Pain

Article	Citations
Translational control by general control nonderepressible 2 kinase regulates methylglyoxal-induced pain in mice	222
Unrelieved pain and risk of opioid use disorder or overdose in older adults prescribed opioids	167
Benign or painful? The interpretation of pain and fear of progression in rheumatoid arthritis	109
Pediatric chronic pain grading: a revised classification of the severity of pediatric chronic pain	106
Adenosine causes short-lasting vasodilation and headache but not migraine attacks in migraine patients: a randomized clinical trial	106
Autoantibodies in patients with fibromyalgia syndrome	97
The social nature of human pain	85
Chemokines as targets to treat chronic postoperative pain	77
The impact of opioid withdrawal symptoms on pain outcomes in enriched enrollment randomized withdrawal trials: a mediation meta-analysis of trials submitted to the US Food and Drug Administration	74
Sex differences in pain expressed by patients across diverse disease states: individual patient data meta-analysis of 33,957 participants in 10 randomized controlled trials	72
Diagnostic accuracy of quantitative sensory testing for detecting small fiber impairment in polyneuropathy and diagnosing small fiber neuropathy	64
Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project)	63
Sex differences in visceral sensitivity and brain activity in a rat model of comorbid pain: a longitudinal study	62
C–C motif chemokine ligand 12 (CCL12) is a critical chemokine driving postoperative pain	60
Table of Contents	58
Showcasing scientific discovery in PAIN: an opportunity for authors	55
Episodic pain in Fabry disease is mediated by a heat shock protein-transient receptor potential cation channel A1 axis	54
White matter microstructural associations with pain experiences in a large community sample of youth	54
Intrinsic and synaptic properties of adult mouse spinoperiaqueductal gray neurons and the influence of neonatal tissue damage	50
Selective targeting of voltage-gated sodium channels to achieve analgesia: current status and future directions	49
Reply to dos Santos Ferreira and Velly	48
Association between prescribed opioid dose and risk of motor vehicle crashes	48
Future perspectives: the next fifty years of the International Association for the Study of Pain	47
Reply to Currie et al.	46
Validation of ICD-11 chronic pain severity specifiers for children and adolescents: an important step forward	45

Painful distortions: people with painful knee osteoarthritis have biased visuospatial perception of the environment	44
Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood: The HUNT Study	43
Innovative cognitive behavioral therapies for irritable bowel syndrome: processes, predictors, platforms, and outcomes	43
Neuropilin-1 is essential for vascular endothelial growth factor A–mediated increase of sensory neuron activity and development of pain-like behaviors	41
Data-driven identification of distinct pain drawing patterns and their association with clinical and psychological factors: a study of 21,123 patients with spinal pain	41
Reply to Quintner	39
The future of pain research: neuromodulation and surgery	39
Gut microbiota dysbiosis alters chronic pain behaviors in a humanized transgenic mouse model of sickle cell disease	38
Chronic pain is specifically associated with updating working memory: a longitudinal twin study	37
Statistical modeling of acute and chronic pain patient-reported outcomes obtained from ecological momentary assessment	37
On the adverse effects of gabapentinoids	37
Subjective salience ratings are a reliable proxy for physiological measures of arousal	36
Vaso-occlusive crisis pain intensity, frequency, and duration: which best correlates with health-related quality of life in adolescents and adults with sickle cell disease?	36
The contribution of baseline circulating endocannabinoids to individual differences in human pain sensitivity: a quantitative sensory testing study	36
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients	36
Improving the art and science of communication in people living with chronic pain	36
Description and initial validation of a novel measure of pain intensity: the Numeric Rating Scale of Underlying Pain without concurrent Analgesic use	35
Sex differences in facial expressions of pain: results from a combined sample	34
Widespread hyperexcitability of nociceptor somata outlasts enhanced avoidance behavior after incision injury	34
Unintended prolonged opioid use: a prospective case–control study	33
Alzheimer disease may compromise patients' ability for expectancy-based pain modulation. Now what?	33
Increasing risk of cannabis use disorder among U.S. veterans with chronic pain: 2005-2019	32
Prevalence and correlates of “undiagnosed pain”: evidence from the US national Medical Expenditure Panel Survey	32
TRESK background potassium channel regulates MrgprA3+ pruriceptor excitability, acute and chronic itch	32
Gaining a new footing on molecular mechanisms of neuropathic pain in patients	32
The impact of chronic pain on brain gene expression	31
[11C]-PBR28 positron emission tomography signal as an imaging marker of joint inflammation in knee osteoarthritis	31
Peripheral and central neurobiological effects of botulinum toxin A (BoNT/A) in neuropathic pain: a systematic review	31
Forward and reverse engineering the pain system: from computational neuroscience to neuro-engineering	30
Reply to Andrassy and Mukhdomi	30
Leveraging technologies to upskill primary care providers in person-centred pain care	30
Multisite chronic pain as a causal risk factor for coronary artery disease: findings from Mendelian randomization	30
Editorial Board	30
How the next 50 years of positron emission tomography can transform our understanding of chronic pain	29
Progression trajectories of chronic overlapping pain conditions unveiled across two large clinical data warehouses	28
Effects of transcranial ultrasound stimulation of primary somatosensory cortex and ventral posterolateral nucleus of the thalamus on acute pain perception	28
Social disparities in pain	28
Efficacy and safety of eliapixant in diabetic neuropathic pain and prediction of placebo responders with an exploratory novel algorithm: results from the randomized controlled phase 2a PUCCINI study	28
Paradoxical heat sensation as a manifestation of thermal hypesthesia: a study of 1090 patients with lesions of the somatosensory system: erratum	28
Adjunctive virtual reality pain relief after traumatic injury: a proof-of-concept within-person randomized trial	28
Transcranial direct current stimulation of primary motor cortex reduces thermal pain	27
Rejuvenation alleviates prolonged postsurgical pain in aging mice by mitigating inflammaging	27
Thermal grill–induced pain: further evidence for its pathophysiological and clinical relevance	26
Astrocytogenic bidirectional plasticity at spinal nociceptive synapses regulates acute nociceptive processing	26
Region-specific changes in brain glutamate and gamma-aminobutyric acid across the migraine attack in children and adolescents	26
Reliability of quantitative sensory testing in the assessment of somatosensory function after high-frequency stimulation–induced sensitisation of central nociceptive pathways	26
Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus	26
Incidence of chronic pelvic pain after childbirth and its causal association with C-section	25
Reply to Rattanapitoon et al.	25
Dyspareunia: a novel clinical approach for diagnosis based on pain mechanisms	25

Prevalence and characterization of pediatric-onset spinal cord injury pain as reported by youth: an observational and case control association study with TRPA1 gene single nucleotide polymorphisms	25
Effect modifiers of virtual reality in pain management: a systematic review and meta-regression analysis	24
Educational needs and preferences of adult patients with acute pain: a mixed-methods systematic review	24
Association between physiotherapy utilization and medical healthcare utilization and costs in adults with back pain from Ontario, Canada: a population-based cohort study	24
Social support and the association between post-traumatic stress disorder and risk for long-term prescription opioid use	24
Application of neurite orientation dispersion and density imaging in characterizing brain microstructural changes in classical trigeminal neuralgia and a comparison between the left and right sides	24
Who develops chronic pain after an acute lower limb injury? A longitudinal study of children and adolescents	24
Cannabis use disorder in patients with chronic pain: overestimation and underestimation in a cross-sectional observational study in 3 German pain management centres	23
Formation of perineuronal nets within a thalamocortical circuit shapes mechanical and thermal pain thresholds in mice with neuropathic pain	23
The biopsychosocial model of pain 40 years on: time for a reappraisal?	23
Reply to Chang, Gau, and Jhang	23
Towards a tool to discriminate between pain mechanistic descriptors: expert ranking of clinical features and allocation of weights using a forced choice paradigm	23
Beyond the ambiguity of interpretation bias for pain-related information	23
Open data sharing: what could possibly go wrong?	23
Opioid dose and pain effects of an online pain self-management program to augment usual care in adults with chronic pain: a multisite randomized clinical trial	23
Neuroendocrine mechanisms in oxaliplatin-induced hyperalgesic priming	23
ATF4 inhibits TRPV4 function and controls itch perception in rodents and nonhuman primates	22
Delphi study to define core clinical outcomes for inclusion in a complex regional pain syndrome international research registry and data bank	22
Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort	22
Inequities in time-to-follow-up care and administrative action after low back pain diagnosis in active duty service members	22
Efficacy and safety of pharmacological, physical, and psychological interventions for the management of chronic pain in children: a WHO systematic review and meta-analysis: Erratum	22
ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion	22
Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance: Erratum	21
Spontaneous activity in pain patient stem cell–derived sensory neurons arises from one functional subclass	21
Microneurographic portrait of 19 patients with small fiber neuropathy: a pilot study	21
The thalamic projection of pain sensations to the posterior dorsal fundus in the insula: comment on Mandonnet et al.	21
Pain relief after topical capsaicin: does it result from nociceptor degeneration or regeneration?	21
Dose–response relationship and effect modifier of stabilisation exercises in nonspecific low back pain: a project-wide individual patient data re-analysis on 1483 intervention participants	21
Table of Contents	21
Agreement between youth and caregiver report of pain and functioning in pediatric sickle cell disease: PedsQL sickle cell disease module	21
Reply to Hoegh et al.	21
Interpretation bias and the transition from acute to chronic pain	21
Hypnosis in chronic pain: from new hope to emerging standard?	20
Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception	20
Adding a nonpainful end to reduce pain recollection of Pap smear screening: a randomized controlled trial	20
Assessing spontaneous sensory neuron activity using in vivo calcium imaging	20
Renaming burning mouth syndrome: implications and use for the Research Diagnostic Criteria for Burning Mouth Syndrome	20
Moving beyond pain intensity as the primary outcome measure: the INTEGRATE pain framework and beyond	20
Patient preferences in the treatment of chronic musculoskeletal pain: a systematic review of discrete choice experiments	20
A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology	20
Effects of commonly used analgesics on sleep architecture: a topical review	20
Quantitative sensory testing–based sensory phenotypes align with measures of peripheral nerve damage in patients with painful polyneuropathies	20
Digging deeper into pain: an ethological behavior assay correlating well-being in mice with human pain experience	19
Multi-omic integration with human dorsal root ganglia proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway	19
Grpr expression defines a population of superficial dorsal horn vertical cells that have a role in both itch and pain	19
Chronic pain in European adult populations: a systematic review of prevalence and associated clinical features	19
The association between parent mental health and pediatric chronic pain: a systematic review and meta-analysis	19
Salivary metabolome indicates a shift in tyrosine metabolism in patients with burning mouth syndrome: a prospective case–control study	19
Converging inputs compete at the lateral parabrachial nuclei to dictate the affective-motivational responses to cold pain	19
Abdominoplasty as an acute postoperative pain model: insights from 8 years of clinical trials	19
Small nerve fibre pathology in non-neuropathic chronic pain conditions: a systematic review and meta-analysis	19
Pain's puzzle pieces: MAGI-1, NaV1.8, degradation, analgesia	19
Rostral ventral medulla circuits regulate both the sensory and affective dimensions of neuropathic pain: a commentary on Dogrul et al.	19
The use of quantitative sensory testing for personalized pain medicine in the age of AI	19
“Belief-based” medicine is not evidence-based medicine	18
CARTp/GPR160 mediates behavioral hypersensitivities in mice through NOD2	18
Informing about side effects: putting patients (preferences) first	18
Quantitative somatosensory testing of the abdomen: establishing initial reference values across developmental age and biological sex	18
Reply to Manhapra	18
Unraveling the puzzle of pain in pancreatic diseases	18
Advances in the analysis of intensive longitudinal pain data: a commentary on Leroux et al.	18
Effectiveness of neural mobilisation for the treatment of nerve-related cervicobrachial pain: a systematic review with subgroup meta-analysis	17
Is there really no association between postoperative opioid use and long-term surgical outcomes in patients diagnosed with liver cancer?	17
Perceiving pain alters body perception: the effects of acute pain on body image and sensory testing	17
The associations of opioid and benzodiazepine prescriptions with injuries among US military service members	17
Neuroinflammation drives sex-dependent effects on pain and negative affect in a murine model of repeated mild traumatic brain injury	17
Chronic pain among U.S. sexual minority adults who identify as gay, lesbian, bisexual, or “something else”: Erratum	17
CD304+ adipose tissue–derived mesenchymal stem cell abundance in autologous fat grafts highly correlates with improvement of localized pain syndromes	17
Demise of nociceptive Schwann cells causes nerve retraction and pain hyperalgesia: Erratum	17
The Canadian version of the National Institutes of Health minimum dataset for chronic low back pain research: reference values from the Quebec Low Back Pain Study	17
MicroRNA let-7b enhances spinal cord nociceptive synaptic transmission and induces acute and persistent pain through neuronal and microglial signaling	17
Estrous cycle regulates cephalic mechanical sensitivity and sensitization of the trigemino-cervical complex in a female rat model of chronic migraine	16
Table of Contents	16
Psychosocial mechanisms underlying the transition from acute to chronic postsurgical pain in youth following spinal fusion: a 6-month longitudinal study	16
A randomized, placebo-controlled trial of long-acting dexamethasone viscous gel delivered by transforaminal injection for lumbosacral radicular pain	16
Give and take: an evolutionary framework for social transactions in pain	16
Cutaneous nerve fiber and peripheral Nav1.7 assessment in a large cohort of patients with postherpetic neuralgia	16
Three dimensions of pain in osteoarthritis: development and validation of the Osteoarthritis Symptom Inventory Scale	16
Prediction of the response to repetitive transcranial magnetic stimulation of the motor cortex in peripheral neuropathic pain and validation of a new algorithm	16
Mechanisms and manifestations in musculoskeletal pain: from experimental to clinical pain settings	16

Melatonin for neuropathic pain: a double-blind, placebo-controlled, randomized, crossover trial	16
Accuracy of neuropathic pain measurements in patients with symptoms of polyneuropathy: validation of painDETECT, Self-Completed Leeds Assessment of Neuropathic Symptoms and Signs, and Douleur Neuropat	16
Functional coupling between peripheral nociceptor terminals in vivo is enhanced during acute inflammation	16
Interoception and pain: body–mind integration, rupture, and repair	16
Multimodal hypersensitivity and somatic symptoms predict adolescent postmenarchal widespread pain	16
Upregulation of LncRNA71132 in the spinal cord regulates hypersensitivity in a rat model of bone cancer pain	16
The invisible cost of pain management by the current International Classification of Diseases coding system: a study in a tertiary care inpatient setting	15
Inhibition of bladder sensory afferents via intrabladder injection of adenoassociated viruses-retro–mediated Gi-DREADDs alleviates bladder overactivity and pain in mice	15
Huntington-associated protein 1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation	15
Parental narrative style moderates the relation between pain-related attention and memory biases in youth with chronic pain	15
Open-label nondeceptive placebo analgesia is blocked by the opioid antagonist naloxone	15
Leveraging value-based health principles to improve translation and impact of digital psychological interventions for people with chronic pain	15
Comparing the prevalence of chronic pain in school-aged children in the United States from 2019 to 2020: a nationally representative study examining differences associated with the COVID-19 pandemic:	15
Nucleus accumbens myocyte enhancer factor 2C mediates the maintenance of peripheral nerve injury–induced physiological and behavioral maladaptations	15
Bilateral deficiency of Meissner corpuscles and papillary microvessels in patients with acute complex regional pain syndrome	15
A paraventricular hypothalamic nucleus input to ventral of lateral septal nucleus controls chronic visceral pain	15
Biopsychosocial influence on shoulder pain: results from a randomized preclinical trial of exercise-induced muscle injury	15
Partial heat shock response and transient receptor potential ankyrin 1 sensitization redefine mechanisms of Fabry disease pain	15
Standardizing research methods for opioid dose comparison: the NIH HEAL morphine milligram equivalent calculator	15
Educational disparities in joint pain within and across US states: do macro sociopolitical contexts matter?	15
TRPV1 is the burner	15
Educational initiatives and achievements of the International Association for the Study of Pain	15
Reply to Zhang and Pan	15
Deep learning–guided postoperative pain assessment in children	15
Resting-state electroencephalography and magnetoencephalography as biomarkers of chronic pain: a systematic review	15
Phenotypic characteristics of chronic pain and pain-related factors in gender minority persons: a cross-sectional study	15
Body image, sex, gender, and pain: towards an improved understanding of pain mechanisms	14
Lumbar tactile acuity associated with S1-thalamic functional connectivity and S1 microstructure in patients with low back pain and pain-free controls	14
Clinical features and functional analysis of novel SCN9A variants causing congenital insensitivity to pain	14
Reply to Ali	14
Reply to Manhapra	14
Reliability and validity of the Pediatric PainSCAN: a screening tool for pediatric neuropathic pain and complex regional pain syndrome	14
Most digital psychological interventions for chronic pain fail to measure all 4 dimensions of the quadruple aim of value-based health care: a scoping review	14
The thermal grill elicits central sensitization	14
Effects of virtual reality on psychophysical measures of pain: superiority to imagination and nonimmersive conditions	14
Predictors of response to full agonist opioids in enriched enrollment randomized withdrawal clinical trials: a participant-level data meta-analysis	14
Where is the pain? Spatial patterns of pain co-occurrence in a population-based study of 4833 pain drawings incorporating network analysis	14
A novel potential strategy for the treatment of inflammatory and neuropathic pain	14
Unlocking the secrets of daily diary data: can we improve our understanding of the reinforcing effects of pain medication?	14
Reply to Chen and Yeh	14
Thermal grill illusion of pain in patients with chronic pain: a clinical marker of central sensitization?	14
Bodily maps of emotions and pain: tactile and hedonic sensitivity in healthy controls and patients experiencing chronic pain	14
Functional and anatomical analyses of active spinal circuits in a mouse model of chronic pain	14
Nociplastic pain—grading the unknown	14
Introduction to the biennial review of pain	14
Reply to Moulton et al.	14
Gonadal hormone–dependent nociceptor sensitization maintains nociplastic pain state in female mice	14
Neural mechanisms underlying the conditioned pain modulation response: a narrative review of neuroimaging studies	14
Co-occurrence of chronic pain and anxiety/depression symptoms in U.S. adults: prevalence, functional impacts, and opportunities	13
Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial	13
From SARS-CoV-2 to analgesia: harnessing the vascular endothelial growth factor A/neuropilin 1 axis for pain therapy	13
Reply to Karlsen et al. Consensus on a core outcome set: a panel decision	13
Immunotherapy, a new approach for the treatment of human pain	13
Mirror peripheral neuropathy and unilateral chronic neuropathic pain: insights from asymmetric neurological patterns in leprosy	13
The local molecular signature of human peripheral neuropathic pain	13
Recommendations for patient education in the management of persistent pelvic pain: a systematic review of clinical practice guidelines	13
Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes	13
Contribution of S1pr1-featured astrocyte subpopulation to cisplatin-induced neuropathic pain in male mice	13
Reply to Esposto and Cioeta (2023): Clarification regarding classical conditioning and conditioned pain	13
Deciphering relationships between stress biomarkers and fibromyalgia syndrome with implications relevant to other chronic pain conditions	13
Is blue light a red herring in a rodent model of “computer vision syndrome”?	13
Functioning in chronic pain: a call for a global definition	13
Enhancing healthcare professionals' biopsychosocial perspective to chronic pain: assessing the impact of implementing an interdisciplinary training program	13
A call to action to integrate best practice assessment of sexual orientation and gender identity in pain research and clinical care	13
Mast cell chymases: essential for preventing the transition from acute to chronic pain	13
Editorial Board	13
Reply to Blomqvist and Evrard	13
Selection of corticosteroids for epidural steroid injections	13
The “External Validity Crisis”: now is the time to address the attack on diversity, equity, and inclusion in pain science	13
Potentiation of visualized exosomal miR-1306-3p from primary sensory neurons contributes to chronic visceral pain via spinal P2X3 receptors	12
A catheter-associated urinary tract infection mouse model to study bladder dysfunction and pain	12
Expectations underlie the effects of unpredictable pain: a behavioral and electroencephalogram study	12
Elevated 18:0 lysophosphatidylcholine contributes to the development of pain in tissue injury	12
Intrathecal administration of the Nav1.7 inhibitor PF-05089771 produces rapid and side-effect-free analgesia in mice	12
Clinical improvements due to specific effects and placebo effects in conservative interventions and changes observed with no treatment in randomized controlled trials of patients with chronic nonspeci	12
Momentary assessment of mental imagery and pain-related psychological factors in youth with chronic pain	12
Brain predicted age in chronic pelvic pain: a study by the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network	12
Characterizing high-cost healthcare users among adults with back pain in Ontario, Canada: a population-based cohort study	12
Peripheral contributions to offset analgesia: effects of stimulus duration, intensity, and location	12
Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter p	12
miR-1306-3p directly activates P2X3 receptors in primary sensory neurons to induce visceral pain in rats	12
A double-blind phase II randomized controlled trial of an online cognitive bias modification for interpretation program with and without psychoeducation for people with chronic pain	12
Sleep disruption and activation of cellular inflammation mediate heightened pain sensitivity: a randomized clinical trial	12
The bidirectional relationship between sleep problems and chronic musculoskeletal pain: a systematic review with meta-analysis	12
TRPM3 as a novel target to alleviate acute oxaliplatin-induced peripheral neuropathic pain	12
Serum levels of endocannabinoids and related lipids in painful vs painless diabetic neuropathy: results from the Pain in Neuropathy Study	12
Haves and have-nots: socioeconomic position improves accuracy of machine learning algorithms for predicting high-impact chronic pain	12
Advancing understanding of opioid mortality risks beyond initial findings in noncancer pain patients	12
Patient engagement in pain research: no gain without the people in pain	12
Descending mechanism by which medial prefrontal cortex endocannabinoid signaling controls the development of neuropathic pain and neuronal activity of dorsal root ganglion	12
Unbiased analysis of the dorsal root ganglion after peripheral nerve injury: no neuronal loss, no gliosis, but satellite glial cell plasticity	12
A randomized-controlled pilot trial of telemedicine-delivered cognitive-behavioral therapy tailored for interstitial cystitis/bladder pain syndrome	12
Referred sensations in the orofacial region are associated with a decreased descending pain inhibition and modulated by remote noxious stimuli and local anesthesia	12
Promoting multidisciplinary pain management in low- and middle-income countries—challenges and achievements	11
Mechanisms of chronic pain in inflammatory rheumatism: the role of descending modulation	11