OOIR: Observatory of International Research

Papers

(The median citation count of Annual Review of Pharmacology and Toxicology is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Introduction to the Theme “New Approaches, Technology, and Techniques That Advance Pharmacology and Toxicology”	195
Pharmacology of Intestinal Inflammation and Repair	165
How Biologics Have Changed the Drug Discovery Landscape	161
The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases	141
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	125
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	100
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	98
Evolving Approaches for Pharmacological Therapy of Obesity	93
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”	92
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	91
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”	90
Incretin Signaling Neighborhoods and Adverse Drug Reactions	89
Community Aspects of HIV Biomedical Prevention	87
Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe	86
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases	82
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss	82
Gβγ Signaling: Lessons Across the Cellular Multiverse	79
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders	67
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery	66
Microplastics and Atherosclerosis: Mechanisms	65
Therapeutics for Alcohol-Associated Liver Disease	60
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	59
Health Digital Twins in Life Science and Health Care Innovation	57
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	56
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	54

RNA Splicing as a Therapeutic Target in Cancer	51
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	47
Pharmacogenetics of Antiplatelet Therapy	47
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	47
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy	46
Translational In Vivo Assays in Behavioral Biology	44
A Mechanistic Framework for Repurposing FDA-Approved Drugs to Combat Antimicrobial Resistance: The Case of Staphylococcus aureus	43
Prospects for Disease Slowing in Parkinson Disease	40
G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications	36
What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants	35
Early Detection of Wellness-to-Disease Transitions in the AI Era: Implications for Pharmacology and Toxicology	35
Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health	33
Targeting Efferocytosis in Inflammaging	33
Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation	31
Progress and Challenges in the Field of Snakebite Envenoming Therapeutics	30
Pharmacological Induction of Granulocyte Cell Death as Therapeutic Strategy	29
Harnessing the Power of Electronic Health Records and Genomics for Drug Discovery	28
Alcohol Use Disorder Treatment: Problems and Solutions	28
Treating Sickle Cell Disease: Gene Therapy Approaches	28
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?	28
Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies	26
From Fundamental Biology to Toxicology by Way of an Accident	26
A Common Adverse Outcome Pathway for Metal(loid)s Inducing Nephrotoxicity to Advance Next-Generation Risk Assessment of Chemical Mixtures	26
	25
Antiepileptic Drugs as Potential Dementia Prophylactics Following Traumatic Brain Injury	24
G Protein–Coupled Receptor Signaling: New Insights Define Cellular Nanodomains	23
Deciphering Drug Targets and Actions with Single-Cell and Spatial Resolution	23
From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation	21
Pharma[e]cology: How the Gut Microbiome Contributes to Variations in Drug Response	21
Dengue Fever Vaccines: Progress and Challenges	20
Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation	20
Direct K-Ras Inhibitors to Treat Cancers: Progress, New Insights, and Approaches to Treat Resistance	19
Genetically Enriched Clinical Trials for Precision Development of Noncancer Therapeutics: A Scoping Review	19
	18
LP(a): Structure, Genetics, Associated Cardiovascular Risk, and Emerging Therapeutics	18
Possible Direction of Drug Discovery Based on Single-Molecule Live Imaging	18
Navigating the Computational Landscape for Drug Repurposing	17
CaMKII as a Therapeutic Target in Cardiovascular Disease	16