OOIR: Observatory of International Research

Papers

(The H4-Index of Archives of Toxicology is 42. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Induction of clastogenesis and gene mutations by carbamazepine (at its therapeutically effective serum levels) in mammalian cells and the dependence on human CYP2B6 enzyme activity	1516
NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite	624
Construction of testicular organoids and their applications in the field of toxicology	426
A modular strategy for the testing and assessment of non-genotoxic carcinogens	222
Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice	166
Whether aristolochic acid directly drives hepatocarcinogenesis: comprehensive investigations from mutational signatures to animal models	135
Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds—a hypo	110
The role of redox signaling in mitochondria and endoplasmic reticulum regulation in kidney diseases	105
7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells	95
Comprehensive ubiquitome analysis reveals persistent mitochondrial remodeling disruptions from doxorubicin-induced cardiotoxicity in aged CD-1 male mice	92
Impaired intestinal stem cell activity in ETEC infection: enterotoxins, cyclic nucleotides, and Wnt signaling	88
SIRT3/GLUT4 signaling activation by metformin protect against cisplatin-induced ototoxicity in vitro	86
miR-451a and miR-486-5p: biomarkers for benzene-induced hematotoxicity	85
Unraveling the Hsp70-ROS-autophagy axis in pentachlorophenol-challenged lung and liver epithelial cells	84
Sex-specific differences in toxicology: does the sex make the poison?	77
Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity	72
Influence of deoxynivalenol and zearalenone on the immunohistochemical expression of oestrogen receptors and liver enzyme genes in vivo in prepubertal gilts	72
Exposure limits for indoor volatile substances concerning the general population: The role of population-based differences in sensory irritation of the eyes and airways for assessment factors	71
Green tea catechins: protectors or threats to DNA? A review of their antigenotoxic and genotoxic effects	70
Neonatal opioid toxicity: opioid withdrawal (abstinence) syndrome with emphasis on pharmacogenomics and respiratory depression	70
Cell–cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calcium	69
Optimized methods for measuring competitive binding of chemical substances to thyroid hormone distributor proteins transthyretin and thyroxine binding globulin	68
Single-cell RNA sequencing to reveal non-parenchymal cell heterogeneity and immune network of acetaminophen-induced liver injury in mice	66
Investigating the applicability domain of the hiPSC-based PluriLum assay: an embryotoxicity assessment of chemicals and drugs	63
Developmental brain lipidomics is influenced by postnatal chlorpyrifos exposure and APOE genetic background in mice	62

In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity	60
Identification, synthesis and quantification of eutylone consumption markers in a chemsex context	59
In vitro-in silico analysis reveals that loss of tankyrase1/2 improves bile acid handling in genetically engineered HepG2 cultures	55
N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen β-naphthylamine in cryopreserved human hepatocytes	54
Application of physiologically based (PBK) modeling to quantify the effect of the antibiotic tobramycin on bile acid levels in human plasma	54
Nε-(1-Carboxymethyl)-L-lysine, an advanced glycation end product, exerts malignancy on chondrosarcoma via the activation of cancer stemness	53
Canine coronavirus infection is intensified by 2,3,7,8-tetrachlorodibenzo-p-dioxin	53
Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects	50
Quantitative genotoxicity assessment of N-nitrosodimethylamine in mice by error-corrected next-generation sequencing and DNA methylation quantification for toxicity threshold determination	50
Evaluation of the toxicity of combustion smokes at the air–liquid interface: a comparison between two lung cell models and two exposure methods	49
Coenzyme Q0 defeats NLRP3-mediated inflammation, EMT/metastasis, and Warburg effects by inhibiting HIF-1α expression in human triple-negative breast cancer cells	48
Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to 2- and 3-monochloropropanediol (urinary excretion) and glycidol (hemoglob	46
In silico structural and mechanistic sights into the N-glycosidase mechanism of Shiga toxin	46
Development of a transcriptome-based determination of innate immune suppressor (TDIS) assay as an in vitro test for immunotoxicity	46
What do we currently know about Novichoks? The state of the art	43
Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)	43
ITGA1, the alpha 1 subunit of integrin receptor, is a novel marker of drug-resistant senescent melanoma cells in vitro	43
Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS	42
Toxicokinetics of benzotriazole UV stabilizer UV-P in humans after single oral administration	42
Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models	42