OOIR: Observatory of International Research

Papers

(The median citation count of Annual Review of Pharmacology and Toxicology is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Pharmacology of Intestinal Inflammation and Repair	125
How Biologics Have Changed the Drug Discovery Landscape	124
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays	117
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	112
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	104
Evolving Approaches for Pharmacological Therapy of Obesity	95
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	94
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology	79
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”	78
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	71
E-Cigarette Toxicology	69
Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development	69
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”	65
	63
Community Aspects of HIV Biomedical Prevention	62
The Gut Microbiome, Metformin, and Aging	60
Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe	58
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer	57
Endocannabinoid-Based Therapies	56
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss	55
Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges	52
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery	51
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases	51
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	50
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders	48

Gβγ Signaling: Lessons Across the Cellular Multiverse	48
Health Digital Twins in Life Science and Health Care Innovation	47
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	45
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	45
Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon	42
RNA Splicing as a Therapeutic Target in Cancer	42
Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments	41
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	41
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	41
Pharmacogenetics of Antiplatelet Therapy	40
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy	35
Translational In Vivo Assays in Behavioral Biology	34
Prospects for Disease Slowing in Parkinson Disease	34
Drug Target Identification in Tissues by Thermal Proteome Profiling	32
G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications	32
What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants	30
Oxidative Stress and Metabolism: A Mechanistic Insight for Glyphosate Toxicology	30
Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation	30
Progress and Challenges in the Field of Snakebite Envenoming Therapeutics	27
Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health	27
Targeting Efferocytosis in Inflammaging	27
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?	25
Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders	25
Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine	24
Pharmacological Induction of Granulocyte Cell Death as Therapeutic Strategy	23
Alcohol Use Disorder Treatment: Problems and Solutions	23
A Common Adverse Outcome Pathway for Metal(loid)s Inducing Nephrotoxicity to Advance Next-Generation Risk Assessment of Chemical Mixtures	22
Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases	21
Harnessing the Power of Electronic Health Records and Genomics for Drug Discovery	21
Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies	21
Deciphering Drug Targets and Actions with Single-Cell and Spatial Resolution	21
Treating Sickle Cell Disease: Gene Therapy Approaches	21
Antiepileptic Drugs as Potential Dementia Prophylactics Following Traumatic Brain Injury	20
G Protein–Coupled Receptor Signaling: New Insights Define Cellular Nanodomains	19
From Fundamental Biology to Toxicology by Way of an Accident	18
Pharma[e]cology: How the Gut Microbiome Contributes to Variations in Drug Response	18
From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation	17
Dengue Fever Vaccines: Progress and Challenges	16
Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation	16
Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure	16
Genetically Enriched Clinical Trials for Precision Development of Noncancer Therapeutics: A Scoping Review	15
Aryl Hydrocarbon Receptor and Its Diverse Ligands and Functions: An Exposome Receptor	15
Precision Medicine Approaches for Infantile-Onset Developmental and Epileptic Encephalopathies	15
LP(a): Structure, Genetics, Associated Cardiovascular Risk, and Emerging Therapeutics	15