Intensive Care Medicine

Article	Citations
High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study	2032
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021	1547
Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study	551
Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#	505
European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care	467
Acute kidney injury in critically ill patients with COVID-19	359
Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis	338
Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion	272
Managing ICU surge during the COVID-19 crisis: rapid guidelines	265
Prone position in ARDS patients: why, when, how and for whom	246
Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS	245
Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study	224
ECMO for severe ARDS: systematic review and individual patient data meta-analysis	215
The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline	178
Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis	177
Prediction of poor neurological outcome in comatose survivors of cardiac arrest: a systematic review	176
What’s new in lung ultrasound during the COVID-19 pandemic	174
Lung ultrasound predicts clinical course and outcomes in COVID-19 patients	163
Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial	162
Acute kidney injury in the critically ill: an updated review on pathophysiology and management	156
Analgesia and sedation in patients with ARDS	154
Physiological and quantitative CT-scan characterization of COVID-19 and typical ARDS: a matched cohort study	153
Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19	147
Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysis	146
Epidemiology and burden of sepsis acquired in hospitals and intensive care units: a systematic review and meta-analysis	145

Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus	138
How the COVID-19 pandemic will change the future of critical care	137
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies	136
COVID-19 increased the risk of ICU-acquired bloodstream infections: a case–cohort study from the multicentric OUTCOMEREA network	123
Comparative study of lung ultrasound and chest computed tomography scan in the assessment of severity of confirmed COVID-19 pneumonia	121
Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS	116
Understanding pathophysiology of hemostasis disorders in critically ill patients with COVID-19	115
Lung ultrasound for the early diagnosis of COVID-19 pneumonia: an international multicenter study	114
Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study	112
Access to intensive care in 14 European countries: a spatial analysis of intensive care need and capacity in the light of COVID-19	110
Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications	110
Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis	108
Moving from bytes to bedside: a systematic review on the use of artificial intelligence in the intensive care unit	108
COVID-19 in critical care: epidemiology of the first epidemic wave across England, Wales and Northern Ireland	107
Phenotypes and personalized medicine in the acute respiratory distress syndrome	105
Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study	103
Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort	103
Use of nasal high flow oxygen during acute respiratory failure	101
Delirium in critical illness: clinical manifestations, outcomes, and management	99
Extracorporeal life support for adults with acute respiratory distress syndrome	99
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study	98
Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial	90
Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients	89
ERC-ESICM guidelines on temperature control after cardiac arrest in adults	88
Intensive care unit acquired muscle weakness in COVID-19 patients	87
Neurofilament light as an outcome predictor after cardiac arrest: a post hoc analysis of the COMACARE trial	87
Prediction of outcome of nasal high flow use during COVID-19-related acute hypoxemic respiratory failure	87
Basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population: consensus and expert recommendations of the European Society of Intensive Care Medicine	84
Expanding controlled donation after the circulatory determination of death: statement from an international collaborative	84
Tocilizumab and remdesivir in hospitalized patients with severe COVID-19 pneumonia: a randomized clinical trial	84
ECMO for COVID-19 patients in Europe and Israel	82
Bleeding and thrombotic events in adults supported with venovenous extracorporeal membrane oxygenation: an ELSO registry analysis	81
Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS	78
Bacterial and fungal superinfections in critically ill patients with COVID-19	76
Invasive candidiasis in critical care: challenges and future directions	75
Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial	72
Low-dose methylprednisolone treatment in critically ill patients with severe community-acquired pneumonia	72
Early bacterial co-infection in ARDS related to COVID-19	72
Pericyte alteration sheds light on micro-vasculopathy in COVID-19 infection	72
Neuromuscular blockade in patients with ARDS: a rapid practice guideline	71
Pulmonary infections complicating ARDS	71
Frailty index predicts poor outcome in COVID-19 patients	70
Prediction of good neurological outcome in comatose survivors of cardiac arrest: a systematic review	68
The PRICES statement: an ESICM expert consensus on methodology for conducting and reporting critical care echocardiography research studies	66
Systemic arterial thrombosis and acute mesenteric ischemia in a patient with COVID-19	66
Evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months	65
Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets	63
Management of moderate to severe traumatic brain injury: an update for the intensivist	61
Severe COVID-19 is associated with deep and sustained multifaceted cellular immunosuppression	61
Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial	61

Performance of a guideline-recommended algorithm for prognostication of poor neurological outcome after cardiac arrest	61
Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis	61
How can assessing hemodynamics help to assess volume status?	61
Fluid administration and monitoring in ARDS: which management?	60
Echocardiography findings in COVID-19 patients admitted to intensive care units: a multi-national observational study (the ECHO-COVID study)	59
How to ventilate obese patients in the ICU	59
Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset	57
Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis	57
Current and evolving standards of care for patients with ARDS	56
Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study	56
Intracranial pressure: current perspectives on physiology and monitoring	56
Efficacy of early prone position for COVID-19 patients with severe hypoxia: a single-center prospective cohort study	56
Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest	55
Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study	55
Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial	53
Etomidate versus ketamine for emergency endotracheal intubation: a randomized clinical trial	53
Lung ultrasonography versus chest CT in COVID-19 pneumonia: a two-centered retrospective comparison study from China	52
Dexmedetomidine vs other sedatives in critically ill mechanically ventilated adults: a systematic review and meta-analysis of randomized trials	51
Current practice and evolving concepts in septic shock resuscitation	51
Emerging pharmacological therapies for ARDS: COVID-19 and beyond	50
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia	50
Palliative care interventions in intensive care unit patients	50
Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials	49
How to use biomarkers of infection or sepsis at the bedside: guide to clinicians	48
Hospital mortality in mechanically ventilated COVID-19 patients in Mexico	48
Ten reasons for focusing on the care we provide for family members of critically ill patients with COVID-19	47
Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom	46
Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial	45
Interventions for oropharyngeal dysphagia in acute and critical care: a systematic review and meta-analysis	45
Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine	44
Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials	44
Machine learning in intensive care medicine: ready for take-off?	44
Is severe COVID-19 pneumonia a typical or atypical form of ARDS? And does it matter?	43
ICU capacity management during the COVID-19 pandemic using a process simulation	43
Randomised clinical trials in critical care: past, present and future	43
Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial	43
Effect of prone positioning on survival in adult patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis	43
IL-6 may be a good biomarker for earlier detection of COVID-19 progression	43
Cytomegalovirus blood reactivation in COVID-19 critically ill patients: risk factors and impact on mortality	43
Survival benefit of extracorporeal membrane oxygenation in severe COVID-19: a multi-centre-matched cohort study	43
Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study	43
Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial	42
Diagnosis and treatment of COVID-19 associated pulmonary apergillosis in critically ill patients: results from a European confederation of medical mycology registry	42
Clinical phenotypes of critically ill COVID-19 patients	42
Plasma exchange in the intensive care unit: a narrative review	42
Role of total lung stress on the progression of early COVID-19 pneumonia	41
High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial	41
Adjuvant therapeutic plasma exchange in septic shock	41
Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial	40
Development and validation of novel sepsis subphenotypes using trajectories of vital signs	40
Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial	40
Antiseptic mouthwash, the nitrate–nitrite–nitric oxide pathway, and hospital mortality: a hypothesis generating review	40
Mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia	39
The negative impact of comorbidities on the disease course of COVID-19	39
Respiratory indications for ECMO: focus on COVID-19	39
Paediatric Inflammatory Multisystem Syndrome Temporally-Associated with SARS-CoV-2 Infection: An Overview	38
Gender differences in the provision of intensive care: a Bayesian approach	38
Moral distress in the intensive care unit during the pandemic: the burden of dying alone	38
Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial	38
Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study	38
Hemoperfusion in the intensive care unit	38
Impact of frailty on persistent critical illness: a population-based cohort study	38
Respiratory microbiome in mechanically ventilated patients: a narrative review	37
Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge c	37
Everything you need to know about deresuscitation	37
Conservative oxygen therapy for mechanically ventilated adults with suspected hypoxic ischaemic encephalopathy	37
Implementation of new ECMO centers during the COVID-19 pandemic: experience and results from the Middle East and India	37
The baby lung and the COVID-19 era	37
Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial	37
Bleeding and thrombotic events in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study	37
Inhalational volatile-based sedation for COVID-19 pneumonia and ARDS	37
Pulmonary immuno-thrombosis in COVID-19 ARDS pathogenesis	36
Cytokine adsorption in severe, refractory septic shock	36
Monitoring of high-flow nasal cannula for SARS-CoV-2 severe pneumonia: less is more, better look at respiratory rate	36
Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study	36
External validation of prognostic scores for COVID-19: a multicenter cohort study of patients hospitalized in Greater Paris University Hospitals	36
Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial	35
Mechanical power and driving pressure as predictors of mortality among patients with ARDS	35
Recognizing and supporting morally injured ICU professionals during the COVID-19 pandemic	35
Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia	35

The ten reasons why corticosteroid therapy reduces mortality in severe COVID-19	35
Between-centre differences for COVID-19 ICU mortality from early data in England	33
Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients	33
Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study	32
Extubation in neurocritical care patients: the ENIO international prospective study	32
Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients: a CENTER-TBI study	32
Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis	32
Designing an ARDS trial for 2020 and beyond: focus on enrichment strategies	32
Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study	32
Critical illness in patients with hematologic malignancy: a population-based cohort study	32
Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis	32
Trends in clinical profiles, organ support use and outcomes of patients with cancer requiring unplanned ICU admission: a multicenter cohort study	32
Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: an updated systematic review and network meta-analysis of randomized trials	31
Factors associated with acute mesenteric ischemia among critically ill ventilated patients with shock: a post hoc analysis of the NUTRIREA2 trial	31
Correction to: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS	31
Mental health symptoms in family members of COVID-19 ICU survivors 3 and 12 months after ICU admission: a multicentre prospective cohort study	30
Myorelaxants in ARDS patients	30
Neuroanatomical substrates of generalized brain dysfunction in COVID-19	30
Prothrombotic phenotype in COVID-19 severe patients	30
Stages or phenotypes? A critical look at COVID-19 pathophysiology	29
How to improve intubation in the intensive care unit. Update on knowledge and devices	29
SARS-CoV-2 viral loads and serum IgA/IgG immune responses in critically ill COVID-19 patients	28
Ten things we learned about COVID-19	28
Echocardiography phenotypes of right ventricular involvement in COVID-19 ARDS patients and ICU mortality: post-hoc (exploratory) analysis of repeated data from the ECHO-COVID study	28
Electroencephalogram in the intensive care unit: a focused look at acute brain injury	28
How to manage anticoagulation during extracorporeal membrane oxygenation	28
Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted norm	28
Neurally adjusted ventilatory assist in acute respiratory failure: a randomized controlled trial	28
Feasibility of conservative fluid administration and deresuscitation compared with usual care in critical illness: the Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) randomised clinica	28
Rapidly scalable mechanical ventilator for the COVID-19 pandemic	27
Epinephrine versus norepinephrine in cardiac arrest patients with post-resuscitation shock	27
Long-term mortality of elderly patients after intensive care unit admission for COVID-19	27
Management and outcomes of pregnant women admitted to intensive care unit for severe pneumonia related to SARS-CoV-2 infection: the multicenter and international COVIDPREG study	27
Predictors of death and new disability after critical illness: a multicentre prospective cohort study	27
COVID-19 associated pulmonary aspergillosis: regional variation in incidence and diagnostic challenges	26
How to ventilate obstructive and asthmatic patients	26
Glucocorticoids inhibit type I IFN beta signaling and the upregulation of CD73 in human lung	26
Veno-venous extracorporeal membrane oxygenation (vv-ECMO) for severe respiratory failure in adult cancer patients: a retrospective multicenter analysis	26
Intensive care for COVID-19 in low- and middle-income countries: research opportunities and challenges	25
Long term outcomes of critically ill COVID-19 pneumonia patients: early learning	25
The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis	25
Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury	25
Potential role for interferon gamma in the treatment of recurrent ventilator-acquired pneumonia in patients with COVID-19: a hypothesis	24
Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-19	24
Health-related quality of life in survivors of septic shock: 6-month follow-up from the ADRENAL trial	24
The association of the COVID-19 pandemic and short-term outcomes of non-COVID-19 critically ill patients: an observational cohort study in Brazilian ICUs	24
Ultrasound assessment of pulmonary fibroproliferative changes in severe COVID-19: a quantitative correlation study with histopathological findings	24
Monitoring cerebral oxygenation in acute brain-injured patients	24
(1 → 3)-β-d-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial	24
Admission chest CT score predicts 5-day outcome in patients with COVID-19	24
Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures	23
Proportional modes of ventilation: technology to assist physiology	23
Hospital-level variation in the development of persistent critical illness	23
Safety and efficacy of multipotent adult progenitor cells in acute respiratory distress syndrome (MUST-ARDS): a multicentre, randomised, double-blind, placebo-controlled phase 1/2 trial	23
Understanding post-COVID-19 interstitial lung disease (ILD): a new fibroinflammatory disease entity	22
Organizational aspects of care associated with mortality in critically ill COVID-19 patients	22
Impact of late administration of corticosteroids in COVID-19 ARDS	22
SARS-CoV-2 in carotid body	22
Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline	22
Critically ill patients with COVID-19: are they hemodynamically unstable and do we know why?	22
Discriminating between CPAP success and failure in COVID-19 patients with severe respiratory failure	22
Increased mortality in patients with COVID-19 receiving extracorporeal respiratory support during the second wave of the pandemic	22
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study	22
Sepsis hospitalization and risk of subsequent cardiovascular events in adults: a population-based matched cohort study	21
The prevalence, risk factors and outcome of cardiac dysfunction in hospitalized patients with COVID-19	21
How to manage coagulopathies in critically ill patients	21
Artificial intelligence in intensive care medicine	21
Early and sustained Lactobacillus plantarum probiotic therapy in critical illness: the randomised, placebo-controlled, restoration of gut microflora in critical illness trial (ROCIT)	21
Ten myths about albumin	21
What’s new in ECMO for COVID-19?	20
Effect of postextubation noninvasive ventilation with active humidification vs high-flow nasal cannula on reintubation in patients at very high risk for extubation failure: a randomized trial	20
Cardiac injury in COVID-19	20
Poor quality data, privacy, lack of certifications: the lethal triad of new technologies in intensive care	20
ICU scoring systems	20
Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90s?	20
Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial	20
COVID-19: what the clinician should know about post-mortem findings	20
Differential pathophysiologic phenotypes of hypoxic ischemic brain injury: considerations for post-cardiac arrest trials	20
Contrast-enhanced ultrasound (CEUS) of the lung reveals multiple areas of microthrombi in a COVID-19 patient	20
ERC-ESICM guidelines for prognostication after cardiac arrest: time for an update	20
Association of patient-to-intensivist ratio with hospital mortality in Australia and New Zealand	20
Direct assessment of microcirculation in shock: a randomized-controlled multicenter study	19
Monitoring patient–ventilator interaction by an end-expiratory occlusion maneuver	19
Sepsis-associated acute kidney injury in the intensive care unit: incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes. A multicenter, observational study	19
Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit	19
Aerobic exercise capacity in long-term survivors of critical illness: secondary analysis of the post-EPaNIC follow-up study	19
Source control in the management of sepsis and septic shock	19
Integrative omics provide biological and clinical insights into acute respiratory distress syndrome	19
Airborne spread of SARS-CoV-2 while using high-flow nasal cannula oxygen therapy: myth or reality?	19
ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children— a systematic review and meta-analysis	18
The AKI care bundle: all bundle components are created equal—are they?	18
Camostat mesylate therapy in critically ill patients with COVID-19 pneumonia	18
Time to intra-arrest therapeutic hypothermia in out-of-hospital cardiac arrest patients and its association with neurologic outcome: a propensity matched sub-analysis of the PRINCESS trial	18
Prognostic relevance and inter-observer reliability of chest-imaging in pediatric ARDS: a pediatric acute respiratory distress incidence and epidemiology (PARDIE) study	18
High-level burnout in physicians and nurses working in adult ICUs: a systematic review and meta-analysis	18