OOIR: Observatory of International Research

Papers

(The TQCC of Drug Development Research is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Novel matrinic acid derivatives bearing 2‐anilinothiazole structure for non‐small cell lung cancer treatment with improved Hsp90 targeting effect	83
Trifolirhizin targets PTK6 to induce autophagy and exerts antitumor effects in nasopharyngeal carcinoma	70
Safety study of topical naltrexone therapy for diabetic skin wounds is confirmed in Göttingen mini‐pigs	59
Research Progress of Endoplasmic Reticulum Targeting Metal Complexes in Cancer Therapy	51
Susceptibility of Leishmania to novel pentavalent organometallics: Investigating impact on DNA and membrane integrity in antimony(III)‐sensitive and ‐resistant strains	46
Bioinformatics Exploration of the Therapeutic Potential of Lotus Seed Compounds in Multiple Sclerosis: A Network Analysis of c‐Jun Pathway	45
A growth‐based assay using fluorescent protein emission to screen for S‐adenosylmethionine synthetase inhibitors	45
Design, synthesis, in vitro, and in vivo evaluation of novel phthalazinone‐based derivatives as promising acetylcholinesterase inhibitors for treatment of Alzheimer's disease	43
Terbutaline attenuates LPS ‐induced injury of pulmonary microvascular endothelial cells by cAMP /Epac signaling	40
CircRNF121 knockdown suppresses the progression of cervical cancer by regulating miR ‐153‐3p/ ATF2 axis and	36
Targeting TRAF3IP2 alleviates high glucose‐induced cardiomyocyte inflammation and apoptosis	36
Knockdown of IGF2BP3 inhibits the tumorigenesis of gallbladder cancer and modifies tumor microenvironment	29
Issue Information	26
T‐17, a novel cyclin‐dependent kinases/histone deacetylases dual inhibitor, induces cancer cells death through cell cycle arrest and apoptosis	26
Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases	26
Issue Information	26
Therapeutic potential and research progress of diosgenin for lipid metabolism diseases	26
PX‐12 synergistically enhances the therapeutic efficacy of vorinostat under hypoxic tumor microenvironment in oral squamous cell carcinoma in vitro	25
Ricolinostat suppresses proliferation, promotes apoptosis, and enhances the antiproliferative activity of topoisomerase inhibitors in cervical cancer cells	24
New pyrrole derivatives as DNA gyrase and 14α‐demethylase inhibitors: Design, synthesis, antimicrobial evaluation, and molecular docking	22
RecQ protein‐like 4 drives cisplatin chemosensitivity of cervical cancer cells by modulating annexin A2	21
Does Metabolic Manager Show Encouraging Outcomes in Alzheimer's?: Challenges and Opportunity for Protein Tyrosine Phosphatase 1b Inhibitors	21
The recent development of thymol derivative as a promising pharmacological scaffold	20
Issue Information	20
Synthesis, characterization, molecular modeling studies, and biological evaluation of metal piroxicam complexes (M = Ni(II), Pt(IV), Pd(II), Ag(I)) as antibacterial and anticancer agents	19

Recent advancement in drug development of nitro(NO₂)‐heterocyclic compounds as lead scaffolds for the treatment of Mycobacterium tuberculosis	19
Reduction‐Responsive RGD‐Docetaxel Conjugate: Synthesis, In Vitro Drug Release and In Vitro Antitumor Activity	19
Recent research brings hope for reshaping the co‐evolutionary arms race against parasitic infectious diseases	19
Diaryl Diimidazopyrimidine Derivatives as Potent Inhibitors of Influenza A Virus: Synthesis, Evaluation and Docking Studies	19
Dendrobine modulates autophagy to alleviate ox‐LDL‐induced oxidative stress and senescence in HUVECs	18
Recombinant human epidermal growth factor‐loaded liposomes and transferosomes for dermal delivery: Development, characterization, and cytotoxicity evaluation	18
Repurposing Nitroimidazoles: A New Frontier in Combatting Bacterial Virulence and Quorum Sensing via In Silico, In Vitro, and In Vivo Insights	18
Propofol promotes migration, alleviates inflammation, and apoptosis of lipopolysaccharide‐induced human pulmonary microvascular endothelial cells by activating PI3K/AKT signaling	18
The potential of developing a protective peptide‐based vaccines against SARS‐CoV‐2	17
Tropisetron attenuates high glucose‐induced oxidative stress and inflammation in ARPE‐19 cells in vitro via regulating SIRT1/ROCK1 signaling	17
Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway	17
Xanthatin induce DDP‐resistance lung cancer cells apoptosis through regulation of GLUT1 mediated ROS accumulation	17
Toosendanin inhibits colorectal cancer cell growth through the Hedgehog pathway by targeting Shh	17
Effective and transient mapping of protein–protein interactions: Application of novel releasable photoaffinity linkers	16
Molecular Pathways in Idiopathic Pulmonary Fibrosis: A Review of Novel Insights for Drug Design	16
An Inducible Neural Stem Progenitor Cell Model for Testing Therapeutic Interventions Against Neurodegeneration FENIB	16
Sm(Ⅲ), Gd(Ⅲ), and Eu(Ⅲ) complexes with 8‐hydroxyquinoline derivatives as potential anticancer agents via inhibiting cell proliferation, blocking cell cycle, and inducing apoptosis in NCI‐H460 cells	16
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin‐4(3H)‐one derivatives as potential aldose reductase inhibitors	16
⁶⁸Ga‐labeled, imatinib encapsulated, theranostic liposomes: Formulation, characterization, and in vitro evaluation of anticancer activity	16
Issue Information	16
Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors	16
Paeonol inhibits chronic constriction injury‐induced astrocytic activation and neuroinflammation in rats via the HDAC/miR‐15a pathway	16
In Vitro and In Silico Assessment of Antileishmanial Potential of Novel Tri‐ and Penta‐Valent Antimony Complexes With Phenolic Ligands	16
Design, synthesis, and in‐silico study of novel triarylethylene analogs with dual anti‐estrogenic and serotonergic activity	15
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Bazedoxifene analogs as potential WDHD1 degraders and antitumor agents: Synthesis, evaluation and molecular dynamics simulation studies	15
Toad venom bufadienolides and bufotoxins: An updated review	15
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Synthetic amino acids‐based short amphipathic peptides exhibit antifungal activity by targeting cell membrane disruption	15
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Upregulation of FGF9 and NOVA1 in cancer‐associated fibroblasts promotes cell proliferation, invasion and migration of triple negative breast cancer	15
Hirudin attenuates puromycin aminonucleoside‐induced glomerular podocyte injury by inhibiting MAPK‐mediated endoplasmic reticulum stress	14
Costunolide attenuates high‐fat diet‐induced inflammation and oxidative stress in non‐alcoholic fatty liver disease	14
⁸⁹Zr‐Labeled DFO@Durvalumab‐HSA nanoparticles: In vitro potential for triple‐negative breast cancer	14
New Ester‐Containing Azole Derivatives With Potent Anti‐Candida Effects: Synthesis, Antifungal Susceptibility, Cytotoxicity, and Molecular Modeling Studies	14
Issue Information	13
Conventional and microwave‐assisted organic synthesis of novel antimycobacterial agents bearing furan and pyridine hybrids	13
Imidazolidine‐Based Aspartate Inhibitors for Candida Infections	13
Selective carbonic anhydrase IX and XII inhibitors based around a functionalized coumarin scaffold	13
CircTHBS1 facilitates the progression of interstitial cystitis depending on the regulation of miR‐139‐5p/MFN2 axis	13
Issue Information	12
Therapeutic role of Artemether in the prevention of hepatic steatosis through miR‐34a‐5p/PPARα pathway	12
Everolimus inhibits hepatoblastoma by inducing autophagy‐dependent ferroptosis	12
FDA Modernization Act 2.0: An insight from nondeveloping country	12
Design and Discovery of New Dual Carbonic Anhydrase IX and VEGFR‐2 Inhibitors Based on the Benzenesulfonamide‐Bearing 4‐Thiazolidinones/2,4‐Thiazolidinediones Scaffold	12
Medicinal chemistry of anthranilic acid derivatives: A mini review	12
Formulation characterization of lecithin organogel as topical drug delivery system for psoriasis: In‐vitro permeation and preclinical evaluation	12
Synthesis, biological evaluation, and in silico studies of indole‐tethered pyrazoline derivatives as anticancer agents targeting topoisomerase IIα	12
Nitroimidazole derivatives potentiated against tumor hypoxia: Design, synthesis, antitumor activity, molecular docking study, and QSAR study	11
Road‐map of pre‐clinical treatment for Visceral Leishmaniasis	11

A quinazoline‐based bromodomain inhibitor, CN210, ameliorates indomethacin‐induced ileitis in mice by inhibiting inflammatory cytokine expression	11
A new exploration toward adamantane derivatives as potential anti‐MDR agents: Design, synthesis, antimicrobial, and radiosterilization activity as potential topoisomerase IV and DNA gyrase inhibitors	11
Allosteric modulation of SHP2: Quest from known to unknown	11
Antibacterial and anti‐inflammatory activity of valproic acid‐pyrazole conjugates as a potential agent against periodontitis	11
β_lactam antibiotics against drug addiction: A novel therapeutic option	11
Proteolysis Targeting Chimera (PROTAC) as a promising novel therapeutic modality for the treatment of triple‐negative breast cancer (TNBC)	10
Carbamate as a potential anti‐Alzheimer's pharmacophore: A review	10
A novel copper chelator for the suppression of colorectal cancer	10
Hesperidin, vanillic acid, and sinapic acid attenuate atorvastatin‐induced mitochondrial dysfunction via inhibition of mitochondrial swelling and maintenance of mitochondrial function in pancreas isol	10
Circular RNAs in the chemoresistance of triple‐negative breast cancer: A systematic review	10
Fluorinated Sulfonamides: Synthesis, Characterization, In Silico, Molecular Docking, ADME, DFT Predictions, and Structure‐Activity Relationships, as Well as Assessments of Antimicrobial and Ant	10
Races of small molecule clinical trials for the treatment of COVID‐19: An up‐to‐date comprehensive review	10
Rutin increases alpha‐tubulin acetylation via histone deacetylase 6 inhibition	10
Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis	10
Investigation of the factors responsible for the low oral bioavailability of alizarin using a sensitive LC‐MS/MS method: In vitro, in situ, and in vivo evaluations	10
Discovery of pyrazole‐carbohydrazide with indole moiety as tubulin polymerization inhibitors and anti‐tumor candidates	10
Deciphering chemoresistance in osteosarcoma: Unveiling regulatory mechanisms and function through the lens of noncoding RNA	10
Sodium tanshinone IIA sulfonate promotes spinal cord injury repair by inhibiting blood spinal cord barrier disruption in vitro and in vivo	10
Xanthatin inhibits non‐small cell lung cancer proliferation by breaking the redox balance	10
RETRACTION: “Dose‐dependent Chemopreventive Effects of Citronellol in DMBA‐Induced Breast Cancer Among Rats”	9
Comprehensive characterization and preclinical assessment of an imidazopyridine‐based anticancer lead molecule	9
Design and synthesis of novel tetrabromophthalimide derivatives as potential tubulin inhibitors endowed with apoptotic induction for cancer treatment	9
Structural Diversity and Mutational Challenges of Toll‐Like Receptor 4 Antagonists as Inflammatory Pathway Blocker	9
Pyridazine derivatives as selective COX‐2 inhibitors: A review on recent updates	9
Evaluation of geranylgeranyl diphosphate synthase inhibition as a novel strategy for the treatment of osteosarcoma and Ewing sarcoma	9
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Quercetin ameliorates salivary gland apoptosis and inflammation in primary Sjögren's syndrome through regulation of the leptin/OB‐R signaling	9
Pantoprazole suppresses carcinogenesis and growth of hepatocellular carcinoma by inhibiting glycolysis and Na⁺/H⁺ exchange	9
Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies	9
Explore new quinoxaline pharmacophore tethered sulfonamide fragments as in vitro α‐glucosidase, α‐amylase, and acetylcholinesterase inhibitors with ADMET and molecular modeling simulation	9
The Role of Fatty Acid Metabolism, the Related Potential Biomarkers, and Targeted Therapeutic Strategies in Gastrointestinal Cancers	9
Xanthatin inhibits human colon cancer cells progression via mTOR signaling mediated energy metabolism alteration	9
Tetrahydropalmatine induces the polarization of M1 macrophages to M2 to relieve limb ischemia‐reperfusion‐induced lung injury via inhibiting the TLR4/NF‐κB/NLRP3 signaling pathway	9
9‐Ethynyl noscapine induces G2 /M arrest and apoptosis by disrupting tubulin polymerization in cervical cancer	9
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Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management	8
Verbascoside enhances radiosensitivity of hepatocellular carcinoma cells through regulating miR‐101‐3p/Wee1 axis	8
Retraction	8
Enriching iPSC research diversity: Harnessing human biobank collections for improved ethnic representation	8
Identification of ROS and KEAP1‐related genes and verified targets of α‐hederin induce cell death for CRC	8
YTHDF2 interference suppresses the EMT of cervical cancer cells and enhances cisplatin chemosensitivity by regulating AXIN1	8
YTHDF2 promotes gastric cancer progression and enhances chemoradiotherapy resistance	8
Issue Information	8
Design and synthesis of novel hexahydrobenzo[4,5]thieno[2,3‐d]pyrimidine derivatives as potential anticancer agents with antiangiogenic activity via VEGFR‐2 inhibition, and down‐regulation of P	8
Synthesis and anti‐HIV activity of non‐nucleoside reverse‐transcriptase inhibitor DB02 phosphate derivatives based on water‐soluble optimization	8
A novel cinnamic and caffeic acid‐conjugated peptide analogs with anticonvulsant and analgesic potency: Comparative analyses of trans/cis isomers	8
Discovery of 4‐(4‐aminophenyl)‐6‐phenylisoxazolo[3,4‐b]pyridine‐3‐amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia	8
Fasudil attenuates syncytin‐1‐mediated activation of microglia and impairments of motor neurons and motor function in mice	8
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The cytotoxicity of karanjin toward breast cancer cells is involved in the PI3K/Akt signaling pathway	8
Structure and activity of ananti‐epidermal growth factor receptor antibody without galactose‐α‐1,3‐galactose residues	8
Schisandrin B ameliorates non‐alcoholic liver disease through anti‐inflammation activation in diabetic mice	8
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR‐144‐3p/IGF2R axis	8
TRPM2‐AS promotes paclitaxel resistance in prostate cancer by regulating FOXK1 via sponging miR‐497‐5p	8
Cover Image, Volume 85, Issue 1	8
Design, synthesis, in silico, and in vitro evaluation of novel benzyloxybenzene substituted (S)‐α‐amino amide derivatives as cholinesterases and monoaminoxidases inhibitor	8
Papaverine, a promising therapeutic agent for the treatment of COVID‐19 patients with underlying cardiovascular diseases (CVDs)	8
Design and synthesis of vancomycin‐functionalized ZnFe₂O₄ nanoparticles as an effective antibacterial agent against methicillin‐resistant Staphylococcus aureus	8
Discovery of pyrazole‐1‐carboxamide derivatives as novel Gi‐biased μ‐opioid receptor agonists	8
Combined chemotherapy of zoledronic acid and pamidronate in the treatment of bone metastases from nonsmall cell lung cancer and the effects on pain stress and bone metabolic indices	7
Downregulation of short‐stature homeobox protein 2 suppresses gastric cancer cell growth and stemness in vitro and in vivo via inactivating wnt/β‐catenin signaling	7
Chitosan‐coated nanoparticles in innovative cancer bio‐medicine	7
Role of BIX01294 in the intracranial inhibition of H3K9 methylation lessens neuronal loss in vascular dementia model	7
Exploring the potential of radiolabeled duramycin as an infection imaging probe	7
Evaluation of advanced, pathophysiologic new targets for imaging of CNS	7
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CircATL2 enhances paclitaxel resistance of ovarian cancer via impacting miR‐506‐3p/NFIB axis	7
Issue Information	7
Quercetin regulates vascular endothelium function in chronic renal failure via modulation of Eph/Cav‐1 signaling	7
Protective effect of thymoquinone nanoemulsion in reducing the cardiotoxic effect of 5‐fluorouracil in rats	7
Computational and experimental analyses of alanine racemase suggest new avenues for developing allosteric small‐molecule antibiotics	7
Unraveling the Curcumin's Molecular Targets and Its Potential in Suppressing Skin Inflammation Using Network Pharmacology and In Vitro Studies	7
Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development	7
Issue Information	7
Cover Image, Volume 83, Issue 7	7