Medical Hypotheses

Papers
(The median citation count of Medical Hypotheses is 0. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)
ArticleCitations
Exciter laser coronary atherectomy (ELCA) can be a powerful weapon in the treatment of chronic thromboembolic pulmonary hypertension (CTEPH)38
Unraveling the impact of technology on immunological learning: What is the immune system listening to?30
Long-term neurological implications of severe acute respiratory syndrome coronavirus 2 infections in neonates: Innate immune memory and chronic neuroinflammation29
Editorial Board25
A novel therapeutic approach for allergic rhinitis by exosome-mimetic nanovesicles derived from mesenchymal stem cells to restore nasal mucosal epithelial barrier24
Can virophages be used for management of viral infections?24
Vaccine enhancement and improved immunogenicity using erythrocytes as carriers23
Stellate Ganglion Block may represent an effective therapeutic for Primary Sjögren’s Syndrome21
Could cuproptosis be a novel therapeutic target for tooth eruption disturbances21
A quantum mechanical explanation for auditory-visual hallucinations20
Dynamic tissue distraction may enhance therapeutic efficacy for Critical limb ischemia20
The hypothetical molecular pathways of ursolic acid to attenuate the premature ovarian failure in human15
Could sleep quality in pregnant women be related to developmental defects of enamel in children?15
Combination therapy of curcumin and fecal microbiota transplant: Potential treatment of polycystic ovarian syndrome15
Protective effect of methylene blue in iron-induced neurotoxicity15
Post-adenoviral-based vaccines Guillain-Barre Syndrome: A proposed mechanism14
Osteoclasts may play key roles in initiating biomaterial-induced ectopic bone formation14
Hypothesis: Hypermobile Ehlers Danlos Syndrome is a determinant of fetal and young infant bone strength13
Progesterone-induced blocking factor and interleukin 4 as novel therapeutics in the treatment of recurrent pregnancy loss12
Neuroinflammation as a possible link between attention-deficit/hyperactivity disorder (ADHD) and pain11
The potential mechanisms of pain relief in patients after percutaneous vertebroplasty: Intravertebral pressure release and peripheral nerve ablation11
Delivery of PTEN protein into tumor cells as a promising strategy for cancer therapy via active albumin nanoparticles: A hypothesis11
A novel intrauterine barrier for preventing the recurrence of IUA after TCRA procedure10
NIoBReTH: A novel integrative paradigm of protection against SARS-CoV-2 and other airborne pathogens with fewer socioeconomic constraints10
Targeting survival without morbidity: Heart rate characteristics for oxygen supplementation optimization in neonatal care9
Are fungi responsible for the pathogenesis of oral lichen planus?9
Primary aldosteronism: A consequence of sugar and western Diet?9
Speechreading as a secondary diagnostic tool in bipolar disorder9
A new neonatal gastro-intestinal physiology-and pyloric stenosis of infancy a hypothesis9
Fighting arterial stiffness: A case for the importance of cardiorespiratory fitness in firefighters9
The use of negative oxygen ion clusters [O2−(H2O)n] and bicarbonate ions [HCO3−] as the supportive treatment of COVID-19 infections: A possibility8
Editorial Board8
Psilocybin to promote synaptogenesis in the brains of patients with mild cognitive impairment8
Activation of resident immune cells induces enteric neuronal death8
SIRT1-autophagy axis may inhibit oxidative stress-induced ferroptosis in human nucleus pulposus cells8
Chrono-regulation of AR-V7: A potential temporal driver of hormone resistance in prostate cancer?8
Amelioration of social impairments in autism: Possible role of vagal afferent stimulation in modification of the prefrontal-amygdala connectivity8
Retraction notice to “Facemasks in the COVID-19 era: A health hypothesis” [Medical Hypotheses 146 (2021) 5]8
Fundamental disincorporation and early non-inflammatory microglia alterations: Possible bridging phenomena between neurobiology and psychopathology in schizophrenia8
Exploring the link between sacral neuromodulation and body balance mechanism8
Insight into the possible therapeutic implication of the α-oxoaldehyde glyoxal in the treatment of viral infection7
Diaphragmatic speckle tracking imaging for 2D-strain assessment in mechanical ventilation weaning test7
Hypothesis on the potential of repetitive transcranial magnetic stimulation to modulate neurochemical pathways and circadian rhythm in ADHD7
Investigating myelin oligodendrocyte glycoprotein antibodies in hereditary citrullinemia7
Editorial Board7
Regular intake of vasodip (lercanidipine) relieves migraine attacks7
Multiple sclerosis, extra-mitochondrial energy production in myelin and transgenerational effects of lead exposure: Possible connections7
Periodontitis could affect functional connectivity in the brain leading to worsening of neuro psychiatric disorders – A hypothesis7
Phrenic nerve neurorrhaphy with a sural nerve graft in unilateral diaphragmatic paralysis7
Abulia is mediated by the neural pathways responsible for passivity symptoms with initiated actions remaining subject to conscious veto6
Transient Receptor Potential Vanilloid 1 (TRPV1) as a plausible novel therapeutic target for treating neurological complications in ZikaVirus6
BP-180-specific IgG antibodies: A potential useful candidate for early diagnosis of Bullous pemphigoid during anti-PD-1/anti-PDL-1 of melanoma patients6
Schizophrenia’s gene expression defies clarity: Insights from postmortem brain data6
Mitochondrial hijacking: A potential mechanism for SARS-CoV-2 to impair female fertility6
Why is the inferior aspect of the shoulder joint unprotected and weakest? A theory on brachiation and bipedalism6
Use of natural cysteine protease inhibitors in limiting SARS-Co-2 fusion into human respiratory cells6
Hypothesis for renin-angiotensin inhibitor mitigation of COVID-196
A novel hypothesis about abnormalities in ependymal ciliary cytoskeleton driving the development of syringomyelia-associated scoliosis and its potential mechanism6
Targeting the hypothalamic MC4 receptor: A novel approach to senolytic therapy?6
Models for SARS-CoV-2 associated thrombocytopenia associated with hemophagocytic histiocytes5
Highly expressed ACE-2 receptors during pregnancy: A protective factor for SARS-COV-2 infection?5
Could digoxin treat tachyarrhythmias in severe methylxanthine overdose?5
Tubular visual field defect relies on hyperbolic geometry spatial representations5
Vitamin D may prevent COVID-19 induced pregnancy complication5
Colonic mast cells trigger enteric neuronal death through the S100β/RAGE/NFκB pathway on inflammatory bowel diseases5
Assessing the structural and functional changes in vagus nerve in multiple sclerosis5
Age, obesity and hyperglycaemia: Activation of innate immunity initiates a series of molecular interactions involving anionic surfaces leading to COVID-19 morbidity and mortality5
Editorial Board5
Editorial Board5
Strategic combinatorial delivery of tranilast and paclitaxel using differently functionalized PLGA nanoparticles for enhanced penetration and accumulation in Breast tumor5
Far beyond experiments or myths – Medical Hypotheses is a provocative resource that helps students to think about science with criticism4
Low endogenous deoxyribonuclease activity in the colon as a factor contributing to the pathogenesis of ulcerative colitis4
Prolonged unexplained event might change an “unreliable perpetrator” into a “reliable resuscitator”4
Effects of biological clock on acute pancreatitis: Roles and mechanisms4
A promising method for reducing the incidence of diabetic foot ulcers: Regulating foot temperature during walking4
Pre-eclampsia and eclampsia pathogenesis utilizes iron released by a hemolytic protozoan parasite4
Bayesian interpretation of the hygiene hypothesis4
B cell receptor (BCR) guided mechanotransduction: Critical hypothesis to instruct SARS-CoV-2 specific B cells to trigger proximal signalling and antibody reshaping4
Pathological Demand Avoidance is a result of mental process opacity4
Snoring may transmit infectious aerosols from the upper to the lower respiratory tract4
Reply to: “Is there a genetic link between keratoconus and Fuch’s endothelial corneal dystrophy?”4
A theory on the pathogenesis of Leber hereditary optic neuropathy: Two hits and the role of light toxicity4
Crabtree effect as a parallel pathogenetic pathway in diabetic retinopathy4
A hypothesis exploring gender differences in gait variability using rhythmic auditory stimulation in individuals with Parkinson’s disease4
Platelet concentrates may affect the formation of pathological scars by regulating epithelial to mesenchymal transition4
Proposal for assessment of the predominant symptom and physical function in patients suffering from Long COVID4
Can human metapneumovirus infection be prevented by exercise?4
Does habitual squatting account for the ethnic difference in hip osteoarthritis?4
Corrigendum to “A hypothesis linking the Renin-Angiotensin, Kallikrein-Kinin systems, and disseminated coagulation in Covid-19” [Med. Hypothesis 192 (2024) 111488]4
Autophagy: A self-guard against SARS-CoV-24
Editorial Board4
Marginal BH4 deficiencies, iNOS, and self-perpetuating oxidative stress in post-acute sequelae of Covid-194
Hypothesis of subcortical visual pathway impairment in schizophrenia4
Could ancient Yamnaya dairying explain the environmental component of multiple sclerosis?4
WITHDRAWN: Elevated histamine etiology model for most major vaccine associated adverse events including SARS-CoV-2 spike vaccines4
Increased intracranial pressure due to chronic weight lifting exercises as a hypothesis of partial empty sella syndrome in an elite athlete4
Synergistic anticancer activity of Sulphoraphane and Teriflunomide co loaded lignin nanoparticles against triple negative breast cancer: Targeted nanoparticle delivery and drug repurposing3
Extending mental practice to sleep: Enhancing motor skills through lucid dreaming3
Acidic solution irrigation as a novel approach for treating infected walled-off pancreatic necrosis3
Alleviating morphine-induced itching while sustaining its analgesic efficacy: Esketamine as a potential co-administrating choice3
Transferosomal in situ gel administered through umbilical skin tissues for improved systemic bioavailability of drugs: A novel strategy to replace conventional transdermal route3
Supportive therapy during COVID-19: The proposed mechanism of short-chain fatty acids to prevent cytokine storm and multi-organ failure3
Potential circadian rhythms impacts on amblyopia treatment outcomes3
Glutamine addiction in virus-infected mammalian cells: A target of the innate immune system?3
Do ‘nature’ mediate stem cells empowerment in women?3
The Lazarus’ sign: A novel hypothesis on its hodology and neurophysiological mechanisms3
Editorial Board3
Estimate of benefit attributable to wearing masks in Chicago during the early days of the pandemic3
Attenuation of tryptophan metabolism by Fe chelators: A hypothesis regarding inhibiting tumor suppressive microenvironments in pancreatic ductal adenocarcinoma3
Fluoride as a potential contributory factor in pathogenesis of oral submucous fibrosis: A novel hypothesis3
Carpal, cubital or tarsal tunnel syndrome after SARS-CoV-2 infection: A causal link?3
Disease is essentially a biodiversity: A hypothesis3
Whole-body vibration combined with exercise may be more effective in lowering blood pressure and arterial stiffness than exercise alone in older adults with hypertension3
Adipocytes in obesity: A perfect reservoir for SARS-CoV-2?3
Central vs peripheral vascular factors determining risk of aortic dissection3
Intrathecal administration of clozapine to reduce side effects: A hypothesis3
Novel amino-acid based metal–organic frameworks (Bio-MOFs) as hemostatic agents: Unveiling promising frontiers in hemostasis3
“Chelation therapy applied to the treatment of oral Peri-implantitis: A hypothesis”3
Alzheimer’s disease is a result of loss of full brain buoyancy3
How fluency-enhancing conditions reduce stuttering. A unified explanation3
Why is the mesencephalic nucleus of the trigeminal nerve situated inside the brain?3
Pleasure and displeasure in self-mutilation: A hypothesis for opponent process theory?3
Glycemia and venous thromboembolism in patients with primary brain tumors – A speculative review3
Editorial Board3
l-Methionine may modulate the assembly of SARS-CoV-2 by interfering with the mechanism of RNA polymerase3
Progressive overload in cardiorespiratory exercise training for young and old: Is increasing duration or intensity of exercise more important?3
Prolactin and susceptibility to COVID-19 infection3
Can Bacillus Calmette-Guérin (BCG) treat localized prostate cancer?3
Regarding the paradox of increased coronary atherosclerosis among highly trained athletes: Might hepcidin be the culprit?3
Editorial Board3
Proximal fibular osteotomy as a treatment for degenerative meniscal extrusion3
Microglia harmonize the cerebral lymphoid system clearance in perioperative neurocognitive disorders by the ATP-AMP-ADO pathway3
Are fenestrations in peripheral pre-Descemet’s layer the route for intracameral air bubble migration during femtosecond LASIK?3
Molecular hydrogen as a potential adjuvant therapy for alleviating long COVID3
How the somatosensory system adapts to the motor change in Stroke: A hemispheric Shift?3
Erratum Regarding Previously Published Articles3
CCL2/ACKR2 interaction participate in breast cancer metastasis especially in patients with altered lipid metabolism3
Editorial Board3
Distinct contribution of monocarboxylate transporter 2 to infantile epileptic spasms syndrome3
The role of Natural Killer cells in pregnancy and their potential impact on cancer prevention3
Bayesian predictive coding hypothesis: Brain as observer’s key role in insight3
The concept of psychotic arousal and its relevance to abnormal subjective experiences in schizophrenia. A hypothesis for the formation of primary delusions3
Could fecal microbial transplantation offer a new potential in the treatment of metastatic pancreatic ductal adenocarcinoma?3
A hidden element governing immunogenicity in tumoral neoepitopes3
Correspondence to ’A quantum mechanical explanation for auditory-visual hallucinations by Liam Greenacre’3
Comment on: Central effects of Stellate Ganglion Block mediated by the vagus nerve? An alternate hypothesis for treating PTSD3
Editorial Board3
Tailored lipopeptide surfactants as potentially effective drugs to treat SARS-CoV-2 infection2
A bioengineered model for reinnervating the decellularized extracellular matrix of corneal scaffolds2
Could mosquito bites facilitate IgE sensitization to food and inhalant allergens?2
Does aberrant electrocortical dynamics pattern imply atypical balance control in adolescents with idiopathic scoliosis?2
Regular short exposures to cold environment as an adjunct therapy for patients with sleep apnea syndrome (SAS)2
Bridging the gap: Compressing non-unions for proper cellular signaling2
Erythrocyte enucleation in mammals is an anticancer mechanism: A hypothesis2
Hypothesis of immune homeostasis regulator: The nervous system regulates glucose immunometabolism to control immunity2
Nanoscale self-assembling prodrugs of sulfapyridine for treatment of arthritis: Harnessing the dual approach2
Beyond HbA1c: Can mitochondrial function assessment enhance evaluation of exercise efficacy?2
Adenosine deaminase and cytokines associated with infectious diseases as risk factors for inflammatory arthritis and methotrexate as a potential prophylactic agent2
Possible influence of neurosteroids in the anxiolytic effects of alpha-casozepine2
A hypothesis on the combination of platelet concentrates and adipocytes promoting wound healing through a bidirectional regulatory mechanism2
Amniotic extracelluar matrix microgels for attenuation of radiation-induced lung injury2
Is adiponectin deficiency a critical factor for sevoflurane induced neurocognitive dysfunction?2
Selenium deficiency and T-2 toxin trigger ferroptosis in cartilage from Kashin-Beck diseases2
Editorial Board2
Deregulated kynurenine metabolism – An alternate hypothesis for COVID-19 associated anosmia2
Intranasal interferon-beta as a promising alternative for the treatment of Alzheimer's disease2
Fibrosis-associated DDR1 downregulation contributes to a better prognosis in oral squamous cell carcinoma associated with oral submucous fibrosis2
Potential therapeutic agent for the treatment of retinal detachment: Artificial interphotoreceptor matrix2
When to intervene in aortic stenosis; can cardiac troponin I in the first morning urine be our guide?2
Reactive retinal vasodilation may mask capillary loss in eyes without diabetic retinopathy and isolated neurodegeneration2
Is vestibular migraine really a separate form of migraine?2
Topical metformin as a novel therapy for alopecia areata due to its immunologic effects2
Editorial Board2
The reverse zoonosis transfer cycle from the human-animal-plant-environment interface: How antibiotic-resistant bacteria from humans threaten the environment and fuel the rise of superbugs2
The potential role of fixation eye movements in the development of myopia2
Gut barrier dysfunction and type 2 immunity: Implications for compulsive behavior2
The uncoupled anterior and posterior spinal ligament tension (UAPLT) – An improvement to three-dimensional spring model of adolescent idiopathic scoliosis (AIS) pathogenesis2
A hypothesis to explain the potential influence of hormones on the severity of autism spectrum conditions in women2
What are the physiologic effects of Resistance Exercise behind breast cancer-related lymphedema prevention?2
Demethyleneberberine: A possible treatment for Huntington’s disease2
Heat shock protein 90, death-associated protein kinase 1 and other cold-induced proteins: Who’s to blame for cold-induced inflammasome activation in familial cold autoinflammatory syndromes?2
Hypothesis: Androgen receptor/Aurora A kinase/NF-κB signaling axis induce inflammatory response during polycystic ovarian syndrome progression2
The digestive Enzyme-Based nasal dysbiosis in Empty nose Syndrome: A theory2
The emerging concept of glycocalyx damage as the trigger of heart failure onset and progression2
Physical exercise and glycemic control: Is HbA1c the best marker for assessing the effects of aerobic training?2
Is paracetamol a neuroendocrine disruptor of the developing sexual brain?2
From treatment of mental disorders to the treatment of difficult life situations: A hypothesis and rationale2
Mesenchymal stromal cell extracellular vesicles: A possible strategy for prevention of preterm birth2
Applying radiofrequency energy to the penis in the treatment of erectile dysfunction2
Electrographic seizures possibly contribute to the epileptogenesis of acquired epilepsy2
Research in the pruritus of cholestasis: Genetics, behavioral studies, and physiomimetic interorgan models2
Ischaemic chondronecrosis as a novel causative factor in the aetiopathogenesis of infantile Blount’s disease2
The organ transplant recipient, a chimera subject, who develops a neoplastic lesion may be the suitable model to reconstruct the hierarchical organization of tumors2
A novel etiological approach for the development of knee osteoarthritis in sedentary adults2
Editorial Board2
Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication2
Role of ependymal cilia impairment in syringomyelia formation and its potential mechanism2
The mint versus Covid hypothesis2
Distinctive feeding vessel architecture and sparse collateralization may underlie the characteristic early temporal pole and external capsule white matter compromise in CADASIL2
Multi-drug loaded microneedles for emergency treatment of snakebite envenomation2
Editorial Board2
Möbius strip and cancer2
SARM1-mediated wallerian degeneration: A possible mechanism underlying organophosphorus-induced delayed neuropathy2
Retroviral synergy in oncogenesis via additive and cooperative protein actions and cross-reactivity of antiretroviral therapy2
Obesity paradox in acute myocardial infarction: Is plasminogen activator inhibitor 1 the culprit?2
Unveiling novel therapeutic avenues: Targeting the cyclin D/CDK4 axis for enhanced cancer treatment2
Comment on “Alleviating morphine-induced itching while sustaining its analgesic efficacy: Esketamine as a potential co-administrating choice”2
The maternal epigenome as a window into the in utero environment that the foetus experiences2
Beyond antibiotics: 3d-transition metal ions − serum albumin −indocyanine green complex as a novel multifunctional NIR-responsive therapeutic platform for treating diabetic foot ulcer2
The oncoprotective fever hypothesis: Have antibiotics, antimalarials and antipyrectics contributed to the global rise in cancer over the past century?2
Hypothesis: Platelet-rich plasma accelerate diabetic wound healing via dynamic modulation of multiple signaling pathways2
How were Lactobacillus species selected as single dominant species in the human vaginal microbiota? Coevolution of humans and Lactobacillus2
Are there medium to short-term multifaceted effects of the airborne pollutant PM2.5 determining the emergence of SARS-CoV-2 variants?2
Could neutrophil extracellular traps drive the development of autism?2
Time and the body: A new approach to disease2
Is Epstein Barr virus latency protective against type 1 diabetes?1
Can we reduce cancer progression via disrupting autophagy-cholesterol uptake nexus?1
Revolution of artificial intelligence in antimicrobial, anti-biofilm, and anti-inflammatory techniques: Smart photo-sonodynamic appliance in the internet of dental things (IoDT)1
Calcitonin gene-related peptide: A biomarker for stroke in SARS-CoV-2 infection?1
The synergistic potential of GLP-1R agonist dulaglutide and ghrelin receptor analogue anamorelin in ameliorating muscle atrophy1
What is the mechanism of loudness hyperacusis in autism?1
Traffic-derived metal bioaccumulation in bone tissue as a driver of osteoporosis1
Possible causes of vertigo attacks in Meniere’s disease1
The role of hemispheric sensory shifts: Impacts on stretch reflex and motor plasticity post-stroke1
Obstructive sleep apnea syndrome and life expectancy: Do pharyngeal evolutionary changes matter?1
High intelligence may exacerbate paediatric inflammatory response to SARS-CoV-2 infection1
Reducing fibrosis progression of biliary atresia by continuous administration of aducanumab at low dose: A potential treatment1
Multifaceted efficacy of caspofungin against fungal infections in COVID-19 patients1
Personalized repetitive transcranial magnetic stimulation guided by the spectral electroencephalogram may enhance and democratize therapy for autism spectrum disorder1
A hypotheses to explain acute adjustment disorder after phakic intraocular lens implantation in a highly myopic patient: Potential causes and suggested remedies1
Renin cell baroreceptor and arachidonic acid1
Exploring the role of mTOR signaling pathway in ketamine's therapeutic effects on suicide risk in depression: Insights into circadian dysregulation mechanisms1
Possible immune mechanisms initiated by 7-ketocholesterol that contribute to synovial oxidative stress and inflammation1
MALAT1: A novel hypothesis on the pathology of vascular injury in patients with β-thalassemia1
Response to: Obesity paradox in acute myocardial infarction: Is plasminogen activator inhibitor 1 the culprit?1
Is dream progression a Fibonacci spiral? A hypothesis1
Editorial Board1
Editorial Board1
Evolution of male-to-female oral sex as a detection tool of bacterial vaginosis and subsequent infertility1
Can atrial lead system ameliorate the diagnosis of atrial arrhythmias?1
Use of Nile tilapia fish skin in oral submucous fibrosis therapeutics1
Potential therapeutic effect of glucagon-like peptide-1 receptor agonists on COVID-19-induced pulmonary arterial hypertension1
Potential cellular intravesical therapy for non-muscle invasive bladder cancer: Nectin-4 targeted CAR-T cell therapy1
Proposal for adenomyosis classification based on the endometriosis phenotype1
Combatting future variants of SARS-CoV-2 using an in-silico peptide vaccine approach by targeting the spike protein1
Infrapatellar fat pad resection: A potential approach for slowing knee osteoarthritis progression1
Do circulating autoantibodies commonly found in healthy individuals reduce cancer risk?1
Editorial Board1
Reply to: “Is there a genetic link between Keratoconus and Fuch’s endothelial corneal dystrophy?”1
A one-step platform for screening high-efficient and minimal off-target CRISPR/Cas13 crRNAs to eradicate SARS-CoV-2 virus for treatment of COVID-19 patients1
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