Pain

Article	Citations
Chronic pain is specifically associated with updating working memory: a longitudinal twin study	318
Unrelieved pain and risk of opioid use disorder or overdose in older adults prescribed opioids	163
Validation of ICD-11 chronic pain severity specifiers for children and adolescents: an important step forward	102
Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons	85
Description and initial validation of a novel measure of pain intensity: the Numeric Rating Scale of Underlying Pain without concurrent Analgesic use	84
Reply to Venda Nova et al.	76
Adenosine causes short-lasting vasodilation and headache but not migraine attacks in migraine patients: a randomized clinical trial	69
Improving the art and science of communication in people living with chronic pain	67
Sex differences in facial expressions of pain: results from a combined sample	66
Vaso-occlusive crisis pain intensity, frequency, and duration: which best correlates with health-related quality of life in adolescents and adults with sickle cell disease?	63
White matter microstructural associations with pain experiences in a large community sample of youth	62
The social nature of human pain	60
Intersectional identity approach to chronic pain disparities using latent class analysis	60
Benign or painful? The interpretation of pain and fear of progression in rheumatoid arthritis	58
Pediatric chronic pain grading: a revised classification of the severity of pediatric chronic pain	57
Sex differences in visceral sensitivity and brain activity in a rat model of comorbid pain: a longitudinal study	57
Statistical modeling of acute and chronic pain patient-reported outcomes obtained from ecological momentary assessment	54
Whiplash injuries associated with experienced pain and disability can be visualized with [11C]-D-deprenyl positron emission tomography and computed tomography	53
Neuropathic pain and neurocognitive functioning in children treated for acute lymphoblastic leukemia	52
Reply to dos Santos Ferreira and Velly	52
Innovative cognitive behavioral therapies for irritable bowel syndrome: processes, predictors, platforms, and outcomes	52
Reply to Quintner	48
Association between prescribed opioid dose and risk of motor vehicle crashes	47
Sex differences in pain expressed by patients across diverse disease states: individual patient data meta-analysis of 33,957 participants in 10 randomized controlled trials	44
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients	44

Widespread hyperexcitability of nociceptor somata outlasts enhanced avoidance behavior after incision injury	42
Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood: The HUNT Study	42
Future perspectives: the next fifty years of the International Association for the Study of Pain	41
Autoantibodies in patients with fibromyalgia syndrome	40
Reply to Currie et al.	40
Painful distortions: people with painful knee osteoarthritis have biased visuospatial perception of the environment	40
On the adverse effects of gabapentinoids	39
Gut microbiota dysbiosis alters chronic pain behaviors in a humanized transgenic mouse model of sickle cell disease	38
Intrinsic and synaptic properties of adult mouse spinoperiaqueductal gray neurons and the influence of neonatal tissue damage	37
Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project)	36
Data-driven identification of distinct pain drawing patterns and their association with clinical and psychological factors: a study of 21,123 patients with spinal pain	35
Neuropilin-1 is essential for vascular endothelial growth factor A–mediated increase of sensory neuron activity and development of pain-like behaviors	35
Application of neurite orientation dispersion and density imaging in characterizing brain microstructural changes in classical trigeminal neuralgia and a comparison between the left and right sides	34
Gaining a new footing on molecular mechanisms of neuropathic pain in patients	34
Region-specific changes in brain glutamate and gamma-aminobutyric acid across the migraine attack in children and adolescents	34
Automated detection of squint as a sensitive assay of sex-dependent calcitonin gene–related peptide and amylin-induced pain in mice	34
Formation of perineuronal nets within a thalamocortical circuit shapes mechanical and thermal pain thresholds in mice with neuropathic pain	34
Reply to Andrassy and Mukhdomi	33
TRESK background potassium channel regulates MrgprA3+ pruriceptor excitability, acute and chronic itch	33
Incidence of chronic pelvic pain after childbirth and its causal association with C-section	33
Association between physiotherapy utilization and medical healthcare utilization and costs in adults with back pain from Ontario, Canada: a population-based cohort study	33
Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus	33
Transmembrane protein TMEM184B is necessary for interleukin-31–induced itch	33
Brain predictors of multisite pain onset in children	32
Paradoxical heat sensation as a manifestation of thermal hypesthesia: a study of 1090 patients with lesions of the somatosensory system: erratum	32
Can we improve patient outcomes through using evidence-based opioid deprescribing guidelines to reduce opioid use?	32
Trajectories of distress regulation during preschool vaccinations: child and caregiver predictors	32
Decrease in pain perception during acute SARS-CoV-2 infection: a case series	31
Peripheral and central neurobiological effects of botulinum toxin A (BoNT/A) in neuropathic pain: a systematic review	30
Opioid dose and pain effects of an online pain self-management program to augment usual care in adults with chronic pain: a multisite randomized clinical trial	30
Reliability of quantitative sensory testing in the assessment of somatosensory function after high-frequency stimulation–induced sensitisation of central nociceptive pathways	29
Multisite chronic pain as a causal risk factor for coronary artery disease: findings from Mendelian randomization	29
Social support and the association between post-traumatic stress disorder and risk for long-term prescription opioid use	29
Alzheimer disease may compromise patients' ability for expectancy-based pain modulation. Now what?	29
Efficacy and safety of eliapixant in diabetic neuropathic pain and prediction of placebo responders with an exploratory novel algorithm: results from the randomized controlled phase 2a PUCCINI study	28
Social integration of adolescents with chronic pain: a social network analysis	28
Lysophosphatidic acid activates nociceptors and causes pain or itch depending on the application mode in human skin	28
Impact of variability in baseline pain on the placebo response in randomized, placebo-controlled, crossover trials in peripheral neuropathic pain	28
Progression trajectories of chronic overlapping pain conditions unveiled across two large clinical data warehouses	28
Who develops chronic pain after an acute lower limb injury? A longitudinal study of children and adolescents	28
Oxidative stress is associated with characteristic features of the dysfunctional chronic pain phenotype	27
[11C]-PBR28 positron emission tomography signal as an imaging marker of joint inflammation in knee osteoarthritis	27
Increasing risk of cannabis use disorder among U.S. veterans with chronic pain: 2005-2019	27
Effect modifiers of virtual reality in pain management: a systematic review and meta-regression analysis	27
Educational needs and preferences of adult patients with acute pain: a mixed-methods systematic review	27
The biopsychosocial model of pain 40 years on: time for a reappraisal?	27
Muscle function, quality, and relative mass are associated with knee pain trajectory over 10.7 years	26
Beyond the ambiguity of interpretation bias for pain-related information	26
Behavioral outcomes of complete Freund adjuvant–induced inflammatory pain in the rodent hind paw: a systematic review and meta-analysis	26
Converging inputs compete at the lateral parabrachial nuclei to dictate the affective-motivational responses to cold pain	26

Inequities time-to-follow-up care and administrative action after low back pain diagnosis in active duty service members	26
Adjunctive virtual reality pain relief after traumatic injury: a proof-of-concept within-person randomized trial	26
Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance: Erratum	25
ATF4 inhibits TRPV4 function and controls itch perception in rodents and nonhuman primates	25
Assessing spontaneous sensory neuron activity using in vivo calcium imaging	25
A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology	25
To persist or not to persist? The dilemma of goal adjustment in chronic pain	25
Resting-state occipital alpha power is associated with treatment outcome in patients with chronic migraine	25
Interpretation bias and the transition from acute to chronic pain	25
Grpr expression defines a population of superficial dorsal horn vertical cells that have a role in both itch and pain	24
Efficacy and safety of pharmacological, physical, and psychological interventions for the management of chronic pain in children: a WHO systematic review and meta-analysis: Erratum	24
Digging deeper into pain: an ethological behavior assay correlating well-being in mice with human pain experience	24
Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception	24
Agreement between youth and caregiver report of pain and functioning in pediatric sickle cell disease: PedsQL sickle cell disease module	24
Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort	24
Positive affect and distraction enhance whereas negative affect impairs pain modulation in patients with recurrent low back pain and matched controls	24
Abdominoplasty as an acute postoperative pain model: insights from 8 years of clinical trials	23
Renaming burning mouth syndrome: implications and use for the Research Diagnostic Criteria for Burning Mouth Syndrome	23
Pain relief after topical capsaicin: does it result from nociceptor degeneration or regeneration?	23
Delphi study to define core clinical outcomes for inclusion in a complex regional pain syndrome international research registry and data bank	23
ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion	22
Patient preferences in the treatment of chronic musculoskeletal pain: a systematic review of discrete choice experiments	22
Reply to Hoegh et al.	22
Pain's puzzle pieces: MAGI-1, NaV1.8, degradation, analgesia	21
Adding a nonpainful end to reduce pain recollection of Pap smear screening: a randomized controlled trial	21
Dose–response relationship and effect modifier of stabilisation exercises in nonspecific low back pain: a project-wide individual patient data re-analysis on 1483 intervention participants	21
A syngeneic inoculation mouse model of endometriosis that develops multiple comorbid visceral and cutaneous pain like behaviours	21
Effects of commonly used analgesics on sleep architecture: a topical review	21
Chronic pain in European adult populations: a systematic review of prevalence and associated clinical features	21
Cannabis use disorder in patients with chronic pain: overestimation and underestimation in a cross-sectional observational study in 3 German pain management centres	21
The association between parent mental health and pediatric chronic pain: a systematic review and meta-analysis	21
Microneurographic portrait of 19 patients with small fiber neuropathy—A pilot study	20
Neuroendocrine mechanisms in oxaliplatin-induced hyperalgesic priming	20
Examination of the contribution of Nav1.7 to axonal propagation in nociceptors	20
Salivary metabolome indicates a shift in tyrosine metabolism in patients with burning mouth syndrome: a prospective case–control study	20
Enhanced mindfulness-based stress reduction in episodic migraine—effects on sleep quality, anxiety, stress, and depression: a secondary analysis of a randomized clinical trial	20
Multi-omic integration with human dorsal root ganglia proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway	20
The thalamic projection of pain sensations to the posterior dorsal fundus in the insula: comment on Mandonnet et al.	20
Chronic pain among U.S. sexual minority adults who identify as gay, lesbian, bisexual, or “something else”: Erratum	19
Multimodal hypersensitivity and somatic symptoms predict adolescent postmenarchal widespread pain	19
Interoception and pain: body–mind integration, rupture, and repair	19
Informing about side effects: putting patients (preferences) first	19
Rostral ventral medulla circuits regulate both the sensory and affective dimensions of neuropathic pain: a commentary on Dogrul et al.	19
Upregulation of LncRNA71132 in the spinal cord regulates hypersensitivity in a rat model of bone cancer pain	19
Give and take: an evolutionary framework for social transactions in pain	19
Quantitative somatosensory testing of the abdomen: establishing initial reference values across developmental age and biological sex	18
Chronic pain in the 11th Revision of the International Classification of Diseases: users' questions answered	18
Long-term alterations in somatosensory functioning in survivors of childhood cancer	18
Melatonin for neuropathic pain: a double-blind, placebo-controlled, randomized, crossover trial	18
Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: implications in pain	18
A randomized, placebo-controlled trial of long-acting dexamethasone viscous gel delivered by transforaminal injection for lumbosacral radicular pain	18
Demise of nociceptive Schwann cells causes nerve retraction and pain hyperalgesia: Erratum	18
Estrous cycle regulates cephalic mechanical sensitivity and sensitization of the trigemino-cervical complex in a female rat model of chronic migraine	18
Associations of opioid prescription dose and discontinuation with risk of substance-related morbidity in long-term opioid therapy	18
“Belief-based” medicine is not evidence-based medicine	18
Realigning the role of quantitative sensory testing in sensory profiling of patients with and without neuropathic pain	18
The associations of opioid and benzodiazepine prescriptions with injuries among US military service members	18
Open-label nondeceptive placebo analgesia is blocked by the opioid antagonist naloxone	17
Mechanisms and manifestations in musculoskeletal pain: from experimental to clinical pain settings	17
Unraveling the puzzle of pain in pancreatic diseases	17
Accuracy of neuropathic pain measurements in patients with symptoms of polyneuropathy: validation of painDETECT, Self-Completed Leeds Assessment of Neuropathic Symptoms and Signs, and Douleur Neuropat	17
Biopsychosocial influence on shoulder pain: results from a randomized preclinical trial of exercise-induced muscle injury	17
Deep learning–guided postoperative pain assessment in children	17
Reply to Manhapra	17
The Canadian version of the National Institutes of Health minimum dataset for chronic low back pain research: reference values from the Quebec Low Back Pain Study	17
Huntington-associated protein 1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation	17
Is there really no association between postoperative opioid use and long-term surgical outcomes in patients diagnosed with liver cancer?	16
CD304+ adipose tissue–derived mesenchymal stem cell abundance in autologous fat grafts highly correlates with improvement of localized pain syndromes	16
CARTp/GPR160 mediates behavioral hypersensitivities in mice through NOD2	16
Profiling the molecular signature of satellite glial cells at the single cell level reveals high similarities between rodents and humans	16
Efficacy of nonpharmacological interventions for individual features of fibromyalgia: a systematic review and meta-analysis of randomised controlled trials	16
Amygdalar functional connectivity during resting and evoked pain in youth with functional abdominal pain disorders	16
Educational disparities in joint pain within and across US states: do macro sociopolitical contexts matter?	16
Leveraging value-based health principles to improve translation and impact of digital psychological interventions for people with chronic pain	16
Prediction of the response to repetitive transcranial magnetic stimulation of the motor cortex in peripheral neuropathic pain and validation of a new algorithm	16
Neuroinflammation drives sex-dependent effects on pain and negative affect in a murine model of repeated mild traumatic brain injury	16
Three dimensions of pain in osteoarthritis: development and validation of the Osteoarthritis Symptom Inventory Scale	16
In memoriam: Stephen B. McMahon, PhD, FMedSci December 21, 1954 to October 9, 2021	16
Advances in the analysis of intensive longitudinal pain data: a commentary on Leroux et al.	16
Effectiveness of neural mobilisation for the treatment of nerve-related cervicobrachial pain: a systematic review with subgroup meta-analysis	16

Canadian surveillance study of complex regional pain syndrome in children	16
Nerve injury induces transient locus coeruleus activation over time: role of the locus coeruleus–dorsal reticular nucleus pathway	15
Conotoxin contulakin-G engages a neurotensin receptor 2/R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception	15
Internet-delivered cognitive and behavioural based interventions for adults with chronic pain: a systematic review and meta-analysis of randomized controlled trials	15
Introduction to the biennial review of pain	15
Psychosocial mechanisms underlying the transition from acute to chronic postsurgical pain in youth following spinal fusion: a 6-month longitudinal study	15
Dorsal root ganglion toll-like receptor 4 signaling contributes to oxaliplatin-induced peripheral neuropathy	15
Resting-state electroencephalography and magnetoencephalography as biomarkers of chronic pain: a systematic review	15
A paraventricular hypothalamic nucleus input to ventral of lateral septal nucleus controls chronic visceral pain	15
MicroRNA let-7b enhances spinal cord nociceptive synaptic transmission and induces acute and persistent pain through neuronal and microglial signaling	15
Standardizing research methods for opioid dose comparison: the NIH HEAL morphine milligram equivalent calculator	15
Cutaneous nerve fiber and peripheral Nav1.7 assessment in a large cohort of patients with postherpetic neuralgia	15
A call to action to integrate best practice assessment of sexual orientation and gender identity in pain research and clinical care	14
TRPV1 is the burner	14
Gonadal hormone–dependent nociceptor sensitization maintains nociplastic pain state in female mice	14
A novel potential strategy for the treatment of inflammatory and neuropathic pain	14
Functioning in chronic pain: a call for a global definition	14
Neural mechanisms underlying the conditioned pain modulation response: a narrative review of neuroimaging studies	14
Comparing the prevalence of chronic pain in school-aged children in the United States from 2019 to 2020: a nationally representative study examining differences associated with the COVID-19 pandemic:	14
Where is the pain? Spatial patterns of pain co-occurrence in a population-based study of 4833 pain drawings incorporating network analysis	14
Reply to Manhapra	14
The local molecular signature of human peripheral neuropathic pain	14
Bodily maps of emotions and pain: tactile and hedonic sensitivity in healthy controls and patients experiencing chronic pain	14
Thermal grill illusion of pain in patients with chronic pain: a clinical marker of central sensitization?	14
Functional and anatomical analyses of active spinal circuits in a mouse model of chronic pain	14
Sympathetic modulation of tumor necrosis factor alpha-induced nociception in the presence of oral squamous cell carcinoma	14
The invisible cost of pain management by the current International Classification of Diseases coding system: a study in a tertiary care inpatient setting	14
Nociplastic pain—grading the unknown	14
Educational initiatives and achievements of the International Association for the Study of Pain	14
Reply to Ali	14
Reply to Moulton et al.	14
Unlocking the secrets of daily diary data: can we improve our understanding of the reinforcing effects of pain medication?	14
Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial	14
Body image, sex, gender, and pain: towards an improved understanding of pain mechanisms	14
Parental narrative style moderates the relation between pain-related attention and memory biases in youth with chronic pain	13
Clinical features and functional analysis of novel SCN9A variants causing congenital insensitivity to pain	13
Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes	13
Nucleus accumbens myocyte enhancer factor 2C mediates the maintenance of peripheral nerve injury–induced physiological and behavioral maladaptations	13
Predictive value of quantitative sensory testing for acute and chronic postsurgical pain after total joint arthroplasty: a systematic review	13
miR-1306-3p directly activates P2X3 receptors in primary sensory neurons to induce visceral pain in rats	13
Co-occurrence of chronic pain and anxiety/depression symptoms in U.S. adults: prevalence, functional impacts, and opportunities	13
Bilateral deficiency of Meissner corpuscles and papillary microvessels in patients with acute complex regional pain syndrome	13
A multicenter, randomized, double-blind, placebo-controlled, comparative study to evaluate the efficacy and safety of newly developed diclofenac patches in patients with cancer pain	13
Reply to Zhang and Pan	13
Measuring pain care quality in the Veterans Health Administration primary care setting	13
Recommendations for patient education in the management of persistent pelvic pain: a systematic review of clinical practice guidelines	13
Mast cell chymases: essential for preventing the transition from acute to chronic pain	13
Reply to Karlsen et al. Consensus on a core outcome set: a panel decision	13
Opioid-related risk perceptions in chronic pain: influence of patient gender and previous misuse behaviors	13
Perioperative factors associated with persistent postsurgical pain after hysterectomy, cesarean section, prostatectomy, and donor nephrectomy: a systematic review and meta-analysis	13
Oral squamous cell carcinoma–released brain-derived neurotrophic factor contributes to oral cancer pain by peripheral tropomyosin receptor kinase B activation	13
Effects of virtual reality on psychophysical measures of pain: superiority to imagination and nonimmersive conditions	13
Enhancing healthcare professionals' biopsychosocial perspective to chronic pain: assessing the impact of implementing an interdisciplinary training program	13
From SARS-CoV-2 to analgesia: harnessing the vascular endothelial growth factor A/neuropilin 1 axis for pain therapy	13
Impaired pain-related threat and safety learning in patients with chronic back pain	13
Mirror peripheral neuropathy and unilateral chronic neuropathic pain: insights from asymmetric neurological patterns in leprosy	12
Characterizing high-cost healthcare users among adults with back pain in Ontario, Canada: a population-based cohort study	12
Dorsal horn volume loss and pain pathway changes in Cavalier King Charles Spaniels with syringomyelia, signs of pain, and phantom scratching	12
Deciphering relationships between stress biomarkers and fibromyalgia syndrome with implications relevant to other chronic pain conditions	12
Haves and have-nots: socioeconomic position improves accuracy of machine learning algorithms for predicting high-impact chronic pain	12
CaV3.2 calcium channels contribute to trigeminal neuralgia	12
Reply to Esposto and Cioeta (2023): Clarification regarding classical conditioning and conditioned pain	12
Expectations underlie the effects of unpredictable pain: a behavioral and electroencephalogram study	12
Unbiased analysis of the dorsal root ganglion after peripheral nerve injury: no neuronal loss, no gliosis, but satellite glial cell plasticity	12
Brain predicted age in chronic pelvic pain: a study by the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network	12
Referred sensations in the orofacial region are associated with a decreased descending pain inhibition and modulated by remote noxious stimuli and local anesthesia	12
Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter p	12
Behavioral cancer pain intervention dosing: results of a Sequential Multiple Assignment Randomized Trial	12
A double-blind phase II randomized controlled trial of an online cognitive bias modification for interpretation program with and without psychoeducation for people with chronic pain	12
Serum levels of endocannabinoids and related lipids in painful vs painless diabetic neuropathy: results from the Pain in Neuropathy Study	12
A randomized-controlled pilot trial of telemedicine-delivered cognitive-behavioral therapy tailored for interstitial cystitis/bladder pain syndrome	12
Is blue light a red herring in a rodent model of “computer vision syndrome”?	12
Immunotherapy, a new approach for the treatment of human pain	12
Postnatal development of inner lamina II interneurons of the rat medullary dorsal horn	12
Reply to Blomqvist and Evrard	12
Elevated 18:0 lysophosphatidylcholine contributes to the development of pain in tissue injury	12
Descending mechanism by which medial prefrontal cortex endocannabinoid signaling controls the development of neuropathic pain and neuronal activity of dorsal root ganglion	12
Sleep disruption and activation of cellular inflammation mediate heightened pain sensitivity: a randomized clinical trial	12
Potentiation of visualized exosomal miR-1306-3p from primary sensory neurons contributes to chronic visceral pain via spinal P2X3 receptors	11
What is known and what is still unknown within chronic musculoskeletal pain? A systematic evidence and gap map	11
Psychiatric disorders, personality traits, and childhood traumatic events predicting incidence and persistence of chronic pain: results from the CoLaus|PsyCoLaus study	11
Rare variant analyses in large-scale cohorts identified SLC13A1 associated with chronic pain	11
Investigating neuroepigenetic alterations in chronic low back pain with positron emission tomography	11
Immigration background as a risk factor of chronic pain and high-impact chronic pain in children and adolescents living in Spain: differences as a function of age	11
Tyrosine kinase type A–specific signalling pathways are critical for mechanical allodynia development and bone alterations in a mouse model of rheumatoid arthritis	11
Long-term opioid therapy unsettles us both coming and going	11
Novel proresolving lipid mediator mimetic 3-oxa-PD1n-3 docosapentaenoic acid reduces acute and chronic itch by modulating excitatory and inhibitory synaptic transmission and astroglial secretion of li	11
Intensive interdisciplinary pain treatment for children and adolescents with chronic noncancer pain: a preregistered systematic review and individual patient data meta-analysis	11
Under the insula: a commentary on “Electrostimulation of the white matter of the posterior insula and medial operculum: perception of vibrations, heat, and pain”	11
A revisit of soreness and acidosis-related pain	11
Effect of prolonged experimental neck pain on exercise-induced hypoalgesia	11
Longitudinal examination of associations with the onset of pediatric chronic pain at different pain locations	11
Delphi study to explore a new diagnosis for “ineffective” long-term opioid therapy for chronic pain	11
Effects of combined chemotherapy and anti-programmed cell death protein 1 treatment on peripheral neuropathy and neuroinflammation in mice	11
Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain	11