Pain

Article	Citations
Chronic pain is specifically associated with updating working memory: a longitudinal twin study	212
Data-driven identification of distinct pain drawing patterns and their association with clinical and psychological factors: a study of 21,123 patients with spinal pain	119
Statistical modeling of acute and chronic pain patient-reported outcomes obtained from ecological momentary assessment	95
Adenosine causes short-lasting vasodilation and headache but not migraine attacks in migraine patients: a randomized clinical trial	84
Translational control by general control nonderepressible 2 kinase regulates methylglyoxal-induced pain in mice	82
The social nature of human pain	81
Automated detection of squint as a sensitive assay of sex-dependent calcitonin gene–related peptide and amylin-induced pain in mice	78
Neuropilin-1 is essential for vascular endothelial growth factor A–mediated increase of sensory neuron activity and development of pain-like behaviors	76
Sex differences in visceral sensitivity and brain activity in a rat model of comorbid pain: a longitudinal study	72
Intrinsic and synaptic properties of adult mouse spinoperiaqueductal gray neurons and the influence of neonatal tissue damage	72
On the adverse effects of gabapentinoids	67
Sex differences in facial expressions of pain: results from a combined sample	67
Validation of ICD-11 chronic pain severity specifiers for children and adolescents: an important step forward	64
White matter microstructural associations with pain experiences in a large community sample of youth	64
Unrelieved pain and risk of opioid use disorder or overdose in older adults prescribed opioids	62
Improving the art and science of communication in people living with chronic pain	60
Benign or painful? The interpretation of pain and fear of progression in rheumatoid arthritis	60
Vaso-occlusive crisis pain intensity, frequency, and duration: which best correlates with health-related quality of life in adolescents and adults with sickle cell disease?	52
Painful distortions: people with painful knee osteoarthritis have biased visuospatial perception of the environment	45
Description and initial validation of a novel measure of pain intensity: the Numeric Rating Scale of Underlying Pain without concurrent Analgesic use	44
Subjective salience ratings are a reliable proxy for physiological measures of arousal	43
Reply to dos Santos Ferreira and Velly	41
Innovative cognitive behavioral therapies for irritable bowel syndrome: processes, predictors, platforms, and outcomes	41
Reply to Quintner	41
Association between prescribed opioid dose and risk of motor vehicle crashes	40

Future perspectives: the next fifty years of the International Association for the Study of Pain	40
Pediatric chronic pain grading: a revised classification of the severity of pediatric chronic pain	39
Reply to Currie et al.	39
Personalised decision support in the management of patients with musculoskeletal pain in primary physiotherapy care: a cluster randomised controlled trial (the SupportPrim project)	38
Gut microbiota dysbiosis alters chronic pain behaviors in a humanized transgenic mouse model of sickle cell disease	37
Autoantibodies in patients with fibromyalgia syndrome	37
Widespread hyperexcitability of nociceptor somata outlasts enhanced avoidance behavior after incision injury	37
Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood: The HUNT Study	36
Diagnostic accuracy of quantitative sensory testing for detecting small fiber impairment in polyneuropathy and diagnosing small fiber neuropathy	35
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients	35
Gaining a new footing on molecular mechanisms of neuropathic pain in patients	34
Sex differences in pain expressed by patients across diverse disease states: individual patient data meta-analysis of 33,957 participants in 10 randomized controlled trials	34
Formation of perineuronal nets within a thalamocortical circuit shapes mechanical and thermal pain thresholds in mice with neuropathic pain	34
The impact of chronic pain on brain gene expression	33
Who develops chronic pain after an acute lower limb injury? A longitudinal study of children and adolescents	33
Decrease in pain perception during acute SARS-CoV-2 infection: a case series	32
Rejuvenation alleviates prolonged postsurgical pain in aging mice by mitigating inflammaging	31
Prevalence and correlates of “undiagnosed pain”—Evidence from the US national Medical Expenditure Panel Survey	31
Efficacy and safety of eliapixant in diabetic neuropathic pain and prediction of placebo responders with an exploratory novel algorithm: results from the randomized controlled phase 2a PUCCINI study	31
Opioid dose and pain effects of an online pain self-management program to augment usual care in adults with chronic pain: a multisite randomized clinical trial	30
TRESK background potassium channel regulates MrgprA3+ pruriceptor excitability, acute and chronic itch	30
Application of neurite orientation dispersion and density imaging in characterizing brain microstructural changes in classical trigeminal neuralgia and a comparison between the left and right sides	30
Reliability of quantitative sensory testing in the assessment of somatosensory function after high-frequency stimulation–induced sensitisation of central nociceptive pathways	30
Region-specific changes in brain glutamate and gamma-aminobutyric acid across the migraine attack in children and adolescents	30
Reply to Andrassy and Mukhdomi	30
Incidence of chronic pelvic pain after childbirth and its causal association with C-section	30
Multisite chronic pain as a causal risk factor for coronary artery disease: findings from Mendelian randomization	30
Dyspareunia: a novel clinical approach for diagnosis based on pain mechanisms	29
Astrocytogenic bidirectional plasticity at spinal nociceptive synapses regulates acute nociceptive processing	29
Thermal grill–induced pain: further evidence for its pathophysiological and clinical relevance	29
Progression trajectories of chronic overlapping pain conditions unveiled across two large clinical data warehouses	29
Association between physiotherapy utilization and medical healthcare utilization and costs in adults with back pain from Ontario, Canada: a population-based cohort study	29
Effect modifiers of virtual reality in pain management: a systematic review and meta-regression analysis	29
Paradoxical heat sensation as a manifestation of thermal hypesthesia: a study of 1090 patients with lesions of the somatosensory system: erratum	28
Can we improve patient outcomes through using evidence-based opioid deprescribing guidelines to reduce opioid use?	27
The biopsychosocial model of pain 40 years on: time for a reappraisal?	26
Commentary: social disparities in pain	26
Peripheral and central neurobiological effects of botulinum toxin A (BoNT/A) in neuropathic pain: a systematic review	26
Social support and the association between post-traumatic stress disorder and risk for long-term prescription opioid use	26
Adjunctive virtual reality pain relief after traumatic injury: a proof-of-concept within-person randomized trial	26
Alzheimer disease may compromise patients' ability for expectancy-based pain modulation. Now what?	26
Educational needs and preferences of adult patients with acute pain: a mixed-methods systematic review	25
Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus	25
Social integration of adolescents with chronic pain: a social network analysis	25
[11C]-PBR28 positron emission tomography signal as an imaging marker of joint inflammation in knee osteoarthritis	25
ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion	24
The association between parent mental health and pediatric chronic pain: a systematic review and meta-analysis	24
Increasing risk of cannabis use disorder among U.S. veterans with chronic pain: 2005-2019	24
Open data sharing: what could possibly go wrong?	24
A syngeneic inoculation mouse model of endometriosis that develops multiple comorbid visceral and cutaneous pain like behaviours	23

Neuroendocrine mechanisms in oxaliplatin-induced hyperalgesic priming	23
Converging inputs compete at the lateral parabrachial nuclei to dictate the affective-motivational responses to cold pain	23
Digging deeper into pain: an ethological behavior assay correlating well-being in mice with human pain experience	23
Assessing spontaneous sensory neuron activity using in vivo calcium imaging	23
Dose–response relationship and effect modifier of stabilisation exercises in nonspecific low back pain: a project-wide individual patient data re-analysis on 1483 intervention participants	23
Abdominoplasty as an acute postoperative pain model: insights from 8 years of clinical trials	23
Grpr expression defines a population of superficial dorsal horn vertical cells that have a role in both itch and pain	22
Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance: Erratum	22
Salivary metabolome indicates a shift in tyrosine metabolism in patients with burning mouth syndrome: a prospective case–control study	22
Resting-state occipital alpha power is associated with treatment outcome in patients with chronic migraine	22
A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology	21
Reply to Hoegh et al.	21
Renaming burning mouth syndrome: implications and use for the Research Diagnostic Criteria for Burning Mouth Syndrome	21
The thalamic projection of pain sensations to the posterior dorsal fundus in the insula: comment on Mandonnet et al.	21
Efficacy and safety of pharmacological, physical, and psychological interventions for the management of chronic pain in children: a WHO systematic review and meta-analysis: Erratum	21
Pain's puzzle pieces: MAGI-1, NaV1.8, degradation, analgesia	21
Delphi study to define core clinical outcomes for inclusion in a complex regional pain syndrome international research registry and data bank	21
Agreement between youth and caregiver report of pain and functioning in pediatric sickle cell disease: PedsQL sickle cell disease module	21
Pain relief after topical capsaicin: does it result from nociceptor degeneration or regeneration?	21
ATF4 inhibits TRPV4 function and controls itch perception in rodents and nonhuman primates	21
Interpretation bias and the transition from acute to chronic pain	20
Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception	20
Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort	20
Inequities in time-to-follow-up care and administrative action after low back pain diagnosis in active duty service members	20
Beyond the ambiguity of interpretation bias for pain-related information	20
Adding a nonpainful end to reduce pain recollection of Pap smear screening: a randomized controlled trial	20
Multi-omic integration with human dorsal root ganglia proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway	20
Patient preferences in the treatment of chronic musculoskeletal pain: a systematic review of discrete choice experiments	20
Standardizing research methods for opioid dose comparison: the NIH HEAL morphine milligram equivalent calculator	19
Chronic pain in European adult populations: a systematic review of prevalence and associated clinical features	19
Behavioral outcomes of complete Freund adjuvant–induced inflammatory pain in the rodent hind paw: a systematic review and meta-analysis	19
Cannabis use disorder in patients with chronic pain: overestimation and underestimation in a cross-sectional observational study in 3 German pain management centres	19
Effects of commonly used analgesics on sleep architecture: a topical review	19
Microneurographic portrait of 19 patients with small fiber neuropathy: a pilot study	19
MicroRNA let-7b enhances spinal cord nociceptive synaptic transmission and induces acute and persistent pain through neuronal and microglial signaling	18
Unraveling the puzzle of pain in pancreatic diseases	18
Internet-delivered cognitive and behavioural based interventions for adults with chronic pain: a systematic review and meta-analysis of randomized controlled trials	18
Huntington-associated protein 1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation	18
Multimodal hypersensitivity and somatic symptoms predict adolescent postmenarchal widespread pain	18
Rostral ventral medulla circuits regulate both the sensory and affective dimensions of neuropathic pain: a commentary on Dogrul et al.	18
Give and take: an evolutionary framework for social transactions in pain	18
Upregulation of LncRNA71132 in the spinal cord regulates hypersensitivity in a rat model of bone cancer pain	18
Amygdalar functional connectivity during resting and evoked pain in youth with functional abdominal pain disorders	18
Psychosocial mechanisms underlying the transition from acute to chronic postsurgical pain in youth following spinal fusion: a 6-month longitudinal study	18
Conotoxin contulakin-G engages a neurotensin receptor 2/R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception	18
Prediction of the response to repetitive transcranial magnetic stimulation of the motor cortex in peripheral neuropathic pain and validation of a new algorithm	18
Profiling the molecular signature of satellite glial cells at the single cell level reveals high similarities between rodents and humans	18
Accuracy of neuropathic pain measurements in patients with symptoms of polyneuropathy: validation of painDETECT, Self-Completed Leeds Assessment of Neuropathic Symptoms and Signs, and Douleur Neuropat	17
Estrous cycle regulates cephalic mechanical sensitivity and sensitization of the trigemino-cervical complex in a female rat model of chronic migraine	17
Chronic pain among U.S. sexual minority adults who identify as gay, lesbian, bisexual, or “something else”: Erratum	17
Interoception and pain: body–mind integration, rupture, and repair	17
A randomized, placebo-controlled trial of long-acting dexamethasone viscous gel delivered by transforaminal injection for lumbosacral radicular pain	17
“Belief-based” medicine is not evidence-based medicine	17
Informing about side effects: putting patients (preferences) first	17
CD304+ adipose tissue–derived mesenchymal stem cell abundance in autologous fat grafts highly correlates with improvement of localized pain syndromes	17
Chronic pain in the 11th Revision of the International Classification of Diseases: users' questions answered	17
Realigning the role of quantitative sensory testing in sensory profiling of patients with and without neuropathic pain	16
Three dimensions of pain in osteoarthritis: development and validation of the Osteoarthritis Symptom Inventory Scale	16
Demise of nociceptive Schwann cells causes nerve retraction and pain hyperalgesia: Erratum	16
Quantitative somatosensory testing of the abdomen: establishing initial reference values across developmental age and biological sex	16
Leveraging value-based health principles to improve translation and impact of digital psychological interventions for people with chronic pain	16
Melatonin for neuropathic pain: a double-blind, placebo-controlled, randomized, crossover trial	16
Is there really no association between postoperative opioid use and long-term surgical outcomes in patients diagnosed with liver cancer?	16
CARTp/GPR160 mediates behavioral hypersensitivities in mice through NOD2	16
Neuroinflammation drives sex-dependent effects on pain and negative affect in a murine model of repeated mild traumatic brain injury	16
Reply to Manhapra	16
In memoriam: Stephen B. McMahon, PhD, FMedSci December 21, 1954 to October 9, 2021	16
Advances in the analysis of intensive longitudinal pain data: a commentary on Leroux et al.	16
Biopsychosocial influence on shoulder pain: results from a randomized preclinical trial of exercise-induced muscle injury	16
Mechanisms and manifestations in musculoskeletal pain: from experimental to clinical pain settings	15
Effectiveness of neural mobilisation for the treatment of nerve-related cervicobrachial pain: a systematic review with subgroup meta-analysis	15
Thermal grill illusion of pain in patients with chronic pain: a clinical marker of central sensitization?	15
Predictors of response to full agonist opioids in enriched enrollment randomized withdrawal clinical trials: a participant-level data meta-analysis	15
Neural mechanisms underlying the conditioned pain modulation response: a narrative review of neuroimaging studies	15
The Canadian version of the National Institutes of Health minimum dataset for chronic low back pain research: reference values from the Quebec Low Back Pain Study	15
A paraventricular hypothalamic nucleus input to ventral of lateral septal nucleus controls chronic visceral pain	15
Resting-state electroencephalography and magnetoencephalography as biomarkers of chronic pain: a systematic review	15
Educational initiatives and achievements of the International Association for the Study of Pain	15
The “External Validity Crisis”: now is the time to address the attack on diversity, equity, and inclusion in pain science	15
TRPV1 is the burner	15

Cutaneous nerve fiber and peripheral Nav1.7 assessment in a large cohort of patients with postherpetic neuralgia	15
Educational disparities in joint pain within and across US states: do macro sociopolitical contexts matter?	15
Open-label nondeceptive placebo analgesia is blocked by the opioid antagonist naloxone	15
Functional and anatomical analyses of active spinal circuits in a mouse model of chronic pain	15
Deep learning–guided postoperative pain assessment in children	15
Contribution of S1pr1-featured astrocyte subpopulation to cisplatin-induced neuropathic pain in male mice	15
The associations of opioid and benzodiazepine prescriptions with injuries among US military service members	15
The thermal grill elicits central sensitization	14
Where is the pain? Spatial patterns of pain co-occurrence in a population-based study of 4833 pain drawings incorporating network analysis	14
Reply to Ali	14
Unlocking the secrets of daily diary data: can we improve our understanding of the reinforcing effects of pain medication?	14
Clinical features and functional analysis of novel SCN9A variants causing congenital insensitivity to pain	14
Nociplastic pain—grading the unknown	14
Reply to Moulton et al.	14
Reply to Manhapra	14
Functioning in chronic pain: a call for a global definition	14
A call to action to integrate best practice assessment of sexual orientation and gender identity in pain research and clinical care	14
A novel potential strategy for the treatment of inflammatory and neuropathic pain	14
Gonadal hormone–dependent nociceptor sensitization maintains nociplastic pain state in female mice	13
Effects of virtual reality on psychophysical measures of pain: superiority to imagination and nonimmersive conditions	13
Parental narrative style moderates the relation between pain-related attention and memory biases in youth with chronic pain	13
Sympathetic modulation of tumor necrosis factor alpha-induced nociception in the presence of oral squamous cell carcinoma	13
The local molecular signature of human peripheral neuropathic pain	13
Reliability and validity of the Pediatric PainSCAN: a screening tool for pediatric neuropathic pain and complex regional pain syndrome	13
Comparing the prevalence of chronic pain in school-aged children in the United States from 2019 to 2020: a nationally representative study examining differences associated with the COVID-19 pandemic:	13
Enhancing healthcare professionals' biopsychosocial perspective to chronic pain: assessing the impact of implementing an interdisciplinary training program	13
Bilateral deficiency of Meissner corpuscles and papillary microvessels in patients with acute complex regional pain syndrome	13
Nucleus accumbens myocyte enhancer factor 2C mediates the maintenance of peripheral nerve injury–induced physiological and behavioral maladaptations	13
Co-occurrence of chronic pain and anxiety/depression symptoms in U.S. adults: prevalence, functional impacts, and opportunities	13
Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes	13
Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial	13
Introduction to the biennial review of pain	13
Recommendations for patient education in the management of persistent pelvic pain: a systematic review of clinical practice guidelines	13
Body image, sex, gender, and pain: towards an improved understanding of pain mechanisms	13
The invisible cost of pain management by the current International Classification of Diseases coding system: a study in a tertiary care inpatient setting	13
Reply to Zhang and Pan	13
Bodily maps of emotions and pain: tactile and hedonic sensitivity in healthy controls and patients experiencing chronic pain	13
Behavioral cancer pain intervention dosing: results of a Sequential Multiple Assignment Randomized Trial	12
Selection of corticosteroids for epidural steroid injections	12
Mirror peripheral neuropathy and unilateral chronic neuropathic pain: insights from asymmetric neurological patterns in leprosy	12
Immunotherapy, a new approach for the treatment of human pain	12
Dorsal horn volume loss and pain pathway changes in Cavalier King Charles Spaniels with syringomyelia, signs of pain, and phantom scratching	12
Is blue light a red herring in a rodent model of “computer vision syndrome”?	12
TRPM3 as a novel target to alleviate acute oxaliplatin-induced peripheral neuropathic pain	12
Peripheral contributions to offset analgesia: effects of stimulus duration, intensity, and location	12
Mast cell chymases: essential for preventing the transition from acute to chronic pain	12
Expectations underlie the effects of unpredictable pain: a behavioral and electroencephalogram study	12
Potentiation of visualized exosomal miR-1306-3p from primary sensory neurons contributes to chronic visceral pain via spinal P2X3 receptors	12
Referred sensations in the orofacial region are associated with a decreased descending pain inhibition and modulated by remote noxious stimuli and local anesthesia	12
Haves and have-nots: socioeconomic position improves accuracy of machine learning algorithms for predicting high-impact chronic pain	12
From SARS-CoV-2 to analgesia: harnessing the vascular endothelial growth factor A/neuropilin 1 axis for pain therapy	12
Characterizing high-cost healthcare users among adults with back pain in Ontario, Canada: a population-based cohort study	12
A catheter-associated urinary tract infection mouse model to study bladder dysfunction and pain	12
Reply to Karlsen et al. Consensus on a core outcome set: a panel decision	12
Do “central sensitization” questionnaires reflect measures of nociceptive sensitization or psychological constructs? A systematic review and meta-analyses	12
Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter p	12
Reply to Esposto and Cioeta (2023): Clarification regarding classical conditioning and conditioned pain	12
Elevated 18:0 lysophosphatidylcholine contributes to the development of pain in tissue injury	12
miR-1306-3p directly activates P2X3 receptors in primary sensory neurons to induce visceral pain in rats	12
Reply to Blomqvist and Evrard	12
Descending mechanism by which medial prefrontal cortex endocannabinoid signaling controls the development of neuropathic pain and neuronal activity of dorsal root ganglion	12
Brain predicted age in chronic pelvic pain: a study by the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network	12
Patient engagement in pain research: no gain without the people in pain	12
Clinical improvements due to specific effects and placebo effects in conservative interventions and changes observed with no treatment in randomized controlled trials of patients with chronic nonspeci	12
Impaired pain-related threat and safety learning in patients with chronic back pain	12
Deciphering relationships between stress biomarkers and fibromyalgia syndrome with implications relevant to other chronic pain conditions	12
Editorial Board	12
Diagnosis of neuropathic pain in polyneuropathy: should screening questionnaires be thrown out?	11
Investigating neuroepigenetic alterations in chronic low back pain with positron emission tomography	11
Intensive interdisciplinary pain treatment for children and adolescents with chronic noncancer pain: a preregistered systematic review and individual patient data meta-analysis	11
Modulatory activity of N-palmitoyl-D-glucosamine in bridging gut dysbiosis and pain mechanisms	11
Serum levels of endocannabinoids and related lipids in painful vs painless diabetic neuropathy: results from the Pain in Neuropathy Study	11
The bidirectional relationship between sleep problems and chronic musculoskeletal pain: a systematic review with meta-analysis	11
The role of evolving concepts and new technologies and approaches in advancing pain research, management, and education since the establishment of the International Association for the Study of Pain	11
High-frequency electrical stimulation increases cortical excitability and mechanical sensitivity in a chronic large animal model	11
Novel proresolving lipid mediator mimetic 3-oxa-PD1n-3 docosapentaenoic acid reduces acute and chronic itch by modulating excitatory and inhibitory synaptic transmission and astroglial secretion of li	11
Longitudinal examination of associations with the onset of pediatric chronic pain at different pain locations	11
Randomized controlled trials of pain treatment: essential research tools, a framework for clinical care	11
Deep learning modelling of structural brain MRI in chronic head and neck pain after mild traumatic brain injury	11
Sleep disruption and activation of cellular inflammation mediate heightened pain sensitivity: a randomized clinical trial	11
Unbiased analysis of the dorsal root ganglion after peripheral nerve injury: no neuronal loss, no gliosis, but satellite glial cell plasticity	11
A randomized-controlled pilot trial of telemedicine-delivered cognitive-behavioral therapy tailored for interstitial cystitis/bladder pain syndrome	11
NaViGating arthritis pain	11
Rare variant analyses in large-scale cohorts identified SLC13A1 associated with chronic pain	11
Fifty years of pain research and clinical advances: highlights and key trends	11
Under the insula: a commentary on “Electrostimulation of the white matter of the posterior insula and medial operculum: perception of vibrations, heat, and pain”	11
A revisit of soreness and acidosis-related pain	11
CaV3.2 calcium channels contribute to trigeminal neuralgia	11
A double-blind phase II randomized controlled trial of an online cognitive bias modification for interpretation program with and without psychoeducation for people with chronic pain	11
Mechanisms of chronic pain in inflammatory rheumatism: the role of descending modulation	11
Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain	10
Tools for assessing labour pain: a comprehensive review of research literature	10
Reductions in kinesiophobia and distress after pain neuroscience education and exercise lead to favourable outcomes: a secondary mediation analysis of a randomized controlled trial in primary care	10
What is known and what is still unknown within chronic musculoskeletal pain? A systematic evidence and gap map	10
Allan Basbaum: third Editor-in-Chief of PAIN and finding joy in pain research	10