Pain

Article	Citations
Table of Contents	238
Showcasing scientific discovery in PAIN: an opportunity for authors	178
The future of pain research: neuromodulation and surgery	111
Reply to dos Santos Ferreira and Velly	108
Future perspectives: the next fifty years of the International Association for the Study of Pain	102
Validation of ICD-11 chronic pain severity specifiers for children and adolescents: an important step forward	90
Painful distortions: people with painful knee osteoarthritis have biased visuospatial perception of the environment	78
Diagnostic accuracy of quantitative sensory testing for detecting small fiber impairment in polyneuropathy and diagnosing small fiber neuropathy	73
Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project)	69
On the adverse effects of gabapentinoids	67
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients	66
Chronic pain is specifically associated with updating working memory: a longitudinal twin study	62
Improving the art and science of communication in people living with chronic pain	56
White matter microstructural associations with pain experiences in a large community sample of youth	56
Reply to Quintner	56
Vaso-occlusive crisis pain intensity, frequency, and duration: which best correlates with health-related quality of life in adolescents and adults with sickle cell disease?	51
Data-driven identification of distinct pain drawing patterns and their association with clinical and psychological factors: a study of 21,123 patients with spinal pain	50
Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood: The HUNT Study	50
Innovative cognitive behavioral therapies for irritable bowel syndrome: processes, predictors, platforms, and outcomes	49
Chemokines as targets to treat chronic postoperative pain	48
Widespread hyperexcitability of nociceptor somata outlasts enhanced avoidance behavior after incision injury	48
Intrinsic and synaptic properties of adult mouse spinoperiaqueductal gray neurons and the influence of neonatal tissue damage	48
The impact of opioid withdrawal symptoms on pain outcomes in enriched enrollment randomized withdrawal trials: a mediation meta-analysis of trials submitted to the US Food and Drug Administration	45
C–C motif chemokine ligand 12 (CCL12) is a critical chemokine driving postoperative pain	45
Sex differences in visceral sensitivity and brain activity in a rat model of comorbid pain: a longitudinal study	43

Reply to Alcántara Montero: Towards a unified paradigm: chronic pain and functional somatic disorders	41
Pediatric chronic pain grading: a revised classification of the severity of pediatric chronic pain	41
The contribution of baseline circulating endocannabinoids to individual differences in human pain sensitivity: a quantitative sensory testing study	39
Sex differences in facial expressions of pain: results from a combined sample	39
Statistical modeling of acute and chronic pain patient-reported outcomes obtained from ecological momentary assessment	38
Subjective salience ratings are a reliable proxy for physiological measures of arousal	38
Adenosine causes short-lasting vasodilation and headache but not migraine attacks in migraine patients: a randomized clinical trial	37
Episodic pain in Fabry disease is mediated by a heat shock protein-transient receptor potential cation channel A1 axis	37
The social nature of human pain	37
Benign or painful? The interpretation of pain and fear of progression in rheumatoid arthritis	37
Selective targeting of voltage-gated sodium channels to achieve analgesia: current status and future directions	37
Association between prescribed opioid dose and risk of motor vehicle crashes	36
Neuropilin-1 is essential for vascular endothelial growth factor A–mediated increase of sensory neuron activity and development of pain-like behaviors	34
Description and initial validation of a novel measure of pain intensity: the Numeric Rating Scale of Underlying Pain without concurrent Analgesic use	34
Translational control by general control nonderepressible 2 kinase regulates methylglyoxal-induced pain in mice	33
Autoantibodies in patients with fibromyalgia syndrome	33
Unrelieved pain and risk of opioid use disorder or overdose in older adults prescribed opioids	33
Sex differences in pain expressed by patients across diverse disease states: individual patient data meta-analysis of 33,957 participants in 10 randomized controlled trials	32
Gut microbiota dysbiosis alters chronic pain behaviors in a humanized transgenic mouse model of sickle cell disease	32
Alzheimer disease may compromise patients' ability for expectancy-based pain modulation. Now what?	32
How the next 50 years of positron emission tomography can transform our understanding of chronic pain	31
Rejuvenation alleviates prolonged postsurgical pain in aging mice by mitigating inflammaging	31
Region-specific changes in brain glutamate and gamma-aminobutyric acid across the migraine attack in children and adolescents	31
Gaining a new footing on molecular mechanisms of neuropathic pain in patients	31
Reply to Andrassy and Mukhdomi	30
TRESK background potassium channel regulates MrgprA3+ pruriceptor excitability, acute and chronic itch	30
Thermal grill–induced pain: further evidence for its pathophysiological and clinical relevance	30
Effects of transcranial ultrasound stimulation of primary somatosensory cortex and ventral posterolateral nucleus of the thalamus on acute pain perception	30
Formation of perineuronal nets within a thalamocortical circuit shapes mechanical and thermal pain thresholds in mice with neuropathic pain	29
Opioid dose and pain effects of an online pain self-management program to augment usual care in adults with chronic pain: a multisite randomized clinical trial	29
[11C]-PBR28 positron emission tomography signal as an imaging marker of joint inflammation in knee osteoarthritis	29
Towards a tool to discriminate between pain mechanistic descriptors: expert ranking of clinical features and allocation of weights using a forced choice paradigm	29
Forward and reverse engineering the pain system: from computational neuroscience to neuro-engineering	28
Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus	28
Leveraging technologies to upskill primary care providers in person-centred pain care	28
Increasing risk of cannabis use disorder among U.S. veterans with chronic pain: 2005-2019	27
Editorial Board	27
Effect modifiers of virtual reality in pain management: a systematic review and meta-regression analysis	26
Unintended prolonged opioid use: a prospective case–control study	26
Multisite chronic pain as a causal risk factor for coronary artery disease: findings from Mendelian randomization	26
Who develops chronic pain after an acute lower limb injury? A longitudinal study of children and adolescents	26
The impact of chronic pain on brain gene expression	25
Prevalence and correlates of “undiagnosed pain”: evidence from the US national Medical Expenditure Panel Survey	25
Association between physiotherapy utilization and medical healthcare utilization and costs in adults with back pain from Ontario, Canada: a population-based cohort study	25
Application of neurite orientation dispersion and density imaging in characterizing brain microstructural changes in classical trigeminal neuralgia and a comparison between the left and right sides	25
Peripheral and central neurobiological effects of botulinum toxin A (BoNT/A) in neuropathic pain: a systematic review	25
Social support and the association between post-traumatic stress disorder and risk for long-term prescription opioid use	25
Reliability of quantitative sensory testing in the assessment of somatosensory function after high-frequency stimulation–induced sensitisation of central nociceptive pathways	24
Dyspareunia: a novel clinical approach for diagnosis based on pain mechanisms	24
Prevalence and characterization of pediatric-onset spinal cord injury pain as reported by youth: an observational and case control association study with TRPA1 gene single nucleotide polymorphisms	24

Astrocytogenic bidirectional plasticity at spinal nociceptive synapses regulates acute nociceptive processing	24
Educational needs and preferences of adult patients with acute pain: a mixed-methods systematic review	23
Paradoxical heat sensation as a manifestation of thermal hypesthesia: a study of 1090 patients with lesions of the somatosensory system: erratum	23
Progression trajectories of chronic overlapping pain conditions unveiled across two large clinical data warehouses	23
The biopsychosocial model of pain 40 years on: time for a reappraisal?	23
Transcranial direct current stimulation of primary motor cortex reduces thermal pain	23
Efficacy and safety of eliapixant in diabetic neuropathic pain and prediction of placebo responders with an exploratory novel algorithm: results from the randomized controlled phase 2a PUCCINI study	23
Social disparities in pain	23
Reply to Chang, Gau, and Jhang	23
Hypermobility and chronic pain in adolescents: diverging functional and neural profiles without sensory differences	23
Adjunctive virtual reality pain relief after traumatic injury: a proof-of-concept within-person randomized trial	23
Reply to Rattanapitoon et al.	23
Incidence of chronic pelvic pain after childbirth and its causal association with C-section	23
Table of Contents	22
Effects of commonly used analgesics on sleep architecture: a topical review	22
Reply to Hoegh et al.	22
The use of quantitative sensory testing for personalized pain medicine in the age of AI	22
Dose–response relationship and effect modifier of stabilisation exercises in nonspecific low back pain: a project-wide individual patient data re-analysis on 1483 intervention participants	22
Pain relief after topical capsaicin: does it result from nociceptor degeneration or regeneration?	22
The association between parent mental health and pediatric chronic pain: a systematic review and meta-analysis	22
Interpretation bias and the transition from acute to chronic pain	21
Agreement between youth and caregiver report of pain and functioning in pediatric sickle cell disease: PedsQL sickle cell disease module	21
Efficacy and safety of pharmacological, physical, and psychological interventions for the management of chronic pain in children: a WHO systematic review and meta-analysis: Erratum	21
Beyond the ambiguity of interpretation bias for pain-related information	21
Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance: Erratum	21
ATF4 inhibits TRPV4 function and controls itch perception in rodents and nonhuman primates	21
Open data sharing: what could possibly go wrong?	21
Microneurographic portrait of 19 patients with small fiber neuropathy: a pilot study	21
Hypnosis in chronic pain: from new hope to emerging standard?	21
Moving beyond pain intensity as the primary outcome measure: the INTEGRATE pain framework and beyond	21
Assessing spontaneous sensory neuron activity using in vivo calcium imaging	21
Adding a nonpainful end to reduce pain recollection of Pap smear screening: a randomized controlled trial	20
Abdominoplasty as an acute postoperative pain model: insights from 8 years of clinical trials	20
Delphi study to define core clinical outcomes for inclusion in a complex regional pain syndrome international research registry and data bank	20
Pain's puzzle pieces: MAGI-1, NaV1.8, degradation, analgesia	20
Converging inputs compete at the lateral parabrachial nuclei to dictate the affective-motivational responses to cold pain	20
Cannabis use disorder in patients with chronic pain: overestimation and underestimation in a cross-sectional observational study in 3 German pain management centres	20
Inequities in time-to-follow-up care and administrative action after low back pain diagnosis in active duty service members	20
Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception	20
Small nerve fibre pathology in non-neuropathic chronic pain conditions: a systematic review and meta-analysis	20
ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion	20
Digging deeper into pain: an ethological behavior assay correlating well-being in mice with human pain experience	19
Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort	19
Multi-omic integration with human dorsal root ganglia proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway	19
Quantitative sensory testing–based sensory phenotypes align with measures of peripheral nerve damage in patients with painful polyneuropathies	19
Temporal predictability of pain shapes motor system inhibition	18
The thalamic projection of pain sensations to the posterior dorsal fundus in the insula: comment on Mandonnet et al.	18
Salivary metabolome indicates a shift in tyrosine metabolism in patients with burning mouth syndrome: a prospective case–control study	18
Chronic pain in European adult populations: a systematic review of prevalence and associated clinical features	18
Patient preferences in the treatment of chronic musculoskeletal pain: a systematic review of discrete choice experiments	18
Neuroendocrine mechanisms in oxaliplatin-induced hyperalgesic priming	18
A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology	17
Unraveling the puzzle of pain in pancreatic diseases	17
Advances in the analysis of intensive longitudinal pain data: a commentary on Leroux et al.	17
Rostral ventral medulla circuits regulate both the sensory and affective dimensions of neuropathic pain: a commentary on Dogrul et al.	17
“Belief-based” medicine is not evidence-based medicine	17
Quantitative somatosensory testing of the abdomen: establishing initial reference values across developmental age and biological sex	17
Spontaneous activity in pain patient stem cell–derived sensory neurons arises from one functional subclass	17
Informing about side effects: putting patients (preferences) first	17
Reply to Manhapra	17
Demise of nociceptive Schwann cells causes nerve retraction and pain hyperalgesia: Erratum	16
Neuroinflammation drives sex-dependent effects on pain and negative affect in a murine model of repeated mild traumatic brain injury	16
CD304+ adipose tissue–derived mesenchymal stem cell abundance in autologous fat grafts highly correlates with improvement of localized pain syndromes	16
Table of Contents	16
Multimodal hypersensitivity and somatic symptoms predict adolescent postmenarchal widespread pain	16
The associations of opioid and benzodiazepine prescriptions with injuries among US military service members	16
Is there really no association between postoperative opioid use and long-term surgical outcomes in patients diagnosed with liver cancer?	16
Effectiveness of neural mobilisation for the treatment of nerve-related cervicobrachial pain: a systematic review with subgroup meta-analysis	16
Estrous cycle regulates cephalic mechanical sensitivity and sensitization of the trigemino-cervical complex in a female rat model of chronic migraine	16
Three dimensions of pain in osteoarthritis: development and validation of the Osteoarthritis Symptom Inventory Scale	16
Give and take: an evolutionary framework for social transactions in pain	16
CARTp/GPR160 mediates behavioral hypersensitivities in mice through NOD2	16
Chronic pain among U.S. sexual minority adults who identify as gay, lesbian, bisexual, or “something else”: Erratum	16
Accuracy of neuropathic pain measurements in patients with symptoms of polyneuropathy: validation of painDETECT, Self-Completed Leeds Assessment of Neuropathic Symptoms and Signs, and Douleur Neuropat	16
Cutaneous nerve fiber and peripheral Nav1.7 assessment in a large cohort of patients with postherpetic neuralgia	16
Melatonin for neuropathic pain: a double-blind, placebo-controlled, randomized, crossover trial	16
A paraventricular hypothalamic nucleus input to ventral of lateral septal nucleus controls chronic visceral pain	15
Huntington-associated protein 1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation	15
Educational disparities in joint pain within and across US states: do macro sociopolitical contexts matter?	15
Perceiving pain alters body perception: the effects of acute pain on body image and sensory testing	15

Partial heat shock response and transient receptor potential ankyrin 1 sensitization redefine mechanisms of Fabry disease pain	15
MicroRNA let-7b enhances spinal cord nociceptive synaptic transmission and induces acute and persistent pain through neuronal and microglial signaling	15
Topical capsaicin 8% differentially blocks activation of nociceptors by mechanical, heat, and electrical stimuli in human skin	15
Functional coupling between peripheral nociceptor terminals in vivo is enhanced during acute inflammation	15
A randomized, placebo-controlled trial of long-acting dexamethasone viscous gel delivered by transforaminal injection for lumbosacral radicular pain	15
Leveraging value-based health principles to improve translation and impact of digital psychological interventions for people with chronic pain	15
Psychosocial mechanisms underlying the transition from acute to chronic postsurgical pain in youth following spinal fusion: a 6-month longitudinal study	15
Comparing the prevalence of chronic pain in school-aged children in the United States from 2019 to 2020: a nationally representative study examining differences associated with the COVID-19 pandemic:	15
Body image, sex, gender, and pain: towards an improved understanding of pain mechanisms	15
Prediction of the response to repetitive transcranial magnetic stimulation of the motor cortex in peripheral neuropathic pain and validation of a new algorithm	15
Interoception and pain: body–mind integration, rupture, and repair	15
The Canadian version of the National Institutes of Health minimum dataset for chronic low back pain research: reference values from the Quebec Low Back Pain Study	15
Open-label nondeceptive placebo analgesia is blocked by the opioid antagonist naloxone	15
Standardizing research methods for opioid dose comparison: the NIH HEAL morphine milligram equivalent calculator	15
Phenotypic characteristics of chronic pain and pain-related factors in gender minority persons: a cross-sectional study	15
TRPV1 is the burner	15
Deep learning–guided postoperative pain assessment in children	15
Resting-state electroencephalography and magnetoencephalography as biomarkers of chronic pain: a systematic review	15
Unlocking the secrets of daily diary data: can we improve our understanding of the reinforcing effects of pain medication?	14
Reply to Manhapra	14
Reply to Moulton et al.	14
The local molecular signature of human peripheral neuropathic pain	14
Where is the pain? Spatial patterns of pain co-occurrence in a population-based study of 4833 pain drawings incorporating network analysis	14
Educational initiatives and achievements of the International Association for the Study of Pain	14
Reliability and validity of the Pediatric PainSCAN: a screening tool for pediatric neuropathic pain and complex regional pain syndrome	14
Bilateral deficiency of Meissner corpuscles and papillary microvessels in patients with acute complex regional pain syndrome	14
Reply to Zhang and Pan	14
Parental narrative style moderates the relation between pain-related attention and memory biases in youth with chronic pain	14
A call to action to integrate best practice assessment of sexual orientation and gender identity in pain research and clinical care	14
The “External Validity Crisis”: now is the time to address the attack on diversity, equity, and inclusion in pain science	14
Clinical features and functional analysis of novel SCN9A variants causing congenital insensitivity to pain	14
The invisible cost of pain management by the current International Classification of Diseases coding system: a study in a tertiary care inpatient setting	14
The thermal grill elicits central sensitization	14
Lumbar tactile acuity associated with S1-thalamic functional connectivity and S1 microstructure in patients with low back pain and pain-free controls	14
Introduction to the biennial review of pain	14
Reply to Ali	14
Thermal grill illusion of pain in patients with chronic pain: a clinical marker of central sensitization?	14
Most digital psychological interventions for chronic pain fail to measure all 4 dimensions of the quadruple aim of value-based health care: a scoping review	14
Neural mechanisms underlying the conditioned pain modulation response: a narrative review of neuroimaging studies	14
Nociplastic pain—grading the unknown	14
Nucleus accumbens myocyte enhancer factor 2C mediates the maintenance of peripheral nerve injury–induced physiological and behavioral maladaptations	14
Functional and anatomical analyses of active spinal circuits in a mouse model of chronic pain	14
Effects of virtual reality on psychophysical measures of pain: superiority to imagination and nonimmersive conditions	13
Gonadal hormone–dependent nociceptor sensitization maintains nociplastic pain state in female mice	13
Reply to Chen and Yeh	13
Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes	13
Co-occurrence of chronic pain and anxiety/depression symptoms in U.S. adults: prevalence, functional impacts, and opportunities	13
Mirror peripheral neuropathy and unilateral chronic neuropathic pain: insights from asymmetric neurological patterns in leprosy	13
From SARS-CoV-2 to analgesia: harnessing the vascular endothelial growth factor A/neuropilin 1 axis for pain therapy	13
Enhancing healthcare professionals' biopsychosocial perspective to chronic pain: assessing the impact of implementing an interdisciplinary training program	13
Predictors of response to full agonist opioids in enriched enrollment randomized withdrawal clinical trials: a participant-level data meta-analysis	13
Functioning in chronic pain: a call for a global definition	13
Recommendations for patient education in the management of persistent pelvic pain: a systematic review of clinical practice guidelines	13
Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial	13
Bodily maps of emotions and pain: tactile and hedonic sensitivity in healthy controls and patients experiencing chronic pain	13
Reply to Esposto and Cioeta (2023): Clarification regarding classical conditioning and conditioned pain	13
Reply to Karlsen et al. Consensus on a core outcome set: a panel decision	13
A novel potential strategy for the treatment of inflammatory and neuropathic pain	13
Contribution of S1pr1-featured astrocyte subpopulation to cisplatin-induced neuropathic pain in male mice	13
Inhibition of bladder sensory afferents via intrabladder injection of adenoassociated viruses-retro–mediated Gi-DREADDs alleviates bladder overactivity and pain in mice	13
Advancing understanding of opioid mortality risks beyond initial findings in noncancer pain patients	13
Mast cell chymases: essential for preventing the transition from acute to chronic pain	13
Editorial Board	13
Deciphering relationships between stress biomarkers and fibromyalgia syndrome with implications relevant to other chronic pain conditions	13
Do “central sensitization” questionnaires reflect measures of nociceptive sensitization or psychological constructs? A systematic review and meta-analyses	12
Unbiased analysis of the dorsal root ganglion after peripheral nerve injury: no neuronal loss, no gliosis, but satellite glial cell plasticity	12
Characterizing high-cost healthcare users among adults with back pain in Ontario, Canada: a population-based cohort study	12
Elevated 18:0 lysophosphatidylcholine contributes to the development of pain in tissue injury	12
Patient engagement in pain research: no gain without the people in pain	12
Reply to Blomqvist and Evrard	12
A double-blind phase II randomized controlled trial of an online cognitive bias modification for interpretation program with and without psychoeducation for people with chronic pain	12
A randomized-controlled pilot trial of telemedicine-delivered cognitive-behavioral therapy tailored for interstitial cystitis/bladder pain syndrome	12
TRPM3 as a novel target to alleviate acute oxaliplatin-induced peripheral neuropathic pain	12
Haves and have-nots: socioeconomic position improves accuracy of machine learning algorithms for predicting high-impact chronic pain	12
Referred sensations in the orofacial region are associated with a decreased descending pain inhibition and modulated by remote noxious stimuli and local anesthesia	12
Expectations underlie the effects of unpredictable pain: a behavioral and electroencephalogram study	12
A catheter-associated urinary tract infection mouse model to study bladder dysfunction and pain	12
Selection of corticosteroids for epidural steroid injections	12
miR-1306-3p directly activates P2X3 receptors in primary sensory neurons to induce visceral pain in rats	12
Brain predicted age in chronic pelvic pain: a study by the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network	12
Momentary assessment of mental imagery and pain-related psychological factors in youth with chronic pain	12
Descending mechanism by which medial prefrontal cortex endocannabinoid signaling controls the development of neuropathic pain and neuronal activity of dorsal root ganglion	12
Behavioral cancer pain intervention dosing: results of a Sequential Multiple Assignment Randomized Trial	12
Is blue light a red herring in a rodent model of “computer vision syndrome”?	12
Serum levels of endocannabinoids and related lipids in painful vs painless diabetic neuropathy: results from the Pain in Neuropathy Study	12
Potentiation of visualized exosomal miR-1306-3p from primary sensory neurons contributes to chronic visceral pain via spinal P2X3 receptors	12
Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter p	12
Immunotherapy, a new approach for the treatment of human pain	12
Peripheral contributions to offset analgesia: effects of stimulus duration, intensity, and location	12
Sleep disruption and activation of cellular inflammation mediate heightened pain sensitivity: a randomized clinical trial	12
The influence of chronotype on pain: a systematic review and meta-analysis	12
Randomized controlled trials of pain treatment: essential research tools, a framework for clinical care	11
Reductions in kinesiophobia and distress after pain neuroscience education and exercise lead to favourable outcomes: a secondary mediation analysis of a randomized controlled trial in primary care	11
Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study	11
The descending modulation of pain	11