OOIR: Observatory of International Research

Papers

(The TQCC of Annual Review of Pharmacology and Toxicology is 41. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Introduction to the Theme “New Approaches, Technology, and Techniques That Advance Pharmacology and Toxicology”	178
The Promises and Prospects of Long-Acting Therapeutics for Treatment and Prevention of Infectious Diseases	154
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	151
Pharmacology of Intestinal Inflammation and Repair	128
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	118
How Biologics Have Changed the Drug Discovery Landscape	92
Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities	89
Introduction to the Theme “Pharmacological Individuality: New Insights and Strategies for Personalized and Precise Drug Treatment”	85
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?	85
Evolving Approaches for Pharmacological Therapy of Obesity	85
Community Aspects of HIV Biomedical Prevention	83
Introduction to the Theme “Development of New Drugs: Moving from the Bench to Bedside and Improved Patient Care”	79
Incretin Signaling Neighborhoods and Adverse Drug Reactions	76
Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases	75
Multisystem Toxicity of E-Cigarettes in Preclinical and Clinical Studies: Pathophysiologic Effects of E-Cigarette Aerosol Exposures from Head to Toe	75
Hear and Now: Ongoing Clinical Trials to Prevent Drug-Induced Hearing Loss	73
Gβγ Signaling: Lessons Across the Cellular Multiverse	72
Health Digital Twins in Life Science and Health Care Innovation	61
G Protein–Coupled Receptor Heteromers in Brain: Functional and Therapeutic Importance in Neuropsychiatric Disorders	59
OAT, OATP, and MRP Drug Transporters and the Remote Sensing and Signaling Theory	58
GPCR Biosensors to Study Conformational Dynamics and Signaling in Drug Discovery	54
Microplastics and Atherosclerosis: Mechanisms	54
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	49
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	48
RNA Splicing as a Therapeutic Target in Cancer	47

Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	46
Pharmacogenetics of Antiplatelet Therapy	44
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy	44
Cognitive Impairment Associated with Schizophrenia: From Pathophysiology to Treatment	43
A Mechanistic Framework for Repurposing FDA-Approved Drugs to Combat Antimicrobial Resistance: The Case of Staphylococcus aureus	42
Prospects for Disease Slowing in Parkinson Disease	41