Biochemical Society Transactions

Article	Citations
Regulation of germline proteostasis by HSF1 and insulin/IGF-1 signaling	93
Transgenic mouse models to study the physiological and pathophysiological roles of human Siglecs	87
Structural insights into ferroportin mediated iron transport	87
CD95/Fas ligand induced toxicity	80
Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance	72
Inflammatory cell death: how macrophages sense neighbouring cell infection and damage	70
Exploring the multifunctionality of SR proteins	70
Caveolae and the oxidative stress response	66
Negative regulation of biofilm formation by nitric oxide sensing proteins	65
Illuminating membrane structural dynamics of fusion and endocytosis with advanced light imaging techniques	55
Reconstituting membrane fission using a high content and throughput assay	48
Organ-on-chip applications in drug discovery: an end user perspective	47
Chemical catalysis by biological amyloids	45
The impact of amino acid metabolism on adult neurogenesis	43
Advances in understanding telomerase assembly	41
Functions and mechanisms of eukaryotic RNA-guided programmed DNA elimination	41
A guide into the world of high-resolution 3D imaging: the case of soft X-ray tomography for the life sciences	40
Neurodevelopmental functions of CHD8: new insights and questions	39
Understanding immune signaling using advanced imaging techniques	36
Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation	35
Do tunneling nanotubes drive chemoresistance in solid tumors and other malignancies?	34
Stop CRYing! Inhibition of cryptochrome function by small proteins	34
The pleiotropic roles of eIF5A in cellular life and its therapeutic potential in cancer	33
Maximizing the performance of protein-based fluorescent biosensors	33
Protein–protein and protein–lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation	33

Connecting tubules: mechanisms of endoplasmic reticulum membrane fusion	33
Experimental systems for the analysis of mutational signatures: no ‘one-size-fits-all' solution	32
The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI	32
Aminoacyl-tRNA synthetase interactions in SARS-CoV-2 infection	32
Compatibility of termination mechanisms in bacterial transcription with inference on eukaryotic models	32
LARP6 proteins in plants	32
Writing and erasing O-GlcNAc from target proteins in cells	31
The role of autophagy-lysosomal pathway in motor neuron diseases	31
Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity	31
Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions	30
Deconstructing cancer with precision genome editing	30
Exploring potential developmental origins of common neurodegenerative disorders	29
Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding?	29
Spo11: from topoisomerase VI to meiotic recombination initiator	29
The role of lipid scramblases in regulating lipid distributions at cellular membranes	29
Role of Yme1 in mitochondrial protein homeostasis: from regulation of protein import, OXPHOS function to lipid synthesis and mitochondrial dynamics	29
The role of protein acetylation in regulating mitochondrial fusion and fission	29
Applications of Cryo-EM in small molecule and biologics drug design	28
The molecular mechanisms of diapause and diapause-like reversible arrest	28
Structural switching of tubulin in the microtubule lattice	28
Big data and artificial intelligence (AI) methodologies for computer-aided drug design (CADD)	28
Alpha-to-beta cell trans-differentiation for treatment of diabetes	28
A dynamic role for transcription factors in restoring transcription through mitosis	27
The role of RHIM in necroptosis	27
Correction: Current Working Models of SMC-driven DNA-loop extrusion	26
Conquer by cryo-EM without physically dividing	26
Microglia extracellular vesicles: focus on molecular composition and biological function	26
The SMN-ribosome interplay: a new opportunity for Spinal Muscular Atrophy therapies	26
New insights into the structure and dynamics of the TOM complex in mitochondria	26
Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease	26
Studying membrane proteins with MicroED	25
Transition from totipotency to pluripotency in mice: insights into molecular mechanisms	25
Functional characterisation of substrate-binding proteins to address nutrient uptake in marine picocyanobacteria	24
Last but not least: BFL-1 as an emerging target for anti-cancer therapies	24
The long and the short of Periscope Proteins	24
The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder	24
S-acylation in apoptotic and non-apoptotic cell death: a central regulator of membrane dynamics and protein function	24
Are cachexia-associated tumors transmitTERS of ER stress?	24
Proteolytic regulation of mitochondrial oxidative phosphorylation components in plants	23
Ribosomal RNA expansion segments and their role in ribosome biology	23
Efficiency and equity in origin licensing to ensure complete DNA replication	22
Ceramide microdomains: the major influencers of the sphingolipid media platform	22
Frankenstein Cas9: engineering improved gene editing systems	22
Encyclopaedia of eukaryotic DNA methylation: from patterns to mechanisms and functions	22
Structural glycobiology – from enzymes to organelles	22
Recent insights into the control of mitochondrial fission	22
Periodic pattern formation during embryonic development	22
The evolution and structure/function of bHLH–PAS transcription factor family	22
Three-dimensional models of the lung: past, present and future: a mini review	22
CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact	22

Cryo-electron tomography: en route to the molecular anatomy of organisms and tissues	21
GCN2: roles in tumour development and progression	21
The octadecanoids: an emerging class of lipid mediators	21
Small regulatory RNAs in rice epigenetic regulation	21
Expect the unexpected: conventional and unconventional roles for cadherins in collective cell migration	21
The role of peroxidasin in solid cancer progression	21
Tetraspanins affect membrane structures and the trafficking of molecular partners: what impact on extracellular vesicles?	21
The role of glycosaminoglycan modification in Hedgehog regulated tissue morphogenesis	20
Unravelling the structural complexity of protein–lipid interactions with neutron reflectometry	20
Extracellular membrane particles en route to the nucleus – exploring the VOR complex	20
Exploring cryo-electron microscopy with molecular dynamics	20
Molecular regulation of autophagosome formation	20
How neural stem cells contribute to neocortex development	20
Bile acid metabolism and FXR-mediated effects in human cholestatic liver disorders	20
Chemical biology approaches to study histone interactors	20
MsbA: an ABC transporter paradigm	20
Inferiority complex: why do sensory ion channels multimerize?	19
Uncovering novel regulators of memory using C. elegans genetic and genomic analysis	19
How lipids affect the energetics of co-translational alpha helical membrane protein folding	19
Voltage-clamp fluorometry for advancing mechanistic understanding of ion channel mechanisms with a focus on acid-sensing ion channels	19
Novel roles for G protein-coupled receptor kinases in cardiac injury and repair	18
PIDD1 in cell cycle control, sterile inflammation and cell death	18
DDX41: exploring the roles of a versatile helicase	18
Correction: Fast-forward on P-type ATPases: recent advances on structure and function	18
Role of SWI/SNF chromatin remodeling genes in lung cancer development	18
The central role of translation elongation in response to stress	18
Covalent activity-based probes for imaging of serine proteases	18
Structural basis of molecular recognition among classical cadherins mediating cell adhesion	18
Structural insights into the membrane-bound proteolytic machinery of bacterial protein quality control	18
IMPDH dysregulation in disease: a mini review	17
Research progress of ZIC5 for tumor metastasis	17
Organismal and cellular interactions in vertebrate–alga symbioses	17
Improving photosynthesis through the enhancement of Rubisco carboxylation capacity	17
The mechanisms of class 1A PI3K and Wnt/β-catenin coupled signaling in breast cancer	17
Sculpting with stiffness: rigidity as a regulator of morphogenesis	17
Biochemical approaches to assess the impact of post-translational modifications on pathogenic tau conformations using recombinant protein	17
AAA+ proteins: one motor, multiple ways to work	17
The role of caspases as executioners of apoptosis	17
The mechanisms of alkali therapy in targeting renal diseases	17
Ion channels as convergence points in the pathology of pulmonary arterial hypertension	17
Mre11–Rad50: the DNA end game	17
How does the tubulin code facilitate directed cell migration?	16
Transcriptional control of neural stem cell activity	16
Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases	16
Correction: Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity	16
Transcriptional bursting: from fundamentals to novel insights	16
General strategies for using amino acid sequence data to guide biochemical investigation of protein function	16
Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery	16
The influence of high-order chromatin state in the regulation of stem cell fate	16
Inorganic polyphosphate: from basic research to diagnostic and therapeutic opportunities in ALS/FTD	15
The role of pro-domains in human growth factors and cytokines	15
Plant supercomplex I + III2 structure and function: implications for the growing field	15
Structural and functional approaches to studying cAMP regulation of HCN channels	15
Folding speeds of helical membrane proteins	15
Understanding the role of ten-eleven translocation family proteins in kidney diseases	15
Artificial protein assemblies with well-defined supramolecular protein nanostructures	15
Exploring the structural dynamics of the vesicle priming machinery	15
Shaping epithelial lumina under pressure	15
Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury	15
Non-canonical roles of ATG8 for TFEB activation	15
Chlamydia trachomatis invasion: a duet of effectors	15
S-acylation of Ca2+ transport proteins: molecular basis and functional consequences	15
LRRK2 along the Golgi and lysosome connection: a jamming situation	14
Unusual modes of cell and nuclear divisions characterise Drosophila development	14
Solid state NMR of membrane proteins: methods and applications	14
The application of single-molecule optical tweezers to study disease-related structural dynamics in RNA	14
U7 deciphered: the mechanism that forms the unusual 3′ end of metazoan replication-dependent histone mRNAs	14
Gone with the Wnt(less): a mechanistic perspective on the journey of Wnt	14
Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation	14
How do spherical bacteria regulate cell division?	14
Suppression of double-stranded RNA sensing in cancer: molecular mechanisms and therapeutic potential	14
The role of post-translational modifications in synaptic AMPA receptor activity	14
Age-dependent regenerative mechanisms in the brain	14
The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infections	14
Molecular and structural perspectives on protein trafficking to the primary cilium membrane	14
Transcriptional control of ribosome biogenesis in yeast: links to growth and stress signals	13
Revealing chromatin-specific functions of histone deacylases	13
Human E3 ubiquitin ligases: accelerators and brakes for SARS-CoV-2 infection	13
Understanding pyrethrin biosynthesis: toward and beyond natural pesticide overproduction	13
Genome organization across scales: mechanistic insights from in vitro reconstitution studies	13

Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy	13
Advances in understanding the mechanisms of the human papillomavirus oncoproteins	13
An update on the role of sex hormones in the function of the cardiorenal mitochondria	13
Regulation of the generation of reactive oxygen species during photosynthetic electron transport	13
Organ-on-a-chip: current gaps and future directions	13
Cell-free genomics: transcription factor interactions in reconstituted naïve embryonic chromatin	13
Lessons from natural molecular glue degraders	13
Eliminating oncogenic RAS: back to the future at the drawing board	12
Nano-organization of synaptic calcium signaling	12
Targeting NRF2 to promote epithelial repair	12
Specific isotopic labelling and reverse labelling for protein NMR spectroscopy: using metabolic precursors in sample preparation	12
The interplay of helminthic neuropeptides and proteases in parasite survival and host immunomodulation	12
Satellite cell dynamics during skeletal muscle hypertrophy	12
Advancing our knowledge of antigen processing with computational modelling, structural biology, and immunology	12
Lipid–protein interactions in virus assembly and budding from the host cell plasma membrane	12
Computational approaches to understand transcription regulation in development	12
Regulation of mTORC1 by the Rag GTPases	12
How far can omics go in unveiling the mechanisms of floral senescence?	12
Bacterial microcompartments as a next-generation metabolic engineering tool: utilizing nature's solution for confining challenging catabolic pathways	12
Npt2a as a target for treating hyperphosphatemia	12
Timely symbiosis: circadian control of legume-rhizobia symbiosis	12
GPX4: old lessons, new features	12
Intersectin — many facets of a scaffold protein	12
One genome, multiple phenotypes: decoding the evolution and mechanisms of environmentally induced developmental plasticity in insects	12
Studying histone inheritance in different systems using imaging-based methods and perspectives	12
Polycomb-mediated histone modifications and gene regulation	12
Bioengineering silk into blood vessels	12
The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation	12
Current working models of SMC-driven DNA-loop extrusion	11
The molecular mechanisms driving Plasmodium cell division	11
The emerging theme of 3′UTR mRNA isoform regulation in reprogramming of cell metabolism	11
Microbial pathways for advanced biofuel production	11
Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens	11
Directed evolution approaches for optogenetic tool development	11
Modification of extracellular matrix proteins by oxidants and electrophiles	11
The remodeling of Z-DNA in the mammalian germ line	11
Recent advances in understanding the role of extracellular vesicles from probiotics in intestinal immunity signaling	11
Mechanisms of catalytic RNA molecules	11
Striving for sustainable biosynthesis: discovery, diversification, and production of antimicrobial drugs in Escherichia coli	11
Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers	11
Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins	11
Enhancer target prediction: state-of-the-art approaches and future prospects	11
Nesprin-1: novel regulator of striated muscle nuclear positioning and mechanotransduction	11
Effects of antibiotics on bacterial cell morphology and their physiological origins	11
Advances in utilizing reverse micelles to investigate membrane proteins	11
A closer look at the role of deubiquitinating enzymes in the Hypoxia Inducible Factor pathway	11
Mechanisms of epithelial growth and development in the zebrafish intestine	11
Unravelling mechanisms that govern meiotic crossover formation in wheat	11
The molecular mechanisms of human separase regulation	11
To export, or not to export: how nuclear export factor variants resolve Piwi's dilemma	11
Correction: Exploring the influence of anionic lipids in the host cell membrane on viral fusion	11
Cofactor F420, an emerging redox power in biosynthesis of secondary metabolites	11
Proofreading mechanisms of the innate immune receptor RIG-I: distinguishing self and viral RNA	10
Current understanding of heparanase 2 regulation, a non-heparanase	10
Viral subversion of the cell polarity regulator Scribble	10
CRISPRi: a way to integrate iPSC-derived neuronal models	10
Deubiquitinases in muscle physiology and disorders	10
Whole-genome methods to define DNA and histone accessibility and long-range interactions in chromatin	10
Regulation of cardiomyocyte intracellular trafficking and signal transduction by protein palmitoylation	10
Effectors and effects of arginine methylation	10
Endothelial Neuropilin-1: a multifaced signal transducer with an emerging role in inflammation and atherosclerosis beyond angiogenesis	10
Differential functions of the KRAS splice variants	10
Quaternary arrangements of membrane proteins: an aquaporin case	10
How do different cell populations orchestrate myelin regeneration?	10
Decoding the sorghum methylome: understanding epigenetic contributions to agronomic traits	10
Dopamine synthesis and transport: current and novel therapeutics for parkinsonisms	10
NLR immune receptors: structure and function in plant disease resistance	10
Atomic force microscopy 3D structural reconstruction of individual particles in the study of amyloid protein assemblies	10
Developing high-affinity, oxygen-insensitive [NiFe]-hydrogenases as biocatalysts for energy conversion	10
Mapping lipid pathways during phagocytosis	10
Strength in numbers: effect of protein crowding on the shape of cell membranes	10
SUMO and the DNA damage response	10
The RNA cap methyltransferases RNMT and CMTR1 co-ordinate gene expression during neural differentiation	10
Emerging roles of adhesion G protein-coupled receptors	10
Single-molecule study of the dynamics of the molecular chaperone Hsp70 during the functional cycle	9
Phase separation and viral factories: unveiling the physical processes supporting RNA packaging in dsRNA viruses	9
Engineering E. coli to synthesize butanol	9
Post-translational regulation of the low-density lipoprotein receptor provides new targets for cholesterol regulation	9
Scaffolds and the scaffolding domain: an alternative paradigm for caveolin-1 signaling	9
Interactions between zinc and NRF2 in vascular redox signalling	9
Computational methods to study enveloped viral entry	9
The role of PQBP1 in neural development and function	9
ESCRTing the RABs through conversion	9
The molecular mechanisms of the bacterial iron sensor IdeR	9
Exploring microRNAs in craniofacial regenerative medicine	9
Beyond expectations: the development and biological activity of cytokinin oxidase/dehydrogenase inhibitors	9
Advances in nanobody multimerization and multispecificity: from in vivo assembly to in vitro production	9
Integration of functional genomics data to uncover cell type-specific pathways affected in Parkinson's disease	9
The cellular dynamics of neural tube formation	9
Epigenetic mechanisms in paediatric brain tumours: regulators lose control	9
Beyond the mono-nucleosome	9
Technology to the rescue: how to uncover the role of transposable elements in preimplantation development	9
Engineering CRISPR guide RNAs for programmable RNA sensors	9
The NMDAR-BK channelosomes as regulators of synaptic plasticity	9
Role of macronutrient intake in the epigenetics of obesity	9