American Journal of Physiology-Heart and Circulatory Physiology

Article	Citations
Expanding the supply of donor hearts through donation after circulatory death	97
Temporal effects of sympathetic denervation on aortic remodeling and rupture in experimental abdominal aortic aneurysm	77
Editorial Board	71
Volume responsiveness revisited: an observational multicenter study of continuous versus binary outcomes combining echocardiography and venous return physiology	68
Implications of Sm22α-Cre expression in keratinocytes and unanticipated inflammatory skin lesion in a model of atherosclerosis	66
Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure	61
Adverse pregnancy outcomes and renal-vascular function in the early years after delivery	60
An in silico approach to understanding the interaction between cardiovascular and pulmonary lymphatic dysfunction	60
Prenatal stress induces sex- and tissue-specific alterations in insulin pathway of Wistar rats offspring	53
Sex differences in the peripheral determinants of oxygen transport and utilization in patients with heart failure with preserved ejection fraction	49
The multifaceted roles of red blood cells in health and disease	48
Mannitol and hyponatremia regulate cardiac ventricular conduction in the context of sodium channel loss of function	45
An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency	45
Innervation of adipocytes is limited in mouse perivascular adipose tissue	44
Genetic deletion of cytoglobin exacerbates cardiac hypertrophy and inhibits cardiac fibroblast activation independent of changes in blood pressure	43
Sex differences in cardiovascular disease and dysregulation in Down syndrome	43
Parental obesity exacerbates cognitive dysfunction and cardiac vulnerability in offspring of an Alzheimer disease model	40
Muscle metaboreflex dysfunction in cardiovascular disease	39
The meaning of volume responsiveness and its relationship to venous return	38
Anthracycline cardiotoxicity is exacerbated by global p38β genetic ablation in a sexually dimorphic manner but unaltered by cardiomyocyte-specific p38α loss	38
Modifying the electrical excitability of cardiomyocytes in rainbow trout ( Oncorhynchus mykiss ) through exercise training	37
Immune interactions in pembrolizumab (PD-1 inhibitor) cancer therapy and cardiovascular complications	37
lncRNAs in vascular senescence and microvascular remodeling	36
The vulnerable preterm heart: tale from the two chambers	35
Parental obesity predisposes male and female offspring to exacerbated cardiac dysfunction and increased mortality after myocardial infarction	34

Farther and faster: enhancing skeletal muscle performance	34
Stem cell-derived heterocellular atrial engineered cardiac tissue with comparisons to native human atrial myocardium	34
Guidelines for assessing ventricular pressure-volume relationships in rodents	33
Sclerostin ablation prevents aortic valve stenosis in mice	32
Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum	32
RORα- Adra1a : Defining a New Transcriptional Axis in Cardiomyocyte Biology	32
Sleeping on oxidative stress as a mechanism underlying cardiovascular risk in chronic anxiety	30
Closing the window on COVID-19 case-control studies	30
Reflex sympathetic activation to inspiratory muscle loading is attenuated in females relative to males	29
Guidelines for in vivo models of developmental programming of cardiovascular disease risk	29
Reply to Skalidis et al.	29
Inflammation in a severe model of dystrophic cardiomyopathy contains a high proportion of T cells that contribute to onset of pathology	29
Exercise as a Vital Sign in Cardiopulmonary Disease: Insights from Wave Intensity Analysis	29
Arterial stiffness preceding metabolic syndrome in 3,862 adolescents: a mediation and temporal causal longitudinal birth cohort study	28
Tissue inhibitor of metalloproteinase-4 deletion in mice impacts maternal cardiac function during pregnancy and postpartum	28
Relative contributions of mitochondrial and nonmitochondrial oxidative stress in age-related cutaneous microvascular endothelial dysfunction	28
Fetal cardiac troponin I levels decline toward birth in sheep	28
Interaction of macro- and microvascular function underlies brachial artery flow-mediated dilation in humans	28
Sexual dimorphism of psychological stress-induced susceptibility to ischemic heart disease: Is the king naked?	27
Assessment of impact of low-flow state on long-term outcome in multiethnic population using cardiac magnetic resonance	27
Correction for Ranjan et al., volume 328, 2025, p. H447–H459	27
Cardiomyocyte-specific disruption of soluble epoxide hydrolase limits inflammation to preserve cardiac function	26
Constipation as a new nontraditional significant contributor to cardiovascular disease	26
Corrigendum for Bigler et al., volume 327, 2024, p. H1124–H1131	26
Modes of onset of ventricular arrhythmias in J-wave syndromes: mechanistic insights from computational modeling	25
Corrigendum for Methawasin et al., volume 328, 2025, p. H719–H733	25
A perinatal approach for unraveling mitochondrial function in preeclampsia and fetal growth restriction: a role for mitochondrial-targeted therapies	24
Beyond Cancer: Breast Cancer Gene 2 Emerges as a New Player in Atherosclerosis	24
COP9 signalosome deneddylation activity is required for proliferation but not dedifferentiation of vascular smooth muscle cells in neointimal hyperplasia	24
Electronic hookah (waterpipe) vaping reduces vascular endothelial function: the role of nicotine	24
Cardiac stasis imaging, stroke, and silent brain infarcts in patients with nonischemic dilated cardiomyopathy	24
Microcirculatory perfusion pulsatility in foot sole skin is a marker of treatment response in chronic limb-threatening ischemia	24
Insights into the associations between the gut microbiome, its metabolites, and heart failure	24
Is a decline in myocardial citrullination in the aged female heart really PAD2 the bone?	23
Mechanisms matter: a powerful example of insights gained through computational physiology	23
X’s, Y’s, and vascular ties: exploring the role of sex chromosomes in arterial stiffness and vascular aging	23
Role of membrane microdomains in cardiac protection: strategies for diabetic cardiomyopathy	23
Chronotype and metabolic syndrome in midlife: findings from the Northern Finland Birth Cohort 1966	23
Connecting the dots between FXR1 isoforms and miR-1 in pediatric dilated cardiomyopathy	23
Cardiac health, type I collagen, and aging in the oim/oim mouse model of osteogenesis imperfecta and a cohort of adults with OI	23
Coronary artery endothelial function and aging in people with HIV and HIV-negative individuals	22
Bedding as a variable affecting fasting blood glucose and vascular physiology in mice	22
When it comes to the heart, age, and sex matter (sometimes)	22
Vascular insulin resistance as a potential mechanism of increased cardiovascular risk in gestational diabetes	22
To err, KIR2 that is, on the side of vasodilation in aging	22
Multiomic and electrophysiologic analyses reveal that an inherited MRC2 variant causes fibroblast dysfunction and increased atrial fibrillation susceptibility	21
Deep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity in RBM20 cardiomyopathy	21
Sex differences in the functional morphology of coronary arteries in embryonic mice	21
Contributions of cardiac output and total peripheral resistance to interindividual variability in peak exercise blood pressure in young adults	21
Accelerating systematic reviews: a novel 1-wk screening protocol using rule-based automation with AI-assisted Python coding	21

Sex as a biological variable in exercise prescription: a critical consideration in developing a road map for sex-related differences in cardiovascular research	20
Echocardiographic imaging in conscious, unsedated sheep: a novel approach enabling apical views for advanced cardiac assessment	20
Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia	20
Are supine assessments an ecologically valid method to characterize sitting-induced declines in lower-limb vascular health?	20
Novel role of vascular chemerin in blood vessel tone	20
Beyond TAPSE: clinical and methodological perspectives on 3D-derived right ventricular	20
Sex-specific responses to slow progressive pressure overload in a large animal model of HFpEF	20
Sugar-coating the endothelium: adaptive or maladaptive?	20
Increased adiposity impairs vascular function in postmenopausal women in hemodialysis	20
Corrigendum for Ferreira et al., volume 325, 2023, p. H774–H789	19
Milieu-dependent small-cavity diabetic HFpEF in the DIO-STZ model	19
Influence of exercise training on the left atrium: implications for atrial fibrillation, heart failure, and stroke	19
Salsalate negatively impacts microvascular function in women with endometriosis	19
Rostafuroxin ameliorates cardiac glycoside-induced cardiomyocyte electrolyte imbalances and arrhythmia in ovo	19
Who was the catalyst for the doubling of NIH funding in the late 1990s? Maybe we should thank Senator Tom Daschle	19
Statin therapy improves locomotor muscle microvascular reactivity in patients with heart failure with preserved ejection fraction	18
Detecting rapid elevations in blood pressure using a novel pulse arrival time and machine learning technique	18
Structural and functional adaptations of human cardiomyocytes in metabolic disease and heart failure	18
Single-cell ionic current phenotyping explains stem cell-derived cardiomyocyte action potential morphology	18
Aortic aneurysm and dissection: complement and precision medicine in aortic disease	18
Differential right ventricular afterload during exercise in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension	18
Sublingual microcirculatory function as a prognostic indicator of general microvascular health	18
Whole genome transcriptomics reveal distinct atrial versus ventricular responses to neonatal hyperoxia	18
Serial and regional assessment of the right ventricular molecular and functional response to pressure loading	17
Programming the heart: prenatal glucocorticoids and sex-specific cardiovascular risk	17
Advanced phenotyping in patients with a Fontan circulation uncovers effects of pulmonary vascular disease	17
Procurement and preservation of neonatal porcine cardiac tissue	17
Late-gestation mineralocorticoid receptor antagonism lowers maternal blood pressure and attenuates placental insufficiency induced by leptin in pregnant mice	17
Eplerenone lowers maternal blood pressure in a model of leptin-induced preeclampsia, but decreases fetal growth when administered mid-, but not late-, gestation	17
Bone morphogenetic protein 10: clinical correlates and risk of incident atrial fibrillation	17
Predictive value of triglyceride-glucose index for the evaluation of coronary artery disease severity and occurrence of major adverse cardiovascular events	17
The role of α 2 -adrenergic mechanisms in sympathetic baroreflex control of human blood pressure	17
Acceleration of age-related impairments in vascular function in women: interrogation of the (un)usual hormonal suspects	17
Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity	17
Gestational diabetes promotes future maternal cardiovascular disease through endothelin activation and suppressed NO/cGMP/PRKG and AMPK/SIRT1 signaling pathways	17
Sex differences in aortic valve inflammation and remodeling in chronic severe aortic regurgitation	17
Temporal mineralocorticoid receptor activation regulates the molecular clock and transcription of cardiovascular disease modulators in myeloid cells	17
Beyond the QT interval: how QT/RR hysteresis may reveal a sex-dependent hidden risk for cardiac arrhythmias	17
Ebbs and tides of endothelial K+ currents that regulate blood flow	17
Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection	17
Noncoding RNA as potential therapeutics to rescue mitochondrial dysfunction in cardiovascular diseases	17
Early- to mid-gestational testosterone excess leads to adverse cardiac outcomes in postpartum sheep	16
Female mice are protected from impaired parenchymal arteriolar TRPV4 function and impaired cognition in hypertension	16
Remote ischemic preconditioning and exercise-induced cardioprotection via extracellular vesicle-delivered microRNAs	16
Mechanical response of cardiac microtissues to acute localized injury	16
Real-time visualization of dextran extravasation in intermittent hypoxia mice using noninvasive SWIR imaging	16
Exaggerated exercise pressor reflex in uncomplicated type 1 diabetes and its association with oxidative stress	16
Impact of ovary-intact menopause in a mouse model of heart failure with preserved ejection fraction	16
Modeling sex-dependent cardiovascular responses to lower body negative pressure	16
Methodological approaches and the clinical utility of noninvasive estimated pulse wave velocity	16
Renal TLR-7/TNF-α pathway as a potential female-specific mechanism in the pathogenesis of autoimmune-induced hypertension	16
Autonomic cardiovascular control during exercise	16
Neutralization of reactive oxygen species with cobinamide augments aortic dissections and rupture in BAPN-administered mice	15
Ventricular-arterial coupling and cardiovascular risk among young adults: The African-PREDICT study	15
Multiomics approaches to cardiovascular disease: technological innovations and clinical translation	15
Cardiovascular and aortic wave reflection responses to evening binge alcohol consumption	15
Recent advances associated with cardiometabolic remodeling in diabetes-induced heart failure	15
Ischemia-reperfusion myocardial infarction induces remodeling of left cardiac-projecting stellate ganglia neurons	15
Skin pigmentation is negatively associated with circulating vitamin D concentration and cutaneous microvascular endothelial function	15
Role of adropin in arterial stiffening associated with obesity and type 2 diabetes	15
Computational model captures cardiac growth in hypertensive pregnancies and in the postpartum period	15
Loss of SIRT2 in cardiomyocytes reduces glycolytic flux via increased acetylation of glycolytic enzymes	15
Tobacco and electronic cigarette use with hypertension and the mediating effect of dyslipidemia – the NHANES study	15
Regional transcriptomic profiling reveals immune system enrichment in nonfailing atria and all chambers of the failing human heart	14
Mlc2v-Cre induces germline recombination in a sex-biased manner	14
Hypoxic neutrophils enflame the infarcted heart	14
Tailoring transfection for cardiomyocyte cell lines: balancing efficiency and toxicity in lipid versus polymer-based transfection methods in H9c2 and HL-1 cells	14
Multicomponent intervention improves gut microbiome and cardiac autonomic function in childhood obesity	14
Primed for metabolic syndrome: evidence of cardiac mitochondrial dysfunction preceding disease	14
Red blood cells from patients with ST-elevation myocardial infarction and elevated C-reactive protein levels induce endothelial dysfunction	14
Plasma levels of sTREM2 in chronic heart failure: predictors and prognostic relevance	14
Characterizing the influence of cardiorespiratory fitness on left atrial size and function in the general population	14
Functional capacity and skeletal muscle morphology are linked to N-terminal proBNP but not left ventricular ejection fraction in patients with heart failure	14
Electronic smoke, electrical storms? Cardiac arrhythmia risk in the vaping era	14
Acute vascular function responses predict chronic vascular function changes to heating and exercise interventions in young, healthy recreationally active adults	14
Semaglutide augments vascular proliferation and cardiac performance in a large animal model of ischemic cardiomyopathy	14
Novel insights into the pathobiology of pulmonary hypertension in heart failure with preserved ejection fraction	14
Digital thermal monitoring of reactive hyperemia: potential mechanisms and clinical relevance among patients with heart failure with reduced ejection fraction	14
Serial blood volume measurements in patients with compensated chronic heart failure: How do volume profiles change over time?	14
Editorial Board	14

Comprehensive ultrasound imaging of right ventricular remodeling under surgically induced pressure overload in mice	14
β-Blockers are associated with increased B-type natriuretic peptide levels differently in men and women in heart failure with preserved ejection fraction	14
Heart rate and vascular responses to spontaneous arousals following experimental sleep restriction	14
Editorial Board	14
Combined androgen excess polycystic ovary syndrome and obesity are associated with elevated beat-to-beat blood pressure variability in adult women	13
ERBB4 activation prevents microvascular dysfunction in a large animal model of hypertensive heart disease	13
The nuclear receptor ROR-alpha is a putative novel myogenic regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor	13
Oxygen uptake kinetics and chronotropic responses to exercise are impaired in survivors of severe COVID-19	13
Contextualization of observed racial differences in biomarkers to avoid racial essentialism	13
Improving the inclusion of transgender and nonbinary individuals in the planning, completion, and mobilization of cardiovascular research	13
Acute binge alcohol increases risk of arrhythmias and myocardial fibrosis in a mouse model of arrhythmogenic cardiomyopathy	13
Hypertension is linked to enhanced lymphatic contractile response via RGS16/RhoA/ROCK pathway	13
Elevated sympathetic-mediated vasoconstriction at rest but intact functional sympatholysis during exercise in heart failure with reduced ejection fraction	13
Sleep efficiency and PTSD symptom severity predict microvascular endothelial function and arterial stiffness in young, trauma-exposed women	13
The gut microbiome as a modulator of arterial function and age-related arterial dysfunction	13
The role of T cells in vascular aging, hypertension, and atherosclerosis	13
Chemerin knockout reveals sex difference in the role of chemerin in blood pressure and vascular remodeling	13
The 24-h activity cycle and cardiovascular outcomes: establishing biological plausibility using arterial stiffness as an intermediate outcome	13
Racial disparity in microvascular function among women with newly diagnosed breast cancer	13
Cerebral arteries in mice with sickle cell disease are exposed to larger areas of low wall shear stress	12
Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress	12
Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model	12
Dual effects of the small-conductance Ca 2+ -activated K + current on human atrial electrophysiolo	12
Left ventricular chamber stiffness and strain determines the myocardial transcriptional response to elevated filling pressure	12
High-salt diet augments systolic blood pressure and induces arterial dysfunction in outbred, genetically diverse mice	12
Cardiac mitochondrial proteome of lean, healthy Ossabaw minipigs with predisposition to metabolic syndrome versus that of Göttingen minipigs	12
Mechanistic insight into the role of cardiac-enriched microRNAs in diabetic heart injury	12
Excitation-contraction coupling, cardiomyocyte electrophysiology, and transcriptome profiles in two HFpEF murine models: etiology and sex-dependent differences	12
Inflammation-autonomic cross talk contributes to left ventricular diastolic dysfunction in type 2 diabetes: a rationale for neuromodulation	12
Sex-dependent differences in bioenergetics of young mouse brain microvasculature: implications for oxygen-glucose deprivation and reoxygenation injury	12
Corrigendum for Robinson et al., volume 319, 2020, p. H306–H319	12
Correction for Wardhana et al., volume 329, 2025, p. H1212–H1228	12
Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction	12
Cardiovascular disease, perceived stress, and physical activity: population-level associations relevant to cardiovascular physiology	12
Don't go vaping my heart: e-cigarette exposure during pregnancy promotes peripartum ventricular arrhythmias and sympathetic dominance	11
Association between serum estradiol and cardiovascular health among transgender adults using gender-affirming estrogen therapy	11
Developmental nicotine exposure alters cardiovascular structure and function in neonatal and juvenile rats	11
Carotid dysfunction in senescent female mice is mediated by increased α1A‐adrenoceptor activity and COX-derived vasoconstrictor prostanoids	11
Reply to Liu et al.	11
Pulsatile load during exercise: a missing piece in the functional assessment of idiopathic pulmonary arterial hypertension	11
The neurovascular unit in type 2 diabetes: a tale of two sexes	11
Clinical utility of single ventricular stroke work index for predicting prognosis in patients with functional single ventricle	11
Persisting elevation of total hemoglobin mass after altitude training in elite swimmers: a potential role of prolonged erythrocyte survival	11
YBX1 as a developmental regulator of ventricular morphogenesis and a potential target in cardiac pathology	11
Understanding Takotsubo syndrome: first evaluate your mouse model	11
Intracoronary ECG ST-segment shift remission time during reactive myocardial hyperemia: a new method to assess hemodynamic coronary stenosis severity	11
Activation of the nonneuronal cholinergic cardiac system by hypoxic preconditioning protects isolated adult cardiomyocytes from hypoxia/reoxygenation injury	11
The importance of biological sex in cardiac cachexia	11
Is HFpEF a chicken or an egg? Utility of models for a clinical syndrome	11
Splicing factor kinase SRPK1 inhibition in monocyte: a novel therapeutic approach for peripheral arterial disease	11
Age-related changes in left ventricular vortex and energy loss patterns: from newborns to adults	11
Cardiomyocyte-specific LARP6 overexpression prevents angiotensin II-induced myocardial dysfunction and interstitial fibrosis	11
MRI assessed cardiac structure and function in young adult offspring of hypertensive pregnancies: a 27-year prospective follow-up birth cohort	11
Association of right ventricular dysfunction with blood volume expansion to outcomes in chronic left-sided heart failure	11
Cardiac myosin motor deficits are associated with left ventricular dysfunction in human ischemic heart failure	11
Lower hemoglobin levels associate with higher baroreflex sensitivity and heart rate variability	11
Deletion of the Aryl Hydrocarbon Receptor in Endothelial Cells Improves Ischemic Angiogenesis in Chronic Kidney Disease	11
Enhanced vascular contraction induced by exposure to angiotensin II mediated by endothelin-1 biosynthesis following PKCβ activation	11
Interleukin 4/13 signaling in cardiac regeneration and repair	11
Reply to Miyabe and Miyabe	11
Collagen VIII: a new guardian of endothelial cell identity in atherosclerosis	10
What frozen human hearts can tell us about treating heart failure	10
Pregnancy-dependent cardioprotection via GPER activation in Dahl salt-sensitive rats with superimposed preeclampsia	10
Bridging the gap: connexin 43 at the frontline of endothelial repair	10
The cardiomyocyte origins of diastolic dysfunction: cellular components of myocardial “stiffness”	10
Cigarette exposure lights the NLPR3 inflammasome pathway to atrial fibrillation	10
High variability in the reproducibility of key hemodynamic responses to head-up tilt	10
Association between blood pressure and invasive hemodynamic measures in myocardial bridging	10
Evolving hemodynamics in Fontan circulation: age-driven insights in patients with interrupted inferior vena cava and hepatoazygos shunt	10
Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension	10
The FXYD1 protein plays a protective role against pulmonary hypertension and arterial remodeling via redox and inflammatory mechanisms	10
Obesity blunts amelioration of cardiac hypertrophy and fibrosis by human mesenchymal stem/stromal cell-derived extracellular vesicles	10
Guidelines for evaluating endothelial function in vascular tissue	10
Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice	10
Glucocorticoids impair T lymphopoiesis after myocardial infarction	10
Hippo signaling pathway and mitochondrial dysfunction in Takotsubo syndrome	10
Sex differences and role of lysyl oxidase-like 2 in angiotensin II-induced hypertension in mice	10
Inhibition of kinin B1 receptor alleviates SARS-CoV-2-induced long-lasting cardiovascular complications	10
Effect of insulin on indices of cerebral blood flow and cerebrovascular compliance in young adults	10
Cardiac redox imbalance upon disruption of selenocysteine decomposition in mice	10
Autonomic nervous system influences on beat-to-beat blood pressure variability in healthy young adults	10
Extracellular vesicles in preeclampsia: drivers of vascular dysfunction and inflammation	10
Linking maternal and neonatal circulation in preeclampsia	10
Examining oxidative stress as a mechanistic link between sleep irregularity and cardiovascular risk in young adults with chronic anxiety	10
Left ventricular flow dynamics in preterm infants assessed with high frame rate echocardiography with blood speckle tracking	10
Loss of Elmsan1 in cardiomyocytes leads to age-dependent cardiac dysfunction and reduced lifespan	10
Acute arrhythmias in a long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency mouse model	10
Reply to Madias	10
PDE-5 inhibition mitigates mental stress-induced endothelial dysfunction in resistant hypertension	10
Differential effects of myosin activators on myocardial contractile function in nonfailing and failing human hearts	10
A minimally invasive swine model of chronic kidney disease-associated heart failure	10
Ischemic damage to every segment of the oxidative phosphorylation cascade elevates ETC driving force and ROS production in cardiac mitochondria	10
Gender-affirming estrogen therapy route of administration and cardiovascular risk: a systematic review and narrative synthesis	10
Disrupting the heart-brain axis: the combined impact of parental obesity and Alzheimer disease	10
New cardiac targets for empagliflozin: O-GlcNAcylation, CaMKII, and calcium handling	10