Biochemical Society Transactions

Article	Citations
Elevator-type mechanisms of membrane transport	79
Towards structure-focused glycoproteomics	60
Androgens and the masculinization programming window: human–rodent differences	58
Tying up loose ends: the N-degron and C-degron pathways of protein degradation	55
Trehalose 6-phosphate signalling and impact on crop yield	54
The pockets guide to HLA class I molecules	52
Structure determination of GPCRs: cryo-EM compared with X-ray crystallography	51
Functional heterogeneity in senescence	50
Molecular regulation of autophagosome formation	49
α-glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19	49
Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins	48
Unleashing the therapeutic potential of apoptotic bodies	46
Inhibition of RAF dimers: it takes two to tango	45
Regulation and functional role of the electron transport chain supercomplexes	44
Transcriptional control of ribosome biogenesis in yeast: links to growth and stress signals	44
Extracellular matrix stiffness and Wnt/β-catenin signaling in physiology and disease	42
Proteasome in action: substrate degradation by the 26S proteasome	42
Endothelial response to glucose: dysfunction, metabolism, and transport	41
Computational methods for exploring protein conformations	41
Bacteria autoaggregation: how and why bacteria stick together	41
Chain reactions: molecular mechanisms of RBR ubiquitin ligases	40
Hydrogen peroxide reactivity and specificity in thiol-based cell signalling	40
Alternative splicing in plant abiotic stress responses	40
Intrinsically disordered proteins and membranes: a marriage of convenience for cell signalling?	39
Transmission and prevention of SARS-CoV-2	38

Advances in the occurrence and biotherapy of osteoporosis	38
Mobility connects: transposable elements wire new transcriptional networks by transferring transcription factor binding motifs	37
Architectural RNA in chromatin organization	37
Lytic polysaccharide monooxygenases and other histidine-brace copper proteins: structure, oxygen activation and biotechnological applications	37
Class IA PI3K regulatory subunits: p110-independent roles and structures	34
Developments in tandem ion mobility mass spectrometry	34
Mammalian GPI-anchor modifications and the enzymes involved	33
Parkinson's disease and mitophagy: an emerging role for LRRK2	33
ERK1/2 in immune signalling	32
Gut microbiota and metabolites in the pathogenesis of endocrine disease	31
Aneuploidy in human eggs: contributions of the meiotic spindle	31
Promiscuity and specificity of eukaryotic glycosyltransferases	31
Molecular mechanisms mediating asymmetric subcellular localisation of the core planar polarity pathway proteins	31
Mechanisms of mitochondrial cell death	31
Big data and artificial intelligence (AI) methodologies for computer-aided drug design (CADD)	30
Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review	30
Nuclear import of histones	29
Structure and regulation of coronavirus genomes: state-of-the-art and novel insights from SARS-CoV-2 studies	29
Current problems and future avenues in proteoliposome research	29
CRISPR-based gene expression control for synthetic gene circuits	29
Decellularized bone extracellular matrix in skeletal tissue engineering	29
Synthetic biology approaches towards the recycling of metals from the environment	28
The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape	28
The ERK mitogen-activated protein kinase signaling network: the final frontier in RAS signal transduction	28
Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases	28
Nicotinamide adenine dinucleotide (NAD+): essential redox metabolite, co-substrate and an anti-cancer and anti-ageing therapeutic target	28
The effect of Irisin on bone cells in vivo and in vitro	28
Materno-fetal cholesterol transport during pregnancy	28
Does it take two to tango? RING domain self-association and activity in TRIM E3 ubiquitin ligases	28
New appreciation for an old pathway: the Lands Cycle moves into new arenas in health and disease	27
Leloir glycosyltransferases of natural product C-glycosylation: structure, mechanism and specificity	27
Inhibitors in AKTion: ATP-competitive vs allosteric	27
Advances in modelling the human microbiome–gut–brain axis in vitro	26
Improving photosynthesis through the enhancement of Rubisco carboxylation capacity	26
The needle and the haystack: single molecule tracking to probe the transcription factor search in eukaryotes	26
The Hitchhiker's guide to glycoproteomics	26
Systems approach to rational combination therapy: PARP inhibitors	25
Progress in the therapeutic inhibition of Cdc42 signalling	25
Activation of STAT transcription factors by the Rho-family GTPases	25
Sequence determinants, function, and evolution of CpG islands	25
Engineering with NanoLuc: a playground for the development of bioluminescent protein switches and sensors	25
Human 2-oxoglutarate-dependent oxygenases: nutrient sensors, stress responders, and disease mediators	24
Pore-forming toxins in infection and immunity	24
Antivirals that target the host IMPα/β1-virus interface	24
The development of proteinase-activated receptor-2 modulators and the challenges involved	24
Smc5/6, an atypical SMC complex with two RING-type subunits	23
The evolution of multicellularity and cancer: views and paradigms	23
The role of lactobacilli in inhibiting skin pathogens	23
The tryptophan biosynthetic pathway is essential forMycobacterium tuberculosisto cause disease	23
Targeting MmpL3 for anti-tuberculosis drug development	23

Phagocytic clearance of apoptotic, necrotic, necroptotic and pyroptotic cells	23
The mitochondrial ADP/ATP carrier exists and functions as a monomer	23
Role of the adaptive immune system in atherosclerosis	22
Transcriptome view of a killer: African swine fever virus	22
VDAC2 and the BCL-2 family of proteins	22
The role of caspases as executioners of apoptosis	22
The impact of photorespiration on plant primary metabolism through metabolic and redox regulation	22
Organ-on-chip applications in drug discovery: an end user perspective	22
Gene transcription and chromatin regulation in hypoxia	22
Emerging mass spectrometry-based proteomics methodologies for novel biomedical applications	22
How neural stem cells contribute to neocortex development	22
Therapeutic targeting of mitophagy in Parkinson's disease	21
Plant transporters involved in combating boron toxicity: beyond 3D structures	21
Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for…	21
The molecular basis of plant cellulose synthase complex organisation and assembly	21
Galectin-8, cytokines, and the storm	21
Function and regulation of corin in physiology and disease	20
The functional importance of VCP to maintaining cellular protein homeostasis	20
IMPDH dysregulation in disease: a mini review	20
Engineering pattern formation and morphogenesis	20
Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance	20
Latest update on chemokine receptors as therapeutic targets	19
Fuzzy protein theory for disordered proteins	19
GCN2: roles in tumour development and progression	19
Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease	19
Structural insights into glucocorticoid receptor function	19
Detergent-free systems for structural studies of membrane proteins	19
The emerging complexity of PDGFRs: activation, internalization and signal attenuation	19
Identifying key regulators of the intestinal stem cell niche	19
Recent developments in sustainably sourced protein-based biomaterials	19
Solar-driven water-splitting provides a solution to the energy problem underpinning climate change	18
How do histone modifications contribute to transgenerational epigenetic inheritance in C. elegans?	18
The evolutionary dynamics of venom toxins made by insects and other animals	18
Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity	18
Exploring the multifunctionality of SR proteins	18
From diagnosis to therapy in Duchenne muscular dystrophy	18
Not just a writer: PRC2 as a chromatin reader	18
Functional interrogation and therapeutic targeting of protein tyrosine phosphatases	17
Emerging roles of adhesion G protein-coupled receptors	17
The diverse arsenal of type III CRISPR–Cas-associated CARF and SAVED effectors	17
Extracellular vesicles and the extracellular matrix: a new paradigm or old news?	17
Type 2 immunity in intestinal homeostasis and inflammatory bowel disease	17
Role of macrophage extracellular traps in innate immunity and inflammatory disease	17
Serpins in cartilage and osteoarthritis: what do we know?	17
Combinatorial biosynthesis for the generation of new-to-nature peptide antimicrobials	17
Condensin complexes: understanding loop extrusion one conformational change at a time	17
Protein-fragment complementation assays for large-scale analysis of protein–protein interactions	17
Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms	17
What defines the maternal transcriptome?	17
Bile acid metabolism and FXR-mediated effects in human cholestatic liver disorders	17
Fluorescent proteins for in vivo imaging, where's the biliverdin?	17
GPX4: old lessons, new features	17
Molecular genetics of renal ciliopathies	16
Organ-on-a-chip: current gaps and future directions	16
Aberrant protein glycosylation in cancer: implications in targeted therapy	16
Unlocking immune-mediated disease mechanisms with transcriptomics	16
Relationship between mucosa-associated gut microbiota and human diseases	16
Molecular subversion of Cdc42 signalling in cancer	16
Varicella-zoster virus: molecular controls of cell fusion-dependent pathogenesis	16
The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccines	16
Host ADP-ribosylation and the SARS-CoV-2 macrodomain	16
Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking	16
Emerging aspects in the regulation of ferroptosis	15
The complex, bidirectional role of extracellular vesicles in infection	15
The role of the blood–brain barrier during neurological disease and infection	15
Biomolecular complex viewed by dynamic nuclear polarization solid-state NMR spectroscopy	15
RNA transfer through tunneling nanotubes	15
Structural dynamics of ABC transporters: molecular simulation studies	15
Caught in the act: structural dynamics of replication origin activation and fork progression	15
AAA+ proteins: one motor, multiple ways to work	15
Three-dimensional models of the lung: past, present and future: a mini review	15
The expanding world of metabolic enzymes moonlighting as RNA binding proteins	15
Applications of Cryo-EM in small molecule and biologics drug design	15
Methods for the solubilisation of membrane proteins: the micelle-aneous world of membrane protein solubilisation	15
The BAF chromatin remodeling complexes: structure, function, and synthetic lethalities	15
Full-length galectin-8 and separate carbohydrate recognition domains: the whole is greater than the sum of its parts?	15
HTR6 and SSTR3 targeting to primary cilia	15
Inhibition of RAS: proven and potential vulnerabilities	15
Controlling gene expression with light: a multidisciplinary endeavour	15
Circadian rhythm of lipid metabolism	15

Structure and evolution of the bifidobacterial carbohydrate metabolism proteins and enzymes	15
A review of methods for the reconstruction and analysis of integrated genome-scale models of metabolism and regulation	14
OFD Type I syndrome: lessons learned from a rare ciliopathy	14
TOP2B's contributions to transcription	14
Drug repurposing in silico screening platforms	14
Effects of carboxyl-terminal methylation on holoenzyme function of the PP2A subfamily	14
Biological insights from SMA-extracted proteins	14
Molecular and structural aspects of gasdermin family pores and insights into gasdermin-elicited programmed cell death	14
Monolysocardiolipin (MLCL) interactions with mitochondrial membrane proteins	14
How activated NLRs induce anti-microbial defenses in plants	14
ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control	14
Daylight-PDT: everything under the sun	14
The structural biology of canonical Wnt signalling	14
Epigenetic regulation of human non-coding RNA gene transcription	14
Targeting the DNA damage response for cancer therapy	14
Interferon-induced GTPases orchestrate host cell-autonomous defence against bacterial pathogens	14
HSP90 as a regulator of extracellular matrix dynamics	14
Promotion of cancer cell stemness by Ras	14
Translational control in cell ageing: an update	14
Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance	14
Rotor subunits adaptations in ATP synthases from photosynthetic organisms	14
CDKL5 deficiency disorder: molecular insights and mechanisms of pathogenicity to fast-track therapeutic development	14
An integrated view of innate immune mechanisms in C. elegans	14
DNA methylation: from model plants to vegetable crops	14
Lipid–protein interactions in virus assembly and budding from the host cell plasma membrane	13
Protein–protein and protein–lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation	13
New perspectives of the cardiac cellular landscape: mapping cellular mediators of cardiac fibrosis using single-cell transcriptomics	13
Biofilm and swarming emergent behaviours controlled through the aid of biophysical understanding and tools	13
ISG15 driven cellular responses to virus infection	13
Programmed DNA elimination: silencing genes and repetitive sequences in somatic cells	13
Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens	13
Using computational modelling to reveal mechanisms of epigenetic Polycomb control	13
Mechanistic insights into KDM4A driven genomic instability	13
Understanding the immune responses involved in mediating protection or immunopathology during leishmaniasis	13
Great balls of fire: activation and signalling of inflammatory caspases	13
Plant derived cyclic peptides	13
Microglia extracellular vesicles: focus on molecular composition and biological function	13
LRRK2 along the Golgi and lysosome connection: a jamming situation	13
CHCHD4 (MIA40) and the mitochondrial disulfide relay system	13
From protocells to prototissues: a materials chemistry approach	13
Nutrient regulation of the flow of genetic information by O-GlcNAcylation	13
Relating SMCHD1 structure to its function in epigenetic silencing	13
The molecular pathogenesis of repeat expansion diseases	13
PIDD1 in cell cycle control, sterile inflammation and cell death	12
Mechanisms of eukaryotic replisome disassembly	12
Cellular feedback dynamics and multilevel regulation driven by the hippo pathway	12
Single-molecule tracking (SMT): a window into live-cell transcription biochemistry	12
ER functions are exploited by viruses to support distinct stages of their life cycle	12
‘PIPs’ in DNA polymerase: PCNA interaction affairs	12
To be or not be (in the LAD): emerging roles of lamin proteins in transcriptional regulation	12
Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity	12
Towards the routine use of in silico screenings for drug discovery using metabolic modelling	12
The role of RHIM in necroptosis	12
Viscoelastic properties of epithelial cells	12
It's not just a phase; ubiquitination in cytosolic protein quality control	12
The surprising structural and mechanistic dichotomy of membrane-associated phosphoglycosyl transferases	12
Tall tails: cryo-electron microscopy of phage tail DNA ejection conduits	12
Driving antimalarial design through understanding of target mechanism	12
Evolution and diversification of the nuclear pore complex	12