Pain

Article	Citations
Impact of spinal cord stimulation on sick leave and disability pension in patients with chronic neuropathic pain: a real-world evidence study in Sweden	508
Randomized controlled trial of intrathecal oxytocin on speed of recovery after hip arthroplasty	298
Mediators of the association between childhood trauma and pain sensitivity in adulthood: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network analysis	144
A within-subject, double-blind, placebo-controlled randomized evaluation of the combined effects of cannabidiol and hydromorphone in a human laboratory pain model	113
Nerve pathology and neuropathic pain after whiplash injury: a systematic review and meta-analysis	97
Validation of the pediatric version of the Graded Chronic Pain Scale Revised in school-aged children and adolescents	83
What is known and what is still unknown within chronic musculoskeletal pain? A systematic evidence and gap map	77
Combination pharmacotherapy for the treatment of neuropathic pain in adults: systematic review and meta-analysis	71
Reply to Venda Nova et al.	65
Autoantibodies in patients with fibromyalgia syndrome	61
Perioperative oxidative stress predicts subsequent pain-related outcomes in the 6 months after total knee arthroplasty	58
Association between prescribed opioid dose and risk of motor vehicle crashes	58
Maddalena Opioid Switching Score in patients with cancer pain	58
Reply to Gholamrezaei and Ashton-James	57
Visually evoked pain and its extinction using virtual reality in a patient with complex regional pain syndrome type II	57
Improving the art and science of communication in people living with chronic pain	56
Reply to Riddle	55
Beyond social support: in search of psychosocial predictors of chronic postsurgical pain	55
Delphi study to explore a new diagnosis for “ineffective” long-term opioid therapy for chronic pain	53
Encoding of inflammatory hyperalgesia in mouse spinal cord	51
Reply to Currie et al.	49
Mismatched opioid prescription in patients discharged after neurological surgeries: a retrospective cohort study	49
External validation and updating of prognostic prediction models for nonrecovery among older adults seeking primary care for back pain	47
UnCRMPing Nav1.7 to treat trigeminal neuropathic pain	47
Placebo analgesia and nocebo hyperalgesia in patients with Alzheimer disease and healthy participants	46

Practical nonpharmacologic pain interventions for hospitalized cancer patients	45
Commentary on: A systematic review of self and observer assessment of pain and related functioning in youth with brain-based developmental disabilities	42
The prevalence of persistent post-traumatic headache in adult civilian traumatic brain injury: a systematic review and meta-analysis on the past 14 years	42
Neurobiology and long-term impact of bladder-filling pain in humans: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) research network study	42
The role of evolving concepts and new technologies and approaches in advancing pain research, management, and education since the establishment of the International Association for the Study of Pain	41
Future perspectives: the next fifty years of the International Association for the Study of Pain	39
Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations	39
Fifty years of pain research and clinical advances: highlights and key trends	39
Pro-opiomelanocortin neurons in the nucleus of the solitary tract mediate endorphinergic endogenous analgesia in mice	38
Cognitive decline over time in patients with chronic pain and headache: how can different outcomes be explained?	38
Diagnosis of neuropathic pain in polyneuropathy: should screening questionnaires be thrown out?	38
Distinct and sex-specific expression of mu opioid receptors in anterior cingulate and somatosensory S1 cortical areas	36
Autoantibodies from patients with complex regional pain syndrome induce pro-inflammatory effects and functional disturbances on endothelial cells in vitro	36
A rose by another name? Characteristics that distinguish headache secondary to temporomandibular disorder from headache that is comorbid with temporomandibular disorder	35
Reply to dos Santos Ferreira and Velly	35
A synthesis of meta-analyses of mindfulness-based interventions in pain	34
Effects of opioid rotation to buprenorphine/naloxone on pain, pain thresholds, pain tolerance, and quality of life in patients with chronic pain and opioid use disorder	34
Reply to Yang and Lu	33
The dynamics of pain avoidance: the exploration–exploitation dilemma	32
The relationship between traumatic exposure and pain perception in children: the moderating role of posttraumatic symptoms	32
Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice	32
On the adverse effects of gabapentinoids	32
Longitudinal examination of associations with the onset of pediatric chronic pain at different pain locations	31
Data-driven identification of distinct pain drawing patterns and their association with clinical and psychological factors: a study of 21,123 patients with spinal pain	31
Tools for assessing labour pain: a comprehensive review of research literature	30
Painful distortions: people with painful knee osteoarthritis have biased visuospatial perception of the environment	30
Long-term opioid therapy dose patterns in United States patients	30
Emergence of nociceptive functionality and opioid signaling in human induced pluripotent stem cell–derived sensory neurons	30
Rethinking clinically significant pain: a marker of recovery rather than a warning of injury	30
Under the insula: a commentary on “electrostimulation of the white matter of the posterior insula and medial operculum: perception of vibrations, heat, and pain”	29
Brain-predicted age difference estimated using DeepBrainNet is significantly associated with pain and function—a multi-institutional and multiscanner study	29
Deoxy-sphingolipids, oxidative stress, and vitamin C correlate with qualitative and quantitative patterns of small fiber dysfunction and degeneration	29
Benign or painful? The interpretation of pain and fear of progression in rheumatoid arthritis	29
Vaporized cannabis extract–induced antinociception in male vs female rats with persistent inflammatory pain	29
Adolescent pain: appraisal of the construct and trajectory prediction-by-symptom between age 12 and 17 years in a Canadian twin birth cohort	29
Sex differences in visceral sensitivity and brain activity in a rat model of comorbid pain: a longitudinal study	29
The social nature of human pain	28
Reply to Huang and Chen	27
Strengthening the pain care ecosystem to support equitable, person-centered, high-value musculoskeletal pain care	27
Sex differences in chromatin structure within the dorsal root ganglion	27
Individual differences in conditioned pain modulation are associated with functional connectivity within the descending antinociceptive pathway	27
Randomized controlled trials of pain treatment: essential research tools, a framework for clinical care	27
Promoting multidisciplinary pain management in low- and middle-income countries—challenges and achievements	26
Stratified health care for low back pain using the STarT Back approach: holy grail or doomed to fail?	26
Gray matter volume of limbic brain structures during the development of chronic back pain: a longitudinal cohort study	25
Pain catastrophizing and pain anxiety mediate changes in physical function in a mind–body intervention for adults with traumatic orthopedic injuries	25
Microbiome contributions to pain: a review of the preclinical literature	25
Noninvasive targeted modulation of pain circuits with focused ultrasonic waves: Erratum	25
Advanced neuroimaging of the trigeminal nerve and the whole brain in trigeminal neuralgia: a systematic review	25
What has brain diffusion magnetic resonance imaging taught us about chronic primary pain: a narrative review	25

High-frequency electrical stimulation increases cortical excitability and mechanical sensitivity in a chronic large animal model	25
Species-specific differences and the role of Nav1.9 in pain pathophysiology	25
Neuroanatomical evidence and a mouse calcitonin gene–related peptide model in line with human functional magnetic resonance imaging data support the involvement of peptidergic Edinger–Westphal nucleus	24
The unmet mental health needs of U.S. adults living with chronic pain	24
Chronic pain in patients with inflammatory bowel disease	24
Reductions in kinesiophobia and distress after pain neuroscience education and exercise lead to favourable outcomes: a secondary mediation analysis of a randomized controlled trial in primary care	24
Effect of prolonged experimental neck pain on exercise-induced hypoalgesia	24
Membrane potential instabilities in sensory neurons: mechanisms and pathophysiological relevance	24
Targeted muscle reinnervation prevents and reverses rat pain behaviors after nerve transection	24
The relationship between sustained hamstring pain and reorganisation of somatosensory representations: a randomised, controlled study	24
Reply to Quintner	24
Eveningness intensifies the association between musculoskeletal pain and health-related quality of life: a Northern Finland Birth Cohort Study 1966	24
NaViGating arthritis pain	23
Investigating neuroepigenetic alterations in chronic low back pain with positron emission tomography	23
Probing white matter microstructure in youth with chronic pain and its relation to catastrophizing using neurite orientation dispersion and density imaging	23
Refining lidocaine studies for inflammatory arthritis	23
Peripherally restricted cannabinoid and mu-opioid receptor agonists synergistically attenuate neuropathic mechanical hypersensitivity in mice	23
Pain is common after sexual assault and posttraumatic arousal/reactivity symptoms mediate the development of new or worsening persistent pain	23
Reply to Torta and Meyers	23
Validation of ICD-11 chronic pain severity specifiers for children and adolescents: an important step forward	22
Pain after cancer: navigating the complexities and embracing psychological insights	22
Spontaneous pain dynamics characterized by stochasticity in neural recordings of awake humans with chronic pain	22
Impact of rescue medication in placebo-controlled trials of pharmacotherapy for neuropathic pain and low back pain	22
International Classification of Diseases-11 chronic pain severity specifiers for children and adolescents: a validation study	22
Mortality after concurrent treatment with gabapentin and opioids in older adults with spine diagnoses	22
Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice	21
Exploring sex differences in alpha brain activity as a potential neuromarker associated with neuropathic pain	21
Disruption of working memory and contralateral delay activity by nociceptive stimuli is modulated by task demands	21
Effects of combined chemotherapy and anti-programmed cell death protein 1 treatment on peripheral neuropathy and neuroinflammation in mice	21
Differential pain perception among females with or without nonspecific chronic low back pain and comorbid insomnia: a quantitative sensory testing analysis	21
Looking beyond the obvious: the importance of outcomes and outcomes measures in trigeminal neuralgia	21
Reply to Blatt	21
Mechanisms of chronic pain in inflammatory rheumatism: the role of descending modulation	21
Whiplash injuries associated with experienced pain and disability can be visualized with [11C]-D-deprenyl positron emission tomography and computed tomography	21
A prospective long-term follow-up of dorsal root ganglion stimulation for the management of chronic intractable pain	21
Associations between patient-reported functional disability and measures of physical ability in juvenile fibromyalgia	20
Long-term opioid therapy unsettles us both coming and going	20
Nitroxidative stress in pain and opioid-induced adverse effects: therapeutic opportunities	20
Automated detection of squint as a sensitive assay of sex-dependent calcitonin gene–related peptide and amylin-induced pain in mice	20
Vaso-occlusive crisis pain intensity, frequency, and duration: which best correlates with health-related quality of life in adolescents and adults with sickle cell disease?	20
Information is power: a qualitative study exploring the lived experiences of patients with degenerative cervical radiculopathy	20
Education can reassure people with rotator cuff–related shoulder pain: a 3-arm, randomised, online experiment	20
Longitudinal study of early adaptation to the coronavirus disease pandemic among youth with chronic pain and their parents: effects of direct exposures and economic stress	19
TRPM3-mediated dynamic mitochondrial activity in nerve growth factor–induced latent sensitization of chronic low back pain	19
Chronic pain is specifically associated with updating working memory: a longitudinal twin study	19
Relationship between gait complexity and pain attention in chronic low back pain	19
Anoctamin 1/TMEM16A in pruritoceptors is essential for Mas-related G protein receptor–dependent itch	19
Extended reality used in the treatment of phantom limb pain: a multicenter, double-blind, randomized controlled trial	19
Rare variant analyses in large-scale cohorts identified SLC13A1 associated with chronic pain	19
Neuropathic pain and neurocognitive functioning in children treated for acute lymphoblastic leukemia	19
Spared nerve injury decreases motivation in long-access homecage-based operant tasks in mice	18
Sex differences in facial expressions of pain: results from a combined sample	18
Behavioral characterization of G-protein-coupled receptor 160 knockout mice	18
Induction of cluster headache after opening of adenosine triphosphate-sensitive potassium channels: a randomized clinical trial	18
Innovative cognitive behavioral therapies for irritable bowel syndrome: processes, predictors, platforms, and outcomes	18
In memoriam: Joel D. Greenspan 1952 to 2021	18
Gut microbiota dysbiosis alters chronic pain behaviors in a humanized transgenic mouse model of sickle cell disease	18
Adolescent ethanol exposure promotes mechanical allodynia and alters dopamine transmission in the nucleus accumbens shell	18
Time-varying phase synchronization of resting-state functional magnetic resonance imaging reveals a shift toward self-referential processes during sustained pain	18
Pharmacologically enabling the degradation of NaV1.8 channels to reduce neuropathic pain	17
Statistical modeling of acute and chronic pain patient-reported outcomes obtained from ecological momentary assessment	17
Biodegradable nanoparticles targeting circulating immune cells reduce central and peripheral sensitization to alleviate neuropathic pain following spinal cord injury	17
Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project)	17
Towards harmonizing the concepts and definitions of pain in the World Health Organization's Family of International Classifications	17
Dynamics of brain function in patients with chronic pain assessed by microstate analysis of resting-state electroencephalography	17
Intrinsic and synaptic properties of adult mouse spinoperiaqueductal gray neurons and the influence of neonatal tissue damage	17
Pain management in older adults: facts to consider	17
Treatment effect modifiers for individuals with acute low back pain: secondary analysis of the TARGET trial	17
Nociplastic pain: helping to explain disconnect between pain and pathology	17
On the importance of baseline pain intensity and measurement methods	17
Immigration background as a risk factor of chronic pain and high-impact chronic pain in children and adolescents living in Spain: differences as a function of age	16
Regression to the mean, heteroscedasticity, and prognostic imbalance in randomized controlled trials: a call for graphical methods	16
A peripheral CB2 cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy: evidence from a CB2 reporter mouse	16
Description and initial validation of a novel measure of pain intensity: the Numeric Rating Scale of Underlying Pain without concurrent Analgesic use	16
Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain	16
A global look at RNA splicing in human dorsal root ganglion: ex uno plures	16
Independent effects of transcranial direct current stimulation and social influence on pain	16
Discrimination as one of the social plights facing people with pain	16
Peripheral or central origin of chronic pain? Mu!	16
Reply to Zhao et al.	16

Tyrosine kinase type A–specific signalling pathways are critical for mechanical allodynia development and bone alterations in a mouse model of rheumatoid arthritis	16
Recent developments and challenges in positron emission tomography imaging of gliosis in chronic neuropathic pain	16
Protein arginine methyltransferase 7 modulates neuronal excitability by interacting with NaV1.9	16
Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons	16
Psychiatric disorders, personality traits, and childhood traumatic events predicting incidence and persistence of chronic pain: results from the CoLaus|PsyCoLaus study	15
Characteristics of retracted publications related to pain research: a systematic review	15
Widespread hyperexcitability of nociceptor somata outlasts enhanced avoidance behavior after incision injury	15
Reply to Huang and Lu	15
Adenosine causes short-lasting vasodilation and headache but not migraine attacks in migraine patients: a randomized clinical trial	15
Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study	15
Preparing the brain for pain: new insights and potential biomarkers	15
Neuropilin-1 is essential for vascular endothelial growth factor A–mediated increase of sensory neuron activity and development of pain-like behaviors	15
Biomarkers of stress as mind–body intervention outcomes for chronic pain: an evaluation of constructs and accepted measurement	15
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients	15
Novel proresolving lipid mediator mimetic 3-oxa-PD1n-3 docosapentaenoic acid reduces acute and chronic itch by modulating excitatory and inhibitory synaptic transmission and astroglial secretion of li	15
Neuronal basis for pain-like and anxiety-like behaviors in the central nucleus of the amygdala	15
Spatial illusion of pain: the influence of nociception on body ownership	15
Genome-wide association study of pain sensitivity assessed by questionnaire and the cold pressor test	14
Deep learning modelling of structural brain MRI in chronic head and neck pain after mild TBI	14
Patient outcomes after opioid dose reduction among patients with chronic opioid therapy	14
Altered pain sensitivity in 5×familial Alzheimer disease mice is associated with dendritic spine loss in anterior cingulate cortex pyramidal neurons	14
Bruxism, temporomandibular disorders, and headache: a narrative review of correlations and causalities	14
Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood: The HUNT Study	14
Cortical function and sensorimotor plasticity are prognostic factors associated with future low back pain after an acute episode: the Understanding persistent Pain Where it ResiDes prospective cohort	14
Effect of intraoperative methadone vs other opioids on postoperative outcomes: a meta-analysis of randomized controlled studies	14
Genetic and functional evidence for gp130/IL6ST-induced transient receptor potential ankyrin 1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain	14
Updated recommendations on measures for clinical trials in pediatric chronic pain: a multiphase approach from the Core Outcomes in Pediatric Persistent Pain (Core-OPPP) Workgroup	14
Partnering with patients in clinical trials of pain treatments: a narrative review	14
Persistent opioid use after hospital admission due to trauma: a population-based cohort study	14
Activation of GABAergic neurons in the dorsal raphe nucleus alleviates hyperalgesia induced by ovarian hormone withdrawal	14
Unrelieved pain and risk of opioid use disorder or overdose in older adults prescribed opioids	14
Diversity of inhibitory and excitatory parvalbumin interneuron circuits in the dorsal horn	14
Trigeminal neuralgia and its comorbidities: a nationwide disease trajectory study	14
Pediatric chronic pain grading: a revised classification of the severity of pediatric chronic pain	14
Astrocytes in the rostral ventromedial medulla mediate the analgesic effect of electroacupuncture in a rodent model of chemotherapy-induced peripheral neuropathic pain	14
Fibromyalgia patients with elevated levels of anti–satellite glia cell immunoglobulin G antibodies present with more severe symptoms	13
Targeting intrinsically disordered regions facilitates discovery of calcium channels 3.2 inhibitory peptides for adeno-associated virus–mediated peripheral analgesia	13
Opioid deprescribing in patients with chronic noncancer pain: a systematic review of international guidelines	13
Microglia senescence is related to neuropathic pain–associated comorbidities in the spared nerve injury model	13
At my own pace, space, and place: a systematic review of qualitative studies of enablers and barriers to telehealth interventions for people with chronic pain	13
Mitochondrial calcium uniporter deletion prevents painful diabetic neuropathy by restoring mitochondrial morphology and dynamics	13
Reconsidering Fordyce's classic article, “Pain and suffering: what is the unit?” to help make our model of chronic pain truly biopsychosocial	13
Was it “conditioned” or “suggested” pain? Reply to S. Kang et al.	13
Intensive interdisciplinary pain treatment for children and adolescents with chronic noncancer pain: a preregistered systematic review and individual patient data meta-analysis	13
Development and evaluation of the patient-reported outcomes measurement information system (PROMIS) pediatric pain quality item bank and short form	13
Activation of TGR5 in the injured nerve site according to a prevention protocol mitigates partial sciatic nerve ligation–induced neuropathic pain by alleviating neuroinflammation	13
Transcranial direct current stimulation of 3 cortical targets is no more effective than placebo as treatment for fibromyalgia: a double-blind sham-controlled clinical trial	13
Chronic pain conditions and use of analgesics among nursing home patients with dementia	13
Differential expression of a brain aging biomarker across discrete chronic pain disorders	13
In search of conditioned pain: an experimental analysis	13
Selective androgen receptor modulator microparticle formulation reverses muscle hyperalgesia in a mouse model of widespread muscle pain	13
Intersectional identity approach to chronic pain disparities using latent class analysis	13
Proinflammatory cytokines and their receptors as druggable targets to alleviate pathological pain	13
The prevalence of chronic pain in young adults: a systematic review and meta-analysis	13
Chronic nociplastic pain affecting the musculoskeletal system: clinical criteria and grading system	12
Peoples' beliefs about their chronic hip pain and its care: a systematic review of qualitative studies. “I'm just getting old and breaking down”	12
Reply to Beaulieu	12
The value of the International Association for the Study of Pain to career development: perspectives of trainee and early career members	12
Taxonomy and pain clinic patients	12
Paradoxical heat sensation as a manifestation of thermal hypesthesia: a study of 1090 patients with lesions of the somatosensory system	12
Benefit–risk assessment and reporting in clinical trials of chronic pain treatments: IMMPACT recommendations	12
Barriers and enablers to exercise adherence in people with nonspecific chronic low back pain: a systematic review of qualitative evidence	12
Signatures of chronic pain in multiple sclerosis: a machine learning approach to investigate trigeminal neuralgia	12
Subcortical brain anatomy as a potential biomarker of persistent pain after total knee replacement in osteoarthritis	12
Heart rate variability is not suitable as a surrogate marker for pain intensity in patients with chronic pain	12
Reliability of quantitative sensory testing in the assessment of somatosensory function after high-frequency stimulation–induced sensitisation of central nociceptive pathways	12
Preventing a prescription opioid epidemic in Switzerland	12
Morphine-induced osteolysis and hypersensitivity is mediated through toll-like receptor-4 in a murine model of metastatic breast cancer	12
Habituation to pain: self-report, electroencephalography, and functional magnetic resonance imaging in healthy individuals. A scoping review and future recommendations	12
Neurofilament light chain as a biomarker of axonal damage in sensory neurons and paclitaxel-induced peripheral neuropathy in patients with ovarian cancer	12
Neuronal–immune axis alters pain and sensory afferent damage during dental pulp injury	12
Message from the president of the International Association for the Study of Pain	12
Reply to Russo et al.	12
Association between physiotherapy utilization and medical healthcare utilization and costs in adults with back pain from Ontario, Canada: a population-based cohort study	12
Sex differences in pain expressed by patients across diverse disease states: individual patient data meta-analysis of 33,957 participants in 10 randomized controlled trials	12
Sex effects in the interaction of acute stress and pain perception	12
The T-type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuli	11
Call to focus on digital health technologies in hospitalized children's pain care: clinician experts' qualitative insights on optimizing electronic medical records to improve care	11
Machine learning-based identification of determinants for rehabilitation success and future healthcare use prevention in patients with high-grade, chronic, nonspecific low back pain: an individual dat	11
Sex differences in medical cannabis-related adverse effects? Do not forget the context!	11
Migraine chronification is associated with beta-band connectivity within the pain-related cortical regions: a magnetoencephalographic study	11
Achieving reliable pain change scores for individuals in the postoperative phase: carefully choose sampling density, test length, and administration mode	11
Reply to Mickle and Sibille	11
The impact of the COVID-19 pandemic on pain and psychological functioning in young adults with chronic pain	11
Brain predictors of multisite pain onset in children	11
Reply to dos Santos Ferreira and Velly	11
Evolution of somatosensory processing signs after nociceptive targeted surgery in patients with musculoskeletal disorders: a systematic review	11
Diagnostic accuracy of the Pain (P), Enjoyment (E), and General activity (G) scale, a three-item questionnaire, for grading the impact of orofacial pain-related dysfunction	11
Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice: erratum	11
Narrative bias (“spin”) is common in randomised trials and systematic reviews of cannabinoids for pain	11
Cortical mechanisms of visual hypersensitivity in women at risk for chronic pelvic pain	11
Pain memory in children: a systematic review and meta-analysis with a meta-regression	11
The burden of preoperative fear-avoidance beliefs in workers after thoracic and lumbar spine surgery: a 2-year follow-up study	11
Job stress and chronic and widespread musculoskeletal pain: a cross-sectional analysis from the Brazilian Longitudinal Study of Adult Health Musculoskeletal	11
Functional significance of macrophage-derived exosomes in inflammation and pain: erratum	11