Medical Hypotheses

Article	Citations
Could cuproptosis be a novel therapeutic target for tooth eruption disturbances	38
Dynamic tissue distraction may enhance therapeutic efficacy for Critical limb ischemia	16
A quantum mechanical explanation for auditory-visual hallucinations	16
Stellate Ganglion Block may represent an effective therapeutic for Primary Sjögren’s Syndrome	16
The potential mechanisms of pain relief in patients after percutaneous vertebroplasty: Intravertebral pressure release and peripheral nerve ablation	14
Integration of parenteral nutrition with galactose may improve neurodevelopmental outcomes for preterm newborns	13
Unraveling the impact of technology on immunological learning: What is the immune system listening to?	12
Editorial Board	12
Long-term neurological implications of severe acute respiratory syndrome coronavirus 2 infections in neonates: Innate immune memory and chronic neuroinflammation	12
Could sleep quality in pregnant women be related to developmental defects of enamel in children?	12
Vaccine enhancement and improved immunogenicity using erythrocytes as carriers	11
Acupressure at LI4 and LU10 as a modulator of cortical microstates and autonomic tone: a hypothetical mechanism	11
Progesterone-induced blocking factor and interleukin 4 as novel therapeutics in the treatment of recurrent pregnancy loss	11
Post-menopause cardiovascular risk – lack of hormones or bleeding? – Increased blood viscosity due to cessation in menstrual bleeding	11
Osteoclasts may play key roles in initiating biomaterial-induced ectopic bone formation	11
Can virophages be used for management of viral infections?	10
A novel therapeutic approach for allergic rhinitis by exosome-mimetic nanovesicles derived from mesenchymal stem cells to restore nasal mucosal epithelial barrier	10
Delivery of PTEN protein into tumor cells as a promising strategy for cancer therapy via active albumin nanoparticles: A hypothesis	10
Protective effect of methylene blue in iron-induced neurotoxicity	10
Editorial Board	9
The mechanical protector paradox: a hypothesis linking transition zone enlargement, urethral angle, and carcinogenesis via intraprostatic reflux	8
Hypothesis: Hypermobile Ehlers Danlos Syndrome is a determinant of fetal and young infant bone strength	8
Targeting survival without morbidity: Heart rate characteristics for oxygen supplementation optimization in neonatal care	7
Editorial Board	7
NIoBReTH: A novel integrative paradigm of protection against SARS-CoV-2 and other airborne pathogens with fewer socioeconomic constraints	7

Chrono-regulation of AR-V7: A potential temporal driver of hormone resistance in prostate cancer?	7
Exploring the link between sacral neuromodulation and body balance mechanism	7
Amelioration of social impairments in autism: Possible role of vagal afferent stimulation in modification of the prefrontal-amygdala connectivity	7
A new neonatal gastro-intestinal physiology-and pyloric stenosis of infancy a hypothesis	7
Psilocybin to promote synaptogenesis in the brains of patients with mild cognitive impairment	6
Activation of resident immune cells induces enteric neuronal death	6
Development of a novel mucosal multi-epitope subunit vaccine against Clostridioides difficile, incorporating recombinant Outer membrane Vesicles and spores	6
Acute diffuse brain swelling during surgery — Hypothalamic injury or the “dual-switch” hypothesis	6
A novel intrauterine barrier for preventing the recurrence of IUA after TCRA procedure	6
Editorial Board	6
Local hematoma may be a cause of peripheral fusion after spinal surgery	6
Parkinson’s disease as a superposition of wake and sleep states: a hypothesis of vicious cycle neurodegeneration	6
Fundamental disincorporation and early non-inflammatory microglia alterations: Possible bridging phenomena between neurobiology and psychopathology in schizophrenia	6
Why is the inferior aspect of the shoulder joint unprotected and weakest? A theory on brachiation and bipedalism	5
Targeting the hypothalamic MC4 receptor: A novel approach to senolytic therapy?	5
A novel hypothesis on the pathogenesis of knee osteoarthritis: the muscle weakness-joint instability and stress overload – uneven bone settlement cascade	5
Molecular hydrogen and heat-stressed exercise: a mechanistic hypothesis and framework for future investigation	5
Periodontitis could affect functional connectivity in the brain leading to worsening of neuro psychiatric disorders – A hypothesis	5
Regular intake of vasodip (lercanidipine) relieves migraine attacks	5
The hypothesis – A dual-front attack on TB: Vitamin D–fluoroquinolone conjugates as next generation therapeutic strategy against drug-resistant Mycobacterium tuberculosis	5
A novel hypothesis about abnormalities in ependymal ciliary cytoskeleton driving the development of syringomyelia-associated scoliosis and its potential mechanism	5
Nasal breathing and brain Function: A hypothesis of nasal cavity as a localized interface for gas exchange	5
Iron chelators reduce prostaglandins and leukotrienes by inhibiting cyclooxygenase and lipoxygenase: A hypothesis to attenuate PPARγ transcriptional activity in prostate cancer	5
Editorial Board	5
Phrenic nerve neurorrhaphy with a sural nerve graft in unilateral diaphragmatic paralysis	5
Cigarette smoke as a superspreading vector of SARS-CoV-2, measles virus, and influenza virus: A hypothesis on virus-laden aerosol formation and transport	5
Multiple sclerosis, extra-mitochondrial energy production in myelin and transgenerational effects of lead exposure: Possible connections	5
Schizophrenia’s gene expression defies clarity: Insights from postmortem brain data	5
Insight into the possible therapeutic implication of the α-oxoaldehyde glyoxal in the treatment of viral infection	5
Controlled intracranial pressure elevation via cerebrospinal fluid infusion: a novel hemostatic hypothesis for hematoma expansion in traumatic brain contusion	5
Use of natural cysteine protease inhibitors in limiting SARS-Co-2 fusion into human respiratory cells	5
Abulia is mediated by the neural pathways responsible for passivity symptoms with initiated actions remaining subject to conscious veto	4
RETRACTED: Sickle Cell Crisis – Home Oxygen in the Golden Half Hour, can prevent or stop a crisis, prevent complications and change the trajectory of disease	4
Far beyond experiments or myths – Medical Hypotheses is a provocative resource that helps students to think about science with criticism	4
Does habitual squatting account for the ethnic difference in hip osteoarthritis?	4
Species-specific biofilm traits and virulence gene expression in recurrent vulvovaginal candidiasis: a translational hypothesis	4
WITHDRAWN: Elevated histamine etiology model for most major vaccine associated adverse events including SARS-CoV-2 spike vaccines	4
Crabtree effect as a parallel pathogenetic pathway in diabetic retinopathy	4
Reply to: “Is there a genetic link between keratoconus and Fuch’s endothelial corneal dystrophy?”	4
A theory on the pathogenesis of Leber hereditary optic neuropathy: Two hits and the role of light toxicity	4
Could digoxin treat tachyarrhythmias in severe methylxanthine overdose?	4
Can human metapneumovirus infection be prevented by exercise?	4
Hypothesis on the potential of repetitive transcranial magnetic stimulation to modulate neurochemical pathways and circadian rhythm in ADHD	4
Increased intracranial pressure due to chronic weight lifting exercises as a hypothesis of partial empty sella syndrome in an elite athlete	4
Colonic mast cells trigger enteric neuronal death through the S100β/RAGE/NFκB pathway on inflammatory bowel diseases	4
Effects of biological clock on acute pancreatitis: Roles and mechanisms	4
Autophagy: A self-guard against SARS-CoV-2	4
Marginal BH4 deficiencies, iNOS, and self-perpetuating oxidative stress in post-acute sequelae of Covid-19	4
A hypothesis exploring gender differences in gait variability using rhythmic auditory stimulation in individuals with Parkinson’s disease	4
Editorial Board	4

Prolonged unexplained event might change an “unreliable perpetrator” into a “reliable resuscitator”	4
Tubular visual field defect relies on hyperbolic geometry spatial representations	4
Pathological Demand Avoidance is a result of mental process opacity	4
Assessing the structural and functional changes in vagus nerve in multiple sclerosis	4
Snoring may transmit infectious aerosols from the upper to the lower respiratory tract	4
A promising method for reducing the incidence of diabetic foot ulcers: Regulating foot temperature during walking	4
Corrigendum to “A hypothesis linking the Renin-Angiotensin, Kallikrein-Kinin systems, and disseminated coagulation in Covid-19” [Med. Hypothesis 192 (2024) 111488]	4
Strategic combinatorial delivery of tranilast and paclitaxel using differently functionalized PLGA nanoparticles for enhanced penetration and accumulation in Breast tumor	4
Bayesian interpretation of the hygiene hypothesis	4
Editorial Board	4
Is iron dysregulation in the mirror motor cortex associated with misophonia?	4
Osteoclasts may play key roles in initiating vascular calcification during atherosclerosis	3
Comment on: Central effects of Stellate Ganglion Block mediated by the vagus nerve? An alternate hypothesis for treating PTSD	3
Editorial Board	3
Attenuation of tryptophan metabolism by Fe chelators: A hypothesis regarding inhibiting tumor suppressive microenvironments in pancreatic ductal adenocarcinoma	3
How the somatosensory system adapts to the motor change in Stroke: A hemispheric Shift?	3
The concept of psychotic arousal and its relevance to abnormal subjective experiences in schizophrenia. A hypothesis for the formation of primary delusions	3
Editorial Board	3
Progressive overload in cardiorespiratory exercise training for young and old: Is increasing duration or intensity of exercise more important?	3
Synergistic anticancer activity of Sulphoraphane and Teriflunomide co loaded lignin nanoparticles against triple negative breast cancer: Targeted nanoparticle delivery and drug repurposing	3
Late intraocular lens dislocation arises from two independent biomechanical pathways: Structural failure and interface fatigue	3
Extending mental practice to sleep: Enhancing motor skills through lucid dreaming	3
Low endogenous deoxyribonuclease activity in the colon as a factor contributing to the pathogenesis of ulcerative colitis	3
Potential circadian rhythms impacts on amblyopia treatment outcomes	3
Could ancient Yamnaya dairying explain the environmental component of multiple sclerosis?	3
Stress-conditioned small extracellular vesicles from young cells to restore resilience in aging	3
Speed as a compensatory stabilizer: the momentum-dependent hypothesis of pediatric gait maturation and its implications for hidden motor deficits	3
Alzheimer’s disease is a result of loss of full brain buoyancy	3
From telomere extension to tryptophan superradiance: a proposed experiment to test whether cellular rejuvenation restores biophoton emission coherence	3
Metabolic dysfunction associated steatotic liver disease as a disorder of hepatic bioenergetic timing	3
Pleasure and displeasure in self-mutilation: A hypothesis for opponent process theory?	3
Creatine supplementation as a dual therapeutic strategy for sarcopenia and immune dysregulation in systemic lupus erythematosus: A hypothesis-driven approach	3
“Chelation therapy applied to the treatment of oral Peri-implantitis: A hypothesis”	3
Novel amino-acid based metal–organic frameworks (Bio-MOFs) as hemostatic agents: Unveiling promising frontiers in hemostasis	3
Proximal fibular osteotomy as a treatment for degenerative meniscal extrusion	3
Regarding the paradox of increased coronary atherosclerosis among highly trained athletes: Might hepcidin be the culprit?	3
Hybrid GAN–P-TransUNet framework for alveolar bone regeneration in dental implant planning: A hypothesis	3
Pre-eclampsia and eclampsia pathogenesis utilizes iron released by a hemolytic protozoan parasite	3
Alleviating morphine-induced itching while sustaining its analgesic efficacy: Esketamine as a potential co-administrating choice	3
Handgrip exercise: An innovative non-pharmacological strategy for chronic hypertension in pregnancy	3
The Lazarus’ sign: A novel hypothesis on its hodology and neurophysiological mechanisms	3
Exercise may enhance the anti-metastatic effects of cyclooxygenase 1 inhibitors	3
Central vs peripheral vascular factors determining risk of aortic dissection	3
A hidden element governing immunogenicity in tumoral neoepitopes	3
Targeting conserved dynamic regions of SARS-CoV-2 spike protein identified by normal mode analysis for broad-spectrum antiviral therapy	3
Adipocytes in obesity: A perfect reservoir for SARS-CoV-2?	3
A diametrically opposed view of the role of glucocorticoids in central serous chorioretinopathy	3
The role of Natural Killer cells in pregnancy and their potential impact on cancer prevention	3
Are fenestrations in peripheral pre-Descemet’s layer the route for intracameral air bubble migration during femtosecond LASIK?	3
Can Bacillus Calmette-Guérin (BCG) treat localized prostate cancer?	3
Distinct contribution of monocarboxylate transporter 2 to infantile epileptic spasms syndrome	3
Editorial Board	3
Editorial Board	3
Platelet concentrates may affect the formation of pathological scars by regulating epithelial to mesenchymal transition	3
A substrate-competition hypothesis for type 2 diabetes driven by nutrient excess rather than a primary insulin-signaling defect	3
Bayesian predictive coding hypothesis: Brain as observer’s key role in insight	3
Delayed acclimatization and persistent hyperdynamic circulation amplify capillary stress in severe high-altitude illness	3
Fluoride as a potential contributory factor in pathogenesis of oral submucous fibrosis: A novel hypothesis	3
How fluency-enhancing conditions reduce stuttering. A unified explanation	3
Correspondence to ’A quantum mechanical explanation for auditory-visual hallucinations by Liam Greenacre’	3
HIV-induced neuroinflammation may influence an increase in sexual behavior: A testable hypothesis	3
COUP-TFII as a potential therapeutic target for metabolic dysfunction-associated steatotic liver disease	3
Red blood cells as intelligent antioxidant carriers to rescue sperm in in vitro fertilization (IVF): A hypothesis	2
Microglia harmonize the cerebral lymphoid system clearance in perioperative neurocognitive disorders by the ATP-AMP-ADO pathway	2
Editorial Board	2
Acidic solution irrigation as a novel approach for treating infected walled-off pancreatic necrosis	2
Is vestibular migraine really a separate form of migraine?	2
Editorial Board	2
Do ‘nature’ mediate stem cells empowerment in women?	2
Fibrosis-associated DDR1 downregulation contributes to a better prognosis in oral squamous cell carcinoma associated with oral submucous fibrosis	2
Retroviral synergy in oncogenesis via additive and cooperative protein actions and cross-reactivity of antiretroviral therapy	2
Premaxilla and incisive papilla as a nasopalatine sensory gateway: A developmental hypothesis linking trigeminal V2 afference to brainstem state calibration, oral posture, breathing mode, and childhoo	2
Intrathecal administration of clozapine to reduce side effects: A hypothesis	2
The Stage 1 Plus hypothesis in status epilepticus: predicting resistance before it happens	2
Complement overactivation: A potential mechanistic bridge between immunothrombosis and thromboinflammation in venous thromboembolism	2
A novel etiological approach for the development of knee osteoarthritis in sedentary adults	2
3D Doppler territorial vascular mapping as a prognostic tool in uterine EMV/AVM	2
Applying radiofrequency energy to the penis in the treatment of erectile dysfunction	2
Role of ependymal cilia impairment in syringomyelia formation and its potential mechanism	2
The reverse zoonosis transfer cycle from the human-animal-plant-environment interface: How antibiotic-resistant bacteria from humans threaten the environment and fuel the rise of superbugs	2

Unveiling novel therapeutic avenues: Targeting the cyclin D/CDK4 axis for enhanced cancer treatment	2
Amniotic extracelluar matrix microgels for attenuation of radiation-induced lung injury	2
Does aberrant electrocortical dynamics pattern imply atypical balance control in adolescents with idiopathic scoliosis?	2
Multi-drug loaded microneedles for emergency treatment of snakebite envenomation	2
How were Lactobacillus species selected as single dominant species in the human vaginal microbiota? Coevolution of humans and Lactobacillus	2
The emerging concept of glycocalyx damage as the trigger of heart failure onset and progression	2
Distinctive feeding vessel architecture and sparse collateralization may underlie the characteristic early temporal pole and external capsule white matter compromise in CADASIL	2
A novel strategy combining high-intensity interval training and exogenous ketone supplementation for obesity treatment	2
Intranasal interferon-beta as a promising alternative for the treatment of Alzheimer's disease	2
Erythrocyte enucleation in mammals is an anticancer mechanism: A hypothesis	2
Tailored lipopeptide surfactants as potentially effective drugs to treat SARS-CoV-2 infection	2
Could neutrophil extracellular traps drive the development of autism?	2
Molecular hydrogen as a potential adjuvant therapy for alleviating long COVID	2
Editorial Board	2
Growth differentiation factor 15 activation of AMPK modulates choline/TMAO‑driven calcific aortic valve disease: a novel therapeutic strategy for aortic stenosis	2
The potential role of fixation eye movements in the development of myopia	2
Could mosquito bites facilitate IgE sensitization to food and inhalant allergens?	2
The mint versus Covid hypothesis	2
Möbius strip and cancer	2
Enhancing the effects of mindfulness in migraine patients through transcranial magnetic stimulation: A plausible hypothesis	2
The development and evolution of inner speech: Hippocampal contribution	2
Topical metformin as a novel therapy for alopecia areata due to its immunologic effects	2
Beyond antibiotics: 3d-transition metal ions − serum albumin −indocyanine green complex as a novel multifunctional NIR-responsive therapeutic platform for treating diabetic foot ulcer	2
From treatment of mental disorders to the treatment of difficult life situations: A hypothesis and rationale	2
Could dysbiosis of urban air microbiota be an overlooked contributor to pediatric asthma and neurodevelopmental disorders?	2
Creatine insufficiency as an energetic amplifier of brainstem dysfunction in ME/CFS and long COVID	2
Ischaemic chondronecrosis as a novel causative factor in the aetiopathogenesis of infantile Blount’s disease	2
Electrographic seizures possibly contribute to the epileptogenesis of acquired epilepsy	2
Moderate-intensity exercise as a preventive strategy against dopaminergic dysfunction in Long COVID: A mechanistic hypothesis	2
Hypothesis: Androgen receptor/Aurora A kinase/NF-κB signaling axis induce inflammatory response during polycystic ovarian syndrome progression	2
Asymmetric mechanical stress on both sides of the spine – Based on human functional chiral asymmetry – May constitute the underlying Pathomechanism of adolescent idiopathic scoliosis (AIS)	2
Selenium deficiency and T-2 toxin trigger ferroptosis in cartilage from Kashin-Beck diseases	2
Mesenchymal stromal cell extracellular vesicles: A possible strategy for prevention of preterm birth	2
What are the physiologic effects of Resistance Exercise behind breast cancer-related lymphedema prevention?	2
Brainstem dysfunction as a potential etiology of ME/CFS and long COVID: A mechanical basis	2
A hypothesis on the combination of platelet concentrates and adipocytes promoting wound healing through a bidirectional regulatory mechanism	2
Hypothesis: Platelet-rich plasma accelerate diabetic wound healing via dynamic modulation of multiple signaling pathways	2
Nanoscale self-assembling prodrugs of sulfapyridine for treatment of arthritis: Harnessing the dual approach	2
A combined surgical approach using oral mucosa and allo-SLET to promote corneal epithelial phenotype restoration: a hypothesis	2
Physical exercise and glycemic control: Is HbA1c the best marker for assessing the effects of aerobic training?	2
The maternal epigenome as a window into the in utero environment that the foetus experiences	2
Beyond HbA1c: Can mitochondrial function assessment enhance evaluation of exercise efficacy?	2
Potential therapeutic agent for the treatment of retinal detachment: Artificial interphotoreceptor matrix	2
A bioengineered model for reinnervating the decellularized extracellular matrix of corneal scaffolds	2
Mitochondrial silencing as an apoptosis-evasive metabolic state preceding senescence fixation: A hypothesis	2
When to intervene in aortic stenosis; can cardiac troponin I in the first morning urine be our guide?	2
Reactive retinal vasodilation may mask capillary loss in eyes without diabetic retinopathy and isolated neurodegeneration	2
A hypothesis to explain the potential influence of hormones on the severity of autism spectrum conditions in women	2
Is paracetamol a neuroendocrine disruptor of the developing sexual brain?	2
Time and the body: A new approach to disease	2
Temporal-scaffolding: a model linking internal clocks, oscillatory dynamics, and phenomenology in mood and psychotic disorders	1
The potential association between salivary gland hypofunction and systemic homeostasis	1
The role of hemispheric sensory shifts: Impacts on stretch reflex and motor plasticity post-stroke	1
13C-methionine breath test for the non-invasive detection of advanced metabolic dysfunction-associated steatotic liver disease	1
Traffic-derived metal bioaccumulation in bone tissue as a driver of osteoporosis	1
Comment on: “Obesity paradox in acute myocardial infarction: Is plasminogen activator inhibitor 1 the culprit?”	1
Personalized repetitive transcranial magnetic stimulation guided by the spectral electroencephalogram may enhance and democratize therapy for autism spectrum disorder	1
Shedding light on an enigmatic occlusal condition: hypothesis on the etiology of occlusal dysesthesia	1
Reducing fibrosis progression of biliary atresia by continuous administration of aducanumab at low dose: A potential treatment	1
Downregulation of interleukin-13 as a possible proxy for ergolytic effects of hydrogen gas	1
Can we reduce cancer progression via disrupting autophagy-cholesterol uptake nexus?	1
Tissue thinning in the inguinal region following human bipedalism	1
Can delayed grafting of frozen teeth achieve periodontal ligament healing?	1
Why do some tali collapse in avascular necrosis while others don’t? A biomechanical hypothesis based on a three-pillar load model	1
Do osmotic pressure and hygroscopicity of areca nut related products drive extracellular fluid loss and condensation of collagen bundles in oral submucous fibrosis?	1
The cheeky ape hypothesis: Is rosacea the evolutionary price of human buccal fat?	1
A hypothesis on the suitability of the aquatic crustacean, Daphnia pulex as an animal model for investigating Parkinson’s disease mechanisms	1
Interaction between the muscarinic system and the PPAR-γ may mitigate the severity of inflammatory bowel disease	1
Is Epstein Barr virus latency protective against type 1 diabetes?	1
Potential cellular intravesical therapy for non-muscle invasive bladder cancer: Nectin-4 targeted CAR-T cell therapy	1
Altered iron homeostasis in neonatal hypoxic-ischemic encephalopathy	1
Editorial Board	1
Editorial Board	1
Female urinary continence mechanism: a dynamic biomechanical balance	1
MALAT1: A novel hypothesis on the pathology of vascular injury in patients with β-thalassemia	1
Venous intracerebral hemorrhage hypotheses: Hydrostatic pressure-induced bleeding mechanism and comparative analysis with arterial hemorrhage	1
Neuro-entero-cardiac bridge: could gut-derived catecholamine-loaded extracellular vesicles synchronize the pathogenesis of Parkinson’s disease, irritable bowel syndrome, and stress-triggered arrhythmi	1
A hypotheses to explain acute adjustment disorder after phakic intraocular lens implantation in a highly myopic patient: Potential causes and suggested remedies	1
Van Gogh, lateral tilt, and the El Greco fallacy	1
Infrapatellar fat pad resection: A potential approach for slowing knee osteoarthritis progression	1
Multifaceted efficacy of caspofungin against fungal infections in COVID-19 patients	1
Evolution of male-to-female oral sex as a detection tool of bacterial vaginosis and subsequent infertility	1
The fundamental role of sleep is the reduction of thermodynamic entropy of the central nervous system	1
Anastomoses between cranial nerves, the dorsal roots of the first four cervical vertebrae, and the sympathetic trunk are key to understanding the types of primary headache and their integrative treatm	1
Editorial Board	1
Editorial Board	1
The possibility of changes of brain activity following myofascial release in patients with nonspecific chronic low back pain: A hypothesis	1
Use of Nile tilapia fish skin in oral submucous fibrosis therapeutics	1
Myocardial cell-derived exosomal miR-155-5p promotes depressive disorders in CVD via microglial SIRT1 pathway	1
Response to: Obesity paradox in acute myocardial infarction: Is plasminogen activator inhibitor 1 the culprit?	1
Immunotherapeutic and immunomodulatory potentials of Antigen-Antibody complex vaccines	1
Deep cervical lymphovenous bypass for Parkinson’s disease: A hypothesis	1
Active Inference as a theoretical framework for external locus of control in chronic pain: the role of aberrant interoceptive integration	1
No one left behind: Inclusion of individuals experiencing homelessness in TBI stem cell therapy	1
Platelets could be key regulators of epithelial/endothelial-to- mesenchymal transition in atherosclerosis and wound healing	1