Medical Hypotheses

Article	Citations
Exciter laser coronary atherectomy (ELCA) can be a powerful weapon in the treatment of chronic thromboembolic pulmonary hypertension (CTEPH)	40
Unraveling the impact of technology on immunological learning: What is the immune system listening to?	31
Long-term neurological implications of severe acute respiratory syndrome coronavirus 2 infections in neonates: Innate immune memory and chronic neuroinflammation	29
Editorial Board	25
Can virophages be used for management of viral infections?	21
Vaccine enhancement and improved immunogenicity using erythrocytes as carriers	20
A novel therapeutic approach for allergic rhinitis by exosome-mimetic nanovesicles derived from mesenchymal stem cells to restore nasal mucosal epithelial barrier	20
Stellate Ganglion Block may represent an effective therapeutic for Primary Sjögren’s Syndrome	15
Could cuproptosis be a novel therapeutic target for tooth eruption disturbances	15
Dynamic tissue distraction may enhance therapeutic efficacy for Critical limb ischemia	14
A quantum mechanical explanation for auditory-visual hallucinations	14
Combination therapy of curcumin and fecal microbiota transplant: Potential treatment of polycystic ovarian syndrome	13
Protective effect of methylene blue in iron-induced neurotoxicity	12
Post-adenoviral-based vaccines Guillain-Barre Syndrome: A proposed mechanism	11
Osteoclasts may play key roles in initiating biomaterial-induced ectopic bone formation	11
Could sleep quality in pregnant women be related to developmental defects of enamel in children?	11
Neuroinflammation as a possible link between attention-deficit/hyperactivity disorder (ADHD) and pain	11
The potential mechanisms of pain relief in patients after percutaneous vertebroplasty: Intravertebral pressure release and peripheral nerve ablation	10
Progesterone-induced blocking factor and interleukin 4 as novel therapeutics in the treatment of recurrent pregnancy loss	10
Delivery of PTEN protein into tumor cells as a promising strategy for cancer therapy via active albumin nanoparticles: A hypothesis	10
Hypothesis: Hypermobile Ehlers Danlos Syndrome is a determinant of fetal and young infant bone strength	10
Speechreading as a secondary diagnostic tool in bipolar disorder	9
The use of negative oxygen ion clusters [O2−(H2O)n] and bicarbonate ions [HCO3−] as the supportive treatment of COVID-19 infections: A possibility	9
Chrono-regulation of AR-V7: A potential temporal driver of hormone resistance in prostate cancer?	9
Are fungi responsible for the pathogenesis of oral lichen planus?	9

NIoBReTH: A novel integrative paradigm of protection against SARS-CoV-2 and other airborne pathogens with fewer socioeconomic constraints	9
Activation of resident immune cells induces enteric neuronal death	9
Targeting survival without morbidity: Heart rate characteristics for oxygen supplementation optimization in neonatal care	9
A novel intrauterine barrier for preventing the recurrence of IUA after TCRA procedure	9
A new neonatal gastro-intestinal physiology-and pyloric stenosis of infancy a hypothesis	9
SIRT1-autophagy axis may inhibit oxidative stress-induced ferroptosis in human nucleus pulposus cells	9
Amelioration of social impairments in autism: Possible role of vagal afferent stimulation in modification of the prefrontal-amygdala connectivity	8
Exploring the link between sacral neuromodulation and body balance mechanism	8
Editorial Board	8
Fighting arterial stiffness: A case for the importance of cardiorespiratory fitness in firefighters	8
Local hematoma may be a cause of peripheral fusion after spinal surgery	8
Multiple sclerosis, extra-mitochondrial energy production in myelin and transgenerational effects of lead exposure: Possible connections	7
Fundamental disincorporation and early non-inflammatory microglia alterations: Possible bridging phenomena between neurobiology and psychopathology in schizophrenia	7
Primary aldosteronism: A consequence of sugar and western Diet?	7
Psilocybin to promote synaptogenesis in the brains of patients with mild cognitive impairment	7
Periodontitis could affect functional connectivity in the brain leading to worsening of neuro psychiatric disorders – A hypothesis	6
Phrenic nerve neurorrhaphy with a sural nerve graft in unilateral diaphragmatic paralysis	6
Why is the inferior aspect of the shoulder joint unprotected and weakest? A theory on brachiation and bipedalism	6
Regular intake of vasodip (lercanidipine) relieves migraine attacks	6
Investigating myelin oligodendrocyte glycoprotein antibodies in hereditary citrullinemia	6
A novel hypothesis about abnormalities in ependymal ciliary cytoskeleton driving the development of syringomyelia-associated scoliosis and its potential mechanism	6
Insight into the possible therapeutic implication of the α-oxoaldehyde glyoxal in the treatment of viral infection	6
Editorial Board	6
Transient Receptor Potential Vanilloid 1 (TRPV1) as a plausible novel therapeutic target for treating neurological complications in ZikaVirus	6
Targeting the hypothalamic MC4 receptor: A novel approach to senolytic therapy?	6
BP-180-specific IgG antibodies: A potential useful candidate for early diagnosis of Bullous pemphigoid during anti-PD-1/anti-PDL-1 of melanoma patients	5
Schizophrenia’s gene expression defies clarity: Insights from postmortem brain data	5
Vitamin D may prevent COVID-19 induced pregnancy complication	5
Editorial Board	5
Editorial Board	5
Use of natural cysteine protease inhibitors in limiting SARS-Co-2 fusion into human respiratory cells	5
Hypothesis on the potential of repetitive transcranial magnetic stimulation to modulate neurochemical pathways and circadian rhythm in ADHD	5
Age, obesity and hyperglycaemia: Activation of innate immunity initiates a series of molecular interactions involving anionic surfaces leading to COVID-19 morbidity and mortality	5
Strategic combinatorial delivery of tranilast and paclitaxel using differently functionalized PLGA nanoparticles for enhanced penetration and accumulation in Breast tumor	5
Tubular visual field defect relies on hyperbolic geometry spatial representations	5
Mitochondrial hijacking: A potential mechanism for SARS-CoV-2 to impair female fertility	5
Abulia is mediated by the neural pathways responsible for passivity symptoms with initiated actions remaining subject to conscious veto	5
Models for SARS-CoV-2 associated thrombocytopenia associated with hemophagocytic histiocytes	5
Colonic mast cells trigger enteric neuronal death through the S100β/RAGE/NFκB pathway on inflammatory bowel diseases	5
Effects of biological clock on acute pancreatitis: Roles and mechanisms	4
A promising method for reducing the incidence of diabetic foot ulcers: Regulating foot temperature during walking	4
Proposal for assessment of the predominant symptom and physical function in patients suffering from Long COVID	4
Pathological Demand Avoidance is a result of mental process opacity	4
Snoring may transmit infectious aerosols from the upper to the lower respiratory tract	4
Could digoxin treat tachyarrhythmias in severe methylxanthine overdose?	4
Autophagy: A self-guard against SARS-CoV-2	4
Pre-eclampsia and eclampsia pathogenesis utilizes iron released by a hemolytic protozoan parasite	4
Low endogenous deoxyribonuclease activity in the colon as a factor contributing to the pathogenesis of ulcerative colitis	4
Marginal BH4 deficiencies, iNOS, and self-perpetuating oxidative stress in post-acute sequelae of Covid-19	4
Crabtree effect as a parallel pathogenetic pathway in diabetic retinopathy	4

Corrigendum to “A hypothesis linking the Renin-Angiotensin, Kallikrein-Kinin systems, and disseminated coagulation in Covid-19” [Med. Hypothesis 192 (2024) 111488]	4
Reply to: “Is there a genetic link between keratoconus and Fuch’s endothelial corneal dystrophy?”	4
Can human metapneumovirus infection be prevented by exercise?	4
Bayesian interpretation of the hygiene hypothesis	4
A hypothesis exploring gender differences in gait variability using rhythmic auditory stimulation in individuals with Parkinson’s disease	4
Editorial Board	4
Hypothesis of subcortical visual pathway impairment in schizophrenia	4
Prolonged unexplained event might change an “unreliable perpetrator” into a “reliable resuscitator”	4
Increased intracranial pressure due to chronic weight lifting exercises as a hypothesis of partial empty sella syndrome in an elite athlete	4
Does habitual squatting account for the ethnic difference in hip osteoarthritis?	4
WITHDRAWN: Elevated histamine etiology model for most major vaccine associated adverse events including SARS-CoV-2 spike vaccines	4
Far beyond experiments or myths – Medical Hypotheses is a provocative resource that helps students to think about science with criticism	4
Assessing the structural and functional changes in vagus nerve in multiple sclerosis	4
A theory on the pathogenesis of Leber hereditary optic neuropathy: Two hits and the role of light toxicity	4
Prolactin and susceptibility to COVID-19 infection	4
Platelet concentrates may affect the formation of pathological scars by regulating epithelial to mesenchymal transition	4
Could ancient Yamnaya dairying explain the environmental component of multiple sclerosis?	4
l-Methionine may modulate the assembly of SARS-CoV-2 by interfering with the mechanism of RNA polymerase	3
Progressive overload in cardiorespiratory exercise training for young and old: Is increasing duration or intensity of exercise more important?	3
Correspondence to ’A quantum mechanical explanation for auditory-visual hallucinations by Liam Greenacre’	3
Synergistic anticancer activity of Sulphoraphane and Teriflunomide co loaded lignin nanoparticles against triple negative breast cancer: Targeted nanoparticle delivery and drug repurposing	3
Adipocytes in obesity: A perfect reservoir for SARS-CoV-2?	3
Do ‘nature’ mediate stem cells empowerment in women?	3
Intrathecal administration of clozapine to reduce side effects: A hypothesis	3
Editorial Board	3
How the somatosensory system adapts to the motor change in Stroke: A hemispheric Shift?	3
Erratum Regarding Previously Published Articles	3
Glycemia and venous thromboembolism in patients with primary brain tumors – A speculative review	3
Editorial Board	3
Alzheimer’s disease is a result of loss of full brain buoyancy	3
Comment on: Central effects of Stellate Ganglion Block mediated by the vagus nerve? An alternate hypothesis for treating PTSD	3
Supportive therapy during COVID-19: The proposed mechanism of short-chain fatty acids to prevent cytokine storm and multi-organ failure	3
Attenuation of tryptophan metabolism by Fe chelators: A hypothesis regarding inhibiting tumor suppressive microenvironments in pancreatic ductal adenocarcinoma	3
Could fecal microbial transplantation offer a new potential in the treatment of metastatic pancreatic ductal adenocarcinoma?	3
Central vs peripheral vascular factors determining risk of aortic dissection	3
Estimate of benefit attributable to wearing masks in Chicago during the early days of the pandemic	3
Regarding the paradox of increased coronary atherosclerosis among highly trained athletes: Might hepcidin be the culprit?	3
Fluoride as a potential contributory factor in pathogenesis of oral submucous fibrosis: A novel hypothesis	3
Extending mental practice to sleep: Enhancing motor skills through lucid dreaming	3
Molecular hydrogen as a potential adjuvant therapy for alleviating long COVID	3
“Chelation therapy applied to the treatment of oral Peri-implantitis: A hypothesis”	3
Novel amino-acid based metal–organic frameworks (Bio-MOFs) as hemostatic agents: Unveiling promising frontiers in hemostasis	3
Potential circadian rhythms impacts on amblyopia treatment outcomes	3
CCL2/ACKR2 interaction participate in breast cancer metastasis especially in patients with altered lipid metabolism	3
The role of Natural Killer cells in pregnancy and their potential impact on cancer prevention	3
The Lazarus’ sign: A novel hypothesis on its hodology and neurophysiological mechanisms	3
Can Bacillus Calmette-Guérin (BCG) treat localized prostate cancer?	3
Disease is essentially a biodiversity: A hypothesis	3
The concept of psychotic arousal and its relevance to abnormal subjective experiences in schizophrenia. A hypothesis for the formation of primary delusions	3
Are fenestrations in peripheral pre-Descemet’s layer the route for intracameral air bubble migration during femtosecond LASIK?	3
Editorial Board	3
Whole-body vibration combined with exercise may be more effective in lowering blood pressure and arterial stiffness than exercise alone in older adults with hypertension	3
Editorial Board	3
Editorial Board	3
Microglia harmonize the cerebral lymphoid system clearance in perioperative neurocognitive disorders by the ATP-AMP-ADO pathway	3
Transferosomal in situ gel administered through umbilical skin tissues for improved systemic bioavailability of drugs: A novel strategy to replace conventional transdermal route	3
Alleviating morphine-induced itching while sustaining its analgesic efficacy: Esketamine as a potential co-administrating choice	3
Proximal fibular osteotomy as a treatment for degenerative meniscal extrusion	3
Bayesian predictive coding hypothesis: Brain as observer’s key role in insight	3
How fluency-enhancing conditions reduce stuttering. A unified explanation	3
Distinct contribution of monocarboxylate transporter 2 to infantile epileptic spasms syndrome	3
Pleasure and displeasure in self-mutilation: A hypothesis for opponent process theory?	3
Creatine supplementation as a dual therapeutic strategy for sarcopenia and immune dysregulation in systemic lupus erythematosus: A hypothesis-driven approach	3
A hidden element governing immunogenicity in tumoral neoepitopes	3
Electrographic seizures possibly contribute to the epileptogenesis of acquired epilepsy	2
Applying radiofrequency energy to the penis in the treatment of erectile dysfunction	2
Ischaemic chondronecrosis as a novel causative factor in the aetiopathogenesis of infantile Blount’s disease	2
The potential role of fixation eye movements in the development of myopia	2
Distinctive feeding vessel architecture and sparse collateralization may underlie the characteristic early temporal pole and external capsule white matter compromise in CADASIL	2
Role of ependymal cilia impairment in syringomyelia formation and its potential mechanism	2
A novel etiological approach for the development of knee osteoarthritis in sedentary adults	2
Fibrosis-associated DDR1 downregulation contributes to a better prognosis in oral squamous cell carcinoma associated with oral submucous fibrosis	2
Erythrocyte enucleation in mammals is an anticancer mechanism: A hypothesis	2
Tailored lipopeptide surfactants as potentially effective drugs to treat SARS-CoV-2 infection	2
Unveiling novel therapeutic avenues: Targeting the cyclin D/CDK4 axis for enhanced cancer treatment	2
Bridging the gap: Compressing non-unions for proper cellular signaling	2
Regular short exposures to cold environment as an adjunct therapy for patients with sleep apnea syndrome (SAS)	2
Retroviral synergy in oncogenesis via additive and cooperative protein actions and cross-reactivity of antiretroviral therapy	2
Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication	2
When to intervene in aortic stenosis; can cardiac troponin I in the first morning urine be our guide?	2

What are the physiologic effects of Resistance Exercise behind breast cancer-related lymphedema prevention?	2
The digestive Enzyme-Based nasal dysbiosis in Empty nose Syndrome: A theory	2
Editorial Board	2
Heat shock protein 90, death-associated protein kinase 1 and other cold-induced proteins: Who’s to blame for cold-induced inflammasome activation in familial cold autoinflammatory syndromes?	2
A hypothesis to explain the potential influence of hormones on the severity of autism spectrum conditions in women	2
Beyond HbA1c: Can mitochondrial function assessment enhance evaluation of exercise efficacy?	2
The oncoprotective fever hypothesis: Have antibiotics, antimalarials and antipyrectics contributed to the global rise in cancer over the past century?	2
Selenium deficiency and T-2 toxin trigger ferroptosis in cartilage from Kashin-Beck diseases	2
Are there medium to short-term multifaceted effects of the airborne pollutant PM2.5 determining the emergence of SARS-CoV-2 variants?	2
Reactive retinal vasodilation may mask capillary loss in eyes without diabetic retinopathy and isolated neurodegeneration	2
Möbius strip and cancer	2
The maternal epigenome as a window into the in utero environment that the foetus experiences	2
The development and evolution of IS: Hippocampal contribution	2
The reverse zoonosis transfer cycle from the human-animal-plant-environment interface: How antibiotic-resistant bacteria from humans threaten the environment and fuel the rise of superbugs	2
Research in the pruritus of cholestasis: Genetics, behavioral studies, and physiomimetic interorgan models	2
Gut barrier dysfunction and type 2 immunity: Implications for compulsive behavior	2
Mesenchymal stromal cell extracellular vesicles: A possible strategy for prevention of preterm birth	2
Hypothesis: Androgen receptor/Aurora A kinase/NF-κB signaling axis induce inflammatory response during polycystic ovarian syndrome progression	2
From treatment of mental disorders to the treatment of difficult life situations: A hypothesis and rationale	2
Is vestibular migraine really a separate form of migraine?	2
The emerging concept of glycocalyx damage as the trigger of heart failure onset and progression	2
Multi-drug loaded microneedles for emergency treatment of snakebite envenomation	2
Could mosquito bites facilitate IgE sensitization to food and inhalant allergens?	2
Acidic solution irrigation as a novel approach for treating infected walled-off pancreatic necrosis	2
Editorial Board	2
Time and the body: A new approach to disease	2
Hypothesis: Platelet-rich plasma accelerate diabetic wound healing via dynamic modulation of multiple signaling pathways	2
Does aberrant electrocortical dynamics pattern imply atypical balance control in adolescents with idiopathic scoliosis?	2
Hypothesis of immune homeostasis regulator: The nervous system regulates glucose immunometabolism to control immunity	2
Deregulated kynurenine metabolism – An alternate hypothesis for COVID-19 associated anosmia	2
Beyond antibiotics: 3d-transition metal ions − serum albumin −indocyanine green complex as a novel multifunctional NIR-responsive therapeutic platform for treating diabetic foot ulcer	2
Is paracetamol a neuroendocrine disruptor of the developing sexual brain?	2
A bioengineered model for reinnervating the decellularized extracellular matrix of corneal scaffolds	2
Editorial Board	2
Topical metformin as a novel therapy for alopecia areata due to its immunologic effects	2
How were Lactobacillus species selected as single dominant species in the human vaginal microbiota? Coevolution of humans and Lactobacillus	2
The mint versus Covid hypothesis	2
Could neutrophil extracellular traps drive the development of autism?	2
Amniotic extracelluar matrix microgels for attenuation of radiation-induced lung injury	2
The organ transplant recipient, a chimera subject, who develops a neoplastic lesion may be the suitable model to reconstruct the hierarchical organization of tumors	2
Possible influence of neurosteroids in the anxiolytic effects of alpha-casozepine	2
SARM1-mediated wallerian degeneration: A possible mechanism underlying organophosphorus-induced delayed neuropathy	2
Editorial Board	2
Adenosine deaminase and cytokines associated with infectious diseases as risk factors for inflammatory arthritis and methotrexate as a potential prophylactic agent	2
A hypothesis on the combination of platelet concentrates and adipocytes promoting wound healing through a bidirectional regulatory mechanism	2
Nanoscale self-assembling prodrugs of sulfapyridine for treatment of arthritis: Harnessing the dual approach	2
Obesity paradox in acute myocardial infarction: Is plasminogen activator inhibitor 1 the culprit?	2
Intranasal interferon-beta as a promising alternative for the treatment of Alzheimer's disease	2
Physical exercise and glycemic control: Is HbA1c the best marker for assessing the effects of aerobic training?	2
Potential therapeutic agent for the treatment of retinal detachment: Artificial interphotoreceptor matrix	2
Personalized repetitive transcranial magnetic stimulation guided by the spectral electroencephalogram may enhance and democratize therapy for autism spectrum disorder	1
Use of Nile tilapia fish skin in oral submucous fibrosis therapeutics	1
A one-step platform for screening high-efficient and minimal off-target CRISPR/Cas13 crRNAs to eradicate SARS-CoV-2 virus for treatment of COVID-19 patients	1
Reply to: “Is there a genetic link between Keratoconus and Fuch’s endothelial corneal dystrophy?”	1
Potential therapeutic effect of glucagon-like peptide-1 receptor agonists on COVID-19-induced pulmonary arterial hypertension	1
The microbiome-inflammasome hypothesis explains the rarity of small bowel tumors	1
Renin cell baroreceptor and arachidonic acid	1
A new mechanism of SAMHD1 inhibition of HIV-1 infection by induction of autophagy	1
Possible immune mechanisms initiated by 7-ketocholesterol that contribute to synovial oxidative stress and inflammation	1
Implanting sinoatrial node-like pacemaker cells into the substantia nigra of the brain as a novel therapeutic approach for Parkinson’s disease	1
What is the mechanism of loudness hyperacusis in autism?	1
Response to: Obesity paradox in acute myocardial infarction: Is plasminogen activator inhibitor 1 the culprit?	1
Professional responsibility between guidelines and customary practice. A conflict of interest?	1
Is dream progression a Fibonacci spiral? A hypothesis	1
Combatting future variants of SARS-CoV-2 using an in-silico peptide vaccine approach by targeting the spike protein	1
MALAT1: A novel hypothesis on the pathology of vascular injury in patients with β-thalassemia	1
Can we reduce cancer progression via disrupting autophagy-cholesterol uptake nexus?	1
Is Epstein Barr virus latency protective against type 1 diabetes?	1
Editorial Board	1
Obstructive sleep apnea syndrome and life expectancy: Do pharyngeal evolutionary changes matter?	1
Can atrial lead system ameliorate the diagnosis of atrial arrhythmias?	1
Understanding the mechanisms of sudden cardiac death in bipolar disorder: Functional asymmetry in brain-heart interactions as a potential culprit	1
Potential cellular intravesical therapy for non-muscle invasive bladder cancer: Nectin-4 targeted CAR-T cell therapy	1
Targeting the JMJD6/TGF-β axis in prostate cancer by immunotherapy: A potential treatment based on RNA splicing	1
Exploring the role of mTOR signaling pathway in ketamine's therapeutic effects on suicide risk in depression: Insights into circadian dysregulation mechanisms	1
Elevated circulating procathepsin L as a potential biomarker of inflamm-aging	1
Calcitonin gene-related peptide: A biomarker for stroke in SARS-CoV-2 infection?	1
Do circulating autoantibodies commonly found in healthy individuals reduce cancer risk?	1
Traffic-derived metal bioaccumulation in bone tissue as a driver of osteoporosis	1
Editorial Board	1
Infrapatellar fat pad resection: A potential approach for slowing knee osteoarthritis progression	1
Multifaceted efficacy of caspofungin against fungal infections in COVID-19 patients	1
Reducing fibrosis progression of biliary atresia by continuous administration of aducanumab at low dose: A potential treatment	1
High intelligence may exacerbate paediatric inflammatory response to SARS-CoV-2 infection	1
A hypotheses to explain acute adjustment disorder after phakic intraocular lens implantation in a highly myopic patient: Potential causes and suggested remedies	1
The role of hemispheric sensory shifts: Impacts on stretch reflex and motor plasticity post-stroke	1
Editorial Board	1
The synergistic potential of GLP-1R agonist dulaglutide and ghrelin receptor analogue anamorelin in ameliorating muscle atrophy	1
Stool bacterial dysbiosis, Crystalluria and Oxaluria: A SbCO Index value may define risk for recurrence of oxalate nephrolithiasis episode	1
Proposal for adenomyosis classification based on the endometriosis phenotype	1
The oral microbiome and vaccine efficacy	1
Revolution of artificial intelligence in antimicrobial, anti-biofilm, and anti-inflammatory techniques: Smart photo-sonodynamic appliance in the internet of dental things (IoDT)	1
Possible causes of vertigo attacks in Meniere’s disease	1
Altered iron homeostasis in neonatal hypoxic-ischemic encephalopathy	1
Evolution of male-to-female oral sex as a detection tool of bacterial vaginosis and subsequent infertility	1