OOIR: Observatory of International Research

Papers

(The median citation count of Annual Review of Pharmacology and Toxicology is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Introduction to the Theme “New Approaches, Technology, and Techniques That Advance Pharmacology and Toxicology”	130
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	129
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays	126
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	125
The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases	120
How Biologics Have Changed the Drug Discovery Landscape	114
Pharmacology of Intestinal Inflammation and Repair	98
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	92
Evolving Approaches for Pharmacological Therapy of Obesity	87
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology	77
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”	76
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	74
Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development	70
	67
E-Cigarette Toxicology	67
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”	66
Community Aspects of HIV Biomedical Prevention	63
Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe	63
Incretin Signaling Neighborhoods and Adverse Drug Reactions	63
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer	60
The Gut Microbiome, Metformin, and Aging	60
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss	57
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges	55
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases	55
Endocannabinoid-Based Therapies	55

Gβγ Signaling: Lessons Across the Cellular Multiverse	54
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders	53
Health Digital Twins in Life Science and Health Care Innovation	49
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	49
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery	48
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	47
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	47
RNA Splicing as a Therapeutic Target in Cancer	46
Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon	46
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	45
Pharmacogenetics of Antiplatelet Therapy	45
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy	38
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	38
Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments	35
A Mechanistic Framework for Repurposing FDA-Approved Drugs to Combat Antimicrobial Resistance: The Case of Staphylococcus aureus	34
Translational In Vivo Assays in Behavioral Biology	33
G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications	32
Prospects for Disease Slowing in Parkinson Disease	32
Drug Target Identification in Tissues by Thermal Proteome Profiling	30
What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants	30
Oxidative Stress and Metabolism: A Mechanistic Insight for Glyphosate Toxicology	30
Early Detection of Wellness-to-Disease Transitions in the AI Era: Implications for Pharmacology and Toxicology	29
Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health	28
Progress and Challenges in the Field of Snakebite Envenoming Therapeutics	28
Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation	27
Pharmacological Induction of Granulocyte Cell Death as Therapeutic Strategy	25
Targeting Efferocytosis in Inflammaging	25
Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine	24
Alcohol Use Disorder Treatment: Problems and Solutions	24
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?	24
A Common Adverse Outcome Pathway for Metal(loid)s Inducing Nephrotoxicity to Advance Next-Generation Risk Assessment of Chemical Mixtures	22
Harnessing the Power of Electronic Health Records and Genomics for Drug Discovery	22
Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders	22
Treating Sickle Cell Disease: Gene Therapy Approaches	21
Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies	21
Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases	21
From Fundamental Biology to Toxicology by Way of an Accident	20
Pharma[e]cology: How the Gut Microbiome Contributes to Variations in Drug Response	19
Deciphering Drug Targets and Actions with Single-Cell and Spatial Resolution	18
Antiepileptic Drugs as Potential Dementia Prophylactics Following Traumatic Brain Injury	18
G Protein–Coupled Receptor Signaling: New Insights Define Cellular Nanodomains	17
Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation	17
From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation	17
Dengue Fever Vaccines: Progress and Challenges	16
Possible Direction of Drug Discovery Based on Single-Molecule Live Imaging	14
Precision Medicine Approaches for Infantile-Onset Developmental and Epileptic Encephalopathies	14
Genetically Enriched Clinical Trials for Precision Development of Noncancer Therapeutics: A Scoping Review	14
Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure	14
Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor	13
LP(a): Structure, Genetics, Associated Cardiovascular Risk, and Emerging Therapeutics	13

Direct K-Ras Inhibitors to Treat Cancers: Progress, New Insights, and Approaches to Treat Resistance	13
Endocrine-Disrupting Chemicals and Child Health	13