OOIR: Observatory of International Research

Papers

(The TQCC of Drug Development Research is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Serum Amyloid A1 Mediates Paclitaxel Resistance via MD2‐Dependent Pathways in Triple‐Negative Breast Cancer	80
Linear Antimicrobial Peptide, Containing a Diindolyl Methane Unnatural Amino Acid, Potentiates Gentamicin Against Methicillin‐Resistant Staphylococcus aureus	66
Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases	59
Carboxymethyl Starch: A Contemporary Paradigm for Anti Cancer Drug Delivery	56
RETRACTION: “Dose‐dependent Chemopreventive Effects of Citronellol in DMBA‐Induced Breast Cancer Among Rats”	54
Safety study of topical naltrexone therapy for diabetic skin wounds is confirmed in Göttingen mini‐pigs	44
Thrombospondin‐1 mimic peptide PKHB1 induced endoplasmic reticulum stress‐mediated but CD47‐independent apoptosis in non‐small cell lung cancer	43
Antitumor activity of galaxamide involved in cell apoptosis and stemness by inhibiting Wnt/β‐catenin pathway in cervical cancer	39
Comprehensive characterization and preclinical assessment of an imidazopyridine‐based anticancer lead molecule	38
Pyridazine derivatives as selective COX‐2 inhibitors: A review on recent updates	38
Tirbanibulin (KX2‐391) analog KX2‐361 inhibits botulinum neurotoxin serotype A mediated SNAP‐25 cleavage in pre‐ and post‐intoxication models in cells	32
New insights into the anticancer therapeutic potential of icaritin and its synthetic derivatives	32
Novel matrinic acid derivatives bearing 2‐anilinothiazole structure for non‐small cell lung cancer treatment with improved Hsp90 targeting effect	27
Synthesis and investigation of the cholinesterase inhibitory and antioxidant capacities of some novel N'‐(quinolin‐4‐ylmethylene)propanehydrazides against Alzheimer's disease	26
New S‐substituted‐3‐phenyltetrahydrobenzo[4,5]thieno[2,3‐d]pyrimidin‐4(3H)‐one scaffold with promising anticancer activity profile through the regulation and inhibition of mutated	25
Quercetin ameliorates salivary gland apoptosis and inflammation in primary Sjögren's syndrome through regulation of the leptin/OB‐R signaling	25
Antiplasmodial action of 4‐nitrobenzenesulfonamide chalcones: Design, synthesis, characterisation, in vitro and in silico evaluation against blood stages of Plasmodium falciparum 3D7	25
Susceptibility of Leishmania to novel pentavalent organometallics: Investigating impact on DNA and membrane integrity in antimony(III)‐sensitive and ‐resistant strains	24
Design and synthesis of novel tetrabromophthalimide derivatives as potential tubulin inhibitors endowed with apoptotic induction for cancer treatment	23
Indole‐based aryl sulfides target the cell wall of Staphylococcus aureus without detectable resistance	22
Structural Diversity and Mutational Challenges of Toll‐Like Receptor 4 Antagonists as Inflammatory Pathway Blocker	21
Trifolirhizin targets PTK6 to induce autophagy and exerts antitumor effects in nasopharyngeal carcinoma	21
Anxiolytic Effect of Sesamol, Possibly Through the GABAkine Interaction Pathway	20
The Role of Fatty Acid Metabolism, the Related Potential Biomarkers, and Targeted Therapeutic Strategies in Gastrointestinal Cancers	20
Repurposing of digoxin in pain and inflammation: An evidence‐based study	19

Design, synthesis of novel chromene‐based scaffolds targeting hepatocellular carcinoma: Cell cycle arrest, cytotoxic effect against resistant cancer cells, apoptosis induction, and c‐Src inhibition	19
Neutrophil hitchhiking: Riding the drug delivery wave to treat diseases	19
A growth‐based assay using fluorescent protein emission to screen for S‐adenosylmethionine synthetase inhibitors	18
Design, synthesis, in vitro, and in vivo evaluation of novel phthalazinone‐based derivatives as promising acetylcholinesterase inhibitors for treatment of Alzheimer's disease	18
Early investigation of a novel SI306 theranostic prodrug for glioblastoma treatment	18
A liposomal radionanoformulation for targeted drug delivery and real time monitoring by radionuclide imaging for HER2 overexpressing cancers	17
The transcription factor ATF2 promotes gastric cancer progression by activating the METTL3/cyclin D1 pathway	17
Research Progress of Endoplasmic Reticulum Targeting Metal Complexes in Cancer Therapy	17
Cinepazide maleate promotes recovery from spinal cord injury by inhibiting inflammation and prolonging neuronal survival	17
Sulfamethizole Attenuates Pentylenetetrazole‐Induced Seizures in Mice via mTOR Inhibition	17
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Benzoxazolone‐arylpiperazinyl scaffold‐based PET ligand for 5‐HT₇: Synthesis and biological evaluation	16
Multitargeted C9‐substituted ester and ether derivatives of berberrubine for Alzheimer's disease: Design, synthesis, biological evaluation, metabolic stability, and pharmacokinetics	16
Issue Information	16
The HSP90 inhibitor 17‐AAG induced calcium‐mediated apoptosis in filarial parasites	16
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Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies	15
Terbutaline attenuates LPS ‐induced injury of pulmonary microvascular endothelial cells by cAMP /Epac signaling	15
CircRNF121 knockdown suppresses the progression of cervical cancer by regulating miR ‐153‐3p/ ATF2 axis and	15
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Naringenin inhibits autophagy and epithelial‐mesenchymal transition of human lens epithelial cells by regulating the Smad2/3 pathway	14
Potential of nafimidone derivatives against co‐morbidities of epilepsy: In vitro, in vivo, and in silico investigations	14
9‐Ethynyl noscapine induces G2 /M arrest and apoptosis by disrupting tubulin polymerization in cervical cancer	14
Redox‐responsive glycosylated combretastatin A‐4 derivative as novel tubulin polymerization inhibitor for glioma and drug delivery	14
Loganin exerts a protective effect on ischemia–reperfusion‐induced acute kidney injury by regulating JAK2/STAT3 and Nrf2/HO‐1 signaling pathways	14
Knockdown of IGF2BP3 inhibits the tumorigenesis of gallbladder cancer and modifies tumor microenvironment	13
Investigating the Impact of B Cell‐Related Genes on Colorectal Cancer Immunosuppressive Environment and Immunotherapy Evasion	13
Bioinformatics Exploration of the Therapeutic Potential of Lotus Seed Compounds in Multiple Sclerosis: A Network Analysis of c‐Jun Pathway	13
Imaging of bacterial infection: Harnessing positron emission tomography and Cherenkov luminescence imaging with UBI‐derived octapeptide	13
Reviewing on AI‐Designed Antibiotic Targeting Drug‐Resistant Superbugs by Emphasizing Mechanisms of Action	13
TSPAN1 silencing protects against cerulein‐induced pancreatic acinar cell injury via targeting AGR2	13
Issue Information	13
Astragaloside IV enhances the sensibility of lung adenocarcinoma cells to bevacizumab by inhibiting autophagy	13
Estradiol reduces ACE2 and TMPRSS2 mRNA levels in A549 human lung epithelial cells	13
Issue Information	12
Innovative Multitarget Organoselenium Hybrids With Apoptotic and Anti‐Inflammatory Properties Acting as JAK1/STAT3 Suppressors	12
Targeting TRAF3IP2 alleviates high glucose‐induced cardiomyocyte inflammation and apoptosis	12
Identification of potential targets against SARS‐CoV‐2 of antiviral drugs based on photoaffinity probes	12
Peimine‐induced apoptosis and inhibition of migration by regulating reactive oxygen species‐mediated MAPK/STAT3/NF‐κB and Wnt/β‐catenin signaling pathways in gastric cancer MKN‐45 cells	12
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Comparative pharmacodynamic and pharmacokinetic study of MIDD0301 and its (S) enantiomer	11
Circ_0001667 knockdown blocks cancer progression and attenuates adriamycin resistance by depleting NCOA3 via releasing miR‐4458 in breast cancer	11
Synthesis and evaluation of 2‐(4‐[4‐acetylpiperazine‐1‐carbonyl] phenyl)‐1H‐benzo[d]imidazole‐4‐carboxamide derivatives as potential PARP‐1 inhibitors and preliminary study on st	11
Pantoprazole suppresses carcinogenesis and growth of hepatocellular carcinoma by inhibiting glycolysis and Na⁺/H⁺ exchange	11
Parecoxib ameliorates renal toxicity and injury in sepsis‐induced mouse model and LPS ‐induced HK ‐2 cells	11
Downregulation of HIGD1B induces mitochondria‐mediated apoptosis in gastric cancer cells by inactivating Akt and ERK pathways	11
Novel Benzosuberone/Indanone‐Linked Thiazoles as Small‐Molecule SARS‐CoV‐2 Main Protease Inhibitors	11
Issue Information	11
2‐(Methyl(phenyl)amino)‐N‐(phenyloxyphenyl)acetamide structural motif representing a framework for selective SIRT2 inhibition	11
A thiourea‐bridged ^99mTc(CO)₃‐dipicolylamine‐2‐nitroimidazole complex for targeting tumor hypoxia: Utilizing metabolizable thiourea‐bridge to improve pharmacokinetics	11

Evaluation of geranylgeranyl diphosphate synthase inhibition as a novel strategy for the treatment of osteosarcoma and Ewing sarcoma	11
α‐Pinene inhibits the growth of cervical cancer cells through its proapoptotic activity by regulating the miR‐34a‐5p/Bcl‐2 signaling axis	10
Berberine attenuates inflammation and oxidative stress and modulates lymphocyte E‐NTPDase in acute hyperlipidemia	10
Explore new quinoxaline pharmacophore tethered sulfonamide fragments as in vitro α‐glucosidase, α‐amylase, and acetylcholinesterase inhibitors with ADMET and molecular modeling simulation	10
Therapeutic potential and research progress of diosgenin for lipid metabolism diseases	10
An appraisal of anticancer activity with structure–activity relationship of quinazoline and quinazolinone analogues through EGFR and VEGFR inhibition: A review	10
Tetrahydropalmatine induces the polarization of M1 macrophages to M2 to relieve limb ischemia‐reperfusion‐induced lung injury via inhibiting the TLR4/NF‐κB/NLRP3 signaling pathway	10
Schisandrin B ameliorates non‐alcoholic liver disease through anti‐inflammation activation in diabetic mice	9
Effects of toluidine blue O and methylene blue on growth and viability of pancreatic cancer cells	9
New chromanone derivatives containing thiazoles: Synthesis and antitumor activity evaluation on A549 lung cancer cell line	9
Issue Information	9
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Changes in the proportions of an active pharmaceutical through cocrystals	9
d‐Galactose treatment increasesACE2,TMPRSS2, andFURINand reducesSERPINA1mRNAexpression inA549human lung ep	9
Discovery of pyrazole‐1‐carboxamide derivatives as novel Gi‐biased μ‐opioid receptor agonists	9
Ginsenoside CK Promotes Cell Apoptosis via Regulating P53 Signal Pathway in Non‐Small Cell Lung Cancer	9
Lifitegrast, a Lymphocyte Function‐Associated Antigen‐1 Antagonist Demonstrates Beneficial Effect in Psoriasis	9
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Synthesis, characterization, molecular modeling studies, and biological evaluation of metal piroxicam complexes (M = Ni(II), Pt(IV), Pd(II), Ag(I)) as antibacterial and anticancer agents	9
Structure and activity of ananti‐epidermal growth factor receptor antibody without galactose‐α‐1,3‐galactose residues	9
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N‐Substituted piperazine‐coupled imidazo[2,1‐b]thiazoles as inhibitors of Mycobacterium tuberculosis: Synthesis, evaluation, and docking studies	9
Recent research brings hope for reshaping the co‐evolutionary arms race against parasitic infectious diseases	9
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A cytotoxic survey on 2‐amino‐1H‐imidazol based synthetic marine sponge alkaloid analogues	9
Fraxetin exerts anticancer effect in glioma by suppressing MiR‐21‐3p	8
Autophagic and apoptotic cell death induced by the quinoline derivative 2‐(6‐methoxynaphthalen‐2‐yl)quinolin‐4‐amine in pancreatic cancer cells is via ER stress and inhibition of Akt/m	8
Design, Synthesis and Molecular Docking of New Thieno[2,3‑d]Pyrimidin‐4‐One Derivatives as Dual EGFR and FGFR Inhibitors	8
Pyridazine and pyridazinone derivatives: Synthesis and in vitro investigation of their anti‐inflammatory potential in LPS‐induced RAW264.7 macrophages	8
Repurposing of FDA‐approved drugs as inhibitors of sterol C‐24 methyltransferase of Leishmania donovani to fight against leishmaniasis	8
Issue Information	8
Issue Information	8
Design and synthesis of vancomycin‐functionalized ZnFe₂O₄ nanoparticles as an effective antibacterial agent against methicillin‐resistant Staphylococcus aureus	8
Issue Information	8
Anlotinib improves bile duct ligature‐induced liver fibrosis in rats via antiangiogenesis regulated by VEGFR2/mTOR pathway	8
RecQ protein‐like 4 drives cisplatin chemosensitivity of cervical cancer cells by modulating annexin A2	8
Issue Information	8
Mesenchymal stem cell‐derived rapid drug screening system for Alzheimer's disease for the identification of novel drugs	8
New isolate from Salvinia molesta with antioxidant and urease inhibitory activity	8
Medicinal chemistry of pyrophosphate mimics: A mini review	8
Cover Image, Volume 85, Issue 1	8
Induction of apoptosis by oridonin in nonfunctioning pituitary adenoma cells	8
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Cellular and molecular mechanisms involved in the analgesic effects of botulinum neurotoxin: A literature review	7
T‐17, a novel cyclin‐dependent kinases/histone deacetylases dual inhibitor, induces cancer cells death through cell cycle arrest and apoptosis	7
Fasudil attenuates syncytin‐1‐mediated activation of microglia and impairments of motor neurons and motor function in mice	7
A novel cinnamic and caffeic acid‐conjugated peptide analogs with anticonvulsant and analgesic potency: Comparative analyses of trans/cis isomers	7
The role and advance of ubiquitination and deubiquitination in depression pathogenesis and treatment	7
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR‐144‐3p/IGF2R axis	7
Higher ATM expression in lymphoblastoid cell lines from centenarian compared with younger women	7
Biphenylsulfonamides as effective MMP‐2 inhibitors with promising antileukemic efficacy: Synthesis, in vitro biological evaluation, molecular docking, and MD simulation analysis	7
Discovery of 4‐(4‐aminophenyl)‐6‐phenylisoxazolo[3,4‐b]pyridine‐3‐amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia	7
Design, synthesis, in silico, and in vitro evaluation of novel benzyloxybenzene substituted (S)‐α‐amino amide derivatives as cholinesterases and monoaminoxidases inhibitor	7
Papaverine, a promising therapeutic agent for the treatment of COVID‐19 patients with underlying cardiovascular diseases (CVDs)	7
The cytotoxicity of karanjin toward breast cancer cells is involved in the PI3K/Akt signaling pathway	7
Knockdown of replication protein A 3 induces protective autophagy and enhances cisplatin sensitivity in lung adenocarcinoma by inhibiting AKT/mTOR signaling via binding to cyclin‐dependent kinases reg	7
AS602801 treatment suppresses breast cancer metastasis to the brain by interfering with gap‐junction communication by regulating Cx43 expression	7
Network pharmacology analysis and experimental verification of the antitumor effect and molecular mechanism of isocryptomerin on HepG2 cells	6
Identification of ROS and KEAP1‐related genes and verified targets of α‐hederin induce cell death for CRC	6
A novel thieno[2,3‐d]pyrimidine derivative inhibiting vascular endothelial growth factor receptor‐2: A story of computer‐aided drug discovery	6
Circ‐OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR‐558/THBS2 axis	6
Synthesis of tricyclic and tetracyclic benzo[6,7]cycloheptane derivatives linked morpholine moiety as CDK2 inhibitors	6
PX‐12 synergistically enhances the therapeutic efficacy of vorinostat under hypoxic tumor microenvironment in oral squamous cell carcinoma in vitro	6
Design of novel broad‐spectrum antiviral nucleoside analogues using natural bases ring‐opening strategy	6
Ricolinostat suppresses proliferation, promotes apoptosis, and enhances the antiproliferative activity of topoisomerase inhibitors in cervical cancer cells	6
MLLT3 knockdown suppresses proliferation and cell mobility in human lung adenocarcinoma	6
Diphenyl urea‐benzylidene acetohydrazide hybrids as fibroblast growth factor receptor 1 inhibitors and anticancer agents	6
Xanthatin induce DDP‐resistance lung cancer cells apoptosis through regulation of GLUT1 mediated ROS accumulation	6
AEBP1 Silencing Protects Against Cerebral Ischemia/Reperfusion Injury by Regulating Neuron Ferroptosis and Microglia M2 Polarization Through PRKCA‐PI3K‐Akt Axis	6
Asiaticoside enhances the effect of propofol on the invasion, ferroptosis and immune escape of bladder cancer	6
New Dichalcogenides Induce Oxidative Stress and Cell Death of Leishmania amazonensis	6
Design, synthesis, and bioactivity evaluation of clindamycin derivatives against multidrug‐resistant bacterial strains	6
Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line	6