OOIR: Observatory of International Research

Papers

(The median citation count of Annual Review of Pharmacology and Toxicology is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
How Biologics Have Changed the Drug Discovery Landscape	174
Introduction to the Theme “New Approaches, Technology, and Techniques That Advance Pharmacology and Toxicology”	149
Pharmacology of Intestinal Inflammation and Repair	148
The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases	120
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	116
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	89
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	84
Evolving Approaches for Pharmacological Therapy of Obesity	84
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”	83
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	82
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”	82
Community Aspects of HIV Biomedical Prevention	79
Incretin Signaling Neighborhoods and Adverse Drug Reactions	75
Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe	73
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases	70
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss	70
Gβγ Signaling: Lessons Across the Cellular Multiverse	69
Microplastics and Atherosclerosis: Mechanisms	60
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery	58
Health Digital Twins in Life Science and Health Care Innovation	57
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders	53
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	52
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	46
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	45
RNA Splicing as a Therapeutic Target in Cancer	44

Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	44
Pharmacogenetics of Antiplatelet Therapy	43
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy	43
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	42
Translational In Vivo Assays in Behavioral Biology	41
A Mechanistic Framework for Repurposing FDA-Approved Drugs to Combat Antimicrobial Resistance: The Case of Staphylococcus aureus	40
Prospects for Disease Slowing in Parkinson Disease	39
G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications	35
What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants	33
Early Detection of Wellness-to-Disease Transitions in the AI Era: Implications for Pharmacology and Toxicology	32
Targeting Efferocytosis in Inflammaging	31
Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation	30
Progress and Challenges in the Field of Snakebite Envenoming Therapeutics	29
Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health	28
Pharmacological Induction of Granulocyte Cell Death as Therapeutic Strategy	27
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?	25
Alcohol Use Disorder Treatment: Problems and Solutions	25
Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies	24
A Common Adverse Outcome Pathway for Metal(loid)s Inducing Nephrotoxicity to Advance Next-Generation Risk Assessment of Chemical Mixtures	24
Harnessing the Power of Electronic Health Records and Genomics for Drug Discovery	23
Treating Sickle Cell Disease: Gene Therapy Approaches	23
Deciphering Drug Targets and Actions with Single-Cell and Spatial Resolution	22
Antiepileptic Drugs as Potential Dementia Prophylactics Following Traumatic Brain Injury	21
From Fundamental Biology to Toxicology by Way of an Accident	20
G Protein–Coupled Receptor Signaling: New Insights Define Cellular Nanodomains	20
	19
From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation	19
Pharma[e]cology: How the Gut Microbiome Contributes to Variations in Drug Response	19
Dengue Fever Vaccines: Progress and Challenges	18
Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation	18
Genetically Enriched Clinical Trials for Precision Development of Noncancer Therapeutics: A Scoping Review	16
Possible Direction of Drug Discovery Based on Single-Molecule Live Imaging	15
Direct K-Ras Inhibitors to Treat Cancers: Progress, New Insights, and Approaches to Treat Resistance	14
LP(a): Structure, Genetics, Associated Cardiovascular Risk, and Emerging Therapeutics	14
Navigating the Computational Landscape for Drug Repurposing	13
	13