Drug Development Research

Article	Citations
Androgen sensitivity gateway to COVID‐19 disease severity	118
Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID‐19	69
Potential antiviral activity of isorhamnetin against SARS‐CoV‐2 spike pseudotyped virus in vitro	51
Epigallocatechin gallate and theaflavin gallate interaction in SARS‐CoV‐2 spike‐protein central channel with reference to the hydroxychloroquine interaction: Bioinformatics and molecular do	43
Surface receptor‐mediated targeted drug delivery systems for enhanced cancer treatment: A state‐of‐the‐art review	43
Challenges of peptide and protein drug delivery by oral route: Current strategies to improve the bioavailability	41
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin‐4(3H)‐one derivatives as potential aldose reductase inhibitors	39
Role of mineralocorticoid receptor antagonists in kidney diseases	38
Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release	32
Medicinal chemistry of anthranilic acid derivatives: A mini review	29
Revisiting potential druggable targets against SARS‐CoV‐2 and repurposing therapeutics under preclinical study and clinical trials: A comprehensive review	28
Snake venom‐derived bradykinin‐potentiating peptides: A promising therapy for COVID‐19?	26
Bergenin inhibits bladder cancer progression via activating the PPARγ/PTEN/Akt signal pathway	25
Paeoniflorin inhibited nod‐like receptor protein‐3 inflammasome and NF‐κB‐mediated inflammatory reactions in diabetic foot ulcer by inhibiting the chemokine receptor CXCR2	25
In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities with molecular modeling	24
Hybrid molecules based on 1,3,5‐triazine as potential therapeutics: A focused review	24
Neuroprotective mechanisms of mangiferin in neurodegenerative diseases	23
In vitro–in vivo evaluation of tetrahydrozoline‐loaded ocular in situ gels on rabbits for allergic conjunctivitis management	22
Smoking and COVID‐19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokers	22
Review of registered clinical trials for the treatment of COVID‐19	22
Ginsenoside Rg3 attenuates ovariectomy‐induced osteoporosis via AMPK/mTOR signaling pathway	22
A new exploration toward adamantane derivatives as potential anti‐MDR agents: Design, synthesis, antimicrobial, and radiosterilization activity as potential topoisomerase IV and DNA gyrase inhibitors	22
Targeting cyclooxygenase enzyme for the adjuvant COVID‐19 therapy	22
CB2 receptor‐selective agonists as candidates for targeting infection, inflammation, and immunity in SARS‐CoV‐2 infections	21
Estradiol reduces ACE2 and TMPRSS2 mRNA levels in A549 human lung epithelial cells	21

Osteoarthritis: Prognosis and emerging therapeutic approach for disease management	21
Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line	20
An appraisal of anticancer activity with structure–activity relationship of quinazoline and quinazolinone analogues through EGFR and VEGFR inhibition: A review	20
Overview of in situ gelling injectable hydrogels for diabetic wounds	20
Therapeutic potential of targeting the receptor for advanced glycation end products (RAGE) by small molecule inhibitors	19
Novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors	18
Investigation of antioxidant and anti‐nociceptive potential of isoxazolone, pyrazolone derivatives, and their molecular docking studies	18
Phytochemical conjugation as a potential semisynthetic approach toward reactive and reuse of obsolete sulfonamides against pathogenic bacteria	18
Paeonol protects melanocytes against hydrogen peroxide‐induced oxidative stress through activation of Nrf2 signaling pathway	18
Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review	17
Superiority of cilostazol among antiplatelet FDA‐approved drugs against COVID 19 Mpro and spike protein: Drug repurposing approach	17
Drug encapsulating polysaccharide‐loaded metal nanoparticles: A perspective drug delivery system	17
Proteolysis targeting chimera (PROTAC) for epidermal growth factor receptor enhances anti‐tumor immunity in non‐small cell lung cancer	17
A review on synthetic strategy, molecular pharmacology of indazole derivatives, and their future perspective	17
Design, synthesis, in vitro and in silico studies of novel Schiff base derivatives of 2‐hydroxy‐4‐methoxybenzamide as tyrosinase inhibitors	16
Circ_0001667 knockdown blocks cancer progression and attenuates adriamycin resistance by depleting NCOA3 via releasing miR‐4458 in breast cancer	16
Fenofibrate attenuates ischemia reperfusion‐induced acute kidney injury and associated liver dysfunction in rats	16
Recent advances in trophoblast cell‐surface antigen 2 targeted therapy for solid tumors	16
Contribution of N‐heterocycles towards anti‐tubercular drug discovery (2014–2019); predicted and reengineered molecular frameworks	16
Approaches to minimize the effects of P‐glycoprotein in drug transport: A review	15
Designing therapeutic strategies to combat severe acute respiratory syndrome coronavirus‐2 disease: COVID‐19	15
Curcumol improves cisplatin sensitivity of human gastric cancer cells through inhibiting PI3K/AKT pathway	15
New multitarget directed benzimidazole‐2‐thiol‐based heterocycles as prospective anti‐radical and anti‐Alzheimer's agents	15
Lithium as a candidate treatment for COVID‐19: Promises and pitfalls	15
Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management	15
HDAC6 inhibitor, ACY1215 suppress the proliferation and induce apoptosis of gallbladder cancer cells and increased the chemotherapy effect of gemcitabine and oxaliplatin	15
YTHDF2 interference suppresses the EMT of cervical cancer cells and enhances cisplatin chemosensitivity by regulating AXIN1	15
Secoisolariciresinol diglucoside induces pyroptosis by activating caspase‐1 to cleave GSDMD in colorectal cancer cells	15
Therapeutic delivery with V‐amylose	14
Recent strategies for the development of oral medicines for the treatment of visceral leishmaniasis	14
Association study between HTR2A rs6313 polymorphism and early response to risperidone and olanzapine in schizophrenia patients	14
Synthesis, characterization, and anti‐cancer activity of new chalcone derivatives containing naphthalene and fluorine moieties	14
Synthesis of benzimidazole based hydrazones as non‐sugar based α‐glucosidase inhibitors: Structure activity relation and molecular docking	14
Neratinib inhibits proliferation and promotes apoptosis of acute myeloid leukemia cells by activating autophagy‐dependent ferroptosis	14
Effects of sinomenine on the proliferation, cytokine production, and regulatory T‐cell frequency in peripheral blood mononuclear cells of rheumatoid arthritis patients	14
Crocetin and related oxygen diffusion‐enhancing compounds: Review of chemical synthesis, pharmacology, clinical development, and novel therapeutic applications	14
CircMYBL2 regulates the resistance of cervical cancer cells to paclitaxel via miR‐665‐dependent regulation of EGFR	14
Monensin inhibits proliferation, migration, and promotes apoptosis of breast cancer cells via downregulating UBA2	13
Repurposing of FDA‐approved drugs as inhibitors of sterol C‐24 methyltransferase of Leishmania donovani to fight against leishmaniasis	13
Papaverine, a promising therapeutic agent for the treatment of COVID‐19 patients with underlying cardiovascular diseases (CVDs)	13
Anatomical distribution and expression of CYP in humans: Neuropharmacological implications	12
New isolate from Salvinia molesta with antioxidant and urease inhibitory activity	12
Conventional and microwave‐assisted organic synthesis of novel antimycobacterial agents bearing furan and pyridine hybrids	12
Volatile molecules for COVID‐19: A possible pharmacological strategy?	12
Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development	12
Step toward repurposing drug discovery for COVID‐19 therapeutics through in silico approach	11
The recent development of thymol derivative as a promising pharmacological scaffold	11
Races of small molecule clinical trials for the treatment of COVID‐19: An up‐to‐date comprehensive review	11
Repurposing current therapeutics for treating COVID‐19: A vital role of prescription records data mining	11
Discovery of novel indole‐1,2,4‐triazole derivatives as tubulin polymerization inhibitors	11

Exosome‐mediated PROTACs delivery to target viral infections	11
“Azole” as privileged heterocycle for targeting the inducible cyclooxygenase enzyme	11
An outlook on procedures of conjugating folate to (co)polymers and drugs for effective cancer targeting	11
The mechanism of Arhalofenate in alleviating hyperuricemia―Activating PPARγ thereby reducing caspase‐1 activity	10
Oridonin alleviates d‐GalN/LPS‐induced acute liver injury by inhibiting NLRP3 inflammasome	10
Propofol promotes migration, alleviates inflammation, and apoptosis of lipopolysaccharide‐induced human pulmonary microvascular endothelial cells by activating PI3K/AKT signaling	10
Phosphate moiety in FDA‐approved pharmaceutical salts and prodrugs	10
Xanthatin inhibits human colon cancer cells progression via mTOR signaling mediated energy metabolism alteration	10
Discovery of substituted indole derivatives as allosteric inhibitors ofm6A‐RNAmethyltransferase,METTL3‐14 complex	10
PMEPA1 interference activates PTEN/PI3K/AKT, thereby inhibiting the proliferation, invasion and migration of pancreatic cancer cells and enhancing the sensi	10
TRPM2‐AS promotes paclitaxel resistance in prostate cancer by regulating FOXK1 via sponging miR‐497‐5p	10
Neobavaisoflavone protects osteoblasts from dexamethasone‐induced oxidative stress by upregulating the CRNDE‐mediated Nrf2/HO‐1 signaling pathway	10
MicroRNA‐214‐5p aggravates sepsis‐related acute kidney injury in mice	10
ORY‐1001, a KDM1A inhibitor, inhibits proliferation, and promotes apoptosis of triple negative breast cancer cells by inactivating androgen receptor	10
CircATL2 enhances paclitaxel resistance of ovarian cancer via impacting miR‐506‐3p/NFIB axis	10
Dendrobine modulates autophagy to alleviate ox‐LDL‐induced oxidative stress and senescence in HUVECs	10
Marein ameliorates Ang II/hypoxia‐induced abnormal glucolipid metabolism by modulating the HIF‐1α/PPARα/γ pathway in H9c2 cells	9
Emerging cases of mucormycosis under COVID‐19 pandemic in India: Misuse of antibiotics	9
CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR‐34a	9
Hirudin prevents vascular endothelial cell apoptosis and permeability enhancement induced by the serum from rat with chronic renal failure through inhibiting RhoA/ROCK signaling	9
Synthesis and characterization of new pyrazole–tetrazole derivatives as new vasorelaxant agents	9
CircFAT1 facilitates cervical cancer malignant progression by regulating ERK1/2 and p38 MAPK pathway through miR‐409‐3p/CDK8 axis	9
Antibacterial azole derivatives: Antibacterial activity, cytotoxicity, and in silico mechanistic studies	9
Repurposing of digoxin in pain and inflammation: An evidence‐based study	9
Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D‐mediated pyroptosis	9
Circ‐OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR‐558/THBS2 axis	9
Exploration of novel TOSMIC tethered imidazo[1,2‐a]pyridine compounds for the development of potential antifungal drug candidate	8
Dioscin induces osteosarcoma cell apoptosis by upregulating ROS‐mediated P38 MAPK signaling	8
Loganin exerts a protective effect on ischemia–reperfusion‐induced acute kidney injury by regulating JAK2/STAT3 and Nrf2/HO‐1 signaling pathways	8
Paeonol inhibits human lung cancer cell viability and metastasis in vitro via miR‐126‐5p/ZEB2 axis	8
Design, synthesis, molecular docking, anti‐quorum sensing, and anti‐biofilm activity of pyochelin‐zingerone conjugate	8
Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies	8
Design, synthesis, and structure–activity relationship of caffeine‐based triazoles as dual AChE and BACE‐1 inhibitors	8
Butyrate prevents the migration and invasion, and aerobic glycolysis in gastric cancer via inhibiting Wnt/β‐catenin/c‐Myc signaling	8
Comprehensive investigations for a potential natural prophylaxis—A cellular and murine model for apple cider vinegar against hydrogen peroxide and scopolamine induced oxidative stress	8
Potential of nafimidone derivatives against co‐morbidities of epilepsy: In vitro, in vivo, and in silico investigations	8
Road‐map of pre‐clinical treatment for Visceral Leishmaniasis	7
Amino acid conjugates of 2‐mercaptobenzimidazole provide better anti‐inflammatory pharmacology and improved toxicity profile	7
Progress of small molecules for targeted protein degradation: PROTACs and other technologies	7
Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors	7
Flufenamic acid alleviates sepsis‐induced lung injury by up‐regulating CBR1	7
Design, synthesis, and biological evaluation of thienopyrimidine derivatives as multifunctional agents against Alzheimer's disease	7
Alpha‐lipoic acid: A promising adjuvant for nonsteroidal anti‐inflammatory drugs therapy with improved efficacy and gastroprotection	7
Disruption of the biological activity of protease‐activated receptors2/4 in adults rather than children in SARS CoV‐2 virus‐mediated mortality in COVID‐19 infection	7
Artificial intelligence revolutionizing drug development: Exploring opportunities and challenges	7
Stevioside protects against rhabdomyolysis‐induced acute kidney injury through PPAR‐γ agonism in rats	7
Irigenin alleviates angiotensin II‐induced oxidative stress and apoptosis in HUVEC cells by activating Nrf2 pathway	7
Astragaloside IV enhances the sensibility of lung adenocarcinoma cells to bevacizumab by inhibiting autophagy	7
Palmatine attenuates hepatocyte injury by promoting autophagy via the AMPK/mTOR pathway after alcoholic liver disease	7
Tanshinol alleviates ulcerative colitis by promoting the expression of VLDLR	7
Antibacterial and anti‐inflammatory activity of valproic acid‐pyrazole conjugates as a potential agent against periodontitis	7
Sophoraflavanone G suppresses the progression of triple‐negative breast cancer via the inactivation of EGFR–PI3K–AKT signaling	7
Toosendanin inhibits colorectal cancer cell growth through the Hedgehog pathway by targeting Shh	7
Design, synthesis, and structure–activity relationship study of O‐prenylated 3‐acetylcoumarins as potent inhibitors of soybean 15‐lipoxygenase	7
Bacterial hepatocyte growth factor receptor agonist stimulates hepatocyte proliferation and accelerates liver regeneration in a partial hepatectomy rat model	7
Effects of notoginsenoside R1 on attenuating depressive behavior induced by chronic stress in rats through induction of PI3K/AKT/NF‐κB pathway	7
Versatile use of Carmofur: A comprehensive review of its chemistry and pharmacology	6
Design, synthesis, biological evaluation, and molecular docking of new benzofuran and indole derivatives as tubulin polymerization inhibitors	6
RNA editing enzyme adenosine deaminases acting on RNA 1 deficiency increases the sensitivity of non‐small cell lung cancer cells to anlotinib by regulating CX3CR1‐fractalkine exp	6
A novel salvianolic acid A analog with resveratrol structure and its antioxidant activities in vitro and in vivo	6
Quercetin regulates vascular endothelium function in chronic renal failure via modulation of Eph/Cav‐1 signaling	6
Beta‐lactam resistance and the effectiveness of antimicrobial peptides against KPC‐producing bacteria	6
New chromanone derivatives containing thiazoles: Synthesis and antitumor activity evaluation on A549 lung cancer cell line	6
Synthesis and evaluation of 2‐(4‐[4‐acetylpiperazine‐1‐carbonyl] phenyl)‐1H‐benzo[d]imidazole‐4‐carboxamide derivatives as potential PARP‐1 inhibitors and preliminary study on st	6
Aspartate semialdehyde dehydrogenase inhibition suppresses the growth of the pathogenic fungus Candida albicans	6
Solasonine alleviates high glucose‐induced podocyte injury through increasing Nrf2‐medicated inhibition of NLRP3 activation	6
Antiparasitic activities of novel pyrimidine N‐acylhydrazone hybrids	6
Celastrol: A lead compound that inhibits SARS‐CoV‐2 replication, the activity of viral and human cysteine proteases, and virus‐induced IL‐6 secretion	6
Design, synthesis and biological evaluation of several aromatic substituted chalcones as antimalarial agents	6
Sodium Danshensu inhibits the progression of lung cancer by regulating PI3K/Akt signaling pathway	6
Toad venom bufadienolides and bufotoxins: An updated review	6
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR‐144‐3p/IGF2R axis	6
PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA‐induced granulosa cell apoptosis in vitro	6
Benzoxazolone‐arylpiperazinyl scaffold‐based PET ligand for 5‐HT7: Synthesis and biological evaluation	6
Redox‐responsive glycosylated combretastatin A‐4 derivative as novel tubulin polymerization inhibitor for glioma and drug delivery	6
Apigenin inhibits isoproterenol‐induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR‐122‐5p/155‐5p expressions	6
A new series of thiazole‐hydrazone hybrids for Akt‐targeted therapy of non‐small cell lung cancer	6
A novel series of substituted 1,2,3‐triazoles as cancer stem cell inhibitors: Synthesis and biological evaluation	6
The National Institutes of Health Chemical Countermeasures Research Program (NIH CCRP): A collaborative opportunity to develop effective and accessible chemical medical countermeasures for	6
Naringin treatment improved main clozapine‐induced adverse effects in rats; emphasis on weight gain, metabolic abnormalities, and agranulocytosis	6

Probing 3CL protease: Rationally designed chemical moieties for COVID‐19	6
Synthesis and in vitro antileishmanial efficacy of benzyl analogues of nifuroxazide	6
Protection of clozapine‐induced oxidative stress and mitochondrial dysfunction by kaempferol in rat cardiomyocytes	6
9‐Ethynyl noscapine induces G2 /M arrest and apoptosis by disrupting tubulin polymerization in cervical cancer	6