OOIR: Observatory of International Research

Papers

(The median citation count of Annual Review of Pharmacology and Toxicology is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
How Biologics Have Changed the Drug Discovery Landscape	122
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	119
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays	112
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	104
Pharmacology of Intestinal Inflammation and Repair	96
Evolving Approaches for Pharmacological Therapy of Obesity	93
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	85
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology	75
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”	74
Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development	69
E-Cigarette Toxicology	67
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	66
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”	61
	60
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer	60
The Gut Microbiome, Metformin, and Aging	57
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges	56
Community Aspects of HIV Biomedical Prevention	56
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss	55
Endocannabinoid-Based Therapies	52
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders	51
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases	51
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	49
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery	49
Health Digital Twins in Life Science and Health Care Innovation	48

Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	46
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	46
Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon	44
RNA Splicing as a Therapeutic Target in Cancer	41
Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments	40
Pharmacogenetics of Antiplatelet Therapy	40
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	40
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	38
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy	37
Translational In Vivo Assays in Behavioral Biology	37
Drug Target Identification in Tissues by Thermal Proteome Profiling	34
Prospects for Disease Slowing in Parkinson Disease	34
Oxidative Stress and Metabolism: A Mechanistic Insight for Glyphosate Toxicology	33
What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants	31
G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications	31
Targeting Efferocytosis in Inflammaging	29
Progress and Challenges in the Field of Snakebite Envenoming Therapeutics	29
Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation	28
Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders	27
Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health	27
Pharmacological Induction of Granulocyte Cell Death as Therapeutic Strategy	27
Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine	25
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?	23
Alcohol Use Disorder Treatment: Problems and Solutions	22
Treating Sickle Cell Disease: Gene Therapy Approaches	21
Harnessing the Power of Electronic Health Records and Genomics for Drug Discovery	21
Pharma[e]cology: How the Gut Microbiome Contributes to Variations in Drug Response	20
Antiepileptic Drugs as Potential Dementia Prophylactics Following Traumatic Brain Injury	20
Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies	20
Deciphering Drug Targets and Actions with Single-Cell and Spatial Resolution	20
Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases	20
From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation	19
Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation	18
Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure	18
G Protein–Coupled Receptor Signaling: New Insights Define Cellular Nanodomains	18
Precision Medicine Approaches for Infantile-Onset Developmental and Epileptic Encephalopathies	17
Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor	16
Genetically Enriched Clinical Trials for Precision Development of Noncancer Therapeutics: A Scoping Review	16
Direct K-Ras Inhibitors to Treat Cancers: Progress, New Insights, and Approaches to Treat Resistance	15
LP(a): Structure, Genetics, Associated Cardiovascular Risk, and Emerging Therapeutics	15