Cancer Letters

Papers
(The TQCC of Cancer Letters is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)
ArticleCitations
Editorial Board347
Ethnic Diversity and Metabolic Variations in Ovarian Cancer Cells: Implications for Personalized Medicine Strategies304
Versatility of Exosomes for Cancer Therapy289
Editorial Board181
An emerging aspect of cancer neuroscience: A literature review on chemotherapy-induced peripheral neuropathy169
Selpercatinib mitigates cancer cachexia independent of anti-tumor activity in the HT1080 tumor model162
Nervous system in colorectal cancer156
Bypassing the Tollway; a novel path to TLR4 independent stemness regulation140
Editorial Board139
Comparable survival outcomes in HLA-Matched and haploidentical hematopoietic stem cell transplantation for severe aplastic anemia patients aged 40–50: A CBMTR Registry-based propensity score matching 137
ASPH dysregulates cell death and induces chemoresistance in hepatocellular carcinoma135
Dual mTORC1/2 inhibitor AZD2014 diminishes myeloid-derived suppressor cells accumulation in ovarian cancer and delays tumor growth121
Targeted inhibition of acidic nucleoplasmic DNA-binding protein 1 enhances radiosensitivity of non-small cell lung cancer121
Targeting p53 for immune modulation: Exploring its functions in tumor immunity and inflammation114
The landscape of malignant transition: Unraveling cancer cell-of-origin and heterogeneous tissue microenvironment111
Chaperone directed heterobifunctional molecules circumvent KRASG12C inhibitor resistance104
CD147-specific chimeric antigen receptor T cells effectively inhibit T cell acute lymphoblastic leukemia104
Corrigendum to “Selective degradation of FGFR1/2 overcomes antiestrogen resistance in ER+ breast cancer with FGFR1/2 alterations” [619 1 (2025) 217668 1–13]102
PI3K inhibitor impairs tumor progression and enhances sensitivity to anlotinib in anlotinib-resistant osteosarcoma101
A natural compound melatonin enhances the effects of Nimotuzumab via inhibiting EGFR in glioblastoma101
Tuning cellular metabolism for cancer virotherapy100
Integrated analysis of ascites and plasma extracellular vesicles identifies a miRNA-based diagnostic signature in ovarian cancer99
The stromal microenvironment endows pancreatic neuroendocrine tumors with spatially specific invasive and metastatic phenotypes96
Hormonal and neuronal interactions shaping the brain metastatic microenvironment96
IBI379, a novel B cell maturation antigen/CD3 bispecific T-cell engager, displays high antitumor efficacy in preclinical models of multiple myeloma96
TIM3 on natural killer cells regulates antibody-dependent cellular cytotoxicity in HER2-positive gastric cancer95
Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in hepatocellular carcinoma cells93
Combination treatment with 17β-estradiol and anti-PD-L1 suppresses MC38 tumor growth by reducing PD-L1 expression and enhancing M1 macrophage population in MC38 colon tumor model93
Understanding the significance of biological clock and its impact on cancer incidence89
Sialic Acids: Sweet modulators fueling cancer cells and domesticating the tumor microenvironment89
Tumor-targeted exosomes for delivery of anticancer drugs88
Intratumoral injection of mRNA encoding survivin in combination with STAT3 inhibitor stattic enhances antitumor effects85
Neoantigen discovery and applications in glioblastoma: An immunotherapy perspective85
CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy83
Coiled-coil domain-containing 154 promotes colorectal cancer proliferation and metastasis via interacting with minichromosome maintenance complex component 283
FAP upregulates PD-L1 expression in cancer-associated fibroblasts to exacerbate T cells dysfunction and suppress anti-tumor immunity80
The E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by targeting CCS for proteasomal degradation to inhibit STAT3 signaling79
Intracellular AGR2 transduces PGE2 stimuli to promote epithelial–mesenchymal transition and metastasis of colorectal cancer78
M6A-modified lncRNA FAM83H-AS1 promotes colorectal cancer progression through PTBP177
METTL3 regulates M6A methylation-modified EBV-pri-miR-BART3-3p to promote NK/T cell lymphoma growth76
Induction of EnR stress by Melatonin enhances the cytotoxic effect of Lapatinib in HER2-positive breast cancer75
Metronomic chemotherapy regimens and targeted therapies in non-Hodgkin lymphoma: The best of two worlds75
LCAT deficiency promotes hepatocellular carcinoma progression and lenvatinib resistance by promoting triglyceride catabolism and fatty acid oxidation75
Sphingosine-1 phosphate receptor 1 (S1PR1) expression maintains stemness of acute myeloid leukemia stem cells72
Regulation of gut microbiota on immune cell ferroptosis: A novel insight for immunotherapy against tumor71
Valproate and lithium: Old drugs for new pharmacological approaches in brain tumors?70
MDSCs in bone metastasis: Mechanisms and therapeutic potential70
ERBB3 targeting: A promising approach to overcoming cancer therapeutic resistance69
Hypoxia effects on glioblastoma progression through YAP/TAZ pathway regulation69
The role of Hippo/YAP1 in cancer-associated fibroblasts: Literature review and future perspectives69
Evaluation and preservation of fertility in patients with hematologic malignancies68
The interplay between autophagy and apoptosis: its implication in lung cancer and therapeutics67
Unscheduled polyploidy synergizes with oncogenic mutations to enhance genome instability and tumorigenesis.67
CD155 in tumor progression and targeted therapy67
Accelerating the clinical translation of CD70-targeted chimeric antigen receptor-based cell therapies in oncology: A comprehensive clinical investigation panorama analysis based on the Trialtrove data67
KAT7 enhances the proliferation and metastasis of head and neck squamous carcinoma by promoting the acetylation level of LDHA64
PROTACs: Novel tools for improving immunotherapy in cancer63
Clinical development of immuno-oncology therapeutics63
Osteopontin promotes tumor microenvironment remodeling and therapy resistance63
Fatty acids in cancer chemoresistance62
Increasing membrane polyunsaturated fatty acids sensitizes non-small cell lung cancer to anti-PD-1/PD-L1 immunotherapy62
Calcium channel TRPV6 promotes breast cancer metastasis by NFATC2IP62
Targeting LINC01607 sensitizes hepatocellular carcinoma to Lenvatinib via suppressing mitophagy62
A high-affinity antibody-drug conjugates Actuximab-MMAE for potent and selective targeting of CEACAM5-Positive tumors61
Letter to the editor on ‘A deep neural network predictor to predict the sensitivity of neoadjuvant chemoradiotherapy in locally advanced rectal cancer’60
ANKZF1 knockdown inhibits glioblastoma progression by promoting intramitochondrial protein aggregation through mitoRQC60
Overexpression of nucleotide metabolic enzyme DUT in hepatocellular carcinoma potentiates a therapeutic opportunity through targeting its dUTPase activity60
Store-operated Ca2+ entry as a key oncogenic Ca2+ signaling driving tumor invasion-metastasis cascade and its translational potential60
Isorhapontigenin (ISO) inhibits EMT through FOXO3A/METTL14/VIMENTIN pathway in bladder cancer cells59
Emerging roles of lysosome homeostasis (repair, lysophagy and biogenesis) in cancer progression and therapy59
MicroRNA-21 deficiency suppresses prostate cancer progression through downregulation of the IRS1-SREBP-1 signaling pathway58
Targeting the genetic landscape of oral potentially malignant disorders has the potential as a preventative strategy in oral cancer58
Tumor-derived miR-378a-3p-containing extracellular vesicles promote osteolysis by activating the Dyrk1a/Nfatc1/Angptl2 axis for bone metastasis58
Plasmacytoid dendritic cells recruited by HIF-1α/eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma58
LKB1 inhibits telomerase activity resulting in cellular senescence through histone lactylation in lung adenocarcinoma57
R-spondin-3 promotes proliferation and invasion of breast cancer cells independently of Wnt signaling57
Glucose restriction induces ROS-AMPK-mediated CTR1 expression and increases cisplatin efficiency in NSCLC56
Sonrotoclax (BGB-11417) synergistically amplifies the radiotherapy-elicited anti-tumor immune response56
Lactylation-boosted polycomb repression of KLF4 elicits glycolysis in retinoblastoma: A positive feedback circuit between histone modifications56
MLCK inhibition induces synthetic lethality in MYC-driven cancer56
The Tn antigen promotes lung tumor growth by fostering immunosuppression and angiogenesis via interaction with Macrophage Galactose-type lectin 2 (MGL2)55
Corrigendum to “Discovery of YH677 as a cancer stemness inhibitor that suppresses triple-negative breast cancer growth and metastasis by regulating the TGFβ signaling pathway” [Canc. Lett. (2023) 216154
Corrigendum to “UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation” [Canc. Lett. 494 (2054
Targeting Amino Acid Dependency for Cancer Treatment52
A feedback circuit comprising EHD1 and 14-3-3ζ sustains β-catenin/c-Myc-mediated aerobic glycolysis and proliferation in non-small cell lung cancer52
The combination of gemcitabine plus an anti-FGFR inhibitor can have a synergistic antitumor effect on FGF-activating cholangiocarcinoma51
Improved antitumor effects elicited by an oncolytic HSV-1 expressing a novel B7H3nb/CD3 BsAb51
Inhibition of T-antigen expression promoting glycogen synthase kinase 3 impairs merkel cell carcinoma cell growth51
MEK-mediated CHPF2 phosphorylation promotes colorectal cancer cell proliferation and metastasis by activating NF-κB signaling50
Advancing neoadjuvant therapy with inetetamab for HER2-Positive breast cancer50
Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma50
FOXF2 expression triggered by endocrine therapy orchestrates therapeutic resistance through reorganization of chromatin architecture in breast cancer50
An effective two-stage NMBzA-induced rat esophageal tumor model revealing that the FAT-Hippo-YAP1 axis drives the progression of ESCC49
Claudin-1 interacts with EPHA2 to promote cancer stemness and chemoresistance in colorectal cancer49
The intratumoral microbiome: Characterization methods and functional impact48
Nanoparticles in the diagnosis and treatment of cancer metastases: Current and future perspectives48
S100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kB/VEGF-D pathway48
Conquering chemoresistance in pancreatic cancer: Exploring novel drug therapies and delivery approaches amidst desmoplasia and hypoxia48
Low-dose metronomic chemotherapy triggers oxidized mtDNA sensing inside tumor cells to potentiate CD8+T anti-tumor immunity47
Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2→CNTF axis to promote progression of brain metastases47
FUT2-dependent fucosylation of LAMP1 promotes the apoptosis of colorectal cancer cells by regulating the autophagy-lysosomal pathway47
Single-cell chemokine receptor profiles delineate the immune contexture of tertiary lymphoid structures in head and neck squamous cell carcinoma47
Identification and characterization of Bufalin as a novel EGFR degrader47
Novel SARS-CoV-2 inhibition properties of the anti-cancer Kang Guan Recipe herbal formula47
PPAR agonists attenuate lenalidomide's anti-myeloma activity in vitro and in vivo47
Functional genomic approaches in acute myeloid leukemia: Insights into disease models and the therapeutic potential of reprogramming46
Human mesenchymal stromal cells maintain their stem cell traits after high-LET particle irradiation – Potential implications for particle radiotherapy and manned space missions46
DAB2IP suppresses tumor malignancy by inhibiting GRP75-driven p53 ubiquitination in colon cancer46
Interplay among extracellular vesicles, cancer stemness and immune regulation in driving hepatocellular carcinoma progression46
Targeting WEE1 kinase as a therapeutic strategy in ATIP3-deficient breast cancers46
Active immunization with a structurally aggregated PD-L1 antigen breaks T and B immune tolerance in non-human primates and exhibits in vivo anti-tumoral effects in immunocompetent mouse tumor models46
Non-muscle myosin II isoforms orchestrate substrate stiffness sensing to promote cancer cell contractility and migration45
WD repeat protein 54-mediator of ErbB2-driven cell motility 1 axis promotes bladder cancer tumorigenesis and metastasis and impairs chemosensitivity45
AI-based radiomic features predict outcomes and the added benefit of chemoimmunotherapy over chemotherapy in extensive stage small cell lung cancer: A multi-institutional study45
Sorbitol dehydrogenase induction of cancer cell necroptosis and macrophage polarization in the HCC microenvironment suppresses tumor progression45
Editorial Board44
Corrigendum to “P-REX1 amplification promotes progression of cutaneous melanomavia the PAK1/P38/MMP-2 pathway” [Cancer Lett. 407 (2017) 66–75]44
Retraction notice to “MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5” [Canc. Lett. 322 (2012) 148–158]44
LINC00978 regulates metabolic rewiring to promote the malignancy of glioblastoma through AKR1B144
Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression44
hnRNPLL regulates MYOF alternative splicing and correlates with early metastasis in pancreatic ductal adenocarcinoma43
The post-chemotherapy changes of tumor physical microenvironment: Targeting extracellular matrix to address chemoresistance43
Editorial Board43
Decoding the potential microbiome modulation strategies from bugs to drugs in pancreatic cancer: Insights from clinical trials43
Develop a Novel Therapy for Pancreatic Cancer43
Editorial Board43
Editorial Board43
Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx42
Long noncoding RNA KB-1460A1.5 inhibits glioma tumorigenesis via miR-130a-3p/TSC1/mTOR/YY1 feedback loop42
Application prospect of circular RNA-based neoantigen vaccine in tumor immunotherapy42
Treatment strategies and molecular mechanism of radiotherapy combined with immunotherapy in colorectal cancer42
Local delivery of optimized nanobodies targeting the PD-1/PD-L1 axis with a self-amplifying RNA viral vector induces potent antitumor responses42
TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer42
Gold nanoparticles and obese adipose tissue microenvironment in cancer treatment42
WEE1 confers resistance to KRASG12C inhibitors in non-small cell lung cancer42
CircUBE3A(2,3,4,5) promotes adenylate-uridylate-rich binding factor 1 nuclear translocation to suppress prostate cancer metastasis41
Mucins as contrast agent targets for fluorescence-guided surgery of pancreatic cancer41
A novel molecular subtyping based on multi-omics analysis for prognosis predicting in colorectal melanoma: A 16-year prospective multicentric study40
Smoking-induced CCNA2 expression promotes lung adenocarcinoma tumorigenesis by boosting AT2/AT2-like cell differentiation40
Shifts in Cancer Funding: An Overview of Terminated Research Grants at the National Cancer Institute40
The feedback loop of AURKA/DDX5/TMEM147-AS1/let-7 drives lipophagy to induce cisplatin resistance in epithelial ovarian cancer40
The safety and efficacy outcomes of Minnelide given alone or in combination with paclitaxel in advanced gastric cancer: A phase I trial40
Mitochondrial fragmentation in liver cancer: Emerging player and promising therapeutic opportunities40
ZC3H13-mediated N6-methyladenosine modification of PHF10 is impaired by fisetin which inhibits the DNA damage response in pancreatic cancer40
Corrigendum to “Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression” [Cancer Lett. 426 (2018) 37–46]40
SENP1-Sirt3 axis promotes cholesterol biosynthesis in tumor-associated macrophages to suppress anti-tumor immunity40
Early detection and intervention of clonal hematopoiesis for preventing hematological malignancies39
Multi-omics analysis unraveling stemness features associated with oncogenic dedifferentiation in 12 cancers39
Exercise in cancer prevention and anticancer therapy: Efficacy, molecular mechanisms and clinical information39
Frontiers in pancreatic cancer on biomarkers, microenvironment, and immunotherapy39
Nanomaterials in crossroad of autophagy control in human cancers: Amplification of cell death mechanisms39
Single-cell RNA-sequencing of human spleens reveals an IDO-1+ tolerogenic dendritic cell subset in pancreatic cancer patients that is absent in normal individuals39
Dysregulation of autophagy in gastric carcinoma: Pathways to tumor progression and resistance to therapy38
Phase separation of EEF1E1 promotes tumor stemness via PTEN/AKT-mediated DNA repair in hepatocellular carcinoma38
Depression in breast cancer patients: Immunopathogenesis and immunotherapy37
Pan-cancer atlas of tumor-resident microbiome, immunity and prognosis37
RNA binding protein RALY activates the cholesterol synthesis pathway through an MTA1 splicing switch in hepatocellular carcinoma37
Radiotherapy-induced tumor physical microenvironment remodeling to overcome immunotherapy resistance37
Long noncoding RNA lnc-LEMGC combines with DNA-PKcs to suppress gastric cancer metastasis37
Suppressive immune microenvironment and CART therapy for glioblastoma: Future prospects and challenges37
Phosphorylation of PBK/TOPK Tyr74 by JAK2 promotes Burkitt lymphoma tumor growth37
Copper in hepatocellular carcinoma: A double-edged sword with therapeutic potentials37
Remodeling of tumor microenvironment by extracellular matrix protein 1a differentially regulates ovarian cancer metastasis37
Tumor-nerve interactions in cancer regulation and progression37
GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2–STAT3 pathway37
REDD1 is a determinant of the sensitivity of renal cell carcinoma cells to autophagy inhibition that can be therapeutically exploited by targeting PIM activity37
Editorial Board36
Editorial Board36
A journey to excellence: Disseminating groundbreaking discoveries in oncology research36
Corrigendum to “Scattered DUSP28 is a novel biomarker responsible for aggravating malignancy via the autocrine and paracrine signaling in metastatic pancreatic cancer” [Cancer Lett. 456 (2019 Aug 1) 136
Super-giant cells: Toward understanding tumor origins on the organismal level36
Circadian disruption in cancer and regulation of cancer stem cells by circadian clock genes: An updated review36
Corrigendum to “Helicobacter pylori upregulates Nanog and Oct4 via Wnt/β-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer” [Canc. Lett. 374 (2016) 292–303]36
Identification of SMARCAL1 as a molecular target for small cell lung cancer treatment36
WITHDRAWN: Proteomic analysis of plasma-derived exosomes identifies biomarkers that distinguish brain and liver metastasis in lung cancer patients36
Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer36
Deciphering the tumor-suppressive role of PSMB9 in melanoma through multi-omics and single-cell transcriptome analyses35
Disparities in mortality risk after diagnosis of hematological malignancies in 185 countries: A global data analysis35
Single-nucleus sequencing unveils heterogeneity in renal cell carcinomas microenvironment: Insights into pathogenic origins and treatment-responsive cellular subgroups35
Corrigendum to “NSUN4 mediated RNA 5-methylcytosine promotes the malignant progression of glioma through improving the CDC42 mRNA stabilization” [Cancer Lett. (2024) 597 217059]35
Letter to the editor regarding “Dual blockade of EGFR and CDK4/6 delays head and neck squamous cell carcinoma progression by inducing metabolic rewiring."35
PI3K PROTAC overcomes the lapatinib resistance in PIK3CA-mutant HER2 positive breast cancer35
Dual targeting PPARα and NPC1L1 metabolic vulnerabilities blocks tumorigenesis35
The mitotic regulator RCC2 promotes glucose metabolism through BACH1-dependent transcriptional upregulation of hexokinase II in glioma35
Effective leukemia-to-granulocyte induction by a cocktail of RUNX1, SPI1 and CEBPE35
Identification of SPP1+ macrophages in promoting cancer stemness via vitronectin and CCL15 signals crosstalk in liver cancer34
Single-cell transcriptomics reveals intratumor heterogeneity and the potential roles of cancer stem cells and myCAFs in colorectal cancer liver metastasis and recurrence34
CRISPR/Cas9 screen reveals that targeting TRIM34 enhances ferroptosis sensitivity and augments immunotherapy efficacy in hepatocellular carcinoma34
Targeted inhibition of CHKα and mTOR in models of pancreatic ductal adenocarcinoma: A novel regimen for metastasis34
Biodistribution and therapeutic efficacy of a gold nanoparticle-based targeted drug delivery system against pancreatic cancer34
CPSF3 regulates alternative polyadenylation of CNIH2 to promote esophageal squamous cell carcinoma progression34
Lipid metabolism reprogramming of CD8+ T cell and therapeutic implications in cancer34
Histone lactylation dynamics: Unlocking the triad of metabolism, epigenetics, and immune regulation in metastatic cascade of pancreatic cancer34
The eIF3a translational control axis in the Wnt/β-catenin signaling pathway and colon tumorigenesis34
Unlocking c-MET: A comprehensive journey into targeted therapies for breast cancer34
Keloids revisited: Current concepts in treatment and differential diagnosis34
High-content drug screening in zebrafish xenografts reveals high efficacy of dual MCL-1/BCL-XL inhibition against Ewing sarcoma34
A novel GRK3-HDAC2 regulatory pathway is a key direct link between neuroendocrine differentiation and angiogenesis in prostate cancer progression34
EDARADD promotes colon cancer progression by suppressing E3 ligase Trim21-mediated ubiquitination and degradation of Snail34
Aging of the progenitor cells that initiate prostate cancer34
SIK1 promotes ferroptosis resistance in pancreatic cancer via HDAC5-STAT6-SLC7A11 axis34
Editorial Board33
SLC7A11/ xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells33
Revisiting the advances and challenges in the clinical applications of extracellular vesicles in cancer33
Editorial Board33
RNA methyltransferase METTL16: From molecular mechanisms to therapeutic prospects in cancers33
Editorial Board33
Targeting tumor-intrinsic SLC16A3 to enhance anti-PD-1 efficacy via tumor immune microenvironment reprogramming33
Editorial Board33
Significance of longitudinal Epstein–Barr virus DNA combined with multipoint tumor response for dynamic risk stratification and treatment adaptation in nasopharyngeal carcinoma32
TFAP2C-DDR1 axis regulates resistance to CDK4/6 inhibitor in breast cancer32
PPDPF promotes esophageal squamous cell carcinoma progression by blocking PCCA binding to PCCB and inhibiting methionine catabolism32
Loss of ASAP1 in the MMTV-PyMT model of luminal breast cancer activates AKT, accelerates tumorigenesis, and promotes metastasis32
IgSF protein EWI2 is a tumor suppressor32
Cancer stem cells and tumor-associated macrophages: Interactions and therapeutic opportunities32
ITPR1-AS1 promotes small cell lung cancer metastasis by facilitating P21 splicing and stabilizing DDX3X to activate the cRaf-MEK-ERK cascade32
Harnessing genetic interactions for prediction of immune checkpoint inhibitors response signature in cancer cells32
Editorial Board32
GALNT3 suppresses lung cancer by inhibiting myeloid-derived suppressor cell infiltration and angiogenesis in a TNFR and c-MET pathway-dependent manner32
Multi-functional extracellular vesicles: Potentials in cancer immunotherapy32
How to design next-generation of antibody-drug conjugates for cancer treatment: Lessons from unsuccessful clinical trials31
The new era of pancreatic cancer treatment: Application of nanotechnology breaking through bottlenecks31
Corrigendum to “Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance” [Cancer Lett. (2018) 412 243–255]31
Evolution and contemporary role of metronomic chemotherapy in the treatment of neuroblastoma31
Confusion about the article: Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ31
The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway31
Mutant IDH1 promotes phagocytic function of microglia/macrophages in gliomas by downregulating ICAM131
The nuclear condensates of ESE3/EHF induce cellular senescence without the associated inflammatory secretory phenotype in pancreatic ductal adenocarcinoma31
Statin in combination with cisplatin makes favorable tumor-immune microenvironment for immunotherapy of head and neck squamous cell carcinoma31
Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice31
Targeting the molecular chaperone CCT2 inhibits GBM progression by influencing KRAS stability31
CHEK2 deficiency increase the response to PD-1 inhibitors by affecting the tumor immune microenvironment31
circCCNY enhances lenvatinib sensitivity and suppresses immune evasion in hepatocellular carcinoma by serving as a scaffold for SMURF1 mediated HSP60 degradation31
The intersections between neuroscience and medulloblastoma31
Cancer-associated fibroblast-like fibroblasts in vocal fold leukoplakia suppress CD8+T cell functions by inducing IL-6 autocrine loop and interacting with Th17 cells31
Proteolysis of a histone acetyl reader, ATAD2, induces chemoresistance of cancer cells under severe hypoxia by inhibiting cell cycle progression in S phase31
Cancer-associated fibroblasts: A key target to snatch victory from defeat in therapy resistance associated with the pancreatic cancer stroma30
Magnolin targeting of the JNK/Sp1/MMP15 signaling axis suppresses cervical cancer microenvironment and metastasis via microbiota modulation30
Extracellular vesicle biomarkers redefine prostate cancer radiotherapy30
Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies30
A novel role of TGFBI in macrophage polarization and macrophage-induced pancreatic cancer growth and therapeutic resistance30
A novel microenvironment regulated system CAR-T (MRS.CAR-T) for immunotherapeutic treatment of esophageal squamous carcinoma30
The transformation of cancer-associated fibroblasts: Current perspectives on the role of TGF-β in CAF mediated tumor progression and therapeutic resistance30
Deciphering the immune modulation through deep transcriptomic profiling and therapeutic implications of DNA damage repair pattern in hepatocellular carcinoma30
IDO1/TDO dual inhibitor RY103 targets Kyn-AhR pathway and exhibits preclinical efficacy on pancreatic cancer30
Inflammatory cytokine-regulated LNCPTCTS suppresses thyroid cancer progression via enhancing Snail nuclear export30
Tumor-derived extracellular vesicles induce invalid cytokine release and exhaustion of CD19 CAR-T Cells30
AXL signal mediates adaptive resistance to KRAS G12C inhibitors in KRAS G12C-mutant tumor cells30
HMGB1 in the interplay between autophagy and apoptosis in cancer30
A foundation model with weak experiential guidance in detecting muscle invasive bladder cancer on MRI30
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