OOIR: Observatory of International Research

Papers

(The TQCC of Annual Review of Pharmacology and Toxicology is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Synthetic Cannabinoids: A Pharmacological and Toxicological Overview	115
Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon	108
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?	98
Fibroblast Growth Factor–Based Pharmacotherapies for the Treatment of Obesity-Related Metabolic Complications	87
Pharmacological Induction of Granulocyte Cell Death as Therapeutic Strategy	86
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets	65
Understanding the Chemical Exposome During Fetal Development and Early Childhood: A Review	62
Pharmacology of Intestinal Inflammation and Repair	61
Toluene Toxicity in the Brain: From Cellular Targets to Molecular Mechanisms	61
Pollution of Soil by Pharmaceuticals: Implications for Metazoan and Environmental Health	58
Targeting G Protein–Coupled Receptors in Immuno-Oncological Therapies	56
How Biologics Have Changed the Drug Discovery Landscape	53
Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders	51
Alcohol Use Disorder Treatment: Problems and Solutions	50
Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays	50
The Nocebo Effect	49
Thioredoxin Reductase Inhibition for Cancer Therapy	49
CaMKII as a Therapeutic Target in Cardiovascular Disease	45
Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease	44
Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine	44
Endocrine-Disrupting Chemicals and Child Health	43
Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease	43
Apathy and Motivation: Biological Basis and Drug Treatment	42
Systems Biology of the Vasopressin V2 Receptor: New Tools for Discovery of Molecular Actions of a GPCR	39
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology	38

Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases	37
Treating Sickle Cell Disease: Gene Therapy Approaches	36
Decoding the Therapeutic Target SVEP1: Harnessing Molecular Trait GWASs to Unravel Mechanisms of Human Disease	35
Pharmacogenetic Panel Testing: A Review of Current Practice and Potential for Clinical Implementation	34
Phosphodiesterases: Evolving Concepts and Implications for Human Therapeutics	28
Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies	28
Evolving Approaches for Pharmacological Therapy of Obesity	26