OOIR: Observatory of International Research

Papers

(The median citation count of Drug Metabolism Reviews is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Biotransformation research advances – 2022 year in review	41
Transporter-mediated drug-drug interactions: regulatory guidelines, in vitro and in vivo methodologies and translation, special population	33
Introduction to the mini special issue on next generation drug discovery and development: rethinking translational pharmacology for accelerated drug development	32
International Society for the Study of Xenobiotics (ISSX) New Investigator Group Committee 2019–2020 concluding remarks	26
Cutting-edge strategies and critical advancements in characterization and quantification of metabolites concerning translational metabolomics	24
Metabolism of m -CPP, trazodone, nefazodone, and etoperidone: clinical and forensic aspects	23
GSTM1 and GSTT1 polymorphisms in healthy volunteers – a worldwide systematic review	19
Molecular docking to investigate HLA-associated idiosyncratic drug reactions	19
Promising role of peroxisome proliferator-activated receptors in respiratory disorders, a review	19
Insights into pharmacogenetics, drug-gene interactions, and drug-drug-gene interactions	18
Deoxynivalenol and its modified forms: key enzymes, inter-individual and interspecies differences in metabolism	15
The multifaceted role of cytochrome P450-Derived arachidonic acid metabolites in diabetes and diabetic cardiomyopathy	14
Biopolymers as promising vehicles for drug delivery to the brain	13
Biotransformation research advances – 2023 year in review	13
Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms	13
The annoying flaws of gerontological research	13
Metabolic activation of tyrosine kinase inhibitors: recent advance and further clinical practice	12
Pregnane X receptor as a therapeutic target for cholestatic liver injury	11
Ocular drug-metabolizing enzymes: focus on esterases	11
Molecular mechanisms of hepatotoxicity induced by compounds occurring in Evodiae Fructus	10
The role and current research status of resveratrol in the treatment of osteoarthritis and its mechanisms: a narrative review	10
Clinical pharmacokinetics of nebivolol: a systematic review	10
Enzyme-mediated drug-drug interactions: a review of in vivo and in vitro methodologies, regulatory guidance, and translation to the clinic	9
Investigating the association between CYP2J2 inhibitors and QT prolongation: a literature review	9
Scaling factors to inform in vitro - in vivo extrapolation from preclinical and livestock animals: state of the field and recommendations	8

A transcriptional regulatory network of HNF4α and HNF1α involved in human diseases and drug metabolism	8
Pharmacokinetics, toxicological and clinical aspects of ulipristal acetate: insights into the mechanisms implicated in the hepatic toxicity	8
The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure	7
Transporter-mediated drug–drug interactions: advancement in models, analytical tools, and regulatory perspective	7
Herb-drug interaction potential of Astragali Radix : a metabolic perspective	6
Drug metabolism and transport mediated the hepatotoxicity of Pleuropterus multiflorus root: a review	6
Bioactivation and reactivity research advances – 2022 year in review‡	5
Cell-Biomaterial constructs for wound healing and skin regeneration	5
The aminosalicylate - folate connection	5
Drug transporters in drug disposition – highlights from the year 2023	4
Pharmacogenomics in the era of next generation sequencing – from byte to bedside	4
3D self-assembled nanocarriers for drug delivery	4
Novel insights in drug transporter sciences: the year 2021 in review	4
Physiological and pathophysiological roles of hepoxilins and their analogs	4
Melatonin in cancer biology: pathways, derivatives, and the promise of targeted delivery	4
Drug transporters in drug disposition – the year 2022 in review	4
Recent advances in drug transporter sciences: highlights from the year 2020	4
Effect of inflammation on cytochrome P450-mediated arachidonic acid metabolism and the consequences on cardiac hypertrophy	4
Metabolism and detection of designer benzodiazepines: a systematic review	3
Effects of cannabidiol and Δ ⁹ -tetrahydrocannabinol on cytochrome P450 enzymes: a systematic review	3
Targeting endothelial cell metabolism in cancerous microenvironment: a new approach for anti-angiogenic therapy	3
Prediction of drug-induced kidney injury in drug discovery	3
Bioanalytical strategies in drug discovery and development	3
Recent developments inin vitroandin vivomodels for improved translation of preclinical pharmacokinetics and pharmacodynamics data	3
Bioactivation and reactivity research advances – 2023 year in review	3
Novel advances in biotransformation and bioactivation research – 2020 year in review	3
New strategy for rational use of antihypertensive drugs in clinical practice in high-altitude hypoxic environments	3