OOIR: Observatory of International Research

Papers

(The median citation count of Drug Metabolism Reviews is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
The annoying flaws of gerontological research	45
Drug transporters in drug disposition – the year 2022 in review	45
Cell-Biomaterial constructs for wound healing and skin regeneration	34
CYP24A1: The Pivotal Regulator of Vitamin D Homeostasis, Pathophysiology in Metabolic and Genetic Disease, and Emerging Target for Precision Medicine	28
New strategy for rational use of antihypertensive drugs in clinical practice in high-altitude hypoxic environments	27
Differential modulation of cytochrome P450 enzymes by arsenicals in non-human experimental models	25
Phase II metabolism in xenobiotic biotransformation: general mechanisms and the underestimated role of microbial systems	21
An in-depth review of PPARγ modulators as anti-diabetes therapeutics	19
Mechanisms of intestinal pharmacokinetic natural product-drug interactions	17
Enantioselectivity in some physiological and pathophysiological roles of hydroxyeicosatetraenoic acids	16
Multimolecular interactions from Chinese medicines activate nuclear receptor conformational changes: a potential strategy for anti-inflammatory therapy	15
Cytochrome P450-mediated carbon-carbon bond formation in drug metabolism	15
Transporter-mediated drug-drug interactions: regulatory guidelines, in vitro and in vivo methodologies and translation, special population	14
Biopolymers as promising vehicles for drug delivery to the brain	14
Drug transporters in drug disposition – highlights from the year 2024	14
Assessing and mitigating pH-mediated DDI risks in drug development – formulation approaches and clinical considerations	14
Metabolism of new drug modalities research advances – 2024 year in review	12
Genetic determinants of paclitaxel-induced peripheral neuropathy: a review of current literature	12
Clinical pharmacokinetics of nebivolol: a systematic review	11
Scaling factors to inform in vitro - in vivo extrapolation from preclinical and livestock animals: state of the field and recommendations	11
A transcriptional regulatory network of HNF4α and HNF1α involved in human diseases and drug metabolism	11
Metabolic activation of tyrosine kinase inhibitors: recent advance and further clinical practice	10
Favipiravir, remdesivir, and lopinavir: metabolites, degradation products and their analytical methods	9
In silico ADME and target prediction studies of Alogliptin as drug molecule	9
Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development	8

In-depth understanding of the structure-based reactive metabolite formation of organic functional groups	8
Advances in drug resistance of osteosarcoma caused by pregnane X receptor	8
Correction	8
Impact of DNA methylation on ADME gene expression, drug disposition, and efficacy	8
Effects of intestinal flora on pharmacokinetics and pharmacodynamics of drugs	8
Biotransformation research advances – 2023 year in review	7
Analytical techniques for methyldopa and metabolites: a comprehensive review	6
Melatonin in cancer biology: pathways, derivatives, and the promise of targeted delivery	6
Metabolism of m -CPP, trazodone, nefazodone, and etoperidone: clinical and forensic aspects	6
Physiological and pathophysiological roles of hepoxilins and their analogs	6
Correction	6
3D self-assembled nanocarriers for drug delivery	5
Regulation of human UDP-glycosyltransferase (UGT) genes by miRNAs	5
Relationship between blood–brain barrier changes and drug metabolism under high-altitude hypoxia: obstacle or opportunity for drug transport?	5
Pregnane X Receptor (PXR/NR1I2): Linking Drug Metabolism, Bile Acid Detoxification, and Cholesterol Homeostasis	5
Interaction of drugs with gut microbiota modulators	5
The role and current research status of resveratrol in the treatment of osteoarthritis and its mechanisms: a narrative review	4
The multifaceted role of cytochrome P450-Derived arachidonic acid metabolites in diabetes and diabetic cardiomyopathy	4
Ocular drug-metabolizing enzymes: focus on esterases	4
Cutting-edge strategies and critical advancements in characterization and quantification of metabolites concerning translational metabolomics	4
Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms	4
The aminosalicylate - folate connection	3
The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure	3
Effects of cannabidiol and Δ ⁹ -tetrahydrocannabinol on cytochrome P450 enzymes: a systematic review	3
Biotransformation research advances – 2024 year in review	3
Drug transporters in drug disposition – highlights from the year 2023	3
Bioactivation and reactivity research advances – 2021 year in review	3
Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review	3
Enzyme-mediated drug-drug interactions: a review of in vivo and in vitro methodologies, regulatory guidance, and translation to the clinic	3
Pharmacokinetic considerations and strategies for antibody-based therapeutics	3
Effect of inflammation on cytochrome P450-mediated arachidonic acid metabolism and the consequences on cardiac hypertrophy	3
Targeting endothelial cell metabolism in cancerous microenvironment: a new approach for anti-angiogenic therapy	3