OOIR: Observatory of International Research

Papers

(The H4-Index of Regulatory Toxicology and Pharmacology is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Target organ toxicity in Sprague Dawley rats following oral exposure to complex groundwater mixture: Assessment of dose-response relationships using histopathological and biochemical alterations	122
A review of common approaches to determining allocation factors and relative source contribution factors for drinking water contaminants: caveats and areas for improvement	83
Two-year carcinogenicity study of a novel plasticizer, bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate (Eco-DEHCH), by oral diet in Han Wistar rats	81
Selectively addressing total risk avoidance for certain chemicals while overlooking others: The case of per-and-poly-fluoroalkyls	75
Prevalence and sample sizes in pre-clinical studies	75
Preclinical safety evaluation of the ethanolic extract from the aerial parts of Gomphrena celosioides Mart. in rodents	68
Controlling cleaning agent residues in pharmaceutical manufacturing: A harmonized scientific strategy	67
Safety evaluation of ondansetron after gestational exposure on male reproductive parameters in rats	57
Is periventricular heterotopia a useful endpoint for developmental thyroid hormone system disruption in mouse toxicity studies?	57
Ames mutagenicity of 15 aryl, benzyl, and aliphatic ring N-nitrosamines	52
Risk Assessment and Pharmacokinetic Modeling of Incidental Ingestion of Ethanol from Mouthwash	51
Acceptable intakes (AIs) for 11 small molecule N-nitrosamines (NAs)	49
A Cautionary tale for using read-across for cancer hazard classification: Case study of isoeugenol and methyl eugenol	47
Control of N-nitrosamine impurities in drug products: Progressing the current CPCA framework and supporting the derivation of robust compound specific acceptable intakes	42
HESI GTTC ring trial: Concordance between Ames and rodent carcinogenicity outcomes for N-nitrosamines (NAs) with rat and hamster metabolic conditions	41
Incorporating Singaporean habits and practices for cosmetics and personal care products into a global consumer aggregate exposure model	39
Decision making in next generation risk assessment for skin allergy: Using historical clinical experience to benchmark risk	38
Acute dose toxicity evaluation of the food supplement calcium 3-hydroxy-3-methylbutyrate (HMB) in female Sprague Dawley rats	37
Importance of tailored non-clinical safety testing of novel antimalarial drugs: Industry best-practice	36
Toltrazuril sulfone (Ponazuril) residue depletion in pig tissues and estimated withdrawal intervals	35
Apparent Khat chewers exposure to DDT in Ethiopia and its potential toxic effects: A scoping review	34
Editorial: 2024 - A promising start for regulatory toxicology and pharmacology	34
Editorial Board	33
Results from two-year rodent oral carcinogenicity studies of cizolirtine, a substance-P and calcitonin gene-related peptide release modulator	32
False positive findings associated with adenoviral vector-based vaccine underscore the regulatory necessity to eliminate abnormal toxicity test	32

Scientific considerations in the regulatory approval of generic (or biosimilar) version of enoxaparin sodium – A lifesaving carbohydrate polymer	32
Editorial Board	32
Exploring the potential of ToxCast™ data for mechanism-based prioritization of chemicals in regulatory context: Case study with priority existing chemicals (PECs) under K-REACH	30
Editorial Board	30
Expert panel evaluation of the tumor modes of action for 1,4-dioxane and their implications for human risk assessment	30