OOIR: Observatory of International Research

Papers

(The H4-Index of Cancer Letters is 66. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Editorial Board	191
Sphingosine-1 phosphate receptor 1 (S1PR1) expression maintains stemness of acute myeloid leukemia stem cells	189
Versatility of Exosomes for Cancer Therapy	181
Bypassing the Tollway; a novel path to TLR4 independent stemness regulation	179
Ethnic Diversity and Metabolic Variations in Ovarian Cancer Cells: Implications for Personalized Medicine Strategies	174
Editorial Board	172
Corrigendum to “Selective degradation of FGFR1/2 overcomes antiestrogen resistance in ER+ breast cancer with FGFR1/2 alterations” [619 1 (2025) 217668 1–13]	158
Corrigendum to “Identification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1” [Can	146
Corrigendum to “Inhibition of Aurora kinases induces apoptosis and autophagy via AURKB/p70S6K/RPL15 axis in human leukemia cells” [Cancer. Lett. (382) 2016-11-28; 382(2):215–230]	146
Valproate and lithium: Old drugs for new pharmacological approaches in brain tumors?	144
METTL3 regulates M6A methylation-modified EBV-pri-miR-BART3-3p to promote NK/T cell lymphoma growth	132
Corrigendum to “The deficiency of ALKBH5 promotes lenvatinib resistance and CD8+ T cell exhaustion via accumulation of the cholesterol metabolite 27HC in hepatocellular carcinoma” [643 10 (2026) 21831	132
Unscheduled polyploidy synergizes with oncogenic mutations to enhance genome instability and tumorigenesis	127
Hormonal and neuronal interactions shaping the brain metastatic microenvironment	123
A novel mismatch repair deficient lung adenocarcinoma model for immunotherapy research	121
TIM3 on natural killer cells regulates antibody-dependent cellular cytotoxicity in HER2-positive gastric cancer	117
ASPH dysregulates cell death and induces chemoresistance in hepatocellular carcinoma	114
Editorial Board	114
Nervous system in colorectal cancer	109
The stromal microenvironment endows pancreatic neuroendocrine tumors with spatially specific invasive and metastatic phenotypes	108
Neutrophil extracellular traps enhance platinum resistance in ovarian cancer via SHP-1 activation	107
Targeting MKK3/c-Myc interaction to overcome osimertinib acquired resistance in EGFR mutant lung cancer	107
A natural compound melatonin enhances the effects of Nimotuzumab via inhibiting EGFR in glioblastoma	105
Regulation of gut microbiota on immune cell ferroptosis: A novel insight for immunotherapy against tumor	103
Cigarette smoke induces FASN-dependent fatty acid metabolic rewiring to drive bladder cancer progression	102

EGFR S442 ectodomain mutation confers cetuximab resistance that can be overcome by ERBB2 blockade with trastuzumab-deruxtecan	98
Spatial multi-omics defines cancer-associated fibroblasts subtype gradients driving metabolic support and immune remodeling in pancreatic ductal adenocarcinoma	96
Novel role of MKRN2 in regulating tumor growth through host microenvironment and macrophage M1 to M2 switch	95
LCAT deficiency promotes hepatocellular carcinoma progression and lenvatinib resistance by promoting triglyceride catabolism and fatty acid oxidation	94
Hypoxia effects on glioblastoma progression through YAP/TAZ pathway regulation	92
Chaperone directed heterobifunctional molecules circumvent KRASG12C inhibitor resistance	92
Increasing membrane polyunsaturated fatty acids sensitizes non-small cell lung cancer to anti-PD-1/PD-L1 immunotherapy	92
CD147-specific chimeric antigen receptor T cells effectively inhibit T cell acute lymphoblastic leukemia	91
FAP upregulates PD-L1 expression in cancer-associated fibroblasts to exacerbate T cells dysfunction and suppress anti-tumor immunity	88
CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy	88
Intratumoral injection of mRNA encoding survivin in combination with STAT3 inhibitor stattic enhances antitumor effects	87
Clinical development of immuno-oncology therapeutics	85
ERBB3 targeting: A promising approach to overcoming cancer therapeutic resistance	83
Fatty acids in cancer chemoresistance	82
Neoantigen discovery and applications in glioblastoma: An immunotherapy perspective	82
M6A-modified lncRNA FAM83H-AS1 promotes colorectal cancer progression through PTBP1	81
Coiled-coil domain-containing 154 promotes colorectal cancer proliferation and metastasis via interacting with minichromosome maintenance complex component 2	80
Manganese mediates nucleoplasm distribution of cGAS to enhance systemic antitumor immunity and drive abscopal effect	80
Dual role of LY96 in shaping the mesenchymal glioblastoma ecosystem through stem cell maintenance and macrophage MES-like reprogramming	79
PROTACs: Novel tools for improving immunotherapy in cancer	79
Tumor-targeted exosomes for delivery of anticancer drugs	78
Evaluation and preservation of fertility in patients with hematologic malignancies	78
Sialic Acids: Sweet modulators fueling cancer cells and domesticating the tumor microenvironment	77
The role of Hippo/YAP1 in cancer-associated fibroblasts: Literature review and future perspectives	77
The E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by targeting CCS for proteasomal degradation to inhibit STAT3 signaling	76
Targeting LINC01607 sensitizes hepatocellular carcinoma to Lenvatinib via suppressing mitophagy	75
The interplay between autophagy and apoptosis: its implication in lung cancer and therapeutics	75
Targeting FOXM1 reshapes antitumor immunity to attenuate small cell lung cancer progression	74
Proteomics and single cell profiling identify keratin driven preexisting immunity influences lung squamous carcinoma neoadjuvant therapy	74
Targeting p53 for immune modulation: Exploring its functions in tumor immunity and inflammation	73
Accelerating the clinical translation of CD70-targeted chimeric antigen receptor-based cell therapies in oncology: A comprehensive clinical investigation panorama analysis based on the Trialtrove data	73
Tuning cellular metabolism for cancer virotherapy	73
CD155 in tumor progression and targeted therapy	70
Osteopontin promotes tumor microenvironment remodeling and therapy resistance	70
Comparable survival outcomes in HLA-Matched and haploidentical hematopoietic stem cell transplantation for severe aplastic anemia patients aged 40–50: A CBMTR Registry-based propensity score matching	69
MDSCs in bone metastasis: Mechanisms and therapeutic potential	69
Selpercatinib mitigates cancer cachexia independent of anti-tumor activity in the HT1080 tumor model	68
An emerging aspect of cancer neuroscience: A literature review on chemotherapy-induced peripheral neuropathy	68
The landscape of malignant transition: Unraveling cancer cell-of-origin and heterogeneous tissue microenvironment	67
Integrated analysis of ascites and plasma extracellular vesicles identifies a miRNA-based diagnostic signature in ovarian cancer	67
KAT7 enhances the proliferation and metastasis of head and neck squamous carcinoma by promoting the acetylation level of LDHA	66