OOIR: Observatory of International Research

Papers

(The TQCC of Hemoglobin is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
A Novel 5 kb Deletion in theβ-Globin Gene Cluster Identified in a Chinese Patient	24
Noninvasive Prenatal Diagnosis of SEA-Thalassemia by Combining 1000 Genomes Database and Relative Haplotype Dosage	16
Clinical Exome Sequencing Reveals Novel Mutations in SPTB Gene Associated with Hereditary Spherocytosis in Patients with Suspected Congenital Hemolytic Anemia	13
Coexisting β-Thalassemia Trait, Gilbert Syndrome and Alpha-Globin Gene Triplication in a Child with Non-Transfusion Dependent Thalassemia Phenotype	12
Long Non-Coding RNA H19 Leads to Upregulation of γ-Globin Gene Expression during Erythroid Differentiation	12
A New Case of Hb Headington (HBB: c.217A>C) Due to a New DNA Transversion, Found in a Patient with Type 2 Diabetes Mellitus	11
Splice Acceptor Mutation [ HBB :c.93-2A > T] in a Patient with Hb S/β ⁰ -Thalassemia	11
The First Iranian Case of Unstable Hemoglobin Santa Ana	11
Strong Positive Dichlorophenolindophenol Precipitation Suggests Hb Dhonburi (or Hb Neapolis) (HBB: c.380T>G) Inheritance in a Couple at Risk for Severe β-Thalassemia	10
Morbidity and Mortality Associated with COVID-19 and Acute Chest Syndrome in Sickle Cell Disease Patients	9
A novel α Globin Gene Cluster Duplication, αααα³⁸⁰ Heterozygous β⁰-Thal Variant, Leading to a Blood Transfusion-Dependent Phenotype	8
ATG-Thymoglobulin Versus ATG-Fresenius for Conditioning in Thalassemia Patients Who Underwent Allogenic Stem Cell Transplantation from Matched-Sibling Donor: A Tertiary Cancer Care Center Short-Term E	8
Effect of Hydroxyurea Therapy on Growth Parameters in Older Children (6-15 Year-Old) with Sickle Cell Disease: Low Dose Versus High Dose	8
Hb Jishui [HBA1: c.225C>G, Codon 74 (GAC>GAG), Asp→Glu]: A Novel α Chain Hemoglobin Variant Detected During Hb A_1c Measurement	7
Submitting Novel Globin Gene Variants to Hemoglobin	7
Research Progress of Cell-Free Fetal DNA in Non-Invasive Prenatal Diagnosis of Thalassemia	6
High Systolic Blood Pressure, Anterior Segment Changes and Visual Impairment Independently Predict Sickle Cell Retinopathy	6
A Triple-Heterozygous β-Thalassemia Patient Demonstrated an Unusual Electrophoresis Pattern Due to a Novel β⁰ Mutation [an IVS-II-654 (C>T) mutation with a Hb Zürich-Langstrasse (HBB<	6
Gene Therapies for Hemoglobinopathies: Promises and Challenges	5
Molecular Identification and the Hematological Findings of Four Novel Variants in Globin Genes in Jiangxi Province of Southern China	5
A Review of Gene Therapies for Hemoglobinopathies	5
Identification of a β-Globin Gene Mutation with the Genotype β-28(A > G), IVS-I-5(G > A)/βCD 71/72(+A) Using Third-Generation Sequencing	5
Strengthening Health System and Community Mobilization for Sickle Cell Disease Screening and Management among Tribal Populations in India: An Interventional Study	4
Evaluation of the Function of a Rare Variant in the 3'-Untranslated Region of the β-Globin Gene	4
Dominantly Inherited β-Thalassemia Caused by a Single Nucleotide Deletion in Exon 3 of the β-Globin Gene: Hb Xiangyang (HBB: c.393delT)	4

Hb Calgary (HBB: c.194G>T): A Highly Unstable Hemoglobin Variant with a β-Thalassemia Major Phenotype	4
A 6-Year Follow-up of a Chinese Child with Homozygous β ⁰ -Thalaasemia and a Heterozygous KLF1 Mutation	4
The Spectrum of HBB Mutations among 2315 Beta Thalassemia Patients of a Reference Clinic in Tehran-Iran	3
Rapid Identification of β-Thalassemia, Hb E, and High Hb F Determinants Using a High-Resolution Melting Analysis: Application in Prenatal Diagnosis in Southern Thailand	3
Thalassemia in Malaysia	3
The Most Common Types of 3.7 Kilobase Deletion in the Iranian Population	3
A New δ-Globin Gene Variant: Hb A2-Yulin [δ46(CD5)Gly→Arg, HBD : C.139G > A]	3
Fist Detection of Hb Suqian[β42(CD1) Phe→Leu, HBB:c.129T > A] in Han Chinese	3
A Rare Case of Abnormal Hemoglobin Variant Hb Mizuho: [HBB: c.206T > C β 68(E12) Leu-Pro]: A First Report in the Chinese Population	3
Hb Huadu [α124(H7)Ser→Thr (TCC>ACC), HBA2: c.373T>A]: A Novel Variant of the α-Globin Gene	3
Adherence to Iron Chelation Therapy Among Children with Beta Thalassemia Major: A Multicenter Cross-Sectional Study	3
Dynamic Viscosity of Hemoglobin Solutions Determined by Transverse Proton Magnetic Relaxation	3
First Report of Hb Youngstown in Capillary Electrophoresis and Overlapping Hb Analysis Findings with Hb Rush	3
Prediction of Heart and Liver Iron Overload in β-Thalassemia Major Patients Using Machine Learning Methods	3
Acute Chest Syndrome in Sickle Cell Disease: Clinical Presentation and Outcomes. The Experience of a Single Thalassemia and Sickle Cell Unit in a University Hospital	3
Hypercoagulability in Sickle Cell Disease: A Thrombo-Inflammatory Mechanism	3
Point-of-Care Newborn Screening for Sickle Cell Disease at Selected Health Facilities in the Gambia	3
Polyneuropathy Associated with Age of Starting the Transfusion and Serum Ferritin Level in Iranian Patients with Thalassemia Major and Intermedia	3
Current Status of β-Thalassemic Burden in India	3
Severe Hb H Disease Caused by Hb Zürich–Albisrieden (HBA1: c.178G>C): Another Case Report	2
A Novel 165 Kb Duplication Involving the α-Globin Gene Cluster Is Identified by Low-Pass Whole Genome Sequencing in a Chinese Thalassemia Intermedia Patient	2
Haplotype-Specific Genetic Epidemiology of Sickle Cell Anemia Patients in Accra, Ghana: Patterns, Clinical Implications, and Public Health Responses	2
The Effect of HBB: c.-121C>T Variant [–71 (C>T)] on the β-Globin Promoter: Case Series Study	2
Silent Cerebral Infarcts in Iraqi Patients with Sickle Cell Disease	2
Effect of deletions in the α-globin gene on the phenotype severity of β-thalassemia	2
Premarital Screening is Pivotal in Reducing the Births of Babies Affected with Thalassemia Major in Iraq	2
A Case of Fat Embolism Syndrome with Cerebral Involvement in Sickle Cell Anemia	2
Hb Wanjiang: A New β-Globin Chain Variant with Two Amino Acid Substitutions (HBB: c.255_264delinsTTTTTCTCAG)	2
Prevalence and Spectrum of β-Thalassemia Mutations in Baghdad, Iraq: Data from the Premarital Screening Program	2
A Novel Frameshift Mutation( HBA2 :C.337delC) Associated With α-Thalassemia Trait Detected by Next-Generation Sequencing in Southern China	2
Ameliorating Mental Health Issues in Sickle Cell Disease Patients: A Viewpoint	2
Hb Laibin [β96(FG3)Leu→Arg; HBB: c.290T>G]: A Novel Hemoglobin Variant Described in a Chinese Family	2
Identification of a Novel Variant c.163delG in HBB Gene Resulting in a Beta Null Phenotype in a Proband with Thalassemia Intermedia	2
Hb Nivaria: A New Hemoglobin Variant with a Shortened α-Globin Chain [α139(HC1)Lys→Stop; HBA1: c.418A>T]	2
A New Hemoglobin Variant, Hb Natal (HBA1: c.423C>A), Found in a Greek Family	2
High Prevalence of Hb Riccarton Challenges HbA1c Analysis in a Danish Clinical Laboratory Using the Tosoh G11	2
The Long-Term Efficacy of Deferiprone in Thalassemia Patients With Iron Overload: Real-World Data from the Registry Database	2
Hereditary Hemolytic Anemia Due to PIEZO1 Red Blood Cell Membrane Defect	2
Spectrum of β-Thalassemia Mutations in Some Areas of Guangxi Zhuang Autonomous Region of Southern China: A Study on a Pediatric Population Aged 0–15 Years	2
Bringing Sickle Cell Disease Care Closer to Home: Feasibility and Efficacy of a Quality Improvement Initiative at a Community Hospital	2
Levels of Serum Ferritin and Hepcidin in Patients with Uncomplicated Falciparum Malaria in Hodeidah, Yemen: Considerations for Assessing Iron Status	2
Dominant β-Thalassemia Phenotype Caused by Hb Dieppe (HBB: c.383A>G): Another Case Report	2
Hb Ryazan: An Elongated C‐Terminal β-Chain Due to a New Frameshift Mutation, HBB: c.396delG p.Val133Trpfs*25	2
Alpha Thalassemia Major: From a Lethal to a Treatable Condition	2
Identification of a Novel Mutation in the 3′ Untranslated Region of the β-Globin Gene (HBB:c.*132C>G) in a Chinese Family	2
Iron Chelators, Such as Deferasirox, When Combined With Hydroxyurea, Provide an Additional Benefit of Iron Chelation in Patients Receiving Chronic Transfusion Therapy	2