Molecular Biology Reports

Article	Citations
Codon usage bias	141
Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19	128
Mobilized colistin resistance (mcr) genes from 1 to 10: a comprehensive review	126
Multidrug-resistant Acinetobacter baumannii as an emerging concern in hospitals	126
Molecular link between dietary fibre, gut microbiota and health	112
Recent advances on drug development and emerging therapeutic agents for Alzheimer’s disease	102
Silent hypoxia in COVID-19: pathomechanism and possible management strategy	100
Microalgae: therapeutic potentials and applications	98
A review on mechanism of inhibition of advanced glycation end products formation by plant derived polyphenolic compounds	68
Metallo-ß-lactamases: a review	65
Potential therapeutic and pharmacological effects of Wogonin: an updated review	63
Pharmacological and therapeutic applications of Sinapic acid—an updated review	61
Artemisinin and its derivatives: a promising cancer therapy	59
Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds	59
Molecular mechanism of action and pharmacokinetic properties of methotrexate	55
Telomere length: how the length makes a difference	55
Analyzing the regulatory role of heat shock transcription factors in plant heat stress tolerance: a brief appraisal	54
Interplay between PI3K/AKT pathway and heart disorders	49
An updated review of the H19 lncRNA in human cancer: molecular mechanism and diagnostic and therapeutic importance	48
Niclosamide for Covid-19: bridging the gap	47
ABC transporter superfamily. An updated overview, relevance in cancer multidrug resistance and perspectives with personalized medicine	46
Plant growth promoting Pseudomonas aeruginosa from Valeriana wallichii displays antagonistic potential against three phytopathogenic fungi	43
An update on vascular calcification and potential therapeutics	42
DNA barcoding, an effective tool for species identification: a review	42
Harnessing the immune system against cancer: current immunotherapy approaches and therapeutic targets	41

Tissue culture-induced DNA methylation in crop plants: a review	41
Hybrid of niosomes and bio-synthesized selenium nanoparticles as a novel approach in drug delivery for cancer treatment	40
Exogenous phytohormones in the regulation of growth and development of cereals under abiotic stresses	39
Role of melatonin in the treatment of COVID-19; as an adjuvant through cluster differentiation 147 (CD147)	38
Particle bombardment technology and its applications in plants	38
Substance P accelerates the progression of human esophageal squamous cell carcinoma via MMP-2, MMP-9, VEGF-A, and VEGFR1 overexpression	37
Understanding angiogenesis and the role of angiogenic growth factors in the vascularisation of engineered tissues	37
Vascular mimicry: changing the therapeutic paradigms in cancer	37
Psychedelics as an emerging novel intervention in the treatment of substance use disorder: a review	36
Molecular mechanisms of physical exercise on depression in the elderly: a systematic review	36
A contemporary review on pathogenesis and immunity of COVID-19 infection	36
Anti-inflammatory Activity of Bioactive Compounds from Microalgae and Cyanobacteria by Focusing on the Mechanisms of Action	35
Insulin signaling pathway assessment by enhancing antioxidant activity due to morin using in vitro rat skeletal muscle L6 myotubes cells	35
Anti-proliferative and ROS-inhibitory activities reveal the anticancer potential of Caulerpa species	35
Role and relevance of fish cell lines in advanced in vitro research	35
The effect of dietary phytochemicals on nuclear factor erythroid 2-related factor 2 (Nrf2) activation: a systematic review of human intervention trials	34
Matrix metalloproteinase contribution in management of cancer proliferation, metastasis and drug targeting	34
Insights in the biology of extremely low-frequency magnetic fields exposure on human health	33
The effects of hybridization and genome doubling in plant evolution via allopolyploidy	33
Endosomes, lysosomes, and the role of endosomal and lysosomal biogenesis in cancer development	32
Serum CGRP, VIP, and PACAP usefulness in migraine: a case–control study in chronic migraine patients in real clinical practice	32
Genome-wide identification of the ARF (auxin response factor) gene family in peach and their expression analysis	32
Molecular process of glucose uptake and glycogen storage due to hamamelitannin via insulin signalling cascade in glucose metabolism	31
Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue	31
Enteromorpha compressa extract induces anticancer activity through apoptosis and autophagy in oral cancer	31
Immune cell metabolism and metabolic reprogramming	31
Genetically modified crop regulations: scope and opportunity using the CRISPR-Cas9 genome editing approach	31
Caprylic acid ameliorates rotenone induced inflammation and oxidative stress in the gut-brain axis in Zebrafish	30
The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it?	30
Differential regulation of the durum wheat Pathogenesis-related protein (PR1) by Calmodulin TdCaM1.3 protein	30
MicroRNA signature in hepatocellular carcinoma patients: identification of potential markers	30
SARS-CoV-2 cell entry beyond the ACE2 receptor	30
An update on potential links between type 2 diabetes mellitus and Alzheimer’s disease	29
Intussusceptive angiogenesis in Covid-19: hypothesis on the significance and focus on the possible role of FGF2	29
Alternative splicing modulates cancer aggressiveness: role in EMT/metastasis and chemoresistance	28
Naringenin attenuates cell viability and migration of C6 glioblastoma cell line: a possible role of hedgehog signaling pathway	28
Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy	28
The natural flavones, acacetin and apigenin, induce Cdk-Cyclin mediated G2/M phase arrest and trigger ROS-mediated apoptosis in glioblastoma cells	27
Antibiotic resistance, biofilm production ability and genetic diversity of carbapenem-resistant Pseudomonas aeruginosa strains isolated from nosocomial infections in southwestern Iran	27
Ellagic acid prevents kidney injury and oxidative damage via regulation of Nrf-2/NF-κB signaling in carbon tetrachloride induced rats	27
Bone metastases: a comprehensive review of the literature	27
NRF2 modulation in TRAMP mice: an in vivo model of prostate cancer	27
Cardioprotective effects of resveratrol following myocardial ischemia and reperfusion	26
Anti-inflammatory activities of puerarin in high-fat diet-fed rats with streptozotocin-induced gestational diabetes mellitus	26
CRISPR/Cas9-mediated mutagenesis of WRKY3 and WRKY4 function decreases salt and Me-JA stress tolerance in Arabidopsis thaliana	26
Development and validation of heat-responsive candidate gene and miRNA gene based SSR markers to analysis genetic diversity in wheat for heat tolerance breeding	26
The role of miRNA in plant–virus interaction: a review	26
Transcriptome analysis of heat stress response genes in potato leaves	26
LncRNA as a multifunctional regulator in cancer multi-drug resistance	26
The role of AMPK in metabolism and its influence on DNA damage repair	26

Osteoblast role in the pathogenesis of rheumatoid arthritis	26
Current advances and challenges in COVID-19 vaccine development: from conventional vaccines to next-generation vaccine platforms	26
Metabolic changes in triple negative breast cancer-focus on aerobic glycolysis	25
Genome sequence analysis provides insights on genomic variation and late blight resistance genes in potato somatic hybrid (parents and progeny)	25
CRISPR based targeted genome editing of Chlamydomonas reinhardtii using programmed Cas9-gRNA ribonucleoprotein	25
Advances in exogenous RNA delivery techniques for RNAi-mediated pest control	25
M2-polarized macrophages mediate wound healing by regulating connective tissue growth factor via AKT, ERK1/2, and STAT3 signaling pathways	25
Do tumor exosome integrins alone determine organotropic metastasis?	25
Evaluation of the biocompatibility of the GSH-coated Ag2S quantum dots in vitro: a perfect example for the non-toxic optical probes	25
Mesenchymal stromal cell and bone marrow concentrate therapies for musculoskeletal indications: a concise review of current literature	25
Development of EST-SSR markers for genetic diversity analysis in coconut (Cocos nucifera L.)	24
Evaluation of oxidative stress, inflammation, apoptosis, oxidative DNA damage and metalloproteinases in the lungs of rats treated with cadmium and carvacrol	24
Salivary exosomes: properties, medical applications, and isolation methods	24
Codeine-induced hepatic injury is via oxido-inflammatory damage and caspase-3-mediated apoptosis	24
Treg cells in atherosclerosis	24
Recent advances in the application of probiotic yeasts, particularly Saccharomyces, as an adjuvant therapy in the management of cancer with focus on colorectal cancer	24
The deadly cross-talk between Hippo pathway and epithelial–mesenchymal transition (EMT) in cancer	24
Advances in the regulation of plant salt-stress tolerance by miRNA	23
Breast cancer in the era of precision medicine	23
The secretome of mesenchymal stem cells and oxidative stress: challenges and opportunities in cell-free regenerative medicine	23
Increased phenolic acid and tanshinone production and transcriptional responses of biosynthetic genes in hairy root cultures of Salvia przewalskii Maxim. treated with methyl jasmonate and salicylic ac	23
Nitazoxanide and COVID-19: A review	23
Molecular characterization and genetic diversity studies of Indian soybean (Glycine max (L.) Merr.) cultivars using SSR markers	23
Unfolding Nrf2 in diabetes mellitus	23
Plant miR171 modulates mTOR pathway in HEK293 cells by targeting GNA12	23
The critical role of the interplays of EphrinB2/EphB4 and VEGF in the induction of angiogenesis	23
Acacetin improves endothelial dysfunction and aortic fibrosis in insulin-resistant SHR rats by estrogen receptors	23
JAK/STAT pathway and molecular mechanism in bone remodeling	23
Genome-editing in millets: current knowledge and future perspectives	23
The PI3K/AKT/mTOR signaling pathway inhibitors enhance radiosensitivity in cancer cell lines	22
GRAS transcription factors emerging regulator in plants growth, development, and multiple stresses	22
DNA barcoding to characterize biodiversity of freshwater fishes of Egypt	22
Emerging role of N4-acetylcytidine modification of RNA in gene regulation and cellular functions	22
Signals in systemic acquired resistance of plants against microbial pathogens	22
Phosphorus homeostasis: acquisition, sensing, and long-distance signaling in plants	22
Genome-wide identification, characterization analysis and expression profiling of auxin-responsive GH3 family genes in wheat (Triticum aestivum L.)	22
MicroRNA-424-5p enhances chemosensitivity of breast cancer cells to Taxol and regulates cell cycle, apoptosis, and proliferation	22
Investigation of the role of quercetin as a heat shock protein inhibitor on apoptosis in human breast cancer cells	22
Quercetin, chrysin, caffeic acid and ferulic acid ameliorate cyclophosphamide-induced toxicities in SH-SY5Y cells	22
Urinary exosomal microRNA-96-5p and microRNA-183-5p expression as potential biomarkers of bladder cancer	22
The significance of the SDF-1/CXCR4 signaling pathway in the normal development	22
New insights on the role of autophagy in the pathogenesis and treatment of melanoma	22
Impact of heat stress responsive factors on growth and physiology of cotton (Gossypium hirsutum L.)	22
The potential impact of trigonelline loaded micelles on Nrf2 suppression to overcome oxaliplatin resistance in colon cancer cells	21
Deciphering the genetic diversity and population structure of Turkish bread wheat germplasm using iPBS-retrotransposons markers	21
SARS-COV-2 infection and lung tumor microenvironment	21
Pharmacological modulation of cytokines correlating neuroinflammatory cascades in epileptogenesis	21
Blocking TNF signaling may save lives in COVID-19 infection	21
Metformin and/or low dose radiation reduces cardiotoxicity and apoptosis induced by cyclophosphamide through SIRT-1/SOD and BAX/Bcl-2 pathways in rats	21
Pathological mechanism of joint destruction in haemophilic arthropathy	21
TGF-β promote epithelial-mesenchymal transition via NF‐κB/NOX4/ROS signal pathway in lung cancer cells	21
Trehalose: a promising osmo-protectant against salinity stress—physiological and molecular mechanisms and future prospective	21
Immunotherapy: an alternative promising therapeutic approach against cancers	21
Protective effect of Nasturtium officinale R. Br and quercetin against cyclophosphamide-induced hepatotoxicity in rats	21
Expatiating the molecular approaches of HMGB1 in diabetes mellitus: Highlighting signalling pathways via RAGE and TLRs	21
Clinical significance of dust mite allergens	21
Acute lymphoid leukemia etiopathogenesis	21
Characterization and validation of olive FAD and SAD gene families: expression analysis in different tissues and during fruit development	21
Dichloromethane fraction of Moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (MCF7) by induction of apoptosis via upregulation of Bax, p53 and caspase 8 expressions	21
Chemotherapy resistance and stromal targets in breast cancer treatment: a review	21
Mechanisms of resistance to cyclin-dependent kinase 4/6 inhibitors	20
miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells	20
Critical role of EphA3 in cancer and current state of EphA3 drug therapeutics	20
GDM-complicated pregnancies: focus on adipokines	20
Mechanism of tumour microenvironment in the progression and development of oral cancer	20
Methanolic extract of Artemisia absinthium prompts apoptosis, enhancing expression of Bax/Bcl-2 ratio, cell cycle arrest, caspase-3 activation and mitochondrial membrane potential destruction in human	20
The cell cycle, cancer development and therapy	20
Melatonin and vitamin E alleviate homocysteine‐induced oxidative injury and apoptosis in endothelial cells	20
The protective effects of resveratrol on ulcerative colitis via changing the profile of Nrf2 and IL-1β protein	20
Corticosteroids for COVID-19: worth it or not?	20
Integrating speed breeding with artificial intelligence for developing climate-smart crops	20
Recent advances in the nucleic acid-based diagnostic tool for coronavirus	20
Centaurea bruguierana inhibits cell proliferation, causes cell cycle arrest, and induces apoptosis in human MCF-7 breast carcinoma cells	19
Mechanism of progression of diabetic kidney disease mediated by podocyte mitochondrial injury	19
Unsaturated fatty acids as a co-therapeutic agents in cancer treatment	19
BRCA testing in a genomic diagnostics referral center during the COVID-19 pandemic	19
Anticancer activity of monoterpenes: a systematic review	19
Mass propagation through direct and indirect organogenesis in three species of genus Zephyranthes and ploidy assessment of regenerants through flow cytometry	19
Therapeutic potential of Nrf-2 pathway in the treatment of diabetic neuropathy and nephropathy	19
Gut microbiota-derived metabolites and their importance in neurological disorders	19

35S promoter-driven transgenes are variably expressed in different organs of Arabidopsis thaliana and in response to abiotic stress	19
Insights into the antitumor mechanism of ginsenosides Rg3	19
Vitamin D receptor (VDR) and metabolizing enzymes CYP27B1 and CYP24A1 in breast cancer	19
Genetic relationships and diversity analysis in Turkish laurel (Laurus nobilis L.) germplasm using ISSR and SCoT markers	19
Modulation of autophagy as the target of mesenchymal stem cells-derived conditioned medium in rat model of myocardial ischemia/reperfusion injury	19
Adipose derived mesenchymal stem cell treatment in experimental asherman syndrome induced rats	19
Berberine induces apoptosis in glioblastoma multiforme U87MG cells via oxidative stress and independent of AMPK activity	19
Molecular and computational analysis of spike protein of newly emerged omicron variant in comparison to the delta variant of SARS-CoV-2 in Iraq	19
CRISPR-Cas9 based stress tolerance: New hope for abiotic stress tolerance in chickpea (Cicer arietinum)	19
Fatty acid desaturases (FADs) modulate multiple lipid metabolism pathways to improve plant resistance	19
COVID-19-associated-mucormycosis: possible role of free iron uptake and immunosuppression	19
Allicin induces cell cycle arrest and apoptosis of breast cancer cells in vitro via modulating the p53 pathway	19
Long non-coding RNA-based glycolysis-targeted cancer therapy: feasibility, progression and limitations	18
Phytopathogenic oomycetes: a review focusing on Phytophthora cinnamomi and biotechnological approaches	18
Review on NAD(P)H dehydrogenase quinone 1 (NQO1) pathway	18
Utilization of genetic diversity and marker-trait to improve drought tolerance in rice (Oryza sativa L.)	18
The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions	18
N-glycosylation, a leading role in viral infection and immunity development	18
The AKR1B1 inhibitor epalrestat suppresses the progression of cervical cancer	18
Therapeutic potential of neurotrophic factors in Alzheimer’s Disease	18
Argonaute proteins: structures and their endonuclease activity	18
The expression of Terpenoid Indole Alkaloid (TIAs) pathway genes in Catharanthus roseus in response to salicylic acid treatment	18
Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats	18
Comparative transcriptome profiling of rice colonized with beneficial endophyte, Piriformospora indica, under high salinity environment	18
Evaluation of genetic diversity by morphological, biochemical and molecular markers in sour cherry genotypes	18
Advances of exosome isolation techniques in lung cancer	18
A novel freshwater cyanophage vB_MelS-Me-ZS1 infecting bloom-forming cyanobacterium Microcystis elabens	18
Emerging functions of adipokines in linking the development of obesity and cardiovascular diseases	18
Emerging role of long non-coding RNAs in cancer chemoresistance: unravelling the multifaceted role and prospective therapeutic targeting	18
Overexpression of LeNHX4 improved yield, fruit quality and salt tolerance in tomato plants (Solanum lycopersicum L.)	18
siRNA-mediated silencing of CD44 delivered by Jet Pei enhanced Doxorubicin chemo sensitivity and altered miRNA expression in human breast cancer cell line (MDA-MB468)	18
CRISPR-Cas technology based genome editing for modification of salinity stress tolerance responses in rice (Oryza sativa L.)	18
Astragalin attenuates oxidative stress and acute inflammatory responses in carrageenan-induced paw edema in mice	18
Heat shock proteins with an emphasis on HSP 60	18
Protective effect of morin by targeting mitochondrial reactive oxygen species induced by hydrogen peroxide demonstrated at a molecular level in MDCK epithelial cells	18
Lauric acid alleviates insulin resistance by improving mitochondrial biogenesis in THP-1 macrophages	18
Aging and its treatment with vitamin C: a comprehensive mechanistic review	18
Neuroprotection with Bacopa monnieri–A review of experimental evidence	18
Biotic stress triggered small RNA and RNAi defense response in plants	18
An updated review on the role of the CXCL8-CXCR1/2 axis in the progression and metastasis of breast cancer	17
Fabrication and evaluation of aptamer-conjugated paclitaxel-loaded magnetic nanoparticles for targeted therapy on breast cancer cells	17
Early growth response 1 (EGR1) activation in initial stages of host–pathogen interactions	17
Apolipoprotein C-III and cardiovascular diseases: when genetics meet molecular pathologies	17
Prophylactic effect of myricetin and apigenin against lipopolysaccharide-induced acute liver injury	17
Ribosomal protein S3 selectively affects colon cancer growth by modulating the levels of p53 and lactate dehydrogenase	17
Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis	17
Sericin modulates learning and memory behaviors by tuning of antioxidant, inflammatory, and apoptotic markers in the hippocampus of aged mice	17
Necroptosis and RhoA/ROCK pathways: molecular targets of Nesfatin-1 in cardioprotection against myocardial ischemia/reperfusion injury in a rat model	17
Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis	17
Neutralizing antibody: a savior in the Covid-19 disease	17
Zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response	17
RNA sequencing and its applications in cancer and rare diseases	17
Selection and evaluation of reference genes for qRT-PCR of Scutellaria baicalensis Georgi under different experimental conditions	17
Expression analysis of defense-related genes in cucumber (Cucumis sativus L.) against Phytophthora melonis	17
Liquid biopsy approaches for pleural effusion in lung cancer patients	17
Fingerprint identification of white clover cultivars based on SSR molecular markers	17
The enzymology of human eicosanoid pathways: the lipoxygenase branches	17
Potential in vitro therapeutic effects of targeting SP/NK1R system in cervical cancer	17
Circulating exosomal MicroRNAs: New non-invasive biomarkers of non-communicable disease	16
Evolutionary history of the heat shock protein 90 (Hsp90) family of 43 plants and characterization of Hsp90s in Solanum tuberosum	16
Synthetic curcumin analog: inhibiting the invasion, angiogenesis, and metastasis in human laryngeal carcinoma cells via NF-kB pathway	16
Improving Zinc and Iron Biofortification in Wheat through Genomics Approaches	16
Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal	16
Indole glucosinolates exhibit anti-inflammatory effects on Ehrlich ascites carcinoma cells through modulation of inflammatory markers and miRNAs	16
Prevalence of resistance genes to biocides in antibiotic-resistant Pseudomonas aeruginosa clinical isolates	16
Circulating levels of asprosin and its association with insulin resistance and renal function in patients with type 2 diabetes mellitus and diabetic nephropathy	16
Molecular mechanisms involved in the prevention and reversal of ketamine-induced schizophrenia-like behavior by rutin: the role of glutamic acid decarboxylase isoform-67, cholinergic, Nox-2-oxidative	16
Analysis of genetic diversity among common bean germplasm by start codon targeted (SCoT) markers	16
Mediation of induced systemic resistance by the plant growth-promoting rhizobacteria Bacillus pumilus S2-3-2	16
Resolvin D1 and E1 promote resolution of inflammation in rat cardiac fibroblast in vitro	16
Berberine reverses epithelial-mesenchymal transition and modulates histone methylation in osteosarcoma cells	16
Cross-talk between non-coding RNAs and PI3K/AKT/mTOR pathway in colorectal cancer	16
Exploring the molecular approach of COX and LOX in Alzheimer’s and Parkinson’s disorder	16
Resolving the equation between mucormycosis and COVID-19 disease	16
16S rRNA gene profiling of rhizospheric microbial community of Eichhornia crassipes	16
Identification of NCAPH as a biomarker for prognosis of breast cancer	16
Recent advances in cellular effects of fluoride: an update on its signalling pathway and targeted therapeutic approaches	16
mTOR-Rictor-EGFR axis in oncogenesis and diagnosis of glioblastoma multiforme	16
Deciphering carbohydrate metabolism during wheat grain development via integrated transcriptome and proteome dynamics	15
Recent advances of the biological and biomedical applications of CRISPR/Cas systems	15
Pro-inflammatory cytokine molecules from Boswellia serrate suppresses lipopolysaccharides induced inflammation demonstrated in an in-vivo zebrafish larval model	15
The effect of subacute poisoning with fenpropathrin on mice kidney function and the level of interleukin 1β and tumor necrosis factor α	15
Quercetin ameliorates lipopolysaccharide-induced neuroinflammation and oxidative stress in adult zebrafish	15
Anticancer and apoptotic activities of parthenolide in combination with epirubicin in mda-mb-468 breast cancer cells	15
Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell death pathways	15
Nanosized paclitaxel-loaded niosomes: formulation, in vitro cytotoxicity, and apoptosis gene expression in breast cancer cell lines	15
Betaine effects against asthma-induced oxidative stress in the liver and kidney of mice	15
Emergence of multidrug-resistant Shigella species harboring extended-spectrum beta-lactamase genes in pediatric patients with diarrhea from southwest of Iran	15
Transcriptome-wide identification and characterization of the Rab GTPase family in mango	15
Role of microRNAs in epidermal growth factor receptor signaling pathway in cervical cancer	15
Renal proximal tubular epithelial cells: review of isolation, characterization, and culturing techniques	15
Seminal plasma miRNAs in Klinefelter syndrome and in obstructive and non-obstructive azoospermia	15
Synthetic β-hydroxy ketone derivative inhibits cholinesterases, rescues oxidative stress and ameliorates cognitive deficits in 5XFAD mice model of AD	15
Natural polyphenols: a promising bioactive compounds for skin care and cosmetics	15
An evaluation of the molecular mode of action of trans-resveratrol in the Porphyromonas gingivalis lipopolysaccharide challenged neuronal cell model	15