Clinical and Experimental Pharmacology and Physiology

Papers
(The median citation count of Clinical and Experimental Pharmacology and Physiology is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)
ArticleCitations
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Ulinastatin affects focal cerebral ischemia–reperfusion injury via SOCS1‐mediated JAK2/STAT3 signalling pathway45
Reliability of Matrix‐Assisted Laser Desorption‐Ionisation Time‐of‐Flight Mass Spectrometry as a Method for Drug‐Resistant Tuberculosis Gene Identification39
Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3‐mediated ZO‐1 expression33
Glycyrrhizic Acid Ameliorates LPS‐Induced WI‐38 Cell Inflammation, Oxidative Stress, and Ferroptosis via Targeting METTL14 in Infantile Pneumonia32
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Fibroblast growth factor 10 ameliorates renal ischaemia–reperfusion injury by attenuating mitochondrial damage31
Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells31
MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability30
LncRNA PRKCQ‐AS1 regulates paclitaxel resistance in triple‐negative breast cancer cells through miR‐361‐5p/PIK3C3 mediated autophagy27
Efficacy and safety of baricitinib for the treatment of moderate‐to‐severe atopic dermatitis: A systematic review and meta‐analysis of randomized clinical trials22
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Association between anti‐fibrillin‐2 protein induced retinal degeneration via intravitreous delivery and activated TGF‐β signalling in mice19
Weight‐based oxytocin infusion for preventing uterine atony during caesarean delivery in non‐labouring patients: A dose–response study19
Correction to “low‐intensity pulsed ultrasound prevents prolonged hypoxia‐induced cardiac fibrosis through HIF‐1α/DNMT3a pathway via a TRAAK‐dependent manner”18
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Development and Validation of a Comprehensive Risk Prediction Model for Polypoid Lesions of the Gallbladder18
The expected advantage of administering prophylactic antibiotics using target‐ concentration controlled infusion: Development of a new pharmacokinetic model of cefazolin18
Effects of a single dose of rocuronium in patients with different body fat percentages: A randomised controlled trial18
Cardioprotective effects of amiodarone in a rat model of epilepsy‐induced cardiac dysfunction17
Indole‐3‐Propionic Acid Improves Vascular Function in High‐Fat Diet‐Induced Obese Mice via eNOS16
SIRT1 targeted by miR‐211‐5p regulated proliferation and apoptosis of Dex‐treated growth plate chondrocytes via mediating SOX214
Corticosterone‐Induced Myocardial Dysfunctions and the Cardioprotective Role of Tauroursodeoxycholic Acid: An Experimental Study in Mice13
Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT213
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Pyroptosis‐Mediated Antitumor Activity of Cinobufagin in Non‐Small Cell Lung Cancer12
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ALKBH5 inhibits the SIRT3/ACC1 axis to regulate fatty acid metabolism via an m6A‐IGF2BP1‐dependent manner in cervical squamous cell carcinoma12
EZH2 promotes the progression of osteosarcoma through the activation of the AKT/GSK3β pathway12
Adrenalectomy attenuates hyperalgesia but does not regulate muscle wasting in a female rat model of fibromyalgia11
Pharmacological characterization of linzagolix, a novel, orally active, non‐peptide antagonist of gonadotropin‐releasing hormone receptors11
Protective effect of melatonin and ascorbic acid combination on sepsis‐induced lung injury: An Experimental study11
Effects of food on the pharmacokinetics of ensartinib in healthy Chinese subjects11
AEBP1 restores osteoblastic differentiation under dexamethasone treatment by activating PI3K/AKT signalling11
A single bout of exhaustive treadmill exercise increased AMPK activation associated with enhanced autophagy in mice skeletal muscle10
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Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression10
Bufalin reduces myocardial infarction‐induced myocardial fibrosis and improves cardiac function by inhibiting the NLRP3/IL‐1β signalling pathway10
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Angiotensin receptor‐neprilysin inhibitor attenuates cardiac hypertrophy and improves diastolic dysfunction in a mouse model of heart failure with preserved ejection fraction10
Rovatirelin ameliorates motor dysfunction in the cytosine arabinoside‐induced rat model of spinocerebellar degeneration via acetylcholine and dopamine neurotransmission10
Sex Steroid Control of Serotonergic System: Clinical Implications for Psychiatric Disorders and Addiction Treatment10
Rapid detection of guttae area using aniline blue staining in Fuchs endothelial corneal dystrophy mouse model9
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Erythropoietin hyporesponsiveness in non‐alcoholic fatty liver disease9
A spontaneous hyperglycaemic cynomolgus monkey presents cognitive deficits, neurological dysfunction and cataract9
Thioredoxin‐1 regulates the autophagy induced by oxidative stress through LC3‐II in human lens epithelial cells9
Artesunate alleviates psoriasis‐like dermatitis by reducing interleukin‐23 expression in tumor necrosis factor‐alpha‐induced HaCaT cells9
RETRACTION: Diosmetin Exerts Cardioprotective Effect on Myocardial Ischaemia Injury in Neonatal Rats by Decreasing Oxidative Stress and Myocardial Apoptosis9
GSK3β inhibitor TDZD8 ameliorates brain damage through both ROS scavenging and inhibition of apoptosis in hyperglycaemic subarachnoid haemorrhage rats9
TLR4 Inhibitor TAK‐242 Protected Henoch–Schonlein Purpura Nephritis in Rats by Regulating Inflammatory Response and Immune Competence via NFκB/NLRP3<9
Sevoflurane‐induced P300 promotes neuron apoptosis via Sp1/CDK9 pathway8
Therapeutic potential of curcumin in ARDS and COVID‐198
Nicorandil mitigates amiodarone‐induced pulmonary toxicity and fibrosis in association with the inhibition of lung TGF‐β1/PI3K/Akt1‐p/mTOR axis in rats8
Phosphatidylserine accelerates wound healing and reduces necrosis in the rats: Growth factor activation8
BCR::ABL1‐positive chronic myeloid leukaemia with CALR mutation8
Bromocriptine therapy: Review of mechanism of action, safety and tolerability8
Isoferulic Acid Inhibits Proliferation and Migration of Pancreatic Cancer Cells, and Promotes the Apoptosis of Pancreatic Cancer Cells in a Mitochondria‐Dependent Manner Through Inhibiting NF8
Possible involvement of apoptosis in the antipsychotics side effects: A mini‐review8
Electroacupuncture Attenuates Cerebral Ischemia–Reperfusion Injury by Inhibiting Ferroptosis via the p53/SLC7A11 Pathway8
Agomelatine alleviates steroid‐induced osteoporosis by targeting SIRT1/RANKL/FOXO1/OPG signalling in rats7
Tau and stathmin proteins in breast cancer: A potential therapeutic target7
Kaempferol Ameliorates Sepsis‐Acute Lung Injury by Promoting Succinylation of SRPK17
Global, Regional, and National Temporal Trend and Patterns of Change in the Burden of Asthma From 1990 to 2021: An Analysis of the Global Burden of Disease Study 20217
Metabolomic modelling and neuroprotective effects of carvacrol against acrylamide toxicity in rat's brain and sciatic nerve7
Prognostic value of inflammatory and nutritional indexes among advanced NSCLC patients receiving PD‐1 inhibitor therapy7
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Inhibition of mTOR by temsirolimus overcomes radio‐resistance in nasopharyngeal carcinoma7
Sirt6, Deubiquitinated and Stabilised by USP9X, Takes Essential Actions on the Pathogenesis of Experimental Autoimmune Myasthenia Gravis by Regulating CD4+ T Cells7
Esculentoside A ameliorates DNCB‐induced atopic dermatitis by suppressing the ROS‐NLRP3 axis via activating the Nrf2 pathway7
Hsa_circ_0001204 modulates inflammatory response of macrophages infected by Mycobacterium tuberculosis via TLR4/NF‐κB signalling pathway7
In vitro effects and mathematical modelling of CTCE‐9908 (a chemokine receptor 4 antagonist) on melanoma cell survival7
Hsa_circ_0097922 promotes tamoxifen resistance and cell malignant behaviour of breast cancer cells by regulating ACTN4 expression via miR‐876‐3p6
Comprehensive analysis of EphA2 in pan‐cancer: A prognostic biomarker associated with cancer immunity6
Whole‐exome sequencing‐based mutational profiling of hepatocellular adenoma malignant transformation to hepatocellular carcinoma6
Olfactory training for olfactory dysfunction in COVID‐19: A promising mitigation amidst looming neurocognitive sequelae of the pandemic6
Synergic actions of botulinum neurotoxin A and oxaliplatin on colorectal tumour cell death through the upregulation of TRPM2 channel‐mediated oxidative stress6
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Exosomal miR‐21‐5p derived from multiple myeloma cells promote renal epithelial–mesenchymal transition through targeting TGF‐β/SMAD7 signalling pathway6
Relationship between serum CHIP levels with cardiovascular disease in maintenance haemodialysis patients6
GLP‐1 receptor agonist liraglutide alleviates kidney injury by regulating nuclear translocation of NRF2 in diabetic nephropathy6
A 2‐week treatment with 5‐azacytidine improved the hypercontractility state in prostate from obese mice: Role of the nitric oxide‐cyclic guanosine monophosphate signalling pathway6
Overexpression of miR‐718 in Keratinocytes Affects the Psoriatic Inflammation via Targeting STAT1: In Vitro and In Vivo Evidence6
Scutellarin inhibits oleic acid induced vascular smooth muscle foam cell formation via activating autophagy and inhibiting NLRP3 inflammasome activation6
Propofol attenuates prostate cancer progression by upregulating TRHDEAS1 expression, and METTL14 could mediate its m6A modification6
Discovery of a chalcone derivative as potent necroptosis inhibitor for the treatment of acute kidney injury5
Impact of JAK/STAT inhibitors on human monocyte‐derived‐macrophages stimulated by cigarette smoke extract and lipopolysaccharide5
Palovarotene inhibits the NF‐κB signalling pathway to prevent heterotopic ossification5
Application of 3D computed tomography in emphysematous parenchyma patients scheduled for bronchoscopic lung volume reduction5
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Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats5
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Loganin exerts neuroprotective effect by inhibiting neuronal pyroptosis in rat with cerebral haemorrhage5
PD‐L1/PD‐L1 signalling promotes colorectal cancer cell migration ability through RAS/MEK/ERK5
Glaucocalyxin A induces apoptosis of non–small cell lung carcinoma cells by inhibiting the PI3K/Akt/GSK3β pathway5
Biochemical Investigation of the Association of Apolipoprotein E Gene Allele Variations with Insulin Resistance and Amyloid‐β Aggregation in Cardiovascular Disease5
Caffeic acid phenethyl ester ameliorates colistin‐induced nephrotoxicity in rats via modulation of FOXO1 /Nrf2/Sirt1 axis5
Shikonin ameliorates oxidative stress and neuroinflammation via the Akt/ERK/JNK/NF‐κB signalling pathways in a model of Parkinson's disease5
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Restoring Autophagy by Exercise Ameliorates Insulin Resistance Partly via Calcineurin‐Driven TFEB Nuclear Translocation5
Association between dietary inflammation index and inflammatory bowel disease in adults: Results from National Health and Nutrition Examination Survey 2009–20105
Study on the anti‐inflammatory effect of stachyose by inhibiting TLR4/NF‐κB signalling pathway in vitro and in vivo5
Dantrolene and ryanodine receptors in COVID‐19: The daunting task and neglected warden5
Pretreatment with nicotinamide mononucleotide increases the effect of ischaemic postconditioning on cardioprotection and mitochondrial function following ex vivo myocardial reperfusion injury in aged 5
Disk diffusion‐based method aids in the detection of vanM‐positive Enterococcus faecium with low vancomycin minimum inhibitory concentrations5
Growth hormone‐releasing hormone beyond cancer5
Linarin Relieves Apoptosis, Inflammation and Oxidative Stress in LPS‐Induced Acute Kidney Injury by Modulating COX25
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Endothelin System Blockade Extenuates Sepsis‐Induced Acute Heart and Kidney Injuries via Modulating ET‐1/Klotho/p38‐MAPK5
Potential roles of ellagic acid on metabolic variables in diabetes mellitus: A systematic review4
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Metabotropic glutamate receptor 5 blockade attenuates pathological cardiac remodelling in pulmonary arterial hypertension4
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Intravenous haloperidol and cocaine alter the distribution of T CD3+CD4+, non‐T/NK and NKT cells in rats4
Dihydromyricetin reverses capecitabine‐induced peripheral myelin dysfunction through modulation of oxidative stress4
Research trends in ferroptosis since the origin of the concept: A bibliometric analysis4
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Activation of GPR39 Ameliorates Placental Dysfunction by Inhibiting Activation of NLRP1 Inflammasome in Gestational Diabetes Mellitus4
Exploring the Protective Role and Regulation of Prdx6 in Cisplatin‐Induced AKI4
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Novel Semisynthetic Derivative of Dehydrozingerone (DHZ‐15) Modulates Lipopolysaccharide‐Stimulated Macrophages by Targeting the NFκB/p65 Pathway and In Vivo Evaluati4
Cancer‐associated fibroblast‐derived circFARP1 modulates non–small cell lung cancer invasion and metastasis through the circFARP1/miR‐338‐3p/SOX4 axis4
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Early and Stable Mouse Model of Amphotericin B‐Induced Acute Kidney Injury: Application of Continuous Non‐Invasive GFR Monitoring4
SMYD2 epigenetically activates MEX3A and suppresses CDX2 in colorectal cancer cells to augment cancer growth4
Synergistic effect of roflumilast with dexamethasone in a neutrophilic asthma mouse model4
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Zingerone stimulates osteoblast differentiation by increasing Smad1/5/9‐mediated HO‐1 expression in MC3T3‐E1 cells and primary mouse calvarial cells3
Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy3
Chronic intermittent hypoxia‐induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas3
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Angiotensin receptor blockade with olmesartan alleviates brain pathology in obese OLETF rats3
Anti‐prolactin treatment alleviates lupus conditions by regulating the JAK2STAT3 pathway3
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Mitochondrial Oxidative Stress and Cardiac Dysfunction in TERT Deficient Progeria Mice3
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A novel synthetised sulphonylhydrazone coumarin (E)‐4‐methyl‐N′‐(1‐(3‐oxo‐3H‐benzo[f]chromen‐2‐ yl)ethylidene)benzenesulphonohydrazide protect against isoproterenol‐induced myoca3
An evodiamine derivative inhibits osteoclast differentiation and protects against OVX‐induced bone loss in mice3
RuBPY decreases intracellular calcium by decreasing influx and increasing storage3
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NOTIFICATION: MiR‐375‐3p/YWHAZ/β‐catenin Axis Regulates Migration, Invasion, EMT in Gastric Cancer Cells3
Potential Kidney Risks Associated With Clinical Doses of Omeprazole: In Vivo and In Vitro Studies3
STAT5A modulated EndMT via upregulation of ELTD1 expression in diabetic nephropathy3
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IL‐4/STAT6 axis observed to reverse proliferative defect in SCA3 patient‐derived neural progenitor cells3
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PDZK1 Regulates the Stability and Function of ADRB2 to Prevent Vascular Remodelling in Hypertension3
The therapeutic effects and mechanisms of action of resveratrol on polycystic ovary syndrome: A comprehensive systematic review of clinical, animal and in vitro studies3
An analysis of antithrombotic therapy in elderly patients with atrial fibrillation undergoing percutaneous coronary interventions3
Brazilin inhibits bladder cancer by promoting cell necroptosis3
A gain of function ryanodine receptor 2 mutation (R1760W‐RyR2) in catecholaminergic polymorphic ventricular tachycardia3
Blockage of PD‐L1 by FERMT3‐mediated Wnt/β‐catenin signalling regulates chemoresistance and immune evasion of colorectal cancer cells3
MRGPRX2‐Mediated Mast Cell Degranulation by Monomethyl Methacrylate: Unveiling a Pathway in Bone Cement Implantation Syndrome3
Endothelin‐1 dependent expression of GAG genes involves NOX and p38 mediated Smad linker region phosphorylation3
Expression of Concern: High glucose facilitates cell cycle arrest of rat bone marrow multipotent adult progenitor cells through TGF‐β1 and ERK1/2 signaling without change in Oct‐4 expression3
Synthesis, Characterization, Molecular Dynamic Simulation and Neuroprotective Effects of Synthetic Isoxazolone Derivatives in Ethanol‐Induced Neurodegeneration3
Effect of phylloquinone on indomethacin‐induced gastric ulceration in rats: Role of SIRT‐13
Berberine interacts with gut microbiota and its potential therapy for polycystic ovary syndrome3
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Diclofenac Enhances the Response of BRAF Inhibitor to Melanoma Through ROS/p38/p53 Signaling3
Curcumol reduces lower limb arteriosclerosis in rats by inhibiting human arterial smooth muscle cell activity3
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U2AF1 mutation connects DNA damage to the alternative splicing of RAD51 in lung adenocarcinomas3
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Improved cardioprotective effect of 3‐nitro‐N‐methyl salicylamide solution after a prolonged preservation time of rat heart2
Colorectal cancer cells with stably expressed SIRT3 demonstrate proliferating retardation by Wnt/β‐catenin cascade inactivation2
Challenges with the proposed ACE2 activation mechanism of diminazene aceturate2
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Oroxin B Resembles Bisoprolol in Attenuating Beta1‐Adrenergic Receptor Autoantibody‐Induced Atrial Remodelling via the PTEN/AKT/mTOR Signalling Pathway2
Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification2
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A non‐antibiotic erythromycin derivative improves muscle endurance by regulating endogenous anti‐fatigue protein orosomucoid in mice2
Contribution of calcium dysregulation to impaired coronary artery contraction in Zucker diabetic fatty rats2
Inhibition of Hsp90 Alleviates Necroptosis and Inflammation in Lung Epithelial Cells During Pulmonary Ischemia–Reperfusion Injury2
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Dapagliflozin alleviates high glucose‐induced injury of endothelial cells via inducing autophagy2
NPAS2, transcriptionally activated by ARRB1, promotes the malignant behaviours of lung adenocarcinoma cells and regulates the reprogramming of glucose metabolism2
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Sinomenine Suppresses Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting O‐GlcNAcylation of SP12
Differential responses of cerebral and renal oxygenation to altered perfusion conditions during experimental cardiopulmonary bypass in sheep2
Trifolirhizin regulates the balance of Th17/Treg cells and inflammation in the ulcerative colitis mice through inhibiting the TXNIP‐mediated activation of NLRP3 inflammasome2
Extrinsic apoptosis and senescence involved in growth kinetics of seminoma to cisplatin2
Combining γ‐GT, PIVKA‐II, and AFP to predict long‐term prognosis in patients with hepatocellular carcinoma after hepatectomy2
Combination of SVI/S′ and diagnostic scores for heart failure with preserved ejection fraction2
Inosine monophosphate dehydrogenase activity and mycophenolate pharmacokinetics in children with nephrotic syndrome treated with mycophenolate mofetil2
Correction to “Glaucocalyxin A Induces Apoptosis of Non‐Small Cell Lung Carcinoma Cells by Inhibiting the PI3K/Akt/GSK3β Pathway”2
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3‐aminohydantoin derivate as a promising scaffold in dopaminergic neuroprotection and neurorescue in the in vivo and in vitro 6‐hydroxydopamine models of Parkinson's disease2
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Prophylactic Effects of Rhamnetin Flavonoid on Indomethacin‐Induced Gastric Ulceration by Modulating HSP 70/Bax, SOD/MDA and TNF‐α/IL‐102
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Clinical Analysis of Pulmonary Nontuberculous Mycobacterial Infection in Patients With Pre‐Existing Stage IIIV Lung Cancer2
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The Rough Morphotype of Mycobacterium abscessus Enhances Its Virulence Through ROS/p65/NLRP3/GSDMD‐Mediated Macrophage Pyroptosis2
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Anatomical Classification and Clinical Significance of Right Middle Lobe Vein Confluence Variations in Right Upper Lobectomy: A Three‐Dimensional Reconstruction Study2
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Limited sampling strategy to predict free mycophenolic acid area under the concentration–time curve in paediatric patients with nephrotic syndrome2
Cardioprotective potential of vanillic acid2
Dapagliflozin attenuates high glucose‐induced endothelial cell apoptosis and inflammation through AMPK/SIRT1 activation2
Bach1 modulates AKT3 transcription to participate in hyperglycaemia‐mediated EndMT in vascular endothelial cells2
β‐Carotene regulates glucose transport and insulin resistance in gestational diabetes mellitus by increasing the expression of SHBG2
Ligustrazine and liguzinediol protect against doxorubicin‐induced cardiomyocytes injury by inhibiting mitochondrial apoptosis and autophagy2
Frailty: An Important Determinant Influencing Glycaemic Control in Elderly Chinese Patients Diagnosed With Type 2 Diabetes2
PHD3‐Mediated Inhibition of Retinal Neovascularization in Retinopathy of Prematurity2
Ginsenoside Rh1 regulates gastric cancer cell biological behaviours and transplanted tumour growth in nude mice via the TGF‐β/Smad pathway2
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Uridine phosphorylase‐1 promotes cell viability and cell‐cycle progression in human epidermal keratinocytes via the glycolytic pathway2
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Kaempferol Suppresses Mesothelial–Mesenchymal Transition and Attenuates Postoperative Peritoneal Adhesions by Blocking the TNF‐α/COX2 Signalling Pathway2
Amnion membranes support wound granulation in a delayed murine excisional wound model2
Predictive Effect of FT3 Within the Euthyroid Range on LDL‐C in Patients With Type 2 Diabetes: A Cross‐Sectional Analysis of Inpatients in China2
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The Health Education During Root Canal Therapy Reduces the Use of Antibiotics1
A Novel Inhibitor of Methyltransferase SMYD2, AZ505 Protects Against Peritoneal Fibrosis in Mice1
Comparison of disease‐modifying anti‐rheumatic drugs and hyperbaric oxygen therapy in the experimental model of rheumatoid arthritis in rats1
Erythema induratum of Bazin after intravesical Bacillus Calmette‐Guérin immunotherapy1
Fingolimod Inhibits C6 Rat Glioma Proliferation and Migration, Induces Sub‐G1 Cell Cycle Arrest, Mitochondrial and Extrinsic Apoptosis In Vitro and Reduces Tumour Growth In Vivo1
The role and therapeutic applications of exosomes in multiple sclerosis disease1
Hemin mitigates contrast‐induced nephropathy by inhibiting ferroptosis viaHO‐1/Nrf2/GPX4pathway1
The ELF1 / IGF2BP2 / FAM111B Cascade Drives Col1
Hsa_circ_0000591 drives osteosarcoma glycolysis and progression by sequestering miR‐194‐5p and elevating HK2 expression1
D‐pinitol attenuates isoproterenol‐induced myocardial infarction by alleviating cardiac inflammation, oxidative stress and ultrastructural changes in Swiss albino mice1
Effects of polyphenols onncRNAsin cancer—An update1
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Epigallocatechin gallate for Parkinson's disease1
Stachydrine Protects Against Cyclophosphamide‐Induced Premature Ovarian Insufficiency in Wistar Rats by Inhibiting Oxidative Stress and Apoptosis via the Activation of the Nrf2/HO‐1 Signall1
Docosahexaenoic acid alleviates the excessive degradation of extracellular matrix in the nucleus pulposus by reducing the content of lncRNA NEAT1 to prevent the progression of intervertebra1
Kisspeptin‐10 Preserves the Blood‐Brain Barrier's Integrity Post‐Stroke by Augmenting Claudin‐10 Expression1
The effect of the protective face mask on cardiorespiratory response during aerobic exercise1
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Efficacy and safety of eptinezumab as preventive treatment for episodic/chronic migraine: A systematic review and meta‐analysis1
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Safety Evaluation of Nitroimidazole Antibiotics Based on the FAERS Database1
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CircADSS contributes to hepatocellular carcinoma development by regulating miR‐431‐5p/TOP2A1
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