Regulatory Toxicology and Pharmacology

Papers
(The H4-Index of Regulatory Toxicology and Pharmacology is 29. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)
ArticleCitations
Target organ toxicity in Sprague Dawley rats following oral exposure to complex groundwater mixture: Assessment of dose-response relationships using histopathological and biochemical alterations113
Two-year carcinogenicity study of a novel plasticizer, bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate (Eco-DEHCH), by oral diet in Han Wistar rats78
A review of common approaches to determining allocation factors and relative source contribution factors for drinking water contaminants: caveats and areas for improvement78
Ability of mathematical models to predict human in vivo percutaneous penetration of steroids77
Assessing biological oxidative damage induced by graphene-based materials: An asset for grouping approaches using the FRAS assay70
HESI GTTC ring trial: Concordance between Ames and rodent carcinogenicity outcomes for N-nitrosamines (NAs) with rat and hamster metabolic conditions69
Prevalence and sample sizes in pre-clinical studies64
Selectively addressing total risk avoidance for certain chemicals while overlooking others: The case of per-and-poly-fluoroalkyls62
Perspectives on the elimination of animal assays in the assessment of carcinogenicity60
Preclinical safety evaluation of the ethanolic extract from the aerial parts of Gomphrena celosioides Mart. in rodents55
Controlling cleaning agent residues in pharmaceutical manufacturing: A harmonized scientific strategy53
Safety evaluation of ondansetron after gestational exposure on male reproductive parameters in rats51
Is periventricular heterotopia a useful endpoint for developmental thyroid hormone system disruption in mouse toxicity studies?48
Acceptable intakes (AIs) for 11 small molecule N-nitrosamines (NAs)47
Control of N-nitrosamine impurities in drug products: Progressing the current CPCA framework and supporting the derivation of robust compound specific acceptable intakes44
Ames mutagenicity of 15 aryl, benzyl, and aliphatic ring N-nitrosamines43
A Cautionary tale for using read-across for cancer hazard classification: Case study of isoeugenol and methyl eugenol40
Importance of tailored non-clinical safety testing of novel antimalarial drugs: Industry best-practice37
Toltrazuril sulfone (Ponazuril) residue depletion in pig tissues and estimated withdrawal intervals36
Decision making in next generation risk assessment for skin allergy: Using historical clinical experience to benchmark risk36
Apparent Khat chewers exposure to DDT in Ethiopia and its potential toxic effects: A scoping review35
Editorial Board34
Exploring the potential of ToxCast™ data for mechanism-based prioritization of chemicals in regulatory context: Case study with priority existing chemicals (PECs) under K-REACH33
Acute dose toxicity evaluation of the food supplement calcium 3-hydroxy-3-methylbutyrate (HMB) in female Sprague Dawley rats33
Editorial Board31
Results from two-year rodent oral carcinogenicity studies of cizolirtine, a substance-P and calcitonin gene-related peptide release modulator31
Scientific considerations in the regulatory approval of generic (or biosimilar) version of enoxaparin sodium – A lifesaving carbohydrate polymer31
False positive findings associated with adenoviral vector-based vaccine underscore the regulatory necessity to eliminate abnormal toxicity test30
Nonclinical safety assessment of engineered T cell therapies30
The Dilemma of perfluorooctanoate (PFOA) human half-life29
Safety data sheets as an information pathway on hazards of occupationally used cleaning agents29
The SCCS Notes of Guidance for the testing of cosmetic ingredients and their safety evaluation, 11th revision, 30–31 March 2021, SCCS/1628/2129
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