OOIR: Observatory of International Research

Papers

(The median citation count of Drug Metabolism Reviews is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
The annoying flaws of gerontological research	42
Drug transporters in drug disposition – the year 2022 in review	33
Cell-Biomaterial constructs for wound healing and skin regeneration	29
Enantioselectivity in some physiological and pathophysiological roles of hydroxyeicosatetraenoic acids	28
Differential modulation of cytochrome P450 enzymes by arsenicals in non-human experimental models	25
New strategy for rational use of antihypertensive drugs in clinical practice in high-altitude hypoxic environments	19
Bioanalytical strategies in drug discovery and development	19
An in-depth review of PPARγ modulators as anti-diabetes therapeutics	18
Mechanisms of intestinal pharmacokinetic natural product-drug interactions	17
Cytochrome P450-mediated carbon-carbon bond formation in drug metabolism	15
Assessing and mitigating pH-mediated DDI risks in drug development – formulation approaches and clinical considerations	14
Biopolymers as promising vehicles for drug delivery to the brain	13
Rodent genetic models of Ah receptor signaling	13
Transporter-mediated drug-drug interactions: regulatory guidelines, in vitro and in vivo methodologies and translation, special population	12
Genetic determinants of paclitaxel-induced peripheral neuropathy: a review of current literature	12
Metabolic activation of tyrosine kinase inhibitors: recent advance and further clinical practice	12
Clinical pharmacokinetics of nebivolol: a systematic review	11
Scaling factors to inform in vitro - in vivo extrapolation from preclinical and livestock animals: state of the field and recommendations	11
Favipiravir, remdesivir, and lopinavir: metabolites, degradation products and their analytical methods	10
Recent advances in drug transporter sciences: highlights from the year 2020	10
In silico ADME and target prediction studies of Alogliptin as drug molecule	10
A transcriptional regulatory network of HNF4α and HNF1α involved in human diseases and drug metabolism	10
Impact of DNA methylation on ADME gene expression, drug disposition, and efficacy	9
Reinforcing our defense or weakening the enemy? A comparative overview of defensive and offensive strategies developed to confront COVID-19	8
Effects of intestinal flora on pharmacokinetics and pharmacodynamics of drugs	7

Advances in drug resistance of osteosarcoma caused by pregnane X receptor	7
Drug metabolic stability in early drug discovery to develop potential lead compounds	6
Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development	6
The relationship between UGT1A1 gene & various diseases and prevention strategies	5
In-depth understanding of the structure-based reactive metabolite formation of organic functional groups	5
Biotransformation research advances – 2023 year in review	5
Metabolism of m -CPP, trazodone, nefazodone, and etoperidone: clinical and forensic aspects	4
Relationship between blood–brain barrier changes and drug metabolism under high-altitude hypoxia: obstacle or opportunity for drug transport?	4
The multifaceted role of cytochrome P450-Derived arachidonic acid metabolites in diabetes and diabetic cardiomyopathy	4
Ocular drug-metabolizing enzymes: focus on esterases	4
Physiological and pathophysiological roles of hepoxilins and their analogs	4
Interaction of drugs with gut microbiota modulators	4
Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms	4
Regulation of human UDP-glycosyltransferase (UGT) genes by miRNAs	4
3D self-assembled nanocarriers for drug delivery	4
Melatonin in cancer biology: pathways, derivatives, and the promise of targeted delivery	4
Cutting-edge strategies and critical advancements in characterization and quantification of metabolites concerning translational metabolomics	4
Bioactivation and reactivity research advances – 2021 year in review	3
The aminosalicylate - folate connection	3
Drug transporters in drug disposition – highlights from the year 2023	3
Effect of inflammation on cytochrome P450-mediated arachidonic acid metabolism and the consequences on cardiac hypertrophy	3
Enzyme-mediated drug-drug interactions: a review of in vivo and in vitro methodologies, regulatory guidance, and translation to the clinic	3
The role and current research status of resveratrol in the treatment of osteoarthritis and its mechanisms: a narrative review	3
Effects of cannabidiol and Δ ⁹ -tetrahydrocannabinol on cytochrome P450 enzymes: a systematic review	3
The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure	3