OOIR: Observatory of International Research

Papers

(The TQCC of Drug Metabolism Reviews is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Drug transporters in drug disposition – the year 2022 in review	53
CYP24A1: the pivotal regulator of vitamin D homeostasis, pathophysiology in metabolic and genetic disease, and emerging target for precision medicine	43
Differential modulation of cytochrome P450 enzymes by arsenicals in non-human experimental models	41
Phase II metabolism in xenobiotic biotransformation: general mechanisms and the underestimated role of microbial systems	35
Enantioselectivity in some physiological and pathophysiological roles of hydroxyeicosatetraenoic acids	22
New strategy for rational use of antihypertensive drugs in clinical practice in high-altitude hypoxic environments	22
An in-depth review of PPARγ modulators as anti-diabetes therapeutics	20
Mechanisms of intestinal pharmacokinetic natural product-drug interactions	18
A critical review of analytical tools for the detection of spironolactone and its metabolites	17
Cytochrome P450-mediated carbon-carbon bond formation in drug metabolism	16
Multimolecular interactions from Chinese medicines activate nuclear receptor conformational changes: a potential strategy for anti-inflammatory therapy	15
Assessing and mitigating pH-mediated DDI risks in drug development – formulation approaches and clinical considerations	15
Redox enzyme networks shaping cancer drug metabolism and therapeutic resistance	14
Biopolymers as promising vehicles for drug delivery to the brain	13
Drug transporters in drug disposition – highlights from the year 2024	12
Scaling factors to inform in vitro - in vivo extrapolation from preclinical and livestock animals: state o	11
Genetic determinants of paclitaxel-induced peripheral neuropathy: a review of current literature	11
Clinical pharmacokinetics of nebivolol: a systematic review	11
Transporter-mediated drug-drug interactions: regulatory guidelines, in vitro and in vivo methodologies and translation, special population	11
Metabolism of new drug modalities research advances – 2024 year in review	11
Metabolic activation of tyrosine kinase inhibitors: recent advance and further clinical practice	10
Molecular insights into doxorubicin-induced cardiotoxicity and phytochemical-based cardioprotection: challenges and future strategies	10
A transcriptional regulatory network of HNF4α and HNF1α involved in human diseases and drug metabolism	10
Favipiravir, remdesivir, and lopinavir: metabolites, degradation products and their analytical methods	9