American Journal of Physiology-Heart and Circulatory Physiology

Article	Citations
Expanding the supply of donor hearts through donation after circulatory death	77
The multifaceted roles of red blood cells in health and disease	75
Temporal effects of sympathetic denervation on aortic remodeling and rupture in experimental abdominal aortic aneurysm	74
Stem cell-derived heterocellular atrial engineered cardiac tissue with comparisons to native human atrial myocardium	63
Farther and faster: enhancing skeletal muscle performance	60
The vulnerable preterm heart: tale from the two chambers	58
lncRNAs in vascular senescence and microvascular remodeling	52
Editorial Board	51
Parental obesity predisposes male and female offspring to exacerbated cardiac dysfunction and increased mortality after myocardial infarction	50
Modifying the electrical excitability of cardiomyocytes in rainbow trout ( Oncorhynchus mykiss ) through exercise training	49
Volume responsiveness revisited: an observational multicenter study of continuous versus binary outcomes combining echocardiography and venous return physiology	46
Implications of Sm22α-Cre expression in keratinocytes and unanticipated inflammatory skin lesion in a model of atherosclerosis	45
The meaning of volume responsiveness and its relationship to venous return	44
Sex differences in cardiovascular disease and dysregulation in Down syndrome	40
An in silico approach to understanding the interaction between cardiovascular and pulmonary lymphatic dysfunction	39
Mannitol and hyponatremia regulate cardiac ventricular conduction in the context of sodium channel loss of function	38
Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum	37
Immune interactions in pembrolizumab (PD-1 inhibitor) cancer therapy and cardiovascular complications	37
An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency	36
Prenatal stress induces sex- and tissue-specific alterations in insulin pathway of Wistar rats offspring	36
Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure	35
Guidelines for assessing ventricular pressure-volume relationships in rodents	35
Anthracycline cardiotoxicity is exacerbated by global p38β genetic ablation in a sexually dimorphic manner but unaltered by cardiomyocyte-specific p38α loss	35
Sclerostin ablation prevents aortic valve stenosis in mice	33
Adverse pregnancy outcomes and renal-vascular function in the early years after delivery	33

Innervation of adipocytes is limited in mouse perivascular adipose tissue	32
Parental obesity exacerbates cognitive dysfunction and cardiac vulnerability in offspring of an Alzheimer disease model	32
Sex Differences in the Peripheral Determinants of Oxygen Transport and Utilization in Patients with Heart Failure with Preserved Ejection Fraction	32
Closing the window on COVID-19 case-control studies	31
Genetic deletion of cytoglobin exacerbates cardiac hypertrophy and inhibits cardiac fibroblast activation independent of changes in blood pressure	31
Chronotype and metabolic syndrome in midlife: findings from the Northern Finland Birth Cohort 1966	29
Connecting the dots between FXR1 isoforms and miR-1 in pediatric dilated cardiomyopathy	29
Role of membrane microdomains in cardiac protection: strategies for diabetic cardiomyopathy	28
Is a decline in myocardial citrullination in the aged female heart really PAD2 the bone?	28
Sleeping on oxidative stress as a mechanism underlying cardiovascular risk in chronic anxiety	28
Cardiac stasis imaging, stroke, and silent brain infarcts in patients with nonischemic dilated cardiomyopathy	28
X’s, Y’s, and vascular ties: exploring the role of sex chromosomes in arterial stiffness and vascular aging	28
Guidelines for in vivo models of developmental programming of cardiovascular disease risk	28
Inflammation in a severe model of dystrophic cardiomyopathy contains a high proportion of T cells that contribute to onset of pathology	27
Mechanisms matter: a powerful example of insights gained through computational physiology	27
Tissue inhibitor of metalloproteinase-4 deletion in mice impacts maternal cardiac function during pregnancy and postpartum	27
Reflex sympathetic activation to inspiratory muscle loading is attenuated in females relative to males	27
Cardiac health, type I collagen, and aging in the oim/oim mouse model of osteogenesis imperfecta and a cohort of adults with OI	27
Exercise as a Vital Sign in Cardiopulmonary Disease: Insights from Wave Intensity Analysis	27
Reply to Skalidis et al.	27
Electronic hookah (waterpipe) vaping reduces vascular endothelial function: the role of nicotine	27
Modes of onset of ventricular arrhythmias in J-wave syndromes: Mechanistic insights from computational modeling	26
Relative contributions of mitochondrial and nonmitochondrial oxidative stress in age-related cutaneous microvascular endothelial dysfunction	26
Arterial stiffness preceding metabolic syndrome in 3,862 adolescents: a mediation and temporal causal longitudinal birth cohort study	26
Interaction of macro- and microvascular function underlies brachial artery flow-mediated dilation in humans	26
Sexual dimorphism of psychological stress-induced susceptibility to ischemic heart disease: Is the king naked?	25
Fetal cardiac troponin I levels decline toward birth in sheep	25
Assessment of impact of low-flow state on long-term outcome in multiethnic population using cardiac magnetic resonance	24
Correction for Ranjan et al., volume 328, 2025, p. H447–H459	24
Cardiomyocyte-specific disruption of soluble epoxide hydrolase limits inflammation to preserve cardiac function	24
Constipation as a new nontraditional significant contributor to cardiovascular disease	24
Corrigendum for Bigler et al., volume 327, 2024, p. H1124–H1131	24
Impact of ischemia on left atrial remodeling and dysfunction in swine models of mitral regurgitation	24
To err, KIR2 that is, on the side of vasodilation in aging	23
A perinatal approach for unravelling mitochondrial function in preeclampsia and fetal growth restriction: a role for mitochondrial targeted therapies	23
Programming the heart: prenatal glucocorticoids and sex-specific cardiovascular risk	23
Corrigendum for Methawasin et al., volume 328, 2025, p. H719–H733	23
Insights into the associations between the gut microbiome, its metabolites, and heart failure	23
Vascular insulin resistance as a potential mechanism of increased cardiovascular risk in gestational diabetes	22
Coronary artery endothelial function and aging in people with HIV and HIV-negative individuals	22
When it comes to the heart, age, and sex matter (sometimes)	22
Sex differences in the functional morphology of coronary arteries in embryonic mice	22
Differential right ventricular afterload during exercise in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension	21
Beyond TAPSE: clinical and methodological perspectives on 3D-derived right ventricular	21
Accelerating systematic reviews: a novel 1-wk screening protocol using rule-based automation with AI-assisted Python coding	21
Deep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity in RBM20 cardiomyopathy	21
Increased adiposity impairs vascular function in postmenopausal women in hemodialysis	20
Temporal mineralocorticoid receptor activation regulates the molecular clock and transcription of cardiovascular disease modulators in myeloid cells	20
Multiomic and electrophysiologic analyses reveal that an inherited MRC2 variant causes fibroblast dysfunction and increased atrial fibrillation susceptibility	20
Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia	20

Novel role of vascular chemerin in blood vessel tone	20
The role of α 2 -adrenergic mechanisms in sympathetic baroreflex control of human blood pressure	20
Echocardiographic imaging in conscious, unsedated sheep: a novel approach enabling apical views for advanced cardiac assessment	20
Beyond the QT interval: how QT/RR hysteresis may reveal a sex-dependent hidden risk for cardiac arrhythmias	19
Structural and functional adaptations of human cardiomyocytes in metabolic disease and heart failure	19
Sex-specific responses to slow progressive pressure overload in a large animal model of HFpEF	19
Sex as a biological variable in exercise prescription: a critical consideration in developing a road map for sex-related differences in cardiovascular research	19
Are supine assessments an ecologically valid method to characterize sitting-induced declines in lower-limb vascular health?	19
Bedding as a variable affecting fasting blood glucose and vascular physiology in mice	19
Detecting rapid elevations in blood pressure using a novel pulse arrival time and machine learning technique	19
Sugar-coating the endothelium: adaptive or maladaptive?	19
Salsalate negatively impacts microvascular function in women with endometriosis	18
Single-cell ionic current phenotyping explains stem cell-derived cardiomyocyte action potential morphology	18
Rostafuroxin ameliorates cardiac glycoside-induced cardiomyocyte electrolyte imbalances and arrhythmia in ovo	18
Contributions of cardiac output and total peripheral resistance to interindividual variability in peak exercise blood pressure in young adults	18
Bone morphogenetic protein 10: clinical correlates and risk of incident atrial fibrillation	18
Influence of exercise training on the left atrium: implications for atrial fibrillation, heart failure, and stroke	18
Statin therapy improves locomotor muscle microvascular reactivity in patients with heart failure with preserved ejection fraction	18
Corrigendum for Ferreira et al., volume 325, 2023, p. H774–H789	18
Who was the catalyst for the doubling of NIH funding in the late 1990s? Maybe we should thank Senator Tom Daschle	17
Advanced phenotyping in patients with a Fontan circulation uncovers effects of pulmonary vascular disease	17
Aortic aneurysm and dissection: complement and precision medicine in aortic disease	17
Whole genome transcriptomics reveal distinct atrial versus ventricular responses to neonatal hyperoxia	17
Serial and regional assessment of the right ventricular molecular and functional response to pressure loading	17
Predictive value of triglyceride-glucose index for the evaluation of coronary artery disease severity and occurrence of major adverse cardiovascular events	17
Milieu-dependent small-cavity diabetic HFpEF in the DIO-STZ model	17
Early- to mid-gestational testosterone excess leads to adverse cardiac outcomes in postpartum sheep	16
Female mice are protected from impaired parenchymal arteriolar TRPV4 function and impaired cognition in hypertension	16
Procurement and preservation of neonatal porcine cardiac tissue	16
Ventricular-arterial coupling and cardiovascular risk among young adults: The African-PREDICT study	16
Skin pigmentation is negatively associated with circulating vitamin D concentration and cutaneous microvascular endothelial function	16
Cardiovascular and aortic wave reflection responses to evening binge alcohol consumption	16
Real-time visualization of dextran extravasation in intermittent hypoxia mice using noninvasive SWIR imaging	16
Sublingual microcirculatory function as a prognostic indicator of general microvascular health	16
Ebbs and tides of endothelial K+ currents that regulate blood flow	16
Role of adropin in arterial stiffening associated with obesity and type 2 diabetes	16
Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection	16
Impact of ovary-intact menopause in a mouse model of heart failure with preserved ejection fraction	16
Mechanical response of cardiac microtissues to acute localized injury	16
Sex differences in aortic valve inflammation and remodeling in chronic severe aortic regurgitation	16
Acceleration of age-related impairments in vascular function in women: interrogation of the (un)usual hormonal suspects	16
Noncoding RNA as potential therapeutics to rescue mitochondrial dysfunction in cardiovascular diseases	16
Computational model captures cardiac growth in hypertensive pregnancies and in the postpartum period	16
Remote ischemic preconditioning and exercise-induced cardioprotection via extracellular vesicle-delivered microRNAs	15
Tobacco and electronic cigarette use with hypertension and the mediating effect of dyslipidemia – the NHANES study	15
Renal TLR-7/TNF-α pathway as a potential female-specific mechanism in the pathogenesis of autoimmune-induced hypertension	15
Recent advances associated with cardiometabolic remodeling in diabetes-induced heart failure	15
Modeling Sex-Dependent Cardiovascular Responses to Lower Body Negative Pressure	15
Late-gestation mineralocorticoid receptor antagonism lowers maternal blood pressure and attenuates placental insufficiency induced by leptin in pregnant mice	15
Exaggerated exercise pressor reflex in uncomplicated type 1 diabetes and its association with oxidative stress	15
Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity	15
Methodological approaches and the clinical utility of noninvasive estimated pulse wave velocity	15
Plasma levels of sTREM2 in chronic heart failure: predictors and prognostic relevance	15
Functional capacity and skeletal muscle morphology are linked to N-terminal proBNP but not left ventricular ejection fraction in patients with heart failure	15
Eplerenone lowers maternal blood pressure in a model of leptin-induced preeclampsia, but decreases fetal growth when administered mid-, but not late-, gestation	15
Ischemia-reperfusion myocardial infarction induces remodeling of left cardiac-projecting stellate ganglia neurons	15
Multiomics approaches to cardiovascular disease: technological innovations and clinical translation	15
Autonomic cardiovascular control during exercise	15
Loss of SIRT2 in Cardiomyocytes Reduces Glycolytic Flux via Increased Acetylation of Glycolytic Enzymes	15
The 24-h activity cycle and cardiovascular outcomes: establishing biological plausibility using arterial stiffness as an intermediate outcome	14
Regional transcriptomic profiling reveals immune system enrichment in nonfailing atria and all chambers of the failing human heart	14
Acute vascular function responses predict chronic vascular function changes to heating and exercise interventions in young, healthy recreationally active adults	14
Mlc2v-Cre induces germline recombination in a sex-biased manner	14
Hypoxic neutrophils enflame the infarcted heart	14
Heart Rate and Vascular Responses to Spontaneous Arousals Following Experimental Sleep Restriction	14
Multicomponent intervention improves gut microbiome and cardiac autonomic function in childhood obesity	14
The gut microbiome as a modulator of arterial function and age-related arterial dysfunction	14
Comprehensive ultrasound imaging of right ventricular remodeling under surgically induced pressure overload in mice	14
Sleep efficiency and PTSD symptom severity predict microvascular endothelial function and arterial stiffness in young, trauma-exposed women	14
Digital thermal monitoring of reactive hyperemia: potential mechanisms and clinical relevance among patients with heart failure with reduced ejection fraction	14
Editorial Board	14
Novel insights into the pathobiology of pulmonary hypertension in heart failure with preserved ejection fraction	14
Hypertension is linked to enhanced lymphatic contractile response via RGS16/RhoA/ROCK pathway	14
Editorial Board	14
Serial blood volume measurements in patients with compensated chronic heart failure: How do volume profiles change over time?	14
Tailoring transfection for cardiomyocyte cell lines: balancing efficiency and toxicity in lipid versus polymer-based transfection methods in H9c2 and HL-1 cells	14
Improving the inclusion of transgender and nonbinary individuals in the planning, completion, and mobilization of cardiovascular research	14
Electronic smoke, electrical storms? Cardiac arrhythmia risk in the vaping era	14
Red blood cells from patients with ST-elevation myocardial infarction and elevated C-reactive protein levels induce endothelial dysfunction	14
Characterizing the influence of cardiorespiratory fitness on left atrial size and function in the general population	13

Semaglutide augments vascular proliferation and cardiac performance in a large animal model of ischemic cardiomyopathy	13
Chemerin knockout reveals sex difference in the role of chemerin in blood pressure and vascular remodeling	13
Elevated sympathetic-mediated vasoconstriction at rest but intact functional sympatholysis during exercise in heart failure with reduced ejection fraction	13
Acute binge alcohol increases risk of arrhythmias and myocardial fibrosis in a mouse model of arrhythmogenic cardiomyopathy	13
β-Blockers are associated with increased B-type natriuretic peptide levels differently in men and women in heart failure with preserved ejection fraction	13
Oxygen uptake kinetics and chronotropic responses to exercise are impaired in survivors of severe COVID-19	13
ERBB4 activation prevents microvascular dysfunction in a large animal model of hypertensive heart disease	13
Corrigendum for Robinson et al., volume 319, 2020, p. H306–H319	13
Contextualization of observed racial differences in biomarkers to avoid racial essentialism	13
Primed for metabolic syndrome: evidence of cardiac mitochondrial dysfunction preceding disease	13
The role of T cells in vascular aging, hypertension, and atherosclerosis	13
Racial disparity in microvascular function among women with newly diagnosed breast cancer	13
Is HFpEF a chicken or an egg? Utility of models for a clinical syndrome	13
Association of right ventricular dysfunction with blood volume expansion to outcomes in chronic left-sided heart failure	13
Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model	12
Association between serum estradiol and cardiovascular health among transgender adults using gender-affirming estrogen therapy	12
Splicing factor kinase SRPK1 inhibition in monocyte: a novel therapeutic approach for peripheral arterial disease	12
Cardiac mitochondrial proteome of lean, healthy Ossabaw minipigs with predisposition to metabolic syndrome versus that of Göttingen minipigs	12
Persisting elevation of total hemoglobin mass after altitude training in elite swimmers: a potential role of prolonged erythrocyte survival	12
The stronger sex, until menopause: understanding the impact of estrogen loss on heart function	12
The neurovascular unit in type 2 diabetes: a tale of two sexes	12
Correction for Wardhana et al., volume 329, 2025, p. H1212–H1228	12
Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction	12
MRI assessed cardiac structure and function in young adult offspring of hypertensive pregnancies: a 27-year prospective follow-up birth cohort	12
Cardiomyocyte-specific LARP6 overexpression prevents angiotensin II-induced myocardial dysfunction and interstitial fibrosis	12
High-salt diet augments systolic blood pressure and induces arterial dysfunction in outbred, genetically diverse mice	12
Don't go vaping my heart: e-cigarette exposure during pregnancy promotes peripartum ventricular arrhythmias and sympathetic dominance	12
Mechanistic insight into the role of cardiac-enriched microRNAs in diabetic heart injury	12
Sex-dependent differences in bioenergetics of young mouse brain microvasculature: implications for oxygen-glucose deprivation and reoxygenation injury	12
Enhanced vascular contraction induced by exposure to angiotensin II mediated by endothelin-1 biosynthesis following PKCβ activation	12
Dual effects of the small-conductance Ca 2+ -activated K + current on human atrial electrophysiolo	12
Age-related changes in left ventricular vortex and energy loss patterns: from newborns to adults	11
What frozen human hearts can tell us about treating heart failure	11
Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice	11
Reply to Liu et al.	11
Pulsatile load during exercise: a missing piece in the functional assessment of idiopathic pulmonary arterial hypertension	11
Excitation-contraction coupling, cardiomyocyte electrophysiology, and transcriptome profiles in two HFpEF murine models: etiology and sex-dependent differences	11
Inflammation-autonomic cross talk contributes to left ventricular diastolic dysfunction in type 2 diabetes: a rationale for neuromodulation	11
Understanding Takotsubo syndrome: first evaluate your mouse model	11
Lower hemoglobin levels associate with higher baroreflex sensitivity and heart rate variability	11
The importance of biological sex in cardiac cachexia	11
Loss of Elmsan1 in cardiomyocytes leads to age-dependent cardiac dysfunction and reduced lifespan	11
Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress	11
Cardiovascular disease, perceived stress, and physical activity: population-level associations relevant to cardiovascular physiology	11
Deletion of the Aryl Hydrocarbon Receptor in Endothelial Cells Improves Ischemic Angiogenesis in Chronic Kidney Disease	11
Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension	11
High variability in the reproducibility of key hemodynamic responses to head-up tilt	11
A minimally invasive swine model of chronic kidney disease-associated heart failure	11
Interleukin 4/13 signaling in cardiac regeneration and repair	11
Cerebral arteries in mice with sickle cell disease are exposed to larger areas of low wall shear stress	11
Collagen VIII: a new guardian of endothelial cell identity in atherosclerosis	10
Carotid dysfunction in senescent female mice is mediated by increased α1A‐adrenoceptor activity and COX-derived vasoconstrictor prostanoids	10
Cardiac myosin motor deficits are associated with left ventricular dysfunction in human ischemic heart failure	10
Activation of the nonneuronal cholinergic cardiac system by hypoxic preconditioning protects isolated adult cardiomyocytes from hypoxia/reoxygenation injury	10
New cardiac targets for empagliflozin: O-GlcNAcylation, CaMKII, and calcium handling	10
PDE-5 inhibition mitigates mental stress-induced endothelial dysfunction in resistant hypertension	10
Development and characterization of a mass cytometry panel for detecting the effect of acute doxorubicin exposure on murine cardiac nonmyocytes	10
Linking maternal and neonatal circulation in preeclampsia	10
Obesity blunts amelioration of cardiac hypertrophy and fibrosis by human mesenchymal stem/stromal cell-derived extracellular vesicles	10
Examining oxidative stress as a mechanistic link between sleep irregularity and cardiovascular risk in young adults with chronic anxiety	10
Developmental nicotine exposure alters cardiovascular structure and function in neonatal and juvenile rats	10
Cardiac redox imbalance upon disruption of selenocysteine decomposition in mice	10
Pregnancy-dependent cardioprotection via GPER activation in Dahl salt-sensitive rats with superimposed preeclampsia	10
Evolving hemodynamics in Fontan circulation: age-driven insights in patients with interrupted inferior vena cava and hepatoazygos shunt	10
Gender-affirming estrogen therapy route of administration and cardiovascular risk: a systematic review and narrative synthesis	10
Chloride/bicarbonate exchange adversely modifies cardiovascular responses to traumatic brain injury	10
Disrupting the Heart–Brain Axis: The Combined Impact of Parental Obesity and Alzheimer Disease	10
Effect of insulin on indices of cerebral blood flow and cerebrovascular compliance in young adults	10
Left ventricular flow dynamics in preterm infants assessed with high frame rate echocardiography with blood speckle tracking	10
The FXYD1 protein plays a protective role against pulmonary hypertension and arterial remodeling via redox and inflammatory mechanisms	10
Guidelines for evaluating endothelial function in vascular tissue	10
Intracoronary ECG ST-segment shift remission time during reactive myocardial hyperemia: a new method to assess hemodynamic coronary stenosis severity	10
Inhibition of kinin B1 receptor alleviates SARS-CoV-2-induced long-lasting cardiovascular complications	10
Ischemic damage to every segment of the oxidative phosphorylation cascade elevates ETC driving force and ROS production in cardiac mitochondria	10
Retraction for Howard et al., volume 301, 2011, H1447–H1455	10
Is there an “athlete’s vein”?	10
Differential effects of myosin activators on myocardial contractile function in nonfailing and failing human hearts	10
Extracellular vesicles in preeclampsia: drivers of vascular dysfunction and inflammation	10
Selective elevation in external carotid artery flow during acute gravitational transition to microgravity during parabolic flight	9
Considering impact of age and sex on cardiac cytoskeletal components	9
Modeling HFpEF in mice: role of lifestyle interventions and implications for humans with heart failure	9
Heart and health behavior responses to GLP-1 receptor agonists: a 12-wk study using wearable technology and causal inference	9
Glucocorticoids impair T lymphopoiesis after myocardial infarction	9
Bend it like BIN1: how a membrane-curving adaptor protein shapes cardiac physiology	9
Clinical significance and correlation of microRNA-21 expression in patients undergoing transcatheter aortic valve replacement	9
Decreased ability to manage increases in reactive oxygen species may underlie susceptibility to arrhythmias in mice lacking Scn1b	9
TREK-1: a Janus-faced and subcellular location-based regulator of cardiac remodeling in heart failure	9
Rethinking aortic stenosis quantification: from linear assumptions to sigmoid reality—critical considerations for clinical translation	9
Effects of dietary soy content on cerebral artery function and behavior in ovariectomized female mice	9
Persistence of cardiac malprogramming in late gestational fetal sheep by early to midgestational testosterone excess	9
Heartbreak to immune breakdown: myocardial infarction is causing thymic injury mediated by activation of the hypothalamus-pituitary-adrenal axis	9
Loss of ADAM15 in female mice does not worsen pressure overload cardiomyopathy, independent of ovarian hormones	9
Microvascular dysfunction and neurovascular uncoupling are exacerbated in peripheral artery disease, increasing the risk of cognitive decline in older adults	9
Cardiac energy substrate utilization in heart failure with preserved ejection fraction: reconciling conflicting evidence on fatty acid and glucose metabolism	9
Bioactive factors in Endometriosis Peritoneal Fluid Remodel Human Cardiomyocytes	9