OOIR: Observatory of International Research

Papers

(The median citation count of Annual Review of Pharmacology and Toxicology is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Introduction to the Theme “New Approaches, Technology, and Techniques That Advance Pharmacology and Toxicology”	178
The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases	154
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	151
Pharmacology of Intestinal Inflammation and Repair	128
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	118
How Biologics Have Changed the Drug Discovery Landscape	92
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	89
Evolving Approaches for Pharmacological Therapy of Obesity	85
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”	85
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	85
Community Aspects of HIV Biomedical Prevention	83
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”	79
Incretin Signaling Neighborhoods and Adverse Drug Reactions	76
Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe	75
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases	75
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss	73
Gβγ Signaling: Lessons Across the Cellular Multiverse	72
Health Digital Twins in Life Science and Health Care Innovation	61
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders	59
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	58
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery	54
Microplastics and Atherosclerosis: Mechanisms	54
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	49
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	48
RNA Splicing as a Therapeutic Target in Cancer	47

Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	46
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy	44
Pharmacogenetics of Antiplatelet Therapy	44
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	43
A Mechanistic Framework for Repurposing FDA-Approved Drugs to Combat Antimicrobial Resistance: The Case of Staphylococcus aureus	42
Prospects for Disease Slowing in Parkinson Disease	41
Translational In Vivo Assays in Behavioral Biology	40
G Protein–Coupled Estrogen Receptor GPER: Molecular Pharmacology and Therapeutic Applications	36
Early Detection of Wellness-to-Disease Transitions in the AI Era: Implications for Pharmacology and Toxicology	34
Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation	32
What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants	32
Progress and Challenges in the Field of Snakebite Envenoming Therapeutics	30
Targeting Efferocytosis in Inflammaging	29
Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health	29
Pharmacological Induction of Granulocyte Cell Death as Therapeutic Strategy	28
Alcohol Use Disorder Treatment: Problems and Solutions	27
Treating Sickle Cell Disease: Gene Therapy Approaches	25
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?	25
A Common Adverse Outcome Pathway for Metal(loid)s Inducing Nephrotoxicity to Advance Next-Generation Risk Assessment of Chemical Mixtures	24
Harnessing the Power of Electronic Health Records and Genomics for Drug Discovery	24
From Fundamental Biology to Toxicology by Way of an Accident	24
Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies	24
	24
Deciphering Drug Targets and Actions with Single-Cell and Spatial Resolution	21
Antiepileptic Drugs as Potential Dementia Prophylactics Following Traumatic Brain Injury	21
G Protein–Coupled Receptor Signaling: New Insights Define Cellular Nanodomains	20
Pharma[e]cology: How the Gut Microbiome Contributes to Variations in Drug Response	20
Dengue Fever Vaccines: Progress and Challenges	19
Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation	19
From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation	19
Genetically Enriched Clinical Trials for Precision Development of Noncancer Therapeutics: A Scoping Review	17
Direct K-Ras Inhibitors to Treat Cancers: Progress, New Insights, and Approaches to Treat Resistance	16
Possible Direction of Drug Discovery Based on Single-Molecule Live Imaging	16
	15
LP(a): Structure, Genetics, Associated Cardiovascular Risk, and Emerging Therapeutics	15
Navigating the Computational Landscape for Drug Repurposing	14