OOIR: Observatory of International Research

Papers

(The H4-Index of Archives of Toxicology is 43. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite	1713
Investigating the applicability domain of the hiPSC-based PluriLum assay: an embryotoxicity assessment of chemicals and drugs	735
SIRT3/GLUT4 signaling activation by metformin protect against cisplatin-induced ototoxicity in vitro	510
miR-451a and miR-486-5p: biomarkers for benzene-induced hematotoxicity	333
Unraveling the Hsp70-ROS-autophagy axis in pentachlorophenol-challenged lung and liver epithelial cells	185
Sex-specific differences in toxicology: does the sex make the poison?	149
Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity	122
Exposure limits for indoor volatile substances concerning the general population: The role of population-based differences in sensory irritation of the eyes and airways for assessment factors	116
Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds—a hypo	106
Comprehensive ubiquitome analysis reveals persistent mitochondrial remodeling disruptions from doxorubicin-induced cardiotoxicity in aged CD-1 male mice	96
Optimized methods for measuring competitive binding of chemical substances to thyroid hormone distributor proteins transthyretin and thyroxine binding globulin	96
Influence of deoxynivalenol and zearalenone on the immunohistochemical expression of oestrogen receptors and liver enzyme genes in vivo in prepubertal gilts	93
7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells	93
Induction of clastogenesis and gene mutations by carbamazepine (at its therapeutically effective serum levels) in mammalian cells and the dependence on human CYP2B6 enzyme activity	90
Whole cigarette smoke condensates of heated tobacco products disrupt cell adhesion and induce anoikis in human bronchial epithelial cells	89
Biodistribution and pulmonary toxicity of branched polyethyleneimine in rats following intratracheal and intravenous exposure	82
Qualitative and quantitative in silico toxicity profiling of “angel dust”: phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE)	77
Cell–cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calcium	76
Neonatal opioid toxicity: opioid withdrawal (abstinence) syndrome with emphasis on pharmacogenomics and respiratory depression	76
Construction of testicular organoids and their applications in the field of toxicology	76
Impaired intestinal stem cell activity in ETEC infection: enterotoxins, cyclic nucleotides, and Wnt signaling	75
Single-cell RNA sequencing to reveal non-parenchymal cell heterogeneity and immune network of acetaminophen-induced liver injury in mice	74
Green tea catechins: protectors or threats to DNA? A review of their antigenotoxic and genotoxic effects	73
A modular strategy for the testing and assessment of non-genotoxic carcinogens	71
Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice	70

Whether aristolochic acid directly drives hepatocarcinogenesis: comprehensive investigations from mutational signatures to animal models	67
Developmental brain lipidomics is influenced by postnatal chlorpyrifos exposure and APOE genetic background in mice	67
The role of redox signaling in mitochondria and endoplasmic reticulum regulation in kidney diseases	67
In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity	64
In vitro-in silico analysis reveals that loss of tankyrase1/2 improves bile acid handling in genetically engineered HepG2 cultures	63
In silico structural and mechanistic sights into the N-glycosidase mechanism of Shiga toxin	60
Combined use of multiparametric high-content-screening and in vitro circadian reporter assays in neurotoxicity evaluation	57
Development of a transcriptome-based determination of innate immune suppressor (TDIS) assay as an in vitro test for immunotoxicity	57
Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to 2- and 3-monochloropropanediol (urinary excretion) and glycidol (hemoglob	57
Dipyanone, a new methadone-like synthetic opioid: In vitro and in vivo human metabolism and pharmacological profiling	56
Dimethyltryptamine and harmine, components of ayahuasca, prevented cocaine-induced apoptosis in SH-SY5Y human neuroblastoma cells	55
Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects	52
Quantitative genotoxicity assessment of N-nitrosodimethylamine in mice by error-corrected next-generation sequencing and DNA methylation quantification for toxicity threshold determination	50
Nε-(1-Carboxymethyl)-L-lysine, an advanced glycation end product, exerts malignancy on chondrosarcoma via the activation of cancer stemness	49
Application of physiologically based (PBK) modeling to quantify the effect of the antibiotic tobramycin on bile acid levels in human plasma	48
Identification, synthesis and quantification of eutylone consumption markers in a chemsex context	48
Canine coronavirus infection is intensified by 2,3,7,8-tetrachlorodibenzo-p-dioxin	48
ITGA1, the alpha 1 subunit of integrin receptor, is a novel marker of drug-resistant senescent melanoma cells in vitro	44
Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models	43