OOIR: Observatory of International Research

Papers

(The median citation count of Drug Metabolism Reviews is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
The annoying flaws of gerontological research	38
Drug transporters in drug disposition – the year 2022 in review	30
Cell-Biomaterial constructs for wound healing and skin regeneration	29
Enantioselectivity in some physiological and pathophysiological roles of hydroxyeicosatetraenoic acids	28
Differential modulation of cytochrome P450 enzymes by arsenicals in non-human experimental models	20
An in-depth review of PPARγ modulators as anti-diabetes therapeutics	19
New strategy for rational use of antihypertensive drugs in clinical practice in high-altitude hypoxic environments	19
Mechanisms of intestinal pharmacokinetic natural product-drug interactions	18
Cytochrome P450-mediated carbon-carbon bond formation in drug metabolism	18
Assessing and mitigating pH-mediated DDI risks in drug development – formulation approaches and clinical considerations	15
Genetic determinants of paclitaxel-induced peripheral neuropathy: a review of current literature	13
Biopolymers as promising vehicles for drug delivery to the brain	13
Clinical pharmacokinetics of nebivolol: a systematic review	12
Transporter-mediated drug-drug interactions: regulatory guidelines, in vitro and in vivo methodologies and translation, special population	12
Scaling factors to inform in vitro - in vivo extrapolation from preclinical and livestock animals: state of the field and recommendations	12
Metabolic activation of tyrosine kinase inhibitors: recent advance and further clinical practice	12
Favipiravir, remdesivir, and lopinavir: metabolites, degradation products and their analytical methods	11
A transcriptional regulatory network of HNF4α and HNF1α involved in human diseases and drug metabolism	11
In silico ADME and target prediction studies of Alogliptin as drug molecule	9
Effects of intestinal flora on pharmacokinetics and pharmacodynamics of drugs	8
Advances in drug resistance of osteosarcoma caused by pregnane X receptor	8
Impact of DNA methylation on ADME gene expression, drug disposition, and efficacy	8
Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development	8
In-depth understanding of the structure-based reactive metabolite formation of organic functional groups	7
Biotransformation research advances – 2023 year in review	6

The relationship between UGT1A1 gene & various diseases and prevention strategies	6
Metabolism of m -CPP, trazodone, nefazodone, and etoperidone: clinical and forensic aspects	6
Correction	6
Physiological and pathophysiological roles of hepoxilins and their analogs	5
Relationship between blood–brain barrier changes and drug metabolism under high-altitude hypoxia: obstacle or opportunity for drug transport?	5
Melatonin in cancer biology: pathways, derivatives, and the promise of targeted delivery	5
3D self-assembled nanocarriers for drug delivery	5
The multifaceted role of cytochrome P450-Derived arachidonic acid metabolites in diabetes and diabetic cardiomyopathy	4
Regulation of human UDP-glycosyltransferase (UGT) genes by miRNAs	4
The role and current research status of resveratrol in the treatment of osteoarthritis and its mechanisms: a narrative review	4
Cutting-edge strategies and critical advancements in characterization and quantification of metabolites concerning translational metabolomics	4
Interaction of drugs with gut microbiota modulators	4
Ocular drug-metabolizing enzymes: focus on esterases	4
Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms	4
Enzyme-mediated drug-drug interactions: a review of in vivo and in vitro methodologies, regulatory guidance, and translation to the clinic	3
Bioactivation and reactivity research advances – 2021 year in review	3
The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure	3
Drug transporters in drug disposition – highlights from the year 2023	3
The aminosalicylate - folate connection	3