Biochemical Society Transactions

Article	Citations
CD95/Fas ligand induced toxicity	107
Protein–protein and protein–lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation	93
Translation stalling in neurons: a critical mechanism for timely protein delivery to distal cellular processes	87
Stop CRYing! Inhibition of cryptochrome function by small proteins	77
Canonical and alternate mechanisms that regulate ubiquitylation by the E3 ligase parkin	77
The pleiotropic roles of eIF5A in cellular life and its therapeutic potential in cancer	75
Understanding immune signaling using advanced imaging techniques	58
Negative regulation of biofilm formation by nitric oxide sensing proteins	53
Regulation of germline proteostasis by HSF1 and insulin/IGF-1 signaling	49
Illuminating membrane structural dynamics of fusion and endocytosis with advanced light imaging techniques	49
Reconstituting membrane fission using a high content and throughput assay	49
Functions and mechanisms of eukaryotic RNA-guided programmed DNA elimination	49
Do tunneling nanotubes drive chemoresistance in solid tumors and other malignancies?	48
Inflammatory cell death: how macrophages sense neighbouring cell infection and damage	47
Structural insights into ferroportin mediated iron transport	41
Advances in understanding telomerase assembly	39
Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation	38
Connecting tubules: mechanisms of endoplasmic reticulum membrane fusion	38
Mechanisms underpinning natural variation in non-photochemical quenching kinetics	36
A guide into the world of high-resolution 3D imaging: the case of soft X-ray tomography for the life sciences	36
Exploring the multifunctionality of SR proteins	35
Caveolae and the oxidative stress response	34
Neurodevelopmental functions of CHD8: new insights and questions	34
Transgenic mouse models to study the physiological and pathophysiological roles of human Siglecs	33
The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI	33

Chemical catalysis by biological amyloids	33
LARP6 proteins in plants	33
Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance	33
Experimental systems for the analysis of mutational signatures: no ‘one-size-fits-all' solution	33
The impact of amino acid metabolism on adult neurogenesis	33
Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding?	32
The role of RHIM in necroptosis	32
Role of Yme1 in mitochondrial protein homeostasis: from regulation of protein import, OXPHOS function to lipid synthesis and mitochondrial dynamics	32
Structural switching of tubulin in the microtubule lattice	32
Aminoacyl-tRNA synthetase interactions in SARS-CoV-2 infection	31
Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions	30
Compatibility of termination mechanisms in bacterial transcription with inference on eukaryotic models	30
A dynamic role for transcription factors in restoring transcription through mitosis	30
Writing and erasing O-GlcNAc from target proteins in cells	30
The role of lipid scramblases in regulating lipid distributions at cellular membranes	30
Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity	29
The role of autophagy-lysosomal pathway in motor neuron diseases	29
The molecular mechanisms of diapause and diapause-like reversible arrest	29
Applications of Cryo-EM in small molecule and biologics drug design	29
Exploring potential developmental origins of common neurodegenerative disorders	29
Spo11: from topoisomerase VI to meiotic recombination initiator	29
Deconstructing cancer with precision genome editing	28
Maximizing the performance of protein-based fluorescent biosensors	28
The role of protein acetylation in regulating mitochondrial fusion and fission	27
Big data and artificial intelligence (AI) methodologies for computer-aided drug design (CADD)	27
Alpha-to-beta cell trans-differentiation for treatment of diabetes	27
S-acylation in apoptotic and non-apoptotic cell death: a central regulator of membrane dynamics and protein function	26
Transition from totipotency to pluripotency in mice: insights into molecular mechanisms	26
Correction: Current Working Models of SMC-driven DNA-loop extrusion	26
Encyclopaedia of eukaryotic DNA methylation: from patterns to mechanisms and functions	25
Last but not least: BFL-1 as an emerging target for anti-cancer therapies	25
Proteolytic regulation of mitochondrial oxidative phosphorylation components in plants	25
The SMN-ribosome interplay: a new opportunity for Spinal Muscular Atrophy therapies	24
Structural glycobiology – from enzymes to organelles	24
Functional characterisation of substrate-binding proteins to address nutrient uptake in marine picocyanobacteria	23
New insights into the structure and dynamics of the TOM complex in mitochondria	23
The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder	23
Periodic pattern formation during embryonic development	23
Conquer by cryo-EM without physically dividing	23
The long and the short of Periscope Proteins	23
Ribosomal RNA expansion segments and their role in ribosome biology	23
The evolution and structure/function of bHLH–PAS transcription factor family	22
Cryo-electron tomography: en route to the molecular anatomy of organisms and tissues	22
Extracellular membrane particles en route to the nucleus – exploring the VOR complex	22
Recent insights into the control of mitochondrial fission	22
CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact	22
The role of glycosaminoglycan modification in Hedgehog regulated tissue morphogenesis	22
Studying membrane proteins with MicroED	22
Ceramide microdomains: the major influencers of the sphingolipid media platform	22
Frankenstein Cas9: engineering improved gene editing systems	22

MsbA: an ABC transporter paradigm	21
GCN2: roles in tumour development and progression	21
The role of peroxidasin in solid cancer progression	21
Three-dimensional models of the lung: past, present and future: a mini review	21
Bile acid metabolism and FXR-mediated effects in human cholestatic liver disorders	21
Exploring cryo-electron microscopy with molecular dynamics	21
The octadecanoids: an emerging class of lipid mediators	21
Tetraspanins affect membrane structures and the trafficking of molecular partners: what impact on extracellular vesicles?	20
Molecular regulation of autophagosome formation	20
Chemical biology approaches to study histone interactors	20
Expect the unexpected: conventional and unconventional roles for cadherins in collective cell migration	20
Small regulatory RNAs in rice epigenetic regulation	20
Is the SPLUNC1-Orai1 axis a critical determinant of lung health?	19
Covalent activity-based probes for imaging of serine proteases	19
Voltage-clamp fluorometry for advancing mechanistic understanding of ion channel mechanisms with a focus on acid-sensing ion channels	19
Uncovering novel regulators of memory using C. elegans genetic and genomic analysis	19
Correction: Fast-forward on P-type ATPases: recent advances on structure and function	19
Sculpting with stiffness: rigidity as a regulator of morphogenesis	19
PIDD1 in cell cycle control, sterile inflammation and cell death	19
Structural basis of molecular recognition among classical cadherins mediating cell adhesion	19
Straight A’s: protein S-acylation in the activation and autophagic degradation of NOD-like receptors	18
Role of SWI/SNF chromatin remodeling genes in lung cancer development	18
Mre11–Rad50: the DNA end game	18
The mechanisms of class 1A PI3K and Wnt/β-catenin coupled signaling in breast cancer	18
IMPDH dysregulation in disease: a mini review	17
Biochemical approaches to assess the impact of post-translational modifications on pathogenic tau conformations using recombinant protein	17
Novel roles for G protein-coupled receptor kinases in cardiac injury and repair	17
Inferiority complex: why do sensory ion channels multimerize?	17
How lipids affect the energetics of co-translational alpha helical membrane protein folding	17
Research progress of ZIC5 for tumor metastasis	17
DDX41: exploring the roles of a versatile helicase	17
General strategies for using amino acid sequence data to guide biochemical investigation of protein function	17
The role of caspases as executioners of apoptosis	17
AAA+ proteins: one motor, multiple ways to work	17
The mechanisms of alkali therapy in targeting renal diseases	17
Improving photosynthesis through the enhancement of Rubisco carboxylation capacity	17
Understanding the role of ten-eleven translocation family proteins in kidney diseases	16
Structural insights into the membrane-bound proteolytic machinery of bacterial protein quality control	16
Transcriptional control of neural stem cell activity	16
Plant supercomplex I + III2 structure and function: implications for the growing field	16
S-acylation of Ca2+ transport proteins: molecular basis and functional consequences	16
The central role of translation elongation in response to stress	16
Correction: Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity	16
Non-canonical roles of ATG8 for TFEB activation	16
How does the tubulin code facilitate directed cell migration?	16
Folding speeds of helical membrane proteins	16
Organismal and cellular interactions in vertebrate–alga symbioses	16
Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery	16
Transcriptional bursting: from fundamentals to novel insights	16
Chlamydia trachomatis invasion: a duet of effectors	16
Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury	15
Structural and functional approaches to studying cAMP regulation of HCN channels	15
Unusual modes of cell and nuclear divisions characterise Drosophila development	15
Artificial protein assemblies with well-defined supramolecular protein nanostructures	15
Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation	15
Inorganic polyphosphate: from basic research to diagnostic and therapeutic opportunities in ALS/FTD	15
The role of post-translational modifications in synaptic AMPA receptor activity	15
The application of single-molecule optical tweezers to study disease-related structural dynamics in RNA	15
Exploring the structural dynamics of the vesicle priming machinery	15
Shaping epithelial lumina under pressure	15
The influence of high-order chromatin state in the regulation of stem cell fate	15
Gone with the Wnt(less): a mechanistic perspective on the journey of Wnt	15
Genome organization across scales: mechanistic insights from in vitro reconstitution studies	15
Age-dependent regenerative mechanisms in the brain	14
Suppression of double-stranded RNA sensing in cancer: molecular mechanisms and therapeutic potential	14
The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infections	14
Regulation of the generation of reactive oxygen species during photosynthetic electron transport	14
Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy	14
Molecular and structural perspectives on protein trafficking to the primary cilium membrane	14
Control of epithelial homeostasis by apical polarity: it takes a network	14
An update on the role of sex hormones in the function of the cardiorenal mitochondria	14
Organ-on-a-chip: current gaps and future directions	14
How do spherical bacteria regulate cell division?	14
Revealing chromatin-specific functions of histone deacylases	14
Understanding pyrethrin biosynthesis: toward and beyond natural pesticide overproduction	14
Cell-free genomics: transcription factor interactions in reconstituted naïve embryonic chromatin	14
Advances in understanding the mechanisms of the human papillomavirus oncoproteins	14
Computational approaches to understand transcription regulation in development	13
Intersectin — many facets of a scaffold protein	13
Studying histone inheritance in different systems using imaging-based methods and perspectives	13

Timely symbiosis: circadian control of legume-rhizobia symbiosis	13
Nano-organization of synaptic calcium signaling	13
Satellite cell dynamics during skeletal muscle hypertrophy	13
Lessons from natural molecular glue degraders	13
The interplay of helminthic neuropeptides and proteases in parasite survival and host immunomodulation	13
Advancing our knowledge of antigen processing with computational modelling, structural biology, and immunology	13
Npt2a as a target for treating hyperphosphatemia	13
How far can omics go in unveiling the mechanisms of floral senescence?	13
The emerging theme of 3′UTR mRNA isoform regulation in reprogramming of cell metabolism	13
The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation	12
GPX4: old lessons, new features	12
Specific isotopic labelling and reverse labelling for protein NMR spectroscopy: using metabolic precursors in sample preparation	12
Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens	12
The molecular mechanisms driving Plasmodium cell division	12
A closer look at the role of deubiquitinating enzymes in the Hypoxia Inducible Factor pathway	12
One genome, multiple phenotypes: decoding the evolution and mechanisms of environmentally induced developmental plasticity in insects	12
Human E3 ubiquitin ligases: accelerators and brakes for SARS-CoV-2 infection	12
Regulation of mTORC1 by the Rag GTPases	12
Mechanisms of epithelial growth and development in the zebrafish intestine	12
Nesprin-1: novel regulator of striated muscle nuclear positioning and mechanotransduction	12
Recent advances in understanding the role of extracellular vesicles from probiotics in intestinal immunity signaling	12
Bacterial microcompartments as a next-generation metabolic engineering tool: utilizing nature's solution for confining challenging catabolic pathways	12
Polycomb-mediated histone modifications and gene regulation	12
Targeting NRF2 to promote epithelial repair	12
Eliminating oncogenic RAS: back to the future at the drawing board	12
Should I stay or should I go: TFIIIC as assembly factor and barrier in RNA polymerase III transcription	12
Advances in utilizing reverse micelles to investigate membrane proteins	12
Striving for sustainable biosynthesis: discovery, diversification, and production of antimicrobial drugs in Escherichia coli	12
Redesigning miR-34a: structural and chemical advances in the therapeutic development of an miRNA anti-cancer agent	11
Enhancer target prediction: state-of-the-art approaches and future prospects	11
Unravelling mechanisms that govern meiotic crossover formation in wheat	11
Microbial pathways for advanced biofuel production	11
Proofreading mechanisms of the innate immune receptor RIG-I: distinguishing self and viral RNA	11
CRISPRi: a way to integrate iPSC-derived neuronal models	11
Mapping lipid pathways during phagocytosis	11
Effectors and effects of arginine methylation	11
Current understanding of heparanase 2 regulation, a non-heparanase	11
How do different cell populations orchestrate myelin regeneration?	11
To export, or not to export: how nuclear export factor variants resolve Piwi's dilemma	11
Effects of antibiotics on bacterial cell morphology and their physiological origins	11
Quaternary arrangements of membrane proteins: an aquaporin case	11
Current working models of SMC-driven DNA-loop extrusion	11
Developing high-affinity, oxygen-insensitive [NiFe]-hydrogenases as biocatalysts for energy conversion	11
Directed evolution approaches for optogenetic tool development	11
DIG-DUBs: mechanisms and functions of ISG15 deconjugation by human and viral cross-reactive ubiquitin proteases	11
Atomic force microscopy 3D structural reconstruction of individual particles in the study of amyloid protein assemblies	11
Correction: Exploring the influence of anionic lipids in the host cell membrane on viral fusion	11
Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins	11
The remodeling of Z-DNA in the mammalian germ line	11
The molecular mechanisms of human separase regulation	11
Endothelial Neuropilin-1: a multifaced signal transducer with an emerging role in inflammation and atherosclerosis beyond angiogenesis	11
Cofactor F420, an emerging redox power in biosynthesis of secondary metabolites	11
Whole-genome methods to define DNA and histone accessibility and long-range interactions in chromatin	10
Dopamine synthesis and transport: current and novel therapeutics for parkinsonisms	10
Exploring microRNAs in craniofacial regenerative medicine	10
Engineering CRISPR guide RNAs for programmable RNA sensors	10
Beyond expectations: the development and biological activity of cytokinin oxidase/dehydrogenase inhibitors	10
Decoding the sorghum methylome: understanding epigenetic contributions to agronomic traits	10
SUMO and the DNA damage response	10
Viral subversion of the cell polarity regulator Scribble	10
Engineering E. coli to synthesize butanol	10
Interactions between zinc and NRF2 in vascular redox signalling	10
The NMDAR-BK channelosomes as regulators of synaptic plasticity	10
Beyond the mono-nucleosome	10
The role of PQBP1 in neural development and function	10
Modification of extracellular matrix proteins by oxidants and electrophiles	10
Strength in numbers: effect of protein crowding on the shape of cell membranes	10
NLR immune receptors: structure and function in plant disease resistance	10
Scaffolds and the scaffolding domain: an alternative paradigm for caveolin-1 signaling	10
New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease	10
Epigenetic mechanisms in paediatric brain tumours: regulators lose control	10
A multi-dimensional view of context-dependent G protein-coupled receptor function	10
Deubiquitinases in muscle physiology and disorders	10
Live-cell visualization of cytochrome c: a tool to explore apoptosis	10
Differential functions of the KRAS splice variants	10
Regulation of cardiomyocyte intracellular trafficking and signal transduction by protein palmitoylation	10
The RNA cap methyltransferases RNMT and CMTR1 co-ordinate gene expression during neural differentiation	10
Role of macronutrient intake in the epigenetics of obesity	9
Technology to the rescue: how to uncover the role of transposable elements in preimplantation development	9
SMC-based immunity against extrachromosomal DNA elements	9
Structural insights into glucocorticoid receptor function	9
Controlled power: how biology manages succinate-driven energy release	9
ATP binding to Nerve Growth Factor (NGF) and pro-Nerve Growth Factor (proNGF): an endogenous molecular switch modulating neurotrophins activity	9
Computational methods to study enveloped viral entry	9
The cellular dynamics of neural tube formation	9
Computational exploration of cellular communication in skin from emerging single-cell and spatial transcriptomic data	9
Advances in nanobody multimerization and multispecificity: from in vivo assembly to in vitro production	9
What voltage-sensing phosphatases can reveal about the mechanisms of ion channel regulation by phosphoinositides	9
Is bRaQCing bad? New roles for ribosome associated quality control factors in stress granule regulation	9
The molecular mechanisms of the bacterial iron sensor IdeR	9
Mechanistic insights into protein folding by the eukaryotic chaperonin complex CCT	9
Single-molecule study of the dynamics of the molecular chaperone Hsp70 during the functional cycle	9
Post-translational regulation of the low-density lipoprotein receptor provides new targets for cholesterol regulation	9
Discovery of telomerase inhibitors: existing strategies and emerging innovations	9
Insights into mechanisms of ubiquitin ADP-ribosylation reversal	9