Clinical and Experimental Pharmacology and Physiology

Article	Citations
Paracetamol – An old drug with new mechanisms of action	73
Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis	51
A role for retinoids in the treatment of COVID‐19?	51
LncRNA XIST promotes chemoresistance of breast cancer cells to doxorubicin by sponging miR‐200c‐3p to upregulate ANLN	39
A novel concept for treatment and vaccination against Covid‐19 with an inhaled chitosan‐coated DNA vaccine encoding a secreted spike protein portion	26
Empagliflozin alleviates ethanol‐induced cardiomyocyte injury through inhibition of mitochondrial apoptosis via a SIRT1/PTEN/Akt pathway	25
Targeting autophagy in neurodegenerative diseases: From molecular mechanisms to clinical therapeutics	24
The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases	23
MiR‐325‐3p inhibits renal inflammation and fibrosis by targeting CCL19 in diabetic nephropathy	22
Ginsenoside 20(S)‐Rg3 upregulates HIF‐1α‐targeting miR‐519a‐5p to inhibit the Warburg effect in ovarian cancer cells	21
Modulation of bleomycin‐induced oxidative stress and pulmonary fibrosis by N‐acetylcysteine in rats via AMPK/SIRT1/NF‐κβ	21
A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review	21
Berberine inhibits non‐small cell lung cancer cell growth through repressing DNA repair and replication rather than through apoptosis	19
Dapagliflozin attenuates high glucose‐induced endothelial cell apoptosis and inflammation through AMPK/SIRT1 activation	19
Immunoregulation by resveratrol; implications for normal tissue protection and tumour suppression	18
Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R/JAK/STAT augmentation in a rat model that mimics moderate and severe	18
Naringin promotes osteogenesis and ameliorates osteoporosis development by targeting JAK2/STAT3 signalling	18
Apigenin in cancer therapy: Prevention of genomic instability and anticancer mechanisms	18
Diagnostic and prognostic value of thymidylate synthase expression in breast cancer	18
Hantavirus diseases pathophysiology, their diagnostic strategies and therapeutic approaches: A review	17
Dihydroartemisinin attenuated the symptoms of mice model of systemic lupus erythematosus by restoring the Treg/Th17 balance	17
Serum uric acid and incident atrial fibrillation: A systematic review and dose–response meta‐analysis	16
Renal lipotoxicity: Insights from experimental models	16
Circ_0093887 upregulates CCND2 and SUCNR1 to inhibit the ox‐LDL‐induced endothelial dysfunction in atherosclerosis by functioning as a miR‐876‐3p sponge	16
ELABELA improves endothelial cell function via the ELA–APJ axis by activating the PI3K/Akt signalling pathway in HUVECs and EA.hy926 cells	16

Keratin 18 induces proliferation, migration, and invasion in gastric cancer via the MAPK signalling pathway	16
Alpha‐lipoic acid: A possible pharmacological agent for treating dry eye disease and retinopathy in diabetes	16
The JAK2 inhibitor AG490 regulates the Treg/Th17 balance and alleviates DSS‐induced intestinal damage in IBD rats	16
A comprehensive review on medicinal plants possessing antioxidant potential	15
Mechanisms of cancer stem cell senescence: Current understanding and future perspectives	15
Assessment of heavy metals by ICP‐OES and their impact on insulin stimulating hormone and carbohydrate metabolizing enzymes	15
Genetic and phenotypic frequency distribution of CYP2C9, CYP2C19 and CYP2D6 in over 3200 Han Chinese	14
Hydrogen sulphide attenuates neuronal apoptosis of substantia nigra by re‐establishing autophagic flux via promoting leptin signalling in a 6‐hydroxydopamine rat model of Parkinson's disease	14
Diosmetin exerts cardioprotective effect on myocardial ischaemia injury in neonatal rats by decreasing oxidative stress and myocardial apoptosis	14
Low‐intensity pulsed ultrasound prevents prolonged hypoxia‐induced cardiac fibrosis through HIF‐1α/DNMT3a pathway via a TRAAK‐dependent manner	14
Quercetin promotes locomotor function recovery and axonal regeneration through induction of autophagy after spinal cord injury	14
Bromocriptine therapy: Review of mechanism of action, safety and tolerability	14
Enhanced oxidative stress mediates pathological autophagy and necroptosis in cardiac myocytes in pressure overload induced heart failure in rats	14
Antihypertensive effect of carvacrol is improved after incorporation in β‐cyclodextrin as a drug delivery system	14
Mangiferin protect oxidative stress against deoxynivalenol induced damages through Nrf2 signalling pathways in endothelial cells	13
Dexmedetomidine attenuates one‐lung ventilation associated lung injury by suppressing inflammatory responses: A systematic review and meta‐analysis	13
Long non‐coding RNA DDX11‐AS1 promotes non‐small cell lung cancer development via regulating PI3K/AKT signalling	13
Transcription of CLDND1 in human brain endothelial cells is regulated by the myeloid zinc finger 1	13
The potential value of dequalinium chloride in the treatment of cancer: Focus on malignant glioma	13
Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model	13
The composite alliance of FTO locus with obesity‐related genetic variants	13
Tenacissoside H promotes neurological recovery of cerebral ischaemia/reperfusion injury in mice by modulating inflammation and oxidative stress via TrkB pathway	13
Administering crocin ameliorates anxiety‐like behaviours and reduces the inflammatory response in amyloid‐beta induced neurotoxicity in rat	13
Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats	13
Spirulina supplementation and oxidative stress and pro‐inflammatory biomarkers: A systematic review and meta‐analysis of controlled clinical trials	13
Melatonin and its derivative disrupt cancer stem‐like phenotypes of lung cancer cells via AKT downregulation	12
Glucagon‐like peptide‐1 receptor agonist treatment of high carbohydrate intake‐induced metabolic syndrome provides pleiotropic effects on cardiac dysfunction through alleviations in electrical and int	12
Acute hypotensive effect of diminazene aceturate in spontaneously hypertensive rats: role of NO and Mas receptor	12
Expressions of m6A RNA methylation regulators and their clinical predictive value in cervical squamous cell carcinoma and endometrial adenocarcinoma	12
Roxadustat (FG‐4592) protects against ischaemia/reperfusion‐induced acute kidney injury through inhibiting the mitochondrial damage pathway in mice	12
The dual orexin receptor antagonist daridorexant does not affect the pharmacokinetics of the BCRP substrate rosuvastatin	12
Cross‐sex testosterone therapy modifies the renal morphology and function in female rats and might underlie increased systolic pressure	11
Cardioprotective potential of vanillic acid	11
Donepezil down‐regulates propionylation, 2‐hydroxyisobutyrylation, butyrylation, succinylation, and crotonylation in the brain of bilateral common carotid artery occlusion‐induced vascular dementia ra	11
Taurine prevents high‐fat diet‐induced‐hepatic steatosis in rats by direct inhibition of hepatic sterol regulatory element‐binding proteins and activation of AMPK	11
Long non‐coding RNA H19 promotes myoblast fibrogenesis via regulating the miR‐20a‐5p‐Tgfbr2 axis	11
Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats	11
Association between periodontitis and hyperlipidaemia: A systematic review and meta‐analysis	11
Cell and extracellular matrix interaction models in benign mesothelial and malignant pleural mesothelioma cells in 2D and 3D in‐vitro	11
Sodium butyrate ameliorates non‐alcoholic fatty liver disease by upregulating miR‐150 to suppress CXCR4 expression	11
Chrysophanol increases osteoblast differentiation via AMPK/Smad1/5/9 phosphorylation in vitro and in vivo	11
Effect of orexin‐A on mitochondrial biogenesis, mitophagy and structure in HEK293‐APPSWE cell model of Alzheimer's disease	10
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF‐β1/Smads and NFκB pathways	10
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation	10
Antibody‐mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload	10
Liraglutide improves obesity‐induced renal injury by alleviating uncoupling of the glomerular VEGF–NO axis in obese mice	10
The effects of mirabegron on obesity‐induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue	10
Dysfunction of perivascular adipose tissue in mesenteric artery is restored by aerobic exercise in high‐fat diet induced obesity	10
The anti‐tumourigenic effect of ellagic acid in SKOV‐3 ovarian cancer cells entails activation of autophagy mediated by inhibiting Akt and activating AMPK	10
Biochemical investigation of rs1801282 variations in PPAR‐γ gene and its correlation with risk factors of diabetes mellitus in coronary artery disease	10

The pivotal relation between glucagon‐like peptides, NFκB and inflammatory bowel disease	10
Cerebral palsy: Aetiology, pathophysiology and therapeutic interventions	10
Resveratrol suppresses cholestasis‐induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1–Smad3–miR21 axis and profibrogenic and hepatic injury biomarkers	10
An update of genetics, co‐morbidities and management of hyperuricaemia	10
Curcumin‐coated gold nanoparticles attenuate doxorubicin‐induced cardiotoxicity via regulating apoptosis in a mouse model	10
The association between serum albumin/prealbumin level and disease severity in non‐CF bronchiectasis	9
Dapagliflozin and xanthine oxidase inhibitors improve insulin resistance and modulate renal glucose and urate transport in metabolic syndrome	9
Intra‐operative and early post‐operative prediction of cardiac surgery‐associated acute kidney injury: Urinary oxygen tension compared with plasma and urinary biomarkers	9
Role of the SphK‐S1P‐S1PRs pathway in invasion of the nervous system by SARS‐CoV‐2 infection	9
Prognostic value of inflammatory and nutritional indexes among advanced NSCLC patients receiving PD‐1 inhibitor therapy	9
Toll‐like receptor‐2 mediates systemic inflammation in gentamicin‐induced rat nephrotoxicity	9
Salvianolic acid A blocks vasculogenic mimicry formation in human non‐small cell lung cancer via PI3K/Akt/mTOR signalling	9
Salidroside protects against diabetes mellitus‐induced kidney injury and renal fibrosis by attenuating TGF‐β1 and Wnt1/3a/β‐catenin signalling	9
Olfactory training for olfactory dysfunction in COVID‐19: A promising mitigation amidst looming neurocognitive sequelae of the pandemic	9
Solamargine induces autophagy‐mediated apoptosis and enhances bortezomib activity in multiple myeloma	9
The nicotinamide phosphoribosyltransferase antagonist FK866 inhibits growth of prostate tumour spheroids and increases doxorubicin retention without changes in drug transporter and cancer stem cell pr	9
Enhanced oral bioavailability and biodistribution of atractylodin encapsulated in PLGA nanoparticle in cholangiocarcinoma	9
Signalling pathway of U46619‐induced vascular smooth muscle contraction in mouse coronary artery	9
Characterization of B cell‐mediated PD‐1/PD‐L1 interaction in pancreatic cancer patients	9
TPPP3 inhibits the proliferation, invasion and migration of endometrial carcinoma targeted with miR‐1827	9
Hypothesis: The potential therapeutic role of nicorandil in COVID‐19	9
Nebivolol protects against cyclophosphamide‐induced nephrotoxicity through modulation of oxidative stress, inflammation, and apoptosis	9
The effect of the protective face mask on cardiorespiratory response during aerobic exercise	8
Cardiac abnormalities after induction of endoplasmic reticulum stress are associated with mitochondrial dysfunction and connexin43 expression	8
Hesperidin inhibits L‐NAME‐induced vascular and renal alterations in rats by suppressing the renin–angiotensin system, transforming growth factor‐β1, and oxidative stress	8
The RNA N6‐methyladenosine modulator HNRNPA2B1 is involved in the development of non‐small cell lung cancer	8
Dipeptidyl peptidase 4 inhibitors attenuate cardiac ischaemia–reperfusion injury in rats with diabetes mellitus type 2	8
Omega‐3 polyunsaturated fatty acids in the treatment of non‐alcoholic fatty liver disease: An umbrella systematic review and meta‐analysis	8
Long noncoding RNAs: Important participants and potential therapeutic targets for myocardial ischaemia reperfusion injury	8
Sildenafil attenuates nonsteroidal anti‐inflammatory‐induced gastric ulceration in mice via antioxidant and antigenotoxic mechanisms	8
The therapeutic effects and mechanisms of action of resveratrol on polycystic ovary syndrome: A comprehensive systematic review of clinical, animal and in vitro studies	8
Therapeutic potential of curcumin in ARDS and COVID‐19	8
Renal water conservation and the volume kinetics of fluid‐induced diuresis: A retrospective analysis of two cohorts of elderly men	8
Thymoquinone attenuates isoproterenol‐induced myocardial infarction by inhibiting cytochrome C and matrix metalloproteinase‐9 expression	8
Hemin mitigates contrast‐induced nephropathy by inhibiting ferroptosis via HO‐1/Nrf2/GPX4 pathway	8
Transcription factor EB enhances autophagy and ameliorates palmitate‐induced insulin resistance at least partly via upregulating AMPK activity in skeletal muscle cells	7
Pharmacological characterization of linzagolix, a novel, orally active, non‐peptide antagonist of gonadotropin‐releasing hormone receptors	7
Shikonin ameliorates oxidative stress and neuroinflammation via the Akt/ERK/JNK/NF‐κB signalling pathways in a model of Parkinson's disease	7
Rotenone restrains the proliferation, motility and epithelial–mesenchymal transition of colon cancer cells and the tumourigenesis in nude mice via PI3K/AKT pathway	7
Potential of crocodile blood as a medication and dietary supplement: A systemic review	7
Propofol suppresses cell proliferation in gastric cancer cells through NRF2‐mediated polyol pathway	7
Epigallocatechin gallate for Parkinson's disease	7
Effects of polyphenols onncRNAsin cancer—An update	7
Policosanol attenuates Pi‐induced calcification via AMPK‐mediated INSIGs expression in rat VSMCs	7
LPS preconditioning of MSC‐CM improves protection against hypoxia/reoxygenation‐induced damage in H9c2 cells partly via HMGB1/Bach1 signalling	7
LncRNA PRKCQ‐AS1 regulates paclitaxel resistance in triple‐negative breast cancer cells through miR‐361‐5p/PIK3C3 mediated autophagy	7
Circ_0017274 acts on miR‐637/CDX2 axis to facilitate cisplatin resistance in gastric cancer	6
Thymoquinone chemosensitizes human colorectal cancer cells to imatinib via uptake/efflux genes modulation	6
The use of Ca‐transient to evaluate Ca2+ utilization by myofilaments in living cardiac muscle	6
Reversible bronchial dilatation in adults	6
Effect of papaverine on developmental hyperserotonemia induced autism spectrum disorder related behavioural phenotypes by altering markers of neuronal function, inflammation, and oxidative stress in r	6
Klotho inhibits H2O2‐induced oxidative stress and apoptosis in periodontal ligament stem cells by regulating UCP2 expression	6
SS‐31 protect retinal pigment epithelial cells from H2O2‐induced cell injury by reducing apoptosis	6
Synthesis, characterization, biological activity and electrochemistry studies of iron(III) complex with curcumin‐oxime ligand	6
Discovery of a chalcone derivative as potent necroptosis inhibitor for the treatment of acute kidney injury	6
The sphingosine‐1‐phosphate receptor modulator, FTY720, prevents the incidence of diabetes in Spontaneously Diabetic Torii rats	6
Renal functional recovery among inpatients: A plausible marker of reduced renal functional reserve	6
Nalbuphine on postoperative gastrointestinal tract dysfunction after laparoscopic surgery for gynaecological malignancies: A randomized controlled trial	6
Cold‐inflammaging: When a state of homeostatic‐imbalance associated with aging precedes the low‐grade pro‐inflammatory‐state (inflammaging): Meaning, evolution, inflammaging phenotypes	6
Dantrolene and ryanodine receptors in COVID‐19: The daunting task and neglected warden	6
Renalase—A new understanding of its enzymatic and non‐enzymatic activity and its implications for future research	6
Sucralose causes non‐selective CD4 and CD8 lymphotoxicity via probable regulation of the MAPK8/APTX/EID1 genes: An in vitro/in silico study	6
Rosuvastatin and low‐dose carvedilol combination protects against isoprenaline‐induced myocardial infarction in rats: Role of PI3K/Akt/Nrf2/HO‐1 signalling	6
Pharmacological characterization of the chronic phase of the monoiodoacetate‐induced rat model of osteoarthritis pain in the knee joint	6
DNA methylation determines the regulation of pregnane X receptor on CYP3A4 expression	6
1,25‐dihydroxyvitamin D3 prevents deleterious effects of erythromycin on mitochondrial function in rat heart isolated mitochondria	6
Circulating levels of hydrogen sulphide negatively correlate to nitrite levels in gestational hypertensive and preeclamptic pregnant women	6
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats	6
Rosmarinic acid protects against lipopolysaccharide‐induced cardiac dysfunction via activating Sirt1/PGC‐1α pathway to alleviate mitochondrial impairment	5
Evidence for altered insulin signalling in the brains of genetic absence epilepsy rats from Strasbourg	5
PD‐L1/PD‐L1 signalling promotes colorectal cancer cell migration ability through RAS/MEK/ERK	5
Blockage of PD‐L1 by FERMT3‐mediated Wnt/β‐catenin signalling regulates chemoresistance and immune evasion of colorectal cancer cells	5
Effects of obesity and diabesity on heart rhythm in the Zucker rat	5
Astaxanthin extenuates the inhibition of aldehyde dehydrogenase and Klotho protein expression in cyclophosphamide‐induced acute cardiomyopathic rat model	5
The circular RNA circ_GRHPR promotes NSCLC cell proliferation and invasion via interactions with the RNA‐binding protein PCBP2	5
Methyltransferase‐like 3 promotes the progression of lung cancer via activating PI3K/AKT/mTOR pathway	5
Therapeutic potential of targeted‐gold nanospheres on collagen‐induced arthritis in rats	5
Comparative effectiveness of Lopinavir/Ritonavir‐based regimens in COVID‐19	5
Trifolirhizin regulates the balance of Th17/Treg cells and inflammation in the ulcerative colitis mice through inhibiting the TXNIP‐mediated activation of NLRP3 inflammasome	5
The efficacy of soy isoflavones combined with soy protein on serum concentration of interleukin‐6 and tumour necrosis factor‐α among post‐menopausal women? A systematic review and meta‐analysis of ran	5

ALKBH5 inhibits the SIRT3/ACC1 axis to regulate fatty acid metabolism via an m6A‐IGF2BP1‐dependent manner in cervical squamous cell carcinoma	5
Efficacy and safety of baricitinib for the treatment of moderate‐to‐severe atopic dermatitis: A systematic review and meta‐analysis of randomized clinical trials	5
Reversion of cardiovascular remodelling in renovascular hypertensive 2K‐1C rats by renin–angiotensin system inhibitors	5
Inhibition of sphingosine 1‐phosphate (S1P) receptor 1/2/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast‐like synoviocyte MH7A cells through Gαi/Gαs rebalancing	5
Neuroprotective effect of roflumilast under cerebral ischaemia/reperfusion injury in juvenile rats through NLRP‐mediated inflammatory response inhibition	5
Perivascular adipose tissue and microvascular endothelial dysfunction in obese mice: Beneficial effects of aerobic exercise in adiponectin receptor (AdipoR1) and peNOSSer1177	5
Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression	5
Decreased autophagy of vascular smooth muscle cells was involved in hyperhomocysteinemia‐induced vascular ageing	5
Associations between peripheral perfusion disorders, mean arterial pressure and dose of norepinephrine administrated in the early phase of septic shock	5
Myrtenol complexed with β‐cyclodextrin ameliorates behavioural deficits and reduces oxidative stress in the reserpine‐induced animal model of Parkinsonism	5
High‐sucrose diet potentiates hyperaldosteronism and renal injury induced by stress in young adult rats	5
Association of natriuretic peptide and adverse outcomes in patients with atrial fibrillation: A meta‐analysis	5
Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur, and Han Chinese populations	5
ARHGAP17 inhibits pathological cyclic strain‐induced apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42	5
Resolvin D1 prevents cadmium chloride‐induced memory loss and hippocampal damage in rats by activation/upregulation of PTEN‐induced suppression of PI3K/Akt/mTOR signaling pathway	5
Metabolomics reveal dynamic changes in eicosanoid profile in patients with ST‐elevation myocardial infarction after percutaneous coronary intervention	5
Immunodepression induced by influenza A virus (H1N1) in lymphoid organs functions as a pathogenic mechanism	5
Protective effect of melatonin and ascorbic acid combination on sepsis‐induced lung injury: An Experimental study	5