Medical Hypotheses

Article	Citations
The hypothetical molecular pathways of ursolic acid to attenuate the premature ovarian failure in human	37
Exciter laser coronary atherectomy (ELCA) can be a powerful weapon in the treatment of chronic thromboembolic pulmonary hypertension (CTEPH)	30
Unraveling the impact of technology on immunological learning: What is the immune system listening to?	29
Long-term neurological implications of severe acute respiratory syndrome coronavirus 2 infections in neonates: Innate immune memory and chronic neuroinflammation	25
Editorial Board	23
Can virophages be used for management of viral infections?	22
A novel therapeutic approach for allergic rhinitis by exosome-mimetic nanovesicles derived from mesenchymal stem cells to restore nasal mucosal epithelial barrier	21
Stellate Ganglion Block may represent an effective therapeutic for Primary Sjögren’s Syndrome	20
Vaccine enhancement and improved immunogenicity using erythrocytes as carriers	20
Could cuproptosis be a novel therapeutic target for tooth eruption disturbances	19
A quantum mechanical explanation for auditory-visual hallucinations	18
Dynamic tissue distraction may enhance therapeutic efficacy for Critical limb ischemia	17
Post-adenoviral-based vaccines Guillain-Barre Syndrome: A proposed mechanism	15
Could sleep quality in pregnant women be related to developmental defects of enamel in children?	15
Protective effect of methylene blue in iron-induced neurotoxicity	15
Hypothesis: Hypermobile Ehlers Danlos Syndrome is a determinant of fetal and young infant bone strength	14
Delivery of PTEN protein into tumor cells as a promising strategy for cancer therapy via active albumin nanoparticles: A hypothesis	14
Combination therapy of curcumin and fecal microbiota transplant: Potential treatment of polycystic ovarian syndrome	14
The potential mechanisms of pain relief in patients after percutaneous vertebroplasty: Intravertebral pressure release and peripheral nerve ablation	13
Neuroinflammation as a possible link between attention-deficit/hyperactivity disorder (ADHD) and pain	13
Progesterone-induced blocking factor and interleukin 4 as novel therapeutics in the treatment of recurrent pregnancy loss	13
NIoBReTH: A novel integrative paradigm of protection against SARS-CoV-2 and other airborne pathogens with fewer socioeconomic constraints	12
Osteoclasts may play key roles in initiating biomaterial-induced ectopic bone formation	12
A novel intrauterine barrier for preventing the recurrence of IUA after TCRA procedure	11
Fighting arterial stiffness: A case for the importance of cardiorespiratory fitness in firefighters	11

Are fungi responsible for the pathogenesis of oral lichen planus?	10
Speechreading as a secondary diagnostic tool in bipolar disorder	10
Primary aldosteronism: A consequence of sugar and western Diet?	9
SIRT1-autophagy axis may inhibit oxidative stress-induced ferroptosis in human nucleus pulposus cells	9
Activation of resident immune cells induces enteric neuronal death	9
Retraction notice to “Facemasks in the COVID-19 era: A health hypothesis” [Medical Hypotheses 146 (2021) 5]	9
Targeting survival without morbidity: Heart rate characteristics for oxygen supplementation optimization in neonatal care	9
A new neonatal gastro-intestinal physiology-and pyloric stenosis of infancy a hypothesis	9
The use of negative oxygen ion clusters [O2−(H2O)n] and bicarbonate ions [HCO3−] as the supportive treatment of COVID-19 infections: A possibility	9
Fundamental disincorporation and early non-inflammatory microglia alterations: Possible bridging phenomena between neurobiology and psychopathology in schizophrenia	8
Amelioration of social impairments in autism: Possible role of vagal afferent stimulation in modification of the prefrontal-amygdala connectivity	8
Multiple sclerosis, extra-mitochondrial energy production in myelin and transgenerational effects of lead exposure: Possible connections	8
Exploring the link between sacral neuromodulation and body balance mechanism	8
Psilocybin to promote synaptogenesis in the brains of patients with mild cognitive impairment	8
Editorial Board	8
Periodontitis could affect functional connectivity in the brain leading to worsening of neuro psychiatric disorders – A hypothesis	7
Hypothesis for renin-angiotensin inhibitor mitigation of COVID-19	7
Targeting the hypothalamic MC4 receptor: A novel approach to senolytic therapy?	7
Phrenic nerve neurorrhaphy with a sural nerve graft in unilateral diaphragmatic paralysis	7
Insight into the possible therapeutic implication of the α-oxoaldehyde glyoxal in the treatment of viral infection	7
Regular intake of vasodip (lercanidipine) relieves migraine attacks	7
Diaphragmatic speckle tracking imaging for 2D-strain assessment in mechanical ventilation weaning test	7
Transient Receptor Potential Vanilloid 1 (TRPV1) as a plausible novel therapeutic target for treating neurological complications in ZikaVirus	7
Investigating myelin oligodendrocyte glycoprotein antibodies in hereditary citrullinemia	7
Editorial Board	7
Hypothesis on the potential of repetitive transcranial magnetic stimulation to modulate neurochemical pathways and circadian rhythm in ADHD	7
Why is the inferior aspect of the shoulder joint unprotected and weakest? A theory on brachiation and bipedalism	7
BP-180-specific IgG antibodies: A potential useful candidate for early diagnosis of Bullous pemphigoid during anti-PD-1/anti-PDL-1 of melanoma patients	6
Tubular visual field defect relies on hyperbolic geometry spatial representations	6
Vitamin D may prevent COVID-19 induced pregnancy complication	6
Mitochondrial hijacking: A potential mechanism for SARS-CoV-2 to impair female fertility	6
Use of natural cysteine protease inhibitors in limiting SARS-Co-2 fusion into human respiratory cells	6
Highly expressed ACE-2 receptors during pregnancy: A protective factor for SARS-COV-2 infection?	6
A novel hypothesis about abnormalities in ependymal ciliary cytoskeleton driving the development of syringomyelia-associated scoliosis and its potential mechanism	6
Abulia is mediated by the neural pathways responsible for passivity symptoms with initiated actions remaining subject to conscious veto	6
Age, obesity and hyperglycaemia: Activation of innate immunity initiates a series of molecular interactions involving anionic surfaces leading to COVID-19 morbidity and mortality	6
Can human metapneumovirus infection be prevented by exercise?	5
Could digoxin treat tachyarrhythmias in severe methylxanthine overdose?	5
Colonic mast cells trigger enteric neuronal death through the S100β/RAGE/NFκB pathway on inflammatory bowel diseases	5
Strategic combinatorial delivery of tranilast and paclitaxel using differently functionalized PLGA nanoparticles for enhanced penetration and accumulation in Breast tumor	5
Assessing the structural and functional changes in vagus nerve in multiple sclerosis	5
Models for SARS-CoV-2 associated thrombocytopenia associated with hemophagocytic histiocytes	5
Editorial Board	5
Reply to: “Is there a genetic link between keratoconus and Fuch’s endothelial corneal dystrophy?”	5
Editorial Board	5
Autophagy: A self-guard against SARS-CoV-2	4
Far beyond experiments or myths – Medical Hypotheses is a provocative resource that helps students to think about science with criticism	4
Editorial Board	4
Proposal for assessment of the predominant symptom and physical function in patients suffering from Long COVID	4
Are fenestrations in peripheral pre-Descemet’s layer the route for intracameral air bubble migration during femtosecond LASIK?	4

Bayesian interpretation of the hygiene hypothesis	4
Low endogenous deoxyribonuclease activity in the colon as a factor contributing to the pathogenesis of ulcerative colitis	4
Crabtree effect as a parallel pathogenetic pathway in diabetic retinopathy	4
Out of balance: the role of evolutionary mismatches in the sex disparity in autoimmune disease	4
A promising method for reducing the incidence of diabetic foot ulcers: Regulating foot temperature during walking	4
Pathological Demand Avoidance is a result of mental process opacity	4
A theory on the pathogenesis of Leber hereditary optic neuropathy: Two hits and the role of light toxicity	4
WITHDRAWN: Elevated histamine etiology model for most major vaccine associated adverse events including SARS-CoV-2 spike vaccines	4
Pre-eclampsia and eclampsia pathogenesis utilizes iron released by a hemolytic protozoan parasite	4
B cell receptor (BCR) guided mechanotransduction: Critical hypothesis to instruct SARS-CoV-2 specific B cells to trigger proximal signalling and antibody reshaping	4
Could ancient Yamnaya dairying explain the environmental component of multiple sclerosis?	4
Prolonged unexplained event might change an “unreliable perpetrator” into a “reliable resuscitator”	4
Corrigendum to “A hypothesis linking the Renin-Angiotensin, Kallikrein-Kinin systems, and disseminated coagulation in Covid-19” [Med. Hypothesis 192 (2024) 111488]	4
Effects of biological clock on acute pancreatitis: Roles and mechanisms	4
Does habitual squatting account for the ethnic difference in hip osteoarthritis?	4
Prolactin and susceptibility to COVID-19 infection	4
Increased intracranial pressure due to chronic weight lifting exercises as a hypothesis of partial empty sella syndrome in an elite athlete	4
Platelet concentrates may affect the formation of pathological scars by regulating epithelial to mesenchymal transition	4
Snoring may transmit infectious aerosols from the upper to the lower respiratory tract	4
Marginal BH4 deficiencies, iNOS, and self-perpetuating oxidative stress in post-acute sequelae of Covid-19	4
Hypothesis of subcortical visual pathway impairment in schizophrenia	4
How fluency-enhancing conditions reduce stuttering. A unified explanation	3
Adipocytes in obesity: A perfect reservoir for SARS-CoV-2?	3
Editorial Board	3
Alzheimer’s disease is a result of loss of full brain buoyancy	3
Attenuation of tryptophan metabolism by Fe chelators: A hypothesis regarding inhibiting tumor suppressive microenvironments in pancreatic ductal adenocarcinoma	3
l-Methionine may modulate the assembly of SARS-CoV-2 by interfering with the mechanism of RNA polymerase	3
Novel amino-acid based metal–organic frameworks (Bio-MOFs) as hemostatic agents: Unveiling promising frontiers in hemostasis	3
Carpal, cubital or tarsal tunnel syndrome after SARS-CoV-2 infection: A causal link?	3
Correspondence to ’A quantum mechanical explanation for auditory-visual hallucinations by Liam Greenacre’	3
Pleasure and displeasure in self-mutilation: A hypothesis for opponent process theory?	3
Editorial Board	3
Bayesian predictive coding hypothesis: Brain as observer’s key role in insight	3
Editorial Board	3
Microglia harmonize the cerebral lymphoid system clearance in perioperative neurocognitive disorders by the ATP-AMP-ADO pathway	3
Do ‘nature’ mediate stem cells empowerment in women?	3
Alleviating morphine-induced itching while sustaining its analgesic efficacy: Esketamine as a potential co-administrating choice	3
Erratum Regarding Previously Published Articles	3
Glycemia and venous thromboembolism in patients with primary brain tumors – A speculative review	3
Molecular hydrogen as a potential adjuvant therapy for alleviating long COVID	3
Why is the mesencephalic nucleus of the trigeminal nerve situated inside the brain?	3
Editorial Board	3
Synergistic anticancer activity of Sulphoraphane and Teriflunomide co loaded lignin nanoparticles against triple negative breast cancer: Targeted nanoparticle delivery and drug repurposing	3
A hidden element governing immunogenicity in tumoral neoepitopes	3
Estimate of benefit attributable to wearing masks in Chicago during the early days of the pandemic	3
Editorial Board	3
Can Bacillus Calmette-Guérin (BCG) treat localized prostate cancer?	3
Disease is essentially a biodiversity: A hypothesis	3
Supportive therapy during COVID-19: The proposed mechanism of short-chain fatty acids to prevent cytokine storm and multi-organ failure	3
Central vs peripheral vascular factors determining risk of aortic dissection	3
Extending mental practice to sleep: Enhancing motor skills through lucid dreaming	3
Acidic solution irrigation as a novel approach for treating infected walled-off pancreatic necrosis	3
Transferosomal in situ gel administered through umbilical skin tissues for improved systemic bioavailability of drugs: A novel strategy to replace conventional transdermal route	3
How the somatosensory system adapts to the motor change in Stroke: A hemispheric Shift?	3
Potential circadian rhythms impacts on amblyopia treatment outcomes	3
CCL2/ACKR2 interaction participate in breast cancer metastasis especially in patients with altered lipid metabolism	3
The role of Natural Killer cells in pregnancy and their potential impact on cancer prevention	3
Distinct contribution of monocarboxylate transporter 2 to infantile epileptic spasms syndrome	3
Progressive overload in cardiorespiratory exercise training for young and old: Is increasing duration or intensity of exercise more important?	3
Glutamine addiction in virus-infected mammalian cells: A target of the innate immune system?	3
Could fecal microbial transplantation offer a new potential in the treatment of metastatic pancreatic ductal adenocarcinoma?	3
The concept of psychotic arousal and its relevance to abnormal subjective experiences in schizophrenia. A hypothesis for the formation of primary delusions	3
Fluoride as a potential contributory factor in pathogenesis of oral submucous fibrosis: A novel hypothesis	3
Comment on: Central effects of Stellate Ganglion Block mediated by the vagus nerve? An alternate hypothesis for treating PTSD	3
Regarding the paradox of increased coronary atherosclerosis among highly trained athletes: Might hepcidin be the culprit?	3
Whole-body vibration combined with exercise may be more effective in lowering blood pressure and arterial stiffness than exercise alone in older adults with hypertension	3
Proximal fibular osteotomy as a treatment for degenerative meniscal extrusion	3
Erythrocyte enucleation in mammals is an anticancer mechanism: A hypothesis	3
Intrathecal administration of clozapine to reduce side effects: A hypothesis	3
“Chelation therapy applied to the treatment of oral Peri-implantitis: A hypothesis”	3
The Lazarus’ sign: A novel hypothesis on its hodology and neurophysiological mechanisms	3
The uncoupled anterior and posterior spinal ligament tension (UAPLT) – An improvement to three-dimensional spring model of adolescent idiopathic scoliosis (AIS) pathogenesis	2
A bioengineered model for reinnervating the decellularized extracellular matrix of corneal scaffolds	2
Amniotic extracelluar matrix microgels for attenuation of radiation-induced lung injury	2
Hypothesis: Platelet-rich plasma accelerate diabetic wound healing via dynamic modulation of multiple signaling pathways	2
Possible influence of neurosteroids in the anxiolytic effects of alpha-casozepine	2
Möbius strip and cancer	2
What are the physiologic effects of Resistance Exercise behind breast cancer-related lymphedema prevention?	2
The potential role of fixation eye movements in the development of myopia	2
Physical exercise and glycemic control: Is HbA1c the best marker for assessing the effects of aerobic training?	2

Editorial Board	2
Fibrosis-associated DDR1 downregulation contributes to a better prognosis in oral squamous cell carcinoma associated with oral submucous fibrosis	2
The mint versus Covid hypothesis	2
Tailored lipopeptide surfactants as potentially effective drugs to treat SARS-CoV-2 infection	2
Deregulated kynurenine metabolism – An alternate hypothesis for COVID-19 associated anosmia	2
From treatment of mental disorders to the treatment of difficult life situations: A hypothesis and rationale	2
The organ transplant recipient, a chimera subject, who develops a neoplastic lesion may be the suitable model to reconstruct the hierarchical organization of tumors	2
Are there medium to short-term multifaceted effects of the airborne pollutant PM2.5 determining the emergence of SARS-CoV-2 variants?	2
Multi-drug loaded microneedles for emergency treatment of snakebite envenomation	2
Reactive retinal vasodilation may mask capillary loss in eyes without diabetic retinopathy and isolated neurodegeneration	2
The maternal epigenome as a window into the in utero environment that the foetus experiences	2
The reverse zoonosis transfer cycle from the human-animal-plant-environment interface: How antibiotic-resistant bacteria from humans threaten the environment and fuel the rise of superbugs	2
Obesity paradox in acute myocardial infarction: Is plasminogen activator inhibitor 1 the culprit?	2
SARM1-mediated wallerian degeneration: A possible mechanism underlying organophosphorus-induced delayed neuropathy	2
Beyond HbA1c: Can mitochondrial function assessment enhance evaluation of exercise efficacy?	2
Unveiling novel therapeutic avenues: Targeting the cyclin D/CDK4 axis for enhanced cancer treatment	2
A hypothesis to explain the potential influence of hormones on the severity of autism spectrum conditions in women	2
The emerging concept of glycocalyx damage as the trigger of heart failure onset and progression	2
Intranasal interferon-beta as a promising alternative for the treatment of Alzheimer's disease	2
Hypothesis of immune homeostasis regulator: The nervous system regulates glucose immunometabolism to control immunity	2
Nanoscale self-assembling prodrugs of sulfapyridine for treatment of arthritis: Harnessing the dual approach	2
Mesenchymal stromal cell extracellular vesicles: A possible strategy for prevention of preterm birth	2
Bridging the gap: Compressing non-unions for proper cellular signaling	2
Research in the pruritus of cholestasis: Genetics, behavioral studies, and physiomimetic interorgan models	2
Potential therapeutic agent for the treatment of retinal detachment: Artificial interphotoreceptor matrix	2
How were Lactobacillus species selected as single dominant species in the human vaginal microbiota? Coevolution of humans and Lactobacillus	2
When to intervene in aortic stenosis; can cardiac troponin I in the first morning urine be our guide?	2
Applying radiofrequency energy to the penis in the treatment of erectile dysfunction	2
Regular short exposures to cold environment as an adjunct therapy for patients with sleep apnea syndrome (SAS)	2
Is paracetamol a neuroendocrine disruptor of the developing sexual brain?	2
Editorial Board	2
A novel etiological approach for the development of knee osteoarthritis in sedentary adults	2
Copper acetate aerosols: A possible tool complementary to vaccination in fight against SARS-CoV-2 and variants replication	2
Does aberrant electrocortical dynamics pattern imply atypical balance control in adolescents with idiopathic scoliosis?	2
Heat shock protein 90, death-associated protein kinase 1 and other cold-induced proteins: Who’s to blame for cold-induced inflammasome activation in familial cold autoinflammatory syndromes?	2
Gut barrier dysfunction and type 2 immunity: Implications for compulsive behavior	2
Selenium deficiency and T-2 toxin trigger ferroptosis in cartilage from Kashin-Beck diseases	2
Hypothesis: Androgen receptor/Aurora A kinase/NF-κB signaling axis induce inflammatory response during polycystic ovarian syndrome progression	2
Electrographic seizures possibly contribute to the epileptogenesis of acquired epilepsy	2
Adenosine deaminase and cytokines associated with infectious diseases as risk factors for inflammatory arthritis and methotrexate as a potential prophylactic agent	2
Beyond antibiotics: 3d-transition metal ions − serum albumin −indocyanine green complex as a novel multifunctional NIR-responsive therapeutic platform for treating diabetic foot ulcer	2
Editorial Board	2
Demethyleneberberine: A possible treatment for Huntington’s disease	2
A hypothesis on the combination of platelet concentrates and adipocytes promoting wound healing through a bidirectional regulatory mechanism	2
Time and the body: A new approach to disease	2
Could mosquito bites facilitate IgE sensitization to food and inhalant allergens?	2
The oncoprotective fever hypothesis: Have antibiotics, antimalarials and antipyrectics contributed to the global rise in cancer over the past century?	2
Role of ependymal cilia impairment in syringomyelia formation and its potential mechanism	2
Could neutrophil extracellular traps drive the development of autism?	2
Could SARS-CoV-2 blocking of ACE2 in endothelial cells result in upregulation of CX3CL1, promoting thrombosis in COVID-19 patients?	2
Is vestibular migraine really a separate form of migraine?	2
Ischaemic chondronecrosis as a novel causative factor in the aetiopathogenesis of infantile Blount’s disease	2
The role of carbohydrate antigen 125 in COVID-19	2
Distinctive feeding vessel architecture and sparse collateralization may underlie the characteristic early temporal pole and external capsule white matter compromise in CADASIL	2
Topical metformin as a novel therapy for alopecia areata due to its immunologic effects	2
Do prodrome symptoms influence multiple sclerosis disease course and severity?	2