OOIR: Observatory of International Research

Papers

(The H4-Index of Regulatory Toxicology and Pharmacology is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
A review of common approaches to determining allocation factors and relative source contribution factors for drinking water contaminants: caveats and areas for improvement	108
Two-year carcinogenicity study of a novel plasticizer, bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate (Eco-DEHCH), by oral diet in Han Wistar rats	92
Prevalence and sample sizes in pre-clinical studies	91
Selectively addressing total risk avoidance for certain chemicals while overlooking others: The case of per-and-poly-fluoroalkyls	87
Controlling cleaning agent residues in pharmaceutical manufacturing: A harmonized scientific strategy	86
Safety evaluation of ondansetron after gestational exposure on male reproductive parameters in rats	69
Target organ toxicity in Sprague Dawley rats following oral exposure to complex groundwater mixture: Assessment of dose-response relationships using histopathological and biochemical alterations	66
Ames mutagenicity of 15 aryl, benzyl, and aliphatic ring N-nitrosamines	61
Risk assessment and pharmacokinetic modeling of incidental ingestion of ethanol from mouthwash	59
Preclinical safety evaluation of the ethanolic extract from the aerial parts of Gomphrena celosioides Mart. in rodents	51
A Cautionary tale for using read-across for cancer hazard classification: Case study of isoeugenol and methyl eugenol	47
Is periventricular heterotopia a useful endpoint for developmental thyroid hormone system disruption in mouse toxicity studies?	46
Acceptable intakes (AIs) for 11 small molecule N-nitrosamines (NAs)	43
Decision making in next generation risk assessment for skin allergy: Using historical clinical experience to benchmark risk	41
HESI GTTC ring trial: Concordance between Ames and rodent carcinogenicity outcomes for N-nitrosamines (NAs) with rat and hamster metabolic conditions	41
Control of N-nitrosamine impurities in drug products: Progressing the current CPCA framework and supporting the derivation of robust compound specific acceptable intakes	41
Nonclinical development of advanced therapies: Best practices for translational and regulatory success	39
Editorial Board	38
Updated interim reference levels for dietary lead to support FDA's Closer to Zero action plan	37
Exploring the potential of ToxCast™ data for mechanism-based prioritization of chemicals in regulatory context: Case study with priority existing chemicals (PECs) under K-REACH	37
Toltrazuril sulfone (Ponazuril) residue depletion in pig tissues and estimated withdrawal intervals	36
Editorial: 2024 - A promising start for regulatory toxicology and pharmacology	35
Safety data sheets as an information pathway on hazards of occupationally used cleaning agents	35
Apparent Khat chewers exposure to DDT in Ethiopia and its potential toxic effects: A scoping review	34
Scientific considerations in the regulatory approval of generic (or biosimilar) version of enoxaparin sodium – A lifesaving carbohydrate polymer	34

Editorial Board	34
False positive findings associated with adenoviral vector-based vaccine underscore the regulatory necessity to eliminate abnormal toxicity test	31
Results from two-year rodent oral carcinogenicity studies of cizolirtine, a substance-P and calcitonin gene-related peptide release modulator	31
A tool to support food substance safety evaluations in the United States	30
Importance of tailored non-clinical safety testing of novel antimalarial drugs: Industry best-practice	30