OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Experimental Pharmacology and Physiology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
	45
Ulinastatin affects focal cerebral ischemia–reperfusion injury via SOCS1‐mediated JAK2/STAT3 signalling pathway	44
MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability	37
Glycyrrhizic Acid Ameliorates LPS‐Induced WI‐38 Cell Inflammation, Oxidative Stress, and Ferroptosis via Targeting METTL14 in Infantile Pneumonia	32
Issue Information	31
Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells	31
Efficacy and safety of baricitinib for the treatment of moderate‐to‐severe atopic dermatitis: A systematic review and meta‐analysis of randomized clinical trials	31
Fibroblast growth factor 10 ameliorates renal ischaemia–reperfusion injury by attenuating mitochondrial damage	30
The RNA N⁶‐methyladenosine modulator HNRNPA2B1 is involved in the development of non‐small cell lung cancer	29
LncRNA PRKCQ‐AS1 regulates paclitaxel resistance in triple‐negative breast cancer cells through miR‐361‐5p/PIK3C3 mediated autophagy	27
Reliability of Matrix‐Assisted Laser Desorption‐Ionisation Time‐of‐Flight Mass Spectrometry as a Method for Drug‐Resistant Tuberculosis Gene Identification	21
Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3‐mediated ZO‐1 expression	21
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Weight‐based oxytocin infusion for preventing uterine atony during caesarean delivery in non‐labouring patients: A dose–response study	19
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Prefrontal cortex pyramidal neurons express functional Nav1.8 tetrodotoxin‐resistant sodium currents	18
Association between anti‐fibrillin‐2 protein induced retinal degeneration via intravitreous delivery and activated TGF‐β signalling in mice	18
The expected advantage of administering prophylactic antibiotics using target‐ concentration controlled infusion: Development of a new pharmacokinetic model of cefazolin	18
Effects of a single dose of rocuronium in patients with different body fat percentages: A randomised controlled trial	17
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Correction to “low‐intensity pulsed ultrasound prevents prolonged hypoxia‐induced cardiac fibrosis through HIF‐1α/DNMT3a pathway via a TRAAK‐dependent manner”	16
Development and Validation of a Comprehensive Risk Prediction Model for Polypoid Lesions of the Gallbladder	16
Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2	14
Cardioprotective effects of amiodarone in a rat model of epilepsy‐induced cardiac dysfunction	14
Indole‐3‐Propionic Acid Improves Vascular Function in High‐Fat Diet‐Induced Obese Mice via eNOS	13

ALKBH5 inhibits the SIRT3/ACC1 axis to regulate fatty acid metabolism via an m6A‐IGF2BP1‐dependent manner in cervical squamous cell carcinoma	12
A single bout of exhaustive treadmill exercise increased AMPK activation associated with enhanced autophagy in mice skeletal muscle	12
SIRT1 targeted by miR‐211‐5p regulated proliferation and apoptosis of Dex‐treated growth plate chondrocytes via mediating SOX2	12
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Corticosterone‐Induced Myocardial Dysfunctions and the Cardioprotective Role of Tauroursodeoxycholic Acid: An Experimental Study in Mice	12
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Protective effect of melatonin and ascorbic acid combination on sepsis‐induced lung injury: An Experimental study	11
Issue Information	11
Pyroptosis‐Mediated Antitumor Activity of Cinobufagin in Non‐Small Cell Lung Cancer	11
AEBP1 restores osteoblastic differentiation under dexamethasone treatment by activating PI3K/AKT signalling	11
EZH2 promotes the progression of osteosarcoma through the activation of the AKT/GSK3β pathway	11
Issue Information	11
Bufalin reduces myocardial infarction‐induced myocardial fibrosis and improves cardiac function by inhibiting the NLRP3/IL‐1β signalling pathway	10
Pharmacological characterization of linzagolix, a novel, orally active, non‐peptide antagonist of gonadotropin‐releasing hormone receptors	10
Thioredoxin‐1 regulates the autophagy induced by oxidative stress through LC3‐II in human lens epithelial cells	10
Adrenalectomy attenuates hyperalgesia but does not regulate muscle wasting in a female rat model of fibromyalgia	10
Rovatirelin ameliorates motor dysfunction in the cytosine arabinoside‐induced rat model of spinocerebellar degeneration via acetylcholine and dopamine neurotransmission	10
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Propofol suppresses cell proliferation in gastric cancer cells through NRF2‐mediated polyol pathway	10
Effects of food on the pharmacokinetics of ensartinib in healthy Chinese subjects	10
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GSK3β inhibitor TDZD8 ameliorates brain damage through both ROS scavenging and inhibition of apoptosis in hyperglycaemic subarachnoid haemorrhage rats	9
TLR4 Inhibitor TAK‐242 Protected Henoch–Schonlein Purpura Nephritis in Rats by Regulating Inflammatory Response and Immune Competence via NF‐ κB/NLRP3<	9
RETRACTION: Diosmetin Exerts Cardioprotective Effect on Myocardial Ischaemia Injury in Neonatal Rats by Decreasing Oxidative Stress and Myocardial Apoptosis	9
Sex Steroid Control of Serotonergic System: Clinical Implications for Psychiatric Disorders and Addiction Treatment	9
Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression	9
Erythropoietin hyporesponsiveness in non‐alcoholic fatty liver disease	9
Angiotensin receptor‐neprilysin inhibitor attenuates cardiac hypertrophy and improves diastolic dysfunction in a mouse model of heart failure with preserved ejection fraction	9
Artesunate alleviates psoriasis‐like dermatitis by reducing interleukin‐23 expression in tumor necrosis factor‐alpha‐induced HaCaT cells	9
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Rapid detection of guttae area using aniline blue staining in Fuchs endothelial corneal dystrophy mouse model	8
Prognostic value of inflammatory and nutritional indexes among advanced NSCLC patients receiving PD‐1 inhibitor therapy	8
Therapeutic potential of curcumin in ARDS and COVID‐19	8
Isoferulic Acid Inhibits Proliferation and Migration of Pancreatic Cancer Cells, and Promotes the Apoptosis of Pancreatic Cancer Cells in a Mitochondria‐Dependent Manner Through Inhibiting NF	8
Sevoflurane‐induced P300 promotes neuron apoptosis via Sp1/CDK9 pathway	8
A spontaneous hyperglycaemic cynomolgus monkey presents cognitive deficits, neurological dysfunction and cataract	8
Nicorandil mitigates amiodarone‐induced pulmonary toxicity and fibrosis in association with the inhibition of lung TGF‐β1/PI3K/Akt1‐p/mTOR axis in rats	8
BCR::ABL1‐positive chronic myeloid leukaemia with CALR mutation	8
Bromocriptine therapy: Review of mechanism of action, safety and tolerability	7
Electroacupuncture Attenuates Cerebral Ischemia–Reperfusion Injury by Inhibiting Ferroptosis via the p53/SLC7A11 Pathway	7
Hsa_circ_0001204 modulates inflammatory response of macrophages infected by Mycobacterium tuberculosis via TLR4/NF‐κB signalling pathway	7
Agomelatine alleviates steroid‐induced osteoporosis by targeting SIRT1/RANKL/FOXO1/OPG signalling in rats	7
Phosphatidylserine accelerates wound healing and reduces necrosis in the rats: Growth factor activation	7
Esculentoside A ameliorates DNCB‐induced atopic dermatitis by suppressing the ROS‐NLRP3 axis via activating the Nrf2 pathway	7
Kaempferol Ameliorates Sepsis‐Acute Lung Injury by Promoting Succinylation of SRPK1	7
Metabolomic modelling and neuroprotective effects of carvacrol against acrylamide toxicity in rat's brain and sciatic nerve	7
Possible involvement of apoptosis in the antipsychotics side effects: A mini‐review	7
Tau and stathmin proteins in breast cancer: A potential therapeutic target	7
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Issue Information	7
Sirt6, Deubiquitinated and Stabilised by USP9X, Takes Essential Actions on the Pathogenesis of Experimental Autoimmune Myasthenia Gravis by Regulating CD4⁺ T Cells	6
Issue Information	6
Overexpression of miR‐718 in Keratinocytes Affects the Psoriatic Inflammation via Targeting STAT1: In Vitro and In Vivo Evidence	6
Inhibition of mTOR by temsirolimus overcomes radio‐resistance in nasopharyngeal carcinoma	6
Global, Regional, and National Temporal Trend and Patterns of Change in the Burden of Asthma From 1990 to 2021: An Analysis of the Global Burden of Disease Study 2021	6
Issue Information	6
Relationship between serum CHIP levels with cardiovascular disease in maintenance haemodialysis patients	6
Scutellarin inhibits oleic acid induced vascular smooth muscle foam cell formation via activating autophagy and inhibiting NLRP3 inflammasome activation	6
Hsa_circ_0097922 promotes tamoxifen resistance and cell malignant behaviour of breast cancer cells by regulating ACTN4 expression via miR‐876‐3p	6
In vitro effects and mathematical modelling of CTCE‐9908 (a chemokine receptor 4 antagonist) on melanoma cell survival	6
GLP‐1 receptor agonist liraglutide alleviates kidney injury by regulating nuclear translocation of NRF2 in diabetic nephropathy	6
Discovery of a chalcone derivative as potent necroptosis inhibitor for the treatment of acute kidney injury	5
Exosomal miR‐21‐5p derived from multiple myeloma cells promote renal epithelial–mesenchymal transition through targeting TGF‐β/SMAD7 signalling pathway	5
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Linarin Relieves Apoptosis, Inflammation and Oxidative Stress in LPS‐Induced Acute Kidney Injury by Modulating COX2	5
Loganin exerts neuroprotective effect by inhibiting neuronal pyroptosis in rat with cerebral haemorrhage	5
Restoring Autophagy by Exercise Ameliorates Insulin Resistance Partly via Calcineurin‐Driven TFEB Nuclear Translocation	5
Association between dietary inflammation index and inflammatory bowel disease in adults: Results from National Health and Nutrition Examination Survey 2009–2010	5
Shikonin ameliorates oxidative stress and neuroinflammation via the Akt/ERK/JNK/NF‐κB signalling pathways in a model of Parkinson's disease	5
A 2‐week treatment with 5‐azacytidine improved the hypercontractility state in prostate from obese mice: Role of the nitric oxide‐cyclic guanosine monophosphate signalling pathway	5
Propofol attenuates prostate cancer progression by upregulating TRHDE‐AS1 expression, and METTL14 could mediate its m6A modification	5
Issue Information	5
Whole‐exome sequencing‐based mutational profiling of hepatocellular adenoma malignant transformation to hepatocellular carcinoma	5
Application of 3D computed tomography in emphysematous parenchyma patients scheduled for bronchoscopic lung volume reduction	5
Growth hormone‐releasing hormone beyond cancer	5
Caffeic acid phenethyl ester ameliorates colistin‐induced nephrotoxicity in rats via modulation of FOXO1/Nrf2/Sirt1 axis	5
Study on the anti‐inflammatory effect of stachyose by inhibiting TLR4/NF‐κB signalling pathway in vitro and in vivo	5
Olfactory training for olfactory dysfunction in COVID‐19: A promising mitigation amidst looming neurocognitive sequelae of the pandemic	5
Synergic actions of botulinum neurotoxin A and oxaliplatin on colorectal tumour cell death through the upregulation of TRPM2 channel‐mediated oxidative stress	5
Endothelin System Blockade Extenuates Sepsis‐Induced Acute Heart and Kidney Injuries via Modulating ET‐1/Klotho/p38‐MAPK	5
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Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats	5
PD‐L1/PD‐L1 signalling promotes colorectal cancer cell migration ability through RAS/MEK/ERK	5
Comprehensive analysis of EphA2 in pan‐cancer: A prognostic biomarker associated with cancer immunity	5
Issue Information	5
Issue Information	4
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SMYD2 epigenetically activates MEX3A and suppresses CDX2 in colorectal cancer cells to augment cancer growth	4
Issue Information	4
Disk diffusion‐based method aids in the detection of vanM‐positive Enterococcus faecium with low vancomycin minimum inhibitory concentrations	4
Biochemical Investigation of the Association of Apolipoprotein E Gene Allele Variations with Insulin Resistance and Amyloid‐β Aggregation in Cardiovascular Disease	4
Pretreatment with nicotinamide mononucleotide increases the effect of ischaemic postconditioning on cardioprotection and mitochondrial function following ex vivo myocardial reperfusion injury in aged	4
Issue Information	4
Cancer‐associated fibroblast‐derived circFARP1 modulates non–small cell lung cancer invasion and metastasis through the circFARP1/miR‐338‐3p/SOX4 axis	4
Research trends in ferroptosis since the origin of the concept: A bibliometric analysis	4
Activation of GPR39 Ameliorates Placental Dysfunction by Inhibiting Activation of NLRP1 Inflammasome in Gestational Diabetes Mellitus	4
Palovarotene inhibits the NF‐κB signalling pathway to prevent heterotopic ossification	4
Glaucocalyxin A induces apoptosis of non–small cell lung carcinoma cells by inhibiting the PI3K/Akt/GSK3β pathway	4
Impact of JAK/STAT inhibitors on human monocyte‐derived‐macrophages stimulated by cigarette smoke extract and lipopolysaccharide	4
Issue Information	4
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Metabotropic glutamate receptor 5 blockade attenuates pathological cardiac remodelling in pulmonary arterial hypertension	4
Potential roles of ellagic acid on metabolic variables in diabetes mellitus: A systematic review	4
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Dantrolene and ryanodine receptors in COVID‐19: The daunting task and neglected warden	4
Electrical modelling of tissue experiments confirms precise locations of resistance and compliance in systemic arterial tree—they are mutually exclusive	4
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Early and Stable Mouse Model of Amphotericin B‐Induced Acute Kidney Injury: Application of Continuous Non‐Invasive GFR Monitoring	4