OOIR: Observatory of International Research

Papers

(The H4-Index of Annual Review of Pharmacology and Toxicology is 33. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
How Biologics Have Changed the Drug Discovery Landscape	118
Pharmacology of Intestinal Inflammation and Repair	112
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	106
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	98
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays	90
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology	78
Evolving Approaches for Pharmacological Therapy of Obesity	70
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	66
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”	65
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	64
E-Cigarette Toxicology	63
Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development	62
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”	58
	57
The Gut Microbiome, Metformin, and Aging	55
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer	54
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases	51
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss	51
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges	50
Endocannabinoid-Based Therapies	50
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery	47
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders	47
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	46
Health Digital Twins in Life Science and Health Care Innovation	46
Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon	45

Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	42
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	41
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	40
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	39
Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments	37
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy	36
Translational In Vivo Assays in Behavioral Biology	33
Pharmacogenetics of Antiplatelet Therapy	33