OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Experimental Pharmacology and Physiology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Ulinastatin affects focal cerebral ischemia–reperfusion injury via SOCS1‐mediated JAK2/STAT3 signalling pathway	37
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LncRNA Miat knockdown alleviates endothelial cell injury through regulation of miR‐214‐3p/Caspase‐1 signalling during atherogenesis	32
Withdrawn: ‘Tripartite motif 8 (TRIM8) plays a protective role in a cell model of Parkinson's disease via modulation of NF‐ κB activation through targeting of IκBa ubiquitination’, Yingqiao Pan	32
Dexmedetomidine attenuates one‐lung ventilation associated lung injury by suppressing inflammatory responses: A systematic review and meta‐analysis	31
Reliability of Matrix‐Assisted Laser Desorption‐Ionisation Time‐of‐Flight Mass Spectrometry as a Method for Drug‐Resistant Tuberculosis Gene Identification	29
Efficacy and safety of baricitinib for the treatment of moderate‐to‐severe atopic dermatitis: A systematic review and meta‐analysis of randomized clinical trials	29
Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells	28
MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability	28
Fibroblast growth factor 10 ameliorates renal ischaemia–reperfusion injury by attenuating mitochondrial damage	26
Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3‐mediated ZO‐1 expression	25
The impact of metformin on hypothalamic–pituitary–thyroid axis activity in postmenopausal women with untreated non‐autoimmune subclinical hypothyroidism	23
LncRNA PRKCQ‐AS1 regulates paclitaxel resistance in triple‐negative breast cancer cells through miR‐361‐5p/PIK3C3 mediated autophagy	22
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The RNA N⁶‐methyladenosine modulator HNRNPA2B1 is involved in the development of non‐small cell lung cancer	21
SIRT1 targeted by miR‐211‐5p regulated proliferation and apoptosis of Dex‐treated growth plate chondrocytes via mediating SOX2	21
Correction to “low‐intensity pulsed ultrasound prevents prolonged hypoxia‐induced cardiac fibrosis through HIF‐1α/DNMT3a pathway via a TRAAK‐dependent manner”	18
Corticosterone‐Induced Myocardial Dysfunctions and the Cardioprotective Role of Tauroursodeoxycholic Acid: An Experimental Study in Mice	18
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Prefrontal cortex pyramidal neurons express functional Nav1.8 tetrodotoxin‐resistant sodium currents	17
Development and Validation of a Comprehensive Risk Prediction Model for Polypoid Lesions of the Gallbladder	17
Effects of a single dose of rocuronium in patients with different body fat percentages: A randomised controlled trial	16
Myrtenol complexed with β‐cyclodextrin ameliorates behavioural deficits and reduces oxidative stress in the reserpine‐induced animal model of Parkinsonism	16

Weight‐based oxytocin infusion for preventing uterine atony during caesarean delivery in non‐labouring patients: A dose–response study	16
Association between anti‐fibrillin‐2 protein induced retinal degeneration via intravitreous delivery and activated TGF‐β signalling in mice	16
Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2	16
Connexin 43 participates in atrial electrical remodelling through colocalization with calcium channels in atrial myocytes	16
ALKBH5 inhibits the SIRT3/ACC1 axis to regulate fatty acid metabolism via an m6A‐IGF2BP1‐dependent manner in cervical squamous cell carcinoma	15
The expected advantage of administering prophylactic antibiotics using target‐ concentration controlled infusion: Development of a new pharmacokinetic model of cefazolin	15
Cardioprotective effects of amiodarone in a rat model of epilepsy‐induced cardiac dysfunction	15
Substance P ameliorates TNF‐α‐mediated impairment of human aortic vascular cells in vitro	14
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EZH2 promotes the progression of osteosarcoma through the activation of the AKT/GSK3β pathway	13
Cardioprotective effects of the proline‐rich oligopeptide Bj‐PRO‐7a in spontaneously hypertensive rats	13
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AEBP1 restores osteoblastic differentiation under dexamethasone treatment by activating PI3K/AKT signalling	12
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Propofol suppresses cell proliferation in gastric cancer cells through NRF2‐mediated polyol pathway	12
The effects of mirabegron on obesity‐induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue	11
Differential effects of inhibitors of PTZ‐induced kindling on glutamate transporters and enzyme expression	11
A single bout of exhaustive treadmill exercise increased AMPK activation associated with enhanced autophagy in mice skeletal muscle	11
Adrenalectomy attenuates hyperalgesia but does not regulate muscle wasting in a female rat model of fibromyalgia	11
Bufalin reduces myocardial infarction‐induced myocardial fibrosis and improves cardiac function by inhibiting the NLRP3/IL‐1β signalling pathway	11
Rovatirelin ameliorates motor dysfunction in the cytosine arabinoside‐induced rat model of spinocerebellar degeneration via acetylcholine and dopamine neurotransmission	10
Effects of food on the pharmacokinetics of ensartinib in healthy Chinese subjects	10
Protective effect of melatonin and ascorbic acid combination on sepsis‐induced lung injury: An Experimental study	10
Pharmacological characterization of linzagolix, a novel, orally active, non‐peptide antagonist of gonadotropin‐releasing hormone receptors	10
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Retraction statement: Zhang K, Wang L, Chen H, Shi Y, Liu Y, Liu J, Hong X, Liu J‐P. Pulmonary alveolar stem cells undergo senescence, apoptosis and differentiation by p53‐dependent and ‐independent m	9
Reinvestigation of the tonic natriuretic action of intrarenal dopamine: comparison of two variants of salt‐dependent hypertension and spontaneously hypertensive rats	9
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Artesunate alleviates psoriasis‐like dermatitis by reducing interleukin‐23 expression in tumor necrosis factor‐alpha‐induced HaCaT cells	9
GSK3β inhibitor TDZD8 ameliorates brain damage through both ROS scavenging and inhibition of apoptosis in hyperglycaemic subarachnoid haemorrhage rats	9
TLR4 Inhibitor TAK‐242 Protected Henoch–Schonlein Purpura Nephritis in Rats by Regulating Inflammatory Response and Immune Competence via NF‐ κB/NLRP3<	9
Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression	9
Angiotensin receptor‐neprilysin inhibitor attenuates cardiac hypertrophy and improves diastolic dysfunction in a mouse model of heart failure with preserved ejection fraction	8
RETRACTION: Diosmetin Exerts Cardioprotective Effect on Myocardial Ischaemia Injury in Neonatal Rats by Decreasing Oxidative Stress and Myocardial Apoptosis	8
A spontaneous hyperglycaemic cynomolgus monkey presents cognitive deficits, neurological dysfunction and cataract	8
Possible involvement of apoptosis in the antipsychotics side effects: A mini‐review	8
Therapeutic potential of curcumin in ARDS and COVID‐19	8
Erythropoietin hyporesponsiveness in non‐alcoholic fatty liver disease	8
Sevoflurane‐induced P300 promotes neuron apoptosis via Sp1/CDK9 pathway	8
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Electroacupuncture Attenuates Cerebral Ischemia–Reperfusion Injury by Inhibiting Ferroptosis via the p53/SLC7A11 Pathway	8
Nicorandil mitigates amiodarone‐induced pulmonary toxicity and fibrosis in association with the inhibition of lung TGF‐β1/PI3K/Akt1‐p/mTOR axis in rats	8
Thioredoxin‐1 regulates the autophagy induced by oxidative stress through LC3‐II in human lens epithelial cells	8
Sex Steroid Control of Serotonergic System: Clinical Implications for Psychiatric Disorders and Addiction Treatment	8
Isoferulic Acid Inhibits Proliferation and Migration of Pancreatic Cancer Cells, and Promotes the Apoptosis of Pancreatic Cancer Cells in a Mitochondria‐Dependent Manner Through Inhibiting NF	8
Rapid detection of guttae area using aniline blue staining in Fuchs endothelial corneal dystrophy mouse model	8
The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases	8
Investigation of the effect of ghrelin on bone fracture healing in rats	8

Esculentoside A ameliorates DNCB‐induced atopic dermatitis by suppressing the ROS‐NLRP3 axis via activating the Nrf2 pathway	7
Issue Information	7
Global, Regional, and National Temporal Trend and Patterns of Change in the Burden of Asthma From 1990 to 2021: An Analysis of the Global Burden of Disease Study 2021	7
BCR::ABL1‐positive chronic myeloid leukaemia with CALR mutation	7
Bromocriptine therapy: Review of mechanism of action, safety and tolerability	7
Sirt6, Deubiquitinated and Stabilised by USP9X, Takes Essential Actions on the Pathogenesis of Experimental Autoimmune Myasthenia Gravis by Regulating CD4⁺ T Cells	7
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Prognostic value of inflammatory and nutritional indexes among advanced NSCLC patients receiving PD‐1 inhibitor therapy	7
Phosphatidylserine accelerates wound healing and reduces necrosis in the rats: Growth factor activation	7
Hsa_circ_0001204 modulates inflammatory response of macrophages infected by Mycobacterium tuberculosis via TLR4/NF‐κB signalling pathway	7
Inhibition of mTOR by temsirolimus overcomes radio‐resistance in nasopharyngeal carcinoma	7
Tau and stathmin proteins in breast cancer: A potential therapeutic target	7
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ICOS⁺ follicular regulatory T cells are implicated in the pathogenesis of ulcerative colitis	6
Hsa_circ_0097922 promotes tamoxifen resistance and cell malignant behaviour of breast cancer cells by regulating ACTN4 expression via miR‐876‐3p	6
GLP‐1 receptor agonist liraglutide alleviates kidney injury by regulating nuclear translocation of NRF2 in diabetic nephropathy	6
A 2‐week treatment with 5‐azacytidine improved the hypercontractility state in prostate from obese mice: Role of the nitric oxide‐cyclic guanosine monophosphate signalling pathway	6
Comprehensive analysis of EphA2 in pan‐cancer: A prognostic biomarker associated with cancer immunity	6
Endothelin System Blockade Extenuates Sepsis‐Induced Acute Heart and Kidney Injuries via Modulating ET‐1/Klotho/p38‐MAPK	6
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Metabolomic modelling and neuroprotective effects of carvacrol against acrylamide toxicity in rat's brain and sciatic nerve	6
In vitro effects and mathematical modelling of CTCE‐9908 (a chemokine receptor 4 antagonist) on melanoma cell survival	6
Thromboxane A₂ receptor antagonist (ONO‐8809) attenuates renal disorders caused by salt overload in stroke‐prone spontaneously hypertensive rats	6
Exosomal miR‐21‐5p derived from multiple myeloma cells promote renal epithelial–mesenchymal transition through targeting TGF‐β/SMAD7 signalling pathway	6
Discovery of a chalcone derivative as potent necroptosis inhibitor for the treatment of acute kidney injury	6
Relationship between serum CHIP levels with cardiovascular disease in maintenance haemodialysis patients	6
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Agomelatine alleviates steroid‐induced osteoporosis by targeting SIRT1/RANKL/FOXO1/OPG signalling in rats	6
Olfactory training for olfactory dysfunction in COVID‐19: A promising mitigation amidst looming neurocognitive sequelae of the pandemic	6
The renal excretory responses to acute renal interstitial angiotensin (1–7) infusion in anaesthetised spontaneously hypertensive rats	6
Scutellarin inhibits oleic acid induced vascular smooth muscle foam cell formation via activating autophagy and inhibiting NLRP3 inflammasome activation	6
Association between dietary inflammation index and inflammatory bowel disease in adults: Results from National Health and Nutrition Examination Survey 2009–2010	5
Icariin attenuates ischaemic stroke through suppressing inflammation mediated by endoplasmic reticulum stress signalling pathway in rats	5
Study on the anti‐inflammatory effect of stachyose by inhibiting TLR4/NF‐κB signalling pathway in vitro and in vivo	5
Nimodipine reduces delayed cerebral vasospasm after intracranial tumour surgery: A Retrospective Study	5
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Loganin exerts neuroprotective effect by inhibiting neuronal pyroptosis in rat with cerebral haemorrhage	5
PD‐L1/PD‐L1 signalling promotes colorectal cancer cell migration ability through RAS/MEK/ERK	5
Growth hormone‐releasing hormone beyond cancer	5
Propofol attenuates prostate cancer progression by upregulating TRHDE‐AS1 expression, and METTL14 could mediate its m6A modification	5
Synergic actions of botulinum neurotoxin A and oxaliplatin on colorectal tumour cell death through the upregulation of TRPM2 channel‐mediated oxidative stress	5
Restoring Autophagy by Exercise Ameliorates Insulin Resistance Partly via Calcineurin‐Driven TFEB Nuclear Translocation	5
Renalase—A new understanding of its enzymatic and non‐enzymatic activity and its implications for future research	5
Shikonin ameliorates oxidative stress and neuroinflammation via the Akt/ERK/JNK/NF‐κB signalling pathways in a model of Parkinson's disease	5
Caffeic acid phenethyl ester ameliorates colistin‐induced nephrotoxicity in rats via modulation of FOXO1/Nrf2/Sirt1 axis	5
Whole‐exome sequencing‐based mutational profiling of hepatocellular adenoma malignant transformation to hepatocellular carcinoma	5
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