Biochemical Society Transactions

Article	Citations
Regulation of germline proteostasis by HSF1 and insulin/IGF-1 signaling	88
Illuminating membrane structural dynamics of fusion and endocytosis with advanced light imaging techniques	84
Structural insights into ferroportin mediated iron transport	83
Transgenic mouse models to study the physiological and pathophysiological roles of human Siglecs	75
CD95/Fas ligand induced toxicity	70
Regulation of the antigen presentation machinery in cancer and its implication for immune surveillance	68
Negative regulation of biofilm formation by nitric oxide sensing proteins	68
Chemical catalysis by biological amyloids	65
Organ-on-chip applications in drug discovery: an end user perspective	65
The impact of amino acid metabolism on adult neurogenesis	62
Functions and mechanisms of eukaryotic RNA-guided programmed DNA elimination	52
Caveolae and the oxidative stress response	51
Advances in understanding telomerase assembly	46
A guide into the world of high-resolution 3D imaging: the case of soft X-ray tomography for the life sciences	45
The pleiotropic roles of eIF5A in cellular life and its therapeutic potential in cancer	43
Neurodevelopmental functions of CHD8: new insights and questions	41
Understanding immune signaling using advanced imaging techniques	40
Stop CRYing! Inhibition of cryptochrome function by small proteins	40
Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation	40
Do tunneling nanotubes drive chemoresistance in solid tumors and other malignancies?	38
Exploring the multifunctionality of SR proteins	37
Reconstituting membrane fission using a high content and throughput assay	35
Protein–protein and protein–lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation	34
Inflammatory cell death: how macrophages sense neighbouring cell infection and damage	34
The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI	33

Maximizing the performance of protein-based fluorescent biosensors	33
A dynamic role for transcription factors in restoring transcription through mitosis	32
LARP6 proteins in plants	32
The role of lipid scramblases in regulating lipid distributions at cellular membranes	32
Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions	32
Experimental systems for the analysis of mutational signatures: no ‘one-size-fits-all' solution	31
Aminoacyl-tRNA synthetase interactions in SARS-CoV-2 infection	31
Compatibility of termination mechanisms in bacterial transcription with inference on eukaryotic models	30
The role of autophagy-lysosomal pathway in motor neuron diseases	30
Writing and erasing O-GlcNAc from target proteins in cells	30
Regulatory spine RS3 residue of protein kinases: a lipophilic bystander or a decisive element in the small-molecule kinase inhibitor binding?	29
Structural switching of tubulin in the microtubule lattice	29
Exploring potential developmental origins of common neurodegenerative disorders	29
Deconstructing cancer with precision genome editing	29
Applications of Cryo-EM in small molecule and biologics drug design	29
Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity	29
Spo11: from topoisomerase VI to meiotic recombination initiator	28
The role of protein acetylation in regulating mitochondrial fusion and fission	28
Alpha-to-beta cell trans-differentiation for treatment of diabetes	28
The molecular mechanisms of diapause and diapause-like reversible arrest	28
The role of RHIM in necroptosis	28
Big data and artificial intelligence (AI) methodologies for computer-aided drug design (CADD)	28
Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease	28
Role of Yme1 in mitochondrial protein homeostasis: from regulation of protein import, OXPHOS function to lipid synthesis and mitochondrial dynamics	28
Conquer by cryo-EM without physically dividing	27
The SMN-ribosome interplay: a new opportunity for Spinal Muscular Atrophy therapies	27
Correction: Current Working Models of SMC-driven DNA-loop extrusion	27
Microglia extracellular vesicles: focus on molecular composition and biological function	27
Studying membrane proteins with MicroED	26
The long and the short of Periscope Proteins	26
S-acylation in apoptotic and non-apoptotic cell death: a central regulator of membrane dynamics and protein function	26
Functional characterisation of substrate-binding proteins to address nutrient uptake in marine picocyanobacteria	26
Transition from totipotency to pluripotency in mice: insights into molecular mechanisms	26
Are cachexia-associated tumors transmitTERS of ER stress?	26
Structural glycobiology – from enzymes to organelles	25
Efficiency and equity in origin licensing to ensure complete DNA replication	25
Encyclopaedia of eukaryotic DNA methylation: from patterns to mechanisms and functions	25
The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder	25
Last but not least: BFL-1 as an emerging target for anti-cancer therapies	25
Ribosomal RNA expansion segments and their role in ribosome biology	24
New insights into the structure and dynamics of the TOM complex in mitochondria	24
Proteolytic regulation of mitochondrial oxidative phosphorylation components in plants	24
The evolution and structure/function of bHLH–PAS transcription factor family	24
Ceramide microdomains: the major influencers of the sphingolipid media platform	22
Three-dimensional models of the lung: past, present and future: a mini review	22
The role of peroxidasin in solid cancer progression	22
Expect the unexpected: conventional and unconventional roles for cadherins in collective cell migration	22
CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact	22
Small regulatory RNAs in rice epigenetic regulation	22
Recent insights into the control of mitochondrial fission	22

Periodic pattern formation during embryonic development	22
Frankenstein Cas9: engineering improved gene editing systems	22
Bile acid metabolism and FXR-mediated effects in human cholestatic liver disorders	22
GCN2: roles in tumour development and progression	21
The octadecanoids: an emerging class of lipid mediators	21
Detergent-free systems for structural studies of membrane proteins	21
Unravelling the structural complexity of protein–lipid interactions with neutron reflectometry	21
Tetraspanins affect membrane structures and the trafficking of molecular partners: what impact on extracellular vesicles?	21
MsbA: an ABC transporter paradigm	21
Cryo-electron tomography: en route to the molecular anatomy of organisms and tissues	21
The role of glycosaminoglycan modification in Hedgehog regulated tissue morphogenesis	21
How neural stem cells contribute to neocortex development	21
Extracellular membrane particles en route to the nucleus – exploring the VOR complex	21
Inferiority complex: why do sensory ion channels multimerize?	20
Chemical biology approaches to study histone interactors	20
DNA methylation: from model plants to vegetable crops	20
How lipids affect the energetics of co-translational alpha helical membrane protein folding	20
Exploring cryo-electron microscopy with molecular dynamics	20
Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases	20
Molecular regulation of autophagosome formation	20
Voltage-clamp fluorometry for advancing mechanistic understanding of ion channel mechanisms with a focus on acid-sensing ion channels	19
Structural basis of molecular recognition among classical cadherins mediating cell adhesion	19
General strategies for using amino acid sequence data to guide biochemical investigation of protein function	19
Covalent activity-based probes for imaging of serine proteases	19
Uncovering novel regulators of memory using C. elegans genetic and genomic analysis	19
Novel roles for G protein-coupled receptor kinases in cardiac injury and repair	19
Biochemical approaches to assess the impact of post-translational modifications on pathogenic tau conformations using recombinant protein	18
IMPDH dysregulation in disease: a mini review	18
PIDD1 in cell cycle control, sterile inflammation and cell death	18
Correction: Fast-forward on P-type ATPases: recent advances on structure and function	18
Mre11–Rad50: the DNA end game	18
Improving photosynthesis through the enhancement of Rubisco carboxylation capacity	18
The central role of translation elongation in response to stress	18
Role of SWI/SNF chromatin remodeling genes in lung cancer development	18
DDX41: exploring the roles of a versatile helicase	18
Ion channels as convergence points in the pathology of pulmonary arterial hypertension	18
Research progress of ZIC5 for tumor metastasis	18
Biological insights from SMA-extracted proteins	17
The mechanisms of alkali therapy in targeting renal diseases	17
The role of caspases as executioners of apoptosis	17
Structural insights into the membrane-bound proteolytic machinery of bacterial protein quality control	17
AAA+ proteins: one motor, multiple ways to work	17
Sculpting with stiffness: rigidity as a regulator of morphogenesis	17
The mechanisms of class 1A PI3K and Wnt/β-catenin coupled signaling in breast cancer	17
Correction: Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity	16
Transcriptional bursting: from fundamentals to novel insights	16
Inorganic polyphosphate: from basic research to diagnostic and therapeutic opportunities in ALS/FTD	16
Artificial protein assemblies with well-defined supramolecular protein nanostructures	16
Organismal and cellular interactions in vertebrate–alga symbioses	16
The influence of high-order chromatin state in the regulation of stem cell fate	16
Targeting trypanosomes: how chemogenomics and artificial intelligence can guide drug discovery	16
Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury	16
Non-canonical roles of ATG8 for TFEB activation	16
How does the tubulin code facilitate directed cell migration?	16
Transcriptional control of neural stem cell activity	16
Understanding the role of ten-eleven translocation family proteins in kidney diseases	16
The role of pro-domains in human growth factors and cytokines	16
Plant supercomplex I + III2 structure and function: implications for the growing field	15
Exploring the structural dynamics of the vesicle priming machinery	15
Structural and functional approaches to studying cAMP regulation of HCN channels	15
Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation	15
Folding speeds of helical membrane proteins	15
The role of post-translational modifications in synaptic AMPA receptor activity	15
S-acylation of Ca2+ transport proteins: molecular basis and functional consequences	15
Chlamydia trachomatis invasion: a duet of effectors	15
Shaping epithelial lumina under pressure	15
LRRK2 along the Golgi and lysosome connection: a jamming situation	15
How do spherical bacteria regulate cell division?	14
Advances in understanding the mechanisms of the human papillomavirus oncoproteins	14
Suppression of double-stranded RNA sensing in cancer: molecular mechanisms and therapeutic potential	14
Gone with the Wnt(less): a mechanistic perspective on the journey of Wnt	14
Unusual modes of cell and nuclear divisions characterise Drosophila development	14
Organ-on-a-chip: current gaps and future directions	14
Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy	14
The art of hijacking: how Nsp1 impacts host gene expression during coronaviral infections	14
Revealing chromatin-specific functions of histone deacylases	14
The application of single-molecule optical tweezers to study disease-related structural dynamics in RNA	14
Understanding pyrethrin biosynthesis: toward and beyond natural pesticide overproduction	14
Regulation of the generation of reactive oxygen species during photosynthetic electron transport	14
Solid state NMR of membrane proteins: methods and applications	14

Genome organization across scales: mechanistic insights from in vitro reconstitution studies	14
Age-dependent regenerative mechanisms in the brain	14
Molecular and structural perspectives on protein trafficking to the primary cilium membrane	13
Satellite cell dynamics during skeletal muscle hypertrophy	13
Studying histone inheritance in different systems using imaging-based methods and perspectives	13
Bioengineering silk into blood vessels	13
U7 deciphered: the mechanism that forms the unusual 3′ end of metazoan replication-dependent histone mRNAs	13
Cell-free genomics: transcription factor interactions in reconstituted naïve embryonic chromatin	13
An update on the role of sex hormones in the function of the cardiorenal mitochondria	13
The interplay of helminthic neuropeptides and proteases in parasite survival and host immunomodulation	13
How far can omics go in unveiling the mechanisms of floral senescence?	13
Transcriptional control of ribosome biogenesis in yeast: links to growth and stress signals	13
Human E3 ubiquitin ligases: accelerators and brakes for SARS-CoV-2 infection	13
Lessons from natural molecular glue degraders	13
Npt2a as a target for treating hyperphosphatemia	13
Eliminating oncogenic RAS: back to the future at the drawing board	12
Bacterial microcompartments as a next-generation metabolic engineering tool: utilizing nature's solution for confining challenging catabolic pathways	12
Lipid–protein interactions in virus assembly and budding from the host cell plasma membrane	12
Regulation of mTORC1 by the Rag GTPases	12
Mechanisms of epithelial growth and development in the zebrafish intestine	12
Intersectin — many facets of a scaffold protein	12
Advancing our knowledge of antigen processing with computational modelling, structural biology, and immunology	12
Targeting NRF2 to promote epithelial repair	12
Polycomb-mediated histone modifications and gene regulation	12
Timely symbiosis: circadian control of legume-rhizobia symbiosis	12
GPX4: old lessons, new features	12
Computational approaches to understand transcription regulation in development	12
Striving for sustainable biosynthesis: discovery, diversification, and production of antimicrobial drugs in Escherichia coli	12
The emerging theme of 3′UTR mRNA isoform regulation in reprogramming of cell metabolism	12
Nano-organization of synaptic calcium signaling	12
The NEDD4 ubiquitin E3 ligase: a snapshot view of its functional activity and regulation	12
Specific isotopic labelling and reverse labelling for protein NMR spectroscopy: using metabolic precursors in sample preparation	12
A closer look at the role of deubiquitinating enzymes in the Hypoxia Inducible Factor pathway	12
Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens	12
One genome, multiple phenotypes: decoding the evolution and mechanisms of environmentally induced developmental plasticity in insects	12