by stroke	20
Sex modifies the relationship between age and neurovascular coupling in healthy adults	19
Thanks to Reviewers	19
Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach	19
Increased peripheral leukocyte aggravates brain injury and leads to poor outcome in stroke patients receiving intravenous thrombolysis: A study based on clinical evidence	19
Commentary to “Ischemic conditioning promotes transneuronal survival and stroke recovery via CD36-mediated efferocytosis”	19
Two possible hemodynamic mechanisms underlying the growth of cerebral aneurysms depending on their size: The NHO CFD ABO study	19
Quantitation of regional distribution of antibodies in rat brain following systemic and intra-CNS administration	19
Focused ultrasound opens the blood–brain barrier and reveals an age-dependent dissociation between resting cerebral blood flow and neurovascular coupling	18
Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury	18
Advances in three-dimensional modeling of ischemic injury	18
Hyperoxia evokes pericyte-mediated capillary constriction	18
Unlocking the potential of photobiomodulation therapy for brain neurovascular coupling: The biological effects and medical applications	17
Cerebral arterial stiffness is linked to white matter hyperintensities and perivascular spaces in older adults – A 4D flow MRI study	17
Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI	17
Type 2 diabetes abates retrograde collateral flow and promotes leukocyte adhesion following ischemic stroke	17
Multifaceted neural and vascular pathologies after pediatric mild traumatic brain injury	17
Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders	17
Targeted proteomic analysis identifies ACVRL1 as a marker of cerebral edema in aneurysmal subarachnoid hemorrhage	17
Assessing the effects of aging on the Koizumi’s and Zea Longa’s methods and their suitability as mouse models for evaluating neurodegeneration post-ischemic stroke: A comparative study	17
The age-associated decline in neuroplasticity and its implications for post-stroke recovery in animal models of cerebral ischemia: The therapeutic role of extracellular vesicles	17
In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging	17
β -hydroxybutyrate enhances brain metabolism in normoglycemia and hyperglycemia, providing cerebroprotection in a mouse stroke model	16
Systematic review and meta-analysis of cognitive assessments used to detect deficits in the bilateral carotid artery stenosis model for vascular cognitive impairment	16
A novel model to quantify blood transit time in cerebral arteries using ASL-based 4D magnetic resonance angiography with example clinical application in moyamoya disease	16
Mild hypercapnia before reperfusion reduces ischemia-reperfusion injury in hyperacute ischemic stroke rat model	16
Protective and pathogenic: The Janus-faced role of cGAS–STING in the brain	16
Lactate accumulates in the cerebrospinal fluid after prolonged exercise	16
Metabolic implications of axonal demyelination and its consequences for synchronized network activity: An in silico and in vitro	16
Unique expression of the atypical mitochondrial subunit NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response to hypoxia	16
Prophylactic PDE4 and PDE4B inhibition reduce lesion size and neutrophil infiltration following ischemic stroke in male mice	16
Associations of life-course cardiovascular risk factors with late-life cerebral hemodynamics	16
Kinetic modeling of the monoamine oxidase-B radioligand [ 18 F]SMBT-1 in human brain with positron emission tomography	16
Using human genomics to validate drug targets for acute ischemic stroke	15
Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke	15
Extracellular vesicles lay the ground for neuronal plasticity by restoring mitochondrial function, cell metabolism and immune balance	15
Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease	15
Vascular determinants of hippocampal viscoelastic properties in healthy adults across the lifespan	15
Neurovascular coupling in early stage dementia – A case-control study	15
Cerebral blood flow adaptations following 90 days head-down bed rest: Evidence from pseudo-continuous arterial spin labeling magnetic resonance imaging	14
Commentary to Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke	14
Zfp580 inactivation as a new therapeutic target to enhance recovery after stroke in mice	14
Treatment for moyamoya disease with hyperhomocysteinemia	14
Neural stem cell transplantation attenuates cognitive decline and neuroinflammation in a mouse model of Alzheimer’s disease with chronic cerebral hypoperfusion	14
Reversal of the detrimental effects of social isolation on ischemic cerebral injury and stroke-associated pneumonia by inhibiting small intestinal γδ T-c	14
H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1	14
Non-classical monocytes promote neurovascular repair in cerebral small vessel disease associated with microinfarctions via CX3CR1	14
Effect of the duration of hypertension on white matter structure and its link with cognition	14
Control of neurovascular coupling by ATP-sensitive potassium channels	14
Global, regional and national burden of ischemic stroke attributed to high low-density lipoprotein cholesterol, 1990–2019：A decomposition analysis and age-period-cohort analysis	14
Brain-targeted mild hypothermia ameliorates ischemic brain injury and promotes stroke recovery in aged mice	14
Neuropathological correlates of MRI-observed hypointense lesions in the APP23 mouse model of cerebral amyloid angiopathy	14
Antihypertensives in dementia: Good or bad for the brain?	14
How processing choices effect repeatability in BOLD–CVR imaging	14
Calcium transients in nNOS neurons underlie distinct phases of the neurovascular response to barrel cortex activation in awake mice	14
Microglial histone deacetylase 2 is dispensable for functional and histological outcomes in a mouse model of traumatic brain injury	14
A dangerous liaison: Spreading depolarization and tissue acidification in cerebral ischemia	14
Neural and vascular contributions to sensory impairments in a human alpha-synuclein transgenic mouse model of Parkinson’s disease	13
Pharmacological modulation of circadian rhythms in brain microvasculature	13
Exploring brain glucose metabolism in multiple sclerosis: A deuterium metabolic imaging study	13
Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain	13
Targeting angiogenesis and white matter repair for enhanced functional recovery after acute ischemic stroke: A focus on the roles of glial cells	13
Point-Counterpoint: Cerebral perfusion pressure is a high-risk concept	13
A novel approach for modeling in vivo enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase	13
Posterior communicating artery variation is linked to compromised cerebral hemodynamics in middle-aged and older adults	13
Systematic review and meta-analysis of transcranial doppler biomarkers for the prediction of delayed cerebral ischemia following subarachnoid hemorrhage	13
EXPRESS: Heightened respiratory brain pulsations indicate fluid dynamic dysfunction in early multiple sclerosis	13

Leukocyte indicators and variations predict worse outcomes after intravenous thrombolysis in patients with acute ischemic stroke	13
A systematic observation of vasodynamics from different segments along the cerebral vasculature in the penumbra zone of awake mice following cerebral ischemia and recanalization	13
Cerebral ischemia in the developing brain	13
Ischemic core reversal on neuroimaging following endovascular reperfusion: A systematic review and meta-analysis	13
The miR-451a facilitates natural killer cell-associated immune deficiency after ischemic stroke	13
EXPRESS: Single-tracer [ 18 F]FDG PET quantification of blood-brain barrier permeability and cerebral blood flow: Validation using dual-tracer PET	13
Predicting brain temperature in humans using bioheat models: Progress and outlook	13
Correcting SUVR bias by accounting for radiotracer clearance in tissue: A validation study with [ 18 F	12
Time matters: Circadian effects on stroke pathophysiology	12
Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review	12
A reference-based PET/MRI method for quantifying activation-induced changes in cerebral oxygen metabolism	12
Diesel exhaust particles exposure exacerbates pro-thrombogenic plasma features ex-vivo after cerebral ischemia and accelerates tPA-induced clot-lysis in	12
High-physiological and supra-physiological 1,2- 13 C 2 glucose focal supplementation to the trauma	12
“No-reflow” phenomenon in acute ischemic stroke	12
DPSCs-Exos promote OPCs differentiation and white matter repair via Myl9-mediated PRMT5 nucleation after ischemic stroke	12
Vascular topology and blood flow are acutely impacted by experimental febrile status epilepticus	12
Acute psilocybin and ketanserin effects on cerebral blood flow: 5-HT2AR neuromodulation in healthy humans	12
The relationship between cytochrome c oxidase, CBF and CMRO 2 in mouse cortex: A NIRS-MRI study	12
Comparison of approaches for surface vessel diameter and pulsatility quantification	12
Post-endovascular treatment gyral hyperdensity sign: A warning sign preceding malignant cerebral edema in ischemic stroke	12
Sensitivity assessment of QSM+qBOLD (or QQ) in detecting elevated oxygen extraction fraction (OEF) in physiological change	12
An automatic analysis framework for FDOPA PET neuroimaging	11
Endothelial energy failure as a therapeutic target in elderly strokes	11
Airborne particulates and brain health: The role of PM 2.5 in blood-brain-barrier dysfunction	11
Alpha-adrenergic receptor activation after fetal hypoxia-ischaemia suppresses transient epileptiform activity and limits loss of oligodendrocytes and hippocampal neurons	11
Quantification of brain-wide vascular resistivity via ultrafast Doppler in human neonates helps early detection of white matter injury	11
Metformin attenuates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion	11
Insulin-stimulated brain glucose uptake correlates with brain metabolites in severe obesity: A combined neuroimaging study	11
Growth arrest specific protein 6 alleviated white matter injury after experimental ischemic stroke	11
EXPRESS: A perivascular perspective on the immune impacts in cerebral amyloid angiopathy	11
Contribution of extracerebral tracer retention and partial volume effects to sex differences in Flortaucipir-PET signal	11
Superior sagittal sinus flow as a proxy for tracking global cerebral blood flow dynamics during wakefulness and sleep	11
Antihypertensives in dementia: Good or bad for the brain?	11
A plasma lipid signature in acute human traumatic brain injury: Link with neuronal injury and inflammation markers	11
Role of miRNAs in neurovascular injury and repair	11
Accurate and fully automated diameter measurements of Circle of Willis arteries on MRA imaging	11
Pretreatment with oleuropein protects the neonatal brain from hypoxia-ischemia by inhibiting apoptosis and neuroinflammation	11
Neutrophil-derived cathelicidin promotes cerebral angiogenesis after ischemic stroke	11
Delayed administration of type II ampakines enhance synaptic plasticity and cognitive recovery in juvenile global cerebral ischemia	10
Erythropoietin preserves outer blood–retinal barrier integrity in diabetic retinopathy via AMPK-dependent autophagy and Nrf2 signaling	10
Optimal filtering strategies for task-specific functional PET imaging	10
Editorial to the special issue on extracellular vesicles and mitochondria in CNS function and disease	10
Modification of cerebrovascular morphologies during different stages of life	10
Associations between admission levels of multiple biomarkers and subsequent worse outcomes in acute ischemic stroke patients	10
Aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and Alzheimer’s disease	10
Fecal microbiota transplantation fails to impart the benefits of circadian-dependent intermittent fasting following ischemic stroke	10
Cannabinoid 1 receptor occupancy and neurovascular responses induced by agonist, antagonist/inverse-agonist and potential modulator in non-human primate brains: PET/fMRI study	10
Imaging the 5-HT 2C receptor with PET: Evaluation of 5-HT 2C and 5-HT 2A<	10
Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but may regulate neurorepair processes after experimental ischemic stroke	10
Static and dynamic BOLD fMRI components along white matter fibre tracts and their dependence on the orientation of the local diffusion tensor axis relative to the B 0	10
Retinal microvascular phenotypes can track small vessel disease burden and CPAP treatment effectiveness in obstructive sleep apnea	10
Activation of acid-sensing ion channels contributes to the hypercapnia-induced neurovascular response in the neonatal cerebral cortex	10
A unified approach for identifying PET-based neuronal activation and molecular connectivity with the functional PET toolbox	10
Type-1-to-type-2 transition of brain microvascular pericytes induced by cytokines and disease-associated proteins: Role in neuroinflammation and blood-brain barrier disruption	10
Isoform-selective and non-selective rho-kinase inhibitors do not affect collagenase-induced intracerebral hemorrhage outcomes in mice: Influence of sex and circadian cycle	10
Unveiling m7G modification patterns and causal drivers governing intracranial aneurysm rupture risk through multi-omics validation and m7G-MeRIP-seq profiling	10
Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke	10
A systematic review, meta-analysis and meta-regression amalgamating the driven approaches used to quantify	10
Direct glia-to-neuron conversion mitigates hippocampal damage in a vascular dementia mouse model	10