Cell and Tissue Research

Papers
(The median citation count of Cell and Tissue Research is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)
ArticleCitations
New developments in prion disease research109
Prion assemblies: structural heterogeneity, mechanisms of formation, and role in species barrier68
Nescient helix-loop-helix 1 (Nhlh1) is a novel activating transcription factor 5 (ATF5) target gene in olfactory and vomeronasal sensory neurons in mice51
Orphan gene expressed in flame cone cells uniquely found in seahorse epithelium50
Genetically engineered cellular models of prion propagation49
The heterogeneity of erythroid cells: insight at the single-cell transcriptome level48
Role of capillary rarefaction in age-related changes of external urethral sphincter muscle of female mice44
Ascl1-expressing cell differentiation in initially developed taste buds and taste organoids40
Pituitary luteinizing hormone synthesis starts in aromatase (cyp19a1b)-positive cells expressing esr1 and esr2b at the onset of puberty in Takifugu rubripes (fugu)39
Simvastatin promotes rat Achilles tendon-bone interface healing by promoting osteogenesis and chondrogenic differentiation of stem cells38
Type 2 vomeronasal receptor expression in the olfactory organ of African lungfish, Protopterus annectens36
Correction to: Microtubule organization and tubulin post‑translational modifications in intact tissues and during regeneration in calcareous sponges36
An ultrastructural study of the deep pineal gland of the Sprague Dawley rat using transmission and serial block face scanning electron microscopy: cell types, barriers, and innervation29
Ontogenetic development of the water channel protein AQP5 in mouse salivary gland tissue29
Comparative study on a novel lobule structure of the zebrafish liver and that of the mammalian liver29
Platelet-derived growth factor signaling in porcine testicular tubular somatic cells28
Protective effect of alogliptin against cyclophosphamide-induced lung toxicity in rats: Impact on PI3K/Akt/FoxO1 pathway and downstream inflammatory cascades27
Lactate-induced effects on bovine granulosa cells are mediated via PKA signaling26
Olfactory receptors and human diseases26
Requirement for PINCH in skeletal myoblast differentiation25
Ultrastructure of dorsal root ganglia24
Screening for polystyrene nanoparticle toxicity on kidneys of adult male albino rats using histopathological, biochemical, and molecular examination results23
Kidney organoids: current knowledge and future directions22
Huogu injection protects against SONFH by promoting osteogenic differentiation of BMSCs and preventing osteoblast apoptosis21
Parvin is essential for indirect flight muscle (IFM) performance and Zasp52 localisation to the Z-disc in Drosophila melanogaster20
Engineering strategies towards overcoming bleeding and glial scar formation around neural probes20
Transcriptomic and ultrastructural evidence indicate that anti-HMGB1 antibodies rescue organic dust-induced mitochondrial dysfunction20
mTORC1/rpS6 and mTORC2/PKC regulate spermatogenesis through Arp3-mediated actin microfilament organization in Eriocheir sinensis20
Prion strains viewed through the lens of cryo-EM20
Lipoprotein-induced cell growth and hemocyanin biosynthesis in rhogocytes20
Hsa-MiR-483 -3p regulates the extracellular matrix proteins via TGFβ2/SMAD4 signaling in the glucocorticoid-responsive human trabecular meshwork cells20
Obesity-driven musculotendinous remodeling impairs tissue resilience to mechanical damage19
Recent advances in bioengineered scaffold for in vitro meat production19
Effectiveness of exosome mediated miR-126 and miR-146a delivery on cardiac tissue regeneration18
Neurotoxic stimulation alters prosaposin levels in the salivary systems of rats18
Mice lacking DCAF2 in placenta die at the gastrulation stage18
Klaus Unsicker: in honor of his eightieth birthday18
Impact of endogenous and exogenous nitrogen species on macrophage extracellular trap (MET) formation by bone marrow–derived macrophages18
An in-depth review of the function of RNA-binding protein FXR1 in neurodevelopment17
Correction to: Sertoli cell–conditioned medium restores spermatogenesis in azoospermic mouse testis17
A novel decellularized nerve graft for repairing peripheral nerve long gap injury in the rat17
Regeneration in calcareous sponge relies on ‘purse-string’ mechanism and the rearrangements of actin cytoskeleton17
Long non-coding RNA HOX transcript antisense intergenic RNA depletion protects against alcoholic hepatitis through the microRNA-148a-3p/sphingosine 1-phosphate receptor 1 axis17
Inflammatory gene silencing in activated monocytes by a cholesterol tagged-miRNA/siRNA: a novel approach to ameliorate diabetes induced inflammation16
LncRNA KCNQ10T1 shuttled by bone marrow mesenchymal stem cell-derived exosome inhibits sepsis via regulation of miR-154-3p/RNF19A axis16
Biofabrication, biochemical profiling, and in vitro applications of salivary gland decellularized matrices via magnetic bioassembly platforms16
Prion disease modelled in Drosophila15
The ability of remaining glomerular podocytes to adapt to the loss of their neighbours decreases with age15
Dynamic changes in endoplasmic reticulum morphology and its contact with the plasma membrane in motor neurons in response to nerve injury15
Region specificity of fibroblast-like cells in the mucosa of the rat large intestine15
Biological nerve conduit model with de-epithelialized human amniotic membrane and adipose-derived mesenchymal stem cell sheet for repair of peripheral nerve defects15
Repetitive and zonal expression profiles of absorption-related genes in the gastrointestinal tract of ascidian Ciona intestinalis type A15
KDELR2 promotes bone marrow mesenchymal stem cell osteogenic differentiation via GSK3β/β-catenin signaling pathway15
Discovery of a novel marker for human granulocytes and tissue macrophages: RTL1 revisited15
Caffeine protects against hippocampal alterations in type 2 diabetic rats via modulation of gliosis, inflammation and apoptosis14
Immune microenvironment: novel perspectives on bone regeneration disorder in osteoradionecrosis of the jaws14
miR-124-3p regulates the proliferation and differentiation of retinal progenitor cells through SEPT1014
The role of copper chromite nanoparticles on physical and bio properties of scaffolds based on poly(glycerol-azelaic acid) for application in tissue engineering fields14
Exploring the contribution of Zfp521/ZNF521 on primary hematopoietic stem/progenitor cells and leukemia progression14
Modulation of matrix metalloproteases by ciliary neurotrophic factor in human placental development14
mTORC1/C2 regulate spermatogenesis in Eriocheir sinensis via alterations in the actin filament network and cell junctions14
Beyond animal models: revolutionizing neurodegenerative disease modeling using 3D in vitro organoids, microfluidic chips, and bioprinting14
Identification of vagal afferent nerve endings in the mouse colon and their spatial relationship with enterochromaffin cells13
The dermal papilla dilemma and potential breakthroughs in bioengineering hair follicles13
NECL2 regulates blood–testis barrier dynamics in mouse testes13
Plasma-derived extracellular vesicles transfer microRNA-130a-3p to alleviate myocardial ischemia/reperfusion injury by targeting ATG16L113
Yearning for machine learning: applications for the classification and characterisation of senescence12
Cholesterol and its reciprocal association with prion infection12
Novel animal model of soft tissue tumor due to aberrant hedgehog signaling activation in pericyte lineage12
Tooth-derived stem cells integrated biomaterials for bone and dental tissue engineering12
Rab11 negatively regulates wingless preventing JNK-mediated apoptosis in Drosophila epithelium during embryonic dorsal closure12
Therapeutic strategies for identifying small molecules against prion diseases12
Organoids for modeling prion diseases12
Developmental roles of glomerular epithelial protein-1 in mice molar morphogenesis12
Esomeprazole inhibits hypoxia/endothelial dysfunction–induced autophagy in preeclampsia12
Lung organoids: current strategies for generation and transplantation12
Acknowledgement to reviewers12
Distribution, quantification, and characterization of substance P enteric neurons in the submucosal and myenteric plexuses of the porcine colon12
ER morphological analysis associated with interstitial cells of Cajal and smooth muscle cells in the murine stomach12
Unveiling the role of protein kinase A (PKA) activity in bovine oviductal epithelial cells: implications on apoptotic signaling pathways during the estrous cycle11
Mechanical stimulation promotes the maturation of cardiomyocyte-like cells from P19 cells and the function in a mouse model of myocardial infarction11
MicroRNA-29b targets ADAM12 and 19 to regulate the extracellular matrix in lamina cribrosa cells11
Liquid–liquid phase separation in normal hematopoiesis and hematological diseases11
LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function10
HMGB1 accumulation in cytoplasm mediates noise-induced cochlear damage10
Histological study of diurnal changes in bacterial settlement in the rat alimentary tract10
Osteopontin mediates the formation of corpora amylacea-like structures from degenerating neurons in the CA1 region of the rat hippocampus after ischemia10
Tumour necrosis factor alpha, interleukin 1 beta and interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell–derived factors10
A mammalian gonadotropin-inhibitory hormone homolog RFamide-related peptide 3 regulates pain and anxiety in mice10
Potential of animal-welfare compliant and sustainably sourced serum from pig slaughter blood10
Kidney organoids in translational research: disease modeling, drug discovery, and unresolved challenges10
Oxidative stress in asthma pathogenesis: mechanistic insights and implications for airway smooth muscle dysfunction10
Morphological and histochemical characteristics of the foregut, midgut, and hindgut, and their alterations during ovarian development in female freshwater prawn, Macrobrachium rosenbergii10
Long noncoding RNA XIST inhibition promotes Leydig cell apoptosis by acting as a competing endogenous RNA for microRNA-145a-5p that targets SIRT1 in late-onset hypogonadism10
MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion10
More than a simple epithelial layer: multifunctional role of echinoderm coelomic epithelium10
Entry of cannabidiol into the fetal, postnatal and adult rat brain10
Central nervous system regeneration in ascidians: cell migration and differentiation10
SPATA33 affects the formation of cell adhesion complex by interacting with CTNNA3 in TM4 cells10
Cellular heterogeneity in red and melanized focal muscle changes in farmed Atlantic salmon (Salmo salar) visualized by spatial transcriptomics9
Differential expression of villin and advillin by neuroendocrine and tuft cells in the murine lower airways9
Immortalized cell lines derived from dental/odontogenic tissue9
RT-QuIC as ultrasensitive method for prion detection9
The role of vitamin D receptor in predentin mineralization and dental repair after injury9
Cell biology of prion strains in vivo and in vitro9
Smarter stem cells: how AI is supercharging iPSC technology9
Epigenetic memory as crucial contributing factor in directing the differentiation of human iPSC into pancreatic β-cells in vitro9
Tissue-specific differences impacts therapeutic outcomes of mitochondrial transplantation through regulation of bioenergetics in metabolic syndrome9
Prion strains: shining new light on old concepts9
Epithelial-mesenchymal transition process during embryo implantation9
Exploring Nrf2 as a therapeutic target in testicular dysfunction9
Non-human primates in prion diseases8
Retraction Note: Guanabenz mitigates the neuropathological alterations and cell death in Alzheimer’s disease8
Nitric oxide mediated kisspeptin regulation of steroidogenesis and gametogenesis in the catfish, Clarias batrachus8
The orphan MRGPRF receptor is expressed in entero-endocrine cells of the human gut mucosa8
Regulation of Aqp1 expression by osmotic balance in fenestrated endothelial cells of the posterior lobe of the pituitary8
Gene duplication of C-type natriuretic peptide-4 (CNP4) in teleost lineage elicits subfunctionalization of ancestral CNP8
Correction to: A novel decellularized nerve graft for repairing peripheral nerve long gap injury in the rat8
The three-dimensional conformation and activity of mitochondria in syncytial male germ line-cysts of medicinal leeches8
Innexin expression and localization in the Drosophila antenna indicate gap junction or hemichannel involvement in antennal chemosensory sensilla8
The large milkweed bugs’ Na,K-ATPase β-subunits colocalize with septate junction proteins in a tissue-specific manner8
Mesenchymal stem cells ameliorate cisplatin-induced acute kidney injury via let-7b-5p8
Involvement of vimentin- and BLBP-positive glial cells and their MMP expression in axonal regeneration after spinal cord transection in goldfish8
Neurological confirmation of periplanone-D exploitation as a primary sex pheromone and counteractions of other components in the smoky brown cockroach Periplaneta fuliginosa8
Correction to: Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion8
DjsoxP-1 and Djsox5 are essential for tissue homeostasis and regeneration in Dugesia japonica8
Suppression of MALAT1 promotes human synovial mesenchymal stem cells enhance chondrogenic differentiation and prevent osteoarthritis of the knee in a rat model via regulating miR-212-5p/MyD88 axis8
Regeneration of starfish radial nerve cord restores animal mobility and unveils a new coelomocyte population8
Statistical study of clinical trials with stem cells and their function in skin wound8
Proteoglycan 4 is present within the dura mater and produced by mesenchymal progenitor cells7
Correction to: Loss‑of‑function manipulations to identify roles of diverse glia and stromal cells during CNS scar formation7
Influence of type 2 diabetes and obesity on adipose mesenchymal stem/stromal cell immunoregulation7
The hematopoietic tissue of the freshwater crayfish, Pacifastacus leniusculus: organization and expression analysis7
Human umbilical cord-derived mesenchymal stem cells ameliorate psoriasis-like dermatitis by suppressing IL-17-producing γδ T cells7
Systematic comparisons of various markers for mast cell activation in RBL-2H3 cells7
The larval midgut of Anopheles, Aedes, and Toxorhynchites mosquitoes (Diptera, Culicidae): a comparative approach in morphophysiology and evolution7
Single cell transcriptomics profiling of the stromal cells in the pathologic association of ribosomal proteins in the ischemic myocardium and epicardial fat7
Extracellular matrix in intervertebral disc: basic and translational implications7
High fat diet induces brain injury and neuronal apoptosis via down-regulating 3-β hydroxycholesterol 24 reductase (DHCR24)7
The ameliorating effects of adipose-derived stromal vascular fraction cells on blue light-induced rat retinal injury via modulation of TLR4 signaling, apoptosis, and glial cell activity7
Bioactive extracellular matrix fragments in tendon repair7
Fibulin-4 is required for the mechanical stability of tendons7
The presence and distribution of gamma-aminobutyric acid and dopamine during the developmental stages of the sea cucumber, Holothuria scabra, with emphasis on settlement organs7
Diabetes compromises tight junction protein claudin 14 in the urinary bladder7
Correction to: Modulation of matrix metalloproteases by ciliary neurotrophic factor in human placental development7
Collagen II and decellularized hyaline cartilage scaffolds derived from bovine trachea differentially promote chondrogenic differentiation of mesenchymal stem cells and decrease secretion of angiogeni7
Oxygen supplementation to limit hypoxia-induced muscle atrophy in C2C12 myotubes: comparison with amino acid supplement and electrical stimulation7
Characteristics of A-type voltage-gated K+ currents expressed on sour-sensing type III taste receptor cells in mice7
Combined effect of naringin and adipose tissue-derived mesenchymal stem cell on cisplatin nephrotoxicity through Sirtuin1/Nrf-2/HO-1 signaling pathway: a promising nephroprotective candidate7
Restoration of functional PAX3 transcriptional factor enhanced neuronal differentiation in PAX3b isoform-depleted neuroblastoma cells7
Exosomes from adipose-derived stem cells activate sebocytes through the PI3K/AKT/SREBP-1 pathway to accelerate wound healing7
Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava7
Integration of transcriptomics and metabolomics reveals pathways involved in MDSC supernatant attenuation of TGF-β1-induced myofibroblastic differentiation of mesenchymal stem cells7
Yap/Taz activity is associated with increased expression of phosphoglycerate dehydrogenase that supports myoblast proliferation6
Sex steroid hormone synthesis, metabolism, and the effects on the mammalian olfactory system6
Proteomic analysis of secreted proteins derived from amniotic fluid stem cells6
PDLIM1 interacts with HK2 to promote gastric cancer progression through enhancing the Warburg effect via Wnt/β-catenin signaling6
Hyperlipidemia in tendon injury: chronicles of low-density lipoproteins6
Identification of MrgprD expression in mouse enteric neurons6
Olfactory and gustatory chemical sensor systems in the African turquoise killifish: Insights from morphology6
Correction to: Transplantation of R-GSIK scaffold with mesenchymal stem cells improves neuroinflammation in a traumatic brain injury model6
Missing pieces of the pituitary puzzle: participation of extra-adenohypophyseal placode-lineage cells in the adult pituitary gland6
MicroRNAs in atrial fibrillation target genes in structural remodelling6
Development of a 3D in vitro model to study corpus luteum of felids based on luteinized cells from antral follicles6
A re-appraisal of mesenchymal-epithelial transition (MET) in endometrial epithelial remodeling6
Stem cell transplantation as a progressing treatment for retinitis pigmentosa6
Attenuation of intestinal peristalsis with age is attributed to decreased sensitivity of receptors in the enteric nervous system6
Effects of mesenchymal stem cell transplantation on spinal cord injury patients6
Steps of spermiogenesis in the ostrich (Struthio camelus)6
Upregulation of Profilin 2 on HDAC6 overexpression in mouse GC-1 cells and its putative role in germ cell migration in the testis6
Involvement of connexin 43 in myocardial ischemia–reperfusion injury6
Tumor necrosis factor-α and matrix metalloproteinase-9 cooperatively exacerbate neurovascular degeneration in the neonatal rat retina6
Folliculogenesis and follicular growth in the endangered fish Brycon opalinus, with emphasis on ovarian matrix remodeling6
Extra-oral expression of bitter taste receptors in pigs and their correlation with hepatic cytochrome P450 enzymes6
Immobilization management of acute phase increases healing ligament strength6
Spatial arrangement, polarity, and posttranslational modifications of the microtubule system in the Drosophila eye6
Identification of the zebrafish homologues of IMPG2, a retinal proteoglycan6
Distribution of glutathione peroxidase-1 immunoreactive cells in pancreatic islets from type 1 diabetic donors and non-diabetic donors with and without islet cell autoantibodies is variable and indepe5
A brief history of insect neuropeptide and peptide hormone research5
Evidence for RA-dependent meiosis onset in a turtle embryo5
Expression analysis of peptidergic enteroendocrine cells in the silkworm Bombyx mori5
Effect of expansion of human umbilical cord blood CD34 + cells on neurotrophic and angiogenic factor expression and function5
Immunohistochemical relationships of huntingtin-associated protein 1 with choline acetyltransferase in the forebrain cholinergic nuclei of adult mice5
The possible protective effect of luteolin on cardiovascular and hepatic changes in metabolic syndrome rat model5
Challenges of mesenchymal stem cells in the clinical treatment of COVID-195
Analysis of the spinal and vagal afferent innervation of the mouse colon using neuronal retrograde tracers5
Phagophores originate from endoplasmic reticulum membranes in vasopressin neurons in a mouse model of familial neurohypophysial diabetes insipidus5
Role of chondroitin sulfate in the developmental and healing process of the dental pulp in mice5
Morphology and ultrastructure of digestive system in pre-zoea and zoea I larvae of red king crab, Paralithodes camtschaticus (Tilesius, 1815)5
ETS1 promotes the expression of Ctsb and Mmp13 during the differentiation of septoclasts from pericytes5
Expansion microscopy in honeybee brains for high-resolution neuroanatomical analyses in social insects5
Prepubertal nutritional modulation in the bull and its impact on sperm DNA methylation5
Differential gene expression and hallmarks of stemness in epithelial cells of the developing rat epididymis5
Expression patterns of sex steroid receptors in developing mesonephros of the male mouse: three-dimensional analysis5
Comparative study on a unique architecture of the brook lamprey liver and that of the hagfish and banded houndshark liver5
Comparative transcriptomic and phenotypic analysis of induced pluripotent stem cell hepatocyte-like cells and primary human hepatocytes5
Development of branchial ionocytes in embryonic and larval stages of cloudy catshark, Scyliorhinus torazame5
Retraction Note to: Preconditioning with melatonin improves therapeutic outcomes of bone marrow-derived mesenchymal stem cells in targeting liver fibrosis induced by CCl45
Mechanisms of prion-induced toxicity5
Gross anatomy of the visual processing centers of Hieroglyphus banian5
Regional differences in the ultrastructure of mucosal macrophages in the rat large intestine5
Gene expression and epigenetic markers of prion diseases4
Paracrine and endocrine pathways of natriuretic peptides assessed by ligand-receptor mapping in the Japanese eel brain4
Platelet lysate can support the development of a 3D-engineered skin for clinical application4
The role and mechanism of Schwann cells in the repair of peripheral nerve injury4
Anatomical and molecular insights into the antennal gland of the giant freshwater prawn Macrobrachium rosenbergii4
Exploration of eMSCs with HA-GEL system in repairing damaged endometrium after endometrial cancer with fertility-sparing treatment4
Oct4 facilitates chondrogenic differentiation of mesenchymal stem cells by mediating CIP2A expression4
Brain morphology in the peracarid crustacean Neomysis integer (Leach, 1814) with an emphasis on sexual dimorphism of the olfactory pathway4
Toll-like receptor 10 has a role in human macrophage response against Streptococcus pneumoniae4
Exploring the antiangiogenic effects of Phospholipases A2 from Bothrops diporus venom4
Spatiotemporal analysis of multi-scale cell structure in spheroid culture reveals hypertrophic chondrocyte differentiation4
Microtubule organization and tubulin post-translational modifications in intact tissues and during regeneration in calcareous sponges4
Inhibition of BCAT1 expression improves recurrent miscarriage by regulating cellular dysfunction and inflammation of trophoblasts4
A histological study of vascular wall resident stem cells in venous malformations4
Differential expression of neuropeptide F in the digestive organs of female freshwater prawn, Macrobrachium rosenbergii, during the ovarian cycle4
Rheb1 is required for limb growth through regulating chondrogenesis in growth plate4
New developments in prion disease research using genetically modified mouse models4
Multi-regional expression of pancreas-related digestive enzyme genes in the intestinal chamber of the ascidian Ciona intestinalis type A4
Correction to: Nescient helix-loop-helix 1 (Nhlh1) is a novel activating transcription factor 5 (ATF5) target gene in olfactory and vomeronasal sensory neurons in mice4
Correction to: Cellular heterogeneity in red and melanized focal muscle changes in farmed Atlantic salmon (Salmo salar) visualized by spatial transcriptomics4
Essential roles of YAP-TEAD complex in adult stem cell development during thyroid hormone-induced intestinal remodeling of Xenopus laevis4
Correction to: Guanabenz mitigates the neuropathological alterations and cell death in Alzheimer’s disease4
Hypoxia pretreatment enhances the therapeutic potential of mesenchymal stem cells (BMSCs) on ozone-induced lung injury in rats4
Mechanically induced histochemical and structural damage in the annulus fibrosus and cartilaginous endplate: a multi-colour immunofluorescence analysis4
LncRNA LINC01197 inhibited the formation of calcium oxalate-induced kidney stones by regulating miR-516b-5p/SIRT3/FOXO1 signaling pathway4
Autophagy-related DjAtg1-1 plays critical role in planarian regeneration by regulating proliferation and cell death4
Photoneuroendocrine, circadian and seasonal systems: from photoneuroendocrinology to circadian biology and medicine4
Functionalised biomaterials as synthetic extracellular matrices to promote vascularisation and healing of diabetic wounds4
Emergence of the sex difference in calbindin D-28K neurons and the role of calbindin D-28K in clustering neurons of the preoptic area in mice4
Structure of putative epidermal sensory receptors in an acoel flatworm, Praesagittifera naikaiensis4
A new organisational design in skeletal muscle fibres4
Nanobody-based Pannexin1 channel inhibitors increase survival after cardiac ischemia/reperfusion4
Immunohistochemical localisation of vasopressin/oxytocin-type, corazonin-type and luqin-type neuropeptide expression in the starfish Asterias rubens using antibodies to the C-terminal region of precur4
Extracellular vesicles with diagnostic and therapeutic potential for prion diseases4
Ovarian tissue cryopreservation and transplantation: a review on reactive oxygen species generation and antioxidant therapy4
Correlation of the regenerative potential of dermal fibroblasts in 2D culture with the biological properties of fibroblast-derived tissue spheroids4
Miniature-swine iPSC-derived GABA progenitor cells function in a rat Parkinson’s disease model4
HDAC5 inactivates CYR61-regulated CD31/mTOR axis to prevent the occurrence of preeclampsia4
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